The YAP/TAZ family of transcriptional co‐activators drives cell proliferation in epithelial tissues and cancers. Yet, how YAP and TAZ are physiologically regulated remains unclear. Here we review recent reports that YAP and TAZ act primarily as sensors of epithelial cell polarity, being inhibited when cells differentiate an apical membrane domain, and being activated when cells contact the extracellular matrix via their basal membrane domain. Apical signalling occurs via the canonical Crumbs/CRB‐Hippo/MST‐Warts/LATS kinase cascade to phosphorylate and inhibit YAP/TAZ. Basal signalling occurs (...) via Integrins and Src family kinases to phosphorylate and activate YAP/TAZ. Thus, YAP/TAZ is localised to the nucleus in basal stem/progenitor cells and cytoplasm in differentiated squamous cells or columnar cells. In addition, other signals such as mechanical forces, tissue damage and possibly receptor tyrosine kinases (RTKs) can influence MST‐LATS or Src family kinase activity to modulate YAP/TAZ activity. (shrink)

Most philosophers agree that causal knowledge is essential to decision-making: agents should choose from the available options those that probably cause the outcomes that they want. This book argues against this theory and in favour of evidential or Bayesian decision theory, which emphasises the symptomatic value of options over their causal role. It examines a variety of settings, including economic theory, quantum mechanics and philosophical thought-experiments, where causal knowledge seems to make a practical difference. The arguments make novel use of (...) machinery from other areas of philosophical inquiry, including first-person epistemology and the free will debate. The book also illustrates the applicability of decision theory itself to questions about the direction of time and the special epistemic status of agents. (shrink)

Feminism is sensational -- On being directed -- Willfulness and feminist subjectivity -- Trying to transform -- Being in question -- Brick walls -- Fragile connections -- Feminist snap -- Lesbian feminism -- Conclusion 1: A killjoy survival kit -- Conclusion 2: A killjoy manifesto.

Introduction: find your way -- Orientations toward objects -- Sexual orientation -- The orient and other others -- Conclusion: disorientation and queer objects.

In What's the Use? Sara Ahmed continues the work she began in The Promise of Happiness and Willful Subjects by taking up a single word--in this case, use--and following it around. She shows how use became associated with life and strength in nineteenth century biological and social thought and considers how utilitarianism offered a set of educational techniques for shaping individuals by directing them toward useful ends. Ahmed also explores how spaces become restricted to some uses and users (...) with specific reference to universities. She notes, however, the potential for queer use: how things can be used in ways that were not intended or by those for whom they were not intended. Ahmed posits queer use as way of reanimating the project of diversity work as the ordinary and painstaking work of opening up institutions to those who have historically been excluded from them. (shrink)

Differences That Matter challenges existing ways of theorising the relationship between feminism and postmodernism which ask 'is or should feminism be modern or postmodern?' Sara Ahmed suggests that postmodernism has been allowed to dictate feminist debates and calls instead for feminist theorists to speak (back) to postmodernism, rather than simply speak on (their relationship to) it. Such a 'speaking back' involves a refusal to position postmodernism as a generalisable condition of the world and requires closer readings of what postmodernism (...) is actually 'doing' in a variety of disciplinary contexts. Sara Ahmed hence examines constructions of postmodernism in relation to rights, ethics, subjectivity, authorship, meta-fiction and film. (shrink)

We consider countable so‐called rich subsemigroups of ; each such semigroup T gives a variety CPEAT that is axiomatizable by a finite schema of equations taken in a countable subsignature of that of ω‐dimensional cylindric‐polyadic algebras with equality where substitutions are restricted to maps in T. It is shown that for any such T, if and only if is representable as a concrete set algebra of ω‐ary relations. The operations in the signature are set‐theoretically interpreted like in polyadic equality set (...) algebras, but such operations are relativized to a union of cartesian spaces that are not necessarily disjoint. This is a form of guarding semantics. We show that CPEAT is canonical and atom‐canonical. Imposing an extra condition on T, we prove that atomic algebras in CPEAT are completely representable and that CPEAT has the super amalgamation property. If T is rich and finitely represented, it is shown that CPEAT is term definitionally equivalent to a finitely axiomatizable Sahlqvist variety. Such semigroups exist. This can be regarded as a solution to the central finitizability problem in algebraic logic for first order logic with equality if we do not insist on full fledged commutativity of quantifiers. The finite dimensional case is approached from the view point of guarded and clique guarded (relativized) semantics of fragments of first order logic using finitely many variables. Both positive and negative results are presented. (shrink)

This study investigates the association of a broad set of variables with the ethical decision making of management accountants in Libya. Adopting a cross-sectional methodology, a questionnaire including four different ethical scenarios was used to gather data from 229 participants. For each scenario, ethical decision making was examined in terms of the recognition, judgment and intention stages of Rest’s model. A significant relationship was found between ethical recognition and ethical judgment and also between ethical judgment and ethical intention, but ethical (...) recognition did not significantly predict ethical intention—thus providing support for Rest’s model. Organizational variables, age and educational level yielded few significant results. The lack of significance for codes of ethics might reflect their relative lack of development in Libya, in which case Libyan companies should pay attention to their content and how they are supported, especially in the light of the under-development of the accounting profession in Libya. Few significant results were also found for gender, but where they were found, males showed more ethical characteristics than females. This unusual result reinforces the dangers of gender stereotyping in business. Personal moral philosophy and moral intensity dimensions were generally found to be significant predictors of the three stages of ethical decision making studied. One implication of this is to give more attention to ethics in accounting education, making the connections between accounting practice and Islam. Overall, this study not only adds to the available empirical evidence on factors affecting ethical decision making, notably examining three stages of Rest’s model, but also offers rare insights into the ethical views of practising management accountants and provides a benchmark for future studies of ethical decision making in Muslim majority countries and other parts of the developing world. (shrink)

The best-known argument for Evidential Decision Theory (EDT) is the ‘Why ain’cha rich?’ challenge to rival Causal Decision Theory (CDT). The basis for this challenge is that in Newcomb-like situations, acts that conform to EDT may be known in advance to have the better return than acts that conform to CDT. Frank Arntzenius has recently proposed an ingenious counter argument, based on an example in which, he claims, it is predictable in advance that acts that conform to EDT will do (...) less well than acts that conform to CDT. We raise two objections to Arntzenius’s example. We argue, first, that the example is subtly incoherent, in a way that undermines its effectiveness against EDT; and, second, that the example relies on calculating the average return over an inappropriate population of acts. (shrink)

An interpolation Theorem is proved for first order logic with infinitary predicates. Our proof is algebraic via cylindric algebras.1.

The primary and secondary sources of Islamic law often assume a binary distinction between ijtihād and taqlīd, ignoring a third level of engagement with the sources, which was conceptualized by some jurists as forming a distinct category. In this article I discuss the evolution of the terms ijtihād, taqlīd, and ittibāʿ, using a conceptual-historical approach. I argue that the use of taqlīd to mean “precedent-following” did not emerge as a technical term until after the time of al-Shāfiʿī. The distinction between (...) precedent-following and verifiable-following did not appear in legal discourse until the time of Aḥmad b. Ḥanbal. I also demonstrate that there were three approaches to these terms in legal discourse after the time of Ibn Ḥanbal, with three groups of jurists defining them in ways that advanced their different visions of law-making. I conclude with a discussion of the debate over the meanings of these terms in the eighteenth and nineteenth centuries. (shrink)

We describe the earliest occurrences of the Liar Paradox in the Arabic tradition. e early Mutakallimūn claim the Liar Sentence is both true and false; they also associate the Liar with problems concerning plural subjects, which is somewhat puzzling. Abharī (1200-1265) ascribes an unsatisfiable truth condition to the Liar Sentence—as he puts it, its being true is the conjunction of its being true and false—and so concludes that the sentence is not true. Tūsī (1201-1274) argues that self-referential sentences, like the (...) Liar, are not truth-apt, and defends this claim by appealing to a correspondence theory of truth. Translations of the texts are provided as an appendix. (shrink)

In _Willful Subjects_ Sara Ahmed explores willfulness as a charge often made by some against others. One history of will is a history of attempts to eliminate willfulness from the will. Delving into philosophical and literary texts, Ahmed examines the relation between will and willfulness, ill will and good will, and the particular will and general will. Her reflections shed light on how will is embedded in a political and cultural landscape, how it is embodied, and how will (...) and willfulness are socially mediated. Attentive to the wayward, the wandering, and the deviant, Ahmed considers how willfulness is taken up by those who have received its charge. Grounded in feminist, queer, and antiracist politics, her sui generis analysis of the willful subject, the figure who wills wrongly or wills too much, suggests that willfulness might be required to recover from the attempt at its elimination. (shrink)

Buildings energy consumption is growing gradually and put away around 40% of total energy use. Predicting heating and cooling loads of a building in the initial phase of the design to find out optimal solutions amongst different designs is very important, as ell as in the operating phase after the building has been finished for efficient energy. In this study, an artificial neural network model was designed and developed for predicting heating and cooling loads of a building based on a (...) dataset for building energy performance. The main factors for input variables are: relative compactness, roof area, overall height, surface area, glazing are a, wall area, glazing area distribution of a building, orientation, and the output variables: heating and cooling loads of the building. The dataset used for training are the data published in the literature for various 768 residential buildings. The model was trained and validated, most important factors affecting heating load and cooling load are identified, and the accuracy for the validation was 99.60%. (shrink)

The United Nations has been holding the High-Level Political Forum (HLPF) annually since 2015, where countries meet to discuss the progress, they have made in achieving the sustainable development goals of the 2030 Vision, and to identify the challenges they face, their areas of focus in the future, and to evaluate their efforts in achieving and submitting voluntary reports on this. The research seeks to analyze Arabic translation of the speech of the Kingdom of Saudi Arabia; as a special type (...) of political communication to reveal the most prominent strategies that have formed it, and to identify the mechanisms that have been achieved; which has given the speech its uniqueness and efficacy, as each speech carries with it its strategies and mechanisms that lead to its success or failure. The study adopted the pragmatic approach imposed by the nature of this work. It came up with a set of results, the most prominent of which is that the solidarity strategy is the most effective in achieving the goals of the Kingdom’s speech, and thus this strategy was an introduction to other strategies, especially the persuasive and directive strategies. (shrink)

Drawing on social exchange theory, this study examines a mechanism, namely organizational social capital, through which self-sacrificial leadership is related to two types of employee behaviours: organizational citizenship behaviours and counterproductive behaviours. The results of two different studies in Egypt showed that self-sacrificial leadership is positively related to OSC which, in turn, is positively related to OCBs and negatively related to CPBs. Overall, the findings suggest that self-sacrificial leaders are more likely to achieve desirable employee behaviours through improving the quality (...) of social relationships among employees. (shrink)

Abstract: Background: In spite of the fact that computers continue to improve in speed and functions operation, they remain complex to use. Problems frequently happen, and it is hard to resolve or find solutions for them. This paper outlines the significance and feasibility of building a desktop PC problems diagnosis system. The system gathers problem symptoms from users’ desktops, rather than the user describes his/her problems to primary search engines. It automatically searches global databases of problem symptoms and solutions, and (...) also allows ordinary users to contribute exact problem reports in a structured manner. Objectives: The main goal of this Knowledge Based System is to get the suitable problem desktop PC symptoms and the correct way to solve the errors. Methods: In this paper the design of the proposed Knowledge Based System which was produced to help users of desktop PC in knowing many of the problems and error such as : Power supply problems, CPU errors, RAM dumping error, hard disk errors and bad sectors and suddenly restarting PC. The proposed Knowledge Based System presents an overview about desktop PC hardware errors are given, the cause of fault are outlined and the solution to the problems whenever possible is given out. CLIPS Knowledge Based System language was used for designing and implementing the proposed expert system. Results: The proposed PC desktop troubleshooting Knowledge Based System was evaluated by IT students and they were satisfied with its performance. (shrink)

Evidential Decision Theory is a radical theory of rational decision-making. It recommends that instead of thinking about what your decisions *cause*, you should think about what they *reveal*. This Element explains in simple terms why thinking in this way makes a big difference, and argues that doing so makes for *better* decisions. An appendix gives an intuitive explanation of the measure-theoretic foundations of Evidential Decision Theory.

The objective of this study is to present a new argument for understanding the philosophical roots of Abū al-Qāsim al-Junayd’s (d. 909/297) ambiguous definition of monotheism (tawḥīd). Al-Junayd defines tawḥīd in terms of separating the eternally existing (qadīm) from the temporally generated (muḥdath). This study argues that Plato’s distinction between “that which is and always is” and “that which comes to be and never is” in the Timaeus better clarifies neglected aspects of al-Junayds’s definition than the orthodox Neo-Platonic interpretation put (...) forward by Ali Hassen Abdel Kader. Given the lacuna of historically decisive textual evidence in support of either interpretation, this study will demonstrate how the Platonic distinction, which was widely circulating in the theological and philosophical circles of the ninth and early tenth century Baghdad, better furnishes a more coherent interpretation of al-Junayd’s positions. The first part of the study suggests that al-Junayd’s definition of tawḥīd could best be described as a creatively epistemic appropriation and development of the Platonic essentially metaphysical distinction. Through a careful examination of his theory of self-consciousness, the second part of the study explains how al-Junayd developed his epistemic definition of tawḥīd in response to the charges of pantheism addressed to Sufisms. This examination will further support my claim that a Platonic, rather than a Neo-Platonic, framework better explains the philosophical foundation of al-Junayd’s conception and definition of monotheism. I conclude by indicating how this study’s results contribute to the larger scholarship on philosophy and formation of early Sufism. (shrink)

Generative Artificial Intelligence (AI) tools produce hallucinations exposing developers and users to a myriad of liabilities in courts. Given the absence of strict laws and regulations structuring how Generative AI content interact with potential allegations of defamation, libel, and slander, judges and attorneys are left with the semiotics of the fragmented articles and rules in each system attempting to settle such cases. The endless interpretations of written and non-verbal signs in the law across the world constitutes a new realm for (...) legal semiotics in the area of Generative AI and defamation. The present analysis examines existing civil liability articles in the Jordanian code to shed light on the litigation and defenses afforded in the defamation realm with respect to Generative AI content. The key finding is that like other countries, civil codes in Jordan are outdated concerning Generative AI content opening a plethora of liability scenarios in libel or slander cases. More importantly, the exercise of semiotic interpretation generates several defenses salvaging users and developers under strict sets of conditions. In sum, new amendments and updated legislative frameworks are needed to protect the healthy development of Generative AI while preserving citizens from damaging defamation, libel, and slander. (shrink)

The present study examined how the pre-war debate of the US decision to invade Iraq (in March 2003) was discursively constructed in the US/British mainstream newspaper opinion/editorial (op/ed) argumentation. Drawing on theoretical insights from critical discourse analysis and argumentation theory, I problematised the fallacious discussion used in the pro-war op/eds to build up a ‘moral/legal case’ for war on Iraq based on adversarial (rather than dialogical) argumentation. The proponents of war deployed ‘instrumental rationality’ (ends-justify-means reasoning), ‘ethical necessity’ (Bush’s ‘Preemption Doctrine’) (...) and ‘humanitarian virtue’ (the bombing of Iraq to ‘save’ Iraqis from Saddam’s pestilent tyranny) to justify the pending invasion of Iraq. Their arguments intertextually resonated with Bush administration’s ‘war on terror’ rhetoric in a way that created a form of indexical association through ‘recontextualisation’. The type of arguments marshalled by the pro-war op/ed commentators uncritically bolstered the set of US official ‘truth claims’ and ‘presuppositions’. (shrink)

In recent years, scholars have sought to investigate the impact that ethical leaders can have within organisations. Yet, only a few theoretical perspectives have been adopted to explain how ethical leaders influence subordinate outcomes. This study therefore draws on social rules theory (SRT) to extend our understanding of the mechanisms linking ethical leadership to employee attitudes. We argue that ethical leaders reduce disengagement, which in turn promotes higher levels of job satisfaction and organisational commitment, as well as lower turnover intentions. (...) Co-worker social undermining is examined as a moderator of the relationship between ethical leadership and disengagement, as we suggest that it is difficult for ethical leaders to be effective when co-worker undermining prevails. To test the proposed model, questionnaires were administered to 460 nurses in Romanian hospital settings over three time points separated by two-week intervals and the hypotheses were tested using generalised multilevel structural equation modeling (GSEM) with STATA. The findings revealed that ethical leadership has a beneficial effect on employee attitudes by reducing disengagement. However, the relationship between ethical leadership and disengagement was moderated by co-worker social undermining, such that when undermining was higher, the significance of the mediated relationships disappeared. These results suggest that while ethical leaders can promote positive employee attitudes, their effectiveness is reduced in situations where co-worker undermining exists. (shrink)

Let \(2 (...) It is shown that \(\mathbf{K_n}\) is not finitely axiomatizable and that it coincides with the class of atomic algebras in the elementary closure of \(\mathbf{S_c}{\sf Nr}_n{\sf CA}_{\omega}\) where \(\mathbf{S_c}\) is the operation of forming complete subalgebras. For any class \(\mathbf{L}\) such that \({\sf At}{\sf Nr}_n{\sf CA}_{\omega}\subseteq \mathbf{L}\subseteq {\sf At}\mathbf{K_n}\), it is proved that \({\bf SP}\mathfrak{Cm}\mathbf{L}={\sf RCA}_n\), where \({\sf Cm}\) is the dual operator to \(\sf At\); that of forming complex algebras. It is also shown that any class \(\mathbf{K}\) between \({\sf CRCA}_n\cap \mathbf{S_d}{\sf Nr}_n{\sf CA}_{\omega}\) and \(\mathbf{S_c}{\sf Nr}_n{\sf CA}_{n+3}\) is not first order definable, where \(\mathbf{S_d}\) is the operation of forming dense subalgebras, and that for any \(2shrink)

The risk of cigarette smoking plays a pivotal role in increasing the incidence rates of lung cancer. This paper sheds new light on modeling the impact of cigarette smoking on lung cancer evolution, especially genetic instability and the number of gene mutations in the genome of stem cells. To handle this issue, we have set up stochastic multi-stage models to fit the data set of the probabilities of current and former smokers from the Nurses’ Health Study cohort of females and (...) the Health Professionals Follow up Study cohort of men. Throughout this paper, we consider both mutation rates and clonal expansion rates as parameters in each compartment. For current and former smokers, three-driver mutations are most likely to take place in the progression of lung cancer under smoking risk. For current smokers, our findings reveal that two to sixteen gene mutations are required to obtain a cancerous cell among men and women in US. Moreover, two to six cancer-mutations are available in the pathway to lung cancer among former smokers who have quit smoking for more than ten years for both male and female patients. This highlights that cigarette smoking stimulates the number of driver mutations during lung tumorigenesis in both sexes. It is very crucial to examine the role of cigarette smoking in determining whether genomic instability is an early stage or late stage in the process of lung carcinogenesis. (shrink)

We formulate several statements in Algebraic Logic that turn out to be independent of ZFC. We relate such statements to Martin's axiom, omitting types for variants of first order logic and topological properties of Baire spaces.

Study that try to expose and to define the different types of the language as the juridical, theological, and ascetic-mystical in Miftāḥ al-sa‘āda [Key of Happiness] of Ibn al-‘Arīf. Types that are analyzed in details, to conclude with the influence of the Sufi language of Ibn al-‘Arīf in Ibn ‘Arabī’s work, supporting on considerations of semantic as well as mystical nature.

Este artículo presente y analiza el legado de Abū Madyan cuyas bases van a quedar ilustrado perfectamente en el posterior desarrollo del sufismo andalusi-magrebi de origen šāḏilī y la doctrina de ibn ‘Arabī: traduccion española y estudio critico de las evidencias y cotejos textuales, ensenanzas y practicas espirituales y funcionalidad social.

Looking at the operation of forming neat $\alpha $ -reducts as a functor, with $\alpha $ an infinite ordinal, we investigate when such a functor obtained by truncating $\omega $ dimensions, has a right adjoint. We show that the neat reduct functor for representable cylindric algebras does not have a right adjoint, while that of polyadic algebras is an equivalence. We relate this categorial result to several amalgamation properties for classes of representable algebras. We show that the variety of cylindric (...) algebras of infinite dimension, endowed with the merry go round identities, fails to have the amalgamation property answering a question of Németi’s. We also study two variants of the so-called cylindric polyadic algebras introduced by Ferenczi (all are reducts of polyadic equality algebras, that are also varieties). We show that one is more cylindric than polyadic, and that the other is more polyadic than cylindric. Our classification is determined by results on neat embeddings and amalgamation expressed from the point of view of category theory, thereby witnessing, and, indeed, further emphasizing, the dichotomy between the cylindric and polyadic paradigms. For example, the first class does not have the unique neat embedding property, fails to have the amalgamation property and the neat reduct functor does not have a right adjoint, while the second class has the unique neat emdedding property, the superamalgamation property and the neat reduct functor is strongly invertible. Other results, like first order definability of the class of neat reducts and the class of completely representable algebras, confirming our classification along these lines are presented. (shrink)

Le cri que porte l'intitulé de cet ouvrage est un appel aux lecteurs et aux historiens du Rushdisme à une halte réflexive sur ce que l'auteur appelle cri. Car le cri est une revendication légitime du philosophe. C'est une sorte de voix extra temporelle qui, par fidélité à l'esprit de sa philosophie, s'insurge et déclare que sa pensée a été trahie. Qui est donc ce philosophe à qui on a prêté tant de légendes et commis à son égard tant d'erreurs? (...) Est-ce un grand philosophe réduit au statut de simple commentateur? Ou est-ce une grande méprise à l'égard d'un penseur dont le seul tort est d'avoir voulu sauver le rationalisme philosophique? C'est avec force et détermination que l'auteur de cet essai nous démontre ses convictions sur un personnage historique essentiel, manifestement trop méconnu... Ahmed Mellah est professeur de philosophie. Il a pour ambition de soumettre la philosophie islamique à une analyse critique qui la débarrasserait du dogmatisme institué et autres a priori qui la gangrènent et rendent toute lecture audacieuse totalement inopérante. (shrink)

The market relationships are being contested. This can be seen in the increasing number of alternative social experiments in the ‘North’ and the ‘South’ which propose to think out the present market relationships in a different way, in particular in establishing exchange value and in facilitating access to trade. These practical alternatives are supported by trends in academic circles that over the past three decades have opposed neoliberal capitalism and individualism in today's commercialised society. Calling for greater solidarity and social (...) justice in economic relationships, in particular, partisans of social and solidarity economics, identifying with these trends, demand new forms of exchange. The objective of this article is to re-examine these demands. What exactly do the SSE mean by ‘solidarity’ and ‘solidarity-based economy'? We would like to trace the contours of this theoretical and political project and to assess the practicability of the proposed alternative to neoliberal capitalism. (shrink)

This study aimed to assess the integration, ethical considerations, and governance of artificial intelligence (AI) within the PhD programs at Midocean University. It specifically sought to understand PhD researchers' perceptions and attitudes towards AI and identify areas for enhancement in AI-related policies and educational initiatives. A descriptive analytical approach was adopted, utilizing an electronic questionnaire distributed to 105 PhD researchers, with 54 completing the survey. The questionnaire was designed to measure various aspects of AI usage, ethical concerns, and governance practices. (...) Statistical analysis was conducted to evaluate the relationships between AI awareness, ethical application, and governance perceptions. The findings revealed diverse perceptions of AI among researchers, indicating both opportunities and challenges in AI integration. The statistical analysis confirmed significant correlations between AI awareness and positive perceptions of ethical AI usage. However, the response rate and sample size posed limitations on the generalizability of the results. The study highlights the need for Midocean University to strengthen its AI governance frameworks and expand ethical guidelines to keep pace with technological advancements. Recommendations include enhancing AI-related educational programs, updating AI policies regularly, and promoting interdisciplinary research to foster an informed and ethically aware research community. (shrink)