The translocation of tRNAs through the ribosome proceeds through numerous small steps in which tRNAs gradually shift their positions on the small and large ribosomal subunits. The most urgent questions are: (i) whether these intermediates are important; (ii) how the ribosomal translocase, the GTPase elongation factor G (EF‐G), promotes directed movement; and (iii) how the energy of GTP hydrolysis is coupled to movement. In the light of recent advances in biophysical and structural studies, we argue that intermediate states of translocation (...) are snapshots of dynamic fluctuations that guide the movement. In contrast to current models of stepwise translocation, kinetic evidence shows that the tRNAs move synchronously on the two ribosomal subunits in a rapid reaction orchestrated by EF‐G and GTP hydrolysis. EF‐G combines the energy regimes of a GTPase and a motor protein and facilitates tRNA movement by a combination of directed Brownian ratchet and power stroke mechanisms. (shrink)

The House Sparrow (Passer domesticus), formerly a common bird species, has shown a rapid decline in Western Europe over recent decades. In The Netherlands, its decline is apparent from 1990 onwards. Many causes for this decline have been suggested that all decrease the vital rates, i.e. survival and reproduction, but their actual impact remains unknown. Although the House Sparrow has been dominant in The Netherlands, data on life history characteristics for this bird species are scarce: data on reproduction are non-existent, (...) and here we first present survival estimates based on live encounters and dead recoveries of marked individuals over the period 1976–2003, 14 years before and 14 years during the decline, reported to the Dutch Ringing Centre. We show that there is an indication that both juvenile and adult survival are lower during the period of decline. -/- Secondly, to be able to analyse the relative impact of changes in the vital rates, we formulated a general matrix model based on a range of survival values between zero and one with a step size of 0.01 (both juvenile and adult yearly survival) and a range of realistic reproduction values (one, three or five fledglings per pair per year). With the matrix model, we calculated the finite rate of population change (λ) and applied elasticity analysis. To diagnose the cause of the decline in the Dutch House Sparrow, we parameterised the model with estimates of survival values before and during the decline and present the resulting λ. With the survival estimates from the declining period, λ < 1 only if reproduction is relatively low. We discuss this result within the light of available literature data on survival in the House Sparrow. Finally, we evaluate which of the suggested causes of population decline should be reversed to mitigate the decline and how this can be achieved. (shrink)

The House Sparrow (Passer domesticus), formerly a common bird species, has shown a rapid decline in Western Europe over recent decades. In The Netherlands, its decline is apparent from 1990 onwards. Many causes for this decline have been suggested that all decrease the vital rates, i.e. survival and reproduction, but their actual impact remains unknown. Although the House Sparrow has been dominant in The Netherlands, data on life history characteristics for this bird species are scarce: data on reproduction are non-existent, (...) and here we first present survival estimates based on live encounters and dead recoveries of marked individuals over the period 1976–2003, 14 years before and 14 years during the decline, reported to the Dutch Ringing Centre. We show that there is an indication that both juvenile and adult survival are lower during the period of decline. Secondly, to be able to analyse the relative impact of changes in the vital rates, we formulated a general matrix model based on a range of survival values between zero and one with a step size of 0.01 (both juvenile and adult yearly survival) and a range of realistic reproduction values (one, three or five fledglings per pair per year). With the matrix model, we calculated the finite rate of population change (λ) and applied elasticity analysis. To diagnose the cause of the decline in the Dutch House Sparrow, we parameterised the model with estimates of survival values before and during the decline and present the resulting λ. With the survival estimates from the declining period, λ < 1 only if reproduction is relatively low. We discuss this result within the light of available literature data on survival in the House Sparrow. Finally, we evaluate which of the suggested causes of population decline should be reversed to mitigate the decline and how this can be achieved. (shrink)

© 2016 Regents of the University of California.The Review summarizes much of particle physics and cosmology. Using data from previous editions, plus 3,062 new measurements from 721 papers, we list, evaluate, and average measured properties of gauge bosons and the recently discovered Higgs boson, leptons, quarks, mesons, and baryons. We summarize searches for hypothetical particles such as supersymmetric particles, heavy bosons, axions, dark photons, etc. All the particle properties and search limits are listed in Summary Tables. We also give numerous (...) tables, figures, formulae, and reviews of topics such as Higgs Boson Physics, Supersymmetry, Grand Unified Theories, Neutrino Mixing, Dark Energy, Dark Matter, Cosmology, Particle Detectors, Colliders, Probability and Statistics. Among the 117 reviews are many that are new or heavily revised, including those on Pentaquarks and Inflation. The complete Review is published online in a journal and on the website of the Particle Data Group. The printed PDG Book contains the Summary Tables and all review articles but no longer includes the detailed tables from the Particle Listings. A Booklet with the Summary Tables and abbreviated versions of some of the review articles is also available. (shrink)

ObjectiveStress can play a role in the onset and exacerbation of psoriasis. Psychological interventions to reduce stress have been shown to improve psychological and psoriasis-related outcomes. This pilot randomised study investigated the feasibility of a brief interaction with a Paro robot to reduce stress and improve skin parameters, after a stressor, in patients with psoriasis.MethodsAround 25 patients with psoriasis participated in a laboratory stress task, before being randomised to either interact with a Paro robot or sit quietly for 30 min. (...) Raman spectroscopy and trans-epidermal water loss were measured at baseline, after the stressor and after the intervention as indexes of acute skin changes. Psychological variables, including self-reported stress and affect, were also measured at the three time-points.ResultsNo statistically significant differences between the two conditions were found for any of the outcomes measured. However, effect sizes suggest significance could be possible with a larger sample size. Changes in the psychological and Raman spectroscopy outcomes across the experimental session were found, indicating the feasibility of the procedures.ConclusionThis pilot study showed that a brief interaction with a Paro robot was a feasible intervention for patients with psoriasis, but future trials should broaden the inclusion criteria to try to increase recruitment rates. Studying people who are highly stressed, depressed or who are stress-responders may increase the power of the intervention to show effects using a longer-term intervention. (shrink)

Tobacco consumption is believed to be one of the world’s greatest preventable health problems. According to the World Health Organisation, 1.1 billion people worldwide are addicted to nicotine with tobacco causing an estimated four million premature deaths every year. The development of a nicotine conjugate vaccine suggests that immunisation may hold promise as a future therapeutic and preventive strategy for tobacco smoking and nicotine addiction. Allowing parents to immunise their children against smoking could be an infringement of children’s right to (...) an open future, however, and is not ethically unproblematic. (shrink)

Desde la aparición, en 1927, de su obra central Ser y tiempo, Martin Heidegger ha sido y sigue siendo considerado por amplios sectores de opinión como el filósofo más importante del siglo XX. Frente a esta sobrevaloración del filósofo de los Bosques Negros, Heleno Saña procede, en su documentadísimo libro, a una crítica de la filosofía heideggeriana, intentando demostrar que está basada en una tergiversación e instrumentalización sistemáticas de la terminología y los conceptos esenciales de la filosofía clásica. El resultado (...) final de sus ejercicios hermenéuticos y sus continuos malabarismos lingüísticos, es un irracionalismo de índole claramente nihilista, por su culto implícito y explícito a la muerte. En este sentido es altamente significativo que a la biografía y a la filosofía heideggerianas pertenezcan su adhesión al nacionalsocialismo y la glorificación de Alemania como la “raza de los señores” por excelencia, tema al que Heleno Saña dedica la debida atención. Uno de los signos distintivos de este ensayo es el de la claridad con que expone sus tesis, de manera que el libro no está pensado solo para eruditos, sino para todas las personas interesadas en ampliar sus conocimientos culturales y filosóficos. (shrink)

I would like to begin with the role of philosophy in solving ecological problems, emphasizing two aspects of its role: the struggle against hostile ideology and the organizing and guiding of activity in the sphere of the development of science and the shaping of its problems. This role of Marxist-Leninist philosophy clearly appears in the complex interdisciplinary problem of the interaction between nature and society.

The article is devoted to the criticism of the revolutionary ideas of Karl Marx by the great political thinker of the 20 th century, Eric Voegelin (1901-1985). The article shows that Voegelin’s criticism of the Marxist doctrine consists of several successive stages. In his works of the late 1930s, he develops the idea of Marxism and communism, which grew up on its ideological basis, as one of the main “political religions” of the XX century. In the 1940s, when Voegelin was (...) living in exile in the United States, he continued to criticize the Marxism of Marx, but on a new theoretical basis, at the center of which was the concept of “gnosticism” as the essence of Western modernity. Since the 1950 s, Voegelin’s interest in the Marxism of Marx gradually faded away, and the Marxist doctrine itself is mostly mentioned as an example of one of the variants of “gnosticism” of the 20th-century politics. As a theoretical horizon of Voegelin’s criticism of the Marxian revolutionary idea, a brief reconstruction of the main propositions of his political theory as an experimental and critical science of the correct order of the soul and society is presented. Voegelin’s thesis that the rise of “gnosticism” is the essence of Western modernity is also analyzed in detail, since it serves as the central point of his interpretation of modern intellectual history. The article shows that the spiritual basis on which the development of the Marxian revolutionary idea took place was the revolt of the young Marx against God and his desire to eliminate the higher, transcendent and creative divine principle from the picture of the world of modern man. Voegelin's final conclusion, proposed by him in the framework of criticism of the Marxian revolutionary idea, is that the political success of Marxism in the XX century is one of the most significant symptoms of the spiritual decline of Western civilization. (shrink)

Now in its fifth edition, Good Reasoning Matters! is a practical guide to recognizing, evaluating, and constructing arguments. Combining straightforward instruction with abundant exercises and examples, this innovative introduction to argument schemes and rhetorical techniques will help students learn to think critically both within and beyond the classroom.

On fundamentals of Vedanta and science; a study.

A group of activist clinicians have offered to volunteer for clinical trials of live attenuated HIV vaccines. This has provided an important conceptual challenge to medical ethics, and to work on the development of HIV vaccines. In exploring these issues, this article highlights how the HIV field has altered the content as well as the tone of ethical discourse. The balance of expertise and authority between research subjects and triallists is profoundly changed, raising questions about the limits of voluntarism and (...) differing perspectives on risk-benefit analysis. Care is needed to ensure that the novelty of the situation does not confuse the central ethical and scientific issues. (shrink)

The analysis presented in this article shows that overarching conceptual systems, such as the metaphor “NATIONS ARE A FAMILY,” often bring together expressions with dissimilar intentions, ideologic...