Abstractβ1,4‐galactosyltransferase is unusual among the glycosyltransferases in that it is found in two subcellular compartments where it performs two distinct functions. In the trans‐Golgi complex, galactosyltransferase participates in oligosaccharide biosynthesis, as do the other glycosyltransferases. On the cell surface, however, galactosyltransferase associates with the cytoskeleton and functions as a receptor for extracellular oligosaccharide ligands. Although we now know much regarding galactosyltransferase function in these two compartments, little is known about how it is targeted to these different sites. By cloning the (...) galactosyltransferase gene products, certain features of the protein have been identified that may be critical for its expression on the cell surface or retention within the Golgi complex. This article discusses recent studies which suggest that a cytoplasmic sequence unique to one galactosyltransferase isoform is required for targeting a portion of this protein to the plasma membrane, enabling it to function as a cell adhesion molecule. These findings allow one to manipulate surface galactosyltransferase expression, either positively or negatively, and perturb galactosyltransferase‐dependent cellular interactions during fertilization and development. (shrink)

This study aimed to explore the understanding of and attitudes towards academic ethics of first-year students at a South African University using a paper-based survey that yielded 3611 respondents. A degree of confusion and ambivalence regarding academic ethical issues exists. The relative wealth of respondents also appears to influence the understanding of and attitudes to academic ethics. Millennial students have a tendency to disregard ownership of knowledge. There is a need for instruction in academic ethics to instil an awareness of (...) integrity in academic pursuit, coupled with an understanding of the world views of millennials. (shrink)

A new theoretical approach to language has emerged in the past 10–15 years that allows linguistic observations about form–meaning pairings, known as ‘construc- tions’, to be stated directly. Constructionist approaches aim to account for the full range of facts about language, without assuming that a particular subset of the data is part of a privileged ‘core’. Researchers in this field argue that unusual constructions shed light on more general issues, and can illuminate what is required for a complete account of (...) language. (shrink)

Cognitive science is, more than anything else, a pursuit of cognitive mechanisms. To make headway towards a mechanistic account of any particular cognitive phenomenon, a researcher must choose among the many architectures available to guide and constrain the account. It is thus fitting that this volume on contemporary debates in cognitive science includes two issues of architecture, each articulated in the 1980s but still unresolved: " • Just how modular is the mind? – a debate initially pitting encapsulated mechanisms against (...) highly interactive ones. • Does the mind process language-like representations according to formal rules? – a debate initially pitting symbolic architectures against less language-like architectures. " Our project here is to consider the second issue within the broader context of where cognitive science has been and where it is headed. The notion that cognition in general—not just language processing—involves rules operating on language-like representations actually predates cognitive science. In traditional philosophy of mind, mental life is construed as involving propositional attitudes—that is, such attitudes towards propositions as believing, fearing, and desiring that they be true—and logical inferences from them. On this view, if a person desires that a proposition be true and believes that if she performs a certain action it will become true, she will make the inference and perform the action. (shrink)

Sguardo d'insieme -- Armonia delle sfere celesti : Hildegard von Bingen, symphonia -- Il tempo di Dio : Johann Sebastian Bach, Cantata Gottes Zeit -- Trasmutazioni : Wolfgang Amadeus Mozart, Die Zauberflöte -- "Questo bacio vada al mondo intero" : Ludwig van Beethoven, An die Freude -- Viaggio d'inverno : Franz Schubert, Winterreise -- Inni all notte : Richard Wagner, Tristan und Isolde -- L'ultimo rito : Richard Wagner, Parsifal -- Azzurre solitudini : Gustav Mahler, Terza sinfonia -- Universi sonori (...) : Gustav Mahler, Ottava sinfonia -- Orizzonti perduti : Gustav Mahler, Das Lied von der Erde -- Labirinti : Richard Strauss, Also sprach Zarathustra -- Cortei di ombre : Richard Strauss, Metamorphosen -- La terza via : Omaggio a Francesco d'Avalos. (shrink)

Prolongement d’une séquence de cours donnée au sein du lycée suisse, cet article explore les liens entre philosophie et cinéma dans le cadre de l’enseignement d’une pratique de la philosophie. Confrontés à deux approches différenciées d’un même thème, celui du féminisme, les élèves sont encouragés à les mettre à l’épreuve d’un objet culturel, ici le film. En confrontant des extraits de Trouble dans le genre de Judith Butler et d’ Une voix différente de Carol Gilligan à des scènes tirées de (...) The Hours (Stephen Daldry, 2001), il apparaît que faire de la philosophie ne se réduit pas, pour les élèves, à répéter les idées développées par d’autres. Pas plus qu’enseigner la philosophie ne se réduit, pour les enseignants, à expliquer des textes sélectionnés par d’autres. La pratique de la philosophie s’apparente plutôt à une réappropriation du geste philosophique d’un auteur, de sa manière de faire, afin de l’utiliser face à d’autres textes, d’autres contextes culturels. (shrink)

In this paper I discuss the four Women and Labour conferences which were held in Australian capital cities over the seven years between 1978 and 1984. I explore the ways in which the history of Australian feminist activism during this period could be written, questioning in particular the claim that the Women and Labour conferences have been central to the history of Australian feminism. I discuss the ways in which a historical sense could be established, using writings about the conferences (...) as historical ‘evidence’, that race and ethnic divisions between women had not been important to the ‘women's movement’ until 1984. In other words, I challenge the construction of this conference as a turning point – not only in the feminist politicization of immigrant and Aboriginal women, but also in the politicization of all feminists about race and ethnic divisions. More broadly, I am interested in how a history would be written if it aimed to get to the ‘truth’ about racism and about the feminist activism of immigrant women. How would the apparent lack of written ‘evidence’ – at least until 1984 – of immigrant women's feminist activism, and of the awareness of Australian feminists about issues of racism, be written into this history? In addition, I suggest that it is important to the writing of feminist history in Australia that published documentation has been mostly produced by anglo women, and is thus partial and mediated by the lived, embodied experiences of anglo women. Finally, my intention is to interrogate commonly understood narratives about Australian feminist history, to challenge their seamlessness, and to suggest the importance of recognizing the tension within feminist discourses between difference as benign diversity and difference as disruption. (shrink)

We contend that diagrams are tools not only for communication but also for supporting the reasoning of biologists. In the mechanistic research that is characteristic of biology, diagrams delineate the phenomenon to be explained, display explanatory relations, and show the organized parts and operations of the mechanism proposed as responsible for the phenomenon. Both phenomenon diagrams and explanatory relations diagrams, employing graphs or other formats, facilitate applying visual processing to the detection of relevant patterns. Mechanism diagrams guide reasoning about how (...) the parts and operations work together to produce the phenomenon and what experiments need to be done to improve on the existing account. We examine how these functions are served by diagrams in circadian rhythm research. (shrink)

The idea that correspondences relating grammatical relations and semantics (argument structure constructions) are needed to account for simple sentence types is reviewed, clarified, updated and compared with two lexicalist alternatives. Traditional lexical rules take one verb as ‘input’ and create (or relate) a different verb as ‘output’. More recently, invisible derivational verb templates have been proposed, which treat argument structure patterns as zero derivational affixes that combine with a root verb to yield a new verb. While the derivational template perspective (...) can address several problems that arise for traditional lexical rules, it still faces problems in accounting for idioms, which often contain specifications that are not appropriately assigned to individual verbs or derivational affixes (regarding adjuncts, modification, and inflection). At the same time, it is clear that verbs play a central role in determining their distribution. The balance between verbs and phrasal argument structure constructions is addressed via the Principles of Semantic Coherence and Correspondence together with a usage-based hierarchy of constructions that contains entries which can include particular verbs and other lexical material. (shrink)

The present paper argues that there is ample corpus evidence of statistical preemption for learners to make use of. In the case of argument structure constructions, a verbi is preempted from appearing in a construction A, CxA, if and only if the following probability is high: P(CxB|context that would be suitable for CxA and verbi). For example, the probability of hearing a preemptive construction, given a context that would otherwise be well-suited for the ditransitive is high for verbs like explain (...) that overwhelmingly appear in the dative, and low for verbs like tell that readily appear in the ditransitive. Strength of statistical preemption is determined both by this probability, and by the frequency (ln (F)) of a verb in a preemptive construction when the context is at least as well suited to the preempted construction. The critiques of preemption by Stefanowitsch (Cognitive Linguistics 19: 513–531, 2008, this volume) are countered by arguing that the relevant probabilities were not considered. Moreover, we find evidence that constructions are somewhat less constrained when yoked to non-alternating verbs, as Stefanowitsch (cf. this volume) suggests should be the case. (shrink)

Wikipedia is known as a free online encyclopedia. Wikipedia uses largely transparent writing and editing processes, which aim at providing the user with quality information through a democratic collaborative system. However, one aspect of these processes is not transparent—the identity of contributors, editors, and administrators. We argue that this particular lack of transparency jeopardizes the validity of the information being produced by Wikipedia. We analyze the social and ethical consequences of this lack of transparency in Wikipedia for all users, but (...) especially students; we assess the corporate social performance issues involved, and we propose courses of action to compensate for the potential problems. We show that Wikipedia has the appearance, but not the reality, of responsible, transparent information production. (shrink)

In two experiments, participants had to choose between a sure and a risky option. The sure option was presented either in a gain or a loss frame. Need was defined as a minimum score the participants had to reach. Moreover, choices were made under two different time constraints and with three different levels of induced need to be reached within a fixed number of trials. The two experiments differed with respect to the specific amounts to win and the need levels. (...) The $$2 \times 2 \times 3$$2×2×3 design was a within-subject design. Data were evaluated on an overall and on a group level, the latter based on participants’ stated risk preference and on revealed preferences using cluster analysis across subjects. Overall, the results showed riskier behavior when the choice options were presented as losses as compared to gains and when the induced need was highest. Time limits enhanced the framing effect. (shrink)

Este artigo tem como objetivo apresentar como se estabelecem os estudos do filósofo húngaro Georg Lukács sobre a origem do complexo da arte a partir das formas abstratas do reflexo estético da realidade, a saber: ritmo, simetria e proporção e ornamentística. Tais categorias configuram-se, conforme os estudos de Lukács, em princípios; em elementos estruturais da produção artística, os quais são diversos, orientados por funções as mais variadas e já bastante evoluídas e que, de forma excepcional, no caso da ornamentística, mantiveram (...) sua independência, ainda que não tenham garantido o mesmo grau de importância de tempos remotos. Trata-se de um estudo teórico-bibliográfico, apoiado em uma base onto-histórica. O filósofo húngaro considera a dificuldade de revelar a procedência do complexo da arte. Atentamos ao método, considerando que devemos partir do já esteticamente formado, procedendo a tempos remotos, numa relação dialética. Podemos então nos aproximar da origem quando entendemos o mais desenvolvido. Nossas considerações vão ao encontro da compreensão de que qualquer nível de atividade humana deve implicar o trabalho como categoria fundante, na relação de transformação da natureza e do próprio homem. A arte, portanto, tem sua gênese no trabalho e, enquanto complexo tardio no mundo dos homens, tem o seu desprendimento do solo cotidiano, alcançando um processo de autoconsciência humana. Nesse sentido, a relevância do estudo consiste em contribuir com o projeto coletivo para o entendimento do papel da atividade criadora-receptora no aprimoramento dos sentidos, abrindo possibilidades de elevadas expressões no processo de humanização, com vistas à superação da sociabilidade regida pelo capital. (shrink)

The completion of the Human Genome Project has opened up unprecedented possibilities in healthcare, but also ethical and social dilemmas in terms of how these can be achieved. Genomic information can be seen as a "global public good" (GPG), in that it is represented by knowledge in the public domain and across national boundaries. Lack of investment, infrastructure and expertise in developing countries means that they are unable to take advantage of these GPG characteristics to address their health needs, fuelling (...) fears of a growing "genomics divide". Some have suggested an international knowledge sharing and capacity building network, a Global Genomics Initiative, as a means to harness the potential of genomics to reduce inequalities in health between North and South. Three UNESCO declarations also call for cooperation between developed and developing countries in genomics research and science and technology in general. Using international relations theories around global governance and networks as a conceptual framework, this paper examines whether these initiatives are likely to succeed in providing effective governance of genomics. (shrink)

This book examines Latina/o college student leadership and leadership development in higher education. Lozano analyzes emerging frameworks, empirical research, leadership models, essays, and promising practices to provide insight into how Latina/o students experience and promote leadership in higher education.

We contrast reactive and endogenously active perspectives on brain activity. Both have been pursued continuously in neurophysiology laboratories since the early 20thcentury, but the endogenous perspective has received relatively little attention until recently. One of the many successes of the reactive perspective was the identification, in the second half of the 20th century, of the distinctive contributions of different brain regions involved in visual processing. The recent prominence of the endogenous perspective is due to new findings of ongoing oscillatory activity (...) in the brain at a wide range of time scales, exploiting such techniques as single-cell recording, EEG, and fMRI. We recount some of the evidence pointing to ways in which this endogenous activity is relevant to cognition and behavior. Our major objective is to consider certain implications of the contrast between the reactive and endogenous perspectives. In particular, we relate these perspectives to two different characterizations of explanation in the new mechanistic philosophy of science. In a basic mechanistic explanation, the operations of a mechanism are characterized qualitatively and as functioning sequentially until a terminating condition is realized. In contrast, a dynamic mechanistic explanation allows for non-sequential organization and emphasizes quantitative modeling of the mechanisms's behavior. For example, with appropriate parameter values a set of differential equations can be used to demonstrate ongoing oscillations in a system organized with feedback loops. We conclude that the basic conception of mechanistic explanation is adequate for reactive accounts of brain activity, but dynamical accounts are required to explain sustained, endogenous activity. (shrink)

This paper focuses attention on the stakeholder attribute of legitimacy. Drawing upon institutional and stakeholder theories, I develop a framework of stakeholder legitimacy based on its three aspects—legitimacy of the stakeholder as an entity, legitimacy of the stakeholder’s claim, and legitimacy of the stakeholder’s behavior. I assume that stakeholder legitimacy is socially constructed by management and that each of its three aspects exists in degree in the manager’s perception. I discuss how these aspects interact and change over time, and propose (...) an agenda for future research on stakeholder legitimacy. (shrink)

Explanations in the life sciences frequently involve presenting a model of the mechanism taken to be responsible for a given phenomenon. Such explanations depart in numerous ways from nomological explanations commonly presented in philosophy of science. This paper focuses on three sorts of differences. First, scientists who develop mechanistic explanations are not limited to linguistic representations and logical inference; they frequently employ diagrams to characterize mechanisms and simulations to reason about them. Thus, the epistemic resources for presenting mechanistic explanations are (...) considerably richer than those suggested by a nomological framework. Second, the fact that mechanisms involve organized systems of component parts and operations provides direction to both the discovery and testing of mechanistic explanations. Finally, models of mechanisms are developed for specific exemplars and are not represented in terms of universally quantified statements. Generalization involves investigating both the similarity of new exemplars to those already studied and the variations between them. (shrink)

The Enneagram opens a remarkable window into the truth about us, but simply diagnosing our number doesn't do justice to who we are. Transformation happens as we grow in awareness and learn how to apply Enneagram insights to the rhythms of our daily lives. Filled with exercises to engage, challenge, encourage, and sustain, this handbook will help us grow in greater awareness and lead us to spiritual and relational transformation.

The aim of this essay is to approach the long literary tradition of catastrophic or apocalyptic narratives in relation to natural disasters and to explore examples of ecological threats to human species in contemporary Anglophone literature. By using the concept of ecophobia – a widespread irrational fear for nature – the author analyses novels by George R. Stewart ( Storm and Earth Abides ) and by Margaret Atwood ( Oryx and Crake ). Among the shared traits of these novels, the (...) author highlights the uncertain relationship with supernatural entities or divinities, the presence of surviving characters acting like last men of a disappearing human civilization, and the role of the humanities in the survival of the human species. (shrink)

Provides an account of how necessary subjective syntactic investments on the part of speakers affect the semantic contents of their words and the possibilities for their thought-contents.

Thelen et al. 's model of A-not-B performance is based on behavioral observations obtained with a paradigm markedly different from A-not-B. Central components of the model are not central to A-not-B performance. All data presented fit a simpler model, which specifies that the key abilities for success on A-not-B are working memory and inhibition. Intention and action can be dissociated in infants and adults.