Dr. Sato's volume deals with the origin and formation of the political thought of pre-imperial Xun Zi, with close focus on this synthesizer's formative theory ...

In 2008, researchers created human three-dimensional neural tissue – known as the pioneering work of “brain organoids.” In recent years, some researchers have transplanted human brain organoids into animal brains for applicational purposes. With these experiments have come many ethical concerns. It is thus an urgent task to clarify what is ethically permissible and impermissible in brain organoid research. This paper seeks (1) to sort out the ethical issues related to brain organoid research and application and (2) to propose future (...) directions for additional ethical consideration and policy debates in the field. Toward (1), this paper first outlines the current state of brain organoid research, and then briefly responds to previously raised related ethical concerns. Looking next at anticipated scientific developments in brain organoid research, we will discuss (i) ethical issues related to in vitro brain organoids, (ii) ethical issues raised when brain organoids form complexes or have relationships with other entities, and (iii) ethical issues of research ethics and governance. Finally, in pursuit of (2), we propose research policies that are mindful of the ethics of brain organoid research and application and also suggest the need for an international framework for research and application of brain organoids. (shrink)

1. Seikyō ronkō -- 2-3. Shibunrui -- 4-10. Rangai shorui -- 11-12. Genshi shiroku -- 13-14. Fukureki.

An evaluation method, similar to the two-valued one for the classical logic, is introduced to give a decision procedure for some of intermediate logics. The logics treated here are obtained from some logics by adding the axiom av a.

一八世紀後半から一九世紀初頭の徳川期日本においてひとつの潮流を形成した本居宣長の古学古道論が、「世界を再‐結集する」信条や世界観をどのように創出しようとしたのかを、差異と反復をめぐる新たな思考を通して 考察する。.

We can easily discriminate self-produced from externally generated sensory signals. Recent studies suggest that the prediction of the sensory consequences of one’s own actions made by forward model can be used to attenuate the sensory effects of self-produced movements, thereby enabling a differentiation of the self-produced sensation from the externally generated one. The present study showed that attenuation of sensation occurred both when participants themselves performed a goal-directed action and when they observed experimenter performing the same action, although they clearly (...) reported that the tones were produced by other during action observation and by themselves during their own action. These results suggest that sensory prediction of action modulates ongoing auditory processing irrespective of who produces the sounds and that the explicit judgment of agency does not necessarily rely on the same mechanisms on which implicit perceptual measures such as sensory attenuation rely. (shrink)

A new research project has, quite recently, been launched to clarify how different, from systems in second order number theory extending ACA0, those in second order set theory extending NBG are. In this article, we establish the equivalence between Δ01-LFP\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$${\Delta^1_0\mbox{\bf-LFP}}$$\end{document} and Δ01-FP\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$${\Delta^1_0\mbox{\bf-FP}}$$\end{document}, which assert the existence of a least and of a fixed point, respectively, for positive elementary operators. Our proof also shows (...) the equivalence between ID1 and ID^1\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$${\widehat{\it ID}_1}$$\end{document}, both of which are defined in the standard way but with the starting theory PA replaced by ZFC. (shrink)

In this paper, we outline how one might conduct a comprehensive ethical evaluation of human brain organoid transplantation in animals. Thus far, ethical concerns regarding this type of research have been assumed to be similar to those associated with other transplants of human cells in animals, and have therefore not received significant attention. The focus has been only on the welfare, moral status, or mental capacities of the host animal. However, the transplantation of human brain organoids introduces several new ethical (...) issues. Many of these are related to uncertainty regarding whether or not brain organoids might be conscious. While these concerns might not be immediately relevant, they warrant closer scrutiny. We discuss how various ethical issues are relevant to different stages of human brain organoid transplantation and can guide the ethical evaluation of research. Our examination would broaden the horizons of the debate on the transplantation of brain organoids. (shrink)

By obtaining several new results on Cook-style two-sorted bounded arithmetic, this paper measures the strengths of the axiom of extensionality and of other weak fundamental set-theoretic axioms in the absence of the axiom of infinity, following the author’s previous work [K. Sato, The strength of extensionality I — weak weak set theories with infinity, Annals of Pure and Applied Logic 157 234–268] which measures them in the presence. These investigations provide a uniform framework in which three different kinds of (...) reverse mathematics–Friedman–Simpson’s “orthodox” reverse mathematics, Cook’s bounded reverse mathematics and large cardinal theory–can be reformulated within one language so that we can compare them more directly. (shrink)

We study filters in residuated structures that are associated with congruence relations (which we call -filters), and develop a semantical theory for general substructural logics based on the notion of primeness for those filters. We first generalize Stone’s sheaf representation theorem to general substructural logics and then define the primeness of -filters as being “points” (or stalkers) of the space, the spectrum, on which the representing sheaf is defined. Prime FL-filters will turn out to coincide with truth sets under various (...) well known semantics for certain substructural logics. We also investigate which structural rules are needed to interpret each connective in terms of prime -filters in the same way as in Kripke or Routley-Meyer semantics. We may consider that the set of the structural rules that each connective needs in this sense reflects the difficulty of giving the meaning of the connective. A surprising discovery is that connectives , ⅋ of linear logic are linearly ordered in terms of the difficulty in this sense. (shrink)

We introduce a new axiom called inductive dichotomy, a weak variant of the axiom of inductive definition, and analyze the relationships with other variants of inductive definition and with related axioms, in the general second order framework, including second order arithmetic, second order set theory and higher order arithmetic. By applying these results to the investigations on the determinacy axioms, we show the following. (i) Clopen determinacy is consistency-wise strictly weaker than open determinacy in these frameworks, except second order arithmetic; (...) this is an enhancement of Schweber–Hachtman separation of open and clopen determinacy into the consistency-wise separation. (ii) Hausdorff–Kuratowski hierarchy of differences of opens is faithfully reflected by the hierarchy of consistency strengths of corresponding parameter-free determinacies in the aforementioned frameworks; this result is valid also in second order arithmetic only except clopen determinacy. (shrink)

This article reports that some robustness of the notions of predicativity and of autonomous progression is broken down if as the given infinite total entity we choose some mathematical entities other than the traditionalω. Namely, the equivalence between normal transfinite recursion scheme and newdependent transfinite recursionscheme, which does hold in the context of subsystems of second order number theory, does not hold in the context of subsystems of second order set theory where the universeVof sets is treated as the given (...) totality. (shrink)

We highlight that the connection of well-foundedness and recursive definitions is more than just convenience. While the consequences of making well-foundedness a sufficient condition for the existence of hierarchies have been extensively studied, we point out that well-foundedness is a necessary condition for the existence of hierarchies e.g. that even in an intuitionistic setting α⊢wfwhereα\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$${_\alpha \vdash \mathsf{wf}\, {\rm where}\, _\alpha}$$\end{document} stands for the iteration of Π10\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} (...) \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$${\Pi^0_1}$$\end{document} comprehension along some ordinal α\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$${\alpha}$$\end{document} and wf\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$${\mathsf{wf}}$$\end{document} stands for the well-foundedness of α\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$${\alpha}$$\end{document}. (shrink)

The number of competing-brands changes by new product's entry. The new product introduction is endemic among consumer packaged goods firm and is an integral component of their marketing strategy. As a new product's entry affects markets, there is a pressing need to develop market response model that can adapt to such changes. In this paper, we develop a dynamic model that capture the underlying evolution of the buying behavior associated with the new product. This extends an application of a dynamic (...) linear model, which is used by a number of time series analyses, by allowing the observed dimension to change at some point in time. Our model copes with a problem that dynamic environments entail: changes in parameter over time and changes in the observed dimension. We formulate the model with framework of a state space model. We realize an estimation of the model using modified Kalman filter/fixed interval smoother. We find that new product's entry (1) decreases brand differentiation for existing brands, as indicated by decreasing difference between cross-price elasticities; (2) decreases commodity power for existing brands, as indicated by decreasing trend; and (3) decreases the effect of discount for existing brands, as indicated by a decrease in the magnitude of own-brand price elasticities. The proposed framework is directly applicable to other fields in which the observed dimension might be change, such as economic, bioinformatics, and so forth. (shrink)

A 10 kHz pulsed X-ray generator utilising a hot-cathode triode in conjunction with a new type of grid control device for controlling X-ray duration is described. The energy-storage condenser was charged up to 70 kV by a power supply, and the electric charges in the condenser were discharged to the X-ray tube repetitively by the grid control device. The maximum values of the grid voltage, the tube voltage, and the tube current were −1.5 kV, 70 kV, and 0.4 A, respectively. (...) The duration of the flash X-ray pulse was primarily determined by the time constant of the grid control device and the cut-off voltage of thermoelectrons. The X-ray duration was controlled within a region of less than 1 ms; the X-ray intensity with a pulse width of 0.27 ms, a charged voltage of 70 kV, and a peak tube current of 0.4 A was 0.92 μC kg −1 at 0.5 m per pulse. The maximum repetition rate was about 10 kHz, and the size of the focal spot was about 3.5×3.5 mm. (shrink)