Accuracy‐first epistemology is an approach to formal epistemology which takes accuracy to be a measure of epistemic utility and attempts to vindicate norms of epistemic rationality by showing how conformity with them is beneficial. If accuracy‐first epistemology can actually vindicate any epistemic norms, it must adopt a plausible account of epistemic value. Any such account must avoid the epistemic version of Derek Parfit's “repugnant conclusion.” I argue that the only plausible way of doing so is to say that accurate credences (...) in certain propositions have no, or almost no, epistemic value. I prove that this is incompatible with standard accuracy‐first arguments for probabilism, and argue that there is no way for accuracy‐first epistemology to show that all credences of all agents should be coherent. (shrink)

Moral or ethical questions are vital because they affect our daily lives: what is the best choice we can make, the best action to take in a given situation, and ultimately, the best way to live our lives? Health ethics has contributed to moving ethics toward a more experience-based and user-oriented theoretical and methodological stance but remains in our practice an incomplete lever for human development and flourishing. This context led us to envision and develop the stance of a “living (...) ethics”, described in this inaugural collective and programmatic paper as an effort to consolidate creative collaboration between a wide array of stakeholders. We engaged in a participatory discussion and collective writing process known as instrumentalist concept analysis. This process included initial local consultations, an exploratory literature review, the constitution of a working group of 21 co-authors, and 8 workshops supporting a collaborative thinking and writing process. First, a living ethics designates a stance attentive to human experience and the role played by morality in human existence. Second, a living ethics represents an ongoing effort to interrogate and scrutinize our moral experiences to facilitate adaptation of people and contexts. It promotes the active and inclusive engagement of both individuals and communities in envisioning and enacting scenarios which correspond to their flourishing as authentic ethical agents. Living ethics encourages meaningful participation of stakeholders because moral questions touch deeply upon who we are and who we want to be. We explain various aspects of a living ethics stance, including its theoretical, methodological, and practical implications as well as some barriers to its enactment based on the reflections resulting from the collaborative thinking and writing process. (shrink)

Sometimes a belief that p promotes having true beliefs, whether or not p is true. This gives reasons to believe that p, but most epistemologists would deny that it gives epistemic reasons, or that these reasons can epistemically justify the belief that p. Call these reasons to believe “truth promoting non-evidential reasons for belief.” This paper argues that three common views in epistemology, taken together, entail that reasons of this sort can epistemically justify beliefs. These three claims are: epistemic oughts (...) are normative, epistemic oughts have a source, and the source of epistemic oughts is an end that has true belief as a necessary component. These claims would be hard for many epistemologists to deny, but accepting them, and thus accepting that truth promoting non-evidential reasons can justify beliefs, has significant consequences for epistemology. The paper considers accounts of epistemic oughts that endorse these claims but might seem to avoid the consequence that truth promoting non-evidential reasons generate real epistemic oughts, and shows that none do. (shrink)

The epistemic norms should matter. The ones philosophers typically focus on do not matter enough. They should be replaced. This book discusses a range of views of why and how epistemic norms could matter and shows how epistemic norms as standardly understood fall short on each. No matter how the importance of the epistemic is to be explained, it does not matter at all what we believe about most topics or why we believe it. When what we believe does matter, (...) it is often not particularly important that our beliefs are true, but rather that they are good enough for our purposes, and thus no truth-connected epistemic notion such as reliability, evidence, coherence, accuracy, or knowledge is really relevant. Finally, even when truth is genuinely important, standard epistemic norms do not properly aim at the truth, because they do not allow us to sacrifice one true belief for the sake of others. In light of all of this, epistemic norms as standardly conceived are not really concerned with what matters. We can and should do better. The epistemic norms that genuinely matter will replace truth-based epistemic notions with conceptions of success, reasons, and justification aimed at the “good enough.” They will require us to form some seemingly bad beliefs—beliefs that violate all standard norms by going against our evidence, being incoherent, or even being clearly false—in order to improve other beliefs. In fact, they will sometimes allow our beliefs to be bad for no reason whatsoever. (shrink)

This paper explores the justifications and impression management strategies that industrial companies use to rationalize their impacts on climate change. These strategies influence the perceptions of stakeholders through the use of techniques of neutralization intended to legitimize the impacts of corporate operations in the area of climate change. Based on a qualitative and inductive approach, 10 case studies were conducted of large Canadian industrial emitters. Interviews were conducted with managers and environmental specialists. Public documentation was also collected when available. This (...) study identifies six main neutralization techniques that industrial emitters use to rationalize their impacts: self-proclaimed excellence, promotion of a systemic view, denial and minimization, denouncing unfair treatment and deceptive appearances, economic and technological blackmail, and blaming others. The paper develops a better understanding of corporate arguments and strategies aimed at influencing the perceptions of stakeholders, including policymakers. The study also contributes to the literature on impression management by shedding light on new strategies and techniques of neutralization used by managers to shape the perceptions of stakeholders on socially sensitive issues. (shrink)

The objective of this study was to analyze the quality of climate information disclosed by companies and the impression management strategies they have developed to justify or conceal negative aspects of their performance. The study is based on a qualitative content analysis of the sustainability reports of 21 energy-sector companies that use the Global Reporting Initiative with A or A+ application levels over a period of 5 years. It contributes to the literature on climate disclosure by demonstrating the ineffectiveness of (...) the external assurance process in ensuring the quality and representativeness of the data. Significant non-compliance with GRI standards was identified in 86 of the 93 reports audited by a third party. In addition, six of the 21 companies surveyed were found to disclose increasingly opaque information over time, concealing information on the measurement and methodology used. Through this study, four impression management strategies were identified. These are employed either to justify certain information or to conceal it. In exposing the high incidence of non-compliance in GRI reporting and the use of impression management strategies by companies, this study shows that it will be difficult or impossible for stakeholders to reasonably assess, monitor and compare companies’ climate performance on the basis of these reports. (shrink)

The objective of this longitudinal study is to analyze the intrinsic drivers and values underlying managers’ organizational citizenship behaviors for the environment from a developmental psychology perspective based on measuring the stages of consciousness that shape the meaning-making systems of individuals. At time 1, the stages of consciousness of 138 managers were qualitatively assessed using the Leader Development Profile test. At time 2, a quantitative survey measured the environmental beliefs and OCBEs of these managers. The links between stages of consciousness, (...) environmental beliefs, and OCBEs were analyzed using hierarchical regressions. The main findings show that managers’ stages of consciousness positively influence two types of OCBEs, namely eco-initiatives and eco-helping, while environmental beliefs influence eco-helping and eco-civic engagement but do not appear to be connected with the stage of consciousness development. This paper first contributes to the literature on corporate greening by shedding more light on the aspects of behavioral and developmental psychology that underlie environmental leadership. Second, it bridges the gap between theories that have developed separately by showing the interconnectedness between the managers’ stage of consciousness and the more concrete environmental behaviors in the workplace that could have emulative effects throughout the organization. (shrink)

Recently, a number of philosophers have turned to folk intuitions about mental states for data about qualia and phenomenal consciousness. In this paper I argue that current research along these lines does not tell us about these subjects. I focus on a series of studies, performed by Justin Sytsma and Edouard Machery, to make my argument. Folk judgments studied by these researchers are mostly likely generated by a certain cognitive system – System One – that will generate the same data (...) whether or not we experience phenomenal consciousness. This is a problem for a range of current experimental philosophy research into consciousness or our concept of it. If experimental philosophy is to shed light into phenomenal consciousness, it needs to be better founded in an understanding of how we make judgments. (shrink)

: This paper addresses the need to examine teaching practices from the observation that they are beyond what they should be. This task devolved to scientists of education is to learn about teaching practices in their relationship to student learning in order to build the database useful to teacher educators and reflexivity necessary for any teacher about their own practice. The concepts of competence, pattern and are useful instrument in this endeavor of explanation and understanding of the practices. The proposed (...) theoretical framework is illustrated by a perspective of teaching practices of teachers in schools and colleges. These differ in many aspects and this requires the testing of new hypotheses to explain -/- La présente contribution traite de la nécessité d’étudier les pratiques d’enseignement à partir du constat de ce qu’elles sont au delà de ce qu’elles devraient être. Cette tâche dévolue aux chercheurs en sciences de l’éducation vise à mieux connaître les pratiques d’enseignement dans leurs relations aux apprentissages des élèves afin de constituer la base de données utiles aux formateurs d’enseignants et nécessaire à toute réflexivité des enseignants à propos de leur propre pratique. Les notions de compétence, de schème et d’instrument sont utiles à cette entreprise d’explication et de compréhension des pratiques. La proposition de cadrage théorique est illustrée par une mise en perspective des pratiques d’enseignement de professeurs des écoles et de collèges. Celles-ci se distinguent sur bien des aspects ce qui réclame la mise à l’épreuve de nouvelles hypothèses explicatives. (shrink)

Enormous harms, such as climate change, often occur as the result of large numbers of individuals acting separately. In collective action problems, an individual has so little chance of making a difference to these harms that changing their behavior has insignificant expected utility. Even so, it is intuitive that individuals in many collective action problems should not be parts of groups that cause these great harms. This paper gives an account of when we do and do not have obligations to (...) change our behavior in collective action problems. It also addresses a question insufficiently explored in the literature on this topic: when obligations arising out of collective action problems conflict with other obligations, what should we do? The paper explains how to adjudicate conflicts involving two collective action problems and conflicts involving collective action problems and other sorts of obligations. (shrink)

To argue that “ought” implies “can,” one can appeal to general principles or to intuitions about specific cases. One general truism that seems to show that “ought” implies “can” is that obligations must be able to guide action, and putative obligations that are unfulfillable are unable to do so. This paper argues that obligations that are unfulfillable can still guide action, and that moral theories which reject the principle that “ought” implies “can” are actually better able to account for how (...) obligations guide than theories which endorse “ought” implies “can.” The paper also argues that any intuitions about specific cases that seem to provide evidence that “ought” implies “can” do not actually give us this evidence. Rather, these intuitions pose similar problems for theories which accept “ought” implies “can” as they pose for theories which reject the principle. Some theories which reject “ought” implies “can” will fit our intuitions at least as well, if not better, than theories which accept it. So, intuitions do not favor accepting that “ought” implies “can,” and appeal to general principles favors its denial. (shrink)

The objective of this paper is to explore, through a qualitative study of small regional airports, how sustainability issues are taken into account in remote small- and medium-sized enterprises. Based on 42 semi-structured interviews conducted with managers of small regional Canadian airports and experts in this area, this study shows the quasi-absence of specific measures for sustainability, despite the seriousness of environmental issues, which tend to be subordinated to economic priorities and operational activities. The paper contributes to the literature on (...) sustainability in SMEs by focusing on passive organizations located in remote areas and the complex reasons underlying their lack or absence of environmental commitment. The paper sheds more light on the essential role of stakeholders in providing the resources and skills necessary for the development of sustainability initiatives in passive SMEs. The study’s managerial contributions and implications for stakeholders are also discussed. (shrink)

One mainstream approach to philosophy involves trying to learn about philosophically interesting, non-mental phenomena—ethical properties, for example, or causation—by gathering data from human beings. I call this approach “wide tent traditionalism.” It is associated with the use of philosophers’ intuitions as data, the making of deductive arguments from this data, and the gathering of intuitions by eliciting reactions to often quite bizarre thought experiments. These methods have been criticized—I consider experimental philosophy’s call for a move away from the use of (...) philosophers’ intuitions as evidence, and recent suggestions about the use of inductive arguments in philosophy—and these criticisms point out important areas for improvement. However, embracing these reforms in turn gives wide-tent traditionalists strong reasons to maintain other traditional approaches to philosophy. Specifically, traditionalists’ commitment to using intuitions and to gathering them with bizarre thought experiments is well founded, both philosophically and empirically. I end by considering some problems with gathering trustworthy intuitions, and give suggestions about how best to solve them. (shrink)

I present a novel approach to teaching ethics to students who are moral relativists. I argue that we should not try to convince students to abandon moral relativism; while we can and should present arguments against the view, we should not try to use these arguments to change students’ minds. Attempts to convince student relativists to change their minds can be disrespectful, and often overlook the reasons why students are relativists. I explain how instead to show moral relativists that their (...) commitment to relativism is also a commitment to studying ethics rigorously and engaging with the views of others. This approach is easier and more respectful than alternatives, and openness to relativism encourages good pedagogy. (shrink)

This paper aims to clarify a debate on philosophical method, and to give a probabilistic argument vindicating armchair philosophy under a wide range of plausible assumptions. The use of intuitions by so-called armchair philosophers has been criticized on empirical grounds. The debate between armchair philosophers and their empirical critics would benefit from greater clarity and precision in our understanding of what it takes for intuition-based approaches to philosophy to make sense. This paper discusses a set of rigorous, probability-based tools for (...) determining what we can and cannot learn from intuitions in various conditions. These tools can tell us whether beliefs can be justified by armchair practices, and what empirical findings would have to show to undermine the use of intuitions in philosophy. Using these tools, the paper shows that armchair philosophy makes sense in a broad range of situations, and that it is quite plausible that we are in those situations at the moment. (shrink)

This book explores the way in which, working within the investigative tradition associated with the Royal Society, the philosopher John Locke (1632-1704) used ...

The letters transcribed in this book were written by physicist David Bohm to three close female acquaintances in the period 1950 to 1956. They provide a background to his causal interpretation of quantum mechanics and the Marxist philosophy that inspired his scientific work in quantum theory, probability and statistical mechanics. In his letters, Bohm reveals the ideas that led to his ground breaking book Causality and Chance in Modern Physics. The political arguments as well as the acute personal problems contained (...) in these letters help to give a rounded, human picture of this leading scientist and twentieth century thinker. (shrink)

There is widespread controversy about the use of intuitions in philosophy. In this paper I will argue that there are legitimate concerns about this use, and that these concerns cannot be fully responded to using the traditional methods of philosophy. We need an understanding of how intuitions are generated and what it is they are based on, and this understanding must be founded on the psychological investigation of the mind. I explore how a psychological understanding of intuitions is likely to (...) impact a range of philosophical projects, from conceptual analysis to the study of (non-conceptual) "things themselves" to experimental philosophy. (shrink)

An understanding of the ethical implications of their work is now essential for all scientists. This accessible textbook clearly explains bioethical theories and their philosophical foundations to science students, enabling them to confidently take part in the key ethical debates of biotechnology. Over 200 activities introduce topics for personal reflection and discussion points encourage students to think for themselves and build their own arguments. Highlighting the potential pitfalls for those new to bioethics, each chapter features boxes providing factual information and (...) outlining the philosophical background. Accompanying online podcasts by the author (two of whose podcasts on iTunesU have attracted over 3 million downloads) explain points that might be difficult for beginners. Detailed case studies provide an insight into real-life examples of bioethical problems. Within-chapter essay questions and quizzes, along with end-of-chapter review questions, allow students to check their understanding and encourage broader thinking about the topics discussed. (shrink)

To consequentialize a deontological moral theory is to give a theory which issues the same moral verdicts, but explains those verdicts in terms of maximizing or satisficing value. There are many motivations for consequentializing: to reconcile plausible ideas behind deontology with plausible ideas behind consequentialism, to help us better understand deontological theories, or to extend deontological theories beyond what intuitions alone tell us. It has proven difficult to consequentialize theories that allow for moral dilemmas or that deny that “ought” implies (...) “can.” This article argues that the problem is best solved by allowing impossible actions as inputs into consequentializations. It shows that all other approaches that have been advocated are inadequate. It also argues that progress in consequentialization, and in formal ethics more generally, requires thinking about more than just wrongness and permissibility; we should think about contrary-to-duty obligations and degrees of wrongness as well. (shrink)

An account of how quantum physics is putting forward ideas that confirm the perceived beliefs of mystics who think the world is an illusion.

This article argues that, as applied to education, the Capabilities Approach pioneered by Amartya Sen and Martha Nussbaum shares a range of philosophical commitments with the work of social realist scholars on the concept of ‘powerful knowledge’. I first trace the history of the concept of powerful knowledge and present critiques put forward by social justice scholars. I then outline the Capabilities Approach, arguing it provides a response to some of these concerns. From here I develop the connection between the (...) two educational paradigms focusing on four areas of affinity. The first is the conceptual similarity between the ‘power’ of powerful knowledge and Nussbaum’s account of a capability. The second is their concern with the reduction of education to technical-instrumentalism, human capital, and other economically driven imperatives. The third is a shared focus on the link between knowledge, human agency, and freedom. The fourth, is a mutual rejection of relativism and embrace of a nuanced universalism. Ultimately, by drawing together these two conceptually rich approaches to the aims and purposes of education, I hope to open a space for theorizing about both capabilities and powerful knowledge that can resolve some of the problems in both. For powerful knowledge, the Capabilities Approach allows a more concrete explication of why access to disciplinary bodies of knowledge is of value to both individuals and society. On the side of the Capabilities Approach, engaging with the concept of powerful knowledge can help give a rationale for how educational knowledge fosters certain centrally important capabilities. (shrink)

Imagine that one must either lose all of one’s certainty about some very important topic – about the meaning of life, for example – or a small amount of certainty about each of one’s more “mundane” beliefs – beliefs about the color of one’s socks, where one’s keys are, whether it will rain, etc. One ought to take the latter loss, no matter how many mundane beliefs are at stake. Conversely, if one had to give up a tiny bit of (...) certainty about the important topic, or all of one’s certainty about most mundane topics, one ought to take the former loss. These two judgments generate what I call the “epistemic headaches-for-lives challenge,” so called because it resembles a challenge in ethics about the relative values of headaches and lives. In this paper, I argue for two things. First, our epistemic theories should accord with these types of judgments, and so must deal with the headaches-for-lives challenge. Second, this is a serious challenge for formal epistemology. (shrink)

Proposes an original theory of the ethic of care, drawing insights from feminist and non-feminist critics of liberal moral theory, feminist ethics and ...

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease, primarily leading to the degeneration of motor neurons. The traditional focus on motor neuron‐centric mechanisms has recently shifted towards understanding the contribution of non‐neuronal cells, such as microglia, in ALS pathophysiology. Advances in induced pluripotent stem cell (iPSC) technology have enabled the generation of iPSC‐derived microglia monocultures and co‐cultures to investigate their role in ALS pathogenesis. Here, we briefly review the insights gained from these studies into the role of microglia in ALS. (...) While iPSC‐derived microglia monocultures have revealed intrinsic cellular dysfunction due to ALS‐associated mutations, microglia‐motor neuron co‐culture studies have demonstrated neurotoxic effects of mutant microglia on motor neurons. Based on these findings, we briefly discuss currently unresolved questions and how they could be addressed in future studies. iPSC models hold promise for uncovering disease‐relevant pathways in ALS and identifying potential therapeutic targets. (shrink)

Believing that traditional Christian theism implies there is something epistemically wrong with religious unbelief, I examine John Calvin’s claim that everybody would believe in God if it weren’t for sin. I show why this claim ought to be more common than it is; develop it in terms of our naturally having certain reliable epistemic sets; utilize that development to specify exactly what is wrong with unbelief; and then argue that even unbelievers have some reason to think it is true.

Inspired by the life and works of GrammyAward® winning artist, Lil Nas X, we explore ways a young Black queer musician has enacted emancipatory utopias to disrupt dominant cultural modes of being—offering unapologetic expressions and expansions of race, gender, and sexual identity. In this paper, we draw upon José Esteban Muñoz and Ytasha Womak to consider how utopian thinking through the lenses of queer futurity and Afrofuturism provides a way to dismantle the hegemonic and proleptic trappings of music education and (...) contemplate how music learners and teachers might enact emancipatory utopias relevant to their own historically lived experiences. (shrink)

The main objective of this study is to understand the value of environmental, social, and governance (ESG) disclosure assurance in the context of the development of sustainable finance standards and laws. This study is based on an analysis of 188 comment letters submitted by such actors in the context of public consultations on the development of three new sustainable finance initiatives (the CFA Institute, the Financial Conduct Authority in the UK, and the New Zealand parliament). The study shows these actors' (...) nuanced and often quite critical perceptions of the effectiveness of external assurance in preventing greenwashing and their reservations about its mandatory nature. These actors have raised various criticisms, including concerns about the vagueness surrounding verification practices; the lack of expertise available to conduct assurance in a new, specialized, and complex field; the costs of the assurance process, particularly for small players; and the lack of control over the reliability of the ESG data used. This article contributes to several emerging trends in the literature—in particular, research on governance practices to prevent greenwashing, on the institutionalization of sustainable finance standards and laws, and on the role of rational myths in the assurance process for ESG disclosures. (shrink)

Ancien fleuron de l’industrie horlogère, Lip est une manufacture bisontine connue pour les conflits sociaux retentissants dont elle fut le théâtre en 1973-1974 puis en 1976-1977, et se dota très vite d’une aura légendaire à laquelle participèrent de nombreuses productions culturelles et artistiques contemporaines des événements. Le temps passant, l’intervention fit place à la rétrospection : de nouvelles œuvres s’employèrent à revisiter cette histoire, tendues entre le mythe et ses angles morts, la commémoration et le souvenir. Publiée en 1998, Les (...) Yeux rouges de Dominique Féret est l’une des premières à s’inscrire dans cet après-coup. Composée de quatre entretiens avec d’anciens protagonistes des luttes de Lip, cette pièce en dit au moins tout autant sur le passé que sur le présent qui se tourne vers lui et traduit l’inflexion que connaît tout un pan du théâtre européen des années 2000, marqué par la résurgence de la question sociale mais aussi par des modulations pathétiques qui tendent à sa dépolitisation. (shrink)

Despite being the primary homeland of Quebec's Inuit people, Nunavik's health care is typically planned and provided by non-Inuit newcomers. This retrospective case study investigates the effects of ethical leadership on the Westernized local Nunavik health care system's cultural sensitivity to its disproportionately Inuit populations. An integrative framework is developed that considers the dimensions of ethical leadership and the omnibus and discrete dimensions of context. This study shows that some Nunavik health care managers seek to improve and adapt the system (...) to the needs of their Inuit populations, while others do not. Unfortunately, the context restricts the former managers' ability to act consistently with their moral responsibilities and beliefs. Specifically, the findings show various institutional barriers to providing respectful and sensitive health care to Inuit. This study contributes to the scientific literature on ethical leadership by proposing an integrative conceptual framework. This framework illustrates how ethical leadership is inseparable from organizational context, identifying 16 contextual factors influencing managers' ethical behavior. Finally, three practical recommendations are proposed to highlight the omnibus and discrete context elements. (shrink)

This paper discusses a puzzle about philosophical beliefs. Core philosophical beliefs that are widely shared among philosophers, such as the belief that skepticism is false, are often held with extreme confidence. However, this confidence is not justified if these beliefs are based on what are traditionally seen as the sources of philosophical evidence, such as intuitions or observation (or reasoning on these bases). Charity requires that we should look for some other basis for these beliefs. I argue that these beliefs (...) are based on our knowledge of what we find interesting. Further, I argue that this is a good basis for belief. Knowing what we find interesting allows us to tune our inquiry in ways we could not otherwise. (shrink)

_ Metaepistemology _Edited by McHughConor, WayJonathan and WhitingDanielOxford University Press, 2018. viii + 216 pp.

Many criminal lawyers should expect that, were they to not defend a certain client, someone no less capable would do so. It is morally wrong for such attorneys to defend defendants who should be punished. This is true even if we grant that the defendant’s right to be defended outweighs any rights that might be infringed by the defense and that the benefits of defending are greater than the harm. Nor does this argument depend on any particular view of punishment. (...) The fact that the attorney expects to be replaced by someone equally capable has an asymmetric effect on the reasons for and against defending. The reasons that justify defending become extremely attenuated by this expectation, no matter what they are, while the reasons against defending are much less affected, no matter what they are. (shrink)

The Secord World War was a conflict which many British people feared might happen, but they strongly supported the efforts of Prime Minister Neville Chamberlain to seek a peaceful resolution of tensions with Germany over disputes in Continental Europe. Baptists in Scotland shared these concerns of their fellow citizens, but equally supported the declaration of war in 1939 after the German invasion of Poland. They saw the conflict as a struggle for spiritual values and were as concerned about winning the (...) peace that followed as well as the war. During the years 1939 to 1945 they recommitted themselves to sharing the Christian message with their fellow citizens and engaged in varied forms of evangelism and extended times of prayer for the nation. The success of their Armed Forces Chaplains in World War One ensured that Scottish Baptist padres had greater opportunities for service a generation later. Scottish Baptists had seen closer ties established with other churches in their country under the auspices of the Scottish Churches Council. This co-operation in the context of planning for helping refugees and engaging in reconstruction at the conclusion of the war led to proposals for a World Council of Churches. Scottish Baptists were more cautious about this extension of ecumenical relationships. In line with other Scottish Churches they recognised a weakening of Christian commitment in the wider nation, but were committed to the challenge of proclaiming their faith at this time. They had both high hopes and expectations for the post-war years in Scotland. (shrink)

Analysts often use data-driven approaches to supplement their knowledge when selecting covariates for effect estimation. Multiple variable selection procedures for causal effect estimation have been devised in recent years, but additional developments are still required to adequately address the needs of analysts. We propose a generalized Bayesian causal effect estimation algorithm to perform variable selection and produce double robust estimates of causal effects for binary or continuous exposures and outcomes. GBCEE employs a prior distribution that targets the selection of true (...) confounders and predictors of the outcome for the unbiased estimation of causal effects with reduced standard errors. The Bayesian machinery allows GBCEE to directly produce inferences for its estimate. In simulations, GBCEE was observed to perform similarly or to outperform DR alternatives. Its ability to directly produce inferences is also an important advantage from a computational perspective. The method is finally illustrated for the estimation of the effect of meeting physical activity recommendations on the risk of hip or upper-leg fractures among older women in the study of osteoporotic fractures. The 95% confidence interval produced by GBCEE is 61% narrower than that of a DR estimator adjusting for all potential confounders in this illustration. (shrink)

The prevalence of obesity skyrocketed over the past decades to become a significant public health problem. Obesity is recognized as a low-grade inflammatory disease and is linked with several comorbidities such as diabetes, circulatory disease, common neurodegenerative diseases, as well as chronic pain. Adipocytes are a major neuroendocrine organ that continually, and systemically, releases pro-inflammatory factors. While the exact mechanisms driving obesity-induced pain remain poorly defined, nociceptors hypersensitivity may result from the systemic state of inflammation characteristic of obesity as well (...) as weight surplus-induced mechanical stress. Obesity and pain also share various genetic mutations, lifestyle risk factors, and metabolic pathways. For instance, fat pads are often found hyper-innervated and rich in immune cell types of multiple origins. These immunocytes release cytokines, amplifying nociceptor function, which, in turn, via locally-released neuropeptides sustain immunocytes’ function. Here, we posit that along with mechanical stressed stemming from extra weight, the local neuro-immune interplay occurring within the fat pads maintains the state of chronic low-grade inflammation and heightens sensory hypersensitivity. Overall, stopping the harmful neuro-immune crosstalk may constitute a novel pathway to prevent obesity-associated comorbidities, including neuronal hypersensitivity. (shrink)