Isthmin‐1 (Ism1) was first described to be syn‐expressed with Fgf8 in Xenopus. However, its biological role has not been elucidated until recent years. Despite of accumulated evidence that Ism1 participates in angiogenesis, tumor invasion, macrophage apoptosis, and glucose metabolism, the cognate receptors for Ism1 remain largely unknown.Ism1deficiency in mice results in renal agenesis (RA) with a transient loss ofGdnftranscription and impaired mesenchyme condensation at E11.5. Ism1 binds to and activates Integrin α8β1 to positively regulate Gdnf/Ret signaling, thus promoting mesenchyme condensation (...) and ureteric epithelium branching morphogenesis. Here, we propose the hypothesis underlying the mechanism by which Ism1 regulates branching morphogenesis during early kidney development. (shrink)

This study examined the extent to which the impact of green transformational leadership on employee green behavior through follower perceptions of value congruence. Path analyzing on data from 193 subordinate-leader dyads showed that followers’ value congruence with their leader mediated the effects of green transformational leadership on employee green behavior. Results also supported that green identity moderated the indirect effect of green transformational leadership on employee green behavior through value congruence, such that the indirect effect was more positive when green (...) identity was high than when it was low. These findings provided valuable contribution to green transformational leadership, value congruence and employee green behavior by exploring the relationship between them. Practical implications and directions for future research are also discussed. (shrink)

Three hundred and seventy-six middle school students in Wenchuan County were assessed three and one-half years after the Wenchuan earthquake to examine the effects of rumination on posttraumatic stress disorder (PTSD) and posttraumatic growth (PTG). The results revealed that recent intrusive ruminations partly mediated the relationship between intrusive rumination soon after the earthquake with PTSD but not with PTG. Recent deliberate rumination partly mediated the relationship between intrusive rumination soon after the earthquake and PTG but not PTSD. Moreover, recent deliberate (...) rumination also partly mediated the relationship between recent intrusive rumination with PTG but not with PTSD. Overall, intrusive rumination soon after the earthquake had an effect on PTSD but not on PTG through recent intrusive rumination and affected PTG but not PTSD through deliberate recent rumination. Furthermore, intrusive rumination soon after the earthquake affected PTG but not PTSD by recent deliberate rumination following recent intrusive rumination. More importantly, the present study also found that PTSD exhibited no relation to PTG. These results suggest that PTSD and PTG are influenced by different mechanisms, which further indicates that PTSD and PTG represent two separate dimensions of experience after adversity. (shrink)

It has limitations to understand “fidelity” of the Analects of Confucius in the thinking pattern of subject-object. The interpretation patterns of self-other and private-public ethics can’t also completely explain the philosophical meaning of “fidelity” in the Analects of Confucius. “Fidelity”, in Confucian theory and practice, has important place, therefore, the paper will try to explore the philosophical meaning of “fidelity” of Confucius from the following suppositions in order to find a new way of philosophical explanation. The suppositions are as the (...) following: First of all, “fidelity” can’t be understood, in Chinese, as a verb which means “faithful to sb”. It is a noun or a gerund. Basing on the distinction of “material world” and “meaning world”, the paper holds that the connotation of “fidelity” has its inner regulation and its meaning is, first of all, regulated not by the material world but by the other contextual logic categories, in this way, it has the characteristic of independence and transcendence. The core meaning of “fidelity” is “center”, the paper calls it as “the centric wisdom” from the epistemological perspective. Wesuppose that Confucius has presupposed that every life has enough wisdom to know what the affirmative value is. For Confucius, his philosophical thinking on “fidelity” has both traditional heritage and personal innovation. We should pay attention to the latter. Basing on the understanding that takes “fidelity ”as “the centric wisdom”, the paper holds that one of the meanings of “fidelity”, as an ethical concept, in the Analects of Confucius, is personal ethics which includes thereorganization of individual values. One part of the individual value is to recognize and practice the value which is independent of social value. Another part of the value is to practice and exhibit the wisdom of “fidelity” in personal speech and behavior including the spiritual activities. The “fidelity” of the Analects of Confucius, as an ethical concept, has another meaning, i.e. the inter-personal relationship which shows the affirmative value under the guidance of wisdom. The inter-personal relationship under the guidance of wisdom can exhibit the affirmative value and can be called as the “ethical” relation. The main requirements are as the following: we have to bring the reflective factor of “wisdom” into inter-personal relation and, under the guidance of wisdom, try to take our social responsibilities required by the social role, or to abide by the public or the professional ethics. We have to maintain positive value direction in the verticalinter-personal relation which means supervision so as to realize the political affirmation. In the horizontal interpersonal relationship, basing on the individual wisdom, we have to keep the keen feeling of morality so as to realize our affirmative values. The understanding of these meanings concerning the word of “fidelity” is naturally resulted from our concern for the inner logic relation in the Analects of Confucius and for the form of idea-expressing of Confucius. (shrink)

Objective: The objective of this study was to evaluate the psychometric properties of the Chinese version of the decision regret scale. Methods: The data of 704 patients who completed the DRSc were used for the analyses. We evaluated the construct, convergent/discriminant, and known-group validity; internal consistency and test–retest reliability; and the item invariance of the DRSc. A receiver operating characteristic curve was employed to confirm the optimal cutoff point of the scale. Results: A confirmatory factor analysis indicated that a one-factor (...) model fits the data. The internal consistency and test–retest reliability [intraclass correlation coefficient = 0.71] of the DRSc were acceptable. The DRSc demonstrated unidimensionality and invariance for use across the sexes. It was confirmed that an optimal cutoff point of 25 could discriminate between patients with high and low decisional regret during clinical practice. Conclusion: The DRSc is a parsimonious instrument that can be used to measure the uncertainty inherent in medical decisions. It can be employed to provide knowledge, offer support, and elicit patient preferences in an attempt to promote shared decision-making. (shrink)

Hybrid energy storage system has been widely studied as an important technology for electric vehicles. Since the hybrid energy storage system is a nonlinear and complex system, the modeling of the system and the high-precision nonlinear control strategy are technical difficulties for research. The establishment of a high-precision mathematical model of the hybrid energy storage system is the basis for the study of high-quality nonlinear control algorithms. Fortunately, the theory of fractional calculus can help build accurate mathematical models of hybrid (...) energy storage systems. In order to obtain the high-quality nonlinear control strategy of this complex system, this paper, respectively, carried out fractional-order modeling and analysis on the three basic equivalent working states of the hybrid energy storage system of electric vehicles. Among them, the fractional-order average state space model is carried out for the equivalent Buck and Boost mode. Also, the steady-state analysis of the equivalent Dual-Boost mode is carried out by combining the fractional-order calculus theory with the equivalent small parameter variable method. Finally, the effectiveness and precision of the fractional-order model are proved by simulation and experiment. (shrink)

This study investigated eye-movement patterns during emotion perception for children with hearing aids and hearing children. Seventy-eight participants aged from 3 to 7 were asked to watch videos with a facial expression followed by an oral statement, and these two cues were either consistent or inconsistent in emotional valence. Results showed that while normal-hearing children paid more attention to the upper part of the face, children with hearing aids paid more attention to the lower face after the oral statement was (...) presented. When there was an inconsistency between the visual and auditory cues, children with hearing aids were likely to increase attention to the upper face. The results revealed the underlying mechanism of deficits in emotion perception for hearing-impaired children. (shrink)

This article aims to explore contemplative practitioners’ direct lived experiences of enlightenment and develop a multi-item scale measuring these experiences. A mixed-method approach was adopted. The first study is a phenomenological study that interviewed 24 participants with enlightenment experiences and the second study is a scale-development study that recruited 1130 participants for scale validation. Two major clusters of the enlightenment experiences including sensory feelings and nondual realizations emerged from the phenomenological study and the four main themes of the realizations were (...) formed: intrapersonal insights, inspiration internalization, interpersonal compassion, and interconnectedness. After exploratory factor analysis and confirmatory factor analysis, a three-factor structure of the Spiritual Enlightenment Experience Scale, including nonduality, sensory clarity, and sensory disappearance were revealed. The findings of the research depicted a fuller picture of spiritual enlightenment experiences which may contribute to the current knowledge of religiosity and spirituality, as well as transpersonal psychology. The results suggest that the core components of spiritual enlightenment experiences include sensory clarity and disappearance experiences and realizations of nonduality. (shrink)

ObjectiveThe large-scale epidemic of Coronavirus Disease 2019 has triggered unprecedented physical and psychological stress on health professionals. This study aimed to investigate the prevalence and risk factors of burnout syndrome, and the relationship between burnout and depressive symptoms among frontline medical staff during the COVID-19 epidemic in China.MethodsA total of 606 frontline medical staff were recruited from 133 cities in China using a cross-sectional survey. The Maslach Burnout Inventory was used to assess the level of burnout. Depressive symptoms were assessed (...) by the Patient Health Questionnaire Depression.ResultsDuring the COVID-19 pandemic, 36.5% of the medical staff experienced burnout. Personal and work-related factors were independently associated with burnout, including age, family income, having physical diseases, daily working hours, and profession of nurse. The correlation coefficients between the scores of each burnout subscale and the scores of depressive symptoms were 0.57 for emotional exhaustion, 0.37 for cynicism, and −0.41 for professional efficacy.ConclusionsOur findings suggest that the prevalence rate of burnout is extremely high among medical staff during the COVID-19 pandemic, which is associated with other psychological disorders, such as depression. Psychological intervention for medical staff is urgently needed. Young and less experienced medical staff, especially nurses, should receive more attention when providing psychological assistance. (shrink)

BackgroundPsychological resilience may reduce the impact of psychological distress to some extent. We aimed to investigate the mental health status of the public during the outbreak of coronavirus disease 2019 and explore the level and related factors of anxiety and depression.MethodsFrom February 8 to March 9, 2020, 3,180 public completed the Zung’s Self-Rating Anxiety Scale for anxiety, Zung’s Self-Rating Depression Scale for depression, the Connor–Davidson resilience scale for psychological resilience, and the Simplified Coping Style Questionnaire for the attitudes and coping (...) styles.ResultsThe number of people with depressive symptoms was 1,303. The number of people with anxiety symptoms was 1,184. The depressed group and anxiety group had less education, more unmarried and younger age, as well as had significant different in SDS total score, SAS total score, CD-RISC total score, and SCSQ score. The binary logistic regression showed that female, strength, and the subscales of active coping style in SCSQ remained protective factors and passive coping style and higher SAS score were risk factors for depression. Optimism in CD-RISC was a protective factor, and passive coping styles and higher SDS score were risk factors for anxiety.LimitationsThis study adopted a cross-sectional design and used self-report questionnaires.ConclusionThe mental health of the public, especially females, the younger and less educational populations, and unmarried individuals, should be given more attention. Individuals with high level of mental resilience and active coping styles would have lower levels of anxiety and depression during the outbreak of COVID-19. (shrink)

Consumer indirect misbehavior in access-based consumption is a significant challenge for enterprises. The literature is in short of a deep understanding of the antecedent conditions of consumer indirect misbehavior in this context and limited by inconsistent findings, calling for developing a holistic and integrative theoretical framework. This study integrates three commonly used theoretical perspectives in the consumer misbehavior literature to present holistic archetypes of consumer indirect misbehavior formation. In accordance with this theoretical objective, we adopted an emerging approach for configurational (...) analysis, i.e., fuzzy-set qualitative comparative analysis, to analyze the complex combinations of six influencing factors. We collected data using a scenario-based field survey of 264 experienced consumers of a popular bike-sharing service in China. The scenarios were developed based on relevant literature and a Delphi study. The fsQCA results reveal multiple configurations for high and low levels of consumer misbehavior intention. Specifically, perceived benefits and moral definition play important roles, while the effect of sanctions is highly dependent on other factors. These results lead us to derive three theoretical propositions for antecedent conditions leading to consumers’ indirect misbehavior intentions in access-based consumption. This study enriches our understanding of the causes of misbehavior and provides novel insights for management practitioners to take appropriate countermeasures. (shrink)

Background: Previous systematic review indicated the prevalence of prenatal anxiety as 14–54%. Pregnant women are a high-risk population for COVID-19. However, the prevalence of anxiety symptoms and related factors is unknown in Chinese pregnant women during COVID-19 outbreak.Objective: To investigate the prevalence of anxiety symptoms and the related factors in Chinese pregnant women who were attending crisis intervention during the COVID-19 pandemic.Methods: The data of this cross-sectional study were collected in about 2 months. Data analysis was performed from April to (...) May 2020. Participants completed a set of questionnaires via the Wechat Mini-program before starting the online self-help crisis intervention for COVID-19 epidemic. A total of 2,120 Chinese pregnant women who were attending a self-help crisis intervention participated in this study. A survey was developed to address possible stress-related factors in pregnant women during the COVID-19 outbreak, including demographic, socioeconomic, and pregnancy-related factors, as well as COVID-19 related factors. Generalized Anxiety Disorder-7 scale and the 10-item perceived stress scale were, respectively, employed to measure anxiety and stress-related factors.Results: A total of 21.7% of pregnant women reported at least mild anxiety, and only 82 women reported moderate to severe anxiety. Factors associated with at least mild anxiety included living in Hubei province, nobody providing everyday life support, pelvic pain or vaginal bleeding, and higher perceived stress. Having relatives or neighbors with a diagnosis of COVID-19 was not associated with anxiety.Conclusions and Relevance: Our findings indicate that evaluation and intervention for maternal and infant health are necessary in pregnant women with anxiety during COVID-19 epidemic, especially those with higher perceived stress, less everyday life support, or vaginal bleeding. Interactions among these related medical, social and psychological factors need to be investigated in future studies. (shrink)

The Fear of COVID-19 Scale (FCV-19S) is a new one-dimensional scale used to measure fear of an individual about the COVID-19. Given the seriousness of the COVID-19 situation in China when our study was taking place, our aim was to translate and examine the applicability of the FCV-19S in Chinese students. The sample used for validation comprised 2,445 Chinese students. The psychometrical characteristics of the Chinese FCV-19S (FCV-19S-C) were tested using Rasch analysis. Principal component analysis (PCA) proved the unidimensional structure (...) of the model. Both infit and outfit mean square (MNSQ) values (0.69–1.31) and point-measure correlations (0.82–0.86) indicated a good model fit. Person-item separation and reliability values indicated good reliability of the scale. The person-item map revealed an acceptable level of match between the persons and the items. Differential item functioning of the FCV-19S-C showed no differences with respect to age or gender. FCV-19S-C scores were significantly associated with anxiety, stress, depression, ego-resilience, and general health. The FCV-19S-C was proven to be effective in measuring fear of Chinese students about the COVID-19. (shrink)

Technology licensing as a vital part of business behavior in many industries has drawn a fair amount of attention in industrial organization literature. Most existing literature on licensing decisions assumes that all firms engage in Cournot or Bertrand competition, while the type of mixed competition may affect the choice of the licensor. In this context, what decision will the licensor make faced with different mixed competitions? This paper studies the optimal technology licensing contract of a licensor firm engaging in different (...) mixed competitions with a potential licensee in a differentiated duopoly market considering one upstream firm that provides key inputs. We find that if either the royalty or fixed-fee licensing is applied, the licensor favors royalty licensing under Bertrand-Cournot competition when the degree of substitution is small and prefers the fixed-fee licensing no matter under what kind of mixed competition as the degree of substitution increases. In the case of fixed-fee licensing, the result shows that the profits of licensors are the same under different types of mixed competition. Besides, fixed-fee licensing is not always the optimal choice for consumers, and they would prefer royalty licensing when the degree of substitution is very small. (shrink)

The youngest generation of students prefers a more active learning style. Sandwich teaching may suit their learning style by alternating between active individual learning and passive collective learning. Sandwich teaching has been rarely applied to the Community Nursing Course for nursing students, and its teaching effects on this course remain unclear. This study applied Sandwich teaching to the Community Nursing Course for Chinese nursing undergraduates and investigated its effects on students' critical thinking, self-learning ability, course experience, and academic performance. This (...) is a quasi-experimental study with 72 Chinese nursing undergraduates. Students receiving traditional teaching were enrolled in the control group, and those who received Sandwich teaching were recruited into the experimental group. Both groups received the 12-week, 90-min Community Nursing Course. Our main outcome variable, including students' critical thinking, self-learning ability, and course experience, was assessed by specific questionnaire. The paired t-tests were applied to compare the differences of the same group in the pre-test and the post-test, and the independent-sample t-tests were used to compare the differences between the two groups. We observed that nursing students' critical thinking ability and self-learning ability were significantly improved after receiving Sandwich teaching. Students' course experience of Sandwich teaching was significantly better than that of traditional teaching. The final exam score in the experimental group was not significantly higher than that in the control group. These results suggest that Sandwich teaching in Community Nursing Course improved Chinese nursing undergraduates' critical thinking, self-learning ability, and course experience, but failed in improving academic performance. (shrink)

This paper addresses the adaptive asymptotic tracking control problem for nonlinear systems whose virtual control gains are unknown nonlinear functions of system states. Only in the first step, the Nussbaum gain technique is utilized to handle the uncertain virtual control gain. In the remaining steps, virtual control gains are dealt with by constructing novel control laws without the approximation of the uncertain nonlinear functions and external disturbances by neural networks or fuzzy logic. New adaptive laws are defined to compensate for (...) unknown virtual control gains, uncertain parameters, and external disturbances. Finally, an adaptive tracking controller is designed and applied to the control of a 3-order robot system, which guarantees the boundedness of all the signals in the closed-loop system and asymptotic stability of the tracking error. (shrink)

Accurate identification of legal provisions is crucial for adjudicating criminal cases, but the complexity and volume of legal texts pose significant challenges for legal professionals. This paper addresses these challenges by introducing a novel legal provision selection framework that transforms the task from a simple classification problem into a sophisticated system combining semantic matching with causal relationship learning. Leveraging large language models, our approach enhances the understanding and interpretation of legal language, by extracting nuanced features from legal texts for deeper (...) contextual comprehension. Additionally, integrating causal learning aligns with the inherent causality in legal reasoning, improving model interpretability and mitigating data bias. Our method demonstrates superior accuracy and robustness through extensive experiments on the CAIL2018 dataset and its subsets. This research significantly advances legal AI applications, promoting efficiency and fairness in the criminal justice system by providing precise and reliable legal provision selection. (shrink)

Along with urban development globally, the NIMBY crisis has been a complex social problem, which requires urgent remedial action. The inevitable management of Municipal Solid Waste has been one of the toughest risk management tasks in the worldwide modernization process. At present, certain fuzzy and unstructured results and methods have been formed for MSW-NIMBY crisis response, mainly focusing on the sociology and politics which scatter in complex and sensitive reports and news. Aiming at enhancing the effectiveness of data mining from (...) specific sparse text of MSW-NIMBY crisis, an improved knowledge extraction method is developed. Through rule-based text mining and complex network analysis, the Entity Relationship network of MSW-NIMBY crisis is reconstructed. Meanwhile, a novel transitivity for relationship between entities in semantic analysis is proposed to improve the feasibility and accuracy of information extraction. Characteristics and regularity of MSW-NIMBY crisis evolution and experience of crisis governance could be identified effectively. Results show that knowledge integration and ER transitivity can enhance knowledge recognition and major other factors, which could help formulate the governance strategies of NIMBY crisis from academic texts. (shrink)

Rural electrification is now and will remain an essential element for rural development in China and other developing countries. With more than half of the world’s population living in rural communities, lessons for rural renewable energy applications and assessment from China can be very helpful in defining a global sustainable development strategy. This paper describes energy needs in rural China, examines the resource availability of three provinces (Inner Mongolia, Qinghai and Xinjiang in Western China), and evaluates rural energy options and (...) the economics of stand-alone off-grid renewable energy technologies for rural application in this region. An eight-year collaborative effort between several of China’s leading energy and environmental research institutes and the Center for Energy and Environmental Policy demonstrates the existence of a viable renewable energy-based strategy to address rural electricity needs in a socially and environmentally sustainable manner. (shrink)

Ecopsychology holds that a full-fledged self should be in harmony with nature, but when the human’s social self, consumptive false self, and paranoid cultural narcissism prevail, the ecological self goes from dominant existence to recessive existence. Because of this predicament with regard to the ecological self, one should make full use of wildness spirit to reshape the ecological self. Due to the abstract nature of the wilderness spirit and in an attempt to present the wilderness spirit in a more concrete (...) and vivid way, the wilderness spirit needs to be set apart from wilderness literature so as to analyze the role that the wilderness spirit plays in rebuilding the ecological self. (shrink)

With increasing market competition and rapid development of service economy, more and more enterprises are shifting from providing products or services to providing product-service systems that integrate products and services, in order to improve competitiveness and profitability. Meanwhile, consumers have strategic delayed purchasing behavior when purchasing the PSS and high requirements for service quality. This paper investigates the two-period pricing and service quality decisions of product-service supply chain considering consumers’ strategic behavior under decentralized and centralized scenarios. The equilibrium results are (...) compared in two scenarios. In order to eliminate performance loss under the decentralized scenario, we design two-period dynamic contracts to coordinate the PSSC. Furthermore, numerical simulation is provided to verify the feasibility of the contracts. The following conclusions can be drawn: the higher the service input-efficiency, the more beneficial for alleviating consumers’ strategic purchase behavior under two scenarios, but this mitigation effect is more obvious under the centralized scenario. Compared with the centralized scenario, the service quality is lower, the two-period PSS sales prices are higher, and the two-period profit is lower under the decentralized scenario. The proportion of service valuation will promote the widening of the service quality gap under two scenarios, but in some cases, the service input-efficiency will weaken the promotion effect of the proportion of service valuation. The design of the two-period combined contracts depends on the proportion of service valuation. When the proportion of service valuation is high, the “two-period revenue sharing + service-cost sharing” combined dynamic contract can achieve PSSC perfect coordination. However, when the proportion of service valuation is low, it is necessary to design complexity combined dynamic contract which can achieve PSSC perfect coordination. (shrink)

BackgroundUser selection is an important guarantee for the sustainable development of mobile medical businesses. Under the background of increasingly fierce competition, the decision-making behavior of mobile medical businesses will directly affect the choice of the behavior of users.MethodsThe study constructs the decision-making behavior model of mobile medical business based on the user choice and adds the role of people in government. It uses the game method to explore the relationship between the government, mobile medical business, and users. Finally, it makes (...) an example analysis. Empirical research is conducted to demonstrate the influence of different parameter changes on the results.ResultsThe results show that in the absence of government intervention, users’ choice of filtering information will create a bad environment for mobile medical businesses, and further will be reduced, and the expected utility of businesses will not be affected causing a reduction in expected utility of companies. Similarly, government regulations can effectively improve the mobile medical environment and enhance the expected utility of mobile medical companies.ConclusionThe government needs to formulate relevant laws and regulations to ensure the orderly operation of the mobile medical market and strengthen government supervision. It is necessary to conduct publicity and education to protect the fundamental interests of users and businesses. (shrink)

The performance of the grinding wheel demonstrably affects the machining efficiency and the quality of the workpiece. Therefore, it is essential to evaluate the wear of the wheel and then operate the dressing or replacement in time. The wear procession of the wheel was monitored and evaluated systematically in this paper. A surface grinding experiment was performed by using an alumina wheel to grind the workpiece made of Cr12. The grinding force and the grinding temperature were monitored and measured while (...) the wheel grinds the workpiece. The surface topography of the wheel was also being observed. The distribution of the gray value of pixels in the image of the wheel surface was analyzed by the method of the histogram. Processing of the binary image of the wheel was performed after determining the gray threshold of the gray value. Then, the blockading and the wearing area on the grinding wheel were calculated. Moreover, the relation of the projection area of a single abrasive derived from theory and derived by image recognition was studied. The results of the grinding experiment show that wheel performance degradation occurs when the material removal volume reaches 210 mm3/mm. At this time, the ratio of blockage area on the grinding wheel reaches 13.4%. The percentage of the wearing area is 9.5%. The method of image recognition combined with grinding temperature is workable to realize monitoring and evaluating the wear of wheels on site without unloading them. (shrink)

Based on the data of four periods of CLHLS, the latent variable growth model was applied to 2344 older adults who completed four follow-up surveys, to study the trajectory of leisure activities and cognitive ability and explore the relationship between leisure activities and cognitive ability of older adults. The results showed that: leisure activities and cognitive ability of older adults showed a non-linear downward trend; leisure activities significantly and positively predicted the cognitive ability of older adults at every time point; (...) the initial level of leisure activity positively predicted the initial level of cognitive ability but negatively predicted the rate of cognitive decline; In addition, cognitive activities had a greater effect on cognitive ability than non-exercise physical activities; the rate of decline of leisure activities also significantly and positively predicted the rate of decline of cognitive ability; cross-lagged regression analysis further suggested the overall positive predictive effect of leisure activity on cognitive ability; overall, education level had a significant contribution to cognitive ability, and the higher the education level, the slower the decline of cognitive ability; and smoking could promote cognitive ability in older adults and no significant effect was found between alcohol drinking and cognitive ability. Accordingly, the government should encourage older adults to do more leisure activities, especially the cognitive activity, to effectively prevent cognitive decline. (shrink)

Background: Individuals’ information processing includes automatic and effortful processes and the latter require sustained concentration or attention and larger amounts of cognitive “capacity.” Event-related potentials reflect all neural activities that are related to a certain stimulus. Investigating ERP characteristics of effortful cognitive processing in people with schizophrenia would be helpful in further understanding the neural mechanism of schizophrenia.Methods: Both schizophrenia patients and health controls completed ERP measurements during the performance of the basic facial emotion identification test and the face-vignette task. (...) Data of ERP components, BFEIT and FVT performances were analyzed.Results: Schizophrenia patients’ accuracies of face emotion detection in the BFEIT and vignette emotion detection in the FVT were both significantly worse than the performance of the HC group. Repeated-measures ANOVAs performed on mean amplitudes and latencies revealed that the interaction effect for group × experiment × site was significant for N250 amplitude. In FVT experiment, N250 amplitudes at prefrontal and frontal sites in schizophrenia group were larger than those of HC group; the maximum N250 amplitude was present at the prefrontal site in both the groups. For N250 latency, the interaction effect for group × experiment was significant; N250 latencies in the schizophrenia group were longer than those of the HC group.Conclusion: Schizophrenia patients present effortful cognitive processing dysfunctions which reflect in abnormal ERP components, especially N250 at prefrontal cortex and frontal cortex sites. These findings have important implications for further clarifying the neural mechanism of effortful cognitive processing deficits in schizophrenia. (shrink)