Correct chromosome segregation in mitosis relies on chromosome biorientation, in which sister kinetochores attach to microtubules from opposite spindle poles prior to segregation. To establish biorientation, aberrant kinetochore–microtubule interactions must be resolved through the error correction process. During error correction, kinetochore–microtubule interactions are exchanged (swapped) if aberrant, but the exchange must stop when biorientation is established. In this article, we discuss recent findings in budding yeast, which have revealed fundamental molecular mechanisms promoting this “swap and stop” process for error correction. (...) Where relevant, we also compare the findings in budding yeast with mechanisms in higher eukaryotes. Evidence suggests that Aurora B kinase differentially regulates kinetochore attachments to the microtubule end and its lateral side and switches relative strength of the two kinetochore–microtubule attachment modes, which drives the exchange of kinetochore–microtubule interactions to resolve aberrant interactions. However, Aurora B kinase, recruited to centromeres and inner kinetochores, cannot reach its targets at kinetochore–microtubule interface when tension causes kinetochore stretching, which stops the kinetochore–microtubule exchange once biorientation is established. (shrink)

Since the realisation that the antigen‐binding regions of antibodies, the variable (V) regions, can be uncoupled from the rest of the molecule to create fragments that recognise and abrogate particular protein functions in cells, the use of antibody fragments inside cells has become an important tool in bioscience. Diverse libraries of antibody fragments plus in vivo screening can be used to isolate single chain variable fragments comprising VH and VL segments or single V‐region domains. Some of these are interfering antibody (...) fragments that compete with protein‐protein interactions, providing lead molecules for drug interactions that until now have been considered difficult or undruggable. It may be possible to deliver or express antibody fragments in target cells as macrodrugs per se. In future incarnations of intracellular antibodies, however, the structural information of the interaction interface of target and antibody fragment should facilitate development of binding site mimics as small drug‐like molecules. This is a new dawn for intracellular antibody fragments both as macrodrugs and as precursors of drugs to treat human diseases and should finally lead to the removal of the epithet of the ‘undruggable’ protein‐protein interactions. (shrink)

In this paper, illocutionary acts of commanding will be differentiated from perlocutionary acts that affect preferences of addressees in a new dynamic logic which combines the preference upgrade introduced in DEUL (dynamic epistemic upgrade logic) by van Benthem and Liu with the deontic update introduced in ECL II (eliminative command logic II) by Yamada. The resulting logic will incorporate J. L. Austin’s distinction between illocutionary acts as acts having mere conventional effects and perlocutionary acts as acts having real effects upon (...) attitudes and actions of agents, and help us understand why saying so can make it so in explicit performative utterances. We will also discuss how acts of commanding give rise to so-called “deontic dilemmas” and how we can accommodate most deontic dilemmas without triggering so-called “deontic explosion”. (shrink)

Kripke completeness of some infinitary predicate modal logics is presented. More precisely, we prove that if a normal modal logic above is -persistent and universal, the infinitary and predicate extension of with BF and BF is Kripke complete, where BF and BF denote the formulas pi pi and x x, respectively. The results include the completeness of extensions of standard modal logics such as , and its extensions by the schemata T, B, 4, 5, D, and their combinations. The proof (...) is obtained by extending the correspondence between the representation of modal algebras and the completeness of propositional modal logic to infinite. (shrink)

Although it seems intuitively clear that acts of requesting are different from acts of commanding, it is not very easy to sate their differences precisely in dynamic terms. In this paper we show that it becomes possible to characterize, at least partially, the effects of acts of requesting and compare them with the effects of acts of commanding by combining dynamified deontic logic with epistemic logic. One interesting result is the following: each act of requesting is appropriately differentiated from an (...) act of commanding with the same content, but for each act of requesting, there is another act of commanding with much more complex content which updates models in exactly the same way as it does. We will also consider an application of our characterization of acts of requesting to acts of asking yes-no questions. It yields a straightforward formalization of the view of acts of asking questions as requests for information. (shrink)

In one of his key texts, the Mūlamadhyamakakārikā, Nāgārjuna famously sets out to refute the ontology of essence.1 He presents numerous arguments to show that things don’t exist essentially—that is, that things are empty of essence or inherent existence. The doctrine of emptiness has been variously understood by traditional and contemporary commentators. Most radical is the recent interpretation presented by Garfield and Priest. They have rationally reconstructed Nāgārjuna’s doctrine of emptiness as an endorsement of the contradictory nature of reality. According (...) to them, Nāgārjuna can be seen to be arguing that the way in which things exist in reality and what we can truly say about them must be... (shrink)

SOCREAL 2013 : 3rd International Workshop on Philosophy and Ethics of Social Reality 2013. Hokkaido University, Sapporo, Japan, 25-27 October 2013. Session 4 : Agency, Responsibility, and Intentionality.

SOCREAL 2010: 2nd International Workshop on Philosophy and Ethics of Social Reality. Sapporo, Japan, 2010-03-27/28. Keynote Lecture 3.

In this paper, we establish the first-order definability of sequents with consistent variable occurrence on bi-approximation semantics by means of the Sahlqvist–van Benthem algorithm. Then together with the canonicity results in Suzuki (2011), this allows us to establish a Sahlqvist theorem for substructural logic. Our result is not limited to substructural logic but is also easily applicable to other lattice-based logics.

In this paper, we extend the canonicity methodology in Ghilardi & Meloni (1997) to arbitrary lattice expansions, and syntactically describe canonical inequalities for lattice expansions consisting of -meet preserving operations, -multiplicative operations, adjoint pairs, and constants. This approach gives us a uniform account of canonicity for substructural and lattice-based logics. Our method not only covers existing results, but also systematically accounts for many canonical inequalities containing nonsmooth additive and multiplicative uniform operations. Furthermore, we compare our technique with the approach in (...) Dunn et al. (2005) and Gehrke et al. (2005). (shrink)

In this paper, we give a possible characterization of the distributivity on bi-approximation semantics. To this end, we introduce new notions of special elements on polarities and show that the distributivity is first-order definable on bi-approximation semantics. In addition, we investigate the dual representation of those structures and compare them with bi-approximation semantics for intuitionistic logic. We also discuss that two different methods to validate the distributivity—by the splitters and by the adjointness—can be explicated with the help of the axiom (...) of choice as well. (shrink)

Nursing students face various ethical issues, which may cause stress, that require coping strategies. This study investigated the thoughts and feelings underlying the coping behaviors adopted by nursing students when addressing ethical issues. Semi-structured interviews were conducted from September to October 2011 with 11 students enrolled at University A who had completed basic nursing and specialty practicums and consented to participate in the study. Data were analyzed using qualitative methods. The participant narratives about ethical issues encountered during clinical practicums were (...) organized into four themes and 20 scenarios. The ethical issues concerned the attitudes and conduct of nurses, doctors, physical therapists, and other medical professionals. Seven coping behaviors were identified. The results revealed that nursing students waver between valuing their relationships with nurses and their relationships with patients when they encounter an ethical issue. When their relationships with nurses were emphasized, their ethical values were restructured. These findings suggest the need to address the affective domain early on in lectures and in-class practice, and to create an environment in which students taking practicums can easily express their feelings and internal value system changes. (shrink)

In the past four decades, the notion of quantum polynomial-time computability has been mathematically modeled by quantum Turing machines as well as quantum circuits. This paper seeks the third model, which is a quantum analogue of the schematic definition of recursive functions. For quantum functions mapping finite-dimensional Hilbert spaces to themselves, we present such a schematic definition, composed of a small set of initial quantum functions and a few construction rules that dictate how to build a new quantum function from (...) the existing ones. We prove that our schematic definition precisely characterizes all functions that can be computable with high success probabilities on well-formed quantum Turing machines in polynomial time, or equivalently uniform families of polynomial-size quantum circuits. Our new, schematic definition is quite simple and intuitive and, more importantly, it avoids the cumbersome introduction of the well-formedness condition imposed on a quantum Turing machine model as well as of the uniformity condition necessary for a quantum circuit model. Our new approach can further open a door to the descriptional complexity of quantum functions, to the theory of higher-type quantum functionals, to the development of new first-order theories for quantum computing, and to the designing of programming languages for real-life quantum computer. (shrink)

SOCREAL 2007: International Workshop on Philosophy and Ethics of Social Reality. Sapporo, Japan, 2007-03-09/10. Session 2: Logical Dynamics of Social Interaction.

If the notion of speech acts is to be taken seriously, it must be possible to treat speech acts as acts. The development of systems of DEL (dynamic epistemic logic) in the last two decades suggests an interesting possibility. These systems are developed on the basis of static epistemic logics by introducing model updating operations to interpret various kinds of speech acts including public announcements as well as private information transmissions as what update epistemic states of agents involved. The methods (...) used in developing DEL can be used to develop logics that deal with a much wider variety of speech acts. For example, in ECL (Eliminative Command Logic) of Yamada (2007a) and ECL II of Yamada (2007b), similar model updating operations are introduced tointerpret acts of commanding as what update deontic aspects of the situations in which agents are involved. In Yamada (2008a), ECL II is further extended so as to model acts of promising along with acts of commanding. Moreover, in Yamada (2008b), ECL II is combined with a modified version of DEUL (dynamic epistemic upgrade logic) introduced in van Benthem & Liu (2007). In the resulting logic DDPL (dynamic deontic preference logic), illocutionary acts of commanding are differentiated from preference upgrading perlocutionary acts. The development of these logics suggests a recipe for developing logics that deal with various specific speech acts: first, carefully identify the aspects affected by the speech acts you want to study; second, find the modal logic that characterizes the aspects in question; and finally, add dynamic modalities that stand for the types of the speech acts being studied and define model updating operation that interprets these speech acts as what update the very aspects. (shrink)

Two-player, zero-sum, non-cooperative, blindfold games in extensive form with incomplete information are considered in this paper. Any information about past moves which players played is stored in a database, and each player can access the database. A polynomial game is a game in which, at each step, all players withdraw at most a polynomial amount of previous information from the database. We show resource-bounded determinacy of some kinds of finite, zero-sum, polynomial games whose pay-off sets are computable by non-deterministic polynomial-time (...) function-oracle Turing machines. We call a pay-off set -determined if, for any polynomial game G associated with the given pay-off set, either player has a winning strategy which is in for any subgames of G. We show that there exists an FP-strongly-determined pay-off set which is computed by an exponential-time oracle Turing machine, where FP is the set of polynomial-time computable functions. We also discuss several relationships between the determinacy of polynomial games and recursion-theoretic properties for the classes co-NP and co-NEXP. We show that the polynomial version of the axiom of choice holds under some assumption of polynomial determinacy for a pay-off set which is polynomial-time computable with parallel queries. This principle of choice implies that co-NP has the separation property. (shrink)

An assessment of mood or emotion is important in developing mental health measures, and facial expressions are strongly related to mood or emotion. This study thus aimed to examine the relationship between levels of negative mood and characteristics of mouth parts when moods are drawn as facial expressions on a common platform. A cross-sectional study of Japanese college freshmen was conducted, and 1,068 valid responses were analyzed. The questionnaire survey consisted of participants’ characteristics, the Profile of Mood States, and a (...) sheet of facial expression drawing, and the sheet was digitized and analyzed using an image-analysis software. Based on the total POMS score as an index of negative mood, the participants were divided into four groups: low, normal, high, and very high. Lengths of drawn lines and between both mouth corners were significantly longer, and circularity and roundness were significantly higher in the L group. With increasing levels of negative mood, significant decreasing trends were observed in these lengths. Convex downward and enclosed figures were significantly predominant in the L group, while convex upward figures were significantly predominant and a tendency toward predominance of no drawn mouths or line figures was found in the H and VH groups. Our results suggest that mood states can be significantly related to the size and figure characteristics of drawn mouths of FACED on a non-verbal common platform. That is, these findings mean that subjects with low negative mood may draw a greater and rounder mouth and figures that may be enclosed and downward convex, while subjects with a high negative mood may not draw the line, or if any, may draw the line shorter and upward convex. (shrink)

Graphical AbstractEnvironmental oxygen might have been the key for the evolution of novel developmental mechanisms, such as the interdigital cell death of amniotes. Increased amount of oxygen can also induce cell death in interdigital regions of an amphibian that typically lacks it. To learn more about the role of environmental oxygen in the evolution of new traits, see the article number 2000025 by Ingrid Rosenburg Cordeiro and Mikiko Tanaka. Cover image by Itoko Tanaka and Mikiko Tanaka.

A logic is called 'paraconsistent' if it rejects the rule called 'ex contradictione quodlibet', according to which any conclusion follows from inconsistent premises. While logicians have proposed many technically developed paraconsistent logical systems and contemporary philosophers like Graham Priest have advanced the view that some contradictions can be true, and advocated a paraconsistent logic to deal with them, until recent times these systems have been little understood by philosophers. This book presents a comprehensive overview on paraconsistent logical systems to change (...) this situation. The book includes almost every major author currently working in the field. The papers are on the cutting edge of the literature some of which discuss current debates and others present important new ideas. The editors have avoided papers about technical details of paraconsistent logic, but instead concentrated upon works that discuss more 'big picture' ideas. Different treatments of paradoxes takes centre stage in many of the papers, but also there are several papers on how to interpret paraconistent logic and some on how it can be applied to philosophy of mathematics, the philosophy of language, and metaphysics. (shrink)

My life as a quantum physicist / M. Nakahara -- A review on operator quantum error correction - Dedicated to Professor Mikio Nakahara on the occasion of his 60th birthday / C.-K. Li, Y.-T. Poon and N.-S. Sze -- Implementing measurement operators in linear optical and solid-state qubits / Y. Ota, S. Ashhab and F. Nori -- Fast and accurate simulation of quantum computing by multi-precision MPS: Recent development / A. Saitoh -- Entanglement properties of a quantum lattice-gas model on (...) square and triangular ladders / S. Tanaka, R. Tamura and H. Katsura -- On signal amplification from weak-value amplification / Y. Shikano -- Topological protection of quantum information / K. Fujii -- Quantum annealing with antiferromagnetic fluctuations for mean-field models / Y. Seki and H. Nishimori -- A method to change phase transition nature - Toward annealing methods / R. Tamura and S. Tanaka -- Computational analysis of the first stage of the photosynthetic system, the light-dependent reaction, by quantum chemical simulation method / M. Tada-Umezaki -- Two-qubit gate operation on selected nearest neighboring qubits in a neutral atom quantum computer / E. Hosseini Lapasar... [et al.] -- A simple operator quantum error correction scheme avoiding fully correlated errors / C. Bagnasco, Y. Kondo and M. Nakahara -- Black hole predictability, classical and quantum / A. Ishibashi -- Classical field simulation of finite-temperature Bose gases / T. Sato -- Atomic quantum simulations of lattice gauge theory: Effect of gauge symmetry breaking / K. Kasamatsu, I. Ichinose and T. Matsui -- Recursive construction of noiseless subsystem for qudits / U. Gungordu... [et al.] -- Composite quantum gates for precise quantum control / M. Bando... [et al.] -- New formulation of statistical mechanics using thermal pure quantum states / S. Sugiura and A. Shimizu -- Thermodynamics in unitary time evolution / T. N. Ikeda -- Second law of thermodynamics with QC-mutual information / T. Sagawa. (shrink)

Following on from Shaun Gallagher's influential 2005 book How the Body Shapes the Mind, this volume brings together leading experts from the fields of philosophy, neuroscience, psychology, and psychiatry in a productive dialogue, exploring key questions and debates about the relationship between body schema and body image.