Rationale: Deep brain stimulation (DBS) of the hippocampus is proposed for enhancement of memory impaired by injury or disease. Many pre-clinical DBS paradigms can be addressed in epilepsy patients undergoing intracranial monitoring for seizure localization, since they already have electrodes implanted in brain areas of interest. Even though epilepsy is usually not a memory disorder targeted by DBS, the studies can nevertheless model other memory-impacting disorders, such as Traumatic Brain Injury (TBI). Methods: Human patients undergoing Phase II invasive monitoring for (...) intractable epilepsy were implanted with depth electrodes capable of recording neurophysiological signals. Subjects performed a delayed-match-to-sample (DMS) memory task while hippocampal ensembles from CA1 and CA3 cell layers were recorded to estimate a multi-input, multi-output (MIMO) model of CA3-to-CA1 neural encoding and a memory decoding model (MDM) to decode memory information from CA3 and CA1 neuronal signals. After model estimation, subjects again performed the DMS task while either MIMO-based or MDM-based patterned stimulation was delivered to CA1 electrode sites during the encoding phase of the DMS trials. Each subject was sorted (post hoc) by prior experience of repeated and/or mild-to-moderate brain injury (RMBI), TBI, or no history (control) and scored for percentage successful delayed recognition (DR) recall on stimulated vs. non-stimulated DMS trials. The subject’s medical history was unknown to the experimenters until after individual subject memory retention results were scored. Results: When examined compared to control subjects, both TBI and RMBI subjects showed increased memory retention in response to both MIMO and MDM-based hippocampal stimulation. Furthermore, effects of stimulation were also greater in subjects who were evaluated as having pre-existing mild-to-moderate memory impairment. Conclusion: These results show that hippocampal stimulation for memory facilitation was more beneficial for subjects who had previously suffered a brain injury (other than epilepsy), compared to control (epilepsy) subjects who had not suffered a brain injury. This study demonstrates that the epilepsy/intracranial recording model can be extended to test the ability of DBS to restore memory function in subjects who previously suffered a brain injury other than epilepsy, and support further investigation into the beneficial effect of DBS in TBI patients. (shrink)

In this important book, Susan Hurley sheds new light on consciousness by examining its relationships to action from various angles. She assesses the role of agency in the unity of a conscious perspective, and argues that perception and action are more deeply interdependent than we usually assume. A standard view conceives perception as input from world to mind and action as output from mind to world, with the serious business of thought in between. Hurley criticizes this picture, and considers (...) how the interdependence of perceptual experience and agency at the personal level (of mental contents and norms) may emerge from the subpersonal level (of underlying causal processes and complex dynamic feedback systems). Her two-level view has wide implications, for topics that include self-consciousness, the modularity of mind, and the relations of mind to world. The self no longer lurks hidden somewhere between perceptual input and behavioral output, but reappears out in the open, embodied and embedded in its environment. Hurley traces these themes from Kantian and Wittgensteinian arguments through to intriguing recent work in neuropsychology and in dynamic systems approaches to the mind, providing a bridge from mainstream philosophy to work in other disciplines. Consciousness in Action is unique in the range of philosophical and scientific work it draws on, and in the deep criticism it offers of centuries-old habits of thought. (shrink)

The Flight to Objectivity offers a new reading of Descartes' Meditations informed by cultural history, psychoanalytic and cognitive psychology, and feminist thought.

The concept of "fitness" is a notion of central importance to evolutionary theory. Yet the interpretation of this concept and its role in explanations of evolutionary phenomena have remained obscure. We provide a propensity interpretation of fitness, which we argue captures the intended reference of this term as it is used by evolutionary theorists. Using the propensity interpretation of fitness, we provide a Hempelian reconstruction of explanations of evolutionary phenomena, and we show why charges of circularity which have been levelled (...) against explanations in evolutionary theory are mistaken. Finally, we provide a definition of natural selection which follows from the propensity interpretation of fitness, and which handles all the types of selection discussed by biologists, thus improving on extant definitions. (shrink)

A traditional view of perception and action makestwo assumptions: that the causal flow betweenperception and action is primarily linear or one-way,and that they are merely instrumentally related toeach other, so that each is a means to the other.Either or both of these assumptions can be rejected. Behaviorism rejects the instrumental but not theone-way aspect of the traditional view, thus leavingitself open to charges of verificationism. Ecologicalviews reject the one-way aspect but not theinstrumental aspect of the traditional view, so thatperception and (...) action are seen as instrumentallyinterdependent. It is argued here that a betteralternative is to reject both assumptions, resultingin a two-level interdependence view in whichperception and action co-depend on dynamicallycircular subpersonal relations and as a result may bemore than merely instrumentally interdependent. Thisis illustrated by reference to motor theories ofperception and control theories of action. (shrink)

and apply it to various examples of neural plasticity in which input is rerouted intermodally or intramodally to nonstandard cortical targets. In some cases but not others, cortical activity ‘defers’ to the nonstandard sources of input. We ask why, consider some possible explanations, and propose a dynamic sensorimotor hypothesis. We believe that this distinction is important and worthy of further study, both philosophical and empirical, whether or not our hypothesis turns out to be correct. In particular, the question of how (...) the distinction should be explained is linked to explanatory gap issues for consciousness. Comparative and absolute explanatory gaps should be distinguished: why does neural activity in a particular area of cortex have this qualitative expression rather than that, and why does it have any qualitative expression at all? We use the dominance/deference distinction to address the comparative gaps, both intermodal and intramodal. We do so not by inward scrutiny but rather by expanding our gaze to include relations between brain, body and environment. (shrink)

Susan James explores the revolutionary political thought of one of the most radical and creative of modern philosophers, Baruch Spinoza. His Theologico-Political Treatise of 1670 defends religious pluralism, political republicanism, and intellectual freedom. James shows how this work played a crucial role in the development of modern society.

It is often taken for granted by writers who propose--and, for that matter, by writers who oppose--'justifications' of inductions, that deduction either does not need, or can readily be provided with, justification. The purpose of this paper is to argue that, contrary to this common opinion, problems analogous to those which, notoriously, arise in the attempt to justify induction, also arise in the attempt to justify deduction.

Hermeneutic research in nursing: developing a Gadamerian‐based research method This paper takes the stance that although there are many different approaches to phenomenological and hermeneutic research, some of these have become blurred due to multiple interpretations of translated materials. Working from original texts by the German philosophers, this paper reconsiders the relevance of phenomenology and hermeneutics to nursing research. We trace the development of Gadamer's philosophy in order to propose a research method based in this tradition. Five steps have been (...) identified as a guide for nurse researchers. These are deciding upon a question, identification of preunderstandings, gaining understanding through dialogue with participants, gaining understanding through dialogue with text and establishing trustworthiness. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Philosophy and Literature 31.1 (2007) 189-196MuseSearchJournalsThis JournalContents[Access article in PDF]Fiction and Theory of Mind: An ExchangeLisa Zunshine University of KentuckyBrian Boyd's review of my new book, Why We Read Fiction: Theory of Mind and the Novel (Ohio State University Press, 2006) engages a large variety of issues.1 I would like to address an important question about the integration of scientific methodology with literary analysis suggested by Boyd's discussion.2 As (...) I argue below, two different perspectives of this integration may mark two different—indeed, incompatible—ways of formulating the disciplinary goals and philosophy of the new field of cognitive literary theory.Why We Read Fiction makes a case for admitting the recent findings of cognitive psychologists into literary studies by showing how their research into the ability to explain behavior in terms of the underlying states of mind can furnish us with a series of surprising insights into our interaction with literary texts. Using as my case studies novels ranging from Richardson's Clarissa, Dostoyevsky's Crime and Punishment, and Austen's Pride and Prejudice to Woolf's Mrs. Dalloway, Nabokov's Lolita, and Hammett's The Maltese Falcon, I advance and explore a series of hypotheses about cognitive cravings that are satisfied—and created!—when we read fiction.Although my study draws on the already well-established as well as forthcoming work of numerous cognitive scientists (including Simon Baron-Cohen, Clark H. Barrett, Richard Byrne and Andrew Whiten, Leda Cosmides and John Tooby, Christopher Frith, Uta Frith, Paul Bloom, Susan Carey and Elizabeth Spelke, Peter Carruthers, Andy Clark, Antonio Damasio, Daniel Dennett, Alison Gopnik, Francesca Happe, Paul [End Page 189] Harris, Lawrence Hirschfeld, Stanley Klein, Alan Leslie, Andrew Meltzoff, Robert Mitchell, Keith Oatley, Gloria Origgi, Oliver Sacks, Dan Sperber, James Stiller, and Endel Tulving), it makes a point of being accessible to non-specialist readers. Cognitive science can be incredibly complicated and so can literary criticism, but I wanted to write a book on cognitive literary theory that does not scare anybody away with unnecessary jargon, knotty sentences, and overlong quotations. (Ironically, I must have succeeded too well in making my book reader-friendly and tucking my references in the endnotes since Boyd observes that I rely on only "a few findings" of cognitive scientists in my discussion.)The book consists of three parts. The first part, "Attributing Minds," introduces the first key theoretical concept of this book: mind-reading, also known as Theory of Mind. Drawing on the work of Simon Baron-Cohen (Mindblindness: An Essay on Autism and Theory of Mind), I suggest that fiction engages, teases, and pushes to its tentative limits our mind-reading capacity. Building on the recent research of Robin Dunbar and his colleagues, I then consider one particular aspect of Woolf's prose as an example of spectacular literary experimentation with our Theory of Mind. Finally, I turn to Steven Pinker's controversial analysis of Woolf in The Blank Slate to discuss the possibilities of a more profitable dialogue between cognitive science and literary studies.Of particular importance to this part of my argument is my belief that fictional narratives endlessly experiment with rather than automatically execute our evolved cognitive adaptations. When cognitive scientists succeed in isolating a certain regularity of our information-processing—for example, a constraint on the number of mutually reflecting minds that we can process with ease—we can take that constraint and see how it plays itself out in a fictional narrative. What we discover is that where there is a cognitive constraint, there is a "guarantee" of sorts that writers will intuitively experiment in the direction of challenging that constraint, probing and poking it and getting around it. The exact forms of such probing and poking will depend on specific cultural circumstances, including the mind-reading profiles of individual writers and their readers. The cognitive "limits" thus present us with creative openings rather than with a promise of stagnation and endless replication of established forms. This realization marks the possibility of a genuine interaction between cognitive psychology and... (shrink)

This introductory chapter explains the coverage of this book, which is about animal rationality and mental processing in animals. This book discusses the theoretical issues and distinctions that bear on attributions of rationality to animals and draws some contrasts between rationality and certain other traits of animals to determine the relationships between them. It explores the relations between behaviour and the processes that explain behaviour, and the senses in which animal behaviour might be rational in virtue of features other than (...) classical reasoning processes on the human model. -/- . (shrink)

I defend the view that we should not overintellectualize the mind. Nonhuman animals can occupy islands of practical rationality: they can have contextbound reasons for action even though they lack full conceptual abilities. Holism and the possibility of mistake are required for such reasons to be the agent's reasons, but these requirements can be met in the absence of inferential promiscuity. Empirical work with animals is used to illustrate the possibility that reasons for action could be bound to symbolic or (...) social contexts, and connections are made to simulationist accounts of cognitive skills. (shrink)

Leading scholars continue the debate over whether consciousness causes behavior or plays no functional role in it, discussing the question in terms of neuroscience, philosophy, law, and public policy.

How do our personalities and mental processes, our " states of consciousness" , derive from a gray mass of tissue with the consistency of a soft-boiled egg? How can mere molecules constitute an idea or emotion? Some of the most important questions we can ask are about our own consciousness. Our personalities, our individuality, indeed our whole reason for living, lie in the brain and in the elusive phenomenon of consciousness it generates. Thinkers in many disciplines have long struggled with (...) such questions, often in ways that have seemed incompatible, if not downright contradictory. Philosophers have meditated on the subjective experience of consciousness, with little attention to the physical realm, while scientists have sought to establish a causal relation between brain function and mind, often ignoring the qualitative aspects of experience. In Journey to the Centers of the Mind, neuroscientist Susan Greenfield offers an intriguing, unifying theory of consciousness that encompasses both phenomenological mental events and physical aspects of brain function. Using information gathered from clues in animal behavior, human brain damage, computer science, neurobiology, and philosophy, Greenfield offers a " concentric theory" of consciousness, and shows how certain events in the brain correspond to our qualitative experience of the world. Demonstrating the ways in which we can interpret the experience of consciousness in terms of interactions among neurons, she explores how much we can learn by continuing to find the links between our physical and mental inner worlds. (shrink)

Background: Hospitals are experiencing an estimated 16.5% turnover rate of registered nurses costing from $44,380 - $63,400 per nurse—an estimated $4.21 to $6.02 million financial loss annually for hospitals in the United States of America. Attrition of all nurses is costly. Most past research has focused on the new graduate nurse with little focus on the mid-career nurse. Attrition of mid-career nurses is a loss for the profession now and into the future. Research objective: The purpose of the study was (...) to explore relationships of professional values orientation, career development, job satisfaction, and intent to stay in recently hired mid-career and early-career nurses in a large hospital system. Research design: A descriptive correlational study of personal and professional factors on job satisfaction and retention was conducted. Participants and research context: A convenience sample of nurses from a mid-sized hospital in a metropolitan area in the Southwestern United States was recruited via in-house email. Sixty-seven nurses met the eligibility criteria and completed survey documents. Ethical considerations: Institutional Review Board approval was obtained from both the university and hospital system. Findings: Findings indicated a strong correlation between professional values and career development and that both job satisfaction and career development correlated positively with retention. Discussion: Newly hired mid-career nurses scored higher on job satisfaction and planned to remain in their jobs. This is important because their expertise and leadership are necessary to sustain the profession into the future. Conclusion: Nurse managers should be aware that when nurses perceive value conflicts, retention might be adversely affected. The practice environment stimulates nurses to consider whether to remain on the job or look for other opportunities. (shrink)

Background Dynamic consent has been proposed as a process through which participants and patients can gain more control over how their data and samples, donated for biomedical research, are used, resulting in greater trust in researchers. It is also a way to respond to evolving data protection frameworks and new legislation. Others argue that the broad consent currently used in biobank research is ethically robust. Little empirical research with cohort study participants has been published. This research investigated the participants’ opinions (...) of adding a dynamic consent interface to their existing study. Methods Adult participants in the Extended Cohort for E-health, Environment and DNA longitudinal cohort study who are members of the EXCEED Public and Participant Engagement Group were recruited. Four focus groups were conducted and analysed for thematic content. Discussion topics were derived from a review of the current literature on dynamic consent. Results Participants were in favour of many aspects of a dynamic consent interface, such as being able to update their information, add additional data to their records and choose withdrawal options. They were supportive provided it was simple to use and not intrusive. Participants expressed a markedly high level of trust in the study and its investigators and were unanimously happy with their current participation. No strong support was found for adding a dynamic consent interface to EXCEED. Conclusions Trust in the study researchers was the strongest theme found. Openness and good data security were needed to retain their trust. While happy to discuss dynamic consent, participants were satisfied with the current study arrangements. There were indications that changing the study might unnecessarily disturb their trust. This raised the question of whether there are contexts where dynamic consent is more appropriate than others. This study was limited by the small number of participants who were committed to the study and biased towards it. More research is needed to fully understand the potential impact of adding a dynamic consent interface to an existing cohort study. (shrink)

I argue that an ecologically distributed conception of instrumental rationality can and should be extended to a socially distributed conception of instrumental rationality in social environments. The argument proceeds by showing that the assumption of exogenously fixed units of activity cannot be justified; different units of activity are possible and some are better means to independently given ends than others, in various circumstances. An important social heuristic, the mirror heuristic, enables the flexible formation of units of activity in game theoretic (...) situations, including collective units where these are instrumentally effective. In effect, the mirror heuristic makes the formation of units of activity endogenous to instrumental rationality. Moreover, the mirror heuristic is a conditional metaheuristic, which depends on mind reading of the heuristics of other players rather than on predictions of their behavior. Such mind reading can be regarded as emerging from an arms race between behavioral mimicry and ever smarter behavior reading. Even though unilateral mind reading may have benefits, the mirror metaheuristic illustrates that mutual mind reading has distinctive functions in responding to the challenges of social complexity. If simple heuristics can make us smart in the right environments, then social heuristics can make us smarter still. (shrink)

This is a study of the central questions of explanation in the social sciences, and a defence of 'holism' against 'individualism'. In the first half of the book Susan James sets out very clearly the philosophical background to this controversy. She locates its source not at the analytical level at which most of the debate is usually conducted but at a more fundamental, moral level, in different conceptions of the human individual. In the second half of the book she (...) examines critically three case studies of holistic approaches - Althusser, Poulantzas and the Annales historians - and progressively refines our sense of the strengths and deficiencies of their programmes. She ends by arguing for a form of concessive holism, which offers some accommodation to liberal conceptions of individual autonomy but continues to emphasise the explanatory importance of social regularities and environments. (shrink)

Experimental engineering models have been used both to model general phenomena, such as the onset of turbulence in fluid flow, and to predict the performance of machines of particular size and configuration in particular contexts. Various sorts of knowledge are involved in the method - logical consistency, general scientific principles, laws of specific sciences, and experience. I critically examine three different accounts of the foundations of the method of experimental engineering models (scale models), and examine how theory, practice, and experience (...) are involved in employing the method to obtain practical results. Models of machines and mechanisms can be (and generally are) involved in establishing criteria for similar phenomena, which provide guidance in using events to model other events. Conversely, models of phenomena such as events that model other events can be (and generally are) involved in experimentation on models of machines. I conclude that often it is not more detailed models or the more precise equations they engender that leads to better understanding, but rather an insightful use of knowledge at hand to determine which similarity principles are appropriate in allowing us to infer what we do not know from what we are able to observe. (shrink)

In this book, Susan Mendus seeks to address these important questions to assess whether this apparent tension between morality and politics is real and, if so, ...

It is known that a number of inference principles can be used to trivialise the axioms of naïve comprehension - the axioms underlying the naïve theory of sets. In this paper we systematise and extend these known results, to provide a number of general classes of axioms responsible for trivialising naïve comprehension.

On a literal reading of `Computing Machinery and Intelligence'', Alan Turing presented not one, but two, practical tests to replace the question `Can machines think?'' He presented them as equivalent. I show here that the first test described in that much-discussed paper is in fact not equivalent to the second one, which has since become known as `the Turing Test''. The two tests can yield different results; it is the first, neglected test that provides the more appropriate indication of intelligence. (...) This is because the features of intelligence upon which it relies are resourcefulness and a critical attitude to one''s habitual responses; thus the test''s applicablity is not restricted to any particular species, nor does it presume any particular capacities. This is more appropriate because the question under consideration is what would count as machine intelligence. The first test realizes a possibility that philosophers have overlooked: a test that uses a human''s linguistic performance in setting an empirical test of intelligence, but does not make behavioral similarity to that performance the criterion of intelligence. Consequently, the first test is immune to many of the philosophical criticisms on the basis of which the (so-called) `Turing Test'' has been dismissed. (shrink)

The duration of “now” is shown to be important not only for an understanding of how conscious beings sense duration, but also for the validity of the phenomenological enterprise as Husserl conceived it. If “now” is too short, experiences can not be described before they become memories, which can be considered to be transcendent rather than immanent phenomena and therefore inadmissible as phenomenological data. Evidence concerning (a) the objective duration of sensations in various sensory modalities, (b) the time necessary for (...) sensations to enter consciousness and (c) the variability in the subjective sense of time's passing under different conditions is used to conclude that the duration of “now” can actually vary under normal conditions from about 10 ms to several seconds and in extreme cases up to several hours. Thus the immanent moment can be long enough to encompass a report of the contents of consciousness, making phenomenology a viable project. A further speculation from the evidence described is that consciousness takes discrete samples of the external world, at a rate inversely proportional to the duration of the “now” moment. (shrink)

Training in ethics and professionalism is a fundamental component of residency education, yet there is little empirical information to guide curricula. The objective of this study is to describe empirically derived ethics objectives for ethics and professionalism training for multiple specialties. Study design is a thematic analysis of documents, semi-structured interviews, and focus groups conducted in a setting of an academic medical center, Veterans Administration, and community hospital training more than 1000 residents. Participants were 84 informants in 13 specialties including (...) residents, program directors, faculty, practicing physicians, and ethics committees. Thematic analysis identified commonalities across informants and specialties. Resident and nonresident informants identified consent, interprofessional relationships, family interactions, communication skills, and end-of-life care as essential components of training. Nonresidents also emphasized formal ethics instruction, resource allocation, and self-monitoring, whereas residents emphasized the learning environment and resident-attending interactions. Conclusions are that empirically derived learning needs for ethics and professionalism included many topics, such as informed consent and resource allocation, relevant for most specialties, providing opportunities for shared curricula and resources. (shrink)

According to the language of thought (or.

Quine and Putnam argued for mathematical realism on the basis of the indispensability of mathematics to science. They claimed that the mathematics that is used in physical theories is confirmed along with those theories and that scientific realism entails mathematical realism. I argue here that current theories of confirmation suggest that mathematics does not receive empirical support simply in virtue of being a part of well confirmed scientific theories and that the reasons for adopting a realist view of scientific theories (...) do not support realism about mathematical entities, despite the use of mathematics in formulating scientific theory. (shrink)

Curry's paradox, sometimes described as a general version of the better known Russell's paradox, has intrigued logicians for some time. This paper examines the paradox in a natural deduction setting and critically examines some proposed restrictions to the logic by Fitch and Prawitz. We then offer a tentative counterexample to a conjecture by Tennant proposing a criterion for what is to count as a genuine paradox.

Dandruff is a common scalp condition, which frequently causes psychological distress in those affected. Dandruff is considered to be caused by an interplay of several factors. However, the pathogenesis of dandruff remains under‐investigated, especially with respect to the contribution of the hair follicle. As the hair follicle exhibits unique immune‐modulatory properties, including the creation of an immunoinhibitory, immune‐privileged milieu, we propose a novel hypothesis taking into account the role of the hair follicle. We hypothesize that the changes and imbalance of (...) yeast and bacterial species, along with increasing proinflammatory sebum by‐products, leads to the activation of immune response and inflammation. Hair follicle keratinocytes may then detect these changes in scalp microbiota resulting in the recruitment of leukocytes to the inflammation site. These changes in the scalp skin immune‐microenvironment may impact hair follicle immune privilege status, which opens new avenues into exploring the role of the hair follicle in dandruff pathogenesis. Also see the video abstract here: https://youtu.be/mEZEznCYtNs. (shrink)

Advocates of cognitive enhancement maintain that technological advances would augment autonomy indirectly by expanding the range of options available to individuals, while, in a recent article in this journal, Schaefer, Kahane, and Savulescu propose that cognitive enhancement would improve it more directly. Here, autonomy, construed in broad procedural terms, is at the fore. In contrast, when lauding the goodness of enhancement expressly, supporters’ line of argument is utilitarian, of an ideal variety. An inherent conflict results, for, within their utilitarian frame, (...) the content of rational, hence autonomous, choices is quite restricted. Further, advocates do not clearly indicate their relative emphasis between the often conflicting goals of maximizing benefit and avoiding harm. In practice, their construction of harms is highly expansive, for disabilities include any constraints that “rational” people would decline if it were technically possible to do so. For advocates, this means that where enhancement measures are available, those constraints become avoidable limitations, and not to remove them is to harm. The centrality of harm-avoidance and their ideal utilitarian frame entail sociopolitical requirements that enhancement defenders disallow when trumpeting autonomy in the vein of individual choice. Advocates have thus not done enough to support the claim that their views are wholly separate from earlier eugenics. (shrink)

Wollstonecraft's early works express a coherent view of moral psychology, moral education and moral philosophy which guides the construction of her early fiction and educational works. It includes a valuable account of the relation between reason and feeling in moral development. Failure to recognize the complexity and coherence of the view and unhistorical readings have led to mistaken criticisms of Wollstonecraft's position. Part I answers these criticisms; Part II describes and textually supports her view.