The article deals with the influence of organizational ethics program components on managerial ethical behavior. The main aim was to establish which EP components are perceived as valuable and useful to foster the ethical behavior of managers. Moreover, we also aimed to investigate the role of ethics training in this context and to explore whether it can potentially increase managers’ trust in EP components as effective tools for the promotion of ethical behavior. The article advances the EP theory in several (...) ways. It offers novel insights into both business ethics and EP development in the specific cultural and social circumstances of a former socialist country in the Central and Eastern European region, Slovakia. It shows that codes of ethics and related reporting and control mechanisms are perceived as the most effective EP components to shape managerial ethical behavior. Furthermore, based on empirical evidence, and to some extent contrary to prior theory, the article unveils three EP functions, namely the ‘compliance with group norms,’ the ‘ethics education through collective discussion,’ and the ‘counselling and resolving of ethical issues’ at workplace. In addition, the article shows that ethics trainings can help to boost the trust of managers toward EP components and might be conceptualized as a precursor for an effectively functioning EP. (shrink)

This paper presents the link between Arthur N. Prior and logicians that belonged to the Lvov-Warsaw School. Although certain members of the Lvov-Warsaw School influenced Prior’s views, the amount and the form of the impact are still under discussion. Prior also cooperated with some of them in the development of his systems of logic. This paper focuses on four main areas in which Prior admitted adopting ideas from the Lvov-Warsaw School: systems of propositional logic, the history of logic, modal and (...) temporal logic and ontology. Prior’s published works as well as his correspondence, which is stored in Prior’s Nachlass, are used to describe the influence. (shrink)

In September 2007, more than 100 philosophers came to Prague with the determination to approach Karl Popper's philosophy as a source of inspiration in many areas of our intellectual endeavor. This volume is a result of that effort.

Pharmacists who refuse to provide certain services or treatment for reasons of conscience have been criticized for failing to fulfil their professional obligations. Currently, individual pharmacists in Great Britain can withhold services or treatment for moral or religious reasons, provided they refer the patient to an alternative source. The most high-profile cases have concerned the refusal to supply emergency hormonal contraception, which will serve as an example in this article.I propose that the pharmacy profession's policy on conscientious objections should be (...) altered slightly. Building on the work of Brock and Wicclair, I argue that conscientious refusals should be acceptable provided that the patient is informed of the service, the patient is redirected to an alternative source, the refusal does not cause an unreasonable burden to the patient, and the reasons for the refusal are based on the core values of the profession. Finally, I argue that a principled categorical refusal by an individual pharmacist is not morally permissible. I claim that, contrary to current practice, a pharmacist cannot legitimately claim universal exemption from providing a standard service, even if that service is available elsewhere. (shrink)

Although Łukasiewicz and Quine do not share many common views, they agreed on one important point in the 1950s: they both denied the distinction between empirical and a priori sciences. This agreement might be surprising as this denial was rather controversial at that time. This paper focuses on Quine’s and Łukasiewicz’s denials of the distinction between empirical and a priori sciences, and proposes three possible answers to the question of why both formulated the same conclusion at a similar time. Firstly, (...) it discusses Quine’s possible influence on Łukasiewicz as Łukasiewicz agreed with Quine’s criticism of modality at that time. Secondly, it considers the possibility that Quine was affected by Łukasiewicz via his debates with Łukasiewicz’s student, Tarski. Lastly, it takes into account the possibility that both philosophers were inspired by an external source, namely the rise of quantum mechanics. (shrink)

Two main tendencies in postmodernism can be identified, neither providing much scope for developing a postmodern philosophy of science. According to the first, the world is fragmented into a plurality of autonomous local discourses, implying that any advice to scientists can be given only from within science and not from philosophers who stand outside ( above') science. According to the second, the meaning of signs is fundamentally elusive (poststructuralism and deconstruction). A deconstructive philosophy of science might be conceived of as (...) experimenting with scientific texts, but in that case the label philosophy' becomes a mere matter of convention. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Against the Spirit of Foundations: Postmodernism and David Hume1 Zuzana Parusnikova Introduction David Hume lived at the very dawn ofthe modern age and belonged to the Scottish Enlightenment. The Enlightenment is often conceived of as the essence of modernity, thus standing in firm opposition to postmodernism. According to postmodernists, the Enlightenmentideal of a universal liberating rationality and the principle of universally shared norms ofhumanism have not only lost (...) their vigour and appeal, but have proved to be oppressive and downright authoritarian. The project of the Enlightenment should thus be abandoned. And yet, despite the fact that Hume chronologically belonged to modernity, I find striking similarities between his views and postmodernism. Over the years there have been many, typically modern, efforts to find some unity and to grasp the essence of Hume's philosophy, to provide some general interpretative angle by which it can appear as a consistent philosophical system. I want to argue that such an approach is neither necessary nor desirable because it deprives Hume's philosophy of its most appealing feature—his acceptance of and tolerance towards the irreconcilability of its sceptical and natural elements. There is no need to force Hume to fit neatly under any traditional philosophical label.2 The permanent inconsistency in his 'system' resulting from his firm anti-foundationalist attitude is not a defect but instead makes his philosophy far more intriguing. The disunity which can be found in Hume's texts is also the feature bringing him close to postmodernism. Postmodernism is a fuzzy area, difficult to approach let alone to define. It deliberately avoids defining itself and could even be seen as "the characteristic of a universe where there are no more definitions possible." 3 Postmodernism is not a homogeneous stage of thinking following after modernism (as the prefix 'post' misleadingly suggests), but rather deconstructs modernity without offering a new and coherent alternative. Therefore, paradoxically, while deconstructing we have to use thevocabularywhichis being deconstructed and cannotcompletely avoid the ' logos ofthe definition'. This feature is reflected in what Derrida calls 'writing under erasure': we write and erase at the same time—since our language is constructed upon the modern logocentrism, we have no choice but to Volume XLX Number 1 ZUZANA PARUSNIKOVA use it. As a result, interpreting the meaning of texts, although authoritarian in its original intention, reveals the illusory character of any ultimate interpretation. Texts are viewed as mysterious and confusinglabyrinths,bycontrasttothemodernobsession aboutclarity, precision, consistency and the possibility of decoding the exact, fundamental message they convey. Philosophy is no longer conceived ofas a questfor foundations, and philosophical texts are looked at from a new perspective: they are rather 'misread', 'misinterpreted' or read on the margins' in order to paralyse the oppressive interpretations seeking some foundational interpretative principle and imposing compulsory norms ofunderstanding.4 Hume's philosophy has suffered extensive abuse of this foundationalist kind. With rare exceptions (for example, Richard Popkin), most interpreters have tried to eliminate the inconsistencies and contradictions in his writings and to pigeon-hole him victoriously. But Hume has given them a hard time indeed. The reason he has been such a poser is, in my opinion, that he—like postmodernists—does not offer any foundationalist perspective. In fact, their firm antifoundationalism makes allies ofhim and postmodernists. Anti-foundationalism For postmodernism, philosophy ceases to enjoy its traditional privilege of being a foundationalist discipline in either a metaphysical or an epistemological sense. Philosophy does not reveal any hidden depths, any deeper truths. It does not provide any unique insights guiding us beyond the immense diversity ofthe world towards its essential unity (metaphysics), nor does itprovide anyepistemological clue tothe world. Philosophy is denied the function of an epistemological police organizing the world into a well-arranged, easily-surveyed picture. For postmodernists, this modern "fantasy to seize reality"and makeitfully transparent and communicable is a source of terror.5 Postmodernism views the desire to master reality as leading to intellectual dictatorship, by eliminating the relevance and the rights ofthe other" which does not conform to modern principles and is thus downgraded in the modern hierarchy. The theoretical core ofthis anti-foundationalism, in my opinion, is the poststructuralist theory of meaning, developing the structuralist view (of Saussure) that meaning is never... (shrink)

In his paper ‘The logic of temporal discourse’, Pavel Tichý pointed out that contemporary systems of logic were unable to sufficiently formalise tenses. He therefore suggested temporal specification in transparent intensional logic (TIL), a system of logic that he developed. Discussing contemporary systems of logic, Tichý also took into account the system of Arthur N. Prior, who developed the first systems of modern temporal logic, and his criticism was also addressed to Prior. Tichý only focused, however, on Prior’s early systems (...) of temporal logic. Patrick Blackburn recently raised the awareness that Prior also developed systems of hybrid logic in his latest periods. From the point of view of temporal specification, this system is particularly interesting as the system has greater expressive power than Prior’s early systems of temporal logic. It could also consequently deal with the problematic specifications of tenses that Pavel Tichý pointed out. It is not only the formal criterion that make Tichý and Prior’s approach suitable for comparison. Both logicians shared similar views on time and logic. All these convictions also influenced their systems of logic. The aim of this paper is to demonstrate that the temporal propositions that Tichý introduced as problematic could be formalised in Prior’s hybrid temporal logic. I will also compare formalisations in TIL and hybrid logic and Tichý and Prior’s views that influenced their systems of logic. (shrink)

Recent scientific advances mean the widespread introduction of non-invasive prenatal diagnosis (NIPD) for chromosomal aneuploidies may be close at hand, raising the question of how NIPD should be introduced as part of antenatal care pathways for pregnant women. In this paper, the authors examine the ethical implications of three hypothetical models for using NIPD for aneuploidy in state-funded healthcare systems and assess which model is ethically preferable. In comparing the models, the authors consider their respective timings; how each model would (...) fit with current screening and diagnostic tests offered to pregnant women; the implications of offering NIPD at different stages of pregnancy; and the potential for each model to support reproductive autonomy and informed decision-making. The authors conclude by favouring a model that would be offered at 11–13 weeks gestation, alongside existing combined screening, provided that this is accompanied by measures to maximise informed decision-making, for example, provision of adequate pretest and post-test counselling. (shrink)

This article argues that intersectional analyses of care work also need to include a temporal aspect. Drawing on ethnographic research on Slovak au pairs working in the UK and on interviews with both providers and employers of paid childcare in Slovakia, I examine how the temporariness of care work is created within both migrant and non-migrant settings. In particular, I demonstrate that both employers and providers conceptualise paid childcare as a temporary period in their lives and show the consequences of (...) this conceptualisation in their valuing of care work. In both examined cases, I focus on the role of care/welfare and migration regimes in the production of temporariness in care work and argue that both providers and employers of paid care construct their involvement in domestic work as a specific life course experience. While for au pairs, working stays in the UK represent a specific transition period from adolescence to adulthood, employers in Slovakia decide to employ particular types of domestic workers in relation to the particular developmental phases of their families and households. (shrink)

Propositional fuzzy logics given by a combination of a continuous SBL t-norm with finitely many idempotents and of an involutive negation are investigated. A characterization of continuous t-norms which, in combination with different involutive negations, yield either isomorphic algebras or algebras with distinct and incomparable sets of propositional tautologies is presented.

Jan Łukasiewicz is known primarily as the founder of the three-valued system of logic. It is also generally renowned that his reason for introducing many-valued systems of logic was an attempt to refute determinism. When he developed the three-valued and n-valued logic, he employed these systems in his arguments against determinism. On the contrary, Łukasiewicz preferred the four-valued system of logic that is not suitable for a refutation of determinism in his latest period. It seems, however, that determinism still interested (...) Łukasiewicz, as he discussed its denial in his last work, the second edition of the book Aristotle’s syllogistic from the standpoint of modern formal logic. The aim of my paper is to introduce the issue and describe the relation of these two topics primarily in the latest period of Łukasiewicz’s work. There are several possible solutions to the issue. However, Łukasiewicz never addressed the issue clearly in his published works. Therefore, the solutions might be supported or contradicted by his unpublished works in the future. (shrink)

What is education? What options does the educator have and what is expected from those who are being educated? What do education in the sense of paideia and the Christian educatio have in common? And what is the difference between those two notions? What does it mean to succeed in the drama of life and the world? Can the insightful (theoria) seeking of wisdom (sofia, sapientia) be separated from the effective (praxis) seeking of reason (fronésis, prudentia)? What is the purpose (...) of scholé and can it be experienced in schools today? How do today's schools prepare the youngest generation for the task of enhancing civil society? Is everyone able to relate to good? What does it mean to testify to the idea of good? These and other questions are asked in a dialogue of two teachers from the Czech Republic and Slovakia, respectively, who are concerned with philosophy, theology and pedagogy. The aim of the dialogue is to enter the Living school of thought, as founded by the Czech philosopher Radim Palouš (1924–2015), and to consider anew the topics he opened in his works. The dialogue embarks on a journey of searching for wisdom, by listening to words and the Word, by perceiving and contemplating experience, through reason and intuition, dialogue and acceptance in silence. It involves taking a closer look into the world that concerns everyone who are pupils, students, educators, teachers, educators – those who seek and who are sent, those longing and facing misunderstanding. It is an invitation to reflect on human life with humility and the awareness of human responsibility, in the hope that the pursuit of good, truth and beauty is intertwined with the task of succeeding as humans. (shrink)

Non-invasive prenatal testing is an emerging form of prenatal genetic testing that provides information about the genetic constitution of a foetus without the risk of pregnancy loss as a direct result of the test procedure. As with other prenatal tests, information from NIPT can help to make a decision about termination of pregnancy, plan contingencies for birth or prepare parents to raise a child with a genetic condition. NIPT can also be used by women and couples to test purely ‘for (...) information’. Here, no particular action is envisaged following the test; it is motivated entirely by an interest in the result. The fact that NIPT can be performed without posing a risk to the pregnancy could give rise to an increase in such requests. In this paper, we examine the ethical aspects of using NIPT ‘purely for information’, including the competing interests of the prospective parents and the future child, and the acceptability of testing for ‘frivolous’ reasons. Drawing on several clinical scenarios, we claim that arguments about testing children for genetic conditions are relevant to this debate. In addition, we raise ethical concerns over the potential for objectification of the child. We conclude that, in most cases, using NIPT to test for adult-onset conditions, carrier status or non-serious traits presenting in childhood would be unacceptable. (shrink)

Empirical evidence suggests that some health professionals believe consent procedures for the emerging technology of non-invasive prenatal diagnosis (NIPD) should become less rigorous than those currently used for invasive prenatal testing. In this paper, we consider the importance of informed consent and informed choice procedures for protecting autonomy in those prenatal tests which will give rise to a definitive result. We consider whether there is anything special about NIPD that could sanction a change to consent procedures for prenatal diagnosis or (...) otherwise render informed decision-making less important. We accept the claim that the absence of risk of miscarriage to some extent lessens the gravity of the decision to test compared with invasive methods of testing. However, we also claim that the definitive nature of the information received, and the fact that the information can lead to decisions of great significance, makes NIPD an important choice. This choice should only be made by means of a rigorous and appropriately supported decision-making process (assuming that this is what the pregnant woman wants). We conclude that, on balance, consent procedures for NIPD should mirror those for invasive testing, albeit without the need to emphasise procedure-related risk. (shrink)

AbstractŁukasiewicz introduced a new methodological approach to the history of logic. It consists of the use of modern formal logic in the research of the history of logic. Although he was not the first to use formal logic in his historical research, Łukasiewicz was the first who used it consistently and formulated it as a requirement for a historian of logic. The aim of this paper is to present Łukasiewicz's contribution and the history of its formulation. In addition, the paper (...) will present its reception. There are two main themes in Łukasiewicz’s work on the history of logic. He discussed Stoic logic and Aristotle’s syllogistic. The second part of the paper focuses on current reception of Łukasiewicz’s contribution and on the question of whether there is a difference between knowledge about his contribution to Stoic logic and to Aristotle’s syllogistic, given that it has been hypothesised that Łukasiewicz’s contribution is currently more known among Aristotelian scholars than among those who focus on Stoic logic. Based on the papers that have appeared in the last five years at Web of Science and Scopus this hypothesis has not been confirmed. (shrink)

Complementary and alternative medicine is becoming increasingly popular in western countries, with estimates of CAM usage as high as 40%. This has prompted a change of attitude of the medical establishment: the initial dismissal of CAM is being replaced by a drive to integrate CAM into the mainstream. Two possible explanations for this integration thrust are considered. Firstly, integration could be motivated largely by cognitive interest in CAM. Secondly, integration could be mainly power-driven, aimed at controlling the alternative movement and (...) exploiting its capacity to make money. The second explanation seems more plausible, and is supported by data showing the paucity of research on CAM. The medical establishment does not sufficiently appreciate the challenge CAM poses, and does not consider its scientific appraisal to be a high priority. Instead, the allopathic community seems preoccupied with the opportunistic desire to protect its authority and social status. Such a discourse can become dogmatic, reluctant to revise critically the ‘accepted’ body of knowledge. Popper's critical rationalism could help to undercut dogmatism and encourage a critical, open-minded orientation of medical science. (shrink)

Beginning with the assumption that the normative conception of Zen that Dōgen expounded and practiced constitutes at its heart a religio-philosophical practice, I focus on Dōgen’s zazen-only as its primary locus. Specifying the nature of zazen-only on and off the cushion, I seek to foreground the ways in which the transformation of apparent dualities into non-dual dualities is key to understanding Dōgen’s Zen as a religio-philosophical practice. Since this activity implicates more than experience, e.g., valuations, desires, goals, actions, reactions, etc., (...) i.e., the entire psycho-physical existence of the practitioner, it is itself philosophical in the demands it makes on practitioners in the “nitty gritty” of life. Further, the activity of transforming apparent dualities into non-dual dualities relies on two other important concepts that Dōgen utilizes, those of “weighing emptiness” and non-thinking. I, thus, focus on expounding the manner in which grappling with non-dual duality, weighing emptiness, and non-thinking should be seen as loci of Dōgen’s religio-philosophical activities. Lastly, I note that the extent to which someone can engage the philosophical dimensions will depend on the person, their motivations, and that of their teachers. Yet, the more deeply one can penetrate the various issues, ideas, and concepts at stake, the deeper one’s practice-realization.Yet, following Hee-Jin Kim’s treatment of it, weighing emptiness is vital to the dynamicity of practice-realization in the world. This is because weighing emptiness is a way to describe the transformation and engagement with a non-dual duality in the world. While not denying the idea of “equality in emptiness,” it insists that differences must be taken into consideration in realizing the fairness, reasonableness, and justness of the practitioner acting in the world. (shrink)

Los viajes y desplazamientos a Italia se desarrollan en cuanto al entorno eslovaco se refiere desde el siglo XIX. Este trabajo se centra en la investigación del viaje, que en sus diarios describe el sacerdote y escritor católico, Štefan Nemecskay, representante de la segunda generación de los seguidores de Bernolák y que han sido publicados originalmente en varias revistas. Aunque el punto de partida del análisis es la categorización de los aspectos de la representación literaria de Italia esbozada por M. (...) Beller (ayuda no sólo a resumir los conocimientos previos sobre el país o la forma del relato de viaje, por ejemplo, el grado de predominio de los hechos factuales sobre la representación subjetiva de las experiencias individuales), el objetivo del trabajo es sobre todo reflejar la estrategia personal del autor basada en subrayar las dimensiones espirituales de la vida y reavivar la relación del hombre con Dios. (shrink)

At the beginning of modern logic, propositions were defined as unchangeable entities placed in a certain idealistic realm. These unchangeable propositions contain in themselves so-called indexical, i.e. the place, time and other circumstances of the utterance. This concept of the proposition, which is entitled eternalism, was and is still prevalent among analytic philosophers. Often even the term ‘proposition’ is identified with an idealistic entity located outside the real world. In my paper, I would like to focus on the concept of (...) propositions of two logicians who deviated from the standard understanding of propositions, Arthur N. Prior and Pavel Tichý. They were both proponents of temporalism, i.e. the view that propositions could change their truth-value over time. The paper will discuss the reasons why they were proponents of temporalism and compare their views. It claims that in Prior’s case, his metaphysical views were the main reasons he was a proponent of temporalism. In contrast, when Tichý presented his arguments for temporalism, he focused primarily on natural language. (shrink)

The present study analyses education policy in Slovakia and determines the role of the church in education governance and the church–state relationship in education policy. The church–state relationship is also evident in the specific constellations of the national curriculum. The study highlights the de-secularisation trend in education policy and curricula and identifies the links between religious and nationalist education content, which are largely a relic of the historical era of Slovak statehood building. It also analyses Ethical Education, which is a (...) specific school subject in Slovakia that has been shaped by a particular church–state ‘ideological governing form’. (shrink)

The article discusses possible ways of overcoming the environmental crisis. It is based on Šmajs’ evolutionary ontological understanding of the environmental crisis of nature, which distinguishes between natural and cultural evolution and demonstrates the opposing relationships between them. It critically develops one of Šmajs’ proposals for initiating a biophilic transformation of culture by dealing with some of the consequences of the economic crisis (specifically unemployment).

This article examines the key conditions for the development of business ethics in the Slovak Republic, drawing on insights from the Global Survey of Business Ethics 2022–2024. By analyzing the survey's findings, we highlight the critical factors shaping the ethical landscape of Slovak businesses, including corporate governance, regulatory frameworks, and cultural influences. The study reveals a growing awareness of the importance of ethical practices among Slovak companies, with an emphasis on compliance, transparency, and corporate social responsibility. However, challenges persist, such (...) as inconsistent enforcement of regulations and the need for further education on ethical standards. We discuss the role of key stakeholders, including government, business leaders, and educational institutions, in fostering a culture of ethics within the country. Our findings offer valuable insights into the evolving nature of business ethics in Slovakia and suggest strategies for strengthening ethical practices in the business environment. (shrink)

[Reason and common sense; the Humean perspective].

Abstract This paper aims to analyse Karl Popper's conception of ?three worlds?, and especially the problem of world 3?the world of objective knowledge. Firstly, I try to explain Popper's turn to ontological questions which I link to his antipsychologism and to issues raised by the development of logic after World War II. I then consider Popper's concept of the autonomy of world 3 and his attempt to introduce world 3 as a world of knowledge without a knowing subject. I conclude (...) that Popper did not succeed in unifying his central idea of autonomy of knowledge with the requirement of the creative role of the critical subject carrying out the evolution of knowledge. I see the core of this contradiction especially in his co?existing ideas of the timeless existence of world 3 and the elimination of the subject from it. The attempt to desubjectivize the realm of objective knowledge leads to a philosophically unbalanced standpoint which presupposes a creative subject and at the same time neglects it. Finally, I question Popper's account of the growth of world 3. Popper considers only cognitive motivations, and excludes a broad range of motivating factors which originate in the problems which we face in our lives, and affect our cognitive interests in world 3. (shrink)

In recent times there has been a shift in the interpretation of Aristotle’s logic. Many researchers have pointed out that the concept of existential import appears in Aristotle’s logic and philosophy, and that Aristotle worked with the concept of empty terms although his concept differs from that which is used in modern logic. Additionally, his search for the “culprits” of old and incorrect interpretation has been tied to the development of modern interpretation. Apart from the traditional concept of the logical (...) square and syllogistics, where the assumption of non-emptiness of terms was widely used, J. L. Łukasiewicz is also labeled as an offender. This article tries to show that Łukasiewicz was aware that Aristotle was also dealing with empty terms. His restriction of syllogistics to only non-empty terms therefore differs significantly from the approach of traditional logicians. (shrink)

A unique feature of Hume’s epistemology is his concern for the philosopher’s state of mind in the process of doing philosophy. Philosophizing should bring agreeable feelings and avoid such contemplations that lead to distress. This is my main argument for proposing the affinity of Hume’s philosophy with the Pyrrhonian tradition. At the same time, however, Hume suspects that this goal is unattainable because a deep philosophical reflection necessarily leads to skeptical conclusions that give rise to depression. So how should a (...) philosopher bear this burden and “feel good” at the same time? For Hume, the conception of true philosophy remains contradictory, oscillating between an escape from philosophy to common life and the natural need to pursue profound reasoning. Hume later tries to remove these contradictions by proclaiming it necessary to blunt the edges of radical Pyrrhonism and move to the position of Academic skepticism. I have doubts about the success of his strategy. His proclaimed turn to academicism has no support in the ancient doctrines and, furthermore, Hume does not develop the theme of probable knowledge, which inspired the modern skeptics in their effort to provide rational foundations for the newly emerging sciences. (shrink)

The paper analyses empirical research results comparing the impact of the medium (traditional, paper-based vs. screen-based) on the reading process and text comprehension. It focuses on two analytical approaches—the first looks at the construction of cognitive maps of texts and the other the material aspects of the medium – which enable readers to orientate themselves and to explore and interpret the text more comprehensively. The paper discusses differences in how readers approach textual meaning according to experience of using digital technologies, (...) the text, and reader experience and abilities. It concludes by arguing that strengthening these individual experiences and abilities is key to effective inference of textual meaning. (shrink)

I shall situate Hume's scepticism within a broader philosophical and historical context. Firstly, I shall consider the place of Hume's thought within the early modern break with the almost millennium long metaphysical tradition, a break initiated by Descartes. The framework of being structured by a universal order was replaced by the individual human mind that broke free from any higher authority and became an autonomous cognitive agent. Subsequently, the ontological self-evidence of the world or the possibility of adequate knowledge came (...) under sceptical attack. Hume firmly belongs to this discourse and can be seen as themost consistent exponent of this early modern sceptical line. In this light, the ‘New Hume’ claim that Hume was an ontological realist will be shown to be misplaced in principle. Secondly, the strong influence of Pyrrhonism on Hume's philosophy will be considered, together with his concept of mitigated scepticism. The Pyrrhonian legacy is especially noticeable in Hume's acceptance of the weakness of reason and in his emphasis on the instructive role of philosophy – instead of attempting to make it the foundation of science it becomes a guide to a balanced, happy life. In this respect, Hume standsoutside the early modern mainstreamin philosophy. (shrink)

Cancer cells accumulate widespread local and global chromatin changes and the source of this instability remains a key question. Here we hypothesize that chromatin alterations including unscheduled silencing can arise as a consequence of perturbed histone dynamics in response to replication stress. Chromatin organization is transiently disrupted during DNA replication and maintenance of epigenetic information thus relies on faithful restoration of chromatin on the new daughter strands. Acute replication stress challenges proper chromatin restoration by deregulating histone H3 lysine 9 mono‐methylation (...) on new histones and impairing parental histone recycling. This could facilitate stochastic epigenetic silencing by laying down repressive histone marks at sites of fork stalling. Deregulation of replication in response to oncogenes and other tumor‐promoting insults is recognized as a significant source of genome instability in cancer. We propose that replication stress not only presents a threat to genome stability, but also jeopardizes chromatin integrity and increases epigenetic plasticity during tumorigenesis. (shrink)

Štúdia analyzuje povahu etických otázok inherentných sociálnej práci a na vybraných problémoch ukazuje, ako a pre?o tieto etické otázky vznikajú. Zameriava sa na tri ústredné otázky, pod ktoré možno subsumova? vä?šinu etických problémov. Po prvé, pre?o dodržiava? morálne normy, aké dôvody máme preto, aby sme prijali morálku za rámec svojho konania? Po druhé, akým spôsobom majú by? distribuované zdroje a formy dobra? Po tretie, ktoré ?iny sú považované za hodnotné, dobré a žiaduce? Autorka obhajuje ideu, že na rozdiel od iných (...) profesií, definovanie cie?a, predmetu sociálnej práce a jej samotný výkon, tým, že pracuje s vylú?enými diskriminovanými a marginalizovanými skupinami je úzko previazaný na morálne a politické hodnoty. (shrink)