Through their transcript products genes regulate the rates at which an immense variety of transcripts and subsequent proteins occur. Understanding the mechanisms that determine which genes are expressed, and when they are expressed, is one of the keys to genetic manipulation for many purposes, including the development of new treatments for disease. Viewing each gene in a genome as a distinct variable that is either on or off, or more realistically as a continuous variable, the values of some of these (...) variables influence the values of others through the regulatory proteins they express, including, of course, the possibility that the rate of expression of a gene at one time may, in various circumstances, influence the rate of expression of that same gene at a later time. If we imagine an arrow drawn from each gene expression variable at a given time to a gene variable whose expression it influences a short while after, the result is a network, technically a directed acyclic graph. For example, the DAG in Figure 1 is a representation of a system in which the expression level of gene G1 at time 1 ) causes the expression level of G2, which in turn causes the expression level of G3. The arrows in Figure 1 which do not have a variable at their tails are “error terms” which represent all of the causes of a variable other than the ones explicitly represented in the DAG. The DAG describes more than associations—it describes causal connections among gene expression rates. A shock to a cell—by mutation, heating, chemical treatment, etc. may alter the DAG describing the relations among gene expressions, for example by activating a gene that was otherwise not expressed, producing a cascade of new expression effects. Although “knockout” experiments can reveal some of the underlying causal network of gene expression levels, unless guided by information from other sources, such experiments are limited in how much of the network structure they can reveal, due to the sheer number of possible combinations of experimental manipulations of genes necessary to reveal the complete causal network. Recent developments have made it possible to compare quantitatively the expression of tens of thousands of genes in cells from different sources in a single experiment, and to trace gene expression over time in thousands of genes simultaneously. cDNA microarrays are already producing extensive data, much of it available on the web. Thus there are calls for analytic software that can be applied to microarray and other data to help infer regulatory networks. In this paper we will review current techniques that are available for searching for the causal relations between variables, describe algorithmic and data gathering obstacles to applying these techniques to gene expression levels, and describe the prospects for overcoming these obstacles. (shrink)

Mathematics reinterpreted as political practice and not just as theory constitutes an extraordinary exercise in democracy: like democracy, it is based on a system of rules, creates groups, and works on relationships. Like democracy, mathematics widens but doesn't nullify things. By studying mathematics one can understand many things about truth. For instance, the fact that truths are shared and therefore the principles of authority do not exist; the fact that all truths are absolute but transient because they depend on the (...) set of definitions and on the surrounding conditions. Solving a mathematical problem is an exercise in democracy because those who do not accept error and do not strive to understand the world are not able to change or govern it. In her polemical pamphlet Chiara Valerio pieces together a parallel between mathematics and democracy, two fields that do not succumb to the dictatorship of urgency--Translated from back cover. (shrink)

The last decade has seen great progress in the study of the nature of crossmodal links in exogenous and endogenous spatial attention . Exogenous spatial cuing studies of human crossmodal attention and multisensory integration. In C. Spence, & J. Driver , Crossmodal space and crossmodal attention . Oxford, UK: Oxford University Press.], for a recent review). A growing body of research now highlights the existence of robust crossmodal links between auditory, visual, and tactile spatial attention. However, until recently, studies of (...) exogenous and endogenous attention have proceeded relatively independently. In daily life, however, these two forms of attentional orienting continuously compete for the control of our attentional resources, and ultimately, our awareness. It is therefore critical to try and understand how exogenous and endogenous attention interact in both the unimodal context of the laboratory and the multisensory contexts that are more representative of everyday life. To date, progress in understanding the interaction between these two forms of orienting has primarily come from unimodal studies of visual attention. We therefore start by summarizing what has been learned from this large body of empirical research, before going on to review more recent studies that have started to investigate the interaction between endogenous and exogenous orienting in a multisensory setting. We also discuss the evidence suggesting that exogenous spatial orienting is not truly automatic, at least when assessed in a crossmodal context. Several possible models describing the interaction between endogenous and exogenous orienting are outlined and then evaluated in terms of the extant data. (shrink)

We ordinarily believe that the inhabitants of the world - including ourselves - persist over time. Such an idea, however, has puzzled philosophers for centuries. How can we change and still be the same? More specifically, is there any constitutive condition of our identity over time? And if so, does this condition involve mental aspects, physical aspects, or something else? Or is rather personal identity primitive and unanalyzable, so that our persistence is nothing but a brute fact? This volume is (...) a collection of new essays from leading figures in the field analyzing the persistence of persons and the criteria of personal identity over time. It presents an extensive discussion of the most relevant views on personal identity in contemporary metaphysics and provides new treatments of the constitutive conditions of personal persistence. (shrink)

The 2005 Report on Social Responsibility and Health of the UNESCO International Bioethics Committee (Ibc) proposes a new approach to implementing the right to healthcare and suggests a number of Courses of Action to be followed in various fields. Based on the latest available data, we intend to present an overview of the current state of European health systems in two of those fields—decision-making procedures and quality assurance in health care—and to attempt a comparison of the situation with the Report’s (...) provisions, in order to pave the way for the identification of what still has to be done to bridge international recommendations and the reality of policy and practice in Europe’s health care. (shrink)

The paper is focused on the criticisms that theorists of political constitutionalism raise against legal constitutionalism, especially with regard to the idea of representation and political sovereignty. At the same time, the intention is to reconstruct the debate between legal and political constitutionalism in contemporary liberalism, starting from the so-called counter-majoritarian difficulty. This debate concerns two different approaches: the political one rejects the idea of judicial review by the Supreme Court because it may establish a possible rule of the judges (...) (Michelman; Dworkin). It defends the role of Parliament in constitutional matters, in contrast with the role of the Supreme Court, inasmuch as – according to them – it is not open to political participation. Parliament is considered the only place in which we can exercise our constitutional power and in which our rights could be adequately protected (Bellamy; Waldron; Tushnet; Goldoni). On the other hand, legal constitutionalism upholds the idea of judicial review, defending the role of the Supreme Court as “exemplar of public reason” (Rawls 1993). This article tries to answer to three fundamental questions about constitutional democracy under the banner of political liberalism: 1. What do we mean by counter-majoritarian difficulty? 2. What is the answer that legal and political model of constitutionalism give to this question? 3. What is the role of constitutional courts in democratic regimes and what is their authority within the State? (shrink)

Abstract:There is a storied history of Native and Indigenous feminisms on Turtle Island (North America). We are fortunate that many of those stories birthed from an ancestral tradition of storytelling and survivance were captured in the canonical feminist anthology This Bridge Called My Back: Writings of Radical Women of Color. In celebration and commemoration of 40 years since This Bridge was first published we visit with three of the books original Native and Indigenous contributors–Chrystos, Max Wolf Valerio, and Jo (...) Carrillo–to recount old as well as new stories as they explore what Native and Indigenous feminisms mean to them and their continued work for Indigenous visibility. The conversation provides a unique intergenerational vision for conceptualizing contemporary Native and Indigenous feminisms all the while building upon the legacy and path set forth by amazing Native and Indigenous women trailblazers. (shrink)

La contaduría pública se ha vuelto una profesión importante en la actualidad, dado el cargo de confianza que asumen dentro de una institución al ser los emisores de información financiera relevante para la gerencia o la alta dirección. A su vez, es importante resaltar la gran cantidad de casos relacionados con la pérdida de valores y actos de corrupción que se presentan a diario en los medios de comunicación, la cual refleja la falta de ética de los profesionales a la (...) hora de ejercer sus funciones. En este contexto, se resalta el concepto de ética profesional, el cual garantiza el buen desempeño de un profesional bajo una serie de normas éticas que regulan su comportamiento. Por ello, el objetivo del presente artículo fue explorar el rol de la ética profesional en la formación y el ejercicio profesional del contador público. Los datos y consejos proporcionados por un contador definen en gran medida las decisiones tomadas respecto a la estructura financiera de una empresa u organización, razón por la cual un contador debe ser una persona íntegra e interesada en perseguir el interés general. Dadas las deficiencias existentes en la integridad ética y moral de los contadores, tanto universidades como empresas están implementando medidas para combatir este problema, buscando fortalecer la confianza de la población en la contaduría y prevenir que los futuros profesionales caigan en prácticas inmorales que dañan a la sociedad. (shrink)

The purpose of this article is to investigate one of the most interesting and debated issues within the philosophical dis-cussion about politics: the metaphor of the body politic and its relation with the theory of sovereignty in contemporary political theory. After an opening section, which proposes a brief sketch about the origin of the body politic within phi-losophy (especially in Plato’s and Aristotle’s contributions), the article provides a theoretical insight of such a theory, by dealing with three of its definitions: (...) Kantorowicz’s “king’s two bodies”; Hobbes’ Leviathan and Schmitt’s theory of sovereignty. The article aims at presenting some arguments to de-fine these three perspectives, by examining – in the last sec-tion – how this paradigm has evolved into the more complex and articulated theory of the rule of law in contemporary democratic societies. (shrink)

This article wants to propose some reflections on law, power and violence in contemporary political philosophy. My attention will be devoted to a critical analysis of some relevant contribution on these matters by prominent scholars and authors such as Alessandro Ferrara, Christoph Menke, Walter Benjamin, Hannah Arendt. The first part is dedicated to a brief introduction in which the Alessandro Ferrara’s reading of Menke’s Law and Violence will be presented. The second part focuses its attention on the philosophical backgrounds of (...) violence, especially in its relation to liberty, power and government. In this case, the main focus is devoted to some of the classics in political philosophy: Niccolò Machiavelli; Thomas Hobbes; Hannah Arendt. The last two paragraphs are finally dedicated to further reflections on law and violence. On the one hand, giving a deeper description of Ferrara’s remarks on Menke’s work, especially in its connection to Rawlsian political liberalism. The last paragraph, on the other hand, proposes few brief and final reflections on law and violence. (shrink)

Reasonable disagreement is one of the most critical issues in contemporary political philosophy, especially within liberal-democratic constitutionalism. In emphasising the role of disagreement in the relationship between discourse and politics, many scholars such as Jeremy Waldron and Richard Bellamy – against the background of the Rawlsian idea of “reasonable pluralism” – defend the thesis of moral disagreement as the core of political deliberation. By refusing the idea of neutrality, these authors maintain that political discourse cannot be established by simply removing (...) our moral disagree- ment on political values. This essay engages the issue of “discourse and politics” by focusing on some relevant topics: the deliberative conception of democracy; the Rawlsian idea of public reason as a forum for deliberation and discourse; the fact of disagreement and its inuence on the deliberative process. In order to investigate such issues, the paper follows three ways. First, it aims at examining John Rawls’ idea of public reason, by presenting it as a tool to resolve reasonable disagreement in the context of constitutional essentials. The second section deals with reasonable disagreement from a liberal point of view, by trying to focus on some critical remarks which Bellamy raises against Rawlsian political lib- eralism. The third section briefly analyses Waldron’s arguments in defence of reasonable disagreement, as a critique of the deliberative model of democracy. From this perspective, Waldron presents deliberative democracy’s failure in considering political dissent and moral disagreement as two problematic aspects of democracy. (shrink)

No presente trabalho são expostas e examinadas as críticas eudemonistas de Gottlob August Tittel (1739-1816) à Fundamentação da metafísica dos costumes, a partir da alusão indirecta de Kant a elas no Prefácio à Crítica da razão prática. Por outro lado, são também fornecidas em apêndice as informações, constantes na correspondência de Hamann, de que Kant com aquela primeira obra de filosofia moral preparava uma crítica ao eudemonismo similar de Garve, expresso em seus comentários ao De officiis de Cícero. O artigo (...) fornece assim o contexto polémico de surgimento dessas obras práticas, no qual Kant não se deixou envolver directamente, mas só teórica e argumentativamente. /// The present article aims at an exposition and an examination of the eudemonistic criticisms of Gottlieb August Tittel (1739-1816) to Kant's Grundlegung der Metaphysik der Sitten. This goal shall be achieved through an indirect reference to those criticisms as they appear in the Preface to the Kritik der praktischen Vernunft On the other hand, however, the article also gives information related to the fact that, as it appears in Kant's correspondence with Hamann, in publishing his first work in the realm of moral philosophy Kant was also preparing a critical review of Garve's similar eudemonism, as it is expressed in his commentaries to Cicero's De officiis. The article offers thus the polemic context for the emergence of those Kantian works in the realm of practical philosophy, being demonstrated that Kant did not allow himself to be involved directly in them, but only in a theoretic and argumentative way. (shrink)

The paper exhibits the relation between Heidegger’s idea of Andenken and one of the main concepts of Gadamer’s hermeneutics, viz., tradition, in the following way: tradition is interpreted from Andenken. In order to clarify this relation it was necessary to present the features of tradition pr..

La interpretación narrativa es un modo de conectar la obra de arte con la historia y a partir de ahí configurar la identidad narrativa en términos dinámicos. La interpretación narrativa es un camino viable para el pensar cuando éste trata de dar cuenta de formas problemáticas de arte, como el arte actual, ya que tiene la ventaja de trabajar con el contexto de la obra en vez de tratarla aisladamente. Una obra es lo que es gracias a sus conexiones con (...) obras anteriores y posteriores. La narratividad es probablemente el mejor modo de establecer, explicar y comprender estas conexiones. El objetivo de este artículo es mostrar que puede haber un tipo de interpretación que configure la identidad narrativa de la obra y que esta identidad no se restringe a la identificación, sino que crea una identidad dinámica para la obra. (shrink)

We discuss models that attempt to provide an explanation for the violation of Bell inequalities at a distance in terms of hidden influences. These models reproduce the quantum correlations in most situations, but are restricted to produce local correlations in some configurations. The argument presented in (Bancal et al. Nat Phys 8:867, 2012) applies to all of these models, which can thus be proved to allow for faster-than-light communication. In other words, the signalling character of these models cannot remain hidden.

Kant era um conhecedor da filosofia estoica e, por isso, sofreu influência direta sobre suas formulações éticas. O presente artigo visa, então, a estabelecer uma relação entre a fórmula proposta por Cícero e a “nova fórmula” proposta por Kant. Defende, ainda, que a ideia de formula como lei ética, proposta por Cícero, encontra no Imperativo Categórico de Kant sua expressão final. Além disso, mostra que a ética kantiana é uma reelaboração das teses do De officiis, de Cícero, o que nos (...) deixa entender por que Kant retoma vários termos antigos, ligados, no entanto, a um total novo significado. Por último, busca explicitar duas inquietações, nomeadamente, se não se pode conceber uma utilidade do indivíduo que não tenha diretamente a ver com uma utilidade de tipo moral; e, segundo, como se pode relacionar textualmente a fórmula do imperativo categórico de Kant com a ética de Cícero. (shrink)

No presente trabalho são expostas e examinadas as críticas eudemonistas de Gottlob August Tittel (1739-1816) à Fundamentação da metafísica dos costumes, a partir da alusão indirecta de Kant a elas no Prefácio à Crítica da razão prática. Por outro lado, são também fornecidas em apêndice as informações, constantes na correspondência de Hamann, de que Kant com aquela primeira obra de filosofia moral preparava uma crítica ao eudemonismo similar de Garve, expresso em seus comentários ao De officiis de Cícero. O artigo (...) fornece assim o contexto polémico de surgimento dessas obras práticas, no qual Kant não se deixou envolver directamente, mas só teórica e argumentativamente. (shrink)