One of the debated issues regarding Residual Normality (RN) is frequency sensitivity in Williams syndrome (WS). We present some data on frequency sensitivity in Hungarian WS subjects. Based on vocabulary measures, we suggest that instead of the across-the-board frequency insensitivity proposed by some, a higher frequency threshold characterizes these subjects’performance. Results from a category fluency task show that whereas frequency sensitivity in WS is in line with controls, error patterns imply a qualitatively distinct, looser categorical organization. Regarding the much-debated (...) issue of morphological overgeneralizations, our data suggest that frequency sensitivity cuts across the divisions proposed by dual-process theories. In general, some of the frequency effects are the same as in typically developing populations, but with a delayed pattern. Frequency may be interpreted as supporting RN, but in WS it operates with higher thresholds that might be a general processing feature of WS individuals. (shrink)

This paper investigates the acquisition of residual verb second (V2) in three corpora consisting of data from Norwegian-English bilinguals (Emma, Emily, and Sunniva) in order to determine to what extent these structures are affected by cross-linguistic influence (CLI) from Norwegian V2. The three girls exhibit three different patterns with regard to the relevant constructions. They are very target-like in their use of auxiliaries in the relevant structures. However, when it comes to do-support, Emily and Sunniva are equally target-like, while (...) Emma mainly produces non-target-like structures. These either involve the omission of do, or non-target-like movement of a lexical verb. Furthermore, Emma also allows verb movement across the subject with both lexical verbs and auxiliaries in topicalized structures, suggesting that she has overgeneralized residual V2 across verb types and clause types. Emily, on the other hand, is very target-like in structures involving residual V2 in English, but also allows auxiliaries and dummy-do to move across the subject in topicalized structures, overgeneralizing residual V2 to apply to non-subject-initial declaratives. Finally, Sunniva, is very precocious and very target-like in all the relevant structures, which may be an indication of acceleration due to CLI from Norwegian V2. We discuss these results with reference to language balance, finding that the measures available to us suggest that the differences between the children cannot straightforwardly be explained by language dominance. Instead, we suggest that these results can be accounted for by ambiguity in the English system, leaving the data open to several possible interpretations when acquired in contact with the consistent V2 system in Norwegian. This has several consequences: (i) the three girls’ parsers interpret the input differently, (ii) differences between the three children are qualitative rather than quantitative, and (iii) there has to be some mechanism that ensures that the children can ‘recover’ from these non-target-like grammars. In this paper, we will focus on the first two issues. (shrink)

Very few attempts have been made to survey patient opinions, particularly regarding the use of residual biospecimens and health information in research, to clarify their values. We conducted a questionnaire survey that targeted outpatients of a university hospital to gauge their awareness levels and understand patient perspectives on research that uses these items. Few patients felt that obtaining individual consent for each research study was necessary. Most patients expressed the view that researchers should be obligated to inform them about (...) the research use of their items and be subject to self-directed rules. The research community should try to obtain “societal consent regarding an opt-out system” from the public. A salient value-sharing-based governance structure is necessary for obtaining public trust. (shrink)

Abstract:I argue that while social theorists have striven to recognize the connections between subjectivity and environmental degradation, our efforts have to some extent been outflanked by industrialism's historical assimilation of thought and experience. This entanglement with industrialist conceptions has led to both theoretical confusion and personal despondency. I argue that in contrast to popular narratives of enhanced individual choice and human domination in the Anthropocene, there has been a narrowing of human awareness and reason over the past several centuries, and (...) that the role of the person in industrial societies has been progressively subordinated to the interests and organization of the industrial order. As a result, feelings of apathy, powerlessness, and depression reflect a residual and realistic embodied awareness of our assimilation into a context that we are discouraged from recognizing. I end by considering how we might transcend this narrowed subjectivity and rediscover our continuity with the natural world. (shrink)

To what extent can one be saddled with responsibility or guilt as a result of actions committed not by oneself but by others with whom one has a familial or national connection or some other communal association? The issue of communal guilt has been extensively discussed, and there has been no shortage of writers willing to apply the notion of communal responsibility and guilt to Germany after the Holocaust. But the whole notion of communal guilt is deeply puzzling. How can (...) evil actions cast a shadow over the future in this way to generate obligations or guilt on the part of those who did not in any way participate in those actions? In this article, I will focus on a question that is a smaller-scale analogue of the question of communal guilt, one which raises similar perplexities but in a more tractable way. I will concentrate on the restoration of relations with perpetrators of great evil in cases in which their whole-hearted repentance is not in doubt. Most of us feel a strong antipathy to the restoration of relations with such a perpetrator. What explains and supports that emotive reaction is the subject of this article, and its conclusions are suggestive of promising approaches to the question of communal guilt. (shrink)

Growth modelling is of interest to scientists in various disciplines. In our article, we will collect 17 models designed for growth modelling, appraise these models and contribute to the discussion of their applicability. The merit of the paper lies in studying the convergence properties of nonlinear regression in selected models. Our studies will be performed mainly concerning the quality of the obtained estimates, which are closely related to the intrinsic curvature of the model according to Bates and Watts. This curvature (...) determines the size of the linearization domains. Only if the initial solution is in this domain, then the convergence of the estimate in nonlinear regression is guaranteed. The primary goal is to design a methodology for selecting a growth model. We will demonstrate fruitfulness of our methodology on the weight measurements of 10 calves under 25 months of age from cowsheds in the village Záluží in the Czech Republic. Estimated parameters of growth curves, sizes of linearization domain, calculated residues and coefficients of determination indices will be the subject of discussion. (shrink)

Kant's account of subjectivity is ambiguous: there is an implicit critique of Descartes in Kaaat, but this is in conflict with more Cartesian aspects of his approach to subjectivity. Fichte develops the critical elements of Kant and turns them against Kant's residual Cartesianism. Fichte, in the various versions of the Wissenschaftslehre, is the first to be aware of the limitations of the reflective model of consciousness. In those texts he presents his alternative model for subjectivity by trying to conceive (...) of selfconsciousness such that the self-relation makes no separation between thinker and thought. While Fichte's insight into the limitations of the reflective model of consciousness is generally accepted, his own account of the character of the immediate self-relation, which he presents as the alternative to the reflective model, was never satisfactorily resolved. The exposition of Fichte will examine his theory of subjectivity in relation to the central notion of striving; it will be argued that the notion of a striving subject tries to reconcile the dichotomy of idealism and realism. (shrink)

Freudian and phenomenological approaches to subjectivity allow the existence of a residual core self. Recent work within cultural analysis and sociology has rejected such a residue. The writings of Judith Butler and Pierre Bourdieu are two cases in point. In the former case, this refusal functions to provide the possibility of reconstructable gendered identities. For Bourdieu, it confirms the primacy of the social. In both cases, the refusal is part of a case made against psychological essentialism. However, the campaign (...) against essentialism may not be served by the rejection of all aspects of the autonomous embodied self. As a test of the implications of this self-denial, an examination is made of the shift in transsexual discourse from the early culture of dissimulation to current trends of openness and the transcendence of dichotomous models of gender. It is shown that the model of citation found in the work of Judith Butler works poorly in the early stage, but works well in the later culture if stripped of its contingent association with dissimulation. The culture of open citation is shown to be dependent upon external certitudes which duplicate, in potentially stronger terms, the very essentialism which the rejection of residual selfhood was first meant to defeat. (shrink)

This essay is an inquiry into John McDowell’s thinking on ‘subjectivity.’ The project consists in two parts. On the one hand, I will discuss how McDowell understands and responds to the various issues he is tackling; on the other, I will approach relevant issues concerning subjectivity by considering different aspects of it: a subject as a perceiver, knower, thinker, speaker, agent, person and (self-) conscious being in the world. The inquiry begins by identifying and resolving a tension generated by (...) the very idea of ‘rational animal’: human beings are at the same time natural and rational. Later the inquiry proceeds by considering how McDowell’s notion of ‘second nature’ enables us to be human subjects with many faces. By going through the diagnoses and responses of McDowell, two central problems in modern and contemporary philosophy – the narrow conception of nature and the Cartesian inner space model – are identified and repelled. In Episode N I first urge that we should leave room for a certain notion of ‘world.’ I further argue that mentality has many aspects, and to understand those aspects is to understand the many faces of human subject. In Episode Ⅰ the Aristotelian notion of ‘second nature’ is discussed in order to resolve the tension in the very idea of ‘rational animal.’ Later I reply to some worries about this maneuver, including the objection from Crispin Wright. Hans-Georg Gadamer’s distinction between world and environment is introduced and related to McDowell’s thinking. Episode Ⅱ discusses perception and knowledge; McDowell’s main target – the Cartesian inner space – is introduced and criticized. Barry Stroud’s and Simon Blackburn’s positions are evaluated. Later I connect the main theme of Mind and World to the present context; in particular, I discuss McDowell’s invocation of Donald Davidson and Immanuel Kant. And then I discuss a common accusation of idealism, and Robert Brandom’s accusation of ‘residual individualism.’ Episode Ⅲ concentrates on Saul Kripke’s Wittgenstein, arguing that the master thesis behind the rule-following paradox is a version of the inner space model, and that Kripke’s Wittgenstein is not Wittgenstein. Martin Kusch’s objections are answered; Michael Dummett’s demand of reductionism is rebutted. After this, I turn to Davidson’s ‘no language’ claim, and discuss to what extent McDowell agrees with him. In Episode Ⅳ I evaluate objections from Hubert Dreyfus concerning action and agency. I discuss how Dreyfus and Maurice Merleau-Ponty commit ‘the Myth of the Disembodied Intellect’ identified by McDowell. I answer Michael Ayer’s charge of intellectualism in passing. Later I bring in McDowell’s objections to Derek Parfit on personhood and to Davidson on the mind-body relation. In Episode Ⅴ I focus on consciousness and self-consciousness. McDowell applies his argument against Parfit to Kant, but Maximilian de Gaynesford dissents. I reply to his objections on McDowell’s behalf. I further connect this to McDowell’s attacks on the dualism of scheme and content. This leads to my McDowellian rejection to the existence of qualia, and further brings me to the debate between intentionalism and disjunctivism in the context of the argument from illusion. I argue against Tim Crane’s ways of conceiving issues about intentionalism and the argument from illusion. Varieties of disjunctivism are also discussed. In my Epilogue, I express my worry about McDowell’s notion of ‘self-determining subjectivity.’ According to McDowell, human freedom consists in causations in the space of reason, but as Richard Gaskin points out, a satisfying story of it is yet to be provided. I close this essay with some rough ideas about how to fill in the details of the McDowellian picture. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:The Social, the Outer and the ReflexiveSome More Dimensions of Subjectivity, Schizophrenia, and Its RecoveryThe author reports no conflicts of interest.First of all, I want to express my gratitude to the Association for the Advancement of Philosophy and Psychiatry, Philosophy, Psychiatry, & Psychology, and the Karl Jaspers Award Committee for their recognition of my paper "Institution or individuality? Some reflections on the lessons to be learned from personal accounts (...) of recovery from schizophrenia" (Wannberg, 2024). I am also very thankful for Dr. Paul B. Lieberman's (2024) and Pr. Elizabeth Pienkos' (2024) stimulating comments on the paper.In the original paper, I used the case of the first person accounts of recovery from schizophrenia as a paradigm to elucidate the components of subjectivity more generally, as well as their logical relations. My main point was that considering the "recovery claim" as potentially endowed with a meaning sufficiently close to the official definition of the "personal" sense of recovery at stake—that is, in brief, having "become oneself" despite recurring or residual symptoms—invites us to question current phenomenological, narrative and constructionist approaches of the self in psychopathology. By contrast to these, I stressed the need of a conception of the self more sensible to its social and interpersonal dimensions, which I attempted to sketch out notably by resorting to Wittgenstein's (1953/1997) idea of "grammar." I am very happy that both Lieberman and Pienkos see the appeal to the social as a welcome move with regard to prevailing approaches to schizophrenia and its recovery. But what does it really mean for the subjective or the individual to be socially and interpersonally constituted, and how are we to account for that? [End Page 75]At a first glance, appealing to the social seems to be in line with current trends in psychopathology, including, as Pienkos points out, in the phenomenological tradition. She elsewhere announces a "shift in emphasis" currently taking place within phenomenological psychopathology, characterized by an increasing interest in the situated and dated aspects of subjectivity (Pienkos et al., 2023). This is a valuable turn. However, I am quite dubious that the well-known distinction between an "experiential" and a "narrative" self to which Pienkos appeals is apt to do all the conceptual work required to attain a satisfactory conception of the self and its social dimensions. In my original paper, I took the "recovery account" to challenge both these notions. As concerns the experiential dimension, I held that this type of account questions the phenomenologist's assumption that subjectivity is ultimately grounded in lived (self-)experience. Provided that typical symptoms of schizophrenia (e.g., thought insertion) are expressions of a disorder situated at this most "fundamental" level of the self and provided that they are stemming, at least according to one of the most widespread phenomenological models, from a trait-like disposition present before the onset of psychosis (e.g., Henriksen et al., 2019), it is quite natural to think that these symptoms persist in some form in the context of recovery (e.g., as intrusive thoughts or as "thoughts spoken out loud"). This is indeed the case for several of the authors "in recovery" in the Schizophrenia Bulletin's archives (e.g., Greenblat, 2000), which provided the main source of my analysis. But if this is so, we cannot see their recovery claim as an expression of a "whole" self, so to speak. So we must either say that "personal" recovery from schizophrenia is an illusion or a contradiction, or else we must revise the foundational status of the experiential dimension (other possible options are left aside for the purposes of this brief comment). I argue for the revisionist option. For the equation between the subjective and the experiential does not only lead to an unwelcomed skepticism about the recovery account. There are also more straightforward philosophical reasons for refusing it. Wittgenstein (1980) made a first important step by inviting us to better take into account the variability of the psychological concepts. He notably made a crucial categorical distinction between "lived experiences" (like sensations and mental images) and "attitudes" (like beliefs and intentions) such that all concepts which, when used in the first person... (shrink)

Motility impairments resulting from spinal cord injuries and cerebrovascular accidents are increasingly prevalent in society, leading to the growing development of rehabilitative robotic technologies, among them exoskeletons. This article outlines how bodies with neurological conditions such as spinal cord injury and stroke engage in processes of re-appropriation while using exoskeletons and some of the challenges they face. The main task of exoskeletons in rehabilitative environments is either to rehabilitate or ameliorate anatomic functions of impaired bodies. In these complex processes, they (...) also play a crucial role in recasting specific corporeal phenomenologies. For the accomplishment of these forms of corporeal re-appropriation, the role of experts is crucial. This article explores how categories such as bodily resistance, techno-inter-corporeal co-production of bodies and machines, as well as body work mark the landscape of these contemporary forms of impaired corporeality. While defending corporeal extension rather than incorporation, I argue against the figure of the ‘cyborg’ and posit the idea of ‘residual subjectivity’. (shrink)

Georges Bataille is remarkably absent from Gilles Deleuze’s oeuvre, even though early commentators like Michel Foucault, in his ‘Theatrum Philosophicum’, recognised an obvious affinity between the two thinkers. Direct references to Bataille in Deleuze’s published works are few and far between, and most of them are barely more than offhand remarks. In these few comments, Deleuze’s treatment of Bataille seems to oscillate between contempt and admiration. In an astonishing footnote within the Anti-Oedipus, Bataille’s concept of ‘sumptuary, non-productive expenditure’ is equated (...) with Deleuze’s and Guattari’s concept of the ‘production of consumption’. Taking this passing remark seriously would mean finding Bataille at the very heart of Deleuze’s thought. This paper, therefore, seeks to investigate the traces of Bataille in Deleuze’s work, in order to evaluate the footnote in question. I will show that the equivocation of ‘sumptuary, non-productive expenditure’ and ‘production of consumption’ is indeed warranted and that Deleuze’s thought is far closer to Bataille’s than Deleuze ever cared to admit. Bataille emerges as a great precursor to the thought of immanence, difference, and the event. (shrink)

The traditional debate about moral dilemmas concerns whether there are circumstances in which an agent is subject to two obligations that cannot both be fulfilled. Realists maintain there are. Irrealists deny this. Here I defend an alternative, methodologically-oriented position wherein the denial of genuine moral dilemmas functions as a regulative ideal for moral deliberation and practice. That is, moral inquiry and deliberation operate on the implicit assumption that there are no genuine moral dilemmas. This view is superior to both (...) realism and irrealism in accounting for moral residue and other crucial phenomenological dimensions of our experience of moral dilemmas. (shrink)

BackgroundAssessing consciousness in other subjects, particularly in non-verbal and behaviourally disabled subjects (e.g., patients with disorders of consciousness), is notoriously challenging but increasingly urgent. The high rate of misdiagnosis among disorders of consciousness raises the need for new perspectives in order to inspire new technical and clinical approaches. Main bodyWe take as a starting point a recently introduced list of operational indicators of consciousness that facilitates its recognition in challenging cases like non-human animals and Artificial Intelligence to explore their relevance (...) to disorders of consciousness and their potential ethical impact on the diagnosis and healthcare of relevant patients. Indicators of consciousness mean particular capacities that can be deduced from observing the behaviour or cognitive performance of the subject in question (or from neural correlates of such performance) and that do not define a hard threshold in deciding about the presence of consciousness, but can be used to infer a graded measure based on the consistency amongst the different indicators. The indicators of consciousness under consideration offer a potential useful strategy for identifying and assessing residual consciousness in patients with disorders of consciousness, setting the theoretical stage for an operationalization and quantification of relevant brain activity.ConclusionsOur heuristic analysis supports the conclusion that the application of the identified indicators of consciousness to its disorders will likely inspire new strategies for assessing three very urgent issues: the misdiagnosis of disorders of consciousness; the need for a gold standard in detecting consciousness and diagnosing its disorders; and the need for a refined taxonomy of disorders of consciousness. (shrink)

Bracha Ettinger (formerly known as Bracha Lichtenberg Ettinger) is an Israeli-born Paris-based artist, analyst and feminist theorist who has produced over the last decade a major theoretical intervention through a tripartite practice. This article offers an expository introduction and overview of core aspects of her theoretical contribution while relating it to major trends in feminist and general cultural theory of subjectivity, hysteria, memory, trauma and the aesthetic. Organized in several parts, each section addresses the developing vocabulary, terminology and significance of (...) her work. With core concepts are Matrix, metramorphosis, trans-subjectivity, co-poïesis, co-emergence and co-affection, Ettinger’s theory opens out beyond the blind spots of advanced feminist thought. From its independent and original theorization of subjectivity-as-encounter and an-other sexual difference, Bracha Ettinger challenges our attempts to think about femininity associated with the work of Julia Kristeva and Luce Irigaray. Linked to, but distinct from, the philosophical speculations of Deleuze and Levinas, this work creates a transferential theoretical space for Jewish and feminine difference, sexuality, subjectivity and the traumatic residues of modern catastrophe that has major repercussions for cultural, aesthetic, ethical, political and psychoanalytic theory. (shrink)

The romanticization of the ‘non-human’ which implicitly ideologizes and transhumanizes modern thought in the form of all that is associated with object-oriented ontology, builds not only on obvious starting points (‘deep ecology’, the philosophy of Deleuze and Guattari), but also tries to rethink ‘in its favor’ antagonistic paradigms and discourses. These include the Freudian-Lacanian psychoanalysis. In this article, we will show that not only an external orientation, but also internal gaps, can create an impetus for such a ‘neutralization’. Jacques Lacan’s (...) attempt to remain ‘loyal’ both to the ‘classical subject of the soul’ and to the Real (pre-/beyond-subjective, residual) has resulted in a contradictory concept of desire, having a paradoxical implosive potential which, in turn, was unlocked by the new-materialist, post/transhumanist reading of Lacan. The analysis of desire topic, fundamental to Lacan’s clinical methodology, shows how fragile and susceptible to external attacks is the hermetic conceptual apparatus developed for purely clinical purposes. Based on the logic of Lacan himself, who defined psychoanalysis as a symptom of a concomitant era, we have to state that formal attempts to dissociate oneself from ‘ordinary reality’ cannot save one from the crucible of history, and this fatality is always present in inescapable traps of language. In the vein of psychoanalysis understood as an ‘impossible profession’, the attempt to dialecticize Freud’s thermodynamic ‘biologism’, the fiasco of the Western subject ‘after Auschwitz’ and the belief in the immanence of interpersonal communication, has turned out to be an ‘impossible project’ for Lacan. (shrink)

The attribution of beliefs and other propositional attitudes is best understood as a form of measurement, however counter-intuitive this may seem. Measurement theory does not require that the thing measured should be a magnitude, or that the calibration of the measuring instrument should be numerical. It only requires a homomorphism between the represented domain and the representing domain. On this basis, maps measure parts of the world, usually geographical locations, and 'belief' statements measure other parts of the world, namely people's (...) aptitudes. Having outlined an argument for this view, I deal with an obvious objection to it: that self-attribution of belief cannot be an exercise in measurement, because we are all aware, from introspection, that our beliefs have an intrinsically semantic form. Subsequently, I turn to the philosophical and methodological ramifications of the measurement theoretic view. I argue, first, that it undermines at least one version of constructivism and, second, that it provides an effective alternative to the residually Cartesian philosophy that underpins much qualitative research. Like other anti-Cartesian strategies, belief-attribution-as-measurement implies that the objective world is far more knowable than the subjective one, and that reality is ontologically prior to meaning. I regard this result as both plausible and welcome. (shrink)

This paper considers debates around the neoliberal governmentality, and argues for the need to better theorize the specific ethical practices through which such programs of governmentality are carried out. Arguing that much theoretical and empirical work in this area is prone to a “top down” approach, in which governmentality is reduced to an imposing apparatus through which subjectivities are produced, it argues instead for the need to understand the self-production of subjectivities by considering the ethical practices that make up neoliberal (...) governmentality. Moreover, taking Robert T. Kiyosaki’s Rich Dad/Poor Dad as an illustrative case, the point is made that the work of neoliberal governmentality specifically targets the temporalities of conduct, in an attempt to shape temporal orientations in a more entrepreneurial form. Drawing on Foucault’s lecture courses on liberalism and neoliberalism, and Jacques Donzelot’s work on the social, the case is made that neoliberal governmentality exhorts individuals to act upon the residual social temporalities that persist as a trace in the dispositions of neoliberal subjects. Moreover, the paper concludes with a discussion of the potentials for resistance in this relation, understood as temporal counter-conducts within neoliberalism. (shrink)

In March of 2012, following a robust activist campaign, Arysta LifeScience withdrew the soil fumigant methyl iodide from the US market, just a little over a year after it had finally been registered for use in California. As a major part of the campaign against registration of the chemical, over 53,000 people, ostensibly acting as citizens rather than consumers, wrote public comments contesting the use of the chemical for its high toxicity. Although these comments had marginal impact on the outcome (...) of the case, these comments are of interest for what they say about public action at a time when efforts to address food and agricultural issues have been dominated by “voting with your fork.” Based on a qualitative textual analysis of approximately 3500 representative comments made available to us, we show that many of those taking action did not abandon consumer subjectivities associated with neoliberal governmentality. By threatening “personal boycotts,” some were acting in their capacity as individual consumers; in invoking their own and their children’s health many more were also acting on behalf of consumers, despite that the chemical in question is applied before strawberries are planted and thus leaves no residues. The emphasis that letter writers gave to their own bodies reinforces the idea that some bodies count more than others and thus reveals a biopolitical sorting. Having consumer lives matter is consequential in light of evidence that consumer concern about pesticides has historically led to formulations and regulations more protective of consumers than workers and neighbors. (shrink)

According to the Dogmatism Puzzle, knowledge breeds dogmatism: if a subject knows a proposition h, then she is justified in disregarding any future evidence against h, for she knows that such evidence is misleading. The standard, widely accepted, solution to the puzzle appeals to the defeasibility of knowledge. I argue that the defeat solution leaves intact a residual dogmatist puzzle. Solving this puzzle requires proponents of defeat to deny a plausible principle that the original puzzle relies on called (...) Entitlement, a principle stating roughly that knowing that a piece of evidence is misleading entitles one to disregard it. The plausibility of Entitlement should cast doubt not only on the defeat solution, but on an assumption that has often been taken for granted: the falsity of the dogmatist conclusion of the original puzzle. I conclude that we face a dilemma between giving up Entitlement and living with dogmatism. (shrink)

Hegel’s account of the unconscious and his broader philosophy of mind offer us a well worked out form of non-dualist, non-reductionist, non-eliminativist, non-representationalist naturalism. Hegel describes the development of discursively structured thought (and responsiveness to norms) in ethological terms as emerging from initial somatic-sensory states, from states and processes of bodily activity on the part of a feeling soul, and from structured habituation in relation to other subjects. Importantly, earlier, less organized states of sensory awareness and feeling persist as residues (...) underneath cognitive development in “the pit of imagination.” Imagistic and sensory-somatic materials from this pit can burst out, among other things, in dreams, madness, somnambulism, witty conversation, and puns. In the face of the permanent possibility of regressions from cognitive development, a continual activity of self-formation (Bildung) through art and participation in second nature is essential to maturity. (shrink)

This dissertation investigates that which can only be known with the following criteria of knowledge: (i) it is unchangeable; (ii) it cannot be mistaken; (iii) it is identical with its object. It begins by addressing the following questions: what can and cannot exist in solely this sense? Can anything exist in this sense? A further thesis it explores is that the split between the subject of knowledge and the object of knowledge which has given rise to the unexplained and (...) inexplicable residues in the solutions to epistemological problems which have been propounded by Western philosophers. These residues have been a breeding ground for a skepticism which casts doubt on the validity of the philosophic enterprise. It is hoped that this thesis might play some role in indicating a pathway through which faith in the philosophic enterprise may be restored. The approach taken is multi-leveled, at once transcen¬dental, metaphysical, phenomenological and empirical. It is transcendental in that the question is always ‘how is knowledge possible?’ It is metaphysical in that the focal point is always that which is, and not that which seems to be. It is phenomenological in that it is confined to the data of consciousness and makes no attempt to go beyond consciousness. It is empirical in that the final court of appeal for any argument is always pure experience. It is demonstrated that, given the separation of the subject knower from the object of knowledge, knowledge is an impossibility. Separatist views of knowledge are taken up and analyzed, among which are: knowledge as caused by objects; knowledge as the knowledge of an object; knowledge as the correspondence between ideas and objects; knowledge as an act; knowledge as a possession. All these views leave untouched the basic questions: what is knowledge? How is the object of knowledge known? How can knowledge arise in the first place? The existence of the object is then shown to be purely dependent on the existence of the subject, and vice versa. An analysis of experience reveals that no difference between subject and object is ever detected and detectable. The breakdown of experience into subjects and objects is shown to be a purely theoretical interpretation of experience, unjustified and unjustifiable in actual experience. It is finally shown that it is impossible to legitimize ideas of difference, either from the world of objects or from the mind of the subject knower. That there can be an appearance of plurality is demonstrated to rest upon the reality of space and time, existences which prove to be purely ideal. A re-integration of subject and object into the experience from which they have been dirempted provides an explanation of the possibility of know¬ledge, knowledge which is at once certain and of the real. An application of the perspective of non-dualism is suggested to offer philosophic solutions to such epistemological impasses as the relation of language and meaning and the universal and the particular. The relevance of an epistemological inquiry for action is indicated in such a way as to bring knowledge and existence into harmony with each other. The broader aim of the dissertation is to legitimize the philosophic enterprise as a pathway to unchangeable, unmistakable, and unitary knowledge. (shrink)

R. Rorty uncouples cosmopolitanism from emancipation and rejects the latter on both phylogenetic and ontogenetic grounds. Thus: 1. There is no human nature to be emancipated, and 2. The notion of a rational, transcendental and conditioning subject (presupposed by traditional theories of emancipation) is obsolete. He preserves the idea of cosmopolitanism, which, in an effort to avoid foundationalisrn, he associates only with the development and progress of liberal societies. His cosmopolitanism relies on the distinction between persuasion and force and (...) his preference for conversation over rational discourse. In this paper, I discuss Rorty''s claims and trace residues of biologism, positivism, and behaviourism in them. By putting forward an immanent critique of Rorty''s account of cosmopolitanism and emancipation, I defend a non-foundationalist notion of redemption as self-realization and propose a new justification of Rorty''s distinction between force and persuasion. (shrink)

A plausible terminus for the mind-body debate begins by embracing ontological physicalism—the view that there is only one kind of substance in the concrete world, and that it is material substance. Taking mental causation seriously, this terminus also embraces conditional reductionism, the thesis that only physically reducible (i.e., functionalizable) mental properties can be causally efficacious. Intentional/cognitive properties (what David Chalmers calls “psychological” aspects of mind) are physically reducible, but qualia (“phenomenal” aspects of mind) are not. In saving the causal efficacy (...) of intentional/cognitive properties, we save cognition and agency—and even relational facts about the similarities and differences between qualia—but not the intrinsic qualities of qualia themselves, which are physically irreducible and thus causally impotent. As there seems no credible alternative to physicalism as a general worldview, and this is as much physicalism as we can have, physicalism is not the whole truth—but it is the truth near enough. -/- [1. Cartesian Minds Eliminated] [2. The Collapse of Property Dualism] [3. Physicalism at a Crossroads] [4. Can We Reduce Minds?] [5. Living with the Mental Residue] [6. Where We Are with the Mind-Body Problem] [7. Beyond the Mind-Body Problem: Self and Subjectivity]. (shrink)

Although speech categories are defined by multiple acoustic dimensions, some are perceptually weighted more than others and there are residual effects of native-language weightings in non-native speech perception. Recent research on nonlinguistic sound category learning suggests that the distribution characteristics of experienced sounds influence perceptual cue weights: Increasing variability across a dimension leads listeners to rely upon it less in subsequent category learning (Holt & Lotto, 2006). The present experiment investigated the implications of this among native Japanese learning English (...) /r/-/l/ categories. Training was accomplished using a videogame paradigm that emphasizes associations among sound categories, visual information, and players’ responses to videogame characters rather than overt categorization or explicit feedback. Subjects who played the game for 2.5 h across 5 days exhibited improvements in /r/-/l/ perception on par with 2–4 weeks of explicit categorization training in previous research and exhibited a shift toward more native-like perceptual cue weights. (shrink)

Hegel had taken the Kantian categories of thought to be merely formal, without content, since, he argued, Kant abstracted the conditions of thought from the world. The Kantian categories can, as such, only be understood subjectively and so are unable to secure a content for themselves. Hegel, following Fichte, tried to provide a content for the logical categories. In order to reinstate an objective status for logic and conceptuality he tries to affirm the unity of thought and being. The idea (...) that this unity is established by reinstating a pre-Kantian metaphysics has in most of the recent Hegel literature been discredited. In the wake of this non-metaphysical Hegel there is a concern that the architectonic of concepts which is taken as the organizing principle of consciousness offers an account of experience which is too schematic. While Hegel disputes the intuition/concept distinction as it is played out in Kant and Fichte, he does nevertheless retain some residue of a notion of intuition in his theory of the Concept. This is central to understanding his notion of experience as it can't simply be equated with rule governed conceptuality. Satisfying the demands of reason for Hegel requires more than conceiving our experience solely as judgments. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Rhetorical Agency as a Property of QuestioningNick TurnbullAttention to agency has increased with the ongoing crisis of thought arising from the critique of metaphysics. With the absence of a foundation for reason comes an increased scope for choice in the interpretation of the world and the necessity to persuade others where demonstrative reason is lacking. Hence the "rhetorical turn" accompanies the problematization of knowledge. Even identity itself has been (...) "rhetoricized" with the death of the subject, and attention turns to how discourse constructs knowledge of the world and of ourselves. The rhetorical turn supports an increased capacity of agency in the use of language to construct identity and to relate to others. Agency is a fundamental property of rhetoric: we can debate the discourse of an interlocutor through resort to argumentation even if, as Gerard Hauser notes in the call for papers, that interlocutor is a monster. Philosophy itself has been rhetoricized in that the many philosophical systems of history have been revealed to be unsupportable now that there is no firm foundation upon which to ground inference in general. In a discourse without foundations we are free to choose between different philosophies, so much so that some have rejected philosophy itself in favor of general arbitrariness. This is apparent in deconstruction in philosophy and the rehabilitation of sophism within rhetoric.Where there is choice there is agency, of the rhetor and the audience. But the agency that is so positive for rhetoric is also that for which rhetoric has been condemned. Rhetoric has long been associated with sophistic, in which discourse can be used to deceive others or to simply demonstrate the status of the rhetor regardless of the truth of the conclusions reached. Rhetorical agency permits deception and stands in contrast with logical demonstration, in which necessity and self-evidence are the hallmarks of ideal reason. We have no choice but to accept necessary conclusions. Hence the apparent weakness of rhetoric in relation to logic and the questionable status [End Page 207] of the ethical properties of agency. And if agency is condemned as relativist, is not humanity condemned along with it? The rise of rhetoric also encompasses the "rhetoric of inquiry," which shows that even science employs rhetorical devices to construct the world and to persuade its audience. Science is especially rhetorical in the process of discovery, which is nonscientific. Nonetheless, the status of rhetoric is still problematic because of the freedom it permits. It is viewed by many as a weakness to be eliminated rather than a positive quality to be embraced. The contrast between rhetorical agency and logical necessity lies at the heart of contemporary debates about knowledge, identity, and postmodernity.In this paper I address the nature of rhetorical agency. This requires an examination of the foundations of knowledge and the division between logic and rhetoric. Although this division has been addressed many times in this journal, I believe it is still useful to revisit the debate. We must try to move beyond the postmodern impasse if knowledge is to progress and if rhetoric is to overcome its residual status. I draw on the philosophy of Michel Meyer, who offers a unique perspective on the status of rhetoric and the nature of philosophy. First, I outline the rhetorical turn as part of an increasing problematization of thought. I suggest that the rhetorical turn is incomplete because although problematicity is present in postmodern times, it remains unthematized on its own terms. The division between logic and rhetoric arises from an underlying conflict between freedom and necessity that suggests we inquire into the nature of the problematic itself. Next, I propose that Michel Meyer offers a solution to the problem by effecting a synthesis of freedom and necessity in his consideration of questioning as the foundation of reason and the consideration of the historical crisis faced by philosophy at the end of the twentieth century. Finally, I suggest that agency can be understood as a fundamental property of questioning that arises from the necessity of questioning as the foundation of reason. Rhetorical agency is thus a defining characteristic of humanity.1.The Aristotelian division of logic and rhetoric separated the necessary from the contingent... (shrink)

BackgroundResearch codes of conduct offer guidance to researchers with respect to which values should be realized in research practices, how these values are to be realized, and what the respective responsibilities of the individual and the institution are in this. However, the question ofhowthe responsibilities are to be divided between the individual and the institution has hitherto received little attention. We therefore performed an analysis of research codes of conduct to investigate how responsibilities are positioned as individual or institutional, and (...) how the boundary between the two is drawn.MethodWe selected 12 institutional, national and international codes of conduct that apply to medical research in the Netherlands and subjected them to a close-reading content analysis. We first identified the dominant themes and then investigated how responsibility is attributed to individuals and institutions.ResultsWe observed that the attribution of responsibility to either the individual or the institution is often not entirely clear, and that the notion ofcultureemerges as a residual category for such attributions. We see this notion of responsible research cultures as important; it is something that mediates between the individual level and the institutional level. However, at the same time it largely lacks substantiation.ConclusionsWhile many attributions of individual and institutional responsibility are clear, the exact boundary between the two is often problematic. We suggest two possible avenues for improving codes of conduct: either to clearly attribute responsibilities to individuals or institutions and depend less on the notion of culture, or to make culture a more explicit concern and articulate what it is and how a good culture might be fostered. (shrink)

Over recent years, brain-computer interface (BCI) has emerged as an alternative communication system between the human brain and an output device. Deciphered intents, after detecting electrical signals from the human scalp, are translated into control commands used to operate external devices, computer displays and virtual objects in the real-time. BCI provides an augmentative communication by creating a muscle-free channel between the brain and the output devices, primarily for subjects having neuromotor disorders, or trauma to nervous system, notably spinal cord injuries (...) (SCI), and subjects with unaffected sensorimotor functions but disarticulated or amputated residual limbs. This review identifies the potentials of electroencephalography (EEG) based BCI applications for locomotion and mobility rehabilitation. Patients could benefit from its advancements such as wearable lower-limb (LL) exoskeletons, orthosis, prosthesis, wheelchairs, and assistive-robot devices. The EEG communication signals employed by the aforementioned applications that also provide feasibility for future development in the field are sensorimotor rhythms (SMR), event-related potentials (ERP) and visual evoked potentials (VEP). The review is an effort to progress the development of user’s mental task related to LL for BCI reliability and confidence measures. As a novel contribution, the reviewed BCI control paradigms for wearable LL and assistive-robots are presented by a general control framework fitting in hierarchical layers. It reflects informatic interactions, between the user, the BCI operator, the shared controller, the robotic device and the environment. Each sub layer of the BCI operator is discussed in detail, highlighting the feature extraction, classification and execution methods employed by the various systems. All applications’ key features and their interaction with the environment are reviewed for the EEG-based activity mode recognition, and presented in form of a table. It is suggested to structure EEG-BCI controlled LL assistive devices within the presented framework, for future generation of intent-basedmultifunctional controllers. Despite the development of controllers, for BCI-based wearable or assistive devices that can seamlessly integrate user intent, practical challenges associated with such systems exist and have been discerned, which can be constructive for future developments in the field. (shrink)

The paper brings existential temporality, as developed in the work of phenomenologists Merleau-Ponty, Heidegger, and Husserl, into dialogue with historical materialism. What results is the development of a theoretical background for what the author terms futural materialism, which is taken to be a complimentary logical extension of historical materialist projects. To this end, it is suggested that the past and the future are best understood as materially existing in the present in an immanent way, mediated by conscious beings in the (...) form of memory, projection, residual effect, and affect. Put differently, the present's presence in the past and future play a determining roll in those temporal dimensions, which subsequently fold back into the configuration of the present. Following Nietzsche and drawing influence from Guattari and Deleuze, it is argued that past and future are relatively fluid tools to be purposively deployed in the present for particular purposes rather than being transcendent facts which subjectivity must merely contend with. It is further asserted that as part of a broader non-reductive material monist project of social transformation, both futural and historical materialism are necessary considerations. (shrink)

Shareholders are sometimes considered to be, in moral terms, the owners of a company, they are after all the carriers of the residual liabilities and bear a higher proportion of the financial risk. However, in company law, the shareholders’ responsibility is limited, and in financial terms shareholders are only liable up to the fully paid value of the share certificate. Moreover, when the shares are sold, the responsibility and risk are transferred completely to the new bearer of the shares. (...) Whether this gap in moral and legal perceptions can be judged to be satisfactory in business ethics terms is a moot point and will be partly explored in this case study which seeks to analyse the shareholder’s responsibility towards a firm in which they own shares. The case study company chosen as a vehicle to explore these issues is that of Turner & Newall; a company that subjected its employees, communities and customers to a major health hazard – asbestosis. This paper will use the Turner & Newall archive materials to illustrate the moral hazards that can arise for shareholders. In particular it will examine the ethical responsibilities of shareholders towards those stakeholders who were exposed to the dangers of asbestos. This case is a significant test of the veracity of the legal system of company control, and exposes the ineffectiveness of that system in accountability terms. The case study also deals with specific issues that arose in the asbestos crisis, as well as with more general issues in our present system of corporate governance and shareholder responsibilities. (shrink)

Network Analysis is considered as a new method that challenges Latent Variable models in inferring psychological attributes. With Network Analysis, psychological attributes are derived from a complex system of components without the need to call on any latent variables. But the ontological status of psychological attributes is not adequately defined with Network Analysis, because a psychological attribute is both a complex system and a property emerging from this complex system. The aim of this article is to reappraise the legitimacy of (...) latent variable models by engaging in an ontological and epistemological discussion on psychological attributes. Psychological attributes relate to the mental equilibrium of individuals embedded in their social interactions, as robust attractors within complex dynamic processes with emergent properties, distinct from physical entities located in precise areas of the brain. Latent variables thus possess legitimacy, because the emergent properties can be conceptualized and analyzed on the sole basis of their manifestations, without exploring the upstream complex system. However, in opposition with the usual Latent Variable models, this article is in favor of the integration of a dynamic system of manifestations. Latent Variables models and Network Analysis thus appear as complementary approaches. New approaches combining Latent Network Models and Network Residuals are certainly a promising new way to infer psychological attributes, placing psychological attributes in an inter-subjective dynamic approach. Pragmatism-realism appears as the epistemological framework required if we are to use latent variables as representations of psychological attributes. (shrink)

It is widely accepted that we must adapt to climate change. But we sit on the edge of radical, unprecedented, and rapid anthropogenic environmental changes that are driven by many factors in addition to greenhouse gas emissions. In this way, we occupy a unique and precarious position in the history of our species. Many basic conditions of life on Earth are changing at an alarming rate and thus we should begin to transform and broaden our thinking about adaptation. The conceptual (...) history of climate adaptation intersects with conceptions of human development and sustainability, which provides a framework for adaptation in how we think about human flourishing and, subsequently, what it is to be human in the Anthropocene. If sustainability is about maintaining human welfare across generations but we acknowledge that climate change may undercut our ability to deliver as much and as good total or natural capital to subsequent generations, we have a residual duty to otherwise positively affect the welfare of future generations. A subjective, preference-based conception of human welfare is compared to an objective, capabilities-based approach and, while some adaptive preferences are unavoidable, embracing an objective theory of human flourishing provides a superior approach for meeting the residual duty we have to future generations by beginning the process of adapting our conception of human natural goodness, or what it is to be a good human being. (shrink)

From Sartre to Levinas, continental philosophers have looked to the example of the Jew as the paradigmatic object of and model for ethical inquiry. Levinas, for example, powerfully dedicates his 1974 book Otherwise than Being to the victims of the Holocaust, and turns attention to the state of philosophy after Auschwitz. Such an ethics radically challenges prior notions of autonomy and comprehension-two key ideas for traditional ethical theory and, more generally, the Greek tradition. It seeks to respect the opacity of (...) the other and avoid the dangers of hermeneutic violence. But how does such an ethics of the other translate into real, everyday life? What is at stake in thinking the other as Jew? Is the alterity of the Jew simply a counter to Greek universalism? Is a rhetoric of exceptionalism, with its unavoidable ontological residue, at odds with shifting political realities? Within this paradigm, what then becomes of the Arab or Muslim, the other of the Jew, the other of the other, so to speak? This line of ethical thought-in its desire to bear witness to past suffering and come to terms with subjectivity after Auschwitz-arguably brackets from analysis present operations of power. Would, then, a more sensitive historical approach expose the Palestinian as the other of the Israeli? Here, Zahi Zalloua offers a challenging intervention into how we configure the contemporary. (shrink)

In bringing the philosophical traditions of pragmatism and genealogy to bear upon contemporary debates regarding modernity, the work of both John Dewey and Michel Foucault has been subjected to misinterpretations that portray both traditions in a way that depletes them of the full force of their critical insight. The source of these misinterpretations is in many cases an attempt to squeeze the philosophical projects of pragmatism and genealogy into the mold that shapes the thought of most participants on both sides (...) of the modernity debates. This mold can usually be traced back to the work of the influential sociologist, political economist, and philosopher Max Weber. One unfortunate residue of the subtle dominance of Weberian concepts in contemporary debates over modernity is that many thinkers who operated largely outside of these concepts cannot be brought into these debates without filtering their thought through this conceptual prism. In the case of Dewey and Foucault, their contributions to our understanding of the basic problems of modernity are widely misunderstood due to being filtered through Weberian concepts that simply were not central in Dewey's or Foucault's thinking. By distancing Dewey and Foucault from Weber as concerns their interpretations of modernity a significant point begins to emerge: a hitherto unnoticed convergence between pragmatism and genealogy. This convergence is significant because comparative analyses of pragmatism and genealogy, like those of these two traditions and Weber described above, generally tend to miss the important points of resonance which prove these traditions much closer than is commonly thought. After explicating Weber, Dewey, and Foucault I will conclude my discussion by considering briefly the attractive philosophical possibilities of combing Dewey's work on inquiry as reconstructive problem-solving with Foucault's work on critique as genealogical problematization. (shrink)

John Maynard Keynes, in a biographical essay that is as remarkable for the insight it provides into his own thinking as for what it says about its subject, described the trajectory of Malthus's intellectual career as follows: ‘from being a caterpillar of a moral scientist and chrysalis of an historian, he could at last spread the wings of his thought and survey the world as an economist’. Malthus himself had resisted this conclusion in the introduction to his Principles of (...) Political Economy — meant as a riposte to David Ricardo's way of proceeding — when he stated that ‘the science of political economy bears a nearer resemblance to the science of morals and politics than to that of mathematics’. For understandable reasons, however, some modern economists find Keynes's characterization more attractive, particularly when it also allows them to regret the fact that the free flight of the positive economist in Malthus was often impeded by historical and moral residues left over from earlier existences. By adopting this position they are able to discount awkward problems relating to the historical origins and professional identity of their discipline — those problems connected with Malthus's religious beliefs and theological standpoint that have to be confronted when his explicit claims as a Christian moral scientist are taken seriously. Lack of sympathy on the part of economists when faced with the moral and theological dimensions of Malthus's writings has a long history that goes back to Ricardo, who criticized his friend's confusion, as he saw it, of moral and economic considerations. James Mill, as always, was more outspoken in regretting the intellectual fetters that inevitably went with Malthus's clerical status. Some economic demographers, in modern times, have also criticized Malthus for intermingling ‘moralistic and scientific aims almost inextricably’, thereby imparting what they regard as an untestable or tautological air to his exposition of the population principle. (shrink)

Confessions both hold a great promise and pose a grave danger. When the accused speaks against his interest and assumes responsibility for criminal actions this is viewed as a compelling sign of guilt. It is not, therefore, for naught that the confession has been crowned the "queen of evidence." Yet research conducted in the last few decades has shown that a substantial number of confessions are false, ranking the out of court confession high among the factors leading to the conviction (...) of innocent people. The acceptance of DNA testing, has further substantiated this finding, igniting a renewed interest in out-of-court confessions. It is hard to assess the magnitude of social harm caused by the widespread and persistent resort to obtaining confessions, but one thing is evident from the vast literature on the matter: this evidentiary mechanism is currently overused, much beyond the optimal level. The reasons for this over-use are varied, among them the fact that confessions are readily available for law enforcement officers, and that those in charge of trying the facts tend to overwhelmingly convict based on out-of-court confessions, while underestimating the associated dangers. As a result, confessions have come to play a paramount role in the criminal justice system. Many attempts have been made to deal with confession-based wrongful convictions. Examples include the Miranda rules or the requirements for varying degrees and types of corroborating evidence. To date, all the rules and proposals share a common characteristic: They all attempt to correct the evidentiary fallacies associated with out-of-court confessions by evidentiary means, whether admissibility oriented or weight oriented. In the article we argue that none of the proposed mechanisms is likely to solve the problem. The root of the problem lies in the fact that the entire criminal justice system is currently organized around confessions. Law enforcement officers focus on obtaining confessions and the prosecution uses it as its evidentiary centerpiece. Further restricting admissibility or requiring a higher degree of corroboration will not change this trend. Moreover, the confessional lure is too strong to resist. Like the Sirens' Song, the confession casts a spell on all those subjected to it and, no matter how strong a corroboration we require, we will eventually fall back on the confession. We propose an entirely different solution to the tendency to over-use confessions, one that utilizes penal means to change the incentive structure within the criminal justice system. We propose to incorporate into the sentencing guidelines a mandatory reduction of the criminal sanction whenever an out-of-court confession is introduced into evidence by the prosecution. In other words, our proposal is to elevate the cost of using out-of court confessions, as compared to other types of evidence. The article will demonstrate how placing such a "sentencing price tag" on the use of out-of-court confessions will correct the current bias in favor of using this evidence and induce law enforcement officials to seek extrinsic evidence, thus turning confessions into a residual evidentiary devise. The article will also show that the proposed regime will improve the court's ability to distinguish between true and false confessions. After discussing the proposed model's normative appeal, the article will proceed to deal with possible criticisms which can be leveled against it, whether retributive, utilitarian or expressive. (shrink)

has been put forth by Rolston, which leads to respect for the irreversibly comatose by virtue of the residual biological (objective) life. By comparing objective and subjective life, he develops a naturalistic principle which he contrasts with the humanistic norm of contemporary medical ethics. He claims there are clinical applications which would necessarily follow. A critique of this viewpoint is presented here, which begins with an analysis of what might be of value in spontaneous objective life. A measure of (...) the moral worth of simple objective life is attempted by means of comparison with our attitudes toward animals. Finally, some of the clinical applications suggested by Rolston are reviewed. Except for euthanasia, there appear to be few clinical situations where the naturalistic principle helps in problem solving. Keywords: naturalistic principle, value of life, irreversibly comatose CiteULike Connotea Del.icio.us What's this? (shrink)

The endoplasmic reticulum (ER) uses various mechanisms to ensure that only properly folded proteins enter the secretory pathway. For proteins that oligomerize in the ER, the proper tertiary and quaternary structures must be achieved before their release. Although some proteins fold before oligomerization, others initiate oligomerization cotranslationally. Here, we discuss these different strategies and some of the unique problems they present for the ER quality control system. One mechanism used by the ER is thiol retention. Thiol retention operates by monitoring (...) the redox state of specific cysteine residue(s) and was discovered in studies on the assembly of IgM, a complex oligomeric glycoprotein. This system is also involved in retaining other unassembled proteins in the ER. Mutations that result in uneven numbers of cysteine residues can subject yet other proteins to thiol retention, altering their oligomerization status and function. The implications of these results on the effects of thiol retention on protein function and cell fate are discussed. BioEssays 20:546–554, 1998. © 1998 John Wiley & Sons Inc. (shrink)

En el presente artículo se analizan cinco modos de entender el ideal de completitud de los sistemas jurídicos, teniendo como punto de referencia las ideas de Carlos Alchourrón. En este trabajo se propone distinguir los criterios de identificación de los textos jurídicamente relevantes; los métodos o reglas que permiten pasar de un contenido C a un contenido C1, y los criterios de validez o pertenencia de normas al sistema. En la concepción predominante entre los teóricos del derecho, las reglas lógicas (...) sirven para justificar el paso de un contenido a otro, sin embargo, no se admiten como criterios de pertenencia de normas al sistema jurídico. Esto significa que el derecho no es concebido como un sistema deductivo y que un ideal de completitud absoluta es lógicamente posible. En el trabajo se llega a la conclusión de que hay sólo dos formas no banales de entender el ideal de completitud absoluta de los sistemas jurídicos. O bien, en un espíritu formalista, mediante la introducción de reglas residuales de clausura o bien, en un espíritu moralista, aceptando que la moral crítica funcione como criterio de pertenencia al derecho. This paper analyses five different ways of understanding completeness as an ideal of legal systems. In doing so it essentially relies on the thesis discussed by Carlos Alchourrón regarding this subject. The paper stresses the need to distinguish the criteria for the identification of the legally relevant texts, the methods or rules that justify the passage from a content C to another content C1 and, the criteria for the identification of valid norms belonging to the system. According to the dominant conception in legal theory, the rules of logic justify the passage from a content to another; such rules, however, are not accepted as membership criteria. This means that the notion of system that legal theorists use to organize the law is not the notion of a deductive system. In this conception the ideal of absolute completeness is a logically possible ideal. The conclusion reached in the article is that there are only two ways of understanding the ideal of "plenitude" or absolute completeness of a legal system: in a formalist view, through the introduction of residual rules of closure, or, in a moralistic view, by accepting critical morality as a criterium for legal validity. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:THE LETHAL NARCISSUS: HEIDEGGER ON SACRIFICE/SACRIFICE ON HEIDEGGER Stefano Cochetti Technische Universität Chemnitz-Zwickau At the end oíJargon ofAuthenticity? the biting irony ofAdorno's critique reaches the level of indignation on two occasions; both ofdiese occasions concern the topic of sacrifice. This indignation is easy to explain ifone considers tiie principal aspects ofthe Adornian theory of sacrifice as formulated in Dialectic ofthe Enlightenment} According to Adorno, sacrifice assumes a modern rational (...) value when it emerges as the secularization ofritual sacrifice along two lines of evolution: 1) the intrasubjective and 2) the inter-subjective. 1)Ritual sacrifice evolves into internalized sacrifice in the form of individual renouncement and self-discipline, namely as the intra-subjective modality withstanding the temptation of reverting to indifferentiation as die undifferentiating subordination of the ego to its instincts. The Sirens epitomize this threat. That is why they are Ulysses' enemies. 2)Ritual sacrifice is, however, also secularized in inter-subjective terms, insofar as it is transformed—according to Adorno—into rational exchange, that is, it changes from metaphysical exchange with divine entities into physical exchange of objects among human beings alone. 1 T. W. Adorno,Jargon derEigentlichkeit. Zur deutschen Ideologie (130, 132-133). 2 Horkheimer & T. W. Adorno, Dialektik derAufklärungi50-%1); Cochetti,Mythos und "Dialektik derAufklärung" (181-186). 88Stefano Cochetti Adorno's indignation towards Heidegger arises from the fact that Heidegger highlights in positive terms precisely the residual mythical aspects of secularized sacrifice, and not the rational ones. Intrasubjectively, self-discipline as the sacrificial ability of the individual to resist and renounce urges entails a rational value insofar as it is functional for the self-preservation of both the individual and the community. Now, Heidegger does not even consider this aspect of sacrifice. Instead, he esteems endurance in the face of Worry (Sorge) in itself as Being-for-death (Sein-zum-Tode). In Adorno's view, this implies the eventual yet cogent consequence that the endurance ofpain in itselfduring the agony which precedes death would evolve into the most authentic moment oíDasein. This is precisely the mythical-ritual residue which has passed through the filter of secularization and which still reverberates with the original blood-practices of initiation rites and ritual torture. Analogously, on the inter-subjective level, Heidegger judges the exchange aspect ofsecularized sacrifice—the sacrifice of an individual for his community or cause—to be a negative value. Consideration of the reasons, the specific ends, and the gains and losses of such a sacrifice is precisely what ought to be forgotten if the sacrifice in question is to have any value. Adorno's indignation is easily explicable when one considers two contexts: (i) the anthropological-evolutionary, and (ii) the historicalpolitical. (i) In the first context, the death of the individual in the service of a particular cause, which is not subject to a priori rational scrutiny, still retains an echo of an irrational predetermination which is mythicalritualistic in nature. (ii) The second context is Nazi Germany. In the face ofthis background, even Heidegger is, in this respect, unable to argue in defense of specific Nazi ideals beyond the generic need to simply pursue the collective survival of the nation at war. Paradox and dilemma of death It is this inability to produce an argument that opens a way for the primacy of sacrifice for its own sake: a sacrifice being unaware of any calculation ofgain and loss which might not only lessen its intrinsic value, but also its very performance. The most interesting aspects of Heidegger's attitude towards sacrifice should not, however, be considered on the basis The Lethal Narcissus89 of its pitiful political implications, which cannot be amended, but rather on the basis of the theoretical and historically symptomatic character of his examination of death. In this respect, I believe that the Girardian mimetic theory affords decisive clues for a coherent interpretation. In the chapter entitled "The Possible Completeness of Dasein and Being-for-deatJi" (Das mögliche Ganzsein des Daseins und das Sein zum Tode) in Being and Time, Heidegger considers the paradox of death: As soon as Dasein, however, "exists" in such a way that simply nothing of it is missing, it has already become one... (shrink)

Dogs are known for their incredible ability to detect odours, extracting them from a “complex” environment and recognising them. This makes sniffer dogs precious assets in a broad variety of security applications. However, their use is subject to some intrinsic restrictions. Dogs can only be trained to a limited set of applications, get tired after a relatively short period, and thus require a high turnover. This has sparked a drive over the past decade to develop artificial sniffer devices—generally known (...) as “chemical sniffers” or “electronic noses”—able to complement and possibly replace dogs for some security applications. Such devices have been already deployed, or are intended to be deployed, at borders, airports and other critical installation security checkpoints. Similarly to dogs, they are adopted for detecting residual traces that indicate either the presence of, or recent contact with, substances like drugs and explosives. It goes without saying that, as with sniffer dogs, the use of artificial sniffer devices raises many sensitive issues. Adopting an ethical and legal perspective, the present paper discusses the privacy and data protection implications of the possible deployment of a hand-held body scanning sniffer for screening passengers at EU airport security checkpoints. (shrink)

The European Union’s funding of electricity made of biogas that is obtained from purpose-grown plants accelerated the global boom of renewable energy two decades ago. Tens of thousands of biogas plants were built in EU farms soon after. As this specific trend toward renewable energy globally spreads, it has the potential to alter the features of agriculture in the future. Such conceptual changes are related to a variety of socio-economic and environmental implications that manifest itself over a large time scale. (...) Regarding renewables made of purpose-grown plants, a majority of reservations are related to its production economy, particularly since these biofuels are expected to compete with food or feed. So far, little attention has been paid to the fact that the fields of farms that run biogas stations are subject to shortly repeated erosive crops followed by the intensive application of the fermentation residues obtained. The various types of soil on different European farms, which have been operating biogas stations for at least two decades, were analyzed. It was revealed for the first time that such practices cause soil degradation and pose a threat to food production, which has been overlooked until now. The relations between ethical and economical points of view are discussed. (shrink)

The possible Stoic origins of the natural rights and natural law theories of the Dutch jurist Hugo Grotius (1583–1645) has been a subject of scholarly debate in recent years. Yet discussions about Grotian sociability tend to focus exclusively on the meaning of appetitus societatis in De Jure Praedae (written in 1604–1608) and De Jure Belli ac Pacis (1625), with little reference to the historical context. Insufficient consideration has been given to the intended audience(s) of these works, Grotius’ purpose in (...) writing them, and the possible correlation between his overarching argument and his working methods. This article examines Grotius’ use and abuse of Seneca's philosophical works in De Jure Praedae, commissioned by the directors of the Dutch East India Company (or VOC) in autumn 1604. The brutal murder of Sebald de Weert on the island of Ceylon (modern-day Sri Lanka) in June 1603 is analyzed from a Stoic perspective in Chapter 15 of De Jure Praedae. Following his refusal to hand over Portuguese prisoners, De Weert and his crew were butchered on the beach of Batticaloa by Wilama Dharma Suriya, the ruler of the island's interior. Grotius blamed the victim. VOC commanders in monsoon Asia should suppress any residual loyalty which they might feel towards Christendom. It was imperative to conclude alliances with native rulers against the Iberian colonial powers, regardless of the rulers’ (lack of) faith or their horrific treatment of prisoners. As Grotius noted in Chapter 8 of De Jure Praedae, Seneca distinguished between “two kinds of commonwealth, the world state and the city state.” Spanish and Portuguese violations of the natural law – freedom of trade and navigation in particular – deserved condign punishment for the sake of both the fellowship of mankind and, naturally, the VOC and Dutch Republic. In assessing the uses of Stoicism in De Jure Praedae, much can be learned from the physical characteristics of Ms. BPL 917 in Leiden University Library, its sole surviving manuscript copy. Seneca's philosophical works are not cited at all in the original text of Ms. BPL 917, which Grotius copied out in 1604–1605. Instead, quotations from De Ira, De Clementia and De Beneficiis appear in the top and bottom margins of folio-pages or on inserted sheets of paper, which can be dated to 1607–1608. These quotations serve to flesh out an existing argument about the VOC's just war(s) in the East Indies. A case in point is the heavily rewritten Chapter 2. Grotius added quotations from De Clementia at the same time as he reformulated two natural laws on f. 8–9, a folio sheet inserted in or after January 1607. This was no coincidence. Revenging the past misdeeds of the Portuguese, which Grotius had described in great detail in Chapter 11, could no longer be considered the main or only priority of the VOC. Instead, Grotius contended on f. 8–9 that “evil deeds must be corrected” so as to achieve, in Seneca's words, “universal security.” Acting as a kind of global police force, the VOC should punish transgressors of the natural law on account of “that world community” envisioned by the Stoics. The practical consequences were felt during the Twelve Years Truce (1609–1621). Despite a cessation of arms in Europe, the VOC continued to engage in hostilities in the East Indies. The author of De Jure Praedae supported the Company on this. Like Cicero before him, he had successfully harnessed the Stoa to the cause of empire. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:The Place of Touch in the ArtsChristopher Perricone (bio)IntroductionIn Breughel's great picture, The Kermess, the dancers go round, they go round and around, the squeal and the blare and the tweedle of bagpipes, a bugle and fiddles tipping their bellies (round as the thick- sided glasses whose wash they impound) their hips and their bellies off balance to turn them. Kicking and rolling about the Fair Grounds, swinging their (...) butts, those shanks must be sound to bear up under such rollicking measures, prance as they dance In Breughel's great picture, The Kermess.1"The Dance" written by William Carlos Williams in 1944 is one of my favorites. Williams gives us a feel for that life of the kermess (a carnival) in his poem through Breughel's picture, as it were three times removed from the event itself. Of course, unlike Plato, I would argue that the vitality of the kermess is not lost in the poem; it is actually enhanced by a subtle sleight of hand. The poem is not primarily about Breughel's picture. It is about dance, about the dancers who go round, their squeal, the crude music, its rollicking measures, the dancers kicking and rolling and swinging, their hips, bellies, and butts. Reading this poem, I "see" those ordinary folk of Breughel's great picture. I "hear" their music. I "move" to their dance. The poem seems a condensation, a summary of the fine arts. Perhaps the poem is about poetry's power to reinvigorate imaginatively what we hear and see. Perhaps I think of festivities at which I have danced, how such festivities are essential to the human experience. Perhaps William Carlos Williams in 1944, World War II coming to a close, was anticipating similar good times.Tactile ValuesThe fine arts do much to educate our senses. One need only recall the many essays and books written on art, on how to look and hear, how various [End Page 90] critics draw our attention to the power of imagery and song. The well-formed visual and auditory sensations we gain from the arts are, as it were, the melody of those experiences. They are the pictures we store away, the tunes we whistle. However, here I want to draw attention to an overlooked sense—touch. I want to argue that touch is the bass line to the melody of sight and hearing in the arts, that is, that touch keeps the artwork coherent and grounded.This is an old idea. Bernhard Berenson had the idea when he was examining the painters of the Italian Renaissance. In a sense this article is a resurrection of Berenson's idea of "tactile values." Berenson was on to something both about painting and about the arts in general. However, he lacked the scientific evidence about touch and its role in human relationships needed to develop his idea of tactile values to any great extent.The idea of tactile values is first mentioned at the beginning of the essay "The Florentine Painters." Berenson is discussing the art of Giotto. However, prior to plunging into his subject, he says that we need to know what is essential to figure painting before we can appreciate its real value. What is essential are the "tactile values" we give to our retinal impressions, "a test of reality."2 Painting stimulates touch in order for it to stimulate our "tactile imagination."3 Giotto was a genius in stimulating the tactile imagination. Like other medieval masters, Giotto was a fine story teller and had great compositional skills. However, unlike Giotto, other medieval masters "never painted a figure which has artistic existence."4 Giotto's predecessors crafted "highly elaborate, very intelligible symbols, capable, indeed, of communicating something, but losing all higher value the moment the message is delivered."5 If such medieval symbols communicated anything at all, it was only some residue of what one might touch; whatever reality those symbols might have possessed was virtually eviscerated by the artists' emphasis on form and cognitive content. Giotto's predecessors were driven merely by ideas and, one might add, not altogether consistent and coherent ones. On the contrary, Giotto's work seemed to... (shrink)

El presente trabajo analiza el libro Guión de Héctor Hernández Montecinos desde las perspectivas de flujo y de profanación para dar a conocer un tipo de producción poética que tensiona un problema del lenguaje: si el lenguaje es o no una representación de un sujeto que se asume en la escritura. Para este caso se postula que el sujeto que habla no se representa en el lenguaje. Lo que hay en esta lectura son solo residuos o devenires ficcionales de un (...) posible sujeto que se profana en el lenguaje. Por lo anterior, este lenguaje poético está expuesto como delirios mentales para hablar sobre poesía, historia y modos de entender la realidad. This paper analyzes Guión from the perspectives of flow and defilement to provide a kind of poetic production that stresses a problem of language: if the language is or is not a representation of a subject that is assumed in writing. For this case, it is postulated that the speaking subject is not represented in the language. What is in this reading are only residuals, or fictional becomings of a possible subject that is profaned in language. Therefore, this poetic language is exposed as mental delusions to speak about poetry, history and ways of understanding reality. (shrink)

The experience of family harmony, as an individual's subjective evaluation of harmonious family relations, has an important influence on the development of their physical and mental health. This study aimed to develop the College Students' Experience of Family Harmony Questionnaire that is fit for college students in China. On the basis of literature analysis and survey with questionnaires, five pairs of opposite assessment indexes were constructed in this paper, namely, Atmosphere of family, Responsibility to housework, Time-sharing, Seeking help, and Supporting (...) family members. Items of this questionnaire were collected from investigation, relevant scales, and discussion with experts. Here, 562 college students were selected for the pre-test and 696 for the formal test. The results showed that, except for the dimension of refusing housework, which has been deleted, other dimensions remain unchanged, and the final nine dimensions accounted for 66.03% of variance variation. Furthermore, the result of confirmatory factor analysis indicates that the model fit well with the data in construct validity [χ2/df = 2.71, Incremental Fit Index = 0.90, Tucker–Lewis Index = 0.89, Comparative Fit Index = 0.90, root mean square error of approximation = 0.05, standardized root mean square residual = 0.05]. The Cronbach's alpha coefficient of this questionnaire was 0.97. The split-half reliability was 0.92, and the test–retest reliability was 0.75 for the total questionnaire. The total score of the questionnaire was significantly positively correlated with the total score of family function, family cohesion, family adaptability, and well-being, and it had a significant negative correlation with loneliness. The results showed that the final structure was reasonable, and reliability and validity conformed to the requirements of psychometrics. Therefore, the questionnaire developed in this study can be used as a valid instrument for assessing the experience of family harmony among college students in China. (shrink)

Theorists are converging from quite different quarters on a version of the global neuronal workspace model of consciousness, but there are residual confusions to be dissolved. In particular, theorists must resist the temptation to see global accessibility as the cause of consciousness (as if consciousness were some other, further condition); rather, it is consciousness. A useful metaphor for keeping this elusive idea in focus is that consciousness is rather like fame in the brain. It is not a privileged medium (...) of representation, or an added property some states have; it is the very mutual accessibility that gives some informational states the powers that come with a subject's consciousness of that information. Like fame, consciousness is not a momentary condition, or a purely dispositional state, but rather a matter of actual influence over time. Theorists who take on the task of accounting for the aftermath that is critical for consciousness often appear to be leaving out the Subject of consciousness, when in fact they are providing an analysis of the Subject, a necessary component in any serious theory of consciousness. (shrink)

Philosophical reflection proposes a return to self as the condition required of a genuinely radical transcendental philosophy. This proposal has its proper ground. It is not an ideal externally imposed upon reflection but rather springs from the very structure of reflection itself in its relation to the reflected. It has its source, specifically, in the capacity on the part of reflection to gain mastery over any proposed external condition in the sense that the very posing of such a condition, presumed (...) to mark the limit of reflection, proves, in the end, to be itself the work of reflection. To the extent that reflection, as re-enactment, poses the limit for itself, it thereby represents the limit in such fashion as to exhibit it as having already been, at the unreflected level, no more than a constitutive product. To the degree that reflection brings an external limit to light, it reveals that limit as sustained precisely by the light which illuminates it, and hence, it dissolves its externality. Thus, philosophical reflection proposes a return to self which is achieved in an act of total reflection. Such reflection first opens up the domain of philosophical thought by actualizing at a single stroke the ideal born of the first act of reflection. It places itself from the very outset at the terminal point of the transcendence from perspectivity to objectivity whose inherent incompleteness defines our perceptual life, and it claims not only to have achieved this vantage point but also to have brought objectivity totally under its command, to have subjugated it by elevating itself to that position which is no longer really a position at all, that position from which objectivity is only for-consciousness. The return to self is a reflective appropriation of the pre-reflective through which the identity of reflection with the reflected is established in such a way that all that remains to be accomplished is the explication by reflection of what is already totally, though still implicitly, appropriated to it. The authentic task of philosophical thought is to render the implicit explicit. Transcendental philosophy is thus obliged to insist that with the very inception of genuinely philosophical thought the subject is already implicitly a pure presence of itself to itself, a presence which is, in principle, totally transparent. The subject is pure inferiority, and the way is prepared for asserting, with Hegel, that “Spirit is Being-within-itself.” Even its own return to itself by which it first reaches the level of philosophical thought is, in the end, taken up into the circuit of self-presence definitive of this level and appropriated in such a fashion that the shadows which made this path of self-discovery into a highway of despair are banished by the high noon of reflection; the subject's own constitutive history is transformed without residue into a history constituted by the subject. (shrink)

“One man’s ceiling is another man’s floor”Paul SimonThe words of Paul Simon capture the essence of what the courts are called upon to deal with when adjudicating matters of health. Wealthier and healthier neighbors living in the upstairs apartment are, all things being equal, not overly interested in raising the floor of their apartment in order to create more space for those in the apartment below. The floor is tangible, measurable and movable, and thus a subject where science can (...) contribute much. However, where to locate the floor is a matter of values and thus largely in the realm of politics.Resorting to the courts in matters of public policy can be seen as the residual of the inability of the remaining two branches of government, the legislature and the executive, to succeed in allocating resources and regulating the system. When the combination of science and politics falters, enter the judiciary. (shrink)