The right to health is enshrined in the constitution of the World Health Organization and numerous other international agreements. Yet today, an estimated 5.7 million people die each year from treatable infectious diseases, most of which are susceptible to existing antimicrobials if they were accessible. These deaths occur predominantly among populations living in poverty in low- and middle-income countries, and they greatly exceed the estimated 700,000 annual deaths worldwide currently attributed to antimicrobial resistance. Ensuring universal appropriate access to antimicrobials is (...) not only a critical part of realizing the right to health, it is necessary for mobilizing effective collective action against the development and spread of AMR. (shrink)

Introduction: The Winding Road to Quantum Gravity Abhay Ashtekar Traveler, there are no paths; Paths are made by walking. ...

Logarithmic ambiguities in the choice of asymptotically Cartesian coordinates at spatial infinity are discussed. It is shown that they do not affect the definitions of energy-momentum and angular momentum at i°. Thus, from a physical viewpoint, the ambiguities are “pure gauge.” A prescription is given for fixed this gauge freedom for the class of space-times in which the leading-order part of the Weyl tensor satisfies a certain reflection symmetry. This class admits, in all (relatively boosted) rest frames at infinity, a (...) one-parameter family of asymptotically distinct 3-surfaces (generalized 3-planes) on which the trace of the extrinsic curvature falls off faster than usual. (shrink)

La philosophie du langage de Humboldt s'inscrit dans le courant de la philosophie de Kant. Aucun domaine de la linguistique ne lui demeura étranger : apprentissage des langues, types d'écriture (écriture chinoise), évolution des langues, communication. Il est le précurseur de Cassirer, auteur de la Philosophie des Formes symboliques, qui lui rendit hommage. La modernité de la philosophie de Humboldt fait de lui un précurseur de la "théorie de la complexité", tendance innovante de la pensée contemporaine illustrée par les travaux (...) d'Edgar Morin. (shrink)

When the Japanese invaded Joseon at the end of the sixteenth century, a Spanish Jesuit priest, Gregorio de Céspedes, S.J. , stayed in the Japanese fortress in Ungcheon with Japanese soldiers. While Céspedes is celebrated as the first European who allegedly came with an evangelical vision of proselytizing the native Koreans, previous scholarship has inadequately acknowledged Céspedes’ role without consideration of his concrete actions in the Japanese fortress and of the broader context of sixteenth–century Spanish colonial expansion. An examination of (...) the Jesuit mission to sixteenth-century Japan, the role of the Spanish chaplains and their activities in foreign expeditions, and Céspedes’ activities in Joseon indicate that Céspedes was not a missionary sent to Korea, but rather an active chaplain who played a role in the larger development of church and state collaboration under Spanish colonialism. (shrink)

In recent years Vietnam has experienced a high sex ratio at birth SRB) amidst rapid socioeconomic and demographic changes. However, little is known about the differentials in SRB between maternal socioeconomic and demographic groups. The paper uses data from the annual Population Change Survey (PCS) in 2006 to examine the relationship of the sex ratio of the most recent birth with maternal socioeconomic and demographic characteristics and the number of previous female births. The SRB of Vietnam was significantly high at (...) 111.4 (95% CI 109.7–113.1) for the period 1st April 2000 to 31st March 2006. Multivariate analysis reveals that sex of the most recent birth is strongly related with the number of previous female births. This association is consistent across different socioeconomic and demographic groups of women. Given the high SRB in Vietnam, further research into the reasons for high SRB in these groups is required, as are intervention programmes such as those raising the public awareness of its negative consequences. © Cambridge University Press, 2010. (shrink)

The process of antigenic variation in parasitic African trypanosomes is a remarkable mechanism for outwitting the immune system of the mammalian host, but it requires a delicate balancing act for the monoallelic expression, folding and transport of a single variant surface glycoprotein (VSG). Only one of hundreds of VSG genes is expressed at time, and this from just one of ≈15 dedicated expression sites. By switching expression of VSGs the parasite presents a continuously shifting antigenic facade leading to prolonged chronic (...) infections lasting months to years. The basics of VSG structure and switching have been known for several decades, but recent studies have brought higher resolution to many aspects this process. New VSG structures, in silico modeling of infections, studies of VSG codon usage, and experimental ablation of VSG expression provide insights that inform how this remarkable system may have evolved. (shrink)

This study examines the hypothesis that the stopping rule-a traditional postnatal sex selection method where couples decide to cease childbearing once they bear a son-plays a role in high sex ratio of last births (SRLB). The study develops a theoretical framework to demonstrate the operation of the stopping rule in a context of son preference. This framework was used to demonstrate the impact of the stopping rule on the SRLB in Vietnam, using data from the Population Change Survey 2006. The (...) SRLB of Vietnam was high at the level of 130 in the period 1970-2006, and particularly in the period 1986-1995, when sex-selective abortion was not available. Women were 21% more likely to stop childbearing after a male birth compared with a female birth. The SRLB was highest at parity 2 (138.7), particularly in rural areas (153.5), and extremely high (181.9) when the previous birth was female. Given the declining fertility, the stopping rule has a potential synergistic effect with sex-selective abortion to accentuate a trend of one-son families in the population. (shrink)

Human resource management in managing environmental, social, governance, or corporate social responsibility initiatives has been recently raised. Yet, little attention has been paid to integrating CSR and HRM. Our primary goal was to identify how and whether certain HR practices are critical for developing employee capability to operate in firms with active CSR initiatives. We first examine the impact of external CSR activities on firm-level work outcomes. Moreover, we attempt to identify a choice of particular HR practices that could be (...) aligned with external CSR activities. We then empirically examine how each HR practice interacts with external CSR activities that influence employee retention and labor productivity. Using three longitudinal datasets conducted by the government-sponsored research institution over 154 publicly traded Korean firms for five waves of survey years, the results show that external CSR has a limited impact on employee retention and labor productivity. However, when external CSR activities are combined with a specific set of HR practices, including person-organization fit-based selection, performance-based pay, extensive investment of training and development, and employee suggestion program, the impact of external CSR on employee work outcomes is more substantial. The results indicate that external CSR and a particular set of HR practices as internal CSR can be complementary and generate a positive interaction on creating sustainable human capabilities. (shrink)

Elementary Applied Symbolic Logic was first published by Prentice-Hall in 1976. It went through two editions with them, then had a successful classroom run of 25 years by various publishers, before it finally went out of print in 2001.I am reviving it here, because during its run it acquired a reputation as an outstanding textbook for getting students to understand symbolic logic.I immodestly believe it is the best textbook ever written on the subject.------------This is a book on applied symbolic logic. (...) It provides the bridge between statements and arguments in English, and their formal counterparts in symbolic logic. Extensive exercises are given, illustrating how different natural-language concepts can correspond to the same symbolism, and how English sentences may be translated into formulae. Translation is heavily emphasized.It is intended to make learning symbolic logic (relatively) easy, by starting out with very basics and progressing from there a step at a time, building on what came before. I tried to make it as close to a self-teaching text as I could manage. It has two major divisions: Propositional Logic and Quantifier Logic.The first starts with propositions and truth-values, then truth-tables for evaluating the status of statements and arguments. It then moves to natural deduction, with rules for making inferences and transformations. Procedures are given for proving both validity and invalidity.Exercises increase in complexity as things move along. Solutions to selected exercises are included at the back of the book.Quantifier Logic starts with Monadic predicate logic, involving only single-place predicates ("properties"). It starts with singular statements and propositional functions, then moves to statements containing a single universal or existential quantifier, then to statements and arguments involving multiple quantifiers. It covers inferences using quantificational inference and transformation rules, and gives methods of invalidity proof.Its second half goes into polyadic predicates ("relations") of various degrees, moves on to identity, and finally to definite descriptions.Appendices on various related and supplementary topics are included at the end. The original appendix on Completeness and Consistency was complicated and confusing. It has been deleted, and replaced with an addendum at the end. (shrink)

Tracing increasing distrust of politicians and democratic institutions back to the negative idea of political power and freedom as always being a 'power over' and 'freedom from', this text examines Foucault's alternative conception of the politician as one who has the courage to tell people the truth about what has to be done in the face of the dangers they confront. Telling the truth is not sufficient, but must be complemented with empowering people to actively help in overcoming the dangers (...) themselves. Breaking with conceptions of politics as hierarchy and anarchy, Foucault contended that where there is obedience, there cannot be truth and genuine freedom. This book offers a redefinition of power and freedom within a circular logic of true authority and self-governance. It argues that democracy cannot survive without being innovated along these lines, and considers what can be done to reconnect politicians and laypeople in order to rebuild their mutual trust in each other's political capacities. (shrink)

This book addresses nothingness as not only the untangible presence of an emotional, cultural, social, or even political void that is felt on an existential level, but has some solid foundations in reality. The death of a loved one, the social isolation of an individual, or the culture shock one may experience in another country are examples of situations in which an external sense of absence mirrors an internal psychological and philosophical sense of nothingness. Not much has been explicitly written (...) on nothingness in the history of psychology. On the other hand, nothingness seems to be implicitly embedded in many scholars' work. This duality of explicitly and implicitly expressed ideas about nothingness reveals how psychology finds inspiration in philosophy, and vice versa. The book aims to illustrate how the concept of the presence of absence--nothingness--fills a void in contemporary psychological theorizing. (shrink)

This paper explores the reception of Gellner’s historical sociology among students of pre-modern societies and the Greco-Roman world in particular and asks how his thought is still relevant to the field. This involves discussion of recent trends in world history as well as new comparative work on ancient state and elite formation. A main contention of the paper is that Gellner’s sociological reading of Plato and his politics may be one of the most interesting modern interpretations of the ancient Greek (...) thinker on offer and one which can serve as a fruitful framework for the comparative study of complex, pre-industrial societies. (shrink)

Levensbeschrijving van de Engelse politicus en humanist (1478-1535), auteur van 'Utopia' (1516) met een interpretatie van dat werk in de zestiende-eeuwse context.

For much of their history, the relationship between anthropology and psychology has been well captured by Robert Frost's poem, “Mending Wall,” which ends with the ironic line, “good fences make good neighbors.” The congenial fence was that anthropology studied what people think and psychology studied how people think. Recent research, however, shows that content and process cannot be neatly segregated, because cultural differences in what people think affect how people think. To achieve a deeper understanding of the relation between process (...) and content, research must integrate the methodological insights from both anthropology and psychology. We review previous research and describe new studies in the domain of folk biology which examine the cognitive consequences of different conceptualizations of nature and the place of humans within it. The focus is on cultural differences in framework theories among Native Americans and European American children and adults living in close proximity in rural Wisconsin. Our results show that epistemological orientations affect memory organization, ecological reasoning, and the perceived role of humans in nature. This research also demonstrates that cultural differences in framework theories have implications for understanding intergroup conflict over natural resources and are relevant to efforts to improve science learning, especially among Native American children. (shrink)

In a range of contexts, individuals arrive at collective decisions by sharing confidence in their judgements. This tendency to evaluate the reliability of information by the confidence with which it is expressed has been termed the ‘confidence heuristic’. We tested two ways of implementing the confidence heuristic in the context of a collective perceptual decision-making task: either directly, by opting for the judgement made with higher confidence, or indirectly, by opting for the faster judgement, exploiting an inverse correlation between confidence (...) and reaction time. We found that the success of these heuristics depends on how similar individuals are in terms of the reliability of their judgements and, more importantly, that for dissimilar individuals such heuristics are dramatically inferior to interaction. Interaction allows individuals to alleviate, but not fully resolve, differences in the reliability of their judgements. We discuss the implications of these findings for models of confidence and collective decision-making. (shrink)

ABSTRACTHow do different forms of education contribute to value preferences? Clearly, informal education through personal experiences that shape one’s sense of identity and frame cultural expectations and opportunities, non-formal education through religious traditions and formal state-mandated education all contribute to value preferences in culturally-specific ways. However, wisdom should allow people to coordinate culturally-specific education in ways that promote prosocial values. Our study considered the relative strength of four value-orientations from Schwartz’s Personal Values Questionnaire and of 15 core virtues among 189 (...) participants from Canada and South Korea; half were older and half younger adults. 101 were emerging adults and 88 were retired older adults. Multivariate regression analyses show that, although all three forms of education influenced value orientation in culture-specific ways in both Canada and South Korea, formal education was critical to cultivating the wisdom needed to coordinate and adjudicate between different values so as to live well. (shrink)

The relationship between workaholism and work performance is explored by meta-analysis in this article. After searching relevant references, we had gained 94 individual effect sizes, 45 individual samples, and 37 references. Through the heterogeneity test, it was shown that the random effect model is more suitable. The main effect analysis showed that there is a significant positive correlation between workaholism, working excessively, working compulsively, and work performance, and further analysis showed that workaholism emphasizes the improvement of contextual performance. The subgroup (...) test showed that the relationship between workaholism, working excessively, working compulsively, and work performance is influenced by the measurement tools of workaholism, but not influenced by the cultural background differences and time-lag research. The above results show that workaholism and its dimensions have different influences on different aspects of work performance. Besides, it is worthy to consider the moderating function of the measurement tools of workaholism in the relationship between workaholism and work performance. (shrink)

Research indicates that individuals have incoherent intuitions about particular features of the criminal justice system. This could be seen as an argument against the existence of adapted computational systems for counter-exploitation. Here, I outline how the model developed by McCullough et al. readily predicts the production of conflicting intuitions in the context of modern criminal justice issues.

보존이란 인간의 활동을 규제해서라도 야생자연이나 생물종을 있는 그대로 지켜야 한다는 사고다. 하지만 패스모어는 인간이 문명의 건설 · 발전을 위해 야생지를 개발하고 생물을 멸종시키는 현 상황이 대체 무슨 문제가 되는가 하는 물음을 제기한다. 야생지 개발과 생물종 파괴가 잘못이라는 판단에 대한 합의는 전혀 이뤄진 적이 없음에도 마치 일정한 합의가 이뤄진 것처럼 보존만이 옳은 것처럼 강조하는 이유가 대체 무엇인가 하는 것이다. 이러한 문제의식 하에 패스모어는 보존에 반대하는 논증을 전개한다. 이 글에서는 패스모어의 보존에 관한 논의 가운데 세 가지 사항을 문제삼아 그 정당성을 검토하고 있다. (...) 그 세 가지란 ①보전과 보존의 개념 문제, ②동식물의 권리 문제, 그리고 ③생물다양성의 원리 문제다. (shrink)

Metabolism is a set of chemical reactions, used by living organisms to process chemical compounds in order to take energy and eliminate toxic compounds, for example. Its processes are referred as metabolic pathways. Understanding metabolism is imperative to biology, toxicology and medicine, but the number and complexity of metabolic pathways makes this a difficult task. In our paper, we investigate the use of causal Bayesian networks to model the pathways of yeast saccharomyces cerevisiae metabolism: such a network can be used (...) to draw predictions about the levels of metabolites and enzymes in a particular specimen. We propose a two-stage methodology for causal networks, as follows. First construct a causal network from the network of metabolic pathways. The viability of this causal network depends on the validity of the causal Markov condition. If this condition fails, however, the principle of the common cause motivates the addition of a new causal arrow or a new `hidden' common cause to the network (stage 2 of the model formation process). Algorithms for adding arrows or hidden nodes have been developed separately in a number of papers, and in this paper we combine them, showing how the resulting procedure can be applied to the metabolic pathway problem. Our general approach was tested on neural cell morphology data and demonstrated noticeable improvements in both prediction and network accuracy. (shrink)