Departing from Pierre Bayle's discussion of Spinoza in the entry 'Japan' in his Dictionaire, this article discusses how debates about the Far East functioned as a foil for the polemics generated by the Radical Enlightement. The central point of investigation is a debate between Gerard Vossius and Georg Hornius, integrating three main issues where ideas about the East challenged accepted European authority: sacred history, republicanism, and natural philosophy. The article demonstrates that the onset of radicalism involved a plethora of old, (...) new and exotic ideas, from logic to linguistics and Hermeticism, before crystallizing into the scientific and political notions now associated with modernity. (shrink)

Gedurende 2017 herdenk Lutherse en Calvinistiese kerke die Kerkhervorming wat 500 jaar gelede plaasgevind het. Hierdie hoofstuk fokus op Johannes Calvyn se eerste publikasies, dit wil sê publikasies wat verskyn het voordat hy met sy bediening in Genève begin het. Die fokus val op die drie belangrikste publikasies in hierdie periode, te wete sy 'Kommentaar op Seneca se De Clementia', die 'De Psychopannychia' en die eerste uitgawe van sy 'Christianae Religionis Institutio'. In hierdie eerste drie publikasies is 'n jeugdige Calvyn (...) aan die woord. Ten spyte daarvan is die publikasies omvangryk en is dit duidelik dat Calvyn vroeg in sy lewe oor omvangryke kennis en insig beskik het. Die vroegste publikasies word somtyds as van minder belang geag. In hierdie bydrae word die stelling gemaak dat die publikasies van groot belang is omdat Calvyn talle van die gedagtes wat later in sy werke na vore kom, reeds in sy vroeë werke aan die orde gestel het. (shrink)

Amsterdam University Press is a leading publisher of academic books, journals and textbooks in the Humanities and Social Sciences. Our aim is to make current research available to scholars, students, innovators, and the general public. AUP stands for scholarly excellence, global presence, and engagement with the international academic community.

Rosenberg has rightly argued that fitness is supervenient. But he has wrongly assumed that this makes The fittest survive nontautologous. Supervenience makes strict reduction impossible. It sheds light on disputes concerning the testability of evolutionary theory.

Periodic attacks of uncertain origin, where the clinical presentationresembles epilepsy but there is no evidence of a somatic disease, arecalled Pseudo-Epilepsy or Pseudo-Epileptic Attack Disorder (PEAD). PEADmay be called a `non-disease', i.e. a disorder on the fringes ofestablished disease patterns, because it lacks a rationalpathophysiological explanation. The first aim of this article is tocriticize the idea, common in medical science, that diseases are realentities which exist separately from the patient, waiting to bediscovered by the doctor. We argue that doctor and (...) patient construct adisease, and that the construction of the disease PEAD includes manynormative evaluations. The second aim is to provide insight into thesuffering of patients with PEAD. We focus on three aspects of thepatient, identity, autonomy and responsibility. We present somecharacteristic descriptions of (pseudo-)epileptic attacks by FjodorDostoevsky, Gustave Flaubert and Thomas Mann. We argue that diagnosingPEAD reduces a meaningful life event into an insignificant, thoughintriguing, medical phenomenon, and that the patient will not benefitfrom being diagnosed as having PEAD. (shrink)

The participation of minors in clinical trials is essential to provide safe and effective medical care to children. Because few drugs have been tested in children, pediatricians are forced to prescribe medications off-label with uncertain efficacy and safety. In this article, we analyze how the enrollment of minors in clinical trials is negotiated within relationships of mutual trust between clinicians, minors, and their parents. After a brief description of the problems associated with involving minors in clinical research, we consider how (...) existing “relationships of trust” can be used as a place where the concerns of research subjects can be more fully discussed and addressed. Building on the tacit recognition of trust found in The European Clinical Trials Directive we make policy recommendations that allow for clearer, more ethically informed guidelines for enrolling minors in clinical research. (shrink)

This paper provides an early evaluation of Artificial Intelligence against COVID-19. The main areas where AI can contribute to the fight against COVID-19 are discussed. It is concluded that AI has not yet been impactful against COVID-19. Its use is hampered by a lack of data, and by too much data. Overcoming these constraints will require a careful balance between data privacy and public health, and rigorous human-AI interaction. It is unlikely that these will be addressed in time to be (...) of much help during the present pandemic. In the meantime, extensive gathering of diagnostic data on who is infectious will be essential to save lives, train AI, and limit economic damages. (shrink)

In order to contain public care expenditure, policymakers in the Netherlands have over the last decades formulated in ever more stringent ways what ought to be expected from spouses, partners, and family members with regard to care for dependent relatives. The current Dutch coalition cabinet plans to shift the principal responsibility for nonmedical care, including demanding forms of care such as long-term personal care, to individuals and families. I argue that these policy developments imply cost redistribution rather than cost containment (...) and that this redistribution is disadvantageous for women. (shrink)

Thinking out of habit: an embodied perspective In the second half of the twentieth century, habit had received little attention in the cognitive sciences and philosophy of cognition. This despite the extensive theoretical attention habit received in phenomenology and pragmatism. This is because due to influence of behaviorism and the cognitivist revolution, habit was reduced to mechanical stimulus-response reaction that is learned through drill and repetition, and therefore habit cannot be considered intelligent. In this article I argue that a richer (...) and more accurate notion of habit is possible through an embodied vision of cognition, namely enactivism and ecological psychology. This means that we can consider habit as intelligent without equating habit with reflective thought. Such a notion is possible because both enactivism and ecological psychology have their conceptual roots in pragmatism and phenomenology. Secondly, an embodied vison of cognition can describe how our habits are formed from sensorimotor contingencies and are self-organizing patterns of behavior in interaction with an environment. This can be described through the metaphor of ‘laying down a path’, whereby taking a shortcut across a field of grass a path is formed, which enables walking across the field of grass. Laying down a path is more than a metaphor, but also an example of the sociomaterial dimension of habit. Habits are always formed in an interaction between an organism and an environment that is, in our case both material and social. (shrink)

Coping with stress has been primarily investigated as an individual-level phenomenon. In work settings, however, an individual’s exposure to demands is often shared with co-workers, and the process of dealing with these demands takes place in the interaction with them. Coping, therefore, may be conceptualized as a multilevel construct. This paper introduces the team coping concept and shows that including coping as a higher-level team property may help explain individual-level outcomes. Specifically, we investigated the effects of exposure to danger during (...) deployment on burnout symptoms in military service members and examined to what extent this relationship was moderated by individual-level and team-level functional coping. We hypothesized that the relationship between individuals’ exposure to danger and burnout is contingent on both. In line with our predictions, we found that service members who were highly exposed to danger, and did not engage in much functional coping, suffered most from burnout symptoms, but only when their teammates did not engage in much functional coping either. When their teammates did engage in much functional coping, the effect of exposure to danger on burnout was buffered. Hence, team members’ coping efforts functioned as a resilience resource for these service members. (shrink)

The metaphor of base and superstructure has been one of the most controversial elements in Marxist aesthetics. In this text I discuss some of the many questions it raises. Today, many theorists believe that its problems are so extensive that it has lost all plausibility. I believe, however, that in rejecting the Marxist framework, aesthetics and cultural theory risks throwing out the baby with the bath water and jeopardizes its critical potential. Drawing on the work of Fredric Jameson and Slavoj (...) Žižek, I will propose a heuristic reinterpretation of the metaphor of base and superstructure. (shrink)

The impact of philosophy of science on biology is slight. Evolutionary biology, however, is nowadays an exception. The status of the neo-Darwinian (synthetic) theory of evolution is seriously challenged from a methodological perspective. However, the methodology used in the relevant discussions is plainly defective. A correct application of methodology to evolutionary theory leads to the following conclusions. (a) The theory of natural selection (the core of neo-Darwinism) is unfalsifiable in a strict sense of the term. This, however, does not militate (...) against the theory, because no scientific theory whatever is testable in this way. Under a more liberal testability criterion, the theory is surely testable. None the less, certain (not all) research programs may tend to make the theory untestable in practice. (b) It has often been argued that the tautologous character of the principle of natural selection, allegedly the focus of evolutionary theory, makes the theory untestable through circular reasoning. Actually, the principle is only a tautology if fitness is wrongly defined in terms of actual survival. But even then circular reasoning need not ensue. (c) Evolutionary principles do not permit, without additional information, the derivation of statements about evolutionary events concerning particular species or populations. If this were a reason to criticize the theory (as has been argued in the literature), any other scientific theory would be inadequate by the same token. (shrink)

The polymath Michel de Certeau is traditionally seen as one of a group of French poststructuralist thinkers who reject constructs in the social sciences in favor of the diversity of the everyday or the past. However, in this paper I will show that, as a historian, Certeau did not discard these constructs, but rather valued them as a means of doing justice to the “strangeness” of the past. The position that Certeau adopts can be seen most clearly from his theoretical (...) debate with Paul Veyne, which is the starting point of this article. I then show how Certeau’s first major historical work, The Possession at Loudun, exemplifies his theoretical position. An analysis of this work demonstrates how the historian’s active reconstruction of interactions between exorcists, medical doctors, state officers, and possessed nuns helps us to perceive the complexity of the past in a way that can be seen as a microhistory avant la lettre. I will suggest that during his writing of the history of Loudun, Certeau implicitly raises more theoretical and epistemological problems, and in so doing he “practices” a theory of history. The most elusive aspect of the story at Loudun turns out to be the drama around the priest Grandier. This article demonstrates how Certeau pays tribute to Grandier by using “scientific” methods, thus showing the “limits of representation” through disciplinary means. Finally, the article explores the implications of Certeau’s theory and practice of the writing of history for understanding historiography at large. The historian not only appears as a tramp who looks for remains that are forever lost to us, but is also a “scientist” who uses both models and concepts in order to put them to the test. (shrink)

BackgroundResearch misconduct and questionable research practices have been the subject of increasing attention in the past few years. But despite the rich body of research available, few empirical works also include the perspectives of non-researcher stakeholders.MethodsWe conducted semi-structured interviews and focus groups with policy makers, funders, institution leaders, editors or publishers, research integrity office members, research integrity community members, laboratory technicians, researchers, research students, and former-researchers who changed career to inquire on the topics of success, integrity, and responsibilities in science. (...) We used the Flemish biomedical landscape as a baseline to be able to grasp the views of interacting and complementary actors in a system setting.ResultsGiven the breadth of our results, we divided our findings in a two-paper series with the current paper focusing on the problems that affect the integrity and research culture. We first found that different actors have different perspectives on the problems that affect the integrity and culture of research. Problems were either linked to personalities and attitudes, or to the climates in which researchers operate. Elements that were described as essential for success were often thought to accentuate the problems of research climates by disrupting research culture and research integrity. Even though all participants agreed that current research climates need to be addressed, participants generally did not feel responsible nor capable of initiating change. Instead, respondents revealed a circle of blame and mistrust between actor groups.ConclusionsOur findings resonate with recent debates, and extrapolate a few action points which might help advance the discussion. First, the research integrity debate must revisit and tackle the way in which researchers are assessed. Second, approaches to promote better science need to address the impact that research climates have on research integrity and research culture rather than to capitalize on individual researchers’ compliance. Finally, inter-actor dialogues and shared decision making must be given priority to ensure that the perspectives of the full research system are captured. Understanding the relations and interdependency between these perspectives is key to be able to address the problems of science.Study registrationhttps://osf.io/33v3m. (shrink)

Developing research questions -- Developing the framework for an ethical assessment -- Possible legitimation of whistleblowing policies -- Screening whistleblowing policies -- Towards what legitimation of whistleblowing?

The paper is a contribution to intuitionistic reverse mathematics. We introduce a formal system called Basic Intuitionistic Mathematics BIM, and then search for statements that are, over BIM, equivalent to Brouwer’s Fan Theorem or to its positive denial, Kleene’s Alternative to the Fan Theorem. The Fan Theorem is true under the intended intuitionistic interpretation and Kleene’s Alternative is true in the model of BIM consisting of the Turing-computable functions. The task of finding equivalents of Kleene’s Alternative is, intuitionistically, a nontrivial (...) extension of the task of finding equivalents of the Fan Theorem, although there is a certain symmetry in the arguments that we shall try to make transparent. We introduce closed-and-separable subsets of Baire space $${\mathcal{N}}$$ and of the set $${\mathcal{R}}$$ of the real numbers. Such sets may be compact and also positively noncompact. The Fan Theorem is the statement that Cantor space $${\mathcal{C}}$$, or, equivalently, the unit interval [0, 1], is compact and Kleene’s Alternative is the statement that $${\mathcal{C}}$$, or, equivalently, [0, 1], is positively noncompact. The class of the compact closed-and-separable sets and also the class of the closed-and-separable sets that are positively noncompact are characterized in many different ways and a host of equivalents of both the Fan Theorem and Kleene’s Alternative is found. (shrink)

This year we celebrated Stuart Kauffman’s 80th birthday. Kauffman has contributed many original ideas to science. One of them is that of autocatalytic sets in the context of the origin of life. An autocatalytic set is a self-sustaining chemical reaction network in which all the molecules mutually catalyze each other’s formation from a basic food source. This notion is often seen as a “counterargument” against the dominant genetics-first view of the origin of life, focusing more on metabolism instead. The original (...) notion was introduced back in 1971, but it has taken several decades for this idea to really catch on. Thanks to theoretical as well as experimental progress in more recent research on autocatalytic sets, especially over the past 15 years, the idea now seems to be gaining significant interest and support. In this tribute to Kauffman’s work and ideas, a brief history of research on autocatalytic sets is presented. (shrink)

This article deals with the question of how self-organization in living organisms is realized. Self-organization may be observed in open systems that are out of equilibrium. Many disequilibria-conversion phenomena exist where free energy conversion occurs by spontaneously formed engines. However, how is self-organization realized in living entities? Living cells turn out to be self-organizing disequilibria-converting systems of a special kind. Disequilibrium conversion is realized in a typical way, through employing information specifying protein complexes acting as nano engines. The genetic code (...) enables processing of information—derived from coding DNA—to produce these molecular machines. Hence, information is at the core of living systems. Two promising approaches to explaining living cells containing sequences carrying information are mentioned. Also discussed is the question of whether a second concept of self-organization—namely, the Kantian concept—applies. (shrink)

Education in the post-truth era: Reflections on the role of learning in sustainability and democracy This paper revisits the field of (Higher) Education for Sustainable Development in a post-truth era. It reflects on the current debate regarding the role of education in sustainability from a Deweyan perspective. This approach leads towards a renewed interpretation of individual sustainability competences in societal context influenced by post-truth characteristics and super wicked problems. The Deweyan perspective with focus on personal flourishing and the role of (...) education in democracy, provides guiding principles to frame individual sustainability competences in the current post-truth context, thereby highlighting the importance of critical inquiry. The paper recommends to revisit the connection between education and sustainability from a personal and societal perspective, thereby taking into account the current context of higher education, influenced by neoliberalism, economic efficiency and managerialism. (shrink)

Amsterdam University Press is a leading publisher of academic books, journals and textbooks in the Humanities and Social Sciences. Our aim is to make current research available to scholars, students, innovators, and the general public. AUP stands for scholarly excellence, global presence, and engagement with the international academic community.

The ongoing COVID-19 pandemic and resulting health and economic crisis has caused major disruptions in the functioning of food systems and revived the discussion on what forms balanced, effective and responsible crisis management. As part of its thought leadership and its social responsibility in times of crisis, WUR is uniquely placed to contribute to the scientific knowledge base and data collection mechanisms required for early recognition and rapid response. In addition, WUR takes on the challenge to generate timely insights into (...) the possible scenarios for the prevention of a crisis and during and after emergencies to enable our clients and stakeholders to make informed decisions. Lastly, WUR can provide a better understanding of the mechanisms of spillover, and tangible and practical tools to help reduce the risk of spillover events from occurring, prevent pathogen spread, or mitigate the impacts of a future pandemic. In its research institutes and university, WUR brings together expertise in human, animal, plant and environmental health, the global agri-food system, economics, social sciences, food safety and security, ethics, and policy. Here, in the knowledge that COVID-19 will not be the last pandemic, we present WUR’s ambition and capabilities towards an integrated global multi-stakeholder approach to the prevention and management of potentially pandemic diseases, across the four phases of crisis management; prevention, preparedness, response, and recovery and learning. (shrink)

This article is about the logic of the concept of "coherence" as used by historians to justify an argument. Despite its effectiveness in historical arguments, coherence is problematic for epistemologists and some theorists of history. The main purpose of this paper is to present some insights that bear upon the logical status of coherence. As will be demonstrated, this will also shed some light on the allegedly dubious epistemological position of coherence. In general I will argue that, logically seen, coherence (...) is a property of a set of related beliefs which makes it possible to justify a choice out of different factually justifiable interpretations. Coherence disambiguates vague or ambiguous observations. As words lose their vagueness or ambiguity in contexts, so do contexts disambiguate historical facts. My argument will be based on some relatively recent findings about the cognitive processes underlying vision and reading. Research in the field of text linguistics is used to show what kinds of relationship exist between historical representations that might be considered to cohere. (shrink)