This chapter contains sections titled: Introduction Values Micro‐organisms and Plants Animals Humans Patents References.

Inflammation is said to be a healthy component of the body's immune system's reaction. Inflammation is characterised by four key symptoms: pain, redness, heat or warmth and swelling. As secondary metabolites, plants may produce a wide range of phytochemical compounds, which possess anti-inflammatory characteristics. Herbal remedies are important therapies for a wide range of ailments all over the world. There are around 7,500 species of medicinal plants, including representatives from over 17,000 flowering plant species. Even though synthetic chemistry (...) has developed its expectations, the use of natural ingredients in the manufacture of drugs used in contemporary medicine is unparalleled. By interfering with the biology of inflammation, anti-inflammatory medications may assist to minimising tissue damage and increase patient comfort. Because of the bulky figure of species reachable for study, the effective development of novel naturally taking place anti-inflammatory drugs is mostly dependent on a multidisciplinary approach to discovering new chemicals. Despite the statistic that many review papers have been produced in this field, the conventional of them simply examined the issue from an area perspective. Several non-steroidal anti-inflammatory drugs have been shown to reduce inflammation and pain by decreasing the isoform of the cyclooxygenase enzyme's digestion of arachidonic acid, hence lowering prostaglandin production. Non-steroidal anti-inflammatory drugs have a host of harmful effects. There are, however, medicinal herbs with anti-inflammatory pharmacological properties that have few or no negative effects. (shrink)

The Mycobacterium Tuberculosis complex is a group of species of Mycobacteria involved in a serious bacterial disease which infects the respiratory system and organs. Multi-drug resistant (MDR) strains have been produced as a result of the fast emergence of resistance against first-line anti-tuberculosis medicines in recent years worldwide. The objective of this study is to determine alternatives to anti-mycobacterial antibiotics, such as Manuka honey and Indian costus. MTB isolates (???? = 15) were evaluated for their susceptibility to Manuka honey (...) graded as +15 and Indian costus by using different concentrations. Among the TB isolates (???? = 15) tested, four (27%) isolates were resistant at 15% v/v honey, while, at 18% v/v of Manuka honey, two (13%) isolates were found to be resistant. Resistance was not seen at honey concentrations of 20% v/v. On the other hand, Indian costus had a slight effectiveness at concentrations of 20% and 25%, affecting only two and five isolates of Mycobacteria, respectively; however, all isolates were inhibited at a concentration of 33% v/v of Indian costus. The present study clearly demonstrates that supposed alternatives (Manuka honey graded as +15 and Indian costus) possess significant anti-mycobacterial activity in vitro; however, further clinical trials should be performed to corroborate our initial findings. (shrink)

This paper will begin with some very broad and general considerations about the kind of biological entities we are. This exercise is motivated by the belief that the view of what we—multicellular eukaryotic organisms—are that is widely assumed by biologists, medical scientists and the general public, is an extremely limited one. It cannot be assumed a priori that a more sophisticated view will make a major difference to the science or practice of medicine, and there are areas of (...) class='Hi'>medicine to which it is probably largely irrelevant. However, in this case there are important implications for medicine, or so I shall argue. In particular, it enables us to appreciate fully the potential medical significance of some of the most exciting contemporary advances in general biology, in such fields as epigenetics, metagenomics, and systems biology; and part of this significance is that these advances have raised serious doubts about how we should understand the biological individuals that medicine is generally assumed to aim to treat. (shrink)

This essay draws a new picture of the science of bacteria in its 'golden age', circa 1880-1900: the organization of its knowledge and practice, its germ theory of disease, the difference between its two major research traditions, and, above all, its place in life science in this period that bristled with theories and debates over inheritance, variation, selection, evolution and that witnessed the transition from natural history to laboratory biology. Pasteur and Koch's science acquired this biological dimension not despite (...) being outside academic biology, nor despite the limitations of its applied, medical matrix, but rather because of that framework. The very practices of vaccine development constituted, at the same time, a new biological model of bacterial species and variation, which aligned them with other living things. Finally, the new picture reveals unsuspected continuity to later microbiology and molecular biology. In illuminating the self-perceptions of these sciences in relation to the past, it situates and opens a critical perspecive on writings by bacteriologists such as Ludwik Fleck, François Jacob and René Dubos, which have widely informed how we understand science. (shrink)

Although it is now generally acknowledged that new biomedical technologies often produce new definitions and sometimes even new concepts of disease, this observation is rarely used in research that anticipates potential ethical issues in emerging technologies. This article argues that it is useful to start with an analysis of implied concepts of disease when anticipating ethical issues of biomedical technologies. It shows, moreover, that it is possible to do so at an early stage, i.e. when a technology is only just (...) emerging. The specific case analysed here is that of ‘molecular medicine’. This group of emerging technologies combines a ‘cascade model’ of disease processes with a ‘personal pattern’ model of bodily functioning. Whereas the ethical implications of the first are partly familiar from earlier—albeit controversial—forms of preventive and predictive medicine, those of the second are quite novel and potentially far-reaching. (shrink)

Recently, a friend of one of these writers told her story of using one of a healthcare product to activate her stem cells as part of regenerative medicine. Regenerative medicine is a field of medicine that seeks to repair or replace damaged or diseased tissues and organs. This can be done through a variety of methods, including stem cell therapy, tissue engineering, and gene therapy. This is a short review article on this rapid field called regenerative (...) class='Hi'>medicine, in particular via a new method called photobiomodulation, especially by virtue of low-intensity laser pen treatment. Hopefully it will attract more research in this interesting direction, both for laser/photobiomodulation to boost plant growth as well as in healthcare (see also: Christianto & Smarandache, 2022; Christianto, 2023). (shrink)

The Science and Religion Forum (SRF) seeks to be the premier organization promoting the discussion between science and religion in the United Kingdom. Each year, the SRF holds a conference tackling a topical issue, and in 2017 focused on mental well‐being, neuroscience, and religion. This article introduces the thematic section which is made up of five papers from that conference. As a new field within the science and religion academy, these articles are both wide‐ranging and detailed. This introductory article locates (...) this section within the academy and argues that its place is not only valid but vital, given the increase of mental health problems and the need for medicine, church, and society to answer this problem and present ways to help. (shrink)

According to policy makers, telemedicine offers “huge opportunities to improve the quality and accessibility of health services.” It is defined as diagnosis, treatment, and monitoring, with doctors and patients separated by space but mediated through information and communication technologies. This mediation is explored through an ethnography of a U.K. teledermatology clinic. Diagnostic image transfer enables medicine at a distance, as patients are removed from knowledge generation by concentrating their identities into images. Yet that form of identity allows images and (...) the expert gaze to be brought into potentially lifesaving proximity. Following Latour’s thread, images must be captured and then mobilized to the knowledge base, where they must be stabilized into standard diagnoses, then combined with different images, waiting lists, skin lesions, dermatologists, paper records, and beds, so that ultimately, outcomes are produced. This huge task requires new knowledges and a widening of agency that, if unacknowledged, may see telemedicine projects continue to founder. (shrink)

The aim of this study is to investigate radio frequency identification tagging as a form of sociotechnical experimentation and the kinds of sociotechnical futures at stake in this experimentation. For this purpose, a detailed analysis of a publicly available promotional video by a tag producer for the fashion industry, a sector widely using RFID tags, was analysed in detail. The results of the study indicated that the sociotechnical imaginary of RFID tagging gravitates around the core value of perfect sociotechnical efficiency. (...) This demands a high degree of readiness to engage in standardization efforts, which performs a specific materialized understanding of ethics by other means. Furthermore, the analysis points to the importance of considering the spatiotemporal dimensions in which RFID tags work when reflecting on how this technology matters to society. Finally, the analysis shows a tacit effort to keep RFID technology and thus any questions of responsible innovation confined to the shop floor. However, given the spreading of the use of RFIDs, much wider-ranging considerations are called for. (shrink)

Historians and cultural critics face special challenges when treating the nonhuman natural world in the medieval and early modern periods. Their most daunting problem is that in both the visual and written records of the time, nature seems to be both everywhere and nowhere. In the broadest sense, nature was everywhere, for it was vital to human survival. Agriculture, animal husbandry, medicine, and the patterns of human settlement all have their basis in natural settings. Humans also marked personal, community, (...) and seasonal events by natural occurrences and built their cultural explanations around the workings of nature, which formed the unspoken backdrop for every historical event and document of the time. Yet in spite of the ubiquity of nature's continual presence in the physical surroundings and the artistic and literary cultures of these periods, overt discussion of nature is often hard to find. Until the sixteenth century, responses to nature were quite often recorded only in the course of investigating other subjects. In a very real sense, nature went without saying. As a result, modern scholars analyzing the concept of nature in the history of medieval and early modern Europe must often work in deeply interdisciplinary ways. This challenge is deftly handled by the contributors to Engaging with Nature, whose essays provide insights into such topics as concepts of animal/human relationships; environmental and ecological history; medieval hunting; early modern collections of natural objects; the relationship of religion and nature; the rise of science; and the artistic representations of exotic plants and animals produced by Europeans encountering the New World. "As scholars of medieval and early modern Europe increasingly embrace environmental perspectives and animal studies, Engaging with Nature will be recognized as a landmark collection in the field. Taken together, the essays in this volume provide a synthetic overview of critical developments in the many disciplines that are now incorporating the approaches of natural and environmental studies. Each essay represents a substantial advance in scholarship and thought in its particular field. This is an essential collection for literary and cultural historians, and for historians of economy and society, art and ideas." --Rita Copeland, University of Pennsylvania "Engaging with Nature vividly captures the breadth and depth of human interactions with the natural world in premodern Europe. Its multidisciplinary approach generates new questions about how Europeans understood and connected with nature and delves into issues that will interest the specialist and the general reader alike. The book challenges readers to rethink not just the history of human engagement with nature but also the many ways the past has influenced our modern conceptions of ecology and environment." --James Masschaele, Rutgers University "This substantial collection of articles is far more than a response to current obsessions with climate change. It is a thought-provoking demonstration of the inter-disciplinary character of research on medieval history and culture. Students of medieval and early-modern society and economy, literature, philosophy, and art, will find much that is new in these essays, and much to provoke their own thinking about the vexed relationship of human societies with their natural surroundings." --Fredric Cheyette, Emeritus professor of history, Amherst College "Engaging with Nature is a deeply pleasurable volume to read. Using an incredible range of primary and secondary sources, the authors richly realize the methodological promise inherent in the emergent field of medieval and pre-modern studies on the history of nature." --Kathleen Biddick, Temple University "Engaging with Nature is a collection of impeccable scholarship that will make a highly original contribution to the emergent field of medieval and pre-modern studies on the history of nature." --Claire Sponsler, University of Iowa. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:The Intersection of Medicine and ReligionJohn C. DormoisThe practice of medicine offers a host of rewards to the practitioner. Besides the obvious intellectual satisfaction of solving a difficult diagnostic problem or the ability to make a comfortable living, I have found the greatest personal sense of moral gratification when helping [End Page 196] families negotiate the most challenging event in life: making decisions at end of life. (...) Whether the condition was a ruptured intracranial aneurysm with brain death or a patient with far advanced cancer struggling with the choice between experimental chemotherapy or choosing comfort therapy at home surrounded by family for the remaining days of life, the moral courage required to provide the best guidance was considerable. In my early years of practice I didn’t call my actions in these situations “courageous” nor were there moral “guidelines” providing a blueprint. I knew I responded with empathy and compassion and that this ability had a lot to do with being raised in a religious or spiritual home. At the same time, I suspected that some of the lack of empathy and compassion I witnessed in some of my colleagues was related to the very training programs of physicians. This essay traces the origin of my moral and ethical concerns about medical education and my intention to reinvigorate the spiritual or existential voice in medicine.An early life experience had a great deal to do with shaping my moral development. At age seven my family traveled through the West Indies. My father’s amateur radio hobby meant that at every stop we would be greeted by one of his radio contacts. One stop in particular was life changing.Port au Prince, Haiti was an unknown place to this seven year–old, but to say it was a culture shock to a boy from Kansas would be an understatement of epic proportions. It was during this visit that I experienced true poverty in its most blatant form. In downtown Port au Prince I saw limbless beggars and the deformed from polio and malnutrition. But it was the sight of the garbage dump near the center of town that changed my world forever. There, among piles of detritus, I saw children and families making their home in the dump. They had hollowed out a sort of cavern in the piles of trash that served as a place of refuge from both the rain and the sun.This experience in many ways has served as a framework and background for my life. Although seen through the eyes of a seven year–old, the picture can only be adequately understood within the context of being raised by religiously faithful parents, parents free of hypocrisy whose lives personified the best in Christian virtues and practices. These early experiences planted the seeds that would only fully blossom some 60 years later.Medical school was a demanding but exhilarating experience. Each day was a day of discovery … anatomy, physiology, pathology … all subjects opening up a whole new world to explore. Internal medicine suited me best since it was the specialty that most closely integrated all the basic sciences necessary to arrive at a diagnosis. I loved the elegance of endocrinology in particular where a given hormone mediator could cause widely different effects if present in excess or completely absent. But I was in the end drawn to cardiology since it combined complex physiology with my avocation, the love of running.There was, however, a disturbing aspect of medicine education that I observed affecting many of my classmates. Although I can vividly recall the enthusiasm that all of us shared as we donned our white coats for the first time and envisioned a future of caring for our patients, things gradually and insidiously changed over the next four years. The altruism and empathy that was so evident in the early years gradually lessened as graduation approached. I could not help being struck by this change and wondered at the time why that should happen. I had no insight then that what I had observed was a well recognized consequence of the medical school experience. I’m sure that the passage from professional training to practice in... (shrink)

One of the most dynamic areas of plant molecular biology is the investigation of the actions of three classes of herbicides: s‐triazines (atrazine, simazine), glyphosate, and sulfonylureas (chlorsulfuron, sulfometuron methyl) (Figure 1). The results of this work are expected to provide the first significant applications of plant biotechnology: directly, in the genetic engineering of crop plants resistant to specific herbicides and, indirectly, in providing a molecular basis for the rational design of new herbicides for specific biological targets.s‐Triazines affect photosynthesis (...) by inhibiting the binding of quinones to the chloroplast membrane QB protein. An s‐triazine resistant QB protein isolated from weeds in fields consistently treated with the herbicide has a serine in place of a glycine in this highly conserved protein. Glyphosate inhibits 5‐enolpyruvyl‐shikimate‐3‐phosphate synthase (EPSP synthase), an enzyme in the aromatic amino acid biosynthetic pathway. Mutagenized bacteria produce a resistant EPSP synthase with a substitution of serine for proline. Sulfonylureas inhibit the acetolactate synthase (ALS) of bacteria, yeast, and higher plants; this enzyme catalyzes the first step in the synthesis of branched chain amino acids. Resistant ALS has been found in bacteria, yeast and tobacco with a proline substituted by serine in yeast ALS. These findings provide a strong basis for developing projected plant biotechnology applications. (shrink)

Precision Medicine has become a common label for data-intensive and patient-driven biomedical research. Its intended future is reflected in endeavours such as the Precision Medicine Initiative in the USA. This article addresses the question whether it is possible to discern a new ‘medical cosmology’ in Precision Medicine, a concept that was developed by Nicholas Jewson to describe comprehensive transformations involving various dimensions of biomedical knowledge and practice, such as vocabularies, the roles of patients and physicians and the (...) conceptualisation of disease. Subsequently, I will elaborate my assessment of the features of Precision Medicine with the help of Michel Foucault, by exploring how precision medicine involves a transformation along three axes: the axis of biomedical knowledge, of biomedical power and of the patient as a self. Patients are encouraged to become the managers of their own health status, while the medical domain is reframed as a data-sharing community, characterised by changing power relationships between providers and patients, producers and consumers. While the emerging Precision Medicine cosmology may surpass existing knowledge frameworks; it obscures previous traditions and reduces research-subjects to mere data. This in turn, means that the individual is both subjected to the neoliberal demand to share personal information, and at the same time has acquired the positive ‘right’ to become a member of the data-sharing community. The subject has to constantly negotiate the meaning of his or her data, which can either enable self-expression, or function as a commanding Superego. (shrink)

Innovation is fundamental to the pharmaceutical industry and a key to improvements in healthcare. Its effectiveness depends on huge, constant investments in research. This innovative industry directly affects the course of studies in healthcare and medicine. Its efforts translate directly into the length and quality of our lives. For several years now, the progress underway in pharmaceutical industry has produced measurable benefits. Doctors have new pharmaceuticals at their disposal, including many types of antibiotics and anti-viral drugs, vaccines and a (...) wide range of drugs which save lives or make them more comfortable. In the near future, ever more efficient cures for neoplastic, rheumatic, neurological, psychic, metabolic, circulatory or respiratory diseases can be expected. (shrink)

Critics of international trade agreements often cast them as threats to human health, and they can point to some sobering warnings from world history. Infectious diseases have swept across political boundaries, carried by traders, colonists, and other agents of globalization. Transnational epidemics have laid economies low, undermining political stability. The spread of viruses and bacteria to peoples previously unexposed and therefore lacking immunity has decimated populations and changed the political course of continents. Trade, exploration, and warfare have repeatedly produced (...) encounters between peoples at different levels of agricultural and technological development. Often, the results have been devastating for the disadvantaged group — economic marginalization, loss of sovereignty and culture, and collapse of public health. Yet the rise of civilization — plant and animal domestication, division of labor, technology, and resulting prosperity — was powered in large part by movement of products and knowledge along routes of trade and migration. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:A Vexed Pharmacopeia: Musings on Two Thousand Years of Scholarship Regarding the Ancient Spice Trade ROGER MICHEL ALEXY KARENOWSKA GEORGE ALTSHULER MATTHEW COBB Alice went back to the table. She found a little bottle on it, and round the neck of the bottle was a paper label, with the words “DRINK ME” beautifully printed on it in large letters. It was all very well to say “Drink me,” but (...) the wise little Alice was not going to do that in a hurry. “No, I’ll look first,” she said, “and see whether it’s marked ‘poison’ or not.” However, the bottle was not marked “poison,” so Alice ventured to taste it, and finding it very nice, (it had, in fact, a sort of mixed flavour of cherry-tart, custard, pine-apple, roast turkey, toffee, and hot buttered toast), she very soon finished it off. “What a curious feeling!” said Alice. —Lewis Carroll, Alice’s Adventures in Wonderland (1865) যে ব্যামোর দেখবেন সাতান্ন রকমের ওষুধ, বুঝে নেবেন, সে ব্যামো ওষুধে সারে না।1 —Syed Mujtaba Ali, চাচা কাহিনী (1955) introduction Mankind’s fascination with spice dates back at least 8,000 years—both culinary and medicinal herbs are referenced in the Vedas, Hinduism’s oldest religious text. Spice is also peppered throughout the Old Testament.2 The Song of Solomon recites: “Thy plants are an orchard of pomegranates, with pleasant fruits; camphire, with spikearion 28.1 spring/summer 2020 2 a vexed pharmacopeia nard and saffron; calamus and cinnamon, with all trees of frankincense; myrrh and aloes, with all the chief spices.”3 Every one of these fruits, plants and spices remained popular in the West throughout antiquity, into the Middle Ages, and beyond. As early as 3000 bc, trade routes had connected the Mediterranean to the near east. Courtesy of this “Spice Road,” ancient Mediterranean civilizations had access to a wide range of horseradishes, mustards, peppers, gingers and other spices. The Greeks and Romans had a special relationship with black pepper—so much so that four out of five recipes in Apicius’s famous 1st century cookbook4 called for a sprinkling of this sometimes-costly commodity. It is perhaps not coincidental that black pepper contains heat-producing alkaloids very similar to those found in New World chili peppers. Much has been written about the important role of chilis in South and Central American culture—a region that, by the Middle Ages, was in many respects the equal of Europe in “artistic sensibility, social complexity, and political organization.”5 The habanero and its capsainoid cousins were at the heart of the culinary and ceremonial customs of Mesoamerica, their biting heat and florid livery an apt metaphor for the “extravagant feats of human butchery”6 —very much in the tradition of the spectacular venationes of ancient Rome—for which the Aztecs at least were well known. To what extent was hot spice also a significant part of the culinary, medical and cultural landscape of the Old World? At a conference hosted by the Institute for Digital Archaeology at the University of Oxford last December, experts from Europe and North America examined the literary, historical, archaeological and scientific evidence around these questions. Their inquiry received a boost from new and rapidly developing techniques for examining the physical evidence of ancient diet and food production—laboratory techniques not available even five years ago. There was also fresh medical evidence to consider: significant research is being done in the area of chemosensation in the context of spicy foods. This Roger Michel, Alexy Karenowska, George Altshuler, Matthew Cobb 3 includes trying to understand how different so-called “TRP channels” in the nervous system process spice information— in particular, the connection between spice and endorphin levels. It appears that many of the hot spices available in antiquity could potentially trigger the same TRP channels as the capsaicin-charged Mesoamerican peppers. This creates a nice connection between old and new world spice that helps to explain and contextualize both. However, in the end, firm conclusions at the Oxford conference were scarce. It quickly became clear that more work, a greater diversity of viewpoints, better refined questions, and a change of venue were required to make additional progress. To paraphrase William Boot, the accidental protagonist of Evelyn Waugh’s autobiographical Scoop (wherein events around... (shrink)

This essay assesses the value of social constructivist theories of science to the history of medicine. It highlights particularly the ways in which feminist theorists have turned their attention to gender as a category of analysis in scientific thinking, producing an approach to modern science that asks how it became identified with "male" objectivity, reason, and mind, set in opposition to "female" subjectivity, feeling, and nature.In the history of medicine this new work has allowed a group of (...) scholars to better explain not only how women were marginalized in the profession but also the manner in which politics, male anxiety about shifts in power relations between the sexes, social and political upheaval, professional concerns, and changes in the family all had an impact on the production of knowledge regarding the female body, including the "discovery," definition, and treatment of a wide range of female ailments, from anorexia nervosa to fibroid tumors.Building on the work in the history of medicine already accomplished, the essay offers a critical rereading of the writings of Elizabeth Blackwell, a pioneer nineteenth-century woman physician and leader of the woman's medical movement. It contends that Blackwell, who lived through a revolutionary change in medical thinking brought on by discoveries in immunology and bacteriology, remained critical of "objectivity" as the "best" form of knowing and suspicious of the laboratory medicine that promoted it so enthusiastically. Moreover, her critiques of radical objectivity and scientific reductionism deserve to be recognized as foreshadowing the maternalist strain of thinking among contemporary feminist philosophers and thinkers such as Sara Ruddick and others. (shrink)

Genetic diseases can be every bit as devastating as the diseases caused by bacteria or viruses, and in one way they are much worse: we pass them on to our children, generation after generation after generation. Science and medicine have provided us with clues to the treatment of a few genetic diseases, although by their very nature they have never been considered curable. But, as William R. Clark shows, that is about to change through one of the most (...) profound revolutions in modern medicine: gene therapy, a branch of the new field of molecular medicine. The New Healers is a clear and compelling introduction to a revolution in modern medicine that may lead to cures for cancer, AIDS, and nearly 4,000 previously incurable genetic diseases. Clark introduces us to the scientists working on the vast Human Genome Project, and outlines all the basic elements of molecular biology necessary to understand this remarkable new medicine. (shrink)

The rapid growth of human population and associated industrialisation creates strains on resources and climate. One way to understand the impact of human activity is to quantify the total environmental pressures by measuring the ‘footprint’. Footprints account for the total direct and/or indirect effects of a product or a consumption activity, which may be related to e.g. carbon, water or land use, and can be seen as a proxy for environmental responsibility. Footprints shape climate and resource debates, especially concerning (...) environmental strategies. However, in general, footprints hold a dichotomous producer–consumer perspective that is not unanimously accepted. In addition, the current footprinting system transmits a simplistic message about environmental responsibility that taints the justice debate and jeopardises the validity of policies based on them. Consequently, it is crucial to question who is accountable for adverse environmental effects. It is also critical to investigate how the methodological characteristics of footprints shape and affect the efficacy of policies on climate and natural resources. This article examines these challenges, focusing on negative justice and policy implications resulting from assigning environmental responsibility to a sole agent. The article proposes, and morally justifies, the development of a footprinting method that includes justice parameters in an attempt to render fair results that are more meaningful for environmental action. The second objective is to establish the potential of this new framework to promote environmental responsibility and justice while facilitating policymaking. The suggested justice elements aim at turning footprints into a concrete environmental policy instrument framed under the value of environmental fairness. (shrink)

Plastids and mitochondria arose through endosymbiotic acquisition of formerly free-living bacteria. During more than a billion years of subsequent concerted evolution, the three genomes of plant cells have undergone dramatic structural changes to optimize the expression of the compartmentalized genetic material and to fine-tune the communication between the nucleus and the organelles. The chimeric composition of many multiprotein complexes in plastids and mitochondria (one part of the subunits being nuclear encoded and another one being encoded in the organellar genome) (...) provides a paradigm for co-evolution at the cellular level. In this paper, we discuss the co-evolution of nuclear and organellar genomes in the context of environmental adaptation in species and populations. We highlight emerging genetic model systems and new experimental approaches that are particularly suitable to elucidate the molecular basis of co-adaptation processes and describe how nuclear-cytoplasmic co-evolution can cause genetic incompatibilities that contribute to the establishment of hybridization barriers, ultimately leading to the formation of new species. (shrink)

The trend of emerging biorefineries is to process the harvest as efficiently as possible and without any waste. From the most valuable phytomass, refined medicines, enzymes, dyes and other special reactants are created. Functional foods, food ingredients, oils, alcohol, solvents, plastics, fillers and a wide variety of other chemical products follow. After being treated with nutrient recovery techniques, biofuels or soil improvers are produced from the leftovers. Economic optimization algorithms have confirmed that such complex biorefineries can be financially viable only (...) when a high degree of feedstock concentration is included. Because the plant material is extremely voluminous before processing, the farming intensity of special plants increases in the nearest vicinity of agglomerations where the biorefineries are built for logistical reasons. Interdisciplinary analyses revealed that these optimization measures lead to significantly increased pollen levels in neighbouring urban areas and subsequently an increased risk of allergies, respectively costs to the national health system. A new moral dilemma between the shareholder’s profit and public interest was uncovered and subjected to disputation. (shrink)

While visiting relatives in northern England in October 1865 the London chemist William Crookes witnessed firsthand the economic devastation of farming communities blighted by the cattle plague that had been sweeping Britain since June. Crookes delayed his return to London for several months and obtained official permission to begin experimenting on eradicating the disease with a new disinfectant, carbolic acid. In his report to the British government in 1866, Crookes was explicit that his experiments had been based on a germ (...) or contagion theory of the disease. Germs were considered to be airborne particles that might either be “living” material that “germinated” in the soil of animal flesh and blood or chemical poisons that decomposed flesh and blood.In the opening chapter of this fine study of the construction of British germ theories between the 1860s and 1900, Michael Worboys makes it clear that the cattle plague was a keystone in the long process of germ theory construction. Rinderpest was readily accepted by veterinary surgeons as a contagious disease to be controlled by wholesale culling with the poleax. On the other hand, they ignored or actively opposed the practical implications of a germ theory—disinfection , vaccination, and laboratory research—because these procedures posed a threat to the power and control of the veterinary profession. Plus ça change? In Britain, we are currently witnessing a similar example of party interest as a powerful Farmers' Union culls millions of cattle and sheep but prevents the use of vaccination in fighting a foot and mouth epidemic.Although a number of studies have celebrated the germ theory as the key development in producing scientific medicine in the late nineteenth century, this is the first critical book‐length study of its diffusion. The separate professional communities of veterinary practitioners, surgeons, and sanitarians are disarmingly shown to have developed different germ theories and differed over the practical consequences of their commitments. The closed subcultures inhabited by these groups meant that it took several decades before the germs of sanitarians were linked with those of surgeons and with the bacteria of microbiologists. Anyone who made a connection, such as the physicist John Tyndall, was dismissed as an inexpert interloper. Clearly, the singular specific disease germ theory was evolutionary in construction, not revolutionary.Worboys's ambitious monograph offers many fresh insights, including a finely tuned account of Joseph Lister's vacillating ideas and practices concerning wound management, and a splendid analysis of the problematic identification of specific germs causing cholera, smallpox, tuberculosis, diphtheria, typhoid fever, and scarlet fever. His meticulous survey of the contemporary literature unravels the deep uncertainty over whether “germs” were living organisms or chemicals, spontaneously generated or ancestral, causes or concomitants of disease. The fact that unpleasant wounds and the sick sometimes recovered spontaneously made sense only if patients constitutionally differed as an appropriate or inappropriate “soil” for “germ seeds” to blossom or perish. In this way ontological germ theories complemented the traditional medical concepts of constitutional strength and weakness and the healing power of nature. This insight underlines one of the strengths of the book, namely, its recognition of continuities in the construction of disease concepts and practices.Worboys successfully challenges the view that the British medical communities acted largely as onlookers while French and German practitioners honed a laboratory‐based medicine for the twentieth century. Overall, Worboys's monograph is a challenging and extremely readable medical history of germs. It will be essential reading for students taking history of medicine programs. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:FDA Releases Draft Guidance on Regulation of Genetically Engineered AnimalsJohn P. Gluck (bio) and Mark T. Holdsworth (bio)On 18 September 2008, the U.S. Food and Drug Administration (FDA) issued a draft set of guidelines for those involved in developing genetically engineered animals with heritable recombinant DNA (rDNA) constructs and is requesting comment from industry and the public about their content. The document does not impose new regulations but details (...) how existing laws and regulations apply to genetically engineered (GE) animals and offers advice to developers on how to negotiate the laws in the most efficient and productive manner. The draft guidance document is not legally enforceable at this juncture, but the guidelines are recommendations reflecting the FDA's "current thinking on a topic."The modification of GE animals being developed for commercialization, which are the focus of the document, fall into six categories: modifications intended to (1) enhance food quality—e.g., faster growing fish and meats with better nutritional profiles; (2) improve animal health via increased resistance to disease—e.g., mastitis in dairy cattle and Bovine Spongiform Encephalopathy (BSE); (3) create so-called "biopharm" animals capable of producing therapeutic products such as insulin, clotting factors, and tissues for human transplantation; (4) reduce the barriers to human animal interaction—e.g., hypoallergenic pets; (5) develop valid animal models of human disease—e.g., Parkinson's disease, Lesh-Nyhan's syndrome, and cancer; and (6) improve production of industrial or consumer products such as fiber. The timing of the guidelines coincides with the FDA's belief in an expected boon in the number of GE animals approaching the stage of commercialization.The FDA's involvement in the approval process emerges from the new animal drug provisions of the Federal Food Drug and Cosmetic Act and the definition of what constitutes a drug. The Act defines a new animal drug as "an article (other than food) intended to affect the structure or any function of the body of... animals." A rDNA construct intended to affect the structure or function of an animal meets the definition of a new animal drug, regardless of whether the resulting GE animals are intended for human food or the production of pharmaceuticals or any other substances. [End Page 393]Before proceeding to a review of the draft guidelines, it is important briefly to set the controversies around GE animals in historical and ethical context.The Ethical DebateFrom its inception, the intentional genetic modification or genetic engineering of molecules, plants, and animals by the techniques of gene splicing has consistently elicited strong responses from both the scientific community and the public. There are some data to suggest that although the concerns of scientists fall primarily into the category of possible biohazards, those of the public also reflect great concern about the intrinsic moral issues, such as whether there is something fundamentally wrong with this line of work, making it a form of forbidden knowledge (see, e.g., Gaskell 1997). When news of Paul Berg's attempts in 1970 to graft the primate tumor virus (SV 40) onto the intestinal tract bacteria Escherichia coli for the purpose of studying how normal cells may be transformed into cancerous cells was shared with colleagues, he was strongly encouraged to reflect on the potential public health risks if somehow the altered bacteria broke containment and entered the environment. Thanks to Berg's leadership, these concerns soon resulted in conferences held in Asilomar, California, and New Hampton, New Hampshire, where the ethical responsibilities of microbiologists involved in this research were discussed. These initial discussions resulted in what has come to be known as "The Moratorium Letter" (Shattuck 1996) published in the journal Science in 1974. This letter, signed by 11 leaders in the field, actually recommended restrictions on several types of experiments that were considered to be particularly risky and stated "that adherence to our major recommendations will entail postponement or possibly abandonment of certain types of scientifically worthwhile experiments" (Berg 1974). An international conference on the issues came to similar conclusions about the need for a research moratorium for the sake of public safety. Recommendations arising from conference participants led to the formation of the National Institutes... (shrink)

Foot-and-mouth disease was the event which led to the increased and improved training of veterinarians able to produce through their research new veterinary knowledge for practical application.It led to the transformation of the Mexican veterinary profession. It changed the kind of knowledge veterinarians received at university, and it also changed the work they did as professionals. Veterinarians gradually began to perform a much wider range of tasks: they did research, taught, worked as civil servants, or assumed positions as academic administrators (...) and as high governmental officials with a large amount of influence on governmental agricultural activities. They also engaged directly in animal husbandry and in food production.In parallel with these changes, the National University, and within it the Faculty of Veterinary Medicine and Animal Husbandry, underwent a concomitant series of changes which ran hand-in-hand with the growth of the Mexican state. The university provided training for specialised research workers by offering scholarships and programmes of graduate study. This consolidated the activities of an academic community working on applied veterinary medicine. The beneficiaries of these efforts take part in and influence, to varying degrees, the planning and programming of agricultural policies in a way that would not formerly have been possible. (shrink)

According to recent approaches in the philosophy of medicine, biomedicine should be replaced or complemented by a humanistic medical model. Two humanistic approaches, narrative medicine and the phenomenology of medicine, have grown particularly popular in recent decades. This paper first suggests that these humanistic criticisms of biomedicine are insufficient. A central problem is that both approaches seem to offer a straw man definition of biomedicine. It then argues that the subsequent definition of humanism found in these approaches (...) is problematically reduced to a compassionate or psychological understanding. My main claims are that humanism cannot be sought in the patient–physician relationship alone and that a broad definition of medicine should help to revisit humanism. With this end in view, I defend what I call an outcomes-oriented approach to humanistic medicine, where humanism is set upon the capacity for a health system to produce good health outcomes. (shrink)

The aim of this paper is to situate Addison’s aesthetics within the diverse, transdisciplinary aesthetic communication of the early eighteenth century, through which the new anthropology of sensibility took shape. Like many of his contemporaries, Addison draws on the medico-physiological literature of his time. Aesthetic pleasure is explained as consisting in or being produced by neurophysiological processes described in terms of iatromechanism and animal spirit physiology. These processes, he argues, are beneficial to the health and well-being of the human body (...) and mind, and can prevent and even cure mental diseases such as melancholy, which were thought to be caused by the disordered movement of the animal spirits. This means that aesthetic pleasure functions as a kind of therapeutic in Addison’s aesthetics. A comparison with his essays on therapeutic somatic practices reveals that Addison describes the neurophysiological processes involved in aesthetic pleasure in much the same way as those involved in physical exercise. When he refers to the pleasures of the imagination as “gentle exercise” (Spectator 411), Addison is drawing on the medico-physiological literature on exercise, especially Francis Fuller’s Medicina Gymnastica. For Addison, both physical exercise and the “gentle exercise” offered by aesthetic pleasure share the same normative goal: a “cheerful” mind, i.e. the lively movement and the proper distribution of animal spirits. Exercise, both physical and aesthetic, can achieve this by rearranging the movement of the animal spirits: exercise distracts the solitary, constricted and inert melancholic mind, releases the animal spirits from their confused and disordered movements by communicating to them a Motion contrary to theirs. In a way, both physical exercise and aesthetic pleasure re-connect or synchronise us with our environment: they lead the melancholic mind back to the beauty, novelty and greatness of nature, the delights of social life and the bounties of the providential order itself. For Addison, cheerfulness is much more than optimal neurophysiological functioning: it is a virtuous, sociable and pious “habit of mind” (Spectator 387) that makes us feel at home in our natural, social and providential world. Thus, due to its medical and physiological underpinnings, Addison’s aesthetics takes its place in the tradition of the “care of the self”, still reverberating in the eighteenth century, fusing medicine, aesthetics, morality and piety in the normative goal of the Addisonian quest for self-transformation: cheerfulness. (shrink)

The emerging concept of systems medicine (or ‘P4 medicine’—predictive, preventive, personalized and participatory) is at the vanguard of the post-genomic movement towards ‘precision medicine’. It is the medical application of systems biology, the biological study of wholes. Of particular interest, P4 systems medicine is currently promised as a revolutionary new biomedical approach that is holistic rather than reductionist. This article analyzes its concept of holism, both with regard to methods and conceptualization of health and disease. Rather (...) than representing a medical holism associated with basic humanistic ideas, we find a technoscientific holism resulting from altered technological and theoretical circumstances in biology. We argue that this holism, which is aimed at disease prevention and health optimization, points towards an expanded form of medicalization, which we call ‘holistic medicalization’: Each person’s whole life process is defined in biomedical, technoscientific terms as quantifiable and controllable and underlain a regime of medical control that is holistic in that it is all-encompassing. It is directed at all levels of functioning, from the molecular to the social, continual throughout life and aimed at managing the whole continuum from cure of disease to optimization of health. We argue that this medicalization is a very concrete materialization of a broader trend in medicine and society, which we call ‘the medicalization of health and life itself’. We explicate this holistic medicalization, discuss potential harms and conclude by calling for preventive measures aimed at avoiding eventual harmful effects of overmedicalization in systems medicine (quaternary prevention). (shrink)

Information medicine is a new application and development of an age-old method of healing. It re-creates and re-discovers a method that has proved its merits for thousands of years through a synthesis with new developments in new-paradigm physics and biology. The basic premise of information medicine is the use of information to correct faulty or blocked information-flows in the organism. As the latest discoveries, among others by Dr. Biava, show, even cancerous cells can be reprogrammed through the introduction (...) of substances that provide the correct information. Also, electromagnetic information can produce corrective re-programming, introducing an era of soft, information-based healing not as a substitute for, but as a complement to, the current biochemical substance and physical intervention-based methods. The information-based method I have developed is the one created by the Austrian scientist Erich Koerbler, called New Homeopathy. It harmonizes the electromagnetic field in the body through the use o... (shrink)

Oliva Sabuco's New Philosophy of Human nature (1587) is an early modern philosophy of medicine that challenged the views of the successors to Aristotle, especially Galen and Ibn Sina (Avicenna). It also challenged the paradigm of the male as the epitome of the human and instead offers a gender-neutral philosophy of human nature. Now largely forgotten, it was widely read and influential amongst philosophers of medicine including DeClave, LePois, Harvey,Southey and others, particularly for its account of the role (...) of the nervous system and cerebrospinal fluid in mind-body interaction. In this article I trace its early influence by tracing provenance of the editions produced during the lifetime of its author. (shrink)

Humankind is concerned with scientific enquiry because humans want to understand the milieu in which they find themselves. They want to engineer and reliably control or cooperatively modulate as much of the environment as possible to sustain, enrich, and propagate their lives. Following this path, the goal of science is to gain a reliable description of all natural phenomena so as to allow accurate prediction (within appropriate limits) of nature’s behavior as a function of an ever-changing environment. As such, science (...) is incapable of providing us with absolute truth. Rather, it provides relative knowledge, internally self-consistent knowledge, about the relationships between different phenomena and between different things. The goal of engineering, on the other hand, is to build on this fundamental understanding to generate new materials, devices, structures, attitudes, moralities, philosophies, and so on, for producing tangible order, harnessing the latent potential in nature’s phenomena and expanding human capabilities in an ever-changing environment. In this context, medicine is to human biology as engineering is to physical science. As each of us rides the “river of life,” the great consciousness adventure, we perceive events occurring around us, but more often than not, we do not perceive the total information content inherent in those events nor the true reality of those events. The latter point is so because what we take as the reality of an observation is actually a convolution between (1) what our sensory system actually senses and (2) our mindset or belief structure that filters and/or selectively amplifies segments of the basic gathered data stream. Further, only what we call the five physical senses are well-developed and integrated in our overall sensory system, so only a portion of the total available data becomes our basic internal data stream. We are thus always making personal observations through the distorting and spectrally-limited lens of our mindsets, and we have no way at present to perform a deconvolution and perceive the pure information inherent in our basic input data stream. By using designed instruments to access information patterns in nature, we gain a more objective perspective of these events. However, we must always remember that these instruments were designed on the basis of the logic of our average cognitive development and therefore probably also have only a limited access to the total information spectrum for these events occurring in nature. In particular, these instruments only respond to positive energies. Over the course of the past four to five centuries, we have learned how to conduct true scientific investigations, first under the rubric of classical mechanics and, more recently, quantum mechanics. Let us now look a little more deeply to see what this means. (shrink)

Do farmers in the southern Mexican highlands practice science? The anthropologist Roberto González argues that they do in his well‐written and solidly researched account of Zapotec farmers' cultivation of corn, sugarcane, and coffee. This book speaks to enduring questions concerning the nature of science through its focus on the often‐overlooked sophistication of traditional farming. Historians of science interested in agriculture, international development, and definitions of science more broadly will find in Zapotec Science a rich store of wide‐ranging questions and provocative (...) answers.González aims to move beyond the limitations of many sociological and anthropological studies of traditional societies. Many ignore international “cosmopolitan” influences, and most that do deal explicitly with these treat the traditional and the cosmopolitan as separate spheres. González finds no reason to treat these categories as nonoverlapping, as he documents how Zapotec farmers have experimented with and adopted techniques, implements, and crop varieties from many parts of the globe. And the flow goes both ways. Many so‐called cosmopolitan scientists are beginning to recognize the importance of traditional knowledge for solving problems in industrialized nations. But though the boundaries may be blurred, González argues that the conceptual bases of Zapotec agriculture are “culturally incommensurable with those predominating in industrialized societies” .In Chapter 1, González elaborates his position relative to other anthropological work on local science and traditional ecological knowledge and poses comparative questions about Zapotec and cosmopolitan science. Chapters 2 and 3 richly detail the daily practice of Zapotec agriculture and its environmental and geographical, cultural, and historical contexts. González emphasizes campesinos' craft, the refined skills that underlie every aspect of home, community, and agricultural life.González's research comes to the fore in the middle chapters on maize, sugarcane, and coffee cultivation. Here he clearly illustrates how Zapotec farming is founded on five fundamental values: household maintenance , mutual aid among families, personification of the earth and supernatural beings, an understanding of physical work as normal and desirable, and an emphasis on the quality of food over its quantity. For each crop he shows how present agricultural practices have emerged from an evolving balance between local crop development over hundreds or thousands of years and carefully weighed periodic opportunities to adopt new practices or plant varieties. Sugarcane cultivation, for example, illustrates how Zapotec farmers' decisions grow out of the five core values rather than a more narrow “economic rationality.” Zapotec communities do not consume cheap, white, processed sugar; rather, they produce and use an older, less processed, more expensive form called panela. Panela's persistence in their diet is due to its role in reciprocal social relationships and to Zapotecs' preference for high‐quality, good‐tasting food. The book concludes with a critique of Green Revolution development strategies and a lively discussion of the fertile borderlands between traditional and cosmopolitan knowledges.González's definition of science, closely related to Bronislaw Malinowski's, centers on practical knowledge. González argues that Zapotec farmers practiced science as they experimented with new techniques and implements from beyond Oaxaca's borders. Although traditional and cosmopolitan knowledge are conceptually distant, the author places great weight on what they share: both are systematic searches for practical knowledge. Traditional agriculture offers materials and methods that cosmopolitan scientists increasingly need.This book's strength lies, not surprisingly, near González's expertise: his careful description and analysis of Zapotec farmers' practices, logic, and values. As with all ambitious and worthwhile projects that pull together scientific enterprises that are culturally, geographically, and conceptually distant, González's book leaves questions unanswered. His characterization of cosmopolitan science is at times contradictory and often narrow. While Zapotec scientists are said to consider a variety of procedures and techniques and “adopt what seems to work according to their own categories, and reject what does not,” cosmopolitan scientists operate according to “one view, one procedure” . A more thorough characterization of cosmopolitan science would strengthen the comparisons with Zapotec farming and would complement the direct treatment that González provides for cosmopolitan science's exceptions, sustainable agriculture and alternative medicine. This would also help to clarify differences between natural scientists and development economists, whose values are often not distinguished. Furthermore, cosmopolitan science seems to dwell outside of Mexico. What would it look like to widen the lens to include the Mexican urban academic scientific community? How does this book speak to the wider literature on scientific practice that largely focuses on cosmopolitan science?Zapotec Science is an important contribution to our understanding of nonindustrialized agriculture outside of the United States. It will, I hope, prompt historians to delve into the historical relationships among people who employ agricultural knowledge toward divergent goals: scientists, farmers, and government leaders dwelling in different national and professional cultures. (shrink)

Climate change is an existential risk reinforced by ordinary actions in afuent societies—often silently present in comfortable and enjoyable habits. This silence is sometimes broken, presenting itself as a nagging reminder of how our habits fuel a catastrophe. As a case in point, global warming has created a state of urgency among wine makers in Spain, as the alcohol level has risen to a point where it jeopardises wine quality and thereby Spanish viticulture. Eforts are currently being made to solve (...) this problem technologically by developing (non-GMO) strains of yeast that produce less alcohol. If successful, this could help save Spanish viticulture. This kind of technological solution is routinely criticised for ofering simplistic “techno-fx” solutions to solve complex societal problems. However, it is not clear what features are criticised by the notion of techno-fx and hence how to avoid this criticism. In our interpretation, the techno-fx notion is not exclusively used as a dismissive term. The notion points to a general virtue of engineering: to create technological solutions that work silently in the background. This asset of technological solutions might sometimes be problematic and sometimes not. Hence, it needs to be analysed case-by-case by paying attention to the moral relevance of the hidden implications of the technology and of the unrefective actions and habits that they facilitate. Such moral analysis will in turn inform strategies for foregrounding this technology to counteract silencing. We discuss what this means in the case of modifying yeast as a viticultural climate resilience strategy. (shrink)

Modern medicine has produced many wonderful technological breakthroughs that have extended the limits of the frail human body. However, much of the focus of this medical research has been on the physical, often reducing the human being to a biological machine to be examined, understood, and controlled. This book begins by asking whether the modern medical milieu has overly objectified the body, unwittingly or not, and whether current studies in bioethics are up to the task of restoring a fuller (...) understanding of the human person. In response, various authors here suggest that a more theological/religious approach would be helpful, or perhaps even necessary. Presenting specific perspectives from Judaism, Christianity and Islam, the book is divided into three parts: "Understanding the Body," "Respecting the Body," and "The Body at the End of Life." A panel of expert contributors—including philosophers, physicians, and theologians and scholars of religion— answer key questions such as: What is the relationship between body and soul? What are our obligations toward human bodies? How should medicine respond to suffering and death? The resulting text is an interdisciplinary treatise on how medicine can best function in our societies. Offering a new way to approach the medical humanities, this book will be of keen interest to any scholars with an interest in contemporary religious perspectives on medicine and the body. (shrink)

Species concepts for bacteria and other microbes are contentious, because they are often asexual. There is a Problem of Homogeneity: every mutation in an asexual lineage forms a new strain, of which all descendents are clones until a new mutation occurs. We should expect that asexual organisms would form a smear or continuum. What causes the internal homogeneity of asexual lineages, if they are in fact homogeneous? Is there a natural “species concept” for “microbes”? Two main concepts devised for (...) metazoans and metaphytes have been applied to bacteria. One is the Recombination Concept, a revised form of the Biological Species Concept in which the homogenizing mechanism is the sharing of genome fragments, somewhat akin to sexual recombination. The other is the Ecological Species Concept, in which the ecological niche is that which maintains lineages as cohesive. In this paper I will discuss these two concepts, and offer an underlying model that conjoins them, and consider the implications for species concepts in general. In short, my argument is that asexual species are instances of the most primitive and underived notion of species, which I will call “quasispecies”, following Eigen, and that sexual species are merely one derived kind of species. Moreover, I will argue that there is a continuum of recombination from simple viral models in which each strain is a clone, through to obligate recombination of 50% of the parents’ genome, and that consequently there is no sharp division between “microbial” and more familiar species. (shrink)

Preface Phillip R. Sloan, Gerald McKenny, Kathleen Eggleson pp. xiii-xviii In November of 2009, the University of Notre Dame hosted the conference “Darwin in the Twenty-First Century: Nature, Humanity, and God.‘ Sponsored primarily by the John J. Reilly Center for Science, Technology, and Values at Notre Dame, and the Science, Theology, and the Ontological Quest project within the Vatican Pontifical... 1. Introduction: Restructuring an Interdisciplinary Dialogue Phillip R. Sloan pp. 1-32 Almost exactly fifty years before the Notre Dame conference, the (...) world’s largest centenary commemoration of Darwin’s legacy was held at nearby University of Chicago. This event, organized by a committee spearheaded by University of Chicago anthropologist Sol Tax, drew nearly 2,500 registrants. In attendance were the primary leaders... Part 1. Nature 2. Evolution through Developmental Change: How Alterations in Development Cause Evolutionary Changes in Anatomy Scott F. Gilbert pp. 35-60 For the past half-century, the mechanisms of evolution have been explained by the fusion of genetics and evolutionary biology called “the Modern Synthesis.‘ The tenets of the Modern Synthesis have been generally formulated as such: 1. There is genetic variation within the population. 2. There is competition... 3. The Evolution of Evolutionary Mechanisms: A New Perspective Stuart A. Newman pp. 61-89 The Modern Evolutionary Synthesis, based on Charles Darwin’s concept of natural selection in conjunction with a genetic theory of inheritance in a population-based framework, has been, for more than six decades, the dominant scientific perspective for explaining the diversity of living organisms. In recent years, however, with the growth... 4. The Evolvability of Organic Forms: Possible, Likely, and Unlikely Change from the Perspective of Evolutionary Developmental Biology Alessandro Minelli pp. 90-115 Confronted with the extraordinary diversity of animal form, we can ask questions about function and adaptation. How does this animal move? How does it feed? How does it defend itself from its enemies? But we can also ask questions about development, reproduction, and heredity. What mechanisms produce these forms? How are these... 5. Accident, Adaptation, and Teleology in Aristotle and Darwinism David J. Depew pp. 116-143 Charles Darwin framed the Origin of Species to meet criteria for inductive science set out by John Herschel in his Preliminary Discourse on the Study of Natural Philosophy. Accordingly, he was distraught when he learned that Herschel, to whom he had sent a copy of his newly published book, was not... 6. The Game of Life Implies Both Teleonomy and Teleology Gennaro Auletta, Ivan Colagè, Paolo D’Ambrosio pp. 144-164 The present contribution is mainly aimed at suggesting the importance of teleonomy and teleology as explanatory mechanisms in biology in the light of recent achievements in the field, and at showing that they play an actual and relevant role in the realm of life. The issue of finality in biology still provokes lively debates in the... Part 2. Humanity 7. Humanity’s Origins Bernard Wood pp. 167-181 One of Charles Darwin’s many achievements is that he began the process of converting the Tree of Life from a religious metaphor into a biological reality. All types of living organisms, be they animals, plants, fungi, bacteria, or viruses, are at the end of twigs that reach the surface of the Tree of Life, and all the types of organisms... 8. Darwin’s Evolutionary Ethics: The Empirical and Normative Justifications Robert J. Richards pp. 182-200 In the increasingly secular atmosphere of the nineteenth century, intellectuals grew wary of the idea that nature had any moral authority. In an earlier age, one might have looked upon the dispositions of nature as divinely sanctioned, and thus one could call upon natural law to ground moral judgment. Certain behaviors, for instance, might have... 9. Crossing the Milvian Bridge: When Do Evolutionary Explanations of Belief Debunk Belief? Paul E. Griffiths, John S. Wilkins pp. 201-231 Two traditional targets for evolutionary skepticism are religion and morality. Evolutionary skeptical arguments against religious belief are continuous with earlier genetic arguments against religion, such as that implicit in David Hume’s Natural History of Religion. Evolutionary arguments are also... 10. Questioning the Zoological Gaze: Darwinian Epistemology and Anthropology Phillip R. Sloan pp. 232-266 This quotation from Darwin’s Descent of Man illuminates an under-explored issue in Darwin’s work---not the issue of evolutionary ethics itself, but the epistemology of experience assumed in his work, and the consequences of his application of this “zoological gaze‘ to human beings. I will term this epistemological stance in this chapter “natural historical... Part 3. God 11. Evolution and Catholic Faith John O’Callaghan pp. 269-298 To begin to examine the relation of orthodox Catholic Christian faith to evolutionary theory and the question of human origins, consider words of the fourth pope, St. Clement: Let us fix our gaze on the Father and Creator of the whole world, and let us hold on to his peace and blessings, his splendid and surpassing... 12. After Darwin, Aquinas: A Universe Created and Evolving William E. Carroll pp. 299-337 At the 2000 Jubilee Session for scientists, held at the Vatican in May of that year, Archbishop Józef Życiński offered an eloquent assessment of contemporary discourse on the relationship between the natural sciences and theology. He ended his address with the comment that what is needed today is a new Thomas Aquinas. I remember... 13. Evolutionary Theism and the Emergent Universe Józef Życiński pp. 338-354 The 150th anniversary of the publication of Charles Darwin’s The Origin of Species has been celebrated in the context of an animated debate concerning both scientific and philosophical issues implied by the theory of evolution.1 One finds a deep diversity of attitudes, both methodological and semantic, in the current debates on evolutionary... 14. Beyond Separation or Synthesis: Christ and Evolution as Theodrama Celia Deane-Drummond pp. 355-380 The fervor with which popular discourse on science and religion has continued to bubble up in the anniversary year celebrating Darwin’s achievements shows that the publically perceived conflict between science and religion will not go away. Academic discussion on such matters is therefore not just peripheral to cultural concerns but takes... Part 4. Past and Future Prospects 15. Imagining a World without Darwin Peter J. Bowler pp. 383-403 What would have happened if Charles Darwin had not lived to write On the Origin of Species? Perhaps his bad health caused the early death he feared, or maybe he fell overboard while on the voyage of the Beagle. Would the world have still experienced the Darwinian Revolution under another name, or would the history of science, and... 16. What Future for Darwinism? Jean Gayon pp. 404-423 What future for Darwinism? I will propose some criteria for exploring this question in the domains of both evolutionary biology and the human sciences. Do not expect me to tell you where we will stand thirty years from now. It will be enough to identify a few general tendencies. For the sake of brevity, I will not devote a preamble to explain... Contributors pp. 424-430. (shrink)

In the last 10 years, we have witnessed a blooming of targeted genome editing systems and applications. The area was revolutionized by the discovery and characterization of the transcription activator‐like effector proteins, which are easier to engineer to target new DNA sequences than the previously available DNA binding templates, zinc fingers and meganucleases. Recently, the area experimented a quantum leap because of the introduction of the clustered regularly interspaced short palindromic repeats (CRISPR)‐associated protein (Cas) system (clustered regularly interspaced short palindromic (...) sequence). This ribonucleoprotein complex protects bacteria from invading DNAs, and it was adapted to be used in genome editing. The CRISPR ribonucleic acid (RNA) molecule guides to the specific DNA site the Cas9 nuclease to cleave the DNA target. Two years and more than 1000 publications later, the CRISPR‐Cas system has become the main tool for genome editing in many laboratories. Currently the targeted genome editing technology has been used in many fields and may be a possible approach for human gene therapy. Furthermore, it can also be used to modifying the genomes of model organisms for studying human pathways or to improve key organisms for biotechnological applications, such as plants, livestock genome as well as yeasts and bacterial strains. (shrink)

The study uncovers the drama of Stei Baita (Romania), a former uranium mine, which experienced during the communism period, an intensive industrialization. This shaped the territorial pattern, cultural, economic and social relationships, with a tremendous impact on the quality of the environment which was sacrificed against a rapid of a so-called economic growth. Stei Baita is a classic example of legacy mine land and the authors aim is to capture and assess all important aspects of sustainable development within this study-case (...) of disadvantaged community living in a radon prone area. More specifically, authors introduce their responses to several questions: (1) What do we know about social, economic and environmental capital of the selected settlement?; (2) Is the legacy of a uranium mine the platform of debate for negotiating for sustainable development?; and (3) What is the role of ethics in the current context of Stei Baita? Within the framework of analysis, equity, seen as part of ethics, is valued both as the premise of the debate and mandatory requirement for human development that should target sustainability. Authors have not discussed truths, but positions on identified problems by investigating community members’ perceptions. Thus, peculiarities of this community are dealt within a thematic context (e.g., resources and environment, individual development, social system). Finally, ethics is valued as social construct built by negotiating interpretations of morally desirable situations and behaviors accepted in a particular society at a certain historical moment. This view is consistent with ethical relativism which denies the existence of a unique moral truth and which sets the understanding of Stei Baita context on the path of the “new ethics”. The “new ethics” depicts the world in nuances, allowing society to surpass obstacles to the progress of understanding. (shrink)

Although beef and dairy production in Alberta, Canada, enjoys strong public support, there are enduring public concerns, including farm animal welfare. Evolving codes of practice and animal care councils prescribe changes and improvements to many areas of farm management, and may be seen by farmers as an appropriate response to public animal welfare concerns. However, codes of practice do not address every animal welfare concern, and new concerns can arise over time. Drawing on social practice theory and in-depth field research (...) with 36 cattle and dairy farmers, this paper explores the materials, competencies, and meanings of four animal husbandry practices: branding, dehorning, weaning, and on-farm handling and moving. Findings show that branding and dehorning are evolving slowly with attention to pain management, but remain firmly rooted in ranching tradition and communities of practice. Weaning and animal handling practices are evolving more quickly with attention to changing materials, attitudes, and values that are more prevalent within producer communities. (shrink)

Accepting as a given that the humanities disciplines are not product or “results” driven, this paper argues that the core of an interdisciplinary field of medicine and humanities, or medical humanities, is an interpretive enterprise that is not readily open to quantitative assessment. A more humanistically oriented medical practice can derive, however, from the process that produces new insights and works toward the development of a new, mutually shared, and humanizing language.

In _The Already Dead_, Eric Cazdyn examines the ways that contemporary medicine, globalization, politics, and culture intersect to produce a condition and concept that he names "the new chronic." Cazdyn argues that just as contemporary medicine uses targeted drug therapies and biotechnology to manage rather than cure diseases, global capitalism aims not for resolution but rather for a continual state of crisis management that perpetuates the iniquities of the status quo. Engaging critical theory, philosophy, and psychoanalysis, he explores (...) the ways that crisis affects perceptions of time and denies alternative ways of being and thinking. To resist the exploitative crisis state, which Cazdyn terms "the global abyss," he posits the concept of "the already dead," a condition in which the subject has been killed but has yet to die. Embracing this condition, he argues, allows for a revolutionary consciousness open to a utopian future. Woven into Cazdyn's analysis are personal anecdotes about his battle with leukemia and his struggle to obtain Canadian citizenship during his illness. These narratives help to illustrate his systemic critique, one that reconfigures the relationship between politics, capitalism, revolution, and the body. (shrink)

The article reevaluates the reception of Mendelism in France, and more generally considers the complex relationship between Mendelism and plant breeding in the first half on the 20th century. It shows on the one side that agricultural research and higher education institutions have played a key role in the development and institutionalization of genetics in France, whereas university biologists remained reluctant to accept this approach on heredity. But on the other side, plant breeders, and agricultural researchers, despite an interest in (...) Mendelism, never came to see it as the breeders' panacea, and regarded it instead as of only limited value for plant breeding. I account for this judgment in showing that the plant breeders and Mendelism designed two contrasting kinds of experimental systems and inhabited distinct experimental cultures. While Mendelian geneticists designed experimental systems that allowed the production of definite ratios of different forms that varied in relation to a few characters, plant breeders' experimental systems produced a wide range of variation, featuring combinations between hundreds of traits. Rather than breaking this multiple variation down into simple elements, breeders designed and monitored a genetic lottery. The gene was a unit in a Mendelian experimental culture, an "epistemic thing" as Rheinberger put it, that could be grasped by means of statistical regularities, but it remained of secondary importance for French plant breeders, for whom the strain or the variety -- not the gene -- was the fundamental unit of analysis and manipulation. (shrink)

ArgumentWhen Pasteur and Chamberland hastily set up their small biological industry to meet the agricultural demand for the anthrax vaccine, their methods for preparation and production had not yet been stabilized. The process of learning how to standardize biological products was accelerated in 1882 when vaccination accidents required the revision of production norms as the first hypotheses on fixity, inalterability, and transportability of vaccines were invalidated and replaced by procedures for continuous monitoring of the calibration of vaccines and the renewal (...) of vaccine strains. Initially, the incompleteness and ongoing development of production standards justified Pasteur's monopoly on the production of the anthrax vaccine under his immediate supervision. Later on, the Pasteur Institute maintained control of these standards in the framework of a commercial monopoly that it established on the veterinary vaccines first sent and then cultivated abroad by the Société de Vulgarisation du Vaccin Charbonneux Pasteur, founded in 1886. (shrink)

We have a thriving biotechnology industry in the United States. There are over 1,450 biotechnology companies developing diagnostic and treatment technologies in medicine, creating more nutritional foods, and innovating new industrial processes. Yet this $28.5 billion sector of the economy is not without controversy. The “bio” in biotechnology comes from living, biological entities - people, plants, animals, and even bacteria. In the realm of biobanking, people are the source of the raw material for the discovery of genes (...) for research, diagnosis, and therapy, raising a host of issues about rights and responsibilities, fiduciary duties and societal obligations. (shrink)

Cybernetic Bacteria is an ongoing transdisciplinary investigation that brings together art, philosophy, microbiology and digital technology to examine the relationship of the emerging science of bacterial communication to our own digital communications networks, looking in particular at ‘packet data’ and bacterial quorum sensing. The project seeks to compare philosophical notions of the sublime with a kind of bacterial sublime, demonstrating the greater complexity of the interactions taking place at a microscopic level, when compared to human communication technologies such as (...) the World Wide Web (with particular focus on scale-free networks). The first artwork in the series employed a clear plastic tube of liquid agar jelly planted into earth to allow the soil bacteria beneath to grow upwards and become visible. A total of 100 µL of Homoserine Lactone, a hormone used by bacteria for quorum sensing (a form of bacterial communication), was then added by the artist as part of a performance lecture, with her in effect saying: ‘I’m here’ to the bacteria below. The microbes that have been communicated to then pass the signal on to their neighbours and so on. In theory this enables the signal to travel around the planet. However, the main issue with this work is one of Hermeneutics; the bacteria, which receive the communication, will not identify the artist as human – simply as another (albeit very large) bacterium. The project has subsequently evolved into a multiple screen digital artwork showing network traffic taking place in real time (web traffic, RFID and Bluetooth), a film of bacterial communication in progress (using two strains of genetically modified bacteria) and an interactive conceptualisation of the data from both sources generated using artificial life. The project continues. (shrink)

The 1940s and 1950s were marked by intense debates over the origin of drug resistance in microbes. Bacteriologists had traditionally invoked the notions of ‘training’ and ‘adaptation’ to account for the ability of microbes to acquire new traits. As the field of bacterial genetics emerged, however, its participants rejected ‘Lamarckian’ views of microbial heredity, and offered statistical evidence that drug resistance resulted from the selection of random resistant mutants. Antibiotic resistance became a key issue among those disputing physiological vs. genetic (...) explanations of variation in bacteria. Postwar developments connected with the Lysenko affair gave this debate a new political valence.Proponents of the neo-Darwinian synthesis weighed in with support for the genetic theory. However, certain features of drug resistance seemed inexplicable by mutation and selection, particularly the phenomenon of ‘multiple resistance’—the emergence of resistance in a single strain against several unrelated antibiotics. In the late 1950s, Tsutomu Watanabe and his collaborators solved this puzzle by determining that resistance could be conferred by cytoplasmic resistance factors rather than chromosomal mutation. These R factors could carry resistance to many antibiotics and seemed able to promote their own dissemination in bacterial populations. In the end, the vindication of the genetic view of drug resistance was accompanied by a recasting of the ‘gene’ to include extrachromosomal hereditary units carried on viruses and plasmids. (shrink)

The humanist tradition developed in the Renaissance that not only cultivated the human spirit but applied its knowledge for the purpose of improving society across various humanist and scientific disciplines is not altogether extinct. Using the erudite Swiss physician and botanist Anton Schneeberger (1530–1581) as a founding father of sorts of modern humanist medicine confronted with war, I discuss the recuperation of humanism in the twentieth century, first in the thought of psychologist Kurt Lewin (1890–1947) who, under war circumstances, (...) produced a work whose analytical acumen can still be used today, and subsequently in the creation of the discipline of narrative medicine that, unwittingly perhaps, echoes Schneeberger’s insight into the imperative of inserting storytelling into the practice of both patient- and physician-centered medicine. In the background of the argument is the existence of a new society, a martial society that functions as if there were war despite its ostensible state of peace. (shrink)

Edmund D. Pellegrino has played a central role in shaping the fields of bioethics and the philosophy of medicine. His writings encompass original explorations of the healing relationship, the need to place humanism in the medical curriculum, the nature of the patient’s good, and the importance of a virtue-based normative ethics for health care. In this anthology, H. Tristram Engelhardt, Jr., and Fabrice Jotterand have created a rich presentation of Pellegrino’s thought and its development. Pellegrino’s work has been dedicated (...) to showing that bioethics must be understood in the context of medical humanities, and that medical humanities, in turn, must be understood in the context of the philosophy of medicine. Arguing that bioethics should not be restricted to topics such as abortion, third-party-assisted reproduction, physician-assisted suicide, or cloning, Pellegrino has instead stressed that such issues are shaped by foundational views regarding the nature of the physician-patient relationship and the goals of medicine, which are the proper focus of the philosophy of medicine. This volume includes a preface by Dr. Pellegrino and a comprehensive Introduction by the editors. Of interest to medical ethicists as well as students, scholars, and physicians, _The Philosophy of Medicine Reborn_ offers fascinating insights into the emergence of a field and the work of one of its pioneers. “After a long period of dormancy, philosophy of medicine has blossomed with new life. The single most important physician-philosopher in that rebirth has been Edmund Pellegrino. His contributions to virtue theory, the concept of beneficence, the dispute over the internal and external sources of a morality for medicine, and the role of the Hippocratic tradition are all critical. The essays collected in this volume have changed the history of the philosophy of medicine. He shows that philosophy of medicine can be done with both passion and compassion.” —_Robert M. Veatch, Kennedy Institute of Ethics, Georgetown University_ “Edmund Pellegrino's words have helped medical students, faculty, scholars and patients address the challenges they encounter in medicine and medical practice. His personal support has also been critical for many of us in developing programs in medical ethics and philosophy of medicine in our universities. Dr. Pellegrino combines the wisdom of a great physician with those of a great philosopher to produce a body of writing that will continue to inspire us all. This volume contains some of his best and most influential work.” —_Loretta Kopelman, The Brody School of Medicine, East Carolina University_ _ _ “Edmund Pellegrino has been a leading light in the philosophy of medicine for a generation. He was instrumental in the birth of bioethics, founded one of the leading journals, and provided able leadership in organizing early activities of the profession. He has served as department chairman, dean, and university president. Most recently, he chairs the President’s Council on Bioethics. In all this, first and foremost, he has been a physician. Those who are ill and suffering make a claim upon him. To respond to this claim, Pellegrino creatively brings together the worlds of science and of the humanities. For him, that is what medicine is about, making it the most scientific of the humanities and the most humane of the sciences. Fortunately for us, Pellegrino brings these worlds together in thought, as well as in practice. In this selection from his writings, Engelhardt and Jotterand have captured the heart of Pellegrino’s project, both in depth and breadth, so we can also hear that claim of the ill and so we can see what worlds must come together if we are to respond in the appropriate way.” —_George Khushf, University of South Carolina_ “Pellegrino’s work is both a treasure and important for understanding bioethics. His work in philosophy of medicine addresses the crucial questions that are so important to understanding the practice of medicine and the ethics of health care.” —_Kevin Wildes, President, Loyola University_ _ _. (shrink)

Globalization is hailed by its advocates as a means of spreading cosmopolitan values, ideals of sustainability and better standards of living all around the world. Its critics, however, see globalization as a new form of colonialism imposed by rich countries and transnational corporations on the rest of the world, a process in which the rhetoric of sustainability and equality does not match the realities of exploitation and impoverishment of people and nature. This paper endorses neither view. Globalization is not new, (...) but it continually produces new challenges for conceptions of 'home' and 'belonging'. While some enthusiasts regard the 'liberal' and 'environmental' values of the West as the best remedy for what is wrong with the world, others argue that a resource for resisting the destructive effects of globalization may be found in the sense of identity and importance of place found in the traditional scientific and medical traditions of both India and China. Instead of trying to merge these two views in some grand synthesis, this paper argues that traditional conservative and modern liberal values should continually interact with each other to produce novel ideas in debates about home, place and belonging. (shrink)