Malignant cells are characterized by an increased content of endogenous formaldehyde formed as a by‐product of biosynthetic processes. Accumulation of formaldehyde in cancer cells is combined with activation of the processes of cellular formaldehyde clearance. These mechanisms include increased ALDH and suppressed ADH5/FDH activity, which oncologists consider poor and favorable prognostic markers, respectively. Here, the sources and regulation of formaldehyde metabolism in cancer cells are reviewed. The authors also analyze the participation of oncoproteins such as fibulins, FGFR1, HER2/neu, FBI‐1, and (...) MUC1‐C in the control of genes related to formaldehyde metabolism, suggesting the existence of two mutually exclusive processes in cancer cells: 1) production and 2) oxidation and elimination of formaldehyde from the cell. The authors hypothesize that the study of the anticancer properties of disulfiram and alpha lipoic acid – which affect the balance of formaldehyde in the body – may serve as the basis of future anticancer therapy. (shrink)

In spite of the fact that true arithmetic reduces to the monadic second-order theory of the real line, Peano arithmetic cannot be interpreted in the monadic second-order theory of the real line.

In this paper I develop three different arguments against the thesis that knowledge-how is a kind of knowledge-that. Knowledge-that is widely thought to be subject to an anti-luck condition, a justified or warranted belief condition, and a belief condition, respectively. The arguments I give suggest that if either of these standard assumptions is correct then knowledge-how is not a kind of knowledge-that. In closing I identify a possible alternative to the standard Rylean and intellectualist accounts of knowledge-how. This alternative view (...) illustrates that even if the arguments given here succeed it might still be reasonable to hold that knowing how to do something is a matter of standing in an intentional relation to a proposition other than the knowledge-that relation. (shrink)

Although considerations based on contemporary space-time theories, such as special and general relativity, seem highly relevant to the debate about persistence, their significance has not been duly appreciated. My goal in this paper is twofold: (1) to reformulate the rival positions in the debate (i.e., endurantism [three-dimensionalism] and perdurantism [four-dimensionalism, the doctrine of temporal parts]) in the framework of special relativistic space-time; and (2) to argue that, when so reformulated, perdurantism exhibits explanatory advantages over endurantism. The argument builds on the (...) fact that four-dimensional entities extended in space as well as time are relativistically invariant in a way three-dimensional entities are not. (shrink)

Automated classification of legal documents has been the subject of extensive research in recent years. However, this is still a challenging task for long documents, since it is difficult for a model to identify the most relevant information for classification. In this paper, we propose a two-stage supervised learning approach for the classification of petitions, a type of legal document that requests a court order. The proposed approach is based on a word-level encoder–decoder Seq2Seq deep neural network, such as a (...) Bidirectional Long Short-Term Memory (BiLSTM) or a Bidirectional Encoder Representations from Transformers (BERT) model, and a document-level Support Vector Machine classifier. To address the challenges posed by the lengthy legal documents, the approach introduces a human-in-the-loop approach, whose task is to localize and tag relevant segments of text in the word-level training part, which dramatically reduces the dimension of the document classifier input vector. We performed experiments to validate our approach using a real-world dataset comprised of 270 intermediate petitions, which were carefully annotated by specialists from the 15th civil unit of the State of Alagoas, Brazil. Our results revealed that both BiLSTM and BERT-Convolutional Neural Networks variants achieved an accuracy of up to 95.49%, and also outperformed baseline classifiers based on the Term Frequency–Inverse Document Frequency test vectorizer. The proposed approach is currently being utilized to automate the aforementioned justice unit, thereby increasing its efficiency in handling repetitive tasks. (shrink)

This ambitious book looks into the reasons for the exceptional durability of the Chinese empire, which lasted for more than two millennia (221 B.C.E. - 1911 C.E.). Yuri Pines identifies the roots of the empire's longevity in the activities of thinkers of the Warring States period (453-221 B.C.E.), who, in their search for solutions to an ongoing political crisis, developed ideals, values, and perceptions that would become essential for the future imperial polity. In marked distinction to similar empires worldwide, (...) the Chinese empire was envisioned and to a certain extent 'preplanned' long before it came into being. As a result, it was not only a military and administrative construct, but also an intellectual one. Pines makes the argument that it was precisely its ideological appeal that allowed the survival and regeneration of the empire after repeated periods of turmoil. "Envisioning Eternal Empire" presents a panoptic survey of philosophical and social conflicts in Warring States political culture. By examining the extant corpus of preimperial literature, including transmitted texts and manuscripts uncovered at archaeological sites, Pines locates the common ideas of competing thinkers that underlie their ideological controversies. This bold approach allows him to transcend the once fashionable perspective of competing 'schools of thought' and show that beneath the immense pluralism of Warring States thought one may identify common ideological choices that eventually shaped traditional Chinese political culture. The result is a refreshingly novel look at the foundational period in Chinese intellectual history. (shrink)

A recent debate has ensued over the claim in Pikovski et al. that systems with internal degrees of freedom undergo a universal, gravity-induced, type of decoherence that explains their quantum-to-classical transition. Such decoherence is supposed to arise from the different gravitational redshifts experienced by such systems when placed in a superposition of two wave packets at different heights in a gravitational field. Here we investigate some aspects of the discussion with the aid of simple examples. In particular, we first resolve (...) an apparent conflict between the reported results and the equivalence principle by noting that the static and free fall descriptions focus on states associated with different hypersurfaces. Next, we emphasize that predictions regarding the observability of interference become relevant only in the context of concrete experimental settings. As a result, we caution against hasty claims of universal validity. Finally, we dispute the claim that, at least in the scenarios discussed in Pikovski et al., gravitation is responsible for the reported results and we question the alleged ability of decoherence to explain the quantum-to-classical transition. In consequence, we argue against the extraordinary assertion in Pikovski et al. that gravity can account for the emergence of classicality. (shrink)

Name der Zeitschrift: Klio Jahrgang: 99 Heft: 2 Seiten: 513-527.

RESUMO É cada vez mais sensível a grande profusão de distintas formas de narratividade biográfica na sociedade contemporânea. A partir do que apresentam pesquisas em diferentes campos dos estudos em linguagem, faz-se incontestável a heterogenericidade com que diversas formas de narração do eu em diferentes tons de autorreferência têm insurgido numa sociedade altamente midiatizada e globalizada. Nesse entrever, ancorados no edifício teórico da análise dialógica do discurso em confluência com estudos que se debruçam sobre as escritas de si, propomo-nos a (...) discutir a ressignificação como ato característico do movimento de autorreferência constitutivo da autobiografia e de algumas outras formas de narrativas do eu. Dentre outras observações, destacamos, na construção discursiva de textos autorreferentes, como a autobiografia, um entrecruzamento entre sentidos, memórias e vivências em uma relação de ressignificação sob a luz do que o sujeito não só foi como agora é. ABSTRACT The great profusion of different forms of biographical narrativity in contemporary society is increasingly sensitive. From what is presented by studies in different fields of language studies, the heterogeneity with which diverse forms of narration of the self in different tones of self-reference have emerged in a highly mediatized and globalized society becomes indisputable. Therefore, anchored in the theoretical propositions of the dialogic analysis of discourse along with studies that focus on life writings, we discuss re-signification as a characteristic act of the movement of self-reference, constitutive of autobiographies and some other forms of narratives of the self. Among other observations, we highlight in the discursive construction of self-referential texts, such as autobiography, a cross-linking between senses, memories and life experiences in their relation of re-signification in the light of what the subject not only was, but is now. (shrink)

This article examines the method of reflective equilibrium (RE) and its role in philosophical inquiry. It begins with an overview of RE before discussing some of the subtleties involved in its interpretation, including challenges to the standard assumption that RE is a form of coherentism. It then evaluates some of the main objections to RE, in particular, the criticism that this method generates unreasonable beliefs. It concludes by considering how RE relates to recent debates about the role of intuitions in (...) philosophy. (shrink)

Is there a successful regress argument against intellectualism? In this article I defend the negative answer. I begin by defending Stanley and Williamson's (2001) critique of the contemplation regress against Noë (2005). I then identify a new argument – the employment regress – that is designed to succeed where the contemplation regress fails, and which I take to be the most basic and plausible form of a regress argument against intellectualism. However, I argue that the employment regress still fails. Drawing (...) on the previous discussion, I criticise further regress arguments given by Hetherington (2006) and Noë (2005). (shrink)

How should intellectualists respond to apparent Gettier-style counterexamples? Stanley offers an orthodox response which rejects the claim that the subjects in such scenarios possess knowledge-how. I argue that intellectualists should embrace a revisionary response according to which knowledge-how is a distinctively practical species of knowledge-that that is compatible with Gettier-style luck.

It is often said that ‘what it is like’-knowledge cannot be acquired by consulting testimony or reading books [Lewis 1998; Paul 2014; 2015a]. However, people also routinely consult books like What It Is Like to Go to War [Marlantes 2014], and countless ‘what it is like’ articles and youtube videos, in the apparent hope of gaining knowledge about what it is like to have experiences they have not had themselves. This article examines this puzzle and tries to solve it by (...) appealing to recent work on knowing-wh ascriptions. In closing I indicate the wider significance of these ideas by showing how they can help us to evaluate prominent arguments by Paul [2014; 2015a] concerning transformative experiences. (shrink)

Any acceptable quantum gravity theory must allow us to recover the classical spacetime in the appropriate limit. Moreover, the spacetime geometrical notions should be intrinsically tied to the behavior of the matter that probes them. We consider some difficulties that would be confronted in attempting such an enterprise. The problems we uncover seem to go beyond the technical level to the point of questioning the overall feasibility of the project. The main issue is related to the fact that, in the (...) quantum theory, it is impossible to assign a trajectory to a physical object, and, on the other hand, according to the basic tenets of the geometrization of gravity, it is precisely the trajectories of free localized objects that define the spacetime geometry. The insights gained in this analysis should be relevant to those interested in the quest for a quantum theory of gravity and might help refocus some of its goals. (shrink)

У статті аналізуються проблеми конфесійної ідентичності віруючих українського православ'я в умовах сучасних цивілізаційних викликів. Встановлено, що для значної кількості віруючих належність до етноконфесійної спільноти не є базовим ідентифікатом, тому самодекларація ідентифікації з православною конфесією значною мірою має номінальний характер, зумовлена сприйняттям православ'я як культурної традиції.

This article attempts to outline some critical aspects of the accelerationist movement. More specifically, it argues that light can be shed on key aspects of the political proposals of Williams and Srnicek by considering them from the perspective of the socio-political reflections of both Lacan and Deleuze and Guattari. Anti-Oedipus is one crucial starting point for accelerationist thinking, in terms of the concept of the ‘machinic’ and the explicit reference to ‘acceleration’, but it is equally obvious that Lacan has been (...) an important figure in the debate on the topic of ‘desire’. Likewise, and for the same reasons, accelerationism offers the potential for a fruitful reconsideration of Deleuzian philosophy, and of the difficult relationship between schizo- analysis and psycho-analysis. We argue that, in the light of accelerationism, the perspectives of Deleuze and Guattari and Lacan do converge, in particular around the theoretical articulation of the concept of the ‘political’. Accelerationism, as many critics have noted, has numerous implications in the field of subjectivity and often falls into a general plea for a strong neo-Enlightenment. Hence we will attempt to explicate these implications by attempting to read accelerationism via the psychoanalytic categories of jouissance and fantasy. This last category, as Stavrakakis has shown, is directly linked to the political category of ‘Utopia’, and therefore provides an adequate theoretical basis for such a psychoanalytic reading of accelerationism. Should accelerationism be considered the only way out of the socio-political constraints of neoliberalism today? However we approach this question, the argument pursued here is that the best starting points for a critique of accelerationism are the concepts of jouissance, the state/capital relationship, schizo-analysis and paranoid ways of functioning. (shrink)

The majority of higher plants (including almost all important crops) demonstrate strict uniparental maternal inheritance of plasmagenes in the process of conventional sexual crossing; it is therefore impossible to generate heterozygosity for these genes with standard crossing procedures. However, recent experiments have shown that hybrid plants can be produced by somatic cell fusion and that these contain the cytoplasmic genes of both parents. The phenotypic and genetic properties of these hybrid plants are described here.

In the current era of the Sustainable Development Goals, many countries are attempting to strengthen their health system and achieving Universal Health Coverage. The Korean National Health Insurance system functions as a core element of health financing, contributing to achieving UHC by promoting public health and social security through insurance benefits for prevention, diagnosis, treatment, rehabilitation, childbirth, and health promotion. The Republic of Korea achieved 100% NHI coverage of the target population in 1989, 12 years after the introduction of the (...) social insurance system. However, poor coverage of health services and lack of financial protection are major obstacles to achieving UHC. Therefore, the Korean government announced and implemented ‘Moon Jae-in Care’ in August 2017 to enhance the coverage rate of NHI by 70%. First, this study reviews the existing health insurance system in Korea from the perspective of health financing and UHC. Second, it analyses ‘Moon Jae-in Care’, based on the main framework of UHC. Third, it considers the ethical implications of these developments, with focus on the principles of equity, fairness, autonomy, and solidarity. Although the NHI reform is expected to propel Korean health care closer to UHC, many ethical, social, and political issues remain. (shrink)

The author analyses some problems discussed in the article of Vadim Mezhuev. He discusses the ways in which historians deal with their own scientific problems in the light of philosophical problems of sciences. According to Yu. Nikiforov, a philosopher can always talk about the future which is yet to come; a historian sees the future through the present of the processes which she describes. The author argues that a reconstruction of the past is always based on the knowledge of the (...) present. (shrink)

How can Euler diagrams support non-consequence inferences? Although an inference to non-consequence, in which people are asked to judge whether no valid conclusion can be drawn from the given premises, is one of the two sides of logical inference, it has received remarkably little attention in research on human diagrammatic reasoning; how diagrams are really manipulated for such inferences remains unclear. We hypothesized that people naturally make these inferences by enumerating possible diagrams, based on the logical notion of self-consistency, in (...) which every Euler diagram is true in a set-theoretical interpretation. The work is divided into three parts, each exploring a particular condition or scenario. In condition 1, we asked participants to directly manipulate diagrams with size-fixed circles as they solved syllogistic tasks, with the result that more reasoners used the enumeration strategy. In condition 2, another type of size-fixed diagram was used. The diagram layout change interfered with accurate task performances and with the use of the enumeration strategy; however, the enumeration strategy was still dominant for those who could correctly perform the tasks. In condition 3, we used size-scalable diagrams, which reduced the interfering effect of diagram layout and enhanced participants’ selection of the enumeration strategy. These results provide evidence that non-consequence inferences can be achieved by diagram enumeration, exploiting the self-consistency of Euler diagrams. An alternate strategy based on counter-example construction with Euler diagrams, as well as effects of diagram layout in inferential processes, are also discussed. (shrink)

Previous work suggests that Asians allocate more attention to configuration information than Caucasian Americans do. Yet this cultural variation has been found only with stimuli such as natural scenes and objects that require both feature- and configuration-based processing. Here, we show that the cultural variation also exists in face perception—a domain that is typically viewed as configural in nature. When asked to identify a prototypic face for a set of disparate exemplars, Japanese were more likely than Caucasian Americans to use (...) overall resemblance rather than feature matching. Moreover, in a speeded identity-matching task, Japanese were more accurate than Americans in identifying the spatial configuration of features (e.g., eyes). Together, these findings underscore the robustness of culture’s influences on cognition. (shrink)

Yuri Balashov sets out major rival views of persistence--endurance, perdurance, and exdurance--in a spacetime framework and proceeds to investigate the implications of Einstein's theory of relativity for the debate about persistence. His overall conclusion--that relativistic considerations favour four-dimensionalism over three-dimensionalism--is hardly surprising. It is, however, anything but trivial. Contrary to a common misconception, there is no straightforward argument from relativity to four-dimensionalism. The issues involved are complex, and the debate is closely entangled with a number of other philosophical disputes, (...) including those about the nature and ontology of time, parts and wholes, material constitution, causation and properties, and vagueness. (shrink)

The success of deep learning in natural language processing raises intriguing questions about the nature of linguistic meaning and ways in which it can be processed by natural and artificial systems. One such question has to do with subword segmentation algorithms widely employed in language modeling, machine translation, and other tasks since 2016. These algorithms often cut words into semantically opaque pieces, such as ‘period’, ‘on’, ‘t’, and ‘ist’ in ‘period|on|t|ist’. The system then represents the resulting segments in a dense (...) vector space, which is expected to model grammatical relations among them. This representation may in turn be used to map ‘period|on|t|ist’ (English) to ‘par|od|ont|iste’ (French). Thus, instead of being modeled at the lexical level, translation is reformulated more generally as the task of learning the best bilingual mapping between the sequences of subword segments of two languages; and sometimes even between pure character sequences: ‘p|e|r|i|o|d|o|n|t|i|s|t’ → ‘p|a|r|o|d|o|n|t|i|s|t|e’. Such subword segmentations and alignments are at work in highly efficient end-to-end machine translation systems, despite their allegedly opaque nature. The computational value of such processes is unquestionable. But do they have any linguistic or philosophical plausibility? I attempt to cast light on this question by reviewing the relevant details of the subword segmentation algorithms and by relating them to important philosophical and linguistic debates, in the spirit of making artificial intelligence more transparent and explainable. (shrink)