Results for 'lamina‐associated domains'

978 found
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  1.  22
    The Genomic Code: A Pervasive Encoding/Molding of Chromatin Structures and a Solution of the “Non‐Coding DNA” Mystery.Giorgio Bernardi - 2019 - Bioessays 41 (12):1900106.
    Recent investigations have revealed 1) that the isochores of the human genome group into two super‐families characterized by two different long‐range 3D structures, and 2) that these structures, essentially based on the distribution and topology of short sequences, mold primary chromatin domains (and define nucleosome binding). More specifically, GC‐poor, gene‐poor isochores are low‐heterogeneity sequences with oligo‐A spikes that mold the lamina‐associated domains (LADs), whereas GC‐rich, gene‐rich isochores are characterized by single or multiple GC peaks that mold the (...)
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  2.  28
    Many paths lead chromatin to the nuclear periphery.Molly R. Gordon, Benjamin D. Pope, Jiao Sima & David M. Gilbert - 2015 - Bioessays 37 (8):862-866.
    t is now well accepted that defined architectural compartments within the cell nucleus can regulate the transcriptional activity of chromosomal domains within their vicinity. However, it is generally unclear how these compartments are formed. The nuclear periphery has received a great deal of attention as a repressive compartment that is implicated in many cellular functions during development and disease. The inner nuclear membrane, the nuclear lamina, and associated proteins compose the nuclear periphery and together they interact with proximal chromatin (...)
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  3.  37
    Closing the (nuclear) envelope on the genome: How nuclear lamins interact with promoters and modulate gene expression.Philippe Collas, Eivind G. Lund & Anja R. Oldenburg - 2014 - Bioessays 36 (1):75-83.
    The nuclear envelope shapes the functional organization of the nucleus. Increasing evidence indicates that one of its main components, the nuclear lamina, dynamically interacts with the genome, including the promoter region of specific genes. This seems to occur in a manner that accords developmental significance to these interactions. This essay addresses key issues raised by recent data on the association of nuclear lamins with the genome. We discuss how lamins interact with large chromatin domains and with spatially restricted regions (...)
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  4.  39
    Segmental folding of chromosomes: A basis for structural and regulatory chromosomal neighborhoods?Elphège P. Nora, Job Dekker & Edith Heard - 2013 - Bioessays 35 (9):818-828.
    We discuss here a series of testable hypotheses concerning the role of chromosome folding into topologically associating domains (TADs). Several lines of evidence suggest that segmental packaging of chromosomal neighborhoods may underlie features of chromatin that span large domains, such as heterochromatin blocks, association with the nuclear lamina and replication timing. By defining which DNA elements preferentially contact each other, the segmentation of chromosomes into TADs may also underlie many properties of long‐range transcriptional regulation. Several observations suggest that (...)
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  5. Contrastes 11.Domaine Français Et la PassiviteItalien & I. Comprehension Et Interpretation - 1985 - Contrastes: Revue de l'Association Pour le Developpement des Études Contrastives 10:11.
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  6.  20
    Color associations in abstract semantic domains.Douglas Guilbeault, Ethan O. Nadler, Mark Chu, Donald Ruggiero Lo Sardo, Aabir Abubaker Kar & Bhargav Srinivasa Desikan - 2020 - Cognition 201 (C):104306.
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  7.  12
    Source Domain Associations as Conceptual Assemblages in Trauma Talk – an Association Rule Mining Approach.Dennis Tay & Han Qiu - 2024 - Metaphor and Symbol 39 (2):96-109.
    The qualitative nature of co-deployed or “associated” metaphorical source domains in discourse has been extensively researched, often in terms of whether they share common conceptual roots. There are however few empirical studies on the strength of these associations and their implications. In mental healthcare activities like psychological interviews and counseling, for example, strongly associated sources may suggest unique “conceptual assemblages” that highlight underexplored (dis)similarities between clients or client groups, beyond the typical focus on isolated sources and frequencies. Our case (...)
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  8.  46
    Cross-Domain Association in Metacognitive Efficiency Depends on First-Order Task Types.Alan L. F. Lee, Eugene Ruby, Nathan Giles & Hakwan Lau - 2018 - Frontiers in Psychology 9.
  9.  35
    Cross-Domain Associations Between Motor Ability, Independent Exploration, and Large-Scale Spatial Navigation; Attention Deficit Hyperactivity Disorder, Williams Syndrome, and Typical Development.Emily K. Farran, Aislinn Bowler, Annette Karmiloff-Smith, Hana D’Souza, Leighanne Mayall & Elisabeth L. Hill - 2019 - Frontiers in Human Neuroscience 13.
  10.  15
    Histoire des religions et destin de la théologie.Ernst Troeltsch, Jean-Marc Tâetaz, Pierre Gisel & Association Francophone Pour L'âedition Et la Diffusion de L'¶Uvre de Ernst Troeltsch Et Pour L'âetu - 1996 - Cerf.
    Théologien, historien, philosophe, sociologue et homme politique libéral, Ernst Troeltsch (1865-1923) fait partie du groupe des théologiens protestants allemands appelé " Ecole de l'histoire des religions ". Revendiquant l'héritage de Kant et de Schleiermacher, proche de Max Weber et du néo-kantisme de l'Ecole de Bade, Troeltsch est le théoricien classique du néo-protestantisme. Surtout connu en France comme sociologue de la religion, il est redécouvert aujourd'hui comme philosophe et théologien, éclipsé un temps par Barth, l'existentialisme et Heidegger. Les huit essais rassemblés (...)
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  11.  15
    Early number word learning: Associations with domain-general and domain-specific quantitative abilities.Meiling Yang & Junying Liang - 2022 - Frontiers in Psychology 13.
    Cardinal number knowledge-understanding “two” refers to sets of two entities-is a critical piece of knowledge that predicts later mathematics achievement. Recent studies have shown that domain-general and domain-specific skills can influence children’s cardinal number learning. However, there has not yet been research investigating the influence of domain-specific quantifier knowledge on children’s cardinal number learning. The present study aimed to investigate the influence of domain-general and domain-specific skills on Mandarin Chinese-speaking children’s cardinal number learning after controlling for a number of family (...)
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  12. Fictional domains.Dominic Gregory - 2024 - Noûs 58 (1):126-140.
    (Open Access.) Quantifiers frequently figure in works of fiction. But occurrences of quantificational expressions within fictions seem no more inevitably to be associated with real domains than uses of names within fictions seem inevitably to be associated with existing referents. The paper outlines some philosophical puzzles resulting from this apparent lack of associated domains, puzzles that are broadly analogous to more familiar ones raised by the apparently nonreferential nature of many fictional names. The paper argues, in the light (...)
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  13.  7
    Nuclear domain 10, the site of DNA virus transcription and replication.Gerd G. Maul - 1998 - Bioessays 20 (8):660-667.
    Within the highly organized nuclear structure, specific nuclear domains (ND10) are defined by accumulations of proteins that can be interferon-upregulated, implicating ND10 as sites of a nuclear defense mechanism.Compatible with such a mechanism is the deposition of herpesvirus, adenovirus, and papovavirus genomes at the periphery of ND10. However, these DNA viruses begin their transcription at ND10 and consequently initiate replication at these sites, suggesting that viruses have evolved ways to circumvent this potential cellular defense and exploit it. Other ND10-associated (...)
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  14.  23
    Character Strengths in the Life Domains of Work, Education, Leisure, and Relationships and Their Associations With Flourishing.Lisa Wagner, Lisa Pindeus & Willibald Ruch - 2021 - Frontiers in Psychology 12.
    A growing body of research demonstrates the relevance of character strengths for flourishing in general, but also for important outcomes across different life domains. Studies have also shown that there are differences in the extent to which character strengths are applied, that is, perceived as relevant and shown in behavior in a given context, between work and private life, but they have not considered other life domains. This study aims to close this gap by examining the life (...) of work, education, leisure, close personal relationships, and romantic relationships. The present study investigates whether strengths-related behavior across different life domains explains additional variance in flourishing beyond the trait level of each respective character strength and studies differences in the relevance of character strengths and strengths-related behavior across different life domains, and examines their relationships with flourishing. A sample of 203 German-speaking adults completed self-reports assessing flourishing and character strengths. They also indicated which of the five life domains were personally relevant to them and reported the character strengths' perceived relevance and the frequency of displaying strengths-related behavior for each of these life domains separately. The results demonstrate that strengths-related behavior averaged across all relevant life domains explained unique variance in flourishing above the trait-level of character strengths in some cases, different life domains were characterized by specific profiles of character strength—regarding both their relevance and strength-related behavior. Moreover, character strengths and strengths-related behavior in different life domains both showed substantial correlations with flourishing. In some cases, these associations were domain-specific. In conclusion, we suggest that examining strengths-related behavior across different life domains represents a worthwhile addition to research on character strengths. (shrink)
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  15.  13
    Domain Conditions in Social Choice Theory.Wulf Gaertner - 2001 - Cambridge University Press.
    Wulf Gaertner provides a comprehensive account of an important and complex issue within social choice theory: how to establish a social welfare function while restricting the spectrum of individual preferences in a sensible way. Gaertner's starting point is K. J. Arrow's famous 'Impossibility Theorem', which showed that no welfare function could exist if an unrestricted domain of preferences is to be satisfied together with some other appealing conditions. A number of leading economists have tried to provide avenues out of this (...)
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  16. Underdetermination, domain restriction, and theory choice.Mark Bowker - 2018 - Mind and Language 34 (2):205-220.
    It is often possible to know what a speaker intends to communicate without knowing what they intend to say. In such cases, speakers need not intend to say anything at all. Stanley and Szabó's influential survey of possible analysis of quantifier domain restriction is, therefore, incomplete and the arguments made by Clapp and Buchanan against Truth Conditional Compositionality and propositional speaker-meaning are flawed. Two theories should not always be viewed as incompatible when they associate the same utterance with different propositions, (...)
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  17.  31
    Musical Activity During Life Is Associated With Multi-Domain Cognitive and Brain Benefits in Older Adults.Adriana Böttcher, Alexis Zarucha, Theresa Köbe, Malo Gaubert, Angela Höppner, Slawek Altenstein, Claudia Bartels, Katharina Buerger, Peter Dechent, Laura Dobisch, Michael Ewers, Klaus Fliessbach, Silka Dawn Freiesleben, Ingo Frommann, John Dylan Haynes, Daniel Janowitz, Ingo Kilimann, Luca Kleineidam, Christoph Laske, Franziska Maier, Coraline Metzger, Matthias H. J. Munk, Robert Perneczky, Oliver Peters, Josef Priller, Boris-Stephan Rauchmann, Nina Roy, Klaus Scheffler, Anja Schneider, Annika Spottke, Stefan J. Teipel, Jens Wiltfang, Steffen Wolfsgruber, Renat Yakupov, Emrah Düzel, Frank Jessen, Sandra Röske, Michael Wagner, Gerd Kempermann & Miranka Wirth - 2022 - Frontiers in Psychology 13.
    Regular musical activity as a complex multimodal lifestyle activity is proposed to be protective against age-related cognitive decline and Alzheimer’s disease. This cross-sectional study investigated the association and interplay between musical instrument playing during life, multi-domain cognitive abilities and brain morphology in older adults from the DZNE-Longitudinal Cognitive Impairment and Dementia Study study. Participants reporting having played a musical instrument across three life periods were compared to controls without a history of musical instrument playing, well-matched for reserve proxies of education, (...)
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  18.  18
    Prospective association between standing balance and cognitive function in middle-aged and older Chinese adults.Jingzheng Yan, Fangyun Luan, Meijuan Wang, Wenshuo Dong, Xinyue Zhang, Mengli Li & Yingjuan Cao - 2022 - Frontiers in Psychology 13.
    ObjectiveTo investigate the association of standing balance with cognitive functions and the rate of cognitive decline among middle-aged and older Chinese adults.MethodsParticipants were selected from China’s Health and Retirement Longitudinal Study. A total of 8,499 subjects aged ≥45 years who participated in wave 1 to wave 3 surveys were included in the final analysis. Standing balance was measured using the tandem test, and participants were categorized into two groups according to their ability to maintain standing balance. Cognitive functions were assessed (...)
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  19.  40
    Decision-making competence predicts domain-specific risk attitudes.Joshua A. Weller, Andrea Ceschi & Caleb Randolph - 2015 - Frontiers in Psychology 6:139420.
    Decision Making Competence (DMC) reflects individual differences in rational responding across several classic behavioral decision-making tasks. Although it has been associated with real-world risk behavior, less is known about the degree to which DMC contributes to specific components of risk attitudes. Utilizing a psychological risk-return framework, we examined the associations between risk attitudes and DMC. Italian community residents (n = 804) completed an online DMC measure, using a subset of the original Adult-DMC battery (A-DMC; Bruine de Bruin, Parker, & Fischhoff, (...)
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  20.  86
    Association by movement: evidence from NPI-licensing. [REVIEW]Michael Wagner - 2006 - Natural Language Semantics 14 (4):297-324.
    ‘Only’ associates with focus and licenses NPIs. This paper looks at the distributional pattern of NPIs under ‘only’ and presents evidence for the movement theory of focus association and against an in situ approach. NPIs are licensed in the ‘scope’ (or the second argument) of ‘only’, but not in the complement (or its first argument), which I will call the ‘syntactic restrictor’. While earlier approaches argued that ‘only’ licenses NPIs in the unfocused part of the sentence it occurs in except (...)
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  21.  14
    Associations of Changes in Religiosity With Flourishing During the COVID-19 Pandemic: A Study of Faith Communities in the United States.Christopher Justin Jacobi, Richard G. Cowden & Brandon Vaidyanathan - 2022 - Frontiers in Psychology 13.
    This study explored the extent to which perceived changes in religiosity from before to during the COVID-19 pandemic are associated with flourishing. Participants from a diverse set of faith communities in two United States metropolitan regions completed an online survey between October and December 2020. The survey included items capturing perceived changes in four dimensions of religiosity and a multidimensional measure of flourishing. Based on multilevel regressions, results indicated that self-reported decreases in each dimension of religiosity were associated with lower (...)
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  22.  12
    Disruption of regulatory domains and novel transcripts as disease‐causing mechanisms.Lila Allou & Stefan Mundlos - 2023 - Bioessays 45 (10):2300010.
    Deletions, duplications, insertions, inversions, and translocations, collectively called structural variations (SVs), affect more base pairs of the genome than any other sequence variant. The recent technological advancements in genome sequencing have enabled the discovery of tens of thousands of SVs per human genome. These SVs primarily affect non‐coding DNA sequences, but the difficulties in interpreting their impact limit our understanding of human disease etiology. The functional annotation of non‐coding DNA sequences and methodologies to characterize their three‐dimensional (3D) organization in the (...)
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  23.  15
    Factors associated with academic resilience in disadvantaged students: An analysis based on the PISA 2015 B-S-J-G (China) sample.Songli Jin, Guangbao Fang, Kwok Cheung Cheung & Pou Seong Sit - 2022 - Frontiers in Psychology 13.
    Academic resilience is evident in students who are living in vulnerable environments, yet achieve success in academic outcomes. As a result, substantial attention has been devoted to identifying the factors associated with academic resilience and supporting students to be resilient. This study used the Classification and Regression Tree and Multilevel Logistic Regression modeling to identify the potential factors related to students’ academic resilience. Using these tools, the study analyzed the B-S-J-G sample in PISA 2015. The variables that significantly predicted whether (...)
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  24.  59
    Why Some Foci Must Associate.Roger Schwarzschild - unknown
    The association of only with focus is explained in terms of (a) a semantics for only which makes no mention of focus and (b) discourse appropriateness conditions on the use of focus and principles of quantifier domain selection. This account differs from previous ones in giving sufficient conditions for association with focus but without stipulating it in the meaning of lexical items. Detractors have contended that foci have different pragmatic import depending on whether or not they are associated with a (...)
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  25. Association mechanisms and the intentionality of the mental.Mark Stephen Pestana - 2006 - Journal of Mind and Behavior 27 (2):91-120.
    This paper is an explanation of how the intentionality of perception is due to specific associations of sensations. It describes the intentionality of the mental and the problem that intentionality poses for accounts of the mind. The concept of "direction of fit" or "fulfillment of the act" is central to this description. An amalgamation of various recent interpretations of intentionality into a unified theory is presented along with an account of why even such a unified theory fails to account for (...)
     
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  26.  42
    Trivializing modularity. An associative-representational account of cognition.Marco Mazzone - 2016 - Epistemologia (2):201-215.
    In the present paper I analyse the modularity thesis and, more specifically, the thesis of domain-specificity of processing. I argue that this thesis is not trivial only under the assumption of a variety of processes which differ from each other at the implementation level; otherwise, the variety of cognitive processes can only be explained as emergent on the basic mechanism of associative activation in that it operates on domain-specific representations, which is something that no one would deny. But that assumption (...)
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  27. Multiple-domain supervenience for non-classical mereologies.Ralf M. Bader - 2016 - In Ralf Bader (ed.), Ontological Dependence and Supervenience. Philosophia.
    This paper develops co-ordinated multiple-domain supervenience relations to model determination and dependence relations between complex entities and their constituents by appealing to R-related pairs and by making use of associated isomorphisms. Supervenience relations are devised for order-sensitive and repetition-sensitive mereologies, for mereological systems that make room for many-many composition relations, as well as for hierarchical mereologies that incorporate compositional and hylomorphic structure. Finally, mappings are provided for theories that consider wholes to be prior to their parts.
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  28.  28
    Lithbea, a New Domain Outside the Tree of Life.Jaime Gómez-Márquez - 2023 - Global Philosophy 33 (1):1-19.
    At this time when the development of synthetic biology and artificial intelligence are changing the world around us, philosophers and scientists, first of all, must converge to analyze the present and predict the ethical-social consequences and biological dangers associated with new “living entities” that are not the result of the natural evolutionary process. As synthetic/artificial life forms (xenobots, robots, transgenic organisms, etc.) become more and more abundant and sophisticated, it seems first of all necessary to bring some order to all (...)
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  29.  14
    Associations Between Sign Language Skills and Resting-State Functional Connectivity in Deaf Early Signers.Emil Holmer, Krister Schönström & Josefine Andin - 2022 - Frontiers in Psychology 13:738866.
    The processing of a language involves a neural language network including temporal, parietal, and frontal cortical regions. This applies to spoken as well as signed languages. Previous research suggests that spoken language proficiency is associated with resting-state functional connectivity (rsFC) between language regions and other regions of the brain. Given the similarities in neural activation for spoken and signed languages, rsFC-behavior associations should also exist for sign language tasks. In this study, we explored the associations between rsFC and two types (...)
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  30.  35
    Longitudinal associations between children's understanding of emotions and theory of mind.Marion O'Brien, Jennifer Miner Weaver, Jackie A. Nelson, Susan D. Calkins, Esther M. Leerkes & Stuart Marcovitch - 2011 - Cognition and Emotion 25 (6):1074-1086.
    Theory of mind competence and knowledge of emotions were studied longitudinally in a sample of preschoolers aged 3 (n=263) and 4 (n=244) years. Children were assessed using standard measures of theory of mind and emotion knowledge. Three competing hypotheses were tested regarding the developmental associations between children's theory of mind abilities and their knowledge of emotions. First, that an understanding of emotion develops early and informs children's understanding of others’ thinking. Alternatively, having a basic theory of mind may help children (...)
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  31.  73
    The Association Between Metabolic Disturbance and Cognitive Impairments in Early-Stage Schizophrenia.Xing-Jie Peng, Gang-Rui Hei, Ran-Ran Li, Ye Yang, Chen-Chen Liu, Jing-Mei Xiao, Yu-Jun Long, Ping Shao, Jing Huang, Jing-Ping Zhao & Ren-Rong Wu - 2021 - Frontiers in Human Neuroscience 14:599720.
    Background: Cognitive impairment is one of the core symptoms of schizophrenia, which is considered to be significantly correlated to prognosis. In recent years, many studies have suggested that metabolic disorders could be related to a higher risk of cognitive defects in a general setting. However, there has been limited evidence on the association between metabolism and cognitive function in patients with early-stage schizophrenia.Methods: In this study, we recruited 172 patients with early-stage schizophrenia. Relevant metabolic parameters were examined and cognitive function (...)
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  32.  30
    How to classify domain entities into top-level ontology concepts using large language models.Alcides Lopes, Joel Carbonera, Fabricio Rodrigues, Luan Garcia & Mara Abel - 2024 - Applied ontology:1-29.
    Classifying domain entities into their respective top-level ontology concepts is a complex problem that typically demands manual analysis and deep expertise in the domain of interest and ontology engineering. Using an efficient approach to classify domain entities enhances data integration, interoperability, and the semantic clarity of ontologies, which are crucial for structured knowledge representation and modeling. Based on this, our main motivation is to help an ontology engineer with an automated approach to classify domain entities into top-level ontology concepts using (...)
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  33.  25
    Subtelomeres as Specialized Chromatin Domains.Antoine Hocher & Angela Taddei - 2020 - Bioessays 42 (5):1900205.
    Specificities associated with chromosomal linearity are not restricted to telomeres. Here, recent results obtained on fission and budding yeast are summarized and an attempt is made to define subtelomeres using chromatin features extending beyond the heterochromatin emanating from telomeres. Subtelomeres, the chromosome domains adjacent to telomeres, differ from the rest of the genome by their gene content, rapid evolution, and chromatin features that together contribute to organism adaptation. However, current definitions of subtelomeres are generally based on synteny and are (...)
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  34.  31
    An associative account of inferences: The development towards the prototype.Marco Mazzone - 2021 - Rivista Internazionale di Filosofia e Psicologia 12 (1):1-15.
    : According to a traditional view, inferences are personal-level entities pertaining to the domain of reasons, and therefore they cannot be accounted for in causal terms – specifically, as mere associations. I intend to argue that this is at the very least a drastic simplification, for two reasons. First, the word “association” is polysemous, so we should specify in which of its possible senses an inference is not a mere association. Second, personal-level inferences based on formal rules are only the (...)
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  35.  93
    Vagueness and domain restriction.Peter Pagin - unknown
    This paper develops an idea of saving ordinary uses of vague predicates from the Sorites by means of domain restriction. A tolerance level for a predicate, along a dimension, is a difference with respect to which the predicate is semantically insensitive. A central gap for the predicate+dimension in a domain is a segment of an associated scale, larger than this difference, where no object in the domain has a measure, and such that the extension of the predicate has measures on (...)
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  36.  23
    Structural and functional domains of tubulin.Ricardo B. Maccioni, Luis Serrano & Jesus Avila - 1985 - Bioessays 2 (4):165-169.
    The molecular aspects of the microtubule system is a research area that has developed very rapidly during the past decade. Research on the assembly mechanisms and chemistry of tubulin and the molecular biology of microtubules have advanced our understanding of microtubule formation and its regulation. The emerging view of tubulin is of a macromolecule containing spatially discrete sequences that constitute functionally different domains with respect to self‐association, interactions with microtubule associated proteins (MAPs) and specific ligands. Recent studies point to (...)
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  37.  43
    Are there domain–specific thinking skills?Gerald Smith - 2002 - Journal of Philosophy of Education 36 (2):207–227.
    Adopting a much broader notion of thinking than that associated with the Critical Thinking movement, this paper addresses the question of thinking skill generality. An analysis of the concept of ‘thinking skill’ suggests ways in which this notion has been misapplied. The paper demonstrates the importance of thinking tasks and argues for a non–universalistic notion of thinking skill generality. The domains–view of thinking is assessed, evidence from secondary research being used to show that thinking skills are not domain–specific simply (...)
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  38. The undeflated domain of semantics Paul M. Pietroski, university of maryland.Paul Pietrowski - manuscript
    It is, I suppose, a truism that an adequate theory of meaning for a natural language L will associate each sentence of L with its meaning. But the converse does not hold. A theory that associates each sentence with its meaning is not, by virtue of that fact, an adequate theory of meaning. For it is also a truism that a semantic theory should explain the (interesting and explicable) semantic facts. And one cannot decree that the relevant facts are all (...)
     
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  39.  24
    Spatializing Emotion: No Evidence for a Domain‐General Magnitude System.Benjamin Pitt & Daniel Casasanto - 2018 - Cognitive Science 42 (7):2150-2180.
    People implicitly associate different emotions with different locations in left-right space. Which aspects of emotion do they spatialize, and why? Across many studies people spatialize emotional valence, mapping positive emotions onto their dominant side of space and negative emotions onto their non-dominant side, consistent with theories of metaphorical mental representation. Yet other results suggest a conflicting mapping of emotional intensity (a.k.a., emotional magnitude), according to which people associate more intense emotions with the right and less intense emotions with the left (...)
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  40.  15
    Dynamic organisation of intermediate filaments and associated proteins during the cell cycle.Roland Foisner - 1997 - Bioessays 19 (4):297-305.
    Intermediate filaments, which form the structural framework of both the cytoskeleton and the nuclear lamina in most eukaryotic cells, have been found to be highly dynamic structures. A continuous exchange of subunit proteins at the filament surface and a stabilisation of soluble subunits by chaperone‐type proteins may modulate filament structure and plasticity. Recent studies on the cell cycle‐dependent interaction of intermediate filaments with associated proteins, and a detailed analysis of intermediate filament phosphorylation in defined subcellular locations at various stages of (...)
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  41.  41
    Broad Chromatin Domains: An Important Facet of Genome Regulation.Francesco N. Carelli, Garima Sharma & Julie Ahringer - 2017 - Bioessays 39 (12):1700124.
    Chromatin composition differs across the genome, with distinct compositions characterizing regions associated with different properties and functions. Whereas many histone modifications show local enrichment over genes or regulatory elements, marking can also span large genomic intervals defining broad chromatin domains. Here we highlight structural and functional features of chromatin domains marked by histone modifications, with a particular emphasis on the potential roles of H3K27 methylation domains in the organization and regulation of genome activity in metazoans. Chromatin (...) are extended genomic regions defined by the continuous enrichment of a given histone modification. Here, we review recent work highlighting the presence of chromatin domains in multiple species, their structural aspects in the context of chromatin architecture, and their potential role on the regulation of genome activity. (shrink)
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  42.  11
    Les associations évoquées par les mots : collecte, analyse, exploitation1.Michèle Debrenne - 2020 - Corela. Cognition, Représentation, Langage 18.
    Cet article présente l’état des lieux dans un domaine insuffisamment représenté en linguistique française, les dictionnaires d’associations évoquées par les mots. Seront présentés les principes sur lesquels ces dictionnaires sont construits, la méthodologie, les résultats et leur exploitation. Établis d’après les résultats d’enquêtes psycholinguistiques de fixation de la première réponse à un stimulus donné, ces dictionnaires se présentent sous deux formes – le dictionnaire direct, comportant les réactions classées par ordre de fréquence, et le dictionnaire inverse, dans lequel le mot (...)
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  43.  23
    Demand and Supply: Association between Pediatric Ethics Consultation Volume and Protected Time for Ethics Work.Meaghann S. Weaver, Christopher Wichman, Shiven Sharma & Jennifer K. Walter - 2023 - AJOB Empirical Bioethics 14 (3):135-142.
    Background Despite national increase in pediatric ethics consultation volume over the past decade, protected time and resources for healthcare ethics consultancy work has lagged.Methods Correlation study investigating potential associations between ethics consult volume reported by recent national survey of consultants at children’s hospitals and five programmatic domains.Results 104 children’s hospitals in 45 states plus Washington DC were included. There was not a statistically significant association between pediatric ethics consult volume and hospital size, rurality of patient population, or number of (...)
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  44.  15
    Maximizing Without Borders: Evidence That Maximizing Transcends Decision Domains.Michail D. Kokkoris - 2019 - Frontiers in Psychology 9:425701.
    Do maximizers maximize across decision domains? An assumption underlying the literature on maximizing is that the tendency to strive to make the best choice spans domains. The current research provides a direct test of this assumption by examining the association between trait maximizing and domain-specific maximizing, consisting of maximizing measures in a wide range of decisions (consumer goods, services and experiences, and life decisions). Study 1 tested this association at two different time points in order to minimize common (...)
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  45.  43
    Association but not Recognition: an Alternative Model for Differential Imitation from 0 to 2 Months.Stefano Vincini & Yuna Jhang - 2018 - Review of Philosophy and Psychology 9 (2):395-427.
    Skepticism toward the existence of neonatal differential imitation is fostered by views that assign it an excessive significance, making it foundational for social cognition. Moreover, a misleading theoretical framework may generate unwarranted expectations about the kinds of findings experimentalists are supposed to look for. Hence we propose a theoretical analysis that may help experimentalists address the empirical question of whether early differential imitation really exists. We distinguish three models of early imitation. The first posits automatic visuo-motor links evolved for sociocognitive (...)
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  46.  36
    (1 other version)The emerging domain of the political.David M. Rasmussen - 2012 - Philosophy and Social Criticism 38 (4-5):457-466.
    This essay deals with two conceptions of the political, one that entails a clash of civilizations associated with a Schmittian critique of liberalism and a second which envisions the political as an emerging domain. The latter idea can be associated with the later work of John Rawls which separates the comprehensive from the political. I argue that it is this idea, when reconstructed in relationship to a theory of multiple modernities, that can be appropriated for an emerging notion of global (...)
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  47.  67
    Analogical associations in the frame of a “neoclassical” semiotic theory.Guido Ferraro - 2010 - Sign Systems Studies 38 (1/4):67-89.
    It has been a long time since the concept of iconic signs was proposed by C. S. Peirce. From that time on, we have been increasingly realizing that semiotic systems are for the most part established just on some type of similarity. But the more we see the sphere of analogical signification expanding its realm, themore we become aware of how inadequate is the notion of a simple relationship connecting locally a physical object with a second object, or with a (...)
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  48.  22
    PDZ Domains: Targeting signalling molecules to sub‐membranous sites.Christopher P. Ponting, Christopher Phillips, Kay E. Davies & Derek J. Blake - 1997 - Bioessays 19 (6):469-479.
    PDZ (also called DHR or GLGF) domains are found in diverse membraneassociated proteins including members of the MAGUK family of guanylate kinase homologues, several protein phosphatases and kinases, neuronal nitric oxide synthase, and several dystrophin‐associated proteins, collectively known as syntrophins. Many PDZ domain‐containing proteins appear to be localised to highly specialised submembranous sites, suggesting their participation in cellular junction formation, receptor or channel clustering, and intracellular signalling events. PDZ domains of several MAGUKs interact with the C‐terminal polypeptides of (...)
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  49. The Association Between Ethical Conflict and Adverse Outcomes.Linda Thorne - 2010 - Journal of Business Ethics 92 (2):269-276.
    In this study, we consider the association between ethical conflict and adverse outcomes, including employee stress, (lack of) organizational commitment, absenteeism, and turnover intention. Our findings show that ethical conflict is associated with adverse outcomes. Our results identify the importance of ethical conflict for organizations and the benefit for organizations to address and mitigate ethical conflict. In addition, our research contributes to the person–organization and turnover literature by extending the person-fit framework to the ethical domain and by suggesting that ethical (...)
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  50.  50
    Darwinian Domain-Generality: The Role of Evolutionary Psychology in the Modularity Debate.Michael Lundie - unknown
    Evolutionary Psychology (EP) tends to be associated with a Massively Modular (MM) cognitive architecture. I argue that EP favors a non-MM cognitive architecture. The main point of dispute is whether central cognition, such as abstract reasoning, exhibits domain-general properties. Partisans of EP argue that domain-specific modules govern central cognition, for it is unclear how the cognitive mind could have evolved domain-generality. In response, I defend a distinction between exogenous and endogenous selection pressures, according to which exogenous pressures tend to select (...)
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