Fanconi anemia (FA) is generally classified as a DNA repair disorder, conferring a genetic predisposition to cancer and prominent bone marrow failure (BMF) in early childhood. Corroborative human and murine studies point to a fetal origin of hematopoietic stem cell (HSC) attrition under replicative stress. Along with intriguing recent insights into non‐canonical roles and domain‐specific functions of FA proteins, these studies have raised the possibility of a DNA repair‐independent BMF etiology. However, deeper mechanistic insight is critical as current curative options (...) of allogeneic stem cell transplantation and emerging gene therapy have limited eligibility, carry significant side effects, and involve complex procedures restricted to resource‐rich environments. To develop rational and broadly accessible therapies for FA patients, the field will need more faithful disease models that overcome the scarcity of patient samples, leverage technological advances, and adopt investigational clinical trial designs tailored for rare diseases. (shrink)

Empirical evidence suggests that perceptual‐motor simulations are often constitutively involved in language comprehension. Call this “the simulation view of language comprehension”. This article applies the simulation view to illuminate the much‐discussed phenomenon of copredication, where a noun permits multiple predications which seem to select different senses of the noun simultaneously. On the proposed account, the (in)felicitousness of a copredicational sentence is closely associated with the perceptual simulations that the language user deploys in comprehending the sentence.

In this article, we study a minimal change approach to preference dynamics. We treat a set of preferences as a special kind of theory, and define minimal change preference contraction and revision operations in the spirit of the Alchourrón, Gärdenfors, and Makinson theory of belief revision. We characterise minimal contraction of preference sets by a set of postulates and prove a representation theorem. We also give a linear time algorithm which implements minimal contraction by a single preference. We then define (...) minimal contraction by a set of preferences, and show that the problem of a minimal contraction by a set of preferences is NP-hard. (shrink)

Edited in collaboration with FoLLI, the Association of Logic, Language and Information this book constitutes the refereed proceedings of the Second Interdisciplinary Workshop on Logic, Language, and Meaning, TLLM 2020, held in Tsinghua, China, in December 2020. The 12 full papers together presented were fully reviewed and selected from 40 submissions. Due to COVID-19 the workshop will be held online. The workshop covers a wide range of topics where monotonicity is discussed in the context of logic, causality, belief revision, quantification, (...) polarity, syntax, comparatives, and various semantic phenomena in particular languages. (shrink)

BackgroundThe high incidence of post-stroke depression during rehabilitation exerts a negative effect on the treatment and functional recovery of patients with stroke and increases the risk of mortality. It is necessary to screen PSD in the rehabilitation stage and thus provide effective intervention strategies. However, existing measurements used to assess PSD in the rehabilitation stage in patients with stroke lack specificity. This study aimed to develop a clinical measure to assess symptoms of PSD in the rehabilitation stage.MethodsThe research team created (...) the initial items through a literature review and semi-structured interviews of patients with stroke. Then, the symptom-related items were estimated by three panels: healthcare professionals, Delphi experts, and patients with stroke in the rehabilitation stage.ResultsThe literature review and semi-structured interview produced 51 symptom-related items including six domains, and the items were reduced to 47 by the healthcare professionals. The symptom-related items were further reduced to 33 items by a two-round Delphi consultation. The initiative coefficients of the two Delphi rounds were 71.4 and 100%, the expert authority coefficients were both 0.85, Kendall’s W were 0.152 and 0.408, and the coefficient of variation were 0.05–0.32 and 0.00–0.18, respectively. The item-level content validity index was 0.53–1.00, the scale-level CVI/universal agreement was 0.26, and the S-CVI/average was 0.85 for the first found Delphi consultation; the I-CVI was 0.67–1.00, the S-CVI/UA was 0.61, and the S-CVI/Ave was 0.97 for the second round Delphi consultation. All content validity indicators have been significantly improved compared with the first round. Using mean ≥ 4 and full score ≥ 0.5, combined with CV ≤ 0.16 as the item criteria, a clinical measure of PSD with 33 items and 6 dimensions was finally formed after two rounds. The patients with stroke made no further revisions after evaluation.ConclusionThe research team developed a specific tool with good content validity to assess the symptoms of PSD in the rehabilitation stage. (shrink)

The small- and medium-sized tourism and hospitality enterprises are the main forms of enterprises in Macao. This study put forward a new framework of survival and sustainable development from the perspective of competitive advantage and regional soft environment, which significantly holds theoretical and practical research value. The study obtained cross-sectional data of 317 small- and medium-sized tourism and hospitality enterprises in Macao through a large-scale questionnaire survey. This article used exploratory factor analysis and confirmatory factor analysis to test the reliability (...) and validity of each factor system and its measurement scale. The variance analysis is used to judge the differences between the elements. The regression analysis is used to verify the hypothesis of a causal relationship between factors. The structural equation analysis is used to fit the model and make necessary amendments. The results reveal that the government service environment has a significant positive impact on the ability of an entrepreneur. In addition, the regional soft environment significantly impacts the competitive advantage of small- and medium-sized tourism and hospitality enterprises in Macao. Contrary, the impact of laws of Macao on the acquisition of financial resources and the promotion of entrepreneur ability and innovation ability is found insignificant. In conclusion, the results showed that market of Macao lacks venture investors where enterprises cannot obtain funds through angel financing or risk financing. (shrink)

We examine whether the level of integrity in a society, i.e., social integrity, affects stock price crash risk. We explore two competing hypotheses. On the one hand, exposure to high levels of integrity may reduce managers’ incentives to obfuscate information, thereby leading to lower crash risk. On the other hand, social integrity may weaken outsiders’ monitoring of managerial behaviors, thus giving managers more opportunities to obfuscate information and, consequently, leading to higher crash risk. Using a sample of Chinese listed firms, (...) we find that firms located in regions with higher integrity have lower future stock price crash risk. This result is confirmed by a difference-in-difference analysis with an exogenous shock to social integrity. Further analysis suggests that increased information transparency is a potential channel through which social integrity affects stock price crash risk. Cross-sectional analyses suggest that the negative effect of social integrity on crash risk is more pronounced in firms with weaker internal control systems and firms with less negative media coverage. Overall, our study provides novel evidence that the ethical environment plays a significant role in shaping business ethics and influencing stock price crash risk. (shrink)

Resumo: Uma das medidas mais significativas do progresso de uma nação, no fornecimento de educação para pessoas com deficiências, bem como uma medida de quão bem seus sistemas de apoio operam e quão longe a sociedade se encontra, em seu desenvolvimento social, é o crescimento do ensino superior para pessoas com deficiências. Os resultados indicaram que os alunos surdos com experiência escolar geral apresentaram melhor adaptabilidade. O modelo de integração era mais adequado para aumentar a conscientização dos alunos surdos sobre (...) a interação social e a adaptabilidade escolar. Ademais, os alunos surdos tinham uma demanda maior por orientação profissional. No entanto, é importante observar que o modelo de treinamento de integração ainda possui espaço para aprimoramentos. Com base nos resultados das referidas pesquisas e nos problemas da prática, o presente artigo apresenta as sugestões e pareceres de contramedidas correspondentes. O artigo sugere que devemos construir um modelo educativo de integração baseado no conceito “trindade”, orientado para talentos socialmente integrados em aplicações artísticas, aperfeiçoar o sistema de gestão da educação de integração, melhorar o sistema de apoio ao aprendizado de estudantes universitários surdos sob a liderança da escola, modificar e reconstruir o sistema curricular de integração das áreas de arte e artesanato e fortalecer o apoio e a orientação da sociedade para a construção de um ambiente de integração. (shrink)

Firstly, the authors analyzed the properties of primary-onditionals and secondary-conditionals, establishthe minimum system $C2L_{m}$ of primary-conditionals and secondary-conditionals, and then prove some of the formal theorems of the system which have important intuitive meanings. Secondly, the authors constructed the neighborhood semantics, prove the soundness of $C2L_{m}$ , introduce a general concept of canonical model by the neighborhood semantics, and then prove the completeness of $C2L_{m}$ by the canonical model. Finally, according to the technical results of the minimum system $C2L_{m}$ , (...) the authors discuss some of the important problems concerning primary-conditionals and secondary- onditionals. (shrink)

Flap EndoNuclease‐1 (FEN‐1) is a multifunctional and structure‐specific nuclease involved in nucleic acid processing pathways. It plays a critical role in maintaining human genome stability through RNA primer removal, long‐patch base excision repair and resolution of dinucleotide and trinucleotide repeat secondary structures. In addition to its flap endonuclease (FEN) and nick exonuclease (EXO) activities, a new gap endonuclease (GEN) activity has been characterized. This activity may be important in apoptotic DNA fragmentation and in resolving stalled DNA replication forks. The multiple (...) functions of FEN‐1 are regulated via several means, including formation of complexes with different protein partners, nuclear localization in response to cell cycle or DNA damage and post‐translational modifications. Its functional deficiency is predicted to cause genetic diseases, including Huntington's disease, myotonic dystrophy and cancers. This review summarizes the knowledge gained through efforts in the past decade to define its structural elements for specific activities and possible pathological consequences of altered functions of this multirole player. BioEssays 27:717–729, 2005. © 2005 Wiley Periodicals, Inc. (shrink)

本书内容包括什么是法社会学、多元化的法概念、社会·法律·法律文化、法与社会制度、法与社会发展、法与社会分层、法与社会问题、法与社会控制、法与社会化、法律职业、法的实现等11章。.

In order to better understand the individual-level motives for ticket-splitting, Taiwan's Election and Democratization Study has since 2001 included a question aimed at measuring respondents’ preferences for checks and balances. We argue that this set of questions, designed to measure a combination of Fiorina's policy-balancing hypothesis and Ladd's cognitive Madisonianism, is inconsistent with principles of survey methodology and thus produces data that are suboptimal. Following a method developed by Carsey and Layman, we propose an alternative concept, the policy-balancing index derived (...) from the perceived ideological distance between respondent and political parties, which both avoids methodological violations and provides us with a more precise concept to work with. We test the index and find it to be a significant determinant of ticket-splitting behavior. (shrink)

To improve the personalized service of cultural tourism, anticipatory calculation has become an essential technology in the content design of intelligence navigation system. Culture tourism, as a form of leisure activity, is being favored by an increasing number of people, which calls for further improvements in the cultural consumption experience. An important component of cultural tourism is for tourists to experience intangible cultural heritage projects with local characteristics. However, from the perspective of user needs and the content adaptive system, there (...) are few suitable intelligent navigation and user demand anticipatory systems for intangible cultural heritage content. Purple clay culture is one of the first batches of national intangible cultural heritage protection projects in China. Therefore, taking purple clay culture exhibition as an example, this paper attempts to analyze the personalized information demand of tourism consumption experience in intangible cultural heritage communication activities with affective computing and meaning-driven innovative design method, by taking the content design in the navigation system as the research object. This paper uses the theory of planned behavior to calculate the relationship between tourists’ attitude, experience behavior, and display information demand. The findings indicate two issues. First, tourists’ demand for the entertainment and leisure attributes of intangible cultural heritage is greater than the demand for educational function attributes. Second, the meaning elements of information can change tourists’ beliefs in intangible cultural heritage and affect their attitude and behavior toward such heritage. According to the research results, strengthening the meaning elements of specific group information can improve people’s cultural identity and tourism satisfaction. The research results provide the basis for the content design direction of future museum intelligent navigation systems. (shrink)

The philosophy of time and change in Chinese Buddhism originated in a short treatise written by an early Chinese monk, Sengzhao (c. 384-414 CE). In this treatise, “On the Immutability of Things (wubuqianlun),” Sengzhao proposed a revolutionary theory of time and change that opposed the traditional Chinese notion of change established by Confucianism and Daoism. His thesis of the immutability of things also seemingly defies a fundamental Buddhist teaching about the impermanence of things. More than a thousand years after Sengzhao, (...) a monk in the Ming dynasty, Kongyin Zhencheng (1546–1617) published the “Logical Investigation of the Thesis of No-Motion of Things (Wubuqian zhengliang lun) to refute Sengzhao's theory of the immutability of things. Because of Sengzhao's esteemed status as one of the early founders of Chinese Buddhism, Zhencheng's critique of Sengzhao caused an uproar among his contemporaries. The ensuing exchange constituted one of the major debates in the history of Chinese Buddhism (Lin 2018; Liu et al., 2020; Fang 1998; Zhu 2012) and was considered a significant event in the “rise of Buddhist scholasticism” (Liu et al., 2020: 7). This entry will carefully analyze Sengzhao's treatise on time and the immutability of things, highlighting the philosophical disagreements between him and Zhencheng. It will also place Sengzhao in his philosophical lineage to examine how he derived insights from Kumarajiva and Nāgārjuna, and how he might have influenced Chan Buddhism's conception of time. This entry will present the uniqueness of Sengzhao's conception of time that marks his departure from the Chinese tradition. (shrink)

To improve the movie box office prediction accuracy, this paper proposes an adaptive attention with consumer sentinel for movie box office prediction. First, the influencing factors of the movie box office are analyzed. Tackling the problem of ignoring consumer groups in existing prediction models, we add consumer features and then quantitatively analyze and normalize the box office influence factors. Second, we establish an LSTM box office prediction model and inject the attention mechanism to construct an adaptive attention with consumer sentinel (...) for movie box office prediction. Finally, 10,398 pieces of movie box office dataset are used in the Kaggle competition to compare the prediction results with the LSTM-AACS model, LSTM-Attention model, and LSTM model. The results show that the relative error of LSTM-AACS prediction is 6.58%, which is lower than other models used in the experiment. (shrink)

Modern logic is an active agent all across the university today, connecting disciplines, and transcending traditional boundaries. This book demonstrates this general role in the special setting of a conference at Tsinghua University, where modern logic was already taught in the 1930s by pioneers like Jin Yeulin. This boon contains an unusual dialogue between Chinese logicians and international colleagues representing a wide range of disciplines, including philosophy, mathematics, linguistics computer science, cognitive science, and the social sciences. The focus of this (...) encounter is not only to advance logic in its university-wide role but also to look for its application in modern society. (shrink)

Drawing on the theory of cognitive-affective processing system and that of construal level, we propose a moderated mediation model illustrating the relationship among abusive supervision, shame, construal level, and work withdrawal. We tested this model with a two-source time-lagged survey of 387 employees from 129 work teams in central and East China. Results revealed that abusive supervision had a positive association with the emotion of shame and supported the mediating role of shame linking abusive supervision to work withdrawal. Besides, our (...) findings supported the buffering effect of construal level on the shame-work withdrawal relationship as well as the indirect relationship between abusive supervision and work withdrawal channeled through the emotion of shame. (shrink)

This paper describes the investigations performed to better understand two-stage rotor speed matching in a contrarotating fan. In addition, this study develops a comprehensive measuring and communication system for a contrarotating fan using ZigBee network. The investigation method is based on three-dimensional RANS simulations; the RANS equations are solved by the numerical method in conjunction with a SST turbulence model. A wireless measurement system using big data method is first designed, and then a comparison is done with experimental measurements to (...) outline the capacity of the numerical method. The results show that when contrarotating fan worked under designed speed, performance of two-stages rotors could not be matched as the designed working condition was deviated. Rotor 1 had huge influences on flow rate characteristics of a contrarotating fan. Rotor 2 was influenced by flow rates significantly. Under large flow rate condition, the power capability of rotor 2 became very weak; under working small flow rate condition, overloading would take place to class II motor. In order to solve the performance mismatch between two stages of CRF under nondesigned working conditions, under small flow rate condition, the priority shall be given to increase of the speed of rotor 1, while the speed of rotor 2 shall be reduced appropriately; under large flow rate condition, the speed of rotor 1 shall be reduced and the speed of rotor 2 shall be increased at the same time. (shrink)

Despite numerous published writings on China's regional role, the world still knows very little about Beijing's perception and strategy. This article seeks to make an intellectual contribution in understanding China's foreign policy and its efforts to participate in East Asian integration. This article argues that under the rhetoric of peaceful development and community building, China's foreign policy is pragmatic and changes with the tide of events in international relations. China's participation in regional integration serves as a good case for examining (...) changes in Beijing's strategy. In the past two decades, China has moved from a reluctant participant of regional affairs to an active participant and potential future leader. China's adjusting role is a consequence of Beijing's pragmatism in policy and its growing economic confidence. Pragmatism has led China to and wait for the proper timing to step onto the world stage. (shrink)

The present study critically evaluates whether school leadership influences student learning homogenously regardless of school contexts. It examined relationships between four principal leadership variables (envisioning, instructional management, promoting professional development, empowerment) and two types of student outcomes (enjoyment in learning science, science achievement,) in different school contexts (in terms of the availability of science resources, quality of science teachers, and school socioeconomic status (SES)). The sample comprised 248,620 students and 9,370 principals in 35 developed countries who participated in the Programme (...) for International Student Assessment (PISA) 2015. Latent profile analysis (LPA) showed that schools operated in three types of school contexts with different levels of science resources, proportion of quality science teachers, and school SES. There were also differences in the pattern of leadership practices across the three types of school contexts. Three-level hierarchical linear modeling (HLM) showed that among the four leadership variables, only instructional management was positively associated with students’ enjoyment of science in schools with less science resources and quality science teachers. Therefore, instructional management had compensatory effects for students in less-endowed schools. In contrast, principal leadership related to envisioning, teacher professional development, and empowerment was not positively related to students’ science learning in all three school contexts. (shrink)

The rapid worldwide spread of COVID-19 forced many countries to enforce complete lockdown and strict quarantine policies. The strict lockdown and quarantine affect the psychological state of people toward cryptocurrency. The current research aims to examine the effect of COVID-19 on Bitcoin prices concerning cumulative deaths and confirmed cases. The research comprises daily data from January 20, 2020, to April 30, 2020, during the initial worldwide breakout of COVID-19. This research employed the augmented Dickey-Fuller test to check the stationarity of (...) data, the co-integration test for the interdependency of variables, and the vector error correction model for identifying the direction and long or short-run relationship between Bitcoin prices and COVID-19. The research results show that Bitcoin prices are negatively significant and related to COVID-19 in the short-run. A unidirectional relationship between Bitcoin prices and cumulative deaths is also observed. Investors and the public’s psychological state were positively significant to Bitcoin prices in the long-term because of cashless transactions, unbanked, and less risky virus traveling. The second reason behind the positive psychological relation is un-centralization and easy-to-make payments by Bitcoin. This study’s finding provides timely evidence to decision-makers on Bitcoin price volatility and its impacts on the public’s psychological states regarding COVID-19. (shrink)