I develop an account of the relationship between aesthetics and knowledge, focusing on scientific practice. Cognitivists infer from ‘partial sensitivity’—aesthetic appreciation partly depends on doxastic states—to ‘factivity’, the idea that the truth or otherwise of those beliefs makes a difference to aesthetic appreciation. Rejecting factivity, I develop a notion of ‘epistemic engagement’: partaking genuinely in a knowledge-directed process of coming to epistemic judgements, and suggest that this better accommodates the relationship between the aesthetic and the epistemic. Scientific training (and other (...) knowledge-directed activities), I argue, involves ‘attunement’: the co-option of aesthetic judgements towards epistemic ends. Thus, the connection between aesthetic appreciation and knowledge is psychological and contingent. This view has consequences for the warrant of aesthetic judgement in science, namely, the locus of justification is those processes of attunement, not the aesthetic judgements themselves. (shrink)

Despite wide recognition that speculation is critical for successful science, philosophers have attended little to it. When they have, speculation has been characterized in narrowly epistemic terms: a hypothesis is speculative due to its (lack of) evidential support. These ‘evidence-first’ accounts provide little guidance for what makes speculation productive or egregious, nor how to foster the former while avoiding the latter. I examine how scientists discuss speculation and identify various functions speculations play. On this basis, I develop a ‘function-first’ account (...) of speculation. This analysis grounds a richer discussion of when speculation is egregious and when it is productive, based in both fine-grained analysis of the speculation’s purpose, and what I call the ‘epistemic situation’ scientists face. (shrink)

An understanding of the factors behind the evolution of multicellularity is one of today’s frontiers in evolutionary biology. This is because multicellular organisms are made of one subset of cells with the capacity to transmit genes to the next generation and another subset responsible for maintaining the functionality of the organism, but incapable of transmitting genes to the next generation. The question arises: why do somatic cells sacrifice their lives for the sake of germline cells? How is germ/soma separation maintained? (...) One conventional answer refers to inclusive fitness theory, according to which somatic cells sacrifice themselves altruistically, because in so doing they enhance the transmission of their genes by virtue of their genetic relatedness to germline cells. In the present article we will argue that this explanation ignores the key role of policing mechanisms in maintaining the germ/soma divide. Based on the pervasiveness of the latter, we argue that the role of altruistic mechanisms in the evolution of multicellularity is limited and that our understanding of this evolution must be enriched through the consideration of coercion mechanisms. (shrink)

Debate about the epistemic prowess of historical science has focused on local underdetermination problems generated by a lack of historical data; the prevalence of information loss over geological time, and the capacities of scientists to mitigate it. Drawing on Leonelli’s recent distinction between ‘phenomena-time’ and ‘data-time’ I argue that factors like data generation, curation and management significantly complexifies and undermines this: underdetermination is a bad way of framing the challenges historical scientists face. In doing so, I identify circumstances of epistemic (...) scarcity where underdetermination problems are particularly salient, and discuss cases where legacy data—data generated using differing technologies and systems of practice—are drawn upon to overcome underdetermination. This suggests that one source of overcoming underdetermination is our knowledge of science’s past. Further, data-time makes agnostic positions about the epistemic fortunes of scientists working under epistemic scarcity more plausible. But agnosticism seems to leave philosophers without much normative grip. So, I sketch an alternative approach: focusing on the strategies scientists adopt to maximize their epistemic power in light of the resources available to them. (shrink)

A growing body of empirical evidence suggests that folk knowledge attribution practices regarding some epistemological thought experiments differ significantly from the consensus found in the philosophical literature. More specifically, laypersons are likely to ascribe knowledge in the so-called Authentic Evidence Gettier-style cases, while most philosophers deny knowledge in these cases. The intuitions shared by philosophers are often used as evidence in favor (or against) certain philosophical analyses of the notion of knowledge. However, the fact that these intuitions are not universal, (...) as non-philosophers do not sympathize with verdicts made by philosophers, is problematic and requires some explanation. Recently, a promising theoretical approach emerged that could be used to explain away unexpected folk knowledge attributions. According to the protagonist projection hypothesis, when subjects answer questions about some hypothetical scenario, their judgments might result from adopting the cognitive perspective of the protagonist in the given scenario. Previous experimental findings suggest protagonist projection might be responsible for problematic knowledge attributions in Gettier-style cases. This paper reports data collected in an experiment which focused on five different Authentic Evidence Gettier-style scenarios and investigated the impact of protagonist projection on folk knowledge ascriptions in such cases. The results bring some support to the protagonist projection hypothesis, but do not allow to explain away a substantial number of problematic folk knowledge attributions. (shrink)

Historical sciences like paleontology and archaeology have uncovered unimagined, remarkable and mysterious worlds in the deep past. How should we understand the success of these sciences? What is the relationship between knowledge and history? In Scientific Knowledge and the Deep Past: History Matters, Adrian Currie examines recent paleontological work on the great changes that occurred during the Cretaceous period - the emergence of flowering plants, the splitting of the mega-continent Gondwana, and the eventual fall of the dinosaurs - to (...) analyse the knowledge of historical scientists, and to reflect upon the nature of history. He argues that distinctively historical processes are 'peculiar': they have the capacity to generate their own highly specific dynamics and rules. This peculiarity, Currie argues, also explains the historian's interest in narratives and stories: the contingency, complexity and peculiarity of the past demands a narrative treatment. Overall, Currie argues that history matters for knowledge. (shrink)

Dialogue has its origins in joint activities, which it serves to coordinate. Joint activities, in turn, usually emerge in hierarchically nested projects and subprojects. We propose that participants use dialogue to coordinate two kinds of transitions in these joint projects: vertical transitions, or entering and exiting joint projects; and horizontal transitions, or continuing within joint projects. The participants help signal these transitions with project markers, words such as uh-huh, m-hm, yeah, okay, or all right. These words have been studied mainly (...) as signals of listener feedback (back-channel signals) or turn-taking devices (acknowledgment tokens). We present evidence from several types of well-defined tasks that they are also part of a system of contrasts specialized for navigating joint projects. Uh-huh, m-hm and yeah are used for horizontal transitions, and okay and all right for vertical transitions. (shrink)

The history of economic thought witnessed several prominent economists who took seriously models and concepts in physics for the elucidation and prediction of economic phenomena. Econophysics is an emerging discipline at the intersection of heterodox economics and the physics of complex systems, with practitioners typically engaged in two overlapping but distinct methodological programs. The first is to export mathematical methods used in physics for the purposes of studying economic phenomena. The second is to export mechanisms in physics into economics. A (...) conclusion is drawn that physics transfer is often justified at the level of mathematical transfer but unjustified at the level of mechanistic transfer. (shrink)

I develop an account of productive surprise as an epistemic virtue of scientific investigations which does not turn on psychology alone. On my account, a scientific investigation is potentially productively surprising when results can conflict with epistemic expectations, those expectations pertain to a wide set of subjects. I argue that there are two sources of such surprise in science. One source, often identified with experiments, involves bringing our theoretical ideas in contact with new empirical observations. Another, often identified with simulations, (...) involves articulating and bringing together different parts of our knowledge. Both experiments and simulations, then, can surprise. (shrink)

Earthbodies describes how our bodies are open circuits to a sensual magic and planetary care that when closed off leads to disastrous detours, such as illness, ...

The Received View of particles in quantum mechanics is that they are indistinguishable entities within their kinds and that, as a consequence, they are not individuals in the metaphysical sense and self-identity does not meaningfully apply to them. Nevertheless cardinality does apply, in that one can have n> 1 such particles. A number of authors have recently argued that this cluster of claims is internally contradictory: roughly, that having more than one such particle requires that the concepts of distinctness and (...) identity must apply after all. A common thread here is that the notion of identity is too fundamental to forego in any metaphysical account. I argue that this argument fails. I then argue that the failure of individuality and identity applies also to macroscopic physical objects, that the problems cannot be constrained to apply only within the microscopic realm. (shrink)

This is the first and only dictionary dedicated to the work of Gilles Deleuze. It provides an in-depth and lucid introduction to one of the most influential figures in continental philosophy. It defines and contextualises more than 150 terms that relate to Deleuze's philosophy and explains the main intellectual influences on Deleuze as well as the influence Deleuze has had on subjects such as feminism, cinema, postcolonial theory, geography and cultural studies. In this revised edition, there are expanded entries on (...) architecture, cinema and psychoanalysis - key areas where interest in Deleuze has grown in recent years. (shrink)

The empiricist needs to explain the origin, in perception, of the idea of time. Kant believed the only answer was a kind of idealism about time. This essay examines Hume’s extensionalism as a possible answer to Kant. Extensionalism allegedly accounts for the experience of time via the manner of presentation of experiences, rather than the content of experience.

The paper proposes a novel solution to the problem of scope posed by natural language indefinites that captures both the difference in scopal freedom between indefinites and bona fide quantifiers and the syntactic sensitivity that the scope of indefinites does nevertheless exhibit. Following the main insight of choice functional approaches, we connect the special scopal properties of indefinites to the fact that their semantics can be stated in terms of choosing a suitable witness. This is in contrast to bona fide (...) quantifiers, the semantics of which crucially involves relations between sets of entities. We provide empirical arguments that this insight should not be captured by adding choice/Skolem functions to classical first-order logic, but in a semantics that follows Independence-Friendly Logic, in which scopal relations involving existentials are part of the recursive definition of truth and satisfaction. These scopal relations are resolved automatically as part of the interpretation of existentials. Additional support for this approach is provided by dependent indefinites, a cross-linguistically common class of special indefinites that can be straightforwardly analyzed in our semantic framework. (shrink)

The paper proposes the first unified account of deictic/sentence-external and sentence-internal readings of singular different . The empirical motivation for such an account is provided by a cross-linguistic survey and an analysis of the differences in distribution and interpretation between singular different , plural different and same (singular or plural) in English. The main proposal is that distributive quantification temporarily makes available two discourse referents within its nuclear scope, the values of which are required by sentence-internal uses of singular different (...) to be distinct, much as its deictic uses require the values of two discourse referents to be distinct. Thus, we take sentence-internal readings to be a form of ‘association with distributivity’ that is similar to association with focus. The contrast between singular different , plural different and same is explained in terms of several kinds of quantificational distributors that license their internal readings. The analysis is executed in a stack-based dynamic system couched in type logic, so we get compositionality in the usual Montagovian way. Quantificational subordination and dependent indefinites in various languages provide additional motivation for the account. Investigating the connections between items with sentence-internal readings and the quantificational licensors of these readings opens up a larger project of formally investigating (i) the typology of quantificational distributors and distributivity-dependent items and (ii) the fine-grained contexts of evaluation needed to capture this typological variation. (shrink)

From a behaviorist perspective, the desire to upload “minds” is already being realized on a mass, hyper-industrial scale thanks to the convergence of cognitive computing and Big Data. The accusation is that the “mind” is not an entity that exists intracranially. Instead, it is conceived as a process of individuation, which occurs in different modes and numbers. Some narratives of mind-uploading and technics in popular culture are explored: Transcendence (2014, dir. Wally Pfister) and Player Piano by Kurt Vonnegut. The discussed (...) issues consider Bernard Stiegler’s phenomenological notion of originary default and Thierry Bardini’s analysis of junk. Several questions are raised regarding miscalculations, accidents, in addition to Nicolas Agar’s discussion on the end of humanity, and Daniel Dennett’s Multiple Drafts theory within the context of exteriorization, which is considered as constitutive of interiority. (shrink)

It has become almost a cliché to say that we live in a post-truth world; that people of all trades speak with an indifference to truth. Speaking with an indifference to how things really are is famously regarded by Harry Frankfurt as the essence of bullshit. This paper aims to contribute to the philosophical and theoretical pragmatics discussion of bullshit. The aim of the paper is to offer a new theoretical analysis of what bullshit is, one that is more encompassing (...) than Frankfurt’s original characterization. I part ways with Frankfurt in two points. Firstly, I propose that we should not analyze bullshit in intentional terms (i.e. as indifference). Secondly, I propose that we should not analyze it in relation to truth. Roughly put, I propose that bullshit is best characterized as speaking with carelessness toward the evidence for one’s conversational contribution. I bring forward, in the third section, a battery of examples that motivate this characterization. Furthermore, I argue that we can analyze speaking with carelessness toward the evidence in Gricean terms as a violation of the second Quality maxim. I argue that the Quality supermaxim, together with its subordinate maxims, demand that the speaker is truthful (contributes only what she believes to be true) and reliable (has adequate evidence for her contribution). The bullshitter’s main fault lies in being an unreliable interlocutor. I further argue that we should interpret what counts as adequate evidence, as stipulated by the second Quality Maxim, in contextualist terms: the subject matter and implicit epistemic standards determine how much evidence one needs in order to have adequate evidence. I contrast this proposed reading with a subjectivist interpretation of what counts as having adequate evidence and show that they give different predictions. Finally, working with a classic distinction, I argue that we should not understand bullshit as a form of deception but rather as a form of misleading speech. (shrink)

There has been considerable discussion in the literature of one kind of identity problem that mathematical structuralism faces: the automorphism problem, in which the structure is unable to individuate the mathematical entities in its domain. Shapiro (Philos Math 16(3):285–309, 2008) has partly responded to these concerns. But I argue here that the theory faces an even more serious kind of identity problem, which the theory can’t overcome staying within its remit. I give two examples to make the point.

Cases of 'convergence' could play an important role in the construction and corroboration of adaptive hypotheses. In particular, they could inform us about the evolutionary histories of novel traits. However, there is a problem of causal depth in the use of analogies. Natural Selection's affect on phenotype is constrained by phylogenetic history to a degree that we are unfounded in projecting adaptive stories from one lineage to another. I will argue for two approaches to resolve this issue. First, by constraining (...) our catchment area to closely related lineages we can control for developmental noise. Second, by integrating analogies into explanations which incorporate other streams of evidence or bootstrapping an analogous model across many instantiations, we can overcome the problem of causal depth. (shrink)

Socialists and defenders of laissez-faire share the view that in the market agents pursue their self-interest, not the good of others. On this basis, socialists reject the market as an arena of immorality, while laissez-faire theorists attempt to defuse the charge by relying on the providential consequences of the "invisible hand," However, both stances presuppose a view of morality that too sharply separates self-interest and altruism. Some try to separate the economic arui morality into discrete spheres. In contrast, a compatibilist (...) account shows the ways a concern for personal profit and a concern for others can come together. Such a motivationalist approach allows one to re-conceive the "invisible hand." It is no longer a serendipitous justification of the merely self-interested, but an invitation to think of the various mixtures of altruism and self-interest required to produce those results that may commend the market. (shrink)

The superassertability theory of truth, inspired by Crispin Wright (1992, 2003), holds that a statement is true if and only if it is superassertable in the following sense: it possesses warrant that cannot be defeated by any improvement of our information. While initially promising, the superassertability theory of truth is vulnerable to a persistent difficulty highlighted by James Van Cleve (1996) and Terrence Horgan (1995) but not properly fleshed out: it is formally illegitimate in a similar sense that unsophisticated epistemic (...) theories of truth are widely acknowledged to be. Sustained analysis reveals that the unrestricted formal legitimacy argument is firmly grounded in first person conceivability evidence. (shrink)

At Kyoto, there is something peculiar going on with negations, or so it seems: A is A, and yet A is immediately not A, and therefore A is A. Without a doubt, this looks a lot like a paradoxical inf...

The function of groups as information processors is increasingly being recognised in a number of theories of group cognition. A theme of many of these is an emphasis on sharing cognition. This paper extends current conceptualisations of groups by critiquing the focus on shared cognition and emphasising the distribution of cognition in groups. In particular, it develops an account of the distribution of one cognitive construct, mental models. Mental models have been chosen as a focus because they are used in (...) a number of theories of high level cognition from different areas of research such as cognitive science and human factors and so the implication of this development is wide reaching. This paper reviews the unconnected literatures on distributed cognition and mental models and integrates them in order to extend the theory of mental models to distributed cognitive systems such as groups. The distributed cognition literature is reviewed and the importance of considering the group as single cognitive system is adopted. A range of mental model theories are reviewed leading to the conclusion that they all have, in some form, the central feature of a mapping onto the cognitive system. Combining these two ideas, it is proposed that the model can be a mapping onto the whole group, if the information is distributed appropriately and the connections between parts of the model maintained through communication. This cognitive construct is referred to as a distributed mental model. Implications and applications of this theory are discussed. (shrink)

The aim of this study was to understand the relationship between bright-side, High Potential and dark-side Dark Triad traits, as well as work engagement on judgements of perceived success. In all, 290 working adults completed questionnaires assessing their High Potential Personality Traits, their dark-triad traits, job engagement and self-rated success at work. The data showed that the three dark-triad traits were systematically and significantly correlated with High Potential traits Adjustment/neuroticism, Tolerance of Ambiguity and Conscientiousness. Three HPTI traits, namely curiosity, Conscientiousness, (...) and courage, were systematically positively correlated with all three engagement measures. Narcissism was strongly related to all measures of engagement. Those with higher scores Adjustment, Courage, and Narcissism and of the male sex, rated their success highest. Job engagement mediated between high-flier and dark-side traits and success ratings. Implications and limitations are discussed. (shrink)

Este artículo estudia la estructura lógico-matemática ligada a la mereo-topología de la teoría de conjuntos (MTTC), en cuanto esta estructura es el núcleo gnoseológico del neoliberalismo. En este contexto, analizamos los componentes lógico-matemáticos de tal estructura, a saber, la mereología, la topología y la teoría de conjuntos en oposición a la noción dialéctica de totalidad, como un medio para superar las consecuencias políticas y gnoseológicas derivadas de la asunción de tal aparato lógico-matemático. Asimismo, establecemos una relación entre la MTTC y (...) la fenomenología, lo cual permite analizar algunas inconsistencias relacionadas no solo con la estructura lógico-matemática de la MTTC, sino también con la implementación de la intencionalidad fenomenológica y la subsecuente ley eidética de dependencia. (shrink)

Kant, in his third Critique, confronts the issue of how rule-governed objective judgement is possible. He argues that it requires a particular kind of aesthetic response to one's experience. I dub this response 'the Feeling of Unity', and I raise the question whether it is a type of inexpressible knowledge. Using David Bell's account of these matters as a touchstone, I argue that it is.

An anti-skeptical transcendental argument can be loosely defined as an argument that purports to show that some experience or knowledge of an external world is a necessary condition of our possession of some knowledge, concept, or cognitive ability that we know we have. In this dissertation I examine transcendental arguments by focusing on one such argument given by Immanuel Kant in his Critique of Pure Reason, along with some attempts to interpret that argument by contemporary commentators. ;I proceed by dividing (...) anti-skeptical transcendental arguments into three types: epistemological, verificationist, and psychological. I examine arguments of the first two types and show why they cannot succeed against the skeptic. I then argue that Kant's Refutation of Idealism is of a different type: it is psychological in that it concerns the necessary conditions of our forming beliefs of certain kinds. Many contemporary Kant scholars have claimed that his anti-skeptical strategy relies on phenomenalism or verificationism; I argue, however, that Kant in the Refutation employs a clever and hitherto unappreciated strategy which involves an empiricist principle concerning the origin of simple ideas, and which does not require either phenomenalism or verificationism. I conclude with an analysis and assessment of Kant's argument. (shrink)

The rural/metropolitan/wilderness hybrid central to urban shrinkage directly challenges a commonly held belief that a city consists of a dense concentration of people living in a limited geographical area, one where the primary means of production is non-agricultural. In addition, the urban condition of shrinkage tests the dominant current of growth management that has guided urban design, development, and land use. In this essay we will explore how this hybrid presents an alternative to the production and realization of surplus value (...) that predominates throughout the contemporary landscape of neoliberal planetary urbanization. It will be argued that this process of urbanization is premised upon modalities of urban commoning, or practices that bring a variety of social and environmental struggles into relationship with each other, dismantling the apparatuses of capture that bring land-use and the collective energies animating available land under the control of capital. (shrink)

La crisis sanitaria por coronavirus ha traído consigo una atención inusitada por las respuestas filosóficas. Son destacables aquellas que conceden un valor negativo a la esperanza, como una disposición evitable a toda costa. Paradójicamente, existe un intenso debate y un alto ritmo de publicaciones sobre el concepto de esperanza y sus beneficios para la vida humana. Mi objetivo consiste en ofrecer un balance de las principales contribuciones de los últimos veinte años, con especial atención a la llamada “descripción estándar” y (...) sus bases tomistas. Tras ello ofrezco tres conclusiones en torno a las bondades de la esperanza. (shrink)

Despite Jacques Lacan's somewhat deserved reputation as an adamant antinaturalist, his teachings, when read carefully to the letter, should not be construed as categorically hostile to any and every possible interfacing of psychoanalysis and biology. In recent years, several authors, including myself, have begun exploring the implications of reinterpreting Lacan's corpus on the basis of questions concerning naturalism, materialism, realism, and the position of analysis with respect to the sciences of today. Herein, I focus primarily on the efforts of analyst (...) François Ansermet and neuroscientist Pierre Magistretti to forge a specifically Lacanian variant of neuropsychoanalysis (as distinct from Anglo-American variants). Taking up Ansermet and Magistretti's interlinked theories of drive (Trieb) and autonomous subjectivity, I develop an immanent critique of their project. Doing so in a manner that is intended to acknowledge and preserve this neuropsychoanalytic duo's significant insights and contributions, I seek to bring into sharper relief the exact set of necessary, as well as sufficient, conditions for what Ansermet, Magistretti, and I all are commonly pursuing: an account of the genesis of denaturalized subjects out of embodied libidinal economies, itself situated within the framework of a nonreductive, quasi-naturalist materialism synthesizing resources drawn from psychoanalysis, neurobiology, and philosophy. (shrink)

Rapid technological advances have produced a variety of novel techniques that allow a comprehensive assessment of brain function to be combined with detailed information about brain structure and connectivity. Any assessment that is based on exhibited behavior after brain injury will be prone to error for a number of reasons. These questions are explored in the context of recent studies in both healthy populations and brain injured patients that have sought to investigate covert awareness through the use of functional neuroimaging. (...) Those circumstances in which functional magnetic resonance imaging data can be used to infer awareness in the absence of a behavioral response are contrasted with those circumstances in which it cannot. This distinction is fundamental for understanding and interpreting patterns of brain activity following acute brain injury and has implications for clinical care, diagnosis, prognosis, and medicolegal decision-making after serious brain injury. (shrink)

The proliferation of mitochondrial DNA (mtDNA) with deletion mutations has been linked to aging and age related neurodegenerative conditions. In this study we model the effect of mtDNA half-life on mtDNA competition and selection. It has been proposed that mutation deletions (mtDNAdel\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\text {mtDNA}_{del}$$\end{document}) have a replicative advantage over wild-type (mtDNAwild\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\text {mtDNA}_{wild}$$\end{document}) and that this is detrimental to the host cell, especially in post-mitotic (...) cells. An individual cell can be viewed as forming a closed ecosystem containing a large population of independently replicating mtDNA. Within this enclosed environment a selfishly replicating mtDNAdel\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\text {mtDNA}_{del}$$\end{document} would compete with the mtDNAwild\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\text {mtDNA}_{wild}$$\end{document} for space and resources to the detriment of the host cell. In this paper, we use a computer simulation to model cell survival in an environment where mtDNAwild\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\text {mtDNA}_{wild}$$\end{document} compete with mtDNAdel\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\text {mtDNA}_{del}$$\end{document} such that the cell expires upon mtDNAwild\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\text {mtDNA}_{wild}$$\end{document} extinction. We focus on the survival time for long lived post-mitotic cells, such as neurons. We confirm previous observations that mtDNAdel\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\text {mtDNA}_{del}$$\end{document} do have a replicative advantage over mtDNAwild\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\text {mtDNA}_{wild}$$\end{document}. As expected, cell survival times diminished with increased mutation probabilities, however, the relationship between survival time and mutation rate was non-linear, that is, a ten-fold increase in mutation probability only halved the survival time. The results of our model also showed that a modest increase in half-life had a profound affect on extending cell survival time, thereby, mitigating the replicative advantage of mtDNAdel\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\text {mtDNA}_{del}$$\end{document}. Given the relevance of mitochondrial dysfunction to various neurodegenerative conditions, we propose that therapies to increase mtDNA half-life could significantly delay their onset. (shrink)

The American Journal of Bioethics, Volume 12, Issue 9, Page 57-59, September 2012.

What are the leading forces and ideas that are shaping our age? In the West, a decade of financial disruption, austerity, and stagnant wages has produced a popular rejection of market fundamentalism that prevailed for over forty years. Mass immigration and multiculturalism have contributed to rapid changes in both family and community life that leave many people feeling dispossessed or even humiliated. Unresponsive government is exacerbating people’s sense of powerlessness and anger. The revolt against the status quo is fuelling a (...) political insurgency against the establishment that replaces the old opposition of left versus right with a similarly simplistic dichotomy pitting the people against the elites. We are witnessing the failure of dualistic thinking and this will not be resolved by substituting one binary for another. Our contemporary conjuncture is such a period of interregnum and a war of position between the hitherto hegemonic ideology of liberalism and its populist rivals. The popular revolt against liberalism, which is driving the political insurgency across the West, highlights the collapse of the authority of the professional political class dominated by liberals. In what follows I shall argue that the emergent ideologies which are vying for hegemony are hyper-liberalism, nationalist traditionalism, and tech utopianism. All of them are variously anti-humanist, to which one can oppose updated versions of one-nation conservatism and ethical socialism. Before setting out the unfolding ‘war of position,’ I will first explore the new anti-humanism that underpins the main ideological movements. (shrink)

This essay argues that modern sovereignty is not simply a legal or political concept that is coterminous with the modern nation-state. Rather, at the theoretical level modern sovereign power is inscribed into a wider theological dialectic between “the one” and “the many”. Modernity fuses juridical-constitutional models of supreme state authority with a new, “biopolitical” account of power whereby natural life and the living body of the individual are the object of politics and are subject to state control (section 1). The (...) origins of this dialectic go back to changes within Christian theology in the late Middle Ages and the early modern period. In particular, these changes can be traced to Ockham's denial of the universal Good in things, Suárez's priority of the political community over the ecclesial body and Hobbes's “biopolitical” definition of power as state dominion over life (section 2). At the practical level, modern sovereignty has involved both the national state and the transnational market. The “revolutions in sovereignty” that gave rise to the modern state and the modern market were to some considerable extent shaped by theological concepts and changes in religious institutions and practices: first, the supremacy of the modern national state over the transnational papacy and national churches; second, the increasing priority of individuality over collectivity; third, a growing focus on contractual proprietary relations at the expense of covenantal ties and communal bonds (section 3). By subjecting both people and property to uniform standards of formal natural rights and abstract monetary value, financial capitalism and liberal secular democracy are part of the “biopolitical” logic that subordinates the sanctity of life and land to the secular sacrality of the state and the market. In Pope Benedict's theology, we can find the contours of a post-secular political economy that challenges the monopoly of modern sovereignty (sections 4–5). (shrink)