The exact process that leads to the eruption of autoimmune reactions against β cells and the evolution of diabetes is not fully understood. Macrophages and T cells may launch an initial immune reaction against the pancreatic islets of Langerhans, provoking inflammation and destructive insulitis. The information on the molecular mechanisms of the emergence of β cell injury is controversial and points to possibly important roles for the perforin–granzyme, Fas–Fas-ligand (FasL) and tumor-necrosis-factor-mediated apoptotic pathways. FasL has several unique features that make (...) it a potentially ideal immunomodulatory tool. Most important, FasL is selectively toxic to cytotoxic T cells and less harmful to regulatory T cells. This review discusses the intrinsic sensitivity of β cells to FasL-mediated apoptosis, the conditions that underlie this β cell sensitivity, and the feasibility of using FasL to arrest autoimmunity and prevent islet allograft rejection. In both the autoimmune and transplant settings, it is imperative to progress from the administration of nonspecific immunosuppressive therapy to the concept of β-cell-specific immunomodulation. FasL evolves as a prime candidate for antigen-specific immunomodulation. BioEssays 28: 211–222, 2006. © 2006 Wiley periodicals, Inc. (shrink)

A large body of evidence on the activity of regulatory T (Treg) cells was gathered during the last decade, and a similar number of reviews and opinion papers attempted to integrate the experimental findings. The abundant literature clearly delineates an exciting area of research but also underlines some major controversies. A linear cause–result interpretation of experimental maneuvers often ignores the fact that the activity of Treg cells is orchestrated with the effector T (Teff) cells within an intricate network of physiological (...) immune homeostasis. Every modulation of the activity of the effector (cytotoxic) immune system revolves to affect the activity of regulatory (suppressive) cells through elaborate feedback loops of negative and positive regulation. The lack of IL‐2 production by innate Treg cells makes this cytokine a prime coupler of the effector and suppressive mechanisms. Here we attempt to integrate evidence that delineates the involvement of IL‐2 in primary and secondary feedback loops that regulate the activity of suppressive cells within the elaborate network of physiological immune homeostasis.©2007 Wiley Periodicals, Inc BioEssays 30:875–888, 2008. © 2008 Wiley Periodicals, Inc. (shrink)

First-ever comprehensive introduction to the major new subject of quantum computing and quantum information.

A foundational idea of evo‐devo is that morphological variation is not isotropic, that is, it does not occur in all directions. Instead, some directions of morphological variation are more likely than others from DNA‐level variation and these largely depend on development. We argue that this evo‐devo perspective should apply not only to morphology but to evolution at all phenotypic levels. At other phenotypic levels there is no development, but there are processes that can be seen, in analogy to development, as (...) constructing the phenotype (e.g., protein folding, learning for behavior, etc.). We argue that to explain the direction of evolution two types of arguments need to be combined: generative arguments about which phenotypic variation arises in each generation and selective arguments about which of it passes to the next generation. We explain how a full consideration of the two types of arguments improves the explanatory power of evolutionary theory. Also see the video abstract here: https://youtu.be/Egbvma_uaKc. (shrink)

People increasingly form beliefs based on information gained from automatically filtered Internet ‎sources such as search engines. However, the workings of such sources are often opaque, preventing ‎subjects from knowing whether the information provided is biased or incomplete. Users’ reliance on ‎Internet technologies whose modes of operation are concealed from them raises serious concerns about ‎the justificatory status of the beliefs they end up forming. Yet it is unclear how to address these concerns ‎within standard theories of knowledge and justification. (...) To shed light on the problem, we introduce a ‎novel conceptual framework that clarifies the relations between justified belief, epistemic responsibility, ‎action, and the technological resources available to a subject. We argue that justified belief is subject to ‎certain epistemic responsibilities that accompany the subject’s particular decision-taking circumstances, ‎and that one typical responsibility is to ascertain, so far as one can, whether the information upon which ‎the judgment will rest is biased or incomplete. What this responsibility comprises is partly determined by ‎the inquiry-enabling technologies available to the subject. We argue that a subject’s beliefs that are ‎formed based on Internet-filtered information are less justified than they would be if she either knew how ‎filtering worked or relied on additional sources, and that the subject may have the epistemic ‎responsibility to take measures to enhance the justificatory status of such beliefs.‎. (shrink)

The present paper shows how one might model Everettian quantum mechanics using hyperfinitely many worlds. A hyperfinite model allows one to consider idealized measurements of observables with continuous-valued spectra where different outcomes are associated with possibly infinitesimal probabilities. One can also prove hyperfinite formulations of Everett’s limiting relative-frequency and randomness properties, theorems he considered central to his formulation of quantum mechanics. Finally, this model provides an intuitive framework in which to consider no-collapse formulations of quantum mechanics more generally.

Una respuesta al debate metafilosófico sobre si hay o no unos criterios regulativos en filosofía cómo área de investigación lo ofrece la denominada filosofía sintética. Dentro de esta posición se propone una forma de abordar toda la filosofía y teorizar en base a diferentes criterios propuestos, que suelen ser generalmente: la claridad semántica, la coherencia interna, la coherencia externa con las ciencias y la fecundidad teórica con otros campos de estudio. Estos criterios de corte naturalista a su vez se ofrecen (...) como debatibles y ampliables a otros criterios. Se razonará la necesidad de demarcar la filosofía, y, poniendo el foco en su metodología, se argumentarán los previos criterios con tal de fomentar la filosofía sintética como marco general de trabajo filosófico riguroso. Esto excluye de la disciplina tanto aquello que no sea filosófico como aquello que intente emular la filosofía sin serlo en verdad, la pseudofilosofía. (shrink)

Conceptual engineering is commonly characterized as the method for assessing and improving our representational devices. Little has been said, however, on how best to construe these representational devices—in other words, on what conceptual engineering should be all about. This paper tackles this problem with a basic strategy: First, by presenting a taxonomy of the different possible subject matters for conceptual engineering; then, by comparatively assessing them and selecting the most conducive one with a view to making conceptual engineering an actionable (...) method, that is, a method that can be applied effectively and consistently to specific case studies. The outcome is that conceptual engineering should be all about concepts on pain of pragmatic inconsistencies otherwise. (shrink)

How to accept a conditional? F. P. Ramsey proposed the following test in (Ramsey 1990).(RT) If A, then B must be accepted with respect to the current epistemic state iff the minimal hypothetical change of it needed to accept A also requires accepting B.

Mechanism realists assert the existence of mechanisms as objective structures in the world, but their exact metaphysical commitments are unclear. We introduce Local Hierarchy Realism (LHR) as a substantive and plausible form of mechanism realism. The limits of LHR reveal a deep tension between two aspects of mechanists’ explanatory strategy. Functional decomposition identifies locally relevant entities and activities, while these same entities and activities are also embedded in a nested hierarchy of levels. In principle, a functional decomposition may identify entities (...) engaging in causal interactions that crosscut the hierarchical structure of composition relations, violating the mechanist’s injunction against interlevel causation. We argue that this possibility is realized in the example of ephaptic coupling, a subsidiary process of neural computation that crosscuts the hierarchy derived from synaptic transmission. These considerations undermine the plausibility of LHR as a general view, yet LHR has the advantages that (i) its metaphysical implications are precisely stateable; (ii) the structure it identifies is not reducible to mere aggregate causation; and (iii) it clearly satisfies intuitive and informal definitions of mechanism. We conclude by assessing the prospects for a form of mechanism realism weaker than LHR that nevertheless satisfies all three of these requirements. (shrink)

We study thorn forking and rosiness in the context of continuous logic. We prove that the Urysohn sphere is rosy (with respect to finitary imaginaries), providing the first example of an essentially continuous unstable theory with a nice notion of independence. In the process, we show that a real rosy theory which has weak elimination of finitary imaginaries is rosy with respect to finitary imaginaries, a fact which is new even for discrete first-order real rosy theories.

Plotinus maintains that there is a single first principle, the One (or the Good), from which all other things derive. He is usually thought to hold this view on the grounds that any other thing’s existence depends on its participation in a paradigm of unity. This paper argues that Plotinus has a further, independent argument for adopting a single first principle, according to which principle pluralism is committed (unacceptably) to attributing good cosmic states of affairs to chance. This argument exhibits (...) similarities to ancient design arguments, but is used to draw the more radical conclusion that there is only one non-derivative existent. (shrink)

An international legal agreement governing the global antimicrobial commons would represent the strongest commitment mechanism for achieving collective action on antimicrobial resistance (AMR). Since AMR has important similarities to climate change—both are common pool resource challenges that require massive, long-term political commitments—the first article in this special issue draws lessons from various climate agreements that could be applicable for developing a grand bargain on AMR. We consider the similarities and differences between the Paris Climate Agreement and current governance structures for (...) AMR, and identify the merits and challenges associated with different international forums for developing a long-term international agreement on AMR. To be effective, fair, and feasible, an enduring legal agreement on AMR will require a combination of universal, differentiated, and individualized requirements, nationally determined contributions that are regularly reviewed and ratcheted up in level of ambition, a regular independent scientific stocktake to support evidence informed policymaking, and a concrete global goal to rally support. (shrink)

Dominant normative theories of armed conflict orientate themselves around the ultimate goal of peace. Yet the deployment of these theories in the international sphere appears to have failed in advancing toward this goal. In this paper, we argue that one major reason for this failure is these theories’ use of essentially contested concepts—that is, concepts whose internally complex character results in no principled way of adjudicating between rival interpretations of them. This renders the theories susceptible to manipulation by international actors (...) who are able to pursue bellicose policies under the cover of nominally pacific frameworks, and we show how this happened historically in a case study of the Korean War of 1950–1953. In order to better serve the goals of peace, we suggest, the rules of war should be reframed to simpler, but more restrictive, normative principles. (shrink)

Científicos del sistema Tierra han demostrado que el planeta es un sistema adaptativo-complejo y que algunos procesos naturales ya no operan en condiciones seguras para preservar la vida. Destaca que poco se ha hecho por explorar las implicaciones en la arena jurídica para responder ante los retos que estas condiciones presuponen para la vida humana y para nuestra supervivencia como especie. Aquí se sostiene que, para mantener el buen funcionamiento planetario, se requiere de una articulación efectiva entre el razonamiento jurídico, (...) su argumentación y la ciencia del sistema Tierra. Al hacer una exploración de la literatura jurídica y del sistema Tierra, este artículo tiene como objetivo exponer el primer esfuerzo sobre cómo debería adaptarse el razonamiento jurídico y su argumentación a un enfoque del sistema Tierra, utilizando para ello diferentes casos de estudio, resoluciones y tesis jurisprudenciales. Al hacerlo, se exhibe la necesidad de erradicar concepciones erróneas subyacentes al antropocentrismo jurídico, para ajustar la interpretación y aplicación del derecho a realidades ecológicas científicamente más precisas. (shrink)

We present a decision-theoretically motivated notion of contraction which, we claim, encodes the principles of minimal change and entrenchment. Contraction is seen as an operation whose goal is to minimize loses of informational value. The operation is also compatible with the principle that in contracting A one should preserve the sentences better entrenched than A (when the belief set contains A). Even when the principle of minimal change and the latter motivation for entrenchment figure prominently among the basic intuitions in (...) the works of, among others, Quine and Ullian (1978), Levi (1980, 1991), Harman (1988) and Gärdenfors (1988), formal accounts of belief change (AGM, KM – see Gärdenfors (1988); Katsuno and Mendelzon (1991)) have abandoned both principles (see Rott (2000)). We argue for the principles and we show how to construct a contraction operation, which obeys both. An axiom system is proposed. We also prove that the decision-theoretic notion of contraction can be completely characterized in terms of the given axioms. Proving this type of completeness result is a well-known open problem in the field, whose solution requires employing both decision-theoretical techniques and logical methods recently used in belief change. (shrink)

Mechanistic explanation involves the attribution of functions to both mechanisms and their component parts, and function attribution plays a central role in the individuation of mechanisms. Our aim in this paper is to investigate the impact of a perspectival view of function attribution for the broader mechanist project, and specifically for realism about mechanistic hierarchies. We argue that, contrary to the claims of function perspectivalists such as Craver, one cannot endorse both function perspectivalism and mechanistic hierarchy realism: if functions are (...) perspectival, then so are the levels of a mechanistic hierarchy. We illustrate this argument with an example from recent neuroscience, where the mechanism responsible for the phenomenon of ephaptic coupling cross-cuts the more familiar mechanism for synaptic firing. Finally, we consider what kind of structure there is left to be realist about for the function perspectivalist. (shrink)

Ectogenesis, or “artificial womb technology,” has been heralded by some, such as prominent feminist Shulamith Firestone, as a way to liberate women. In this chapter, we challenge this view by offering an alternative analysis of the technology as relying upon and perpetuating a problematic model of pregnancy which, rather than liberating women, serves to devalue them. We look to metaphysics as the abstract study of reality to elucidate how the entities in a pregnancy are related to one another. We consider (...) two models of the metaphysics of pregnancy: (1) the Parthood Model, whereby the fetus is a part of what/who gestates it; and (2) and the Fetal Container Model, whereby the gestator is a container for the fetus. We suggest that under the assumption of the Fetal Container Model, we are more likely to think that any container will suffice for gestation, even an artificial one. In contrast, under the assumption of the Parthood Model, we are less likely to treat the gestator as interchangeable or replaceable, given the parthood relationship between gestator and fetus. This chapter argues that ectogenesis is conceptually linked to the Fetal Container Model and advocates a more cautious approach in promoting ectogenesis as a tool for women’s liberation. (shrink)

Drawing on early work on ethical leadership, we argue that when leaders engage in leader moral hypocrisy (i.e., ethical promotion without ethical demonstration), followers can experience psychological reactance—a negative response to a perceived restriction of freedom—which can have negative downstream consequences. In a survey of employee–manager dyads (study 1), we demonstrate that leader moral hypocrisy is positively associated with follower psychological reactance, which increases follower deviance. In two subsequent laboratory experiments, we find similar patterns of results (study 2) and explore (...) potential alternative mechanisms (study 3). We demonstrate in a final experiment with working adults that the relationship between leader moral hypocrisy and psychological reactance is partly explained by increased perceptions of a leader’s use of power (study 4). We discuss the implications of our findings and advocate for further understanding of the risks associated with psychological reactance in response to leaders and other workplace situations. (shrink)

In this paper, we draw attention to an unintended but severe side effect of just war thinking: the fact that it can impose barriers to making peace. Investigating historical material concerning a series of conflicts in China during the early twentieth century, we suggest that operating in a just war framework might change actors' identities and interests in a way that makes peacemaking an unavailable action. But since just war theory places significant normative constraints on how long wars can be (...) continued, it might thus be self-defeating, in the sense that those who adopt it may undermine the very goals which it is supposed to serve. Whether this finding calls for a revision of existing ethical frameworks governing warfare will depend on whether there are possible alternatives to just war theory that perform better at reining in unjust violence. (shrink)

Autonomous vehicles (AV) offer promising benefits to society in terms of safety, environmental impact and increased mobility. However, acute challenges persist with any novel technology, inlcuding the perceived risks and trust underlying public acceptance. While research examining the current state of AV public perceptions and future challenges related to both societal and individual barriers to trust and risk perceptions is emerging, it is highly fragmented across disciplines. To address this research gap, by using the Web of Science database, our study (...) undertakes a bibliometric and performance analysis to identify the conceptual and intellectual structures of trust and risk narratives within the AV research field by investigating engineering, social sciences, marketing, and business and infrastructure domains to offer an interdisciplinary approach. Our analysis provides an overview of the key research area across the search categories of ‘trust’ and ‘risk’. Our results show three main clusters with regard to trust and risk, namely, behavioural aspects of AV interaction; uptake and acceptance; and modelling human–automation interaction. The synthesis of the literature allows a better understanding of the public perception of AV and its historical conception and development. It further offers a robust model of public perception in AV, outlining the key themes found in the literature and, in turn, offers critical directions for future research. (shrink)

The paper includes a series of letters exchanged between the author and the late Professor Feyerabend, concerning the best "method" for military intelligence, as a test case for the role of conceptual frameworks in philosophy of science. The letters deal with issues like: Is it possible to make an intelligence estimate without a conceptual framework? Does such a framework have any 'positive' role? If so, how should a conceptual framework in intelligence be built? What risks lurk within it? Is it (...) possible to indicate methods for intelligence estimates which are 'better' and more 'successful' than others? (shrink)

While the evidential problem of evil has been enormously influential within the contemporary philosophical literature—William Rowe’s 1979 formulation in “The Problem of Evil and Some Varieties of Atheism” being the most seminal—no academic research has explored what cognitive mechanisms might underwrite the appearance of pointlessness in target examples of suffering. In this exploratory paper, we show that the perception of pointlessness in the target examples of suffering that underwrite Rowe’s seminal formulation of the problem of evil is contingent on the (...) absence of broader context. In other words, we show that when such suffering is presented alongside broader contextual information, the appearance of pointlessness, on average, significantly diminishes. In §1 we briefly elucidate Rowe’s formulation of the problem of evil and the thought experiment that motivates a key premise. In §2 and §3 respectively, we briefly explain our hypothesis regarding Rowe’s case and our methods for testing these hypotheses. In §4, we elucidate our results, and in §5 we explore some of the philosophical implications of our findings and gesture towards some areas for future research. Finally, in §6, we briefly connect our research to some of the established philosophical literature on suffering and narrative before concluding. (shrink)

Mill defines utilitarianism as the combination of a “theory of life” and a moral claim: only pleasure and freedom from pain are desirable as ends, and the promotion of happiness is the sole goal of moral action. So defined, utilitarianism is open to ad hominem pessimistic objection: a “theory of life” which entails the impossibility of happiness fits poorly with a morality centered on its promotion. The first two challenges Mill confronts in Utilitarianism share this pessimistic structure. Interestingly, however, these (...) challenges paint inverted pictures of the best utilitarian life: one suggests this life is satisfying but ignoble, the other that it is noble but unsatisfying. I explain Mill's treatment of both challenges as genuinely pessimistic interpretations of utilitarianism's “theory of life.” Read through the lens of Mill's engagement with pessimism, these challenges point to distinctive conceptions of dignity and satisfaction that play a significant role in Mill's ethics. (shrink)

The five of us research and teach risk analysis with an eye towards decision support. Our work has been dedicated to taming risks and helping to make challenging decisions. But nothing had prepared us for the Covid-19 pandemic. We first had to grapple with the news coming from abroad, including, for some of us, our home countries. Then, some information and research, but mostly opinions, started coming in from our academic community, and we felt the tensions. Finally, the UK went (...) into an unofficial and then official lockdown, and all University staff were asked to redirect their research capacity so as to support the national effort for risk analysis and decision support. As we write this on the 20th of April, many countries, including the UK, are starting to consider how to get out of lockdown. Like the previous stages of the pandemic, there is little data, perhaps a bit more research, surely many more opinions, and definitely an overwhelming amount of personal experiences and thoughts. Here we reflect on all of the above, just in case it can help the readers of this Minds in Society flash editorial to think and act, or at least, to not have to do so entirely on their own. As it can be expected, our collage introduces more questions than it can answer. (shrink)

Nietzsche suggests that part of what it is to experience something as beautiful is to experience it as beneficial in the highest degree. He defends this claim by suggesting that it alone captures the experience of beauty typical of artists. I argue that this is best understood as pointing to an explanatory argument: Nietzsche takes his view to make sense of an effect beautiful objects have on artists. This effect is, I suggest, gratitude. Beautiful objects inspire feelings of gratitude within (...) artists, moving them to create works of art celebrating those objects as a form of thanksgiving. Insofar as gratitude is typically generated by objects viewed as beneficial, Nietzsche’s view of beauty is well-positioned to explain this effect. (shrink)

This paper examines a commentary of Aristotle's Peri hermeneias, preserved in a single manuscript in the Biblioteca Nacional de España, that is commonly attributed to the fourteenth-century theolog...

Busca identificar as produções acadêmicas dos egressos dos cursos de mestrado e doutorado do Programa de Pós-graduação em Ciência da Informação da Universidade Federal da Paraíba que possuem eixos temáticos relacionados às tecnologias da informação e comunicação, a fim de subsidiar a inquietação que originou a questão norteadora da pesquisa, a saber: Existe interesse dos pesquisadores da CI em discutir criticamente acerca da fundamentação, consistência e qualidade das informações produzidas e compartilhadas perante o alto índice de produção e disseminação ocasionado (...) pelo avanço das TICs e, que trazem em sua essência posicionamentos críticos-reflexivos quanto à produção, uso e compartilhamento das informações diante do progresso dessas tecnologias. A pesquisa traz resultados quantitativos e qualitativos sobre os discentes e docentes do PPGCI/UFPB quanto aos interesses e posicionamentos críticos dos seus pesquisadores. Enfatiza a preocupação com a necessidade de habilitar os usuários das TICs para melhor aproveitar a dinamicidade e a capacidade produtiva e de compartilhamento resultantes dos avanços tecnológicos. (shrink)

In this paper, I reflect on Descartes' employment of the meditational genre in the weaving of the text of the Meditations. In the first part, the possible influences behind Descartes' choice of the meditational genre are examined. The second part of the paper attempts to spell out the significance of Descartes' use of the meditational form. The claim advanced here is that Descartes adopted this unique genre ultimately to further his radical philosophical project of a subject-centred theory of knowledge and (...) a new metaphysical Weltbild, with the self catapulted to the central stage and the physical world reduced to an object of the subject's act of representation. (shrink)

Purpose: The purpose of this article is to examine the unique challenges faced by choir directors in Ghana and provide recommendations for managing and thriving in this context. It aims to highlight the importance of resilience, resourcefulness, and cultural sensitivity in navigating the funding constraints, limited resources, intense competition, and cultural expectations that characterize the Ghanaian choir environment. Methodology: The methodology used in this article is not explicitly stated. However, the recommendations and insights provided are based on a combination of (...) scholarly research, professional experiences, and observations related to choir management in Ghana. The authors gathered data through a literature review, interviews, and observations to understand the challenges faced by choir directors and identify effective strategies for managing them. Findings: The findings of this study suggest that choir directors in Ghana can overcome challenges and contribute to the country's musical heritage by implementing specific strategies. These include seeking diverse funding sources, engaging with local businesses, cultural organizations, and government agencies for financial support, promoting the unique qualities of their choirs, and emphasizing cultural authenticity, repertoire diversity, and innovative performances to attract audiences and sponsors. Recommendations: The theoretical ideas that informed this article's recommendations and the actual experiences that took place in the Ghanaian choir context validated them. The authors likely drew upon their expertise, scholarly research, and consultation with practitioners to develop and validate these recommendations. They should seek diverse funding sources, engage with local businesses and organizations, and promote the unique qualities of their choirs to attract audiences and sponsors. Policymakers are encouraged to support the development and sustainability of choirs in Ghana by recognizing their cultural significance and providing financial and logistical support. Policies that promote the arts, cultural preservation, and community engagement can contribute to the growth and success of choirs. Additionally, policies addressing funding constraints and resource limitations can alleviate some of the challenges faced by choir directors, enabling them to thrive and contribute to Ghana's musical landscape. The article aims to inspire and guide directors in managing choirs in Ghana, highlighting the potential for cultural enrichment and artistic excellence within this unique context. (shrink)

ḳunṭres 1. ʼOr ha-emunah --ḳunṭres 2. Śimḥah ṿe-hitḥazḳut, ha-derekh le-hatsalah li-nevukhim.

Just as it is impossible to understand the American religious landscape without some familiarity with evangelicalism, one cannot grasp the shape of contemporary Christian ethics without knowing the contributions of evangelical Protestants. This newest addition to the Library of Theological Ethics series begins by examining the core dynamic with which all evangelical ethics grapples: belief in an authoritative, inspired, and unchanging biblical text on the one hand, and engagement with a rapidly evolving and increasingly post-Christian culture on the other. It (...) explores the different roles that scholars and popular figures have played in forming evangelicals' understandings of Christian ethics. And it draws together the contributions of both senior and emerging figures in painting a portrait of this diverse, vibrant, and challenging theological and ethical tradition. This book represents the breadth of evangelical ethical voices, demonstrating that evangelical ethics involves nuance and theological insight that far transcend any political agenda. Contributors include David P. Gushee, Carl F. H. Henry, Jennifer McBride, Stephen Charles Mott, William E. Pannell, John Perkins, Soong-Chan Rah, Gabriel Salguero, Francis Schaeffer, Ron Sider, Helene Slessarev-Jamir, Glen H. Stassen, Eldin Villafañe, Allen Verhey, Jim Wallis, Nicholas Wolterstorff, and John Howard Yoder. The Library of Theological Ethics series focuses on what it means to think theologically and ethically. It presents a selection of important, and otherwise unavailable, texts—English-language texts and translations that have fallen out of print, new translations, and collections of significant statements about problems and themes of special importance—in an easily accessible form. This series enables sustained dialogue on new and classic works in the field. (shrink)

ḳaṿim le-havanat ha-hisṭoriah ha-yehudit ṿeha-ʻolamit.