The risk of cigarette smoking plays a pivotal role in increasing the incidence rates of lung cancer. This paper sheds new light on modeling the impact of cigarette smoking on lung cancer evolution, especially genetic instability and the number of gene mutations in the genome of stem cells. To handle this issue, we have set up stochastic multi-stage models to fit the data set of the probabilities of current and former smokers from the Nurses’ Health Study cohort of females and (...) the Health Professionals Follow up Study cohort of men. Throughout this paper, we consider both mutation rates and clonal expansion rates as parameters in each compartment. For current and former smokers, three-driver mutations are most likely to take place in the progression of lung cancer under smoking risk. For current smokers, our findings reveal that two to sixteen gene mutations are required to obtain a cancerous cell among men and women in US. Moreover, two to six cancer-mutations are available in the pathway to lung cancer among former smokers who have quit smoking for more than ten years for both male and female patients. This highlights that cigarette smoking stimulates the number of driver mutations during lung tumorigenesis in both sexes. It is very crucial to examine the role of cigarette smoking in determining whether genomic instability is an early stage or late stage in the process of lung carcinogenesis. (shrink)

In this note we give an interpretation of cylindric algebras as algebras of sentences of first order logic. We show that the isomorphism types of such algebras of sentences coincide with the class of neat reducts of cylindric algebras. Also we show how this interpretation sheds light on some recent results. This is done by likening Henkin's Neat Embedding Theorem to his celebrated completeness proof.

It is important to design digital infrastructure that can better accommodate multicultural and pluralistic views from its foundations. It is insufficient to look at only the responses and influences of culture on technology without considering how the technology can be adapted in anticipation of, and to support, pluralistic multicultural perspectives in its original design. This goes beyond the simple act of supporting multiple languages and interfaces, but should include the ability of digital and data infrastructure to capture and accommodate pluralistic (...) views, supporting multiple perspectives in the representation and processing of the data itself. In this work, we look at how rethinking the representation of data can allow us to more directly tackle domains that are typically hampered due to intercultural differences, and their inevitable losses in translation, particularly losses of valuable information like context and intention. When we refer to a loss of context and intention, we are referring to the loss of semantic information when practices such as referencing and citation are hard-coded to a particular set of cultural norms. We show that it is possible to expand the way in which we track referential data to capture richer semantic information regarding the contexts and intentions of the creators of this data, and thereby better serve the varied needs of those who consume, study, and refer to such data. We demonstrate this concept through a prototype system for a multicultural digital infrastructure, which we have namedMultiVerse, and discuss its ethical implications from the perspectives of ‘multistability’, Intercultural Information Ethics framework, and poststructuralism. (shrink)

BackgroundOrgan donation has become one of the most effective ways to save lives and improve the quality of life for patients with end-stage organ failure. No previous studies have investigated the preferences for the different consenting options for organ donation in Egypt. This study aims to assess Egyptians’ preferences regarding consenting options for posthumous organ donation, and measure their awareness and acceptance of the Egyptian law articles regulating organ donation.MethodsA cross sectional study was conducted among 2743 participants over two years. (...) Each participant was required to rank eleven consenting options from 1 to 11, and to report his awareness and acceptance of the seven articles of the Egyptian law of organ donation.Results47% of the participants expressed willingness to donate their organs after death. This percentage increased to 78% when consenting options were explained to participants. “Informed consent by donor only” was the most preferred type of consent for one third of respondents. Awareness of the law articles regulating organ donation was relatively low ranging from 56% to 23%.ConclusionCurrently, around half of the Egyptian population agree to posthumous organ donation. This percentage could be increased significantly by raising the awareness about how the process of donation could be regulated and how the patient’s right of decision could be protected. (shrink)

Background Posthumous organ procurement is hindered by the consenting process. Several consenting systems have been proposed. There is limited information on public relative attitudes towards various consenting systems, especially in Middle Eastern/Islamic countries. Methods We surveyed 698 Saudi Adults attending outpatient clinics at a tertiary care hospital. Preference and perception of norm regarding consenting options for posthumous organ donation were explored. Participants ranked (1, most agreeable) the following, randomly-presented, options from 1 to 11: no-organ-donation, presumed consent, informed consent by donor-only, (...) informed consent by donor-or-surrogate, and mandatory choice; the last three options ± medical or financial incentive. Results Mean(SD) age was 32(9) year, 27% were males, 50% were patients’ companions, 60% had ≥ college education, and 20% and 32%, respectively, knew an organ donor or recipient. Mandated choice was among the top three choices for preference of 54% of respondents, with an overall median[25%,75%] ranking score of 3[2,6], and was preferred over donor-or-surrogate informed consent (4[2,7], p vs. 11[6,11], respectively, p = 0.002). Compared to females, males more perceived donor-or-surrogate informed consent as the norm (3[1,6] vs. 5[3,7], p vs. 8[4,9], p vs. 5[2,7], p Conclusions We conclude that: 1) most respondents were in favor of posthumous organ donation, 2) mandated choice system was the most preferred and presumed consent system was the least preferred, 3) there was no difference between preference and perception of norm in consenting systems ranking, and 4) financial (especially in females) and medical (especially in males) incentives reduced preference. (shrink)

Abstract: Background: In spite of the fact that computers continue to improve in speed and functions operation, they remain complex to use. Problems frequently happen, and it is hard to resolve or find solutions for them. This paper outlines the significance and feasibility of building a desktop PC problems diagnosis system. The system gathers problem symptoms from users’ desktops, rather than the user describes his/her problems to primary search engines. It automatically searches global databases of problem symptoms and solutions, and (...) also allows ordinary users to contribute exact problem reports in a structured manner. Objectives: The main goal of this Knowledge Based System is to get the suitable problem desktop PC symptoms and the correct way to solve the errors. Methods: In this paper the design of the proposed Knowledge Based System which was produced to help users of desktop PC in knowing many of the problems and error such as : Power supply problems, CPU errors, RAM dumping error, hard disk errors and bad sectors and suddenly restarting PC. The proposed Knowledge Based System presents an overview about desktop PC hardware errors are given, the cause of fault are outlined and the solution to the problems whenever possible is given out. CLIPS Knowledge Based System language was used for designing and implementing the proposed expert system. Results: The proposed PC desktop troubleshooting Knowledge Based System was evaluated by IT students and they were satisfied with its performance. (shrink)

Introduction: find your way -- Orientations toward objects -- Sexual orientation -- The orient and other others -- Conclusion: disorientation and queer objects.

Il ne suffit pas d'attribuer une âme aux plantes et aux animaux pour soigner les ravages de l'extractivisme. Encore faut-il élargir le spectre des non-humains au-delà du visible. Dragons et êtres souterrains, lieux des rêves ou réalités ultimes tiennent une place centrale dans les traditions vivantes qui peuplent cette terre. Pour vraiment les écouter, il est temps de rompre avec toute une série de présupposés qui encombrent l'anthropologie, à commencer par l'idée que les 'indigènes' demeureraient inconscients des structures qui régissent (...) leur vie collective. Afin de mettre en œuvre une 'décolonisation des savoirs,' ce livre invite à assumer la part métaphysique de la pensée et du réel. Seul un contact philosophique avec l'invisible, une pensée de ce qui se trouve au bord des mondes, permettra une double critique féconde--aussi bien des limites de la modernité que des traditionalismes qui s'exercent au nom de Dieu. Et s'il fallait à nouveau visiter le ciel pour réhabiliter la terre? Cet essai propose une perspective novatrice qui bouleverse les lieux communs de la pensée écologique et des sciences sociales.."--Back cover. (shrink)

Buildings energy consumption is growing gradually and put away around 40% of total energy use. Predicting heating and cooling loads of a building in the initial phase of the design to find out optimal solutions amongst different designs is very important, as ell as in the operating phase after the building has been finished for efficient energy. In this study, an artificial neural network model was designed and developed for predicting heating and cooling loads of a building based on a (...) dataset for building energy performance. The main factors for input variables are: relative compactness, roof area, overall height, surface area, glazing are a, wall area, glazing area distribution of a building, orientation, and the output variables: heating and cooling loads of the building. The dataset used for training are the data published in the literature for various 768 residential buildings. The model was trained and validated, most important factors affecting heating load and cooling load are identified, and the accuracy for the validation was 99.60%. (shrink)

The best-known argument for Evidential Decision Theory (EDT) is the ‘Why ain’cha rich?’ challenge to rival Causal Decision Theory (CDT). The basis for this challenge is that in Newcomb-like situations, acts that conform to EDT may be known in advance to have the better return than acts that conform to CDT. Frank Arntzenius has recently proposed an ingenious counter argument, based on an example in which, he claims, it is predictable in advance that acts that conform to EDT will do (...) less well than acts that conform to CDT. We raise two objections to Arntzenius’s example. We argue, first, that the example is subtly incoherent, in a way that undermines its effectiveness against EDT; and, second, that the example relies on calculating the average return over an inappropriate population of acts. (shrink)

Cette monographie porte sur la question de la connaissance dans le commentaire coranique de Fakhr al-Dīn al-Rāzī. Ahmed Oulddali y étudie, à travers plusieurs sources, les théories psychologiques et épistémologiques sur lesquelles cet exégète sunnite fonde son interprétation du Coran. This monograph addresses the question of knowledge in Faḫr al-Dīn al-Rāzī's Qurʾān commentary. Utilizing a variety of sources, Ahmed Oulddali presents the psychological and epistemological theories on which this Sunni exegete bases his interpretation of the Qurʾān.

Feminism is sensational -- On being directed -- Willfulness and feminist subjectivity -- Trying to transform -- Being in question -- Brick walls -- Fragile connections -- Feminist snap -- Lesbian feminism -- Conclusion 1: A killjoy survival kit -- Conclusion 2: A killjoy manifesto.

Differences That Matter challenges existing ways of theorising the relationship between feminism and postmodernism which ask 'is or should feminism be modern or postmodern?' Sara Ahmed suggests that postmodernism has been allowed to dictate feminist debates and calls instead for feminist theorists to speak (back) to postmodernism, rather than simply speak on (their relationship to) it. Such a 'speaking back' involves a refusal to position postmodernism as a generalisable condition of the world and requires closer readings of what postmodernism (...) is actually 'doing' in a variety of disciplinary contexts. Sara Ahmed hence examines constructions of postmodernism in relation to rights, ethics, subjectivity, authorship, meta-fiction and film. (shrink)

The paper suggests that we can usefully approach whiteness through the lens of phenomenology. Whiteness could be described as an ongoing and unfinished history, which orientates bodies in specific directions, affecting how they `take up' space, and what they `can do'. The paper considers how whiteness functions as a habit, even a bad habit, which becomes a background to social action. The paper draws on experiences of inhabiting a white world as a non-white body, and explores how whiteness becomes worldly (...) through the noticeability of the arrival of some bodies more than others. A phenomenology of whiteness helps us to notice institutional habits; it brings what is behind to the surface in a certain way. (shrink)

In What's the Use? Sara Ahmed continues the work she began in The Promise of Happiness and Willful Subjects by taking up a single word--in this case, use--and following it around. She shows how use became associated with life and strength in nineteenth century biological and social thought and considers how utilitarianism offered a set of educational techniques for shaping individuals by directing them toward useful ends. Ahmed also explores how spaces become restricted to some uses and users (...) with specific reference to universities. She notes, however, the potential for queer use: how things can be used in ways that were not intended or by those for whom they were not intended. Ahmed posits queer use as way of reanimating the project of diversity work as the ordinary and painstaking work of opening up institutions to those who have historically been excluded from them. (shrink)

n this paper, a non-classical axiomatic system was introduced to classify all moods of Aristotelian syllogisms, in addition to the axiom "Every a is an a" and the bilateral rules of obversion of E and O propositions. This system consists of only 2 definitions, 2 axioms, 1 rule of a premise, and moods of Barbara and Datisi. By adding first-degree propositional negation to this system, we prove that the square of opposition holds without using many of the other rules of (...) classical logic (including double negation elimination). We then show that the Propositional Substructural Logic SLe is the best logic to study Aristotelian Syllogisms. Also, based on the IFLe square of opposition, the rules of conversation and the rules of negation are completely proved in Muzaffar's logic. For this purpose, we used the monadic first-order logic with the same standard deductive apparatus of quantifiers in classical logic, plus the axioms of "some a is an a" and "some not-a is a not-a". Finally, to show that there is no existential commitment to general terms in categorical logic, the Strong Four-Valued Relevant-classical Logic KR4 was used. With the same existential interpretation of the quantifiers and the standard translation of the quarter quantified. (shrink)

Contrary to what is stated in Lemma 7.1 of [8], it is shown that some Boolean algebras of finitary logic admit finitely additive probabilities that are not σ-additive. Consequences of Lemma 7.1 are reconsidered. The concept of a C-σ-additive probability on B (where B and C are Boolean algebras, and $\mathscr{B} \subseteq \mathscr{C}$ ) is introduced, and a generalization of Hahn's extension theorem is proved. This and other results are employed to show that every S̄(L)-σ-additive probability on s̄(L) can be (...) extended (uniquely, under some conditions) to a σ-additive probability on S̄(L), where L belongs to a quite extensive family of first order languages, and S̄(L) and s̄(L) are, respectively, the Boolean algebras of sentences and quantifier free sentences of L. (shrink)

Le cri que porte l'intitulé de cet ouvrage est un appel aux lecteurs et aux historiens du Rushdisme à une halte réflexive sur ce que l'auteur appelle cri. Car le cri est une revendication légitime du philosophe. C'est une sorte de voix extra temporelle qui, par fidélité à l'esprit de sa philosophie, s'insurge et déclare que sa pensée a été trahie. Qui est donc ce philosophe à qui on a prêté tant de légendes et commis à son égard tant d'erreurs? (...) Est-ce un grand philosophe réduit au statut de simple commentateur? Ou est-ce une grande méprise à l'égard d'un penseur dont le seul tort est d'avoir voulu sauver le rationalisme philosophique? C'est avec force et détermination que l'auteur de cet essai nous démontre ses convictions sur un personnage historique essentiel, manifestement trop méconnu... Ahmed Mellah est professeur de philosophie. Il a pour ambition de soumettre la philosophie islamique à une analyse critique qui la débarrasserait du dogmatisme institué et autres a priori qui la gangrènent et rendent toute lecture audacieuse totalement inopérante. (shrink)

Great critical theorists from Marx and Engels to Adorno and Horkheimer not only came from the margins but also stayed faithful to the plight of the marginalized. They refused to compromise about the struggle for equality and tried to universalize its emancipatory essence. From Marx to Benjamin, critical philosophers who showed fidelity to the cause were denied a career in European universities and made impoverished, stateless, and homeless. Marginalization and critical theory are inseparable; yet, today, Marxism is institutionalized, and the (...) Frankfurt School's Critical Theory is gentrified. Critical Theory from the Margins, however, revives the Critical Theory that endorses criticism, aiming to negate dominant regimes of truth. It is unapologetic in its fidelity to the universalist struggles of the minoritized. In that spirit, Saladdin Ahmed shows that capitalism imposes a totalitarian social mode of existence and neoliberalism perpetuates fascism as a class of ideology across nationalist and religious movements. This book, then, is both a theorization and an argument in favor of the application of the episteme of the silenced as the essence of the critical education necessary for achieving universal emancipation. (shrink)

Evidential Decision Theory is a radical theory of rational decision-making. It recommends that instead of thinking about what your decisions *cause*, you should think about what they *reveal*. This Element explains in simple terms why thinking in this way makes a big difference, and argues that doing so makes for *better* decisions. An appendix gives an intuitive explanation of the measure-theoretic foundations of Evidential Decision Theory.

This is a survey article on algebraic logic. It gives a historical background leading up to a modern perspective. Central problems in algebraic logic (like the representation problem) are discussed in connection to other branches of logic, like modal logic, proof theory, model-theoretic forcing, finite combinatorics, and Gödel’s incompleteness results. We focus on cylindric algebras. Relation algebras and polyadic algebras are mostly covered only insofar as they relate to cylindric algebras, and even there we have not told the whole story. (...) We relate the algebraic notion of neat embeddings (a notion special to cylindric algebras) to the metalogical ones of provability, interpolation and omitting types in variants of first logic. Another novelty that occurs here is relating the algebraic notion of atom-canonicity for a class of boolean algebras with operators to the metalogical one of omitting types for the corresponding logic. A hitherto unpublished application of algebraic logic to omitting types of first order logic is given. Proofs are included when they serve to illustrate certain concepts. Several open problems are posed. We have tried as much as possible to avoid exploring territory already explored in the survey articles of Monk [93] and Németi [97] in the subject. (shrink)

The best justification of time-discounting is roughly that it is rational to care less about your more distant future because there is less of you around to have it. I argue that the standard version of this argument, which treats both psychological continuity and psychological connectedness as reasons to care about your future, can only rationalize an irrational—because exploitable—form of future discounting.

This paper argues that evidential decision theory is incompatible with options having objective values. If options have objective values, then it should always be rationally permissible for an agent to choose an option if they are certain that the option uniquely maximizes objective value. But, as we show, if options have objective values and evidential decision theory is true, then it is not always rationally permissible for an agent to choose an option if they are certain that the option uniquely (...) maximizes objective value. (shrink)

For first order languages with no individual constants, empty structures and truth values (for sentences) in them are defined. The first order theories of the empty structures and of all structures (the empty ones included) are axiomatized with modus ponens as the only rule of inference. Compactness is proved and decidability is discussed. Furthermore, some well known theorems of model theory are reconsidered under this new situation. Finally, a word is said on other approaches to the whole problem.

La traducción de la obra principal de Maimónides, la Guía de los descarriados, del árabe al hebreo tuvo repercusiones amplias y prolongadas. Provocó una crisis social en el seno de las comunidades judías en dominios cristianos, abrió las puertas al conocimiento de la filosofía de Averroes y de Aristóteles entre los judíos, y dio lugar a una corriente averroísta judía, y a su oposición. Dado que Algacel representa una posición tradicional contraria a la filosofía, y combatida por Averroes, hahlane sostiene (...) que el interés dentro de la comunidad judía por Algacel es debido su utilidad en la polémica interna contra Averroes y Maimónides. (shrink)

Alzheimer’s Disease (AD) and Autism Spectrum Disorder (ASD) represent two distinct but equally impactful challenges in the field of neurology and cognitive health. AD is a degenerative neurological condition characterized by its progressive nature, typically affecting individuals in later stages of life. The hallmark features include cognitive impairment, mem- ory deterioration, and alterations in behavior. In contrast, ASD is a developmental disorder typically diagnosed in childhood, marked by difficulties in social interaction, communication, and repetitive behaviors. This paper explores the potential (...) of the time-frequency feature extraction model known as the Left-Right Fast Fourier Transform (LR-FFT) in the context of these two disorders. While AD and ASD differ significantly in their onset, presentation, and demographic affected, both necessitate early and accurate diagnosis to enable timely intervention and tailored treatment strategies. Our research yields promising results, with classification accuracies reaching 88.26% for AD and 99.86% for ASD, demonstrating the LR-FFT’s potential to enhance diagnostic accuracy. By contributing to improved differentiation between these complex neurological conditions, this work aims to advance our understanding and management of AD and ASD, ultimately benefiting patients, their families, and healthcare practitioners. (shrink)

The paper depicts the blueprint of an electronic wise indicating system for demonstrating learning French to understudies to overcome the inconveniences they go up against. The fundamental idea of this structure is a proficient introduction into learning French. The system shows the purpose of learning French and coordinates thusly made issues for the understudies to clarify. The system is logically balanced at run time to the understudy’s individual progress. The system gives unequivocal help to adaptable presentation to learners.

In lieu of an abstract, here is a brief excerpt of the content:Finding PartnershipThe Benefit of Sharing and the Capacity for ComplexityMichaela Amering (bio)Keywordsrecovery, empowerment, trialog, user involvement, schizophreniaIs There Ignorance and Arrogance? In Psychiatry? In Medicine?Adding insight to injury' is the paraphrase psychiatrist Pat McGorry (1992) coined for his reproach of 'pushing for "insight" or "acceptance of diagnosis"' without carefully taking into account the complexities of the individual situation, context, and needs. That must be about the kind of behavior (...) Marga Reimer has in mind in her paper on treatment adherence in the absence of insight, which depicts mental health professionals characterized by arrogance against the common sense of motivating compliance by perceived or anticipated benefits on different everyday life levels, but instead trying to get people to believe in a mental illness such as schizophrenia and wishing them to want treatment for that in the form of medication.In addition, Reimer presents examples from general medicine to make her point that adherence follows perceived or anticipated benefits instead of being a result of insight into a medical model of illness and McGorry (1992) also suggests that disregard for the active role that patients may play as reflected in psychiatry in terms such as 'case management' and 'compliance' "is a failing which extends to mainstream medicine and probably to most systems of human service delivery." On the other hand, Bill Anthony (2006), one of the most eminent experts on psychiatric rehabilitation and recovery in a personal report on his own medical illness, multiple sclerosis—MS, and the assistance he has been receiving in connection with it, describes the 'MS-Community' as exemplary with respect to instilling courage and hope, continually providing information and opportunities for exchange, and for never questioning a person's ultimate freedom of choice. In contrary, in mental health care he does not experience the medical profession as acting with full respect and support for its patients and suggests a great deal more work and transformation—especially concerning coercive treatments—ahead to follow this example. Similarly, it has been suggested that psychiatry should be better integrated into medicine to overcome stigma and discrimination of psychiatric health problems and interventions. A pertinent example of an initiative in this direction is the proposal of a fusion of mental health and incapacity legislation to arrive at ethically consistent legal situations with regard to involuntary [End Page 77] treatment across medicine (Dawson and Szmukler 2006).Is There Something Called Schizophrenia? and How Much Longer?Reimer's main example—schizophrenia—is the diagnosis that poses some of the greatest problems to the field and to the recognition of psychiatry as a scientific medical discipline. The current concept as well as the term 'schizophrenia' will probably not be around much longer; 'a century of schizophrenia is enough' (Kelly and Murray 2002). Suggested solutions for the problems of the diagnosis of schizophrenia concern the urgent complement of the categorical with a dimensional approach (Allardyce et al. 2007), a change also put forward as one of the essential remedies to undermine the stigma of mental illness that is often exacerbated by clinical diagnosis (Corrigan 2007). Such a move would also clearly help against the still prevalent experiences of users of services and their families and friends, whose hopes and dreams have been crushed and whose resilience has been undermined by clinical situations, which in times of psychotic crises, not only forced diagnoses but also prognoses—often scientifically unfounded—on them (Amering and Schmolke 2009).Is There a Solution? Can We Use Our Talents? And Those of People With a Lived Experience of Mental Health Problems and Care?Clinicians as well as scientists know that health, illness, and recovery occur in complex ways and contexts. People faced with mental health problems clearly realize the complexities of their situation and are especially motivated to appreciate the variety of factors and interactions that need to be integrated to arrive at a valid assessment. Ideally, the therapeutic relationship—essentially a partnership—holds a formidable chance of sharing efforts and creating the wisdom for finding and facing the truths necessary to develop solutions that can uphold and work in line with the complexities of human life.I would argue that psychiatric professionals are certainly part... (shrink)

To examine how different ownership structures, varying from diverse ownership bases to narrow ownership bases, influence the extent of corporate social responsibility (CSR) reporting by companies in emerging market. The motivation for this study is the reported inconsistent results for this association in developing countries and the lack of research in emerging markets. Eight hundred observations of 80 nonfinancial sector listed companies in the Amman Stock Exchange for the period 2006 to 2015 were used for a content analysis to assess (...) the extent of CSR reporting. Ordinary least square multiple regression analysis was undertaken to examine the association between five different ownership structures and their extent of CSR reporting. The results reveal three separate associations between the types of ownership and the extent of CSR reporting. First, the two types of ownership (foreign and government) have a significant and positive influence on the extent of CSR reporting. Second, another two types of ownership (Family and managerial) have a significantly negative association. Finally, institutional ownership has an insignificant and negligible influence on the extent of CSR reporting. These findings provide insights into how ownership structure influences the CSR reporting extent by emerging market companies such as Jordan. These findings suggest that policy makers, regulatory bodies, companies, and investors should increase their awareness about how different concentration of company ownership influences the extent companies voluntarily disclose CSR reporting. The evidence adds to the limited body of knowledge about different ownership groups' influence on the extent of CSR reporting in a developing country because few empirical studies have undertaken such a comprehensive analysis of this association. (shrink)