A large body of evidence on the activity of regulatory T (Treg) cells was gathered during the last decade, and a similar number of reviews and opinion papers attempted to integrate the experimental findings. The abundant literature clearly delineates an exciting area of research but also underlines some major controversies. A linear cause–result interpretation of experimental maneuvers often ignores the fact that the activity of Treg cells is orchestrated with the effector T (Teff) cells within an intricate network of physiological (...) immune homeostasis. Every modulation of the activity of the effector (cytotoxic) immune system revolves to affect the activity of regulatory (suppressive) cells through elaborate feedback loops of negative and positive regulation. The lack of IL‐2 production by innate Treg cells makes this cytokine a prime coupler of the effector and suppressive mechanisms. Here we attempt to integrate evidence that delineates the involvement of IL‐2 in primary and secondary feedback loops that regulate the activity of suppressive cells within the elaborate network of physiological immune homeostasis.©2007 Wiley Periodicals, Inc BioEssays 30:875–888, 2008. © 2008 Wiley Periodicals, Inc. (shrink)

Yarkoni argues that researchers making broad inferences often use impoverished statistical models that fail to include important sources of variation as random effects. We argue, however, that for many common study designs, random effects are inappropriate and insufficient to draw general inferences, as the source of variation is not random, but systematic.

The most plausible of Yarkoni's paths to recovery for psychology is the least radical one: psychologists need truly quantitative methods that exploit the informational power of variance and heterogeneity in multiple variables. If they drop ambitions to explain entire behaviors, they could find a box full of design and econometric tools in the parts of experimental economics that don't ape psychology.

Arabic language; grammar; syntax; linguistics.

To compare a novel to a work of philosophy is, admittedly, a risky exercise in analogy. When the novelist is Lawrence and the philosophical text is the ponderous and dialectical Being and Nothingness, such a comparison may seem willfully perverse and peculiarly open, insofar as it deals with Lawrence's great theme of sexuality, to his anathema of "sex in the head." Furthermore, modern criticism, especially in the Anglo-Saxon world, has tended to be wary of critical approaches that lean on notions (...) that are not derived from literature itself - a tendency that is being reinforced these days by the structuralist insistence on the "literariness" of the Text. Now, despite its metaphorical statement as a form of dramatic "gesture," Sartre's book is very definitely not a work of literature. T.H. Adamowski, associate professor of English at Erindale College, the University of Toronto, has written articles on English, American, and French literature. This essay is part of a larger study on progress on Lawrence's "sexual poetics.". (shrink)

Reality medical television, an increasingly popular genre, depicts private medical moments between patients and healthcare providers. Journalists aim to educate and inform the public, while the participants in their documentaries—providers and patients—seek to heal and be healed. When journalists and healthcare providers work together at the bedside, moral problems precipitate. During the summer of 2010, ABC aired a documentary, Boston Med, featuring several Boston hospitals. We examine the ethical issues that arise when journalism and medicine intersect. We provide a framework (...) for evaluating the potential benefits and harms of reality medical television, highlighting critical issues such as informed consent, confidentiality, and privacy. (shrink)

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The complex spectral representation of the Liouville operator introduced by Prigogine and others is applied to moderately dense gases interacting through hard-core potentials in arbitrary d-dimensional spaces. Kinetic equations near equilibrium are constructed in each subspace as introduced in the spectral decomposition for collective, renormalized reduced distribution functions. Our renormalization is a nonequilibrium effect, as the renormalization effect disappears at equilibrium. It is remarkable that our renormalized functions strictly obey well-defined Markovian kinetic equations for all d, even though the ordinary (...) distribution functions obey nonMarkovian equations with memory effects. One can now define transport coefficients associated to the collective modes for all dimensional systems including d = 2. Our formulation hence provides a microscopic meaning of the macroscopic transport theory. Moreover, this gives an answer to the long-standing question whether or not transport equations exist in two-dimensional systems. The non-Markovian effects for the ordinary distribution function, such as the long-time tails for arbitrary n-mode coupling, are estimated by superposition of the Markovian evolutions of the dressed distribution functions. (shrink)