The emphasis in human pluripotent stem cell (hPSC) technologies has shifted from cell therapy to in vitro disease modelling and drug screening. This review examines why this shift has occurred, and how current technological limitations might be overcome to fully realise the potential of hPSCs. Details are provided for all disease‐specific human induced pluripotent stem cell lines spanning a dozen dysfunctional organ systems. Phenotype and pharmacology have been examined in only 17 of 63 lines, primarily those that model neurological and (...) cardiac conditions. Drug screening is most advanced in hPSC‐cardiomyocytes. Responses for almost 60 agents include examples of how careful tests in hPSC‐cardiomyocytes have improved on existing in vitro assays, and how these cells have been integrated into high throughput imaging and electrophysiology industrial platforms. Such successes will provide an incentive to overcome bottlenecks in hPSC technology such as improving cell maturity and industrial scalability whilst reducing cost. (shrink)

We investigate the effectiveness of corporate social responsibility disclosure in protecting corporate reputation following financial restatements. As expected under legitimacy theory, firms can signal their legitimacy via nonfinancial disclosure after the negative effects of financial restatements. Our results show that restating firms make substantial improvements to overall CSR disclosure quality by changing their standalone reports to a more conservative tone, increasing readability and report length, even though they strategically disclose less forward-looking and sustainability-related content. Such improvements are more pronounced in (...) restating firms with prior low-quality CSR disclosure. Moreover, restating firms with CSR disclosure have smaller forecast errors than non-CSR disclosers, yet the change in CSR disclosure after restatements does not further improve analyst forecast accuracy. Finally, we find that compared with nondisclosers, restating firms with CSR disclosure suffer smaller firm value losses. Overall, the evidence supports the view that consistent CSR reporting alleviates reputational damage and plays an insurance-like or value protection role during crisis periods. (shrink)

RECENT PHILOSOPHICAL ATTENTION TO THE LANGUAGE OF DISEASE HAS FOCUSED PRIMARILY ON THE QUESTION OF ITS VALUE-NEUTRALITY OR NON-NEUTRALITY. PROPONENTS OF THE VALUE-NEUTRALITY THESIS SYMBOLICALLY COMBINE POLITICAL AND OTHER CRITICISMS OF MEDICINE IN AN ATTACK ON WHAT THEY SEE AS VALUE-INFECTED USES OF DISEASE LANGUAGE. THE PRESENT ESSAY ARGUES AGAINST TWO THESES ASSOCIATED WITH THIS VIEW: A METHODOLOGICAL THESIS WHICH TENDS TO DIVORCE THE ANALYSIS OF DISEASE LANGUAGE FROM THE CONTEXT OF THE PRACTICE OF MEDICINE AND A SUBSTANTIVE THESIS WHICH (...) HOLDS THAT DISEASE LANGUAGE IS EVALUATIVELY NEUTRAL. IN PARTICULAR, THE ESSAY CRITICALLY FOCUSES ON THE VALUE NEUTRAL POSITION ADOPTED BY CHRISTOPHER BOORSE, WHICH HE TERMS A FUNCTIONAL THEORY OF DISEASE. THE ARGUMENT CONCERNS WHETHER OR NOT ONE CAN HAVE VALUE NEUTRAL DESCRIPTION OF DISEASE STATES OR WHETHER DISEASE LANGUAGE ESSENTIALLY INVOLVES VALUES. (shrink)

"Those who think they know George Dickie's views should be sure to read this book. They are in for some interesting surprises. Of course, those unfamiliar with Dickie's views will also learn a lot." --Anita Silvers, San Francisco State University In this book George Dickie presents a theory about how to judge a work of art--as opposed to a theory that explains why a particular work is defined as art. Focusing mainly on the writings of Monroe Beardsley and (...) critically examining the views of seven other philosophers and art critics--Paul Ziff, Frank Sibley, Nelson Goodman, Nicholas Wolterstorff, David Hume, Bruce Vermazen, and J. O. Urmson--Dickie synthesizes their insights to discover what can be derived from their theories. On this basis, he attempts to work out a theory of art evaluation--the first such book on this topic by a contemporary philosopher. Initially, the author outlines all possible theories of art evaluation, assuming that traditional evaluative notions are used. He identifies seven theory-types that fall under four general headings: imitation value theory, objective intrinsic value theories, subjective intrinsic value theory, and instrumental value theories. Dickie then discusses the historical development of the theory of art evaluation, examining the ways in which eighteenth- and nineteenth-century philosophers treated representation and other cognitive dimensions of art as artistic values. His thorough analysis of the work of other contemporary theorists argues for a theory of art evaluation derived from various strands of thought. (shrink)

With this issue George Annas contributes his last At Law to the Hastings Center Report. Since the column was inaugurated in 1976 as Law and the Life Sciences, George has charted the course of biomedical ethics in the courts, challenging readers to come to grips with an emerging body of law in provocative analyses of critical decisions. As he retires from this column we wish him well, and look forward to his continued contributions to our pages. In bidding (...) farewell to one friend we are nonetheless pleased to welcome another as Alexander Morgan Capron, Henry W. Bruce University Professor of Law and Medicine at the University of Southern California and codirector of the Pacific Center for Health Policy and Ethics, joins the Report in the September‐October issue as a regular contributor to this column. Prof. Capron, formerly executive director of The President's Commission for the Study of Ethical Problems in Medicine and Biomedical and Behavioral Research, is a distinguished scholar and writer well known to our readers. We welcome the opportunity to share his insights on issues before courts and legislatures nationwide. (shrink)

Compensation for research related injuries is a subject that is increasingly gaining traction in developing countries which are burgeoning destinations of multi center research. However, the existence of disparate compensation rules violates the ethical principle of fairness. The current paper presents a comparison of the policies of Brazil, Russia, India, China and South Africa. A systematic search of good clinical practice guidelines was conducted employing search strategies modeled in line with the recommendations of ADPTE Collaboration. The search focused on three (...) main areas namely bibliographic data bases, clinical practice guidelines data bases and a restricted internet search. A manual search of references cited in relevant guideline documents was also conducted. The search terms, Medical Subject Headings and key words were developed for a PubMed platform and then adapted for all other data bases. The search terms were kept constant for each country with the only difference being the country name. The documents so obtained were subjected to systematic content analysis. The study revealed that there is vast panoply of regulations which exist on a continuum. On one extreme is India with comprehensive regulations that are codified into law, and on the other end there is China which does not have specific laws regulating research related injuries. There are a number of differences and similarities such as mandatory insurance requirements, existence of no fault compensation, compensable injuries and the role of research ethics committees. It is imperative to enact legislations that protect participants without stifling the research enterprise. There is need for consistency and ideally harmonization of such regulations at a global level. A model policy on compensation for research related injuries should borrow from the best aspects of the different country policies and should be informed by the cardinal ethics principles of autonomy, justice and beneficence. (shrink)

This chapter gives a broad description of the nature of properties and explains the foundations of metaphysics. It provides general statements about properties and how they describe parts of a metaphysical environment. These properties are used to develop the theory of causal powers. The chapter also attempts to address the ‘rights’ and ‘wrongs’ of nominalism and realism, including selective realism and its properties. The chapter also introduces conceptual distinctions such as derivative-basic, first-order-higher-order, simple-complex, essential-necessary-accidental, extrinsic-intrinsic, and transferable-non-transferrable. Secondary definitions are (...) also given. (shrink)

Me, You, Us addresses a range of issues in moral and political philosophy and moral psychology, but are unified by their starkly individualistic view of the moral subject. They challenge recent tendencies to conceptualize normative issues in terms of relationships, collectivities, and social meanings.

This chapter contains sections titled: Introduction An Analysis of the Problem What is Deliberative Democracy? Civil Society and Deliberative Politics The African State and Deliberative Democracy.

Volume 20, Issue 7, July 2020, Page 167-169.

First Published in 1999. Routledge is an imprint of Taylor & Francis, an informa company.

Volume 19, Issue 6, June 2019, Page 1-3.

In lieu of an abstract, here is a brief excerpt of the content:HUME'S DIALOGUES AND THE REDEFINITION OF THE PHILOSOPHY OF RELIGION GEORGE ScHNER, S.J. Regis College Toronto, Ontario HETHER ONE IS rethinking the content of a course and the place of one's study in the context of a broader curriculum, or whether there is a moment of fundamental questioning which grows out of rereading a classic text or engaging in contemporary debates, such moments of questioning are essential. This (...) essay proposes one of those simple and general questions: in what does the work of the philosophy of religion consist? My consideration of the question, as will become evident, is an exercise in prolegomena, and after this brief introduction there will be two parts to my essay in which the context for a full answer to the question will be explored, before a summary conc1usion will propose an agenda for ful1ther work. Though concept clarification is essential to philosophical reflection, attention to historical development is of equal importance. The two inner parts of this essay will give attention to both, first by discussing a specific texrt and,author, and then by sorting out some fundamental matters of definition. My choice of a classic text and context is David Hume's Dialogues Concerning Natural Religion.1 Such a choice is not to imply that the philosophy of religion begins there or that Hume's notion of either philosophy or religion is: somehow normative. On the contrary, I am entering rthe story in mid1 Dialogues Oonoerning Naturai Religion, ed. R. H. Popkin (Cambridge: Hackett Publishing Co., 1980). References will be indicated within the text by page number. 88 84 GEORGE SCHNER, S.j. stream and am not of the mind that any philosophy is definitive. However, I wish to propose a reading of Hume's text which can be very helpful not only to understand what he is about but also to encourage a rethinking of what the philosophy of religion should be about. Simply as a text, Hume's Dialogues is intriguing. He withheld its publication on the advice of seveml of his friends and continued to revise it until his death, altering nearly every page styJistica1ly and substantively changing all hut four sections. :Before he died, he ensured that his nephew David would have the work published and was busy with some of the most lengthy additions to the text in the last months before his death.2 The work and its contents dearly remained a matter of importance and preoccupation for Hurne, and both the contents and form of the text present essentials of Hume's mature thought. The apparent meandering of the text, as a dialogue among the characters Cleanthes, Philo, and Demea, belies its careful construction. Despite Cleanthes' accusation that Philo proposes his notions in a " rambling way," the logic of the text is a masterpiece of exposition, movement, internal reference, and cumulative rhetorical effect. David Livingston has recently discussed the dialect~cal and narrative character of Hume's writing considered in general as a philosophy of "common life." 3 Hume is seen as both the critic of false philosophy and the artificer of the true by means of the application of his principles of the association of ideas, of nrutural beliefs, of sympathy. In both efforts, Livingston finds Hume increasingly employing narrative aocounts and dialectical argument as he develops his,thought, until in the Dialogues "inquiry is cut free of all systematic constraints and allowed to proceed on its own." 4 I find the insight into Hume's paradigmatic use of 2 These and other details concerning the Dialogues can be found in Ernest C. Mossner, The Life of David Hume (Oxford: Clarendon Press, 1980). s D. W. Livingston, Hume's Philosophy of Comm01~ Life (Chicago: University of Chicago Press, 1984), esp. chapter two. 4 Livingston, 43. HUME.AND PHILOSOPHY OF RELIGION 85 the narrative structure of historical inquiry a helpful clue, but I wouJd modify Livingston's assertion of the abandonment of systematic constraints in the Dialogues. Hume's corrective of speculative systems does not mean that his own text is devoid of a logic or ol'der quite in keeping with the demands of narrative structure, common life, and the past-entailing aspects... (shrink)

Based on the ideas of Einstein and Minkowski, this concise treatment is derived from the author's many years of teaching the mathematics of relativity at the University of Michigan. Geared toward advanced undergraduates and graduate students of physics, the text covers old physics, new geometry, special relativity, curved space, and general relativity. Beginning with a discussion of the inverse square law in terms of simple calculus, the treatment gradually introduces increasingly complicated situations and more sophisticated mathematical tools. Changes in fundamental (...) concepts, which characterize relativity theory, and the refinements of mathematical technique are incorporated as necessary. The presentation thus offers an easier approach without sacrifice of rigor. Dover (2014) republication of the edition published by John Wiley & Sons, New York, 1950. See every Dover book in print at www.doverpublications.com. (shrink)

A notion that was prevalent throughout the twentieth century and persists into the present, is that Bonaventure compiled the Legenda maior as a means to make peace between two quarreling factions within the Franciscan order—the Spirituals and the Conventuals.2 Some have suggested a twofold function: "restoration of peace and harmony within the order" and the "[vindication of] the friars in the eyes of the world."3 Others prefer to regard the political implications of the Legenda as incidental, focusing instead on the (...) ways in which it succeeds in capturing the general nature of Franciscan spirituality.4 This article aims to contribute to this conversation by investigating... (shrink)

Volume 51, Issue 14, December 2019, Page 1408-1412.

Intuitive theology.--The theology of the Hebrews.--Christian theology.--Christian belief.