Rho proteins belong to the small GTPases superfamily. They function as molecular switches that, in response to diverse stimuli, control key signaling and structural aspects of the cell. Although early studies proposed a role for Rho GTPases in cellular transformation, this effect was underestimated due to the fact that no genetic mutations affecting Rho‐encoding genes were found in tumors. Recently, it has become evident that Rho GTPases participate in the carcinogenic process by either overexpression of some of the members of (...) the family with oncogenic activity, downmodulation of other members with suggested tumor suppressor activity, or by alteration of upstream modulators or downstream effectors. Thus, alteration of the levels of expression of different members of the family of Rho GTPases has been detected in many types of human tumors leading to a great interest in the cellular effects elicited by these oncoproteins. This essay reviews the current evidence of dysregulation of Rho signaling by overexpression in human tumors. BioEssays 27:602–613, 2005. © 2005 Wiley Periodicals, Inc. (shrink)

¿Qué es una revolución? ¿Qué fuerzas la desencadenan? ¿Por qué fases atraviesa? ¿Es un acontecimiento imprevisible, que actúa al modo de una explosión volcánica, como pensaba Joseph de Maistre, o es un fenómeno enraizado en factores observables, acumulados a lo largo del tiempo, como afirmó Tocqueville? ¿Es el resultado necesario de factores estructurales, de acuerdo con procesos deterministas de carácter inevitable, como pensaba Karl Marx, o es algo contingente, provocado y dirigido por la acción consciente de grupos sociales con propósitos (...) definidos, como demostró Ted R. Gurr? Y, de ser así, ¿están enraizados tales factores y/o responden tales propósitos a aspiraciones predominantemente materiales y económicas, o son más bien de tipo espiritual, relacionados con la dignidad y el deseo de libertad de los participantes, o incluso con percepciones transcendentes, relacionadas con la seguridad ontológica y la percepción identitaria de las sociedades y los grupos participantes? ¿Qué resultados cabe esperar de las revoluciones y qué factores inciden sobre ellos? (shrink)

Music in Hegel's philosophical system.- Hegelian thought about music is part of a common idealist way of treating the arts: a metaphysical way, regarding art in its relation to truth. Thus it matches up to the way in which modern philosophy approaches aesthetics. Starting from a study of music we can make a new approach to the philosophy of Hegel, its problems, and its relation to the period of Romanticism in which it arose.

La existencia constituye un desafio para la relación entre pensamiento y realidad. Se aborda aquí esta problemática a partir de una aproximación entre Hegel y Tomás de Aquino, siendo que ambos sitúan la verdad en el ámbito de lo inteligible. Ahora bien, la realidad, al convocar la existencia, convoca también una reflexión sobre la inteligibilidad misma. Tomás encara la existencia como condición necesaria para la inteligibilidad; Hegel apela a la inteligibilidad como condición necesaria para la existencia. El talante metafísico de (...) esta discusión (diacrónica) alcanza su culminación en la cuestión sobre la existencia de Dios. (shrink)

Dans cet ouvrage, Herbert Spencer propose une exploration approfondie de la psychologie, explorant les principes fondamentaux qui sous-tendent notre perception et notre compréhension du monde qui nous entoure. Ce livre est un classique de la psychologie moderne et une lecture indispensable pour les étudiants et les professionnels. This work has been selected by scholars as being culturally important, and is part of the knowledge base of civilization as we know it. This work is in the "public domain in the United (...) States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant. (shrink)

The author demonstrates how the problem of free will as inherited by Descartes from scholastic philosophy is translated into secular terms. This monograph reviews some of the significant bibliography on the subject, particularly the studies of Octave, Hamelin, E. Gilson, A. Espinas, and H. Gouhier.--A. R.

In 1877, the young Alfred Espinas defended a philosophical study, ‘doctorat ès lettres’, at the Sorbonne University, entitled Des Sociétés animales. This was to become one of the principal sources of French organicist sociology. The paradox, however, is that this work seems to be fundamentally a study of natural science. Espinas tried to justify his position theoretically through two types of reciprocally exclusive and uncomplementary arguments. The first one consists in showing that only certain kinds of animal groupings belong legitimately, (...) if not academically, to sociology. The second one has a greater audacious and uncontrollable dimension. It consists in asserting that all pluricellular organisms are true societies. In this article we first focus on the role played by cellular theory in such a ‘sociologization’ of biology, concerning the extension of sociology. Second, we examine the importance of such confusion within the fields of extension, in aiming to explain the conceptual transfers between social sciences and life sciences, in the second half of the 19th century. (shrink)

Se estudian los orígenes de la radiodifusión en España con la creación de Radio Ibérica que comienza a emitir en 1924 y cesa su actividad en 1927 con su adquisición por su rival Unión Radio, que tras la guerra civil y hasta nuestros días pasaría a denominarse Sociedad Española de Radiodifusión (SER). La participación de las mujeres en las tareas de la radio se describe cronológicamente, comenzando con la labor de la escritora y periodista Teresa de Escoriaza y siguiendo con (...) locutoras como María Sabater, la técnica de sonido María Ángeles García, la actriz Carmen Seco, loas escritoras y periodistas Josefina Carabias, Matilde Muñoz, Concha Espina y Luisa Alberca. El trabajo finaliza con un resumen del inicio de la actividad de revistas consultorios femeninos con la participación de María del Patrocinio Alba, Mercedes Fortuna, Julita Calleja, Petrita Tamayo y Mercedes Lastra. (shrink)

The article traces Nietzsche’s references to insects in his published and unpublished writings against the backdrop of his study of the entomological research of his time (esp. through his reading of Alfred Espinas’s Die thierischen Gesellschaften). The first part of the article explores how Nietzsche’s entomology allows us to add a posthumanist perspective to the more familiar poststructuralist readings of Nietzsche, as the entomological research he consulted offered him a model for understanding how rudimentary processes can lead to the formation (...) of structures and higher organizations with emergent properties. The second part of the article revisits Nietzsche’s conceptions of the will and the will to power against the backdrop of his references to insect sociality and the influence of Wilhelm Wundt. It shows that Nietzsche’s deconstruction of the will as an umbrella concept and his will to power are attempts to model the emergence of complex edifices from simple operations under which physical, psychological, and social phenomena must be thought to arise. The article concludes with a reflection of the social and political relevance of what Nietzsche identifies as modernity’s “disgregation of the will.”. (shrink)