Antigen presentation to CD8+ T cells by MHC class I molecules is essential for host defense against viral infections. Various mechanisms have evolved in multiple viruses to escape immune surveillance and defense to support viral proliferation in host cells. Through in vitro SARS‐CoV‐2 infection studies and analysis of COVID‐19 patient samples, we found that SARS‐CoV‐2 suppresses the induction of the MHC class I pathway by inhibiting the expression and function of NLRC5, a major transcriptional regulator of MHC class I genes. (...) In this review, we discuss the molecular mechanisms for suppression of the MHC class I pathway and clinical implications for COVID‐19. (shrink)

Employing conversation analysis, this article investigates instructions in lessons for guitar and Japanese calligraphy. In receiving an instruction, the students in the guitar lessons are expected to immediately follow the instruction. In contrast to the guitar lessons, the students in the calligraphy lessons are not institutionally expected to immediately follow the teacher’s instructions but to receive them. However, the students often gesticulate what they learned from and could make sense of the prior instruction upon completion of an instruction activity. I (...) call this phenomenon embodied solitary confirmation. By demonstrating the interactional procedure for this practice, this article respecifies reflection as an interactional phenomenon and elucidates an organization of multiactivity. (shrink)

This paper aims to analyze R. G. Collingwood’s maiden work in philosophy, Religion and Philosophy, in the light of the realism/idealism dispute in early twentieth-century British philosophy. Due to scholars’ narrow scopes of interests, this book has suffered divided and unsettled understandings in literature that find only either realist or idealist character in it. By contrast, I comprehensively examine various aspects of the work on which both readings rest in turn—his conception of history and metaphysics. Consequently, I find out that (...) Collingwood implicitly elaborates a series of negative doctrines attempting to overcome dualismspervading at both poles of the dispute, namely abstract/concrete, subject/object, and theory/action. Since this framework is to be more explicitly present in his subsequent philosophizing, I demonstrate that Religion and Philosophy was, against its underestimated status in literature, not mere juvenilia, but a substantialstarting-point for Collingwood’s philosophy constructively grounded in the contemporary debate. (shrink)

LK is much more difficult than NK, and to make matters worse, Gentzen's intention is still unclear when it comes to that system (LK). -/- This book, Vol.1 of the series titled What is LK?, tackles this issue, focusing on the sequent, the most enigmatic notion we find in LK. The dependence-relation we find in NK shall play a crucial role in that investigation. -/- The style is typically textbook-like, so readers can learn the system of LK, using this series (...) as a guidance, too. (shrink)

The vestibulo-ocular reflex plays an important role in controlling the gaze at a visual target. Although patients with vestibular hypofunction aim to improve their VOR function, some retain dysfunction for a long time. Previous studies have explored the effects of direct current stimulation on vestibular function; however, the effects of random noise stimulation on eye–head coordination have not previously been tested. Therefore, we aimed to clarify the effects of high frequency noisy vestibular stimulation on eye–head coordination related to VOR function. (...) Thirteen healthy young adult participants with no serious disease took part in our study. The current amplitude and density used were 0.4 mA and 0.2 mA/cm2, respectively, with a random noise frequency of 100–640 Hz. The electrodes were located on both mastoid processes. The stimulus duration and fade in/out duration were 600 and 10 s, respectively. Subjects oscillated their head horizontally, gazing at the fixation point, at 1 Hz for 30 repetitions. The coordination of eye–head movements was measured by eye-tracking and a motion capture system. Peak-to-peak angles for eye and head movement and deviation of the visual line from the fixation target revealed no significant differences between HF-nVS and sham. The lag time between the eye and head movement with HF-nVS post-stimulation was significantly shorter than that of the sham. We found that HF-nVS can reduce the lag time between eye and head movement and improve coordination, contributing to a clear retinal image. This technique could be applied as a form of VOR training for patients with vestibular hypofunction. (shrink)

Categorial grammar is well-known for its elegant analysis of coordination enabled by the flexible notion of constituency it entertains. However, to date, no systematic study exists that examines whether this analysis has any obvious empirical advantage over alternative analyses of nonconstituent coordination available in phrase structure-based theories of syntax. This paper attempts precisely such a comparison. We compare the direct constituent coordination analysis of non-canonical coordinations in categorial grammar with an ellipsis-based analysis of the same phenomena in the recent HPSG (...) literature. We provide a set of empirical evidence, consisting of cases in which non-canonical coordinations interact with scopal operators of various sorts, which systematically falsifies the predictions of the latter, ‘linearization-based’ ellipsis approach to coordination. We propose an alternative analysis in a variant of categorial grammar called Hybrid Type-Logical Categorial Grammar. The proposed framework builds on both the Lambek-inspired variants of categorial grammar and a more recent line of work modelling word order via a lambda calculus for the prosodic component. The flexible syntax–semantics interface of this framework straightforwardly captures the interactions between non-canonical coordinations and scopal expressions, demonstrating the broader empirical payoff of the direct constituent coordination analysis of non-canonical coordinations pioneered by Steedman :523–568, 1985; Linguist Philos 13:207–263, 1990) and Dowty hitherto not explicitly recognized in the literature. (shrink)

The phenomenological vision, particularly, Husserl’s idea of critique as an infinite vocational theoria and Patočka’s as an enduring programme, view Platonic logic and Socratic act as the paradigms for a normative justification of the idea of universal science and philosophy. In light of that, the Thrasymachus-Socrates debate is interpreted as a case to testify the critical power of philosophy successfully exercised over sophistic tyrannical non-philosophy. This paper criticizes the phenomenological idealization of the Socratic victory as an ethico-teleologically anticipated success of (...) philosophy and rewrites the defeat of Thrasymachus as a political failure in warring with philosophy during which Thrasymachus questions the legitimacy of the act of philosophizing to decide its legitimacy and thereby exposes the politics played out in that act. (shrink)

Although written in Japanese, 実践的三段論法について（On Practical Syllogisms）pursues a logical form of the practical syllogism.

Although written in Japanese, this book becomes a landmark of my works so far: that on Zangwill (Kaneko, 2011), that on Utilitarianism (2013), and so on. The novelty shown in it is a formalization of traditional philosophy including Kant (its practical philosophy), Utilitarianism (Hume, Bentham, and Mill), and furthermore, Descartes. I try to locate these traditional thoughts within modern forms which I make in the name of "practical syllogism." This attempt would open up a new approach to ethical motivation.

In spite of the evident centrality of philosophical 'realism' in Collingwood's autobiographical account of his own intellectual development, his critique of 'realism' has hardly been investigated as a central theme in his philosophy. Collingwood's arguments against contemporary 'realism' and his stated move beyond 'idealism' have mostly been treated as a minor question subordinate to other questions. By contrast, I have tried in this thesis to reconstruct Collingwood's philosophy as a critical development of the realism/idealism dispute of his day, focusing on (...) his less known early published and unpublished philosophical writings. This has enabled me to clarify his unique definition of 'realism' in terms of a dualistic framework, and understand his philosophy as an attempt to overcome such dualisms in the realms of philosophy. This approach ultimately highlighted the aim of Collingwood's reform of philosophy as the better understanding of the human mind and action. By employing the 'historical' and 'internal' method of analysis, I firstly illustrated how the idea of 'dualism' became an issue in the realism/idealism dispute as it emerged in early twentieth-century British philosophy. This was followed by a biographical sketch in which I demonstrated that Collingwood's educational background was perfectly equipped to refute the 'realist' philosophy in the dispute. Historically contextualising thus, I chronologically restored the formation of his critique of 'realism' as his attempts to synthesise dualisms in logic, ontology, epistemology, and ethics during the period between Religion and Philosophy and An Essay on Philosophical Method. Finally, I argued that Collingwood's critique of 'realism' crystallised in his notion of duty, which embodied his characterisation of philosophy as both 'normative' and 'descriptive'. Throughout, I presented a systematic and sustained picture of Collingwood's early philosophy, identifying and unfolding the fertile implications of his critique of 'realism' for his principal concern with the human mind and action. (shrink)

Miyagawa (Games and Economics Behavior 41(2), 292–308 [2002]) provides a simple extensive game form that implements a large class of two-agent bargaining solutions in subgame-perfect equilibrium. This class includes all of the Nash, Kalai–Smorodinsky, and relative utilitarian solutions. This note extends Miyagawa’s result to multi-agent bargaining problems.

Real-world walking activity is important for poststroke patients because it leads to their participation in the community and physical activity. Walking activity may be related to adaptability to different surface conditions of the ground. The purpose of this study was to clarify whether walking adaptability on an uneven surface by step is related to daily walking activity in patients after stroke. We involved 14 patients who had hemiparesis after stroke and 12 healthy controls. The poststroke patients were categorized as least (...) limited community ambulators or unlimited ambulators. For the uneven surface, the study used an artificial grass surface. The subjects repeated even surface walking and the uneven surface walking trials at least two times at a comfortable speed. We collected spatiotemporal and kinematic gait parameters on both the even and uneven surfaces using a three-dimensional motion analysis system. After we measured gait, the subjects wore an accelerometer around the waist for at least 4 days. We measured the number of steps per day using the accelerometer to evaluate walking activity. Differences in gait parameters between the even and uneven surfaces were calculated to determine how the subjects adapted to an uneven surface while walking. We examined the association between the difference in parameter measurements between the two surface properties and walking activity. Walking activity significantly and positively correlated with the difference in paretic step length under the conditions of different surface properties in the poststroke patients and step width in the healthy controls. The strategy of increasing the paretic step length, but not step width, on an uneven surface may lead to a larger base of support, which maintains stability during gait on an uneven surface in poststroke patients, resulting in an increased walking activity. Therefore, in poststroke patients, an increase in paretic step length during gait on an uneven surface might be more essential for improving walking activity. (shrink)

Although written in Japanese, 分析性について（On Analyticity） pursues the problem of analyticity discussed in philosophy of language from a Kantian perspective.

Young children generally learn words from other people. Recent research has shown that children can learn new actions and skills from nonhuman agents. This study examines whether young children could learn words from a robot. Preschool children were shown a video in which either a woman or a mechanical robot labeled novel objects. Then the children were asked to select the objects according to the names used in the video. The results revealed that children in the human condition were more (...) likely to select the correct objects than those in the robot condition. Nevertheless, the five-year-old children in the robot condition performed significantly better than chance level, while the four-year olds did not. Thus there is a developmental difference in children’s potential to learn words from a robot. The results contribute to our understanding of how children interact with non-human agents. Keywords: developmental cybernetics; word learning; social cognition; cognitive development. (shrink)

Not a few feminist writers, such as Kristeva, Irigaray, and Chodorow, have dealt with Freud’s psychoanalysis so far, but it is not clear to what degree the Freudian theory grounds their arguments, because Freud himself developed his psychoanalysis mainly for the male mental world (Seelenleben). In this paper, we shall follow Freud’s train of thought exclusively from this angle. After the geneses of Pcpt.-Cs., id, ego, and super-ego (W-Bw, Es, Ich, and Über-Ich, respectively) are treated (§§7-10), we shed light on (...) how these factors relate to the female spirituality (§§11-24) and why feminists could still rely on Freud’s thought (§25). On the other hand, the present research will also provide an easy introduction to Freud’s psychoanalysis, by reference to which each thinker could overview the Freudian theory (Fig. (5) and Fig. (8) will help). In this respect, we shall also take account of the masculine side of his discussion, that is to say, how a man usually develops his male personality, while we constantly put it in stark contrast to the female spirituality. Although, in this modern world, not a few thinkers criticize the Freudian theory as non-scientific like Popper did (§2), we should remember that there remain supporters of his theory, such as Grümbaum (§3). We shall touch on this kind of argument relating to philosophy of science in the first half of this paper, which will also provide some useful knowledge for the readers who still get doubtful of the Freudian theory and its usage in feminist arguments. (shrink)

Written in Japanese, the overall picture of the thoughts of modern philosophers, namely Hume, Kant, and Mill, is put forward.

Although written in Japanese, this article deals with what the gender theory is all about by reference to Beauvoir's Le Deuxième Sexe. Sartre's works are also heavily cited to clarify the background of Beauvoir's philosophy.

“정치적인 것” 또는 “정치적임”(the political)은 칼 슈미트 정치이론에서 핵심적 역할을 하는 개념이다. 친구와 적을 실존적으로 구분하는 것을 이 개념논리의 핵심으로 간주하고, 모든 서구 근대 국가정치이론의 권력개념의 근간을 서구신학에서 찾고 있는 슈미트의 정치신학적 사유는 많은 논란과 함께 오랫동안 널리 논의되고 다양하게 해석되어 왔다. 한편, 우리는 자칭 최고형태의 형이상학이자 철학운동의 한 형태인 후썰현상학 체계 전반을 관통하는 일종의 “구조적 정치성”이 있음을 발견한다. 특히 후썰식 현상학적 주체와 비판 개념의 형이상학적 이론구조는 “정치적”이라는 개념으로 표상되고 파악되는 특성을 분명히 보이고 있다. 이러할 때, 우리는 슈미트식 정치 개념과 (...) 논리가 우리가 후썰현상학의 형이상학적 움직임을 구조적으로 동기적으로 추동하고 있는 것으로 보고 있는 그 정치성을 드러내게 하는데 유용한 관찰과 분석의 도구적 틀을 제공할 수 있음을 본다. 이 논문은 후썰이론 전반에 걸쳐 중심적인 이론적 역할을 담당하는 현상학적 주체-원험(原驗)적 초월자 주체(transcendental ideal subject) — 에 존재론적 ․ 구조적으로 내재하고 있는 일종의 분명한 정치적성(politicality)을 가시화하고자 하며, 그 작업에서 슈미트를 어떻게 전략적으로 유용할 수 있는지 보여주고자 한다. (shrink)

One can work for another person, probably for all the others in an ethical way, and not for money. This is the main idea pursued in this article. When it comes to labour, we are inclined to deal with Marx. But even Marx apparently did not notice this ethical side of labour, because his focus was mainly on the creation of value, which was common among thinkers at that time, such as Locke and Smith. In contrast, Hegel consistently tackled the (...) same issue from another angle: ethics. In terms of this, he went so far as to say the dignity of humans should be located in labour. We shed light on this very aspect of Hegel’s philosophy by reference to Alexandre Kojève’s famous commentary, Introduction à la lecture de Hegel. (shrink)

This study aims to explicate interviewer and candidate conversational practices in L2 job interviews as they relate to the assessment of a candidate’s qualification for a particular position. The data consisted of 27 audio-recorded job interviews for the position of student assistant in English classes at a Japanese university. The analysis of these interactional data, conducted using conversational analysis methodology, revealed that the inadequacy of a candidate’s response is constructed by means of the interviewer’s subsequent pursuit of a relevant answer (...) from the candidate. In addition, a candidate’s ability to build rapport by providing sequentially linked joke-serious responses evoked a positive evaluation from the interviewer. The findings indicate that a candidate’s understanding of expected behaviors and ability to accommodate his or her behaviors in a manner relevant to the interaction result in a positive assessment. (shrink)

The aim of this paper is to apply inductive logic to the field that, presumably, Carnap never expected: legal causation. Legal causation is expressible in the form of singular causal statements; but it is distinguished from the customary concept of scientific causation, because it is subjective. We try to express this subjectivity within the system of inductive logic. Further, by semantic complement, we compensate a defect found in our application, to be concrete, the impossibility of two-place predicates (for causal relationship) (...) in inductive logic. (shrink)

The Internet was born in 1960’s, then Internet ethics appeared as a branch of information ethics. It seems, however, our status on the Net is not yet scrutinized. We investigate this problem with the help of philosophers like Dreyfus, Merleau-Ponty, and Austin.

Hans Jonas and Arne Næss have argued that philosophers need not be concerned with natural sciences even when they talk about enviromental issues like global warming (§1). However, believing sciences blindly is in itself unphilosophical. So we think, in this paper, the other way around: We consider the current view of global warming, which was reported by the IPCC, critically. The so-called AR4 is divided into two parts. One is about the industrial revolutions (§§5-9); the other is about the greenhouse (...) effect (§§11-20). Through this consideration, it will be revealed: the views of the Establishment are not at all absolute; there still remains room to reconsider them. (shrink)

Husserl’s phenomenology opens itself with a critique of positive sciences. Husserl problematizes the hardcore presupposition of positivism that the world is a definite sort of an existential totality of objects and thus it is exhaustible with empirical data and deductive-conceptual abstraction on the basis of causalspatio-temoprality. Criticizing the wholesome reduction of nature into a physical reality and the instrumentalizing of theoretical reason, he proposes transcendental phenomenology, as an ideal form of science. Self-entitled as the genuine science, the science of origin, (...) the science of all sciences, etc., it concerns itself with the matter of validity. Claiming that validating objectivity as such and the meaning of scientific objectification is something of which onlyphenomenological reflection on pure consciousness is capable and that the positivistic objectivity is and must be founded on transcendental subjectivity, Husserl radically idealistically revised the whole positivistic concept of evidence and givenness of a fact and substituted it with the phenomenological notion of apriori self-evidence and originary givenness of primordial intentional consciousness. Nevertheless, it is noticed that the absolute universal validity of positivistic objectivity was never rejected or questioned; objectivity is still in and of itself an absolute criterion of scientificity in Husserl. This paper will argue that the idealistic turn toward subjectivity takes place through factualization of transcendentality and this, by bestowing apriori apodicticity with facticity, even enhances more the supreme epistemological function of positivity. It will discuss such positivistic drive, directly bequeathed from the very cultural ethos at which phenomenological criticism targeted, as an important locomotive for Husserl’s program and point out an antinomical consequence with which it is to be faced as a consequence. (shrink)

The original interest of this article lies in existential import. It provides a broader view on the problem by reference to modern, symbolic logic (ch.1). Gradually, however, our interest will change into the amalgamated expressions often used in logic; that is, why are such expressions as “x is a round triangle” applied in logic? We critically discuss this question from an extensional viewpoint, namely model theoretic semantics (ch.2). We also touch on Church’s λ-calculus in the appendix (app.2).

Although we often see references to Carnap’s inductive logic even in modern literatures, seemingly its confusing style has long obstructed its correct understanding. So instead of Carnap, in this paper, I devote myself to its necessary and sufficient commentary. In the beginning part (Sections 2-5), I explain why Carnap began the study of inductive logic and how he related it with our thought on probability (Sections 2-4). Therein, I trace Carnap’s thought back to Wittgenstein’s Tractatus as well (Section 5). In (...) the succeeding sections, I attempt the simplest exhibition of Carnap’s earlier system, where his original thought was thoroughly provided. For this purpose, minor concepts to which researchers have not paid attention are highlighted, for example, m-function (Section 8), in-correlation (Section 10), C-correlate (Section 10), statistical distribution (Section 12), and fitting sequence (Section 17). The climax of this paper is the proof of theorem (56). Through this theorem, we will be able to overview Carnap’s whole system. (shrink)

The aim of this paper is to call the attention, especially that of feminists, to the current progress in biology. It appears gender studies still confine themselves to outdated ideas of sex chromosomes like XX, XY (§10). However, science has been making progress. It no longer sticks to such matters as XX, XY. Its interest is now in Sry, a kind of gene (§11), and MIS, a kind of sex hormone (§14). Abnormalities of sex chromosomes are no longer evidence to (...) deny the biological approaches, for example. We shed light on this fact, putting gender studies in the context of chronologies of science as well (§§2-9). (shrink)

The concept and the logic of the political, the most notable Schmittian ideas, based on the friend/enemy distinction and his thought on political theology have been widely and critically discussed and actively appropriated with various interpretations. On the other hand, we find that there is certain definite momentum piercing through the theoretical structure of Husserl’s phenomenology in general both as a form of metaphysics and as a philosophical movement, which can also be called the political. In this circumstance, we find (...) the Schmittian logic of the political together with his idea of political theology specifically serviceable for an effective visualization of the political characteristically structured in Husserl’s system, particularly in the concepts of transcendental subjectivity and universal critique. This paper argues that Husserl’s phenomenological critical subject is fundamentally a politico-theological subject and is an attempt to show to what extent and in what way Schmitt can be strategically utilized to make manifest the politicality that we discover as something that structurally inheres in Husserlian notion of subjectivity and critique. *. (shrink)

Although written in Japanese, an overall picture of quantum physics is drawn, which would surely be useful for beginners as well as researchers of the humanities.