Results for 'YENPTY domain'

976 found
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  1.  18
    The – YENPTYdomain of the amyloid precursor protein: Much more than just endocytosis? ( C omment on DOI 10.1002/bies.201300041). [REVIEW]Hoang S. Nhan & Edward H. Koo - 2013 - Bioessays 35 (10):844-844.
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  2.  45
    A new molecular explanation for age‐related neurodegeneration: The Tyr682 residue of amyloid precursor protein.Carmela Matrone - 2013 - Bioessays 35 (10):847-852.
    Emerging evidence supports the role for the intracellular domains of amyloid precursor protein (APP) in the physiology and function of APP. In this short report, I discuss the hypothesis that mutation of Tyr682 on the Y682ENPTY687 C‐terminal motif of APP may be directly or indirectly associated with alterations in APP functioning and activity, leading to neuronal defects and deficits. Mutation of Tyr682 induces an early and progressive age‐dependent cognitive and locomotor decline that is associated with a loss of synaptic connections, (...)
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  3.  16
    Ab initio atomic-scale determination of point-defect structure in hcp zirconium.C. Domain * & A. Legris - 2005 - Philosophical Magazine 85 (4-7):569-575.
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  4.  20
    Ab initio calculations of some atomic and point defect interactions involving C and N in Fe.C. S. Becquart *, C. Domain & J. Foct - 2005 - Philosophical Magazine 85 (4-7):533-540.
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  5.  15
    Ab initio atomic-scale modelling of iodine effects on hcp zirconium.A. Legris * & C. Domain - 2005 - Philosophical Magazine 85 (4-7):589-595.
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  6. The forty-fourth annual lecture series 2003–2004.Are Infants Little Scientists & Rethinking Domain-Specificity - 2003 - Journal for General Philosophy of Science / Zeitschrift für Allgemeine Wissenschaftstheorie 34 (413).
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  7.  27
    Molecular dynamics simulations of damage and plasticity: The role ofab initiocalculations in the development of interatomic potentials.C. S. Becquart & C. Domain - 2009 - Philosophical Magazine 89 (34-36):3215-3234.
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  8.  20
    Ab initio atomic-scale determination of point-defect structure in hcp zirconium.C. Domain & A. Legris - 2005 - Philosophical Magazine 85 (4-7):569-575.
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  9.  17
    Ab initio atomic-scale modelling of iodine effects on hcp zirconium.A. Legris & C. Domain - 2005 - Philosophical Magazine 85 (4-7):589-595.
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  10.  20
    Constitutive Aspects of Morality.Moral Domain - 2005 - In Wolfgang Edelstein & Gertrud Nunner-Winkler, Morality in context. Boston: Elsevier. pp. 137--25.
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  11. George Khushf.The Domain of Parental Discretion in Treatment - 2002 - In Julia Lai Po-Wah Tao, Cross-cultural perspectives on the (im) possibility of global bioethics. Boston: Kluwer Academic.
     
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  12. Contrastes 11.Domaine Français Et la PassiviteItalien & I. Comprehension Et Interpretation - 1985 - Contrastes: Revue de l'Association Pour le Developpement des Études Contrastives 10:11.
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  13.  19
    Ab initio calculations of some atomic and point defect interactions involving C and N in Fe.C. S. Becquart, C. Domain & J. Foct - 2005 - Philosophical Magazine 85 (4-7):533-540.
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  14.  31
    Comparison between three complementary approaches to simulate ' large ' fluence irradiation: application to electron irradiation of thin foils.A. Barbu, C. S. Becquart, J. L. Bocquet, J. Dalla Torre & C. Domain - 2005 - Philosophical Magazine 85 (4-7):541-547.
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  15.  46
    Comparison between three complementary approaches to simulate ‘ large ’ fluence irradiation: application to electron irradiation of thin foils.A. Barbu *, C. S. Becquart, J. L. Bocquet, J. Dalla Torre & C. Domain - 2005 - Philosophical Magazine 85 (4-7):541-547.
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  16.  14
    Comparison of algorithms for multiscale modelling of radiation damage in Fe–Cu alloys.L. Malerba *, C. S. Becquart, M. Hou & C. Domain - 2005 - Philosophical Magazine 85 (4-7):417-428.
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  17.  7
    A Framework to Integrate Ethical, Legal, and Societal Aspects (ELSA) in the Development and Deployment of Human Performance Enhancement (HPE) Technologies and Applications in Military Contexts.Human Behaviour Marc Steen Koen Hogenelst Heleen Huijgen A. Tno, The Hague Collaboration, Human Performance The Netherlandsb Tno, The Netherlandsc Tno Soesterberg, Aerospace Warfare Surface, The NetherlAndsmarc Steen Works As A. Senior Research ScientIst At Tno The Hague, Value-Sensitive Design Human-Centred Design, Virtue Ethics HIs Mission is To Promote The Design Applied Ethics Of Technology, Flourish Koen Hogenelst Works As A. Senior Research Scientist at Tno ApplicAtion Of Technologies In Ways That Help To Create A. Just Society In Which People Can Live Well Together, His Research COncentrates on Measuring A. Background In Neuroscience, Cognitive Performance Improving Mental Health, Military Domains HIs Goal is To Align Experimental Research In Both The Civil, Field-Based Research Applied, Practical Use To Pave The Way For Implementation, Consultant At Tno Impact Heleen Huijgen Is A. Legal Scientist & StrAtegic Environment Her MIssion is To Create Legal Safeguards Fo Technologies - 2025 - Journal of Military Ethics 23 (3):219-244.
    In order to maximize human performance, defence forces continue to explore, develop, and apply human performance enhancement (HPE) methods, ranging from pharmaceuticals to (bio)technological enhancement. This raises ethical, legal, and societal concerns and requires organizing a careful reflection and deliberation process, with relevant stakeholders. We discuss a range of ethical, legal, and societal aspects (ELSA), which people involved in the development and deployment of HPE can use for such reflection and deliberation. A realistic military scenario with proposed HPE application can (...)
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  18.  19
    Comparison of algorithms for multiscale modelling of radiation damage in Fe-Cu alloys.L. Malerba, C. S. Becquart, M. Hou & C. Domain - 2005 - Philosophical Magazine 85 (4-7):417-428.
  19.  47
    In Defense of a Self-Disciplined, Domain-Specific Social Contract Theory of Business Ethics.Ben Wempe - 2005 - Business Ethics Quarterly 15 (1):113-135.
    Abstract:This article sets out two central theses. Both theses primarily involve a fundamental criticism of current contractarian business ethics (CBE), but if these can be sustained, they also constitute two boundary conditions for any future contractarian theory of business ethics. The first, which I label the self-discipline thesis, claims that current CBE would gain considerably in focus if more attention were paid to the logic of the social contract argument. By this I mean the aims set by the theorist and (...)
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  20. (1 other version)Corporate Social Responsibility: A Three-Domain Approach.Mark S. Schwartz & Archie B. Carroll - 2003 - Business Ethics Quarterly 13 (4):503-530.
    Abstract:Extrapolating from Carroll’s four domains of corporate social responsibility (1979) and Pyramid of CSR (1991), an alternative approach to conceptualizing corporate social responsibility (CSR) is proposed. A three-domain approach is presented in which the three core domains of economic, legal, and ethical responsibilities are depicted in a Venn model framework. The Venn framework yields seven CSR categories resulting from the overlap of the three core domains. Corporate examples are suggested and classified according to the new model, followed by a (...)
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  21. What makes interdisciplinarity difficult? Some consequences of domain specificity in interdisciplinary practice.Miles MacLeod - 2018 - Synthese 195 (2):697-720.
    Research on interdisciplinary science has for the most part concentrated on the institutional obstacles that discourage or hamper interdisciplinary work, with the expectation that interdisciplinary interaction can be improved through institutional reform strategies such as through reform of peer review systems. However institutional obstacles are not the only ones that confront interdisciplinary work. The design of policy strategies would benefit from more detailed investigation into the particular cognitive constraints, including the methodological and conceptual barriers, which also confront attempts to work (...)
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  22. Biodynamic Ontology: Applying BFO in the Biomedical Domain.Barry Smith, Pierre Grenon & Louis Goldberg - 2004 - Studies in Health and Technology Informatics 102:20–38.
    Current approaches to formal representation in biomedicine are characterized by their focus on either the static or the dynamic aspects of biological reality. We here outline a theory that combines both perspectives and at the same time tackles the by no means trivial issue of their coherent integration. Our position is that a good ontology must be capable of accounting for reality both synchronically (as it exists at a time) and diachronically (as it unfolds through time), but that these are (...)
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  23.  15
    Aristotle on Inquiry: Erotetic Frameworks and Domain Specific Norms.James G. Lennox - 2020 - New York, NY, USA: Cambridge University Press.
    Aristotle is a rarity in the history of philosophy and science - he is a towering figure in the history of both disciplines. Moreover, he devoted a great deal of philosophical attention to the nature of scientific knowledge. How then do his philosophical reflections on scientific knowledge impact his actual scientific inquiries? In this book James Lennox sets out to answer this question. He argues that Aristotle has a richly normative view of scientific inquiry, and that those norms are of (...)
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  24. From Artifacts to Human Lives: Investigating the Domain-Generality of Judgments about Purposes.Michael Prinzing, David Rose, Siying Zhang, Eric Tu, Abigail Concha, Michael Rea, Jonathan Schaffer, Tobias Gerstenberg & Joshua Knobe - forthcoming - Journal of Experimental Psychology General.
    People attribute purposes in both mundane and profound ways—such as when thinking about the purpose of a knife and the purpose of a life. In three studies (total N = 13,720 observations from N = 3,430 participants), we tested whether these seemingly very different forms of purpose attributions might actually involve the same cognitive processes. We examined the impacts of four factors on purpose attributions in six domains (artifacts, social institutions, animals, body parts, sacred objects, and human lives). Study 1 (...)
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  25.  43
    Concept Discovery in a Scientific Domain.Kevin Dunbar - 1993 - Cognitive Science 17 (3):397-434.
    The scientific reasoning strategies used to discover a new concept in a scientific domain were investigated in two studies. An innovative task in which subjects discover new concepts in molecular biology was used. This task was based upon one set of experiments that Jacob and Monod used to discover how genes are controlled, and for which they were awarded the Nobel prize. In the two studies reported in this article, subjects were taught some basic facts and experimental techniques in (...)
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  26. Zagzebski on Authority and Preemption in the Domain of Belief.Arnon Keren - 2014 - European Journal for Philosophy of Religion 6 (4):61-76.
    The paper discusses Linda Zagzebski's account of epistemic authority. Building on Joseph Raz's account of political authority, Zagzebski argues that the basic contours of epistemic authority match those Raz ascribes to political authority. This, it is argued, is a mistake. Zagzebski is correct in identifying the pre-emptive nature of reasons provided by an authority as central to our understanding of epistemic authority. However, Zagzebski ignores important differences between practical and epistemic authority. As a result, her attempt to explain the rationality (...)
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  27. Abstract Objects and the Core-Periphery Distinction in the Ontological and the Conceptual Domain of Natural Language.Friederike Moltmann - 2020 - In José Luis Falguera & Concha Martínez-Vida, Abstract Objects: For and Against. Springer. pp. 255-276.
    This paper elaborates distinctions between a core and a periphery in the ontological and the conceptual domain associated with natural language. The ontological core-periphery distinction is essential for natural language ontology and is the basis for the central thesis of my 2013 book Abstract Objects and the Semantics of Natural Language, namely that natural language permits reference to abstract objects in its periphery, but not its core.
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  28.  56
    Leibniz, Kant, and Referring in the Quantum Domain.Cord Friebe - 2022 - Journal for General Philosophy of Science / Zeitschrift für Allgemeine Wissenschaftstheorie 53 (3):275-290.
    The paper addresses the referring problem in quantum mechanics, by spelling out the alternatives with complete or individual concepts, with directly referential labels, and with intuition. The connection between the way of referring and some metaphysical theses about objects will be explained. Then, the paper intends to make plausible that the Kantian way is the best way for the quantum domain, including quantum field theories.
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  29. Stabilizing Constructs through Collaboration across Different Research Fields as a Way to Foster the Integrative Approach of the Research Domain Criteria (RDoC) Project.Jacqueline A. Sullivan - 2016 - Frontiers in Human Neuroscience (00):00.
    In this article, I explain why stabilizing constructs is important to the success of the Research Domain Criteria Project and identify one measure for facilitating such stability.
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  30.  58
    Explainable AI in the military domain.Nathan Gabriel Wood - 2024 - Ethics and Information Technology 26 (2):1-13.
    Artificial intelligence (AI) has become nearly ubiquitous in modern society, from components of mobile applications to medical support systems, and everything in between. In societally impactful systems imbued with AI, there has been increasing concern related to opaque AI, that is, artificial intelligence where it is unclear how or why certain decisions are reached. This has led to a recent boom in research on “explainable AI” (XAI), or approaches to making AI more explainable and understandable to human users. In the (...)
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  31. The nature of moral judgements and the extent of the moral domain.Ben Fraser - 2012 - Philosophical Explorations 15 (1):1-16.
    A key question for research on the evolutionary origins of morality concerns just what the target of an evolutionary explanation of morality should be. Some researchers focus on behaviors, others on systems of norms, yet others on moral emotions. Richard Joyce (2006) offers an evolutionary explanation for the trait of making moral judgments. Here, I defend Joyce’s account of moral judgment against two objections from Stephen Stich (2008). Stich’s first objection concerns the supposed universality of moral judgments as Joyce conceives (...)
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  32.  24
    Spatializing Emotion: No Evidence for a Domain‐General Magnitude System.Benjamin Pitt & Daniel Casasanto - 2018 - Cognitive Science 42 (7):2150-2180.
    People implicitly associate different emotions with different locations in left-right space. Which aspects of emotion do they spatialize, and why? Across many studies people spatialize emotional valence, mapping positive emotions onto their dominant side of space and negative emotions onto their non-dominant side, consistent with theories of metaphorical mental representation. Yet other results suggest a conflicting mapping of emotional intensity (a.k.a., emotional magnitude), according to which people associate more intense emotions with the right and less intense emotions with the left (...)
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  33.  83
    Interpreting ordinary uses of psychological and moral terms in the AI domain.Hyungrae Noh - 2023 - Synthese 201 (6):1-33.
    Intuitively, proper referential extensions of psychological and moral terms exclude artifacts. Yet ordinary speakers commonly treat AI robots as moral patients and use psychological terms to explain their behavior. This paper examines whether this referential shift from the human domain to the AI domain entails semantic changes: do ordinary speakers literally consider AI robots to be psychological or moral beings? Three non-literalist accounts for semantic changes concerning psychological and moral terms used in the AI domain will be (...)
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  34.  33
    Total sets and objects in domain theory.Ulrich Berger - 1993 - Annals of Pure and Applied Logic 60 (2):91-117.
    Berger, U., Total sets and objects in domain theory, Annals of Pure and Applied Logic 60 91-117. Total sets and objects generalizing total functions are introduced into the theory of effective domains of Scott and Ersov. Using these notions Kreisel's Density Theorem and the Theorem of Kreisel-Lacombe-Shoenfield are generalized. As an immediate consequence we obtain the well-known continuity of computable functions on the constructive reals as well as a domain-theoretic characterization of the Heriditarily Effective Operations.
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  35.  66
    How “moral” are the principles of biomedical ethics? – a cross-domain evaluation of the common morality hypothesis.Markus Christen, Christian Ineichen & Carmen Tanner - 2014 - BMC Medical Ethics 15 (1):47.
    The principles of biomedical ethics – autonomy, non-maleficence, beneficence, and justice – are of paradigmatic importance for framing ethical problems in medicine and for teaching ethics to medical students and professionals. In order to underline this significance, Tom L. Beauchamp and James F. Childress base the principles in the common morality, i.e. they claim that the principles represent basic moral values shared by all persons committed to morality and are thus grounded in human moral psychology. We empirically investigated the relationship (...)
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  36.  21
    A large scale benchmark for session-based recommendations on the legal domain.Marcos Aurélio Domingues, Edleno Silva de Moura, Leandro Balby Marinho & Altigran da Silva - forthcoming - Artificial Intelligence and Law:1-36.
    The proliferation of legal documents in various formats and their dispersion across multiple courts present a significant challenge for users seeking precise matches to their information requirements. Despite notable advancements in legal information retrieval systems, research into legal recommender systems remains limited. A plausible factor contributing to this scarcity could be the absence of extensive publicly accessible datasets or benchmarks. While a few studies have emerged in this field, a comprehensive analysis of the distinct attributes of legal data that influence (...)
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  37. Elimination, not Reduction: Lessons from the Research Domain Criteria (RDoC) and Multiple Realisation.Tuomas K. Pernu - 2019 - Behavioral and Brain Sciences 42:e22.
    The thesis of multiple realisation that Borsboom et al. are relying on should not be taken for granted. In dissolving the apparent multiple realisation, the reductionist research strategies in psychopathology research (the Research Domain Criteria [RDoC] framework, in particular) are bound to lead to eliminativism rather than reductionism. Therefore, Borsboom et al. seem to be aiming at a wrong target.
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  38.  5
    Three Types of Existential Entailments in a Multi-domain Semantics.Dolf Rami & Jan Köpping - 2024 - Grazer Philosophische Studien 100 (4):467-522.
    In this article, we argue for the distinction of three different types of predicates: existence entailing, (existence) neutral, and nonexistence entailing predicates. We provide linguistic tests as well as examples to motivate this distinction. After motivating our views on predicates, we show how our theory is able to deal with a multitude of problematic data both known from the literature as well as new. Then, we develop a multi-domain predicate logic inspired by certain versions of free logics in order (...)
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  39.  38
    Symptom modelling can be influenced by psychiatric categories: choices for research domain criteria.Sam Fellowes - 2017 - Theoretical Medicine and Bioethics 38 (4):279-294.
    Psychiatric researchers typically assume that the modelling of psychiatric symptoms is not influenced by psychiatric categories; symptoms are modelled and then grouped into a psychiatric category. I highlight this primarily through analysing research domain criteria. RDoC’s importance makes it worth scrutinizing, and this assessment also serves as a case study with relevance for other areas of psychiatry. RDoC takes inadequacies of existing psychiatric categories as holding back causal investigation. Consequently, RDoC aims to circumnavigate existing psychiatric categories by directly investigating (...)
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  40. Strengths and Limitations of Formal Ontologies in the Biomedical Domain.Barry Smith - 2009 - Electronic Journal of Communication, Information and Innovation in Health 3 (1):31-45.
    We propose a typology of representational artifacts for health care and life sciences domains and associate this typology with different kinds of formal ontology and logic, drawing conclusions as to the strengths and limitations for ontology in a description logics framework. The four types of domain representation we consider are: (i) lexico-semantic representation, (ii) representation of types of entities, (iii) representations of background knowledge, and (iv) representation of individuals. We advocate a clear distinction of the four kinds of representation (...)
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  41.  61
    Word extension: A key to early word learning and domain-specificity.Sandra R. Waxman - 2001 - Behavioral and Brain Sciences 24 (6):1121-1122.
    Bloom provides a masterful synthesis of recent advances in word-learning, placing them within the framework of abiding theoretical issues. I will augment and challenge his approach by underscoring the significance of word extension for questions concerning (a) the origin and evolution of infants' expectations, and (b) domain-specificity in word-learning.
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  42.  26
    The CRP/MLP/TLP family of LIM domain proteins: Acting by connecting.Ralf Weiskirchen & Kalle Günther - 2003 - Bioessays 25 (2):152-162.
    In vertebrates, members of the cysteine‐rich protein (CRP) family are characterized by the presence of two LIM domains linked to short glycine‐rich repeats. These proteins mediate protein–protein interactions and are of fundamental importance for cell differentiation, cytoskeletal remodeling, and transcriptional regulation. To date, a vast amount of information about vertebrate CRPs has become available, including their biological functions, interacting partners, and three‐dimensional structures. Compatible with a molecular adapter role, structural data reveal that the LIM domains within these proteins represent completely (...)
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  43.  56
    The concept of the moral domain in moral foundations theory and cognitive developmental theory: Horses for courses?Bruce Maxwell & Guillaume Beaulac - 2013 - Journal of Moral Education 42 (3):360-382.
    Moral foundations theory chastises cognitive developmental theory for having foisted on moral psychology a restrictive conception of the moral domain which involves arbitrarily elevating the values of justice and caring. The account of this negative influence on moral psychology, referred to in the moral foundations theory literature as the ?great narrowing?, involves several interrelated claims concerning the scope of the moral domain construct in cognitive moral developmentalism, the procedure by which it was initially elaborated, its empirical grounds and (...)
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  44.  35
    The practical ethics of bias reduction in machine translation: why domain adaptation is better than data debiasing.Marcus Tomalin, Bill Byrne, Shauna Concannon, Danielle Saunders & Stefanie Ullmann - 2021 - Ethics and Information Technology 23 (3):419-433.
    This article probes the practical ethical implications of AI system design by reconsidering the important topic of bias in the datasets used to train autonomous intelligent systems. The discussion draws on recent work concerning behaviour-guiding technologies, and it adopts a cautious form of technological utopianism by assuming it is potentially beneficial for society at large if AI systems are designed to be comparatively free from the biases that characterise human behaviour. However, the argument presented here critiques the common well-intentioned requirement (...)
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  45.  33
    How to Identify Moral Experts? An Application of Goldman's Criteria for Expert Identification to the Domain of Morality.Martin Hoffmann - 2012 - Analyse & Kritik 34 (2):299-314.
    How can laypeople justifiably distinguish between reliable experts and unreliable experts? This problem, usually called the 'problem of expert identification', is highly debated in recent social epistemology. A great amount of work has been undertaken in order to find satisfactory criteria for identifying experts in different branches of the empirical sciences, but hardly in the domain of moral knowledge. This asymmetry between social and moral epistemology is the motivation behind my paper. I reconsider the epistemological problem of identifying moral (...)
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  46.  40
    Rationalization and Reflection Differentially Modulate Prior Attitudes Toward the Purity Domain.Ivar R. Hannikainen & Alejandro Rosas - 2019 - Cognitive Science 43 (6):e12747.
    Outside Western, predominantly secular‐liberal environments, norms restricting bodily and sexual conduct are widespread. Moralization in the so‐called purity domain has been treated as evidence that some putative violations are victimless. However, respondents themselves disagree: They often report that private yet indecent acts incur self‐harm, or harm to one's family and the wider community—a result which we replicate in Study 1. We then distinguish two cognitive processes that could generate a link between harmfulness and immorality, and recreate them in Studies (...)
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  47.  17
    Modeling Discontinuous Cultural Evolution: The Impact of Cross-Domain Transfer.Kirthana Ganesh & Liane Gabora - 2022 - Frontiers in Psychology 13.
    This paper uses autocatalytic networks to model discontinuous cultural transitions involving cross-domain transfer, using as an illustrative example, artworks inspired by the oldest-known uncontested example of figurative art: the carving of the Hohlenstein-Stadel Löwenmensch, or lion-human. Autocatalytic networks provide a general modeling setting in which nodes are not just passive transmitters of activation; they actively galvanize, or “catalyze” the synthesis of novel nodes from existing ones This makes them uniquely suited to model how new structure grows out of earlier (...)
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  48.  22
    Neutrosophic Approach to Grayscale Images Domain.A. A. Salama, Florentin Smarandache & Hewayda ElGhawalby - 2018 - Neutrosophic Sets and Systems 21:13-19.
    In this paper, we propose a new technique for the enhancing images. It will work on removing the noise contained in the image as well as improving its contrast based on three different enhancing transforms, we commence by embedding the image into a neutrosophic domain; where the image will be mapped in three different levels, a level of trueness, a level of falseness and a level of indeterminacy. Hence, we act separately on each level using the enhancement transforms. Finally, (...)
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  49.  12
    Thesaurus and Ontology Construction for Contra Dance: Knowledge Organization of a North American Folk Dance Domain.L. P. Coladangelo - 2021 - Knowledge Organization 47 (7):523-542.
    This case study aims to preserve and disseminate cultural heritage information about the North American community folk dance tradition of contra dance through development of a thesaurus of choreographic terms and a domain ontology. A survey of dance resources was conducted, reviewing historic and modern examples of contra dance choreography notation and instructions, records of dance events, and recordings of dance performances. Domain and content analysis were performed on the resources to collect and organize concepts and themes regarding (...)
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  50.  98
    The structure and function of spontaneous analogising in domain-based problem solving.Christopher R. Bearman, Linden J. Ball & Thomas C. Ormerod - 2007 - Thinking and Reasoning 13 (3):273 – 294.
    Laboratory-based studies of problem solving suggest that transfer of solution principles from an analogue to a target arises only minimally without the presence of directive hints. Recently, however, real-world studies indicate that experts frequently and spontaneously use analogies in domain-based problem solving. There is also some evidence that in certain circumstances domain novices can draw analogies designed to illustrate arguments. It is less clear, however, whether domain novices can invoke analogies in the sophisticated manner of experts to (...)
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