Modern theories of authoritarianism have stressed the importance of threat to the expression of authoritarian attitudes and intolerance. Arguably, authoritarian tendencies may have increased during COVID-19 pandemic, a major threat to life and security. One issue arising when comparing mean scores is that of measurement invariance. Meaningful comparisons are only possible, if latent constructs are similar between groups and/or across time. This prerequisite is rarely ever tested in research on authoritarianism. In this study, we aim to analyze the short scale (...) for authoritarianism KSA-3 by investigating its measurement invariance on two levels and latent mean changes using two German representative samples. Specifically, we look at differences before and during the pandemic. While measurement invariance holds across both levels in all conditions, we find a decrease in latent means in 2020, contrary to expectations and established theories. Moreover, latent means differ with regard to gender, education, and east–west Germany. We conclude that analyses of latent means and measurement invariance instead of mean comparisons with composites should become the standard. Future studies should focus on threat as a moderator between authoritarianism and intolerance, and on possible interactions with context variables. (shrink)

The occurrence of the novel severe acute respiratory syndrome coronavirus-2 at the end of 2019 comes along with many challenges. Besides worry for one’s own health and the well-being of the family, all measures applied to limit the spread of the coronavirus affected daily life. School closures, economic shutdown and contact restrictions have led to high levels of stress. The impact on health and families has been widely discussed. However, population-based data are scarce. Here, we have assessed health, quality of (...) life and intrafamilial relations depending on the COVID-19 pandemic. Using a three-step random-route approach, a population-based sample of 2,515 persons was recruited during the second COVID-19 wave in Germany in winter 2020/21. While the majority of participants reported no change in their health status and the relationship with their partner and children, more than half of participants reported a decreased quality of life since the beginning of the pandemic. Female gender, age above 60 years, a low household income, not living with a partner and the experience of childhood adversity were associated with a higher risk for a worsening of health, quality of life and intrafamilial relations. These had already been well-established risk factors ahead of the pandemic. In order to avoid further increase of inequality in our society and more devastating impact of the pandemic on health and intrafamilial relations, low-level support and intervention programs are urgently needed. (shrink)

The monitoring role performed by the board of directors is an important corporate governance control mechanism, especially in countries where external mechanisms are less well developed. The gender composition of the board can affect the quality of this monitoring role and thus the financial performance of the firm. This is part of the “business case” for female participation on boards, though arguments may also be framed in terms of ethical considerations. While the issue of board gender diversity has attracted growing (...) research interest in recent years, most empirical results are based on U.S. data. This article adds to a growing number of non-U.S. studies by investigating the link between the gender diversity of the board and firm financial performance in Spain, a country which historically has had minimal female participation in the workforce, but which has now introduced legislation to improve equality of opportunities. We investigate the topic using panel data analysis and find that gender diversity – as measured by the percentage of women on the board and by the Blau and Shannon indices – has a positive effect on firm value and that the opposite causal relationship is not significant. Our study suggests that investors in Spain do not penalise firms which increase their female board membership and that greater gender diversity may generate economic gains. (shrink)

The aim of this Swedish study was to develop the concept of moral sensitivity in health care practice. This process began with an overview of relevant theories and perspectives on ethics with a focus on moral sensitivity and related concepts, in order to generate a theoretical framework. The second step was to construct a questionnaire based on this framework by generating a list of items from the theoretical framework. Nine items were finally selected as most appropriate and consistent with the (...) research team’s understanding of the concept of moral sensitivity. The items were worded as assumptions related to patient care. The questionnaire was distributed to two groups of health care personnel on two separate occasions and a total of 278 completed questionnaires were returned. A factor analysis identified three factors: sense of moral burden, moral strength and moral responsibility. These seem to be conceptually interrelated yet indicate that moral sensitivity may involve more dimensions than simply a cognitive capacity, particularly, feelings, sentiments, moral knowledge and skills. (shrink)

A key challenge for probabilistic causal models is to distinguish non-causal probabilistic dependencies from true causal relations. To accomplish this task, causal models are usually required to satisfy several constraints. Two prominent constraints are the causal Markov condition and the faithfulness condition. However, other constraints are also needed. One of these additional constraints is the causal sufficiency condition, which states that models must not omit any direct common causes of the variables they contain. In this paper, I argue that the (...) causal sufficiency condition is problematic: (1) it is incompatible with the requirement that the variables in a model must not stand in non-causal necessary dependence relations, such as mathematical or conceptual relations, or relations described in terms of supervenience or grounding, (2) it presupposes more causal knowledge as primitive than is actually needed to create adequate causal models, and (3) if models are only required to be causally sufficient, they cannot deal with cases where variables are probabilistically related by accident, such as Sober’s example of the relationship between bread prices in England and the sea level in Venice. I show that these problems can be avoided if causal models are required to be monotonic in the following sense: the causal relations occurring in a model M would not disappear if further variables were added to M. I give a definition of this monotonicity condition and conclude that causal models should be required to be monotonic rather than causally sufficient. (shrink)

The aim of this paper is to provide a systematic account of the metaphysically important distinction between haecceitistic properties, such as being David Lewis or being acquainted with David Lewis, and qualitative properties, such as being red or being acquainted with a famous philosopher. I first argue that this distinction is hyperintensional, that is, that cointensional properties can differ in whether they are qualitative. Then I develop an analysis of the qualitative/haecceitistic distinction according to which haecceitistic properties are relational in (...) a certain sense. I argue that this analysis can capture the hyperintensionality of the qualitative/haecceitistic distinction and is generally in accordance with the use of the notion of a qualitative property in philosophical debates. (shrink)

Let κ < λ be regular uncountable cardinals. Using a finite support iteration (in fact a matrix iteration) of ccc posets we obtain the consistency of b = a = κ < s = λ. If μ is a measurable cardinal and μ < κ < λ, then using similar techniques we obtain the consistency of b = κ < a = s = λ.

The goal of this paper is to argue that there is indeterminacy in causation. I present three types of cases in which it is indeterminate whether an event c caused another event e: (1) cases of absence causation recently discussed by Bernstein and by Swanson, (2) cases leading to Sorites paradoxes for causation, and (3) cases where c and e occur in certain indeterministic causal structures and it is therefore indeterminate whether there is a causal relation between them. These cases, (...) I argue, provide strong evidence that indeterminacy is an important general feature of the causal relation and that philosophical theorizing about causation should take this observation into account. (shrink)

Theories of graded causation attract growing attention in the philosophical debate on causation. An important field of application is the controversial relationship between causation and moral responsibility. However, it is still unclear how exactly the notion of graded causation should be understood in the context of moral responsibility. One question is whether we should endorse a proportionality principle, according to which the degree of an agent’s moral responsibility is proportionate to their degree of causal contribution. A second question is whether (...) a theory of graded causation should measure closeness to necessity or closeness to sufficiency. In this paper, we argue that we should indeed endorse a proportionality principle and that this principle supports a notion of graded causation relying on closeness to sufficiency rather than closeness to necessity. Furthermore, we argue that this insight helps to provide a plausible analysis of the so-called ‘Moral Difference Puzzle’ recently described by Bernstein. (shrink)

Let an X/Y distinction be a distinction between kinds of properties, such as the distinctions between qualitative and non-qualitative, intrinsic and extrinsic, perfectly natural and less-than-perfectly natural or dispositional and categorical properties. An X/Y distinction is hyperintensional iff there are cointensional properties P and Q, such that P is an X-property, whereas Q is a Y-property. Many accounts of metaphysical distinctions among properties presuppose that such distinctions are non-hyperintensional. In this paper, I call this presupposition into question. I develop a (...) sufficient condition for the hyperintensionality of X/Y distinctions and argue that this condition is satisfied by a number of standard classifications of properties. It follows that non-hyperintensional analyses of distinctions among properties are harder to defend than is often assumed. (shrink)

We investigate maximal free sequences in the Boolean algebra \ {/}\text {fin}\), as defined by Monk :593–610, 2011). We provide some information on the general structure of these objects and we are particularly interested in the minimal cardinality of a free sequence, a cardinal characteristic of the continuum denoted \. Answering a question of Monk, we demonstrate the consistency of \. In fact, this consistency is demonstrated in the model of Shelah for \ :433–443, 1992). Our paper provides a streamlined (...) and mostly self contained presentation of this construction. (shrink)

Epigenetic and transcriptional variability contribute to the vast diversity of cellular and organismal phenotypes and are key in human health and disease. In this review, we describe different types, sources, and determinants of epigenetic and transcriptional variability, enabling cells and organisms to adapt and evolve to a changing environment. We highlight the latest research and hypotheses on how chromatin structure and the epigenome influence gene expression variability. Further, we provide an overview of challenges in the analysis of biological variability. An (...) improved understanding of the molecular mechanisms underlying epigenetic and transcriptional variability, at both the intra- and inter-individual level, provides great opportunity for disease prevention, better therapeutic approaches, and personalized medicine. Epigenetic and transcriptional variability mediate phenotypic plasticity, enabling adaptation to changing environments. In this review, we describe the sources of inter- and intra-individual variability and discuss epigenetic regulators of gene expression variability, including DNA methylation and chromatin structure. Understanding these molecular mechanisms will improve therapeutic approaches and personalized medicine. (shrink)

Whether mental properties are identical with neural properties is one of the central questions of contemporary philosophy of mind. Many philosophers agree that even if mental properties are identical with neural properties, the mind-brain identity thesis cannot be established on empirical grounds, but only be vindicated by theoretical philosophical considerations. In his paper ‘When Is a Brain Like the Planet?’, Clark Glymour proposes a causal criterion for local property identifications and claims that this criterion can be used to empirically establish (...) local identities between mental and neural properties. If successful, such an account would settle the debate on the mind-body problem. In this paper, I argue that Glymour’s approach falls short of its aims. The causal criterion which he proposes does not provide a sufficient condition for the local identification of properties. Moreover, his account does not succeed in rendering local mind-brain identities empirically testable. Therefore, the mind-body problem cannot be solved as easily as Glymour assumes. (shrink)

Consumers have shown increasing interest in products that reflect social and environmental concerns—so-called “sustainable products.” Although consumers typically view sustainability positively, the ethical attributes of products do not always drive their preferences, which implies a trade-off between ethical attributes and other valued attributes. In the current research, we examine how consumers implicitly judge products and services that are more or less congruent with social and environmental concerns and how incongruity between ethical claims and a product’s nature may influence consumers to (...) behave responsibly. The results from two experimental studies show that increasing the strength of ethical claims impairs sophisticated products’ evaluation but enhances simple products’ evaluation. Additionally, the findings reveal that the strength of ethicality on sophisticated products may impair perceptions of product enjoyment to a point at which products are evaluated more favorably when less-ethical claims are used to promote them. For managers, the results highlight an important business consideration, as they reveal the circumstances under which it is worth emphasizing the strength of the sustainability appeal of products or services. Results show that not all consumers are willing to sacrifice taste or quality in their leisure time preferring to seize the day rather than saving the world. (shrink)

The development of sustainable agri-food systems requires not only new academic knowledge, but also concrete social and organizational change in practice. This article reflects on the action research process that supported and explored the learning process in an emerging agri-food value chain in the Berlin-Brandenburg region in eastern Germany. The action research study involved value chain actors, academic researchers, and process facilitators in a learning network. By framing the network’s learning and problem solving processes in concepts of organizational learning, lessons (...) were drawn for researchers and value chain developers. The results underline the importance of process facilitation in a learning value chain to create a social space, in which the actors in the value chain can interact and find a common basis for collaboration. In the learning process, facilitators used an iterative design to consistently align learning activities with the needs of practitioners to ensure practical relevance. To establish new practices and partnerships, value chain actors challenged existing routines and developed new ideas and visions, while at the same time improving established practices within their organizations and along the entire value chain. (shrink)

The proper way in which limit-problems [_Grenzprobleme_]—birth, death, dreamless sleep, the “prior to birth” [_das vor der Geburt_], the “after death” [_das nach dem Tod_], etc.—can be accessed according to Husserl is by means of so-called “construction” [_Konstruktion_] or “reconstruction” [_Rekonstruktion_]. Contrary to what is usually claimed with respect to this method, and therefore the acts it is composed of, this paper will attempt to prove that they do not consist in non-intuitive acts, but rather in intuitive, but non-sensible acts. (...) In other words, the aforementioned acts of construction consist in categorial acts. More specifically, they represent acts akin to the ones involved in the constitution of exact material essences of a qualitative (the “pure” red, the “pure” blue …) or of a geometrical kind (a triangle, a chiliagon …): both the acts involved in the constitution of elementary exact essences, or acts of idealization, and the acts involved in the constitution of derived exact essences, or acts of deriving. However, the acceptance of such acts of construction suggests a serious reconsideration of some of the basic tenets of Husserlian phenomenology. Indeed, it challenges the idea that phenomenology is an eidetic science of inexact—morphological, descriptive …—material essences, namely the essence of a subjective sphere (the essence of consciousness, the essence of ego …); in fact, it turns phenomenology, at least partially, into something Husserl explicitly repudiates on multiple occasions: a “geometry” of lived experience. It is thus important to determine whether these acts of construction should be integrated into Husserlian phenomenology, and, if yes, how they should be integrated into it. Providing an indication of this will be the ultimate goal of this paper. (shrink)

In diesem Buch stellt sich die Frage nach der Wahrheit nicht über den Gegensatz von wahr und falsch, sondern im Zusammenhang mit verschiedenen Modi der Gewißheit: Wahrheit in ihren komplexen Beziehungen zu praktischen Fragen und der Notwendigkeit von Urteilen. Diese Fragen werden systematisch differenziert und historisch diskutiert. Die Autorin verdeutlicht mit dem Nachweis der entscheidenden Funktion der Urteilskraft die Verbindungen und Bruchstellen zwischen theoretischer und praktischer Philosophie. Der Urteilskraft kommt als einer individuellen Fähigkeit die Aufgabe zu, die Reaktion Anderer auf (...) das eigene Fürwahrhalten ohne eine letzte allgemeine Regel einzuschätzen. Theoretische Philosophie geht hier in politische Philosophie (Kant) bzw. in Philosophie der Psychologie (Wittgenstein) über. (shrink)

This article examines the role of social media and journalistic media in presidential electoral processes. A systematic review of scientific articles published from 2012 to 2022 was conducted. The results indicate that the media has a significant influence on public perception and the political agenda during election campaigns. Furthermore, the importance of evaluating political leaders in the voters' decision-making process is emphasized. In summary, the article provides valuable insights into how the media can shape the narrative and public opinion during (...) presidential elections. (shrink)

The subject of this study is the participants in artificial sociality (humans and artificial intelligence (AI) tools) and communication between them. The first section analyses (using Luhmann’s methodology) communication as the basis of sociality. The second section shows how AI tools became social technologies in the framework of artificial sociality. The third section describes experimental communication between authors and AI tools (the case of ChatGPT). For the first time in the Baltic countries, the authors examined sociological, humanitarian, natural and technological (...) aspects of the functioning AI tools, which participate in creation of a new social reality for human society – artificial sociality. (shrink)

Mathematics educators suggest that students of all ages need to participate in productive forms of mathematical argument (NCTM, 2000). Accordingly, we developed two complementary frameworks for analyzing the emergence of mathematical argumentation in one second‐grade classroom. Children attempted to resolve contesting claims about the “space covered” by three different‐looking rectangles of equal area measure. Our first analysis renders the topology of the semantic structure of the classroom conversation as a directed graph. The graph affords clear “at a glance” visualization of (...) how various senses of mathematics—as imagined, as performed, and as historically rooted—were interrelated. The graph represents the emergence and intercoordination between conceptual and procedural knowledge in the ebb and flow of classroom conversation. The graph has not just descriptive, but also predictive power: Interconnectedness among the nodes of the graph representing the first 40 min of conversation predicted the structure of recall in the final ten minutes by children who had played little overt role in the conversation up to that point. The second, complementary framework draws upon Goffman's expanded repertoire of roles in speech to demonstrate how the teacher orchestrated this classroom conversation to establish coherent argument. In this second analysis, we establish how the teacher mediated between the everyday talk of her students and the discourse of mathematics. Her revoicing of student talk created interstices for identity and participation in the formation of the argument. Together, the two forms of analysis illuminate the emergence of mathematical argument at two levels: as collective structure and concurrently, as individual activity. (shrink)

Educational transitions play a pivotal role in shaping educational careers, and ultimately social inequality. Whereas parental socioeconomic status (SES) and cognitive ability have long been identified as key determinants of successful educational transitions, much less is known about the role of socio-emotional skills. To address this gap, the present study investigated whether Big Five personality traits predict success in the transition from secondary school to vocational education and training (VET) above and beyond SES, cognitive ability, and other covariates. Using data (...) from Starting Cohort 4 of the German National Educational Panel Study (NEPS; N = 4,137), we defined seven indicators of successful transition: obtaining a VET position, number of acceptances for VET positions, starting a VET position, (the absence of) dropout intentions and actual dropout, final VET grade, and satisfaction with VET. The results revealed that some Big Five traits were incrementally associated with several indicators of transition success. Conscientiousness emerged as the single most relevant trait, predicting all the transition success indicators but one (dropout intentions). The other Big Five traits had much weaker and less consistent links with transition success. Extraversion predicted the final VET grade and obtaining a VET position; Agreeableness was linked to a higher risk of dropout. Openness and Emotional Stability had no incremental effects on transition success. There was also some evidence for both compensatory and synergistic interactive effects, with Openness moderating mainly the effects of parental SES (on dropout intentions, actual dropout, and number of acceptances), and Agreeableness moderating the effects of cognitive ability (on obtaining a VET position, number of acceptances, and satisfaction with VET). Although individual effect sizes were small, the Big Five’s joint contribution to transition success was non-negligible, and often larger than that of sociodemographic characteristics and cognitive ability. Our results suggest a hitherto underappreciated contribution of personality to successful transitions to VET. (shrink)

El presente trabajo se propone indagar la posibilidad de la enseñanza de la ética desde la perspectiva de la construcción narrativa de sí mismo propuesta por Paul Ricoeur. En un primer momento se examinan las relaciones entre las nociones de identidad, relato y ética como práctica reflexiva. Luego, el trabajo sugiere la puesta en práctica de una propuesta de enseñanza que tenga en cuenta los relatos de ficción como mediadores necesarios para la reflexión ética, en tanto que las experiencias de (...) pensamiento realizadas en el plano ficcional son, en términos de Ricoeur, exploraciones hechas en el reino del bien y del mal. (shrink)

O artigo apresenta as lutas dos trabalhadores rurais boias frias no Brasil, valorizando sua riqueza e protagonismo em momentos históricos em que elas eram invisibilizadas tanto pela ditadura como por visões pré-concebidas de quem seriam os sujeitos das lutas por reforma agrária. O universo empírico da pesquisa é a região de Ribeirão Preto e Araraquara, no estado de São Paulo, representativa das contradições entre uma agricultura produtivista e a proletarização de um amplo contingente de trabalhadores. A partir deste contexto, propõe-se (...) uma metodologia centrada nas especificidades das lutas, não deduzidas das condições objetivas, mas marcada pelas experiências vividas pelos trabalhadores e pela identificação de seus interesses. (shrink)

Jeffery et al. extensively and thoroughly describe how different species navigate through a three-dimensional environment. Undeniably, the world offers numerous three-dimensional opportunities. However, we argue that for most navigation tasks a two-dimensional representation is nevertheless sufficient, as physical conditions and limitations such as gravity, thermoclines, or layers of earth encountered in a specific situation provide the very elevation data the navigating individual needs.

By virtually dominating French intellectual life (literature, philosophy, culture) during the early post-World War II period, Jean-Paul Sartre (1905–1980) embodied what Pierre Bourdieu calls a “total intellectual” – one who responds to and helps frame public debate on all the intellectual and political issues of the day. During his lifetime and even after his death in 1980, Sartre’s thinking and political engagements provoked sharp reactions, both positive and negative, in France and abroad. Marxism, decolonization struggles, and violence are three key (...) themes on which Sartre’s public positions continue to generate considerable debate – a debate that remains relevant today. (shrink)

Clinical and laboratory studies have demonstrated that executing a demanding dual-task while recollecting emotional memories weakens the emotional intensity and vividness of these memories. While t...

Two letters from William Burnside have recently been found in the Nachlass of Robert Fricke that contain instances of the Burnside Problem prior to its first publication. We present these letters as a whole to the public for the first time. We draw a picture of these two mathematicians and describe their activities leading to their correspondence. We thus gain an insight into their respective motivations, reactions, and attitudes, which may sharpen the current understanding of professional and social interactions of (...) the mathematical community at the turn of the twentieth century. (shrink)

“Sacra à Deo in corde discenda, natura ex natura.” Johann Christian Senckenberg's Observationes as a Medico-Theological Writing Method. In his early diaries, the pietist physician Johann Christian Senckenberg has taken down large amounts of observation data which mostly concentrated on his own body and soul. Earlier research has mistaken his diligent self-observation for hypochondria and unworldliness, especially since the author had never endeavoured to analyze and publish his work. The article shows that both his writing practice and his reluctance to (...) process and share its results are due to his deeply religious and firmly anti-rationalist conviction. The main purpose of his journal keeping was the attainment of religious self-knowledge and professional self-perfection. Scientific publications he considered to be hypothetical and dogmatic, be it in theology or medicine; moreover, their authors were often enough driven by their self-love and desire for fame. In his eyes, the only godly way of knowledge acquisition was the humble, diligent and minute study of divine creation according to the Hippocratic method. The most immediate and reliable way of achieving true wisdom, however, was the observation of God's work within one's own body and mind, which were subject to the effects of God's grace and punishment as well as to atmospheric, environmental and dietetic circumstances. (shrink)

Iring Fetscher (geb. 1922) lehrte von 1963 bis 1987 Politikwissenschaft an der Johann Wolfgang Goethe-Universität Frankfurt/M. Seine Studien zu Rousseau, seine Forschung im Umfeld des westeuropäischen Marxismus, sein Einsatz gegen Konservatismus und Technokratie und sein menschenrechtlicher Humanismus machen ihn zu einem streitbaren Intellektuellen, seine Märchenbücher zu einem bekannten Schriftsteller. Der Reichweite seines Schaffens und Wirkens gemäß sind in dieser Festschrift zu seinem 80. Geburtstag Beiträge von Weggefährten und Freunden versammelt, die Anstöße geben wollen für ein weiteres Gedeihen zentraler Aspekte seines (...) Denkens. Berührte Themen sind u. a. die Menschenrechte, Probleme der Globalisierung, der moderne Kulturkonflikt und die Zukunft der Demokratie. (shrink)

A plethora of ethical issues in livestock agriculture has emerged to public attention in recent decades, of which environmental and animal welfare concerns are but two, albeit prominent, themes. For livestock agriculture to be considered sustainable, somehow these interconnected themes need to be addressed. Ethical debate on these issues has been extensive, but mostly started from and focused on single issues. The views of farmers in these debates have been largely absent, or merely figured as interests, instead of being considered (...) morally worthwhile themselves. In this paper the relevance for ethical debates of the ways farmers discuss and engage with moral concerns is explored. The variety of norms that figure in contemporary farming practices is sketched in its multifarious complexity, illustrated by ethnographic fieldwork, and systematized in terms of “orders of worth.” Reviewing the practical arguments and commitments of farmers within this framework reveals that farming practices are subject to mixed motives, in which an amalgam of types of concerns play a role. Recognition of the peculiarly entangled nature of the ethics of farming practices could counter the tendency in policy making, technological innovation, and ethical thought to compartmentalize our moral landscape. Understanding farming practice as the integration of a mosaic of concerns in the light of a variety of moral experiences would foster public appreciation of positions of farmers in debates on improving the sustainability and societal acceptability of livestock agriculture. (shrink)

Ethical concerns regarding agricultural practices can be found to co-evolve with technological developments. This paper aims to create an understanding of ethics that is helpful in debating technological innovation by studying such a co-evolution process in detail: the development and adoption of the milking robot. Over the last decade an increasing number of milking robots, or automatic milking systems (AMS), has been adopted, especially in the Netherlands and a few other Western European countries. The appraisal of this new technology in (...) ethical terms has appeared to be a complicated matter. Compared to using a conventional milking parlor, the use of an AMS entails in several respects a different practice of dairy farming, the ethical implications and evaluation of which are not self-evident but are themselves part of a dynamic process. It has become clear that with its use, the entire practice of dairy farming has been reorganized around this new device. With a robot, cows must voluntarily present themselves to be milked, whereby an ethical norm of (individual) freedom for cows can be seen to emerge together with this new technology. But adopting a robot also implies changes in what is considered to be a good farmer and an appropriate relation between farmer and cow. Through interviews, attending “farmers’ network” meetings in the Netherlands, and studying professional literature and dedicated dairy farming web forums, this paper traces the way that ethical concerns are a dynamic part of this process of rearranging a variety of elements of the practice of dairy farming. (shrink)

Definition of the problem Compassionate use is the use of unapproved drugs in groups of patients suffering from a disease that, in the absence of an alternative treatment option, is life-threatening or leads to severe disability. Physicians are not in charge because access to the drug is only granted by pharmaceutical companies, which comes along with many ethical issues. Launched in 2020, the program of Onasemnogenum abeparvovecum against spinal muscular atrophy in children reached a new dimension. The intent of this (...) drug is to stop the progression of the disease with just a single dose, but the company limited the doses in the program to only 100. The global allocation was by lottery, which was considered a novelty in compassionate use history and therefore widely criticized. This paper investigates alternative allocation principles. Arguments Each possible principle is accompanied by many aspects that need to be considered with regard to urgency and global distribution. This makes some principles like first-come-first-served seem negligible. Remaining principles are ordered hierarchically to derive an algorithm that can represent an alternative to a lottery. A combination of willingness to participate in research, urgency, and likelihood of success (relative to the availability of supportive treatment options) may be considered in similar cases in future global compassionate use programs with children. Conclusion Since universal algorithms are difficult to define, allocation criteria should always be discussed by an independent panel of experts. Both the constitution of such a panel and its mandatory consultation are necessary in order to decrease the burden for all those involved and to prevent arbitrariness. (shrink)