This paper examines the concept of ‘openness with patients’ from the stand-point of the limitations of biomedical ethics. Initially we review contemporary critiques of bioethics and, in particular, of principlism; we relate how other; somewhat neglected, forms of medical ethics can yield useful information and provide moral guidance. The main section of the paper then shows how a bioethical approach to openness misses the social context in our example, the viewpoints of patients; we present some of the increasing wealth of (...) research evidence which points towards patients wanting more information and a greater degree of openness. (shrink)

A motivational system approach to avoidance behavior is presented. According to this approach, a motivational state increases the probability of relevant response patterns and establishes the appropriate or “ideal” consummatory stimuli as positive reinforcers. In the case of feeding motivation, for example, hungry rats are likely to explore and gnaw, and to learn to persist in activities correlated with the reception of consummatory stimuli produced by ingestion of palatable substances. In the case of defense motivation, fearful rats are likely to (...) flee or freeze, and to learn to persist in activities correlated with consummatory stimuli produced by flight from a dangerous place. Defense system activation is distinct from alarm reactions. The latter prepare the animal for probable noxious events, involve relatively intense negative affect and extinguish rapidly in situations where the noxious event no longer occurs. In contrast, defense system activation potentiates innate and modified defense reactions, thus preparing the animal for possible, but not necessarily probable, noxious events; it involves little or no negative affect and extinguishes very slowly when the noxious event no longer occurs. With these assumptions and the resulting model we attempt to resolve several long-standing problems in avoidance learning, including the low correlation between negative affect and avoidance performance, differential rates of extinction for avoidance performance and conditioned emotional responses, and evidence that some avoidance responses are much more easily learned than others. In addition, the model has implications for the study of parallels between appetitive and aversive motivation, sign tracking in aversive conditioning, and orientation of flight responses. Historical antecedents and alternative approaches are discussed. (shrink)

Studies in Stoicism contains six unpublished and seven republished essays, the latter incorporating additions and changes which Brunt wished to be made. The papers have been integrated and arranged in chronological order by subject matter, with an accessible lecture to the Oxford Philological Society serving as Brunt's own introduction.

Why is female violence a taboo? We suggest that both men and women actively contribute to the creation of this stigma. Men may benefit because nonaggressive women may make better mothers and be more faithful and fertile. Females may benefit by downplaying their aggressive nature because they will be perceived as more valuable mates and because they will be more accepted within female social groups.

This paper examines the concept of ‘openness with patients’ from the stand-point of the limitations of biomedical ethics. Initially we review contemporary critiques of bioethics and, in particular, of principlism; we relate how other; somewhat neglected, forms of medical ethics can yield useful information and provide moral guidance.The main section of the paper then shows how a bioethical approach to openness misses the social context in our example, the viewpoints of patients; we present some of the increasing wealth of research (...) evidence which points towards patients wanting more information and a greater degree of openness.Finally we put forward that a principlist’s objection to active encouragement of openness might be based on the risk of infringing upon the ‘right not to know’. We reject this by arguing how rights can be trumped. (shrink)

There has been much discussion about what, if any, legal and moral duties professionals have to disclose relevant genetic information to the family members of someone with an identified disease predisposing mutation. Here, we present a case report where dissemination of such a genetic test result did not take place within a family. In contrast to previous literature, there appeared to be no deliberate withholding of information, instead distant relatives were unable to communicate relevant information appropriately. When communication was facilitated (...) through the follow-up of a chance remark, the patient was able to avoid planned major surgery, with its attendant morbidity, and her high anxiety levels were much reduced. We believe this case highlights the need for an ongoing debate on how genetic services can best support patients and their families with disclosing relevant genetic information to other family members. (shrink)

This paper examines the popular philosophical theory of moral relativism. Traditionally, the theory argues that communities have their own conceptual frameworks of morality that are inaccessible to those outside of the community. Thus, one community cannot give another community a moral reason to change a practice. In this paper, I will examine David Velleman’s version of the theory presented in his book Foundations for Moral Relativism. This version posits that the drive towards mutual interpretability is a universal drive among human (...) communities. From this drive stem all the practices and moral values of communities. However, Velleman does not believe that this implies that communities can understand each others’ conceptual frameworks. In this way, his account remains a normal version of moral relativism. I will argue that there are some cases in which a person can understand a different community’s conceptual framework enough to provide a reason for that community to change a practice. Importantly, my argument will not say that the reasons for change are moral reasons. They will be practical reasons based on the normative fact that human communities should strive towards mutual interpretability. Thus, my account will also maintain the crucial tenets of moral relativism. If accomplished, this argument will add a great power to the theory. (shrink)

According to Russellianism (or Millianism), the two sentences ‘Ralph believes George Eliot is a novelist’ and ‘Ralph believes Mary Ann Evans is a novelist’ cannot diverge in truth-value, since they express the same proposition. The problem for the Russellian (or Millian) is that a puzzle of Kaplan’s seems to show that they can diverge in truth-value and that therefore, since the Russellian holds that they express the same proposition, the Russellian view is contradictory. I argue that the standard Russellian appeal (...) to “ways of thinking” or “propositional guises” is not necessary to solve the puzzle. Rather than this retrograde concession to Fregeanism, appeal should be made to second-order belief. The puzzle is solved, and the contradiction avoided, by maintaining that both sentences are indeed true in addition to the sentence ‘Ralph (mistakenly) believes that he does not believe Mary Ann Evans/George Eliot is a novelist’. (shrink)

The Global Workspace Theory and Information Integration Theory are two of the most currently accepted consciousness models; however, these models do not address many aspects of conscious experience. We compare these models to our previously proposed consciousness model in which the thalamus fills-in processed sensory information from corticothalamic feedback loops within a proposed 3D default space, resulting in the recreation of the internal and external worlds within the mind. This 3D default space is composed of all cells of the body, (...) which communicate via gap junctions and electrical potentials to create this unified space. We use 3D llustrations to explain how both visual and non-visual sensory information may be filled-in within this dynamic space, creating a unified seamless conscious experience. This neural sensory memory space is likely generated by baseline neural oscillatory activity from the default mode network, other salient networks, brainstem, and reticular activating system. (shrink)

Aims: To describe individuals’ perceptions of the activities that take place within the cancer genetics clinic, the relationships between these activities and how these relationships are sustained. Design: Qualitative interview study. Participants: Forty individuals involved in carrying out cancer genetics research in either a clinical (n = 28) or research-only (n = 12) capacity in the UK. Findings: Interviewees perceive research and clinical practice in the subspecialty of cancer genetics as interdependent. The boundary between research and clinical practice is described (...) as vague or blurred, and this ambiguity is regarded as being sustained by a range of methodological, ethical and economic factors. The implications of these findings for the “therapeutic misconception” are explored. It is argued that while research participation is seen as having therapeutic benefit for individual patients, the interviewees are not labouring under any misconceptions about the relationship between research and clinical care. It is suggested that concepts such as the “therapeutic misconception” may have less relevance in highly technological specialities that are characterised by a developing evidence base. (shrink)

Design: Qualitative interview study. Participants: Fifty-nine patients with a family history of cancer who attend a regional cancer genetics clinic in the UK were interviewed about their current and previous research experiences. Findings: Interviewees gave a range of explanations for research participation. These were categorised as social—research participation benefits the wider society by progressing science and improving treatment for everyone; familial—research participation may improve healthcare and benefit current or future generations of the participant’s family; and personal—research participation provides therapeutic or (...) non-therapeutic benefits for oneself. Conclusions: We discuss the distinction drawn between motives for research participation focused upon self and others, and observe that personal, social and familial motives can be seen as interdependent. For example, research participation that is undertaken to benefit others, particularly relatives, may also offer a number of personal benefits for self, such as enabling participants to feel that they have discharged their social or familial obligations. We argue for the need to move away from simple, static, individualised notions of research participation to a more complex, dynamic and inherently social account. (shrink)

Multilevel research strategies characterize contemporary molecular inquiry into biological systems. We outline conceptual, methodological, and explanatory dimensions of these multilevel strategies in microbial ecology, systems biology, protein research, and developmental biology. This review of emerging lines of inquiry in these fields suggests that multilevel research in molecular life sciences has significant implications for philosophical understandings of explanation, modeling, and representation.

The received view in the history of the philosophy of psychology is that the logical positivists—Carnap and Hempel in particular—endorsed the position commonly known as “logical” or “analytical” behaviourism, according to which the relations between psychological statements and the physical-behavioural statements intended to give their meaning are analytic and knowable a priori. This chapter argues that this is sheer legend: most, if not all, such relations were viewed by the logical positivists as synthetic and knowable only a posteriori. It then (...) traces the origins of the legend to the logical positivists’ idiosyncratic extensional or at best weakly intensional use of what are now considered crucially strongly intensional semantic notions, such as “translation,” “meaning” and their cognates, focussing on a particular instance of this latter phenomenon, arguing that a conflation of explicit definition and analyticity may be the chief source of the legend. (shrink)

Thousands of youth suffering from acquired brain injury or other early-life neurological disease live, mature, and learn with only limited communication and interaction with their world. Such cognitively capable children are ideal candidates for brain-computer interfaces. While BCI systems are rapidly evolving, a fundamental gap exists between technological innovators and the patients and families who stand to benefit. Forays into translating BCI systems to children in recent years have revealed that kids can learn to operate simple BCI with proficiency akin (...) to adults. BCI could bring significant boons to the lives of many children with severe physical impairment, supporting their complex physical and social needs. However, children have been neglected in BCI research and a collaborative BCI research community is required to unite and push pediatric BCI development forward. To this end, the pediatric BCI Canada collaborative network was formed, under a unified goal to cooperatively drive forward pediatric BCI innovation and impact. This article reflects on the topics and discussions raised in the foundational BCI-CAN meeting held in Toronto, ON, Canada in November 2019 and suggests the next steps required to see BCI impact the lives of children with severe neurological disease and their families. (shrink)

Propositionalism is the view that intentional attitudes, such as belief, are relations to propositions. Propositionalists argue that propositionalism follows from the intuitive validity of certain kinds of inferences involving attitude reports. Jubien (2001) argues powerfully against propositions and sketches some interesting positive proposals, based on Russell’s multiple relation theory of judgment, about how to accommodate “propositional phenomena” without appeal to propositions. This paper argues that none of Jubien’s proposals succeeds in accommodating an important range of propositional phenomena, such as the (...) aforementioned validity of attitude-report inferences. It then shows that the notion of a predication act-type, which remains importantly Russellian in spirit, is sufficient to explain the range of propositional phenomena in question, in particular the validity of attitude-report inferences. The paper concludes with a discussion of whether predication act-types are really just propositions by another name. (shrink)

Good people often die badly, and, sometimes, bad people die well. Both are true for complex reasons. We worry that the tropic formulation trades on a simplistic anthropology that belies the complexities of how persons operate in the world. In this essay, we are interested in these complexities and a better theological acknowledgement of them, not least because the fantasy of the good death ill prepares one for real death. We argue that valorizing pious religious death and profane ugly death (...) loses sight of these complexities, which we think should comprise any account Christians give about what persons are and are in their dying—an account that often goes by the name “theological anthropology.” It is the simplistic theological anthropology more than the tropic formulation—the anthropology the trope smuggles in—that concerns us. Our argument proceeds by first examining the fantasy of the good death, measuring it against a historical record with an examination of the Ars Moriendi tradition, and then thinking more broadly about what motivates it. Along the way, we consider a recent film, The Farewell, where good-death fantasies comically run up against death’s reality and where goodness, truth, and beauty show up anyhow. (shrink)

This seminal work by political philosopher C.B. Macpherson was first published by the Clarendon Press in 1962, and remains of key importance to the study of liberal-democratic theory half-a-century later. In it, Macpherson argues that the chief difficulty of the notion of individualism that underpins classical liberalism lies in what he calls its "possessive quality" - "its conception of the individual as essentially the proprietor of his own person or capacities, owing nothing to society for them." Under such a conception, (...) the essence of humanity becomes freedom from dependence on the wills of others; society is little more than a system of economic relations; and political society becomes a means of safeguarding private property and the system of economic relations rooted in property. As the New Statesman declared: "It is rare for a book to change the intellectual landscape. It is even more unusual for this to happen when the subject is one that has been thoroughly investigated by generations of historians.... Until the appearance of Professor Macpherson's book, it seemed unlikely that anything radically new could be said about so well-worn a topic. The unexpected has happened, and the shock waves are still being absorbed." A new introduction by Frank Cunningham puts the work in a twenty-first-century context. (shrink)

Immanuel Kant was a German philosopher. He is a central figure of modern philosophy, and set the terms by which all subsequent thinkers have had to grapple. He argued that human perception structures natural laws, and that reason is the source of morality. His thought continues to hold a major influence in contemporary thought, especially in fields such as metaphysics, epistemology, ethics, political philosophy, and aesthetics.

Most contemporary metaphysicians are sceptical about the reality of familiar objects such as dogs and trees, people and desks, cells and stars. They prefer an ontology of the spatially tiny or temporally tiny. Tiny microparticles 'dog-wise arranged' explain the appearance, they say, that there are dogs; microparticles obeying microphysics collectively cause anything that a baseball appears to cause; temporal stages collectively sustain the illusion of enduring objects that persist across changes. Crawford L. Elder argues that all such attempts to (...) 'explain away' familiar objects project downwards, onto the tiny entities, structures and features of familiar objects themselves. He contends that sceptical metaphysicians are thus employing shadows of familiar objects, while denying that the entities which cast those shadows really exist. He argues that the shadows are indeed really there, because their sources - familiar objects - are mind-independently real. (shrink)

The simulation hypothesis claims that the whole observable universe, including us, is a computer simulation implemented by technologically advanced beings for an unknown purpose. The simulation argument (as I reconstruct it) is an argument for this hypothesis with moderately plausible premises. I develop two lines of objection to the simulation argument. The first takes the form of a structurally similar argument for a conflicting conclusion, the claim that I am a so-called freak observer, formed spontaneously in a quantum or thermodynamic (...) fluctuation rather than through ordinary processes of evolution and growth. The second rejects the basic line of reasoning of both arguments: the sort of evidence they cite is not capable of supporting either the claim that I am a simulant or the claim that I am a freak observer. The evidence that simulants or freak observers exist is not a reason to think that I am one of them. (shrink)

This paper argues that there can be, For each individual mental state, Some identifiable neural "embodiment" only if the brain operates in accord with a hegelian teleological model. "embodiments" are neural configurations which do, Or would, Produce all the behaviors connected with the mental state. The argument hinges on how these behaviors are described: if under predicates of neurophysics only, Then only under wildly disjunctive predicates, Which cannot be projected for any candidate configuration; if under "teleological" predicates, Then under predicates (...) projectible for teleological hardware. Hegel's logic provides for a teleology consistent with modern science. (shrink)

James decides that the best price today on pork chops is at Supermarket S, then James makes driving motions for twenty minutes, then James’ car enters the parking lot at Supermarket S. Common sense supposes that the stages in this sequence may be causally connected, and that the pattern is commonplace: James’ belief (together with his desire for pork chops) causes bodily behavior, and the behavior causes a change in James’ whereabouts. Anyone committed to the idea that beliefs and desires (...) are states installed by evolution must, it seems, think something similar. For how can one see beliefs and desires as conferring selective advantage if not by supposing that, by causing bodily behavior in their subjects, they brought about changes in their subjects’ surroundings? Yet many, many philosophers currently think or worry that mental causation is illusory (see, e.g., Heil and Mele 1993, or Macdonald and Macdonald 1995). Any physical changes which a mental state appears to cause can be viewed as a complex event involving microparticles, and for any such complex event, many philosophers suppose, there will have been previous microphysical occurrences sufficient to cause it. Barring routine overdetermination of such complex events, the apparent causation of mental events seems to be excluded. Nor does it help to say that some salient segment of the previous microphysical event just is the mental event, differently described (Davidson 1970). For describing the previous events as microphysical seems to spotlight the very features in virtue of which they did their causal work; the mental features seem epiphenomenal (Yablo 1992b: pp. 425-36; Yablo 1992a). This paper argues that the complex physical events, which mental events seem excluded from causing, are not caused at all. For they are either accidents, in something like Aristotle’s sense (Sorabji 1980: pp. 3-25), or coincidences, in a sense which David Owens has recently sharpened (Owens 1992). (shrink)

This is a breakthrough work expanding the debate of the dilemmas of life and death in contemporary American society by carrying it beyond the insights of Western religious and philosophic thought to include ethical perspectives of the Hindu tradition. The topics covered are the timely ethical issues that concern both Americans and all people of the world — abortion, suicide, euthanasia, and the environment. A lively East-West dialogue probes the roots of each issue in its native setting, and the fruit (...) of this historical approach is a clear-cut analysis of up-to-date cases, giving their current status in terms of ethics, religion, philosophy, medicine, and law. Unlike traditional textbooks that concentrate on a theoretical analysis to the exclusion of practical issues, this book does justice to both theoretical and practical ethics. (shrink)

The Beginnings of Nietzsche's Theory of Language is concerned with the years 1865 through Winter/Spring 1870-71. Four texts of Nietzsche's, "Vom Ursprung der Sprache", "Zur Teleologie", "Zu Schopenhauer", and "Anschauung Notes", are translated into English and interpreted from the perspective of Nietzsche's developing theory of language. An examination of the major influences of Schopenhauer, Kant, Eduard von Hartmann, and Frederick A. Lange are pursued. ;Theory, in this work, does not assume that it is possible to take a position of authority (...) or truth in the interpretation of texts, rather that interpretation of texts constitutes an attempt to uncover a discursive practice, to describe a discourse-object. The method used is Nietzsche's method of genealogy, which follows the formation of discourse, at once scattered, discontinuous, and regular and analyzes the process of rarefaction, consolidation and unification in that discourse. Genealogy is exegesis in Nietzsche's sense of it as rumination, as the slow, repetitive, gray activity of deciphering what is documented. Major genealogical nodes or elements of Nietzsche's beginning theory of language are used and reused in different contexts throughout the work, resulting in a cumulative effect which explores specific elements in Nietzsche's thinking about language. ;This work offers five major contributions to Nietzsche studies: a detailed introduction of the significant influence of Eduard von Hartmann upon Nietzsche's thinking; a comprehensive look at the influence of Lange's History of Materialism upon Nietzsche's beginning theory of language; a thorough analysis of "Zur Teleologie" and "Zu Schopenhauer" in the overall contexts of Nietzsche's thinking with regard to metaphysics and teleology; the gathering together and interpretation into a world view of the "Anschauung Notes"; and a close examination of Nietzsche's breaking away from Schopenhauer as it takes place before the publication of The Birth of Tragedy. ;Nietzsche's primary contributions to a theory of language in these beginning years are three: the adoption of the role of the unconscious instincts in the origins and ongoing production of language; the assertion that unconscious thought processes are a precondition for conscious thought; an examination of the relationships of language to epistemology, which results in the recognition of the limits of language as an instrument of truth, but a realization of the inestimable value and force of its symbolic and figurative aspects, aspects necessitated by the very nature of language itself. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Philosophy and Rhetoric 33.1 (2000) 96-99 [Access article in PDF] Book Review The Long Path to Nearness: A Contribution to a Corporeal Philosophy of Communication and the Groundwork for an Ethics of Relief The Long Path to Nearness: A Contribution to a Corporeal Philosophy of Communication and the Groundwork for an Ethics of Relief. Ramsey Eric Ramsey. Atlantic Highlands, NJ: Humanities Press, 1998. Pp. xiv + 145. $49.95, cloth. (...) The cryptic title of Ramsey Eric Ramsey's new text creates a very useful metaphor that runs, as a long, sometimes winding, path through the wooded grounds of philosophy, communication, and ethics. The distance of the journey to corporeal communication and an ethics of relief is long in the sense that the journey requires most readers to shed some perceptual baggage as payment for passage. An example of such baggage shedding is Ramsey's effort to "re-call" communication. A valuable section of his work, it elicits an interesting new metaphorical perception of that which we take for granted.The premise that Ramsey works under is an acknowledged one of a critical existential Marxist who is influenced by Martin Heidegger. The additional [End Page 96] frame of this project is Calvin O. Schrag's 1987 book Communication Praxis and the Space of Subjectivity; indeed, Ramsey posits this work as a "building upon" Schrag's contribution. Certainly, in the use and understanding of communicative praxis, Ramsey does extend the work of Schrag. But there is more to Ramsey than new chapters in a story told earlier.Ramsey presents two arguments, along with well-sculpted, carefully detailed supporting premises that make the unfolding an enjoyable process. The issues of The Long Path to Nearness are (1) the neglected body in communication theory, which represents the inescapable contact point with the natural world, and (2) liberation ethics, explicated from an understanding of the absoluteness of uncertainty and the implications of responsibility. The arguments are fashioned around a Heideggerian "being-in-the-world" consciousness, one that, in its essence would presuppose both the body and the other as pretheoretical. Ramsey takes another approach, however, and avoids the transcendental while arguing, in a later context, for the transcendent.The long path begins with a phenomenological explication of the corporeal body, with a frequent and consistent implication of praxis as a sort of journey signpost (50 miles to Dallas... then 40 miles to Dallas, etc.) reminding the reader that practice is essential to the understanding of communication corporeality. In "re-calling" communication, Ramsey defines communication as a dynamic practice that offers possibility, possibility shaped by the binary of active and passive moments. For Ramsey's project, the passive moment is that which represents the material world and the inescapable Dasein that implies the body. Ramsey does not argue for an intercorporeality, choosing instead to imply the concept with a "being-in-the-world-with-other" perspective in the context of the corporeality argument. The active moment is the moment of subjectivity, which represents the consciousness of intentionality. Given Heidegger's definition of logos as "speaking" and Ramsey's professed phenomenological perspective (a study of being as opposed to knowing), possibility for Ramsey represents communication as "being-in-the-world-speaking" through a consciousness of intentionality and a material body presence. This presence in the world is practiced, negotiated, and experienced through communication.Ramsey's argument of possibility is an intricate exploration of the potentiality of horizons that are open-ended, endlessly challenging, and inviting potentiality for an ethics of liberation. Ramsey's explication of possibilities is one of the significant offerings of this effort, and is worth examination on the basis of its nuances and constructions.The overall argument for corporeality will be largely familiar to a European audience immersed in the body politic. This is not to say that the [End Page 97] effort does not offer new and inviting understandings, but rather to suggest that the premises of Ramsey's work best relate to those of continental thought regarding body presence. For those who... (shrink)

Empty judgements appear to be about something, and inaccurate judgements to report something. Naturalism tries to explain these appearances without positing non-real objects or states of affairs. Biological naturalism explains that the false and the empty are tokens which fail to perform the function proper to their biological type. But if truth is a biological 'supposed to', we should expect designs that achieve it only often enough. The sensory stimuli which trigger the frog's gulp-launching signal may be a poor guide (...) to the signal's content. Teleosemantics should be anti-verificationist. (shrink)

The complex activity of the human brain makes it difficult to get a big picture of how the brain works and functions as the mind. We examine pertinent studies, as well as evolutionary and embryologic evidence to support our theoretical model consisting of separate but interactive layers of human neural activity. The most basic layer involves default mode network (DMN)activity and cardiorespiratory oscillations. We propose that these oscillations support other neural activity and cognitive processes. The second layer involves limbic system (...) activity accompanied by corresponding changes in cardiorespiratory oscillations. The third layer consists of corticothalamic processing and involves higher cortical functions including awareness, cognition,and consciousness. These layers interact to form the complex neural activity of the human brain. Examining the origins and relationships of various neural and physiologic oscillations may provide better understanding of human neurophysiology and consciousness. (shrink)

The ability to quickly and accurately recognise emotional states is adaptive for numerous social functions. Although body movements are a potentially crucial cue for inferring emotions, few studies have studied the perception of body movements made in naturalistic emotional states. The current research focuses on the use of body movement information in the perception of fear expressed by targets in a virtual heights paradigm. Across three studies, participants made judgments about the emotional states of others based on motion-capture body movement (...) recordings of those individuals actively engaged in walking a virtual plank at ground-level or 80 stories above a city street. Results indicated that participants were reliably able to differentiate between height and non-height conditions (Studies 1 & 2), were more likely to spontaneously describe target behaviour in the height condition as fearful (Study 2) and their fear estimates were highly calibrated with the fear ratings from the targets (Studies 1-3). Findings show that VR height scenarios can induce fearful behaviour and that people can perceive fear in minimal representations of body movement. (shrink)

This paper opposes universal mereological composition (UMC). Sider defends it: unless UMC were true, he says, it could be indeterminate how many objects there are in the world. I argue that there is no general connection between how widely composition occurs and how many objects there are in the world. Sider fails to support UMC. I further argue that we should disbelieve in UMC objects. Existing objections against them say that they are radically unlike Aristotelian substances. True, but there is (...) a stronger objection. This is that they are characterized by no properties, and so fail to be like anything – even themselves. (shrink)

Postmodern, poststructural, and critical theorists say that there are no universally valid foundations for norms. Whether or not we think that ethics exists in international life, or ought to, these theorists maintain that there are no firm grounds for any particular ethical belief. Rather, they argue, ethics is contextual.Many, perhaps most, students of international ethics believe that such approaches have little to offer considerations of international ethics. Christopher Norris says postmodernists are nihilists: “Postmodernism is merely the most extreme (or as (...) some would say, most consistent and consequent) version of this desire to have done with all truth-claims beyond what is presently and contingenty ‘good in the way of belief.‘” Ken Booth argues: “If one scratches a committed post-modernist one will almost certainly find a comfortably well-off Western urban liberal. Those who live against the wall, or who have emancipated themselves from such a position, do not hold these views.… The reason for this is obvious, and relates to the fact that post-modernism—certainly that of a doctrinaire variety—does not deliver an ethics for the emancipation of victims across the world.”. (shrink)

Intercellular signaling plays an important role in spatially regulated developmental processes. Myxococcus xanthus C signal transmission during fruiting body formation requires motile, densely packed, well aligned cells. tThe fruiting body consists of two domains: an outer domain which has densely packed, well aligned, motile cells: and an inner domain of more loosely packed, non‐motile, sporulating cells. The two domains are characterized by different patterns of C‐dependent gene expression, which begins in the outer domain where C‐signaling is most efficient, and reaches (...) its maximum in the inner domain. These domains may be maintained by a dynamic mechanism which relies on passive transport of the sporulating cells from the outer domain, where sporulation is initiated, to the inner domain by the motile cells in the outer domain. (shrink)