PurposeTo use the power of knowledge acquisition and machine learning in the development of a collaborative computer classification system based on the features of age-related macular degeneration (AMD).MethodsA vocabulary was acquired from four AMD experts who examined 100 ophthalmoscopic images. The vocabulary was analyzed, hierarchically structured, and incorporated into a collaborative computer classification system called IDOCS. Using this system, three of the experts examined images from a second set of digital images compiled from more than 1000 patients with AMD. Images (...) were annotated, and features were identified and defined. Decision trees, a machine learning method, were trained on the data collected and used to extract patterns. Interrelationships between the data from the different clinicians were investigated.ResultsSix drusen classes in the structured vocabulary were largely sufficient to describe all the identified features. The decision trees classified the data with 76.86% to 88.5% accuracy and distilled patterns in the form of hierarchical trees composed of 5 to 15 nodes. Experts were largely consistent in their characterization of soft, and to a lesser extent, hard drusen, but diverge in definition of other drusen. Size and crystalline morphology were the main determinants of drusen type across all experts.ConclusionsMachine learning is a powerful tool for the characterization of disease phenotypes. The creation of a defined feature set for AMD will facilitate the development of an IDOCS-based classification system. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Math Anxiety:Making Room to BreatheValerie Allen (bio) and Todd Stambaugh (bio)"Don't do that to me, Professor," the student said, and everybody laughed, for by this late in the semester, the atmosphere was relaxed. The instructor in question had just reached the point in a worked problem when they could move from reasoning about specific numbers to stating a general principle: x≤y≤z, meaning that y—the value we sought—was always (...) going to be greater than or equal to one value (x) and less than or equal to the other (z). The student who had spoken had earned everyone's affection over the weeks, open about their difficulties with math, ready to risk being wrong, and to ask obvious questions that others may have been reluctant to owning. They had hung in there, despite presenting a classic case of math anxiety, a syndrome long recognized in the scholarship of teaching and learning.Among math anxiety's many symptoms, breathing disruption ranks high: hyperventilation (rapid breathing) and hypoventilation (barely or not breathing). When the energy-conserving parasympathetic nervous system is overtaken by the energy-expending sympathetic nervous system, the long exhalations that decelerate the heart rate are replaced by short, panting puffs from the upper lungs. The timed test provides the perfect environment for math anxiety to flourish. Stress diverts cognitive resources needed for procedural execution, so working memory consequently shrinks.Self-rated metrics for math anxiety have been in place for decades (Richardson and Suinn). Relatively trivial interventions can yield nontrivial results: deep breathing exercises and positive affirmations have a beneficial impact, as does writing about one's nerves immediately prior to an exam (Brunyé et al.). More systemic changes require a reorientation in teaching whereby conceptual mistakes are positively rewarded as opportunities for learning; students compose questions instead of answers; students solve problems together rather than perform solo (Boaler).Return now to that opening scenario to watch it become stereotype incarnate: the student was mature, Black, and female; the teacher, younger, white, and male; her comment was triggered by his shift from a specific [End Page 217] set of numbers into symbolic notation. There is robust evidence to demonstrate that certain demographics are consistently underrepresented in the U.S. math community: women and "African-Americans, Hispanics, American Indians, Alaska Natives, and Pacific Islanders," according to the Mathematical Association of America (MAA) ("Resources for Minority"). Routinely feeling that they do not belong, such groups are particularly vulnerable to math anxiety.Several remedies for such disparity suggest themselves: appointing more women and people of color in the profession; one-on-one tutorial assistance; research projects about the students' personal environment; privileging pre-test, low-stakes work over timed tests; assigning group rather than individual work. When all is said and done, however, such strategies "have little to do with mathematics content" (Martin 304). Mathematicians still need to be able to conceptualize, describe, and manipulate abstract objects, and there seems to be a suspicion that, at heart, abstraction is gendered masculine and colored white.It is possible that the rhetorical immediacy and context-dependence of Black English has misguidedly reinforced such a perception. For poet June Jordan, Black English "devolves from a culture that abhors all abstraction" (Jordan 367). Psychiatrist Alvin Poussaint asks, "Is there a way to say metamorphosis in Ebonics?" (O'Malley). Yet, despite Black English's avoidance of nominalization and similar verbosities that afflict academic prose, abstract logical reasoning flourishes in vernacular idiom, as linguist William Labov demonstrated half a century ago. Our aim is not to explain the asymptote in Black English but rather to consider a feature characteristic of those very minority cultures historically underrepresented in math—storytelling—and to ask how it may be foregrounded in mathematics, where it is decisively sidelined. Storytelling has been claimed by every culture and ethnic group at some point as the repository of wisdom, practical skills, religious beliefs, and shared identity and values; but when it gets corralled into the category of "fiction," and when it gets opposed to "fact," a narrowed concept of truth dispatches storytelling to kindergarten and recreational math. Word problems may supply scenarios but offer none of a plot's satisfactions... (shrink)

On Virgil's statement that in honour of Bacchus ‘Ausonii … coloni versibus incomptis ludunt’, Servius remarks: ‘id est, carminibus Saturnio metro compositis, quod ad rhythmum solum vulgares componere consuerunt….’Obviously Servius is drawing a distinction between the Saturnian and other metres, as well as between the ordinary man and the man of letters. The unlettered compose their verses in the Saturnian metre, which is founded on rhythmus alone; the literary circles write theirs on some other basis.

‘A foolish consistency is the hobgoblin’ not only ‘of little minds,’ but of some classically trained minds as well. And it is surprising to see how this has caused certain unevennesses in ancient authors to be trued up. Aristophanes, for example, we are toldby a late venerable scholar, never permits a change of meter in a single speech directed to the same person; and to get rid of the two deviations from this rule, the framer of it cut down the (...) seemingly good trochaic tetrameters in the Peace to iambic trimeters, and then put line 555 before line 553 and took the three lines 555, 553, 554 from Trygaeus and assigned them to the coryphaeus. It is conceivable that if we possessed the thirty-three lost comedies of Aristophanes the editor might have had more and harder surgery on his hands. (shrink)

‘Saepe stilum vertas’, says Horace; and he had excellent company in his friend Virgil, who wrote the Aeneid at the rate of only about 900 lines a year, and spent hours in licking his verses into shape. It would have been instructive to sit at the elbow of these two poets, to see what they altered and what they rejected. It is clear, e.g., that there were certain caesural arrangements which Virgil deliberately affected and others which he as deliberately avoided. (...) But what of the care taken by these and other classical authors in arranging sounds in relation to mood or idea? This present incomplete essay is written frankly with scepticism in regard to dogmatic comments on certain particular points. It has been perilously easy to frame legislation on the basis of a predilection bolstered up by one or two instances. Even in the field of syntax we have seen generalizations on too narrow a foundation. An editor of Andocides enunciates ‘a very important principle of the language, which is rigidly observed by the best writers; viz., that, when a participle and a verb of different government are referred to the same object, the case of that object depends on the participle and not at all on the verb… Shilleto's remarks on this point must be excused, as evidently written hastily.’ But a casual cast of the net brings up about a score of violations of this principle from Homer to Menander. Where does the editor propose to draw the line between the respectable and the declassé Greek writers? Aristophanes, though cited in support, is actually flagrantly lawless in the matter; and with him must go not only Homer and Hyperides but Sophocles, Euripides, Menander, Xenophon, Lysias, and Plato, leaving among the élite, as cited by this editor, only Thucydides, Antiphon, and Aeschines; and one is entitled to doubt even their rigid observance of the law until they have actually been brought to court. In problems of rhythm, also, one has to be careful to use evidence as against preconception. When an editor hacks and fits the dactylics of Ennius so as to eradicate all feet beginning with two short syllables, it is as impious as recarving a statue by Daedalus because it does not conform to the canon of Polyclitus; and one may be forgiven if now and then one interprets the editor's corr. in his apparatus criticus not as correxi but as corrupi. (shrink)

Herodotus tells us in book vii, ch. 220, that the Pythian priestess gave the Spartans a warning couched in hexameters, of which the second line begins ἢ μγα στυ ρικυδς. To this text the admirable commentary of How and Wells takes exception in the following note: ‘The synizesis στυ ρικυδς is intolerable. Read δμ' ρικυδς, στυ being a gloss, H. Richards, Cl. Rev. xix. 345.’ Doubtless this union of vowels is harder than that of υω in ρινων or in γενων (...) and δυωδεκμηνον, accepted by Christ in his edition of Pindar . Let us grant that from the point of view of elegance it is even intolerable; the question still remains, should the line be altered? (shrink)

When Demosthenes brought Aeschines to trial on a charge of malfeasance as an ambassador, he made what seems now the astonishing declaration in connection with Aeschines' acting of the part of Creon in Sophocles' Antigone: ⋯στε γ⋯ρ δ⋯που το⋯θ' ὅτι ⋯ν ἅπασι τοῖς δρ⋯μασι τοῖς τραγικοῖς ⋯ξα⋯ρετ⋯ν ⋯στιν ὥσπερ γ⋯ρας τοῖς τριταγωνισ ταῖς τὺ τοὺς τυρ⋯ννους κα⋯ τοὺς τ⋯ σκ⋯πτρ' ἔχοντας εἰσι⋯ναι. Until the last generation this was taken at face value as indicating that of the three actors presenting a (...) tragedy the third was regularly assigned the part of royalty. But that the title rôle in such plays as Sophocles' Oedipus Tyrannus or an important character such as Creon in the Antigone should have been entrusted to the third ranking actor is incredible. How is the discrepancy to be explained? (shrink)

The purpose of this study was to assess the presence of ethics committees in rural critical access hospitals across the United States. Several studies have investigated the presence of ethics committees in rural health care facilities. The limitation of these studies is in the definition of ‘rural hospital’ and a regional or state focus. These limitations have created large variations in the study findings. In this nation-wide study we used the criteria of a critical access hospital (CAH), as defined by (...) the Medicare Rural Hospital Flexibility Program (Flex Program, 2007), to bring consistency and clarity to the assessment of the presence of ethics committees in rural hospitals. The Flex Monitoring Team conducted a national telephone survey of 381 CAH administrators throughout the United States. The survey covered a wide variety of questions concerning hospitals’ community benefit, impact activities, and whether the hospital had a formally established an ethics committee. About 230 (60%) of the respondents indicated they had a formally established ethics committee or ethics consultation program at their CAH. The prevalence of ethics committees declined as the CAH location became increasingly rural along a rural–urban continuum. Unlike CAHs, all rural Department of Veterans Affairs Medical Centers have ethics committees. The results of this study provide an understanding of the limited presence of ethics committee in rural America and the need to consider new approaches for providing ethics assistance. A virtual ethics committee network may be the most efficient and effective way of providing rural hospitals access to a knowledgeable ethics committee or consultant. (shrink)

We know that microbes contribute to the production of odors that some animals use to communicate, but how common is this phenomenon? Recent studies capitalizing on new molecular technologies are uncovering fascinating associations between microbes and odors of wild animals, but causality is difficult to ascertain. Fundamental questions about the nature of these unique host‐microbe interactions also remain unanswered. For instance, do microbes benefit from signaling associations with hosts? How does microbial community structure influence signal production? How do hosts regulate (...) microbes in order to generate appropriate signals? Here, we review the current state of knowledge on microbially produced signals in animals and discuss key research foci that can advance our understanding of microbial‐based signaling in the animal world. (shrink)

Many bacteria conditionally express proteinaceous organelles referred to here as microcompartments (Fig. 1). These microcompartments are thought to be involved in a least seven different metabolic processes and the number is growing. Microcompartments are very large and structurally sophisticated. They are usually about 100–150 nm in cross section and consist of 10,000–20,000 polypeptides of 10–20 types. Their unifying feature is a solid shell constructed from proteins having bacterial microcompartment (BMC) domains. In the examples that have been studied, the microcompartment shell (...) encases sequentially acting metabolic enzymes that catalyze a reaction sequence having a toxic or volatile intermediate product. It is thought that the shell of the microcompartment confines such intermediates, thereby enhancing metabolic efficiency and/or protecting cytoplasmic components. Mechanistically, however, this creates a paradox. How do microcompartments allow enzyme substrates, products and cofactors to pass while confining metabolic intermediates in the absence of a selectively permeable membrane? We suggest that the answer to this paradox may have broad implications with respect to our understanding of the fundamental properties of biological protein sheets including microcompartment shells, S‐layers and viral capsids. BioEssays 30:1084–1095, 2008. © 2008 Wiley Periodicals, Inc. (shrink)

In this paper it is claimed that beliefs, feelings, and actions are typically complex phenomena which have simpler components. In particular, beliefs often involve feelings and actions, while actions involve feelings and beliefs, and feelings involve beliefs and actions. It is then suggested that unconscious beliefs and commitments, both ontological and otherwise, may be discovered by the examination of actions and feelings. While these will vary from one individual to another, it is suggested that it may be possible to form (...) certain generalizations which are of philosophical interest. (shrink)

There are two basically different sorts of theory of meaning and the sort of theory one adopts has a great deal to do with the view one takes of the learning of language. Corresponding to the two kinds of theory of meaning two theories of the learning of language are delineated and the issues that are disputed by them clarified. The logical question of whether each theory is intelligible in itself is first discussed, and, it being concluded that both are (...) genuine empirical hypotheses, an examination is made of psychological grounds for preferring one or the other. While no final decision is arrived at, it is argued that there are grounds for preferring one of the theories. (shrink)

The impact of Stoicism on Roman culture and early Christianity was considerable. Unfortunately, little survives of the early writings on Stoicism. Our knowledge of it comes largely from a few later Stoics. In this unique book, William O. Stephens explores the moral philosophy of the late Stoic Epictetus, a former slave and dynamic Stoic teacher. His philosophy, as recorded by one of his students, is the most earnest and most compelling defense of ancient Stoicism that exists. Epictetus' teachings dramatically capture (...) the optimistic spirit of Stoicism by examining our greatest human challenges, such as the death of a loved one. Stephens shows how, for Epictetus, happiness results from concerning ourselves with what is up to us while not worrying about what is beyond our control. He concludes that the strength of Epictetus' philosophy lies in his conception of happiness as freedom from anger, fear, worry, grief, and dependence upon luck. (shrink)

This book is a clear and concise introduction to the Roman Emperor Marcus Aurelius Antoninus. His one major surviving work, often titled 'meditations' but literally translated simply as 'to himself', is a series of short, sometimes enigmatic reflections divided seemingly arbitrarily into twelve books and apparently written only to be read by him. For these reasons Marcus is a particularly difficult thinker to understand. His musings, framed as 'notes to self' or 'memoranda', are the exhortations of an earnest, conscientious Stoic (...) burdened with the onerous responsibilities of ruling an entire, enormous empire. William O. Stephens lucidly sketches Marcus Aurelius' upbringing, family relations, rise to the throne, military campaigns, and legacy, situating his philosophy amidst his life and times, explicating the factors shaping Marcus' philosophy, and clarifying key themes in the Memoranda. Specifically designed to meet the needs of students seeking a thorough understanding of this key figure and his major work, Marcus Aurelius: A Guide for the Perplexed is the ideal guide for understanding this Stoic author - the only philosopher who was also an emperor. (shrink)

Alterations to cognitive function are often reported with depression and anxiety symptoms, yet few studies have examined the same associations with mental well-being. This study examined the association between mental well-being, depression and anxiety symptoms and cognitive function in 1502 healthy adult monozygotic and dizygotic twins, and the shared/unique contribution of genetic and environmental variance. Using linear mixed models, mental well-being was positively associated with sustained attention, inhibition, cognitive flexibility, motor coordination and working memory, whereas depression and anxiety symptoms were (...) associated with poorer sustained attention, inhibition, cognitive flexibility and executive function. Bivariate twin modelling showed well-being shared a small environmental correlation with motor coordination and a small genetic correlation with working memory. Trivariate twin modelling showed well-being shared a small genetic correlation with inhibition, whereas depression and anxiety symptoms shared a small environmental correlation with inhibition. The remaining variance was mostly driven by unique G and/or E variance. Overall, well-being and depression and anxiety symptoms show both independent and shared relationships with cognitive functions but this is largely attributable to unique G or E variance and small shared G/E variance between pairs of variables. (shrink)

In this paper I will argue that Professor Goodman was correct in thinking that there is a problem concerning counterfactual conditionals, but that it is somewhat different from the problem he thought it to be, and is one that is even more basic. I will also try to show that this problem is distinct from Hume's "problem" of induction, and that additional assumptions have to be made for counterfactual induction beyond those required for other kinds of induction.

This essay discusses engineering ethics in Puerto Rico by examining the impact of the Colegio de Ingenieros y Agrimensores de Puerto Rico (CIAPR) and by outlining the constellation of problems and issues identified in workshops and retreats held with Puerto Rican engineers. Three cases developed and discussed in these workshops will help outline movements in engineering ethics beyond the compliance perspective of the CIAPR. These include the Town Z case, Copper Mining in Puerto Rico, and a hypothetical case researched by (...) UPRM students on laptop disposal. The last section outlines four future challenges in engineering ethics pertinent to the Puerto Rican situation. (shrink)

The vitally important concept of the "person" is featured in this anthology of readings from the history of Western philosophy. This text which is philosophically more serious yet still reader-friendly, offers a variety of authors and a wide historical scope in the Philosophy of Human Nature market that generally neglects this topic.

It is suggested that there is a strong connection between intentions and plans, and these plans are then taken to be programs of the sort suggested by Miller, Galanter, and Pribram in Plans and the Structure of Behavior. There is then a hierarchy of programs connected with intentions stretching from the macroscopic level of ordinary discourse to the neurological level. It is argued that as we proceed downwards we arrive at a threshold below which we can still describe the phenomena (...) but below which we can no longer speak of intentions. The paper concludes with a discussion of the criteria for the identity of intentions at various levels. (shrink)

A discussion of egoism and altruism as related both to ethical theory and moral psychology. Williams considers and rejects various arguments for and against the existence of egoistic motives and the rationality of someone motivated by self-interest. He ultimately attempts to give a more Humean defense of altruism, as opposed to the more Kantian defenses found in Thomas Nagel, for example.

Philosophers usually have been anxious to avoid solipsism. A large number of good and great philosophers have tried to refute it. Of course, these philosophers have not always had the same target in mind and, like everything else, solipsism over the centuries has become increasingly elusive and subtle. In this book I undertake to state the position in its most modern and what I take to be its most plausible form. At some points in the history of philosophy the solipsist (...) has been one who denied the existence of everything except himself or even the existence of everything except his own present sensations. At other times, the solipsist instead of doubting these things has merely insisted that there could be no good reason for believing in the existence of anything beyond one's own present sensations. Roughly, this doubt is aimed at reasons rather than at things. A solipsist of this sort appears in Santayana's Scepticism and Animal Faith. (shrink)