Early embryogenesis of Caenorhabditis elegans provides a striking example of the generation of polarity and the partitioning of cytoplasmic factors according to this polarity. Microfilaments (MFs) appear to play a critical role in these processes. By visualizing the distribution of MFs and by studying the consequences of disrupting MFs for short, defined periods during zygote development, we have generated some new ideas about when and how microfilaments function in the zygote.

While endorsing Gopnik's proposal that studies of the emergence and modification of scientific theories and studies of cognitive development in children are mutually illuminating, we offer a different picture of the beginning points of cognitive development from Gopnik's picture of "theories all the way down." Human infants are endowed with several distinct core systems of knowledge which are theory-like in some, but not all, important ways. The existence of these core systems of knowledge has implications for the joint research program (...) between philosophers and psychologists that Gopnik advocates and we endorse. A few lessons already gained from this program of research are sketched. (shrink)

In this paper, we explore whether the ethical positions of students are firmly entrenched when they enter college, or do they change due to maturity, experience to ethical discussions in coursework, work experience, or a combination of factors. This study compared the ethical attitudes of freshmen and junior accounting majors, and graduate MBA students when confronted with two ethical dilemmas. Undergraduates were found to be more justice oriented than their MBA counterparts, who were more utilitarian in their ethical approach. While (...) males tended to be more utilitarian, they were also more tentative and neutral in their responses. Females expressed more definite ethical positions than males when assessing specific ethical behaviors. Prior exposure to ethics via coursework or employment did not significantly affect ethical attitudes. (shrink)

Background: Hospitals are experiencing an estimated 16.5% turnover rate of registered nurses costing from $44,380 - $63,400 per nurse—an estimated $4.21 to $6.02 million financial loss annually for hospitals in the United States of America. Attrition of all nurses is costly. Most past research has focused on the new graduate nurse with little focus on the mid-career nurse. Attrition of mid-career nurses is a loss for the profession now and into the future. Research objective: The purpose of the study was (...) to explore relationships of professional values orientation, career development, job satisfaction, and intent to stay in recently hired mid-career and early-career nurses in a large hospital system. Research design: A descriptive correlational study of personal and professional factors on job satisfaction and retention was conducted. Participants and research context: A convenience sample of nurses from a mid-sized hospital in a metropolitan area in the Southwestern United States was recruited via in-house email. Sixty-seven nurses met the eligibility criteria and completed survey documents. Ethical considerations: Institutional Review Board approval was obtained from both the university and hospital system. Findings: Findings indicated a strong correlation between professional values and career development and that both job satisfaction and career development correlated positively with retention. Discussion: Newly hired mid-career nurses scored higher on job satisfaction and planned to remain in their jobs. This is important because their expertise and leadership are necessary to sustain the profession into the future. Conclusion: Nurse managers should be aware that when nurses perceive value conflicts, retention might be adversely affected. The practice environment stimulates nurses to consider whether to remain on the job or look for other opportunities. (shrink)

Quine's naturalized epistemology is ambivalent between a modest naturalism according to which epistemology is an a posteriori discipline, an integral part of the web of empirical belief, and a scientistic naturalism according to which epistemology is to be conducted wholly within the natural sciences. This ambivalence is encouraged by Quine's ambiguous use of science, to mean sometimes, broadly, our presumed empirical knowledge and sometimes, narrowly, the natural sciences. Quine's modest naturalism is reformist, tackling the traditional epistemological problems in a novel (...) way; his scientistic naturalism is revolutionary, requiring restriction and reconceptualization of epistemological problems. In particular, his scientistic naturalism trivializes the question of the epistemic standing of the natural sciences, whereas modest naturalism takes it seriously, and can offer a plausible answer. (shrink)

From my Consciousness in Action, ch. 2; see Consciousness in Action for bibligraphy. This chapter revises material from "Kant on Spontaneity and the Myth of the Giving", Proceedings of the Aristotelian Society, 1993-94, pp. 137-164, and "Myth Upon Myth", Proceedings of the Aristotelian Society, 1996, vol. 96, pp. 253-260.

A critical review of four recent works that reflect current conflicts and tensions among feminists regarding new reproductive technologies: In Search of Parenthood by Judith Lasker and Susan Borg; Ethics and Human Reproduction by Christine Overall; Made to Order, Patricia Spallone and Deborah Steinberg, eds. and Reproductive Technologies: Gender, Motherhood and Medicine, Michelle Stanworth, ed. Their positions are evaluated against the background of growing feminist dialogue about the future of reproduction and the bearing of reproductive innovations on such related (...) issues as racism, sexuality, motherhood and abortion. (shrink)

Part of an early version of this paper was read at the University of Warwick in October 1977, and a later version was read at the Newcastle Royal Institute of Philosophy in November 1977 and at Aberystwyth and Oxford in early 1978. Thanks are due to the many colleagues and friends who made helpful comments on early drafts; special thanks to Hugh Mellor, Rita Nolan and Paul Weiss for detailed written criticisms, and to Don Locke, for very helpful discussions.

The current explosion of genetic knowledge and the rapid proliferation of genetic tests has rightly provoked concern that we are approaching a future in which people will be labeled and disadvantaged based on genetic information. Indeed, some have already suffered harm, including denial of health insurance. This concern has prompted an outpouring of analysis. Yet almost all of it approaches the problem of genetic disadvantage under the rubric of “genetic discrimination.”This rubric is woefully inadequate to the task at hand. It (...) ignores years of commentary on race and gender demonstrating the limits of antidiscrimination analysis as an analytic framework and corrective tool. Too much discussion of genetic disadvantage proceeds as if scholars of race and gender had not spent decades critiquing and developing antidiscrimination theory.Indeed, there are multiple links among race, gender, and genetics. Dorothy Roberts has discussed the historical links between racism and genetics, while she and others have begun to map connections between gender and genetics. (shrink)

COVID-19 poses an exceptional threat to global public health and well-being. Recognition of the need to develop effective vaccines at unprecedented speed has led to calls to accelerate research pathways ethically, including by conducting challenge studies ) with SARS-CoV-2. Such research is controversial, with concerns being raised about the social, legal, ethical and clinical implications of infecting healthy volunteers with SARS-CoV-2 for research purposes. Systematic risk evaluations are critical to inform assessments of the ethics of any proposed SARS-CoV-2 CHIs. Such (...) evaluations will necessarily take place within a rapidly changing and at times contested epidemiological landscape, in which differing criteria for the ethical acceptability of research risks have been proposed. This paper critically reviews two such criteria and evaluates whether the use of effective treatment should be a necessary condition for the ethical acceptability of SARS-CoV-2 CHIs, and whether the choice of study sites should be influenced by COVID-19 incidence levels. The paper concludes that ethical evaluations of proposed SARS-CoV-2 CHIs should be informed by rigorous, consultative and holistic approaches to systematic risk assessment. (shrink)

Wollstonecraft's early works express a coherent view of moral psychology, moral education and moral philosophy which guides the construction of her early fiction and educational works. It includes a valuable account of the relation between reason and feeling in moral development. Failure to recognize the complexity and coherence of the view and unhistorical readings have led to mistaken criticisms of Wollstonecraft's position. Part I answers these criticisms; Part II describes and textually supports her view.

This paper proceeds from a sense of dissatisfaction with much of current moral argument about defence policy, in particular the role of nuclear weapons. Discussions of the moral issues tend to divide into two distinct kinds of writing: on the one hand, impassioned calls to action based on and allied with equally impassioned moral exhortations; and on the other hand, usually in academic contexts, meticulous analyses and comparisons of aspects of nuclear policy with paradigm cases of acknowledged moral categories or (...) requirements, with the object of showing by analogy with these that the particular aspect of policy under discussion is or is not morally wrong. My unease is caused by the fact that, while it is difficult not to respond to the impassioned style of argument, as one recognizes in it a practical and moral urgency which our situation seems to demand, nevertheless it plainly appeals only to those already convinced of its conclusions. The unconverted tend to regard it with suspicion or disdain, for in contrast to the analytical style, which manifestly seeks to compel the intellect, the impassioned style seems to make its effect by stirring the emotions as much as if not instead of by compelling the intellect. On the other hand the analytical style can seem curiously irrelevant, even trivial, in relation to the issue. For instance, it has been argued that since: nuclear war is a moral disaster; deterrence is threatening or intending to wage nuclear war; it is wrong to threaten or intend to do something wrong; therefore: deterrence is wrong, and should be abandoned. It is hard to believe that defenders of deterrence as the cornerstone of defence policy are going to be persuaded by such an argument to abandon their advocation of it, if only because the argument totally ignores the object of deterrence. (shrink)

In his paper [6], Greg Restall conjectured that a logic supports a naïve comprehension scheme if and only if it is robustly contraction free, that is, if and only if no contracting connective is definable in terms of the primitive connectives of the logic. In this paper, we present infinitely many counterexamples to Restall''s conjecture, in the form of purely implicational logics which are robustly contraction free, but which trivialize naïve comprehension.

Human genomics is a translational field spanning research, clinical care, public health, and direct-to-consumer testing. However, law differs across these domains on issues including liability, consent, promoting quality of analysis and interpretation, and safeguarding privacy. Genomic activities crossing domains can thus encounter confusion and conflicts among these approaches. This paper suggests how to resolve these conflicts while protecting the rights and interests of individuals sequenced. Translational genomics requires this more translational approach to law.

This note discusses some of the images and ideas that led to the depiction of Eros with the attributes of Herakles, an iconographical type that was developed and elaborated in the Hellenistic and Roman periods.Eros was not, in fact, the first to appropriate for himself the attributes of Herakles. From an early period popular imagination realised that even the mighty Herakles would occasionally be placed in a situation that lesser creatures could take advantage of. Before the Hellenistic period Kerkopes, satyrs (...) and goat-legged Pans made use of whatever opportunities there were to steal Herakles' attributes; thereafter these subhuman thieves appear to have been replaced by a group of Erotes or a single Eros. (shrink)

The more than fifty years of dialogue since Vatican II launched the Catholic Church into the ecumenical movement have resulted in significant convergence, but reception of these results remains slow and inconclusive despite the stunning success of the Joint Declaration on Justification signed in 1999. This presentation explores some of the challenges for reception within the ecclesial and social context of ecumenical relationships today and discusses why the ecumenical imperative is even more critical at this point in time. It also (...) suggests a model of ecclesiology for the reception of relationships of full communion. (shrink)

In this paper I discuss the relationship between model, theories, and laws in the practice of experimental scale modeling. The methodology of experimental scale modeling, also known as physical similarity, differs markedly from that of other kinds of models in ways that are important to issues in philosophy of science. Scale models are not discussed in much depth in mainstream philosophy of science. In this paper, I examine how scale models are used in making inferences. The main question I address (...) in this talk is ``How are fundamental laws involved in the construction of, and inferences drawn from, experimental scale models?'' We shall see that there is a refreshing alternative to the mainstream view that models can serve only as intermediaries between theory and experiment. Using the methodology of scale models, one can use observations on one piece of the world to make inferences about another piece of the world, without involving an intermediate abstract model about which one reasons. The philosophical significance of that point to philosophy of science is that the method of physical similarity, which provides the basis for inferences based upon scale models, is a qualitatively different way in which fundamental laws can be used in analogical reasoning that is truly informative. Finally, as this method provides a formal basis for case-based reasoning, it may be helpful in formalizing methods used in some of the so-called ``special sciences''. (shrink)

To reassure those concerned about wholesale discontinuity between human existence and posthumanity, transhumanists assert shared ground with antiquity on vital challenges and aspirations. Because their claims reflect key misconceptions, there is no shared vision for transhumanists to invoke. Having exposed their misuses of Prometheus, Plato, and Aristotle, I show that not only do transhumanists and antiquity crucially diverge on our relation to ideals, contrast-dependent aspiration, and worthy endeavors but that illumining this divide exposes central weaknesses in transhumanist argumentation. What is (...) more, antiquity’s handling of these topics suggests a way through the impasse in current enhancement debates about human “nature” and helps to resolve a tension within transhumanists’ accounts of what our best moments signify about the ontological requirements for real flourishing. (shrink)

For ages, medicine has had poor access to the fetus inside the mother's womb. But in relatively recent years, the human body has become transparent. The latest breakthroughs of technology have made it possible, from the very beginning of pregnancy, to consider the fetus as an individual who can be examined and sampled. His or her physician may now establish a diagnosis and prognosis and prescribe a treatment in the same way as in traditional medicine.

The contradictions and ambiguities in, admiration for, and potential benefits derived from cheating in modern athletics have numerous parallels in ancient Greek culture. Because both ancient and mo...

This study examined self-recognition processing in both the auditory and visual modalities by determining how comparable hearing a recording of one’s own voice was to seeing photograph of one’s own face. We also investigated whether the simultaneous presentation of auditory and visual self-stimuli would either facilitate or inhibit self-identification. Ninety-one participants completed reaction-time tasks of self-recognition when presented with their own faces, own voices, and combinations of the two. Reaction time and errors made when responding with both the right and (...) left hand were recorded to determine if there were lateralization effects on these tasks. Our findings showed that visual self-recognition for facial photographs appears to be superior to auditory self-recognition for voice recordings. Furthermore, a combined presentation of one’s own face and voice appeared to inhibit rather than facilitate self-recognition and there was a left-hand advantage for reaction time on the combined-presentation tasks. (shrink)

Over the last twenty‐five years, feminist theory has been at the forefront of cultural, disciplinary, and philosophical critique. Yet feminists continue to be represented as engaged in specialized projects of concern only to women or, at best, those interested in “gender issues.” I argue that this is not merely a bit of residual sexism, but a powerful conceptual map which keeps feminist scholarship, no matter how broad its concerns, located in the region of what Simone de Beauvoir called “the Other.” (...) I expose, critique, and explore the consequences of this construction in several contemporary intellectual arenas. (shrink)

Cavendish is critical of two of the experimental sciences of her day: chemistry and microscopy. Rather than creating new things, as their practitioners claim, they produce 'hermaphroditical mixtures'. I trace this startling metaphor to the alchemical tradition and suggest how its origins can help us to understand Cavendish's position. In her view, the chemists and microscopists exaggerate their own power and creativity, and fail to recognise that human creativity belongs primarily to imagination. I show how this theme is worked out (...) in Cavendish's paired texts, Observations on Experimental Philosophy and the fictional Blazing World. (shrink)

After the 2016 election of Donald Trump, many commentators latched on to the accusations Rorty levels at the American Left in Achieving Our Country. Rorty foresaw, they claimed, that the Left's preoccupation with cultural politics and neglect of class politics would lead to the election of a "strongman" who would take advantage of and exploit a rise in populist sentiment. -/- In this paper, I generally agree with these readings of Rorty; he does think that the American Left has made (...) the mistake of putting class on the political backburner. However, I suggest that this position follows from his view that economic security is vital for solidarity. Because economic security is under increasing threat in contemporary America, so too is solidarity. If greater solidarity is a goal of liberal democracy, then class politics, aimed at ending selfishness, ought to be as much a priority for the American Left as is cultural politics, aimed at ending sadism. (shrink)

There are kinds of dialogue that support social justice and others that do the reverse. The kinds of dialogue that support social justice require that anger be bracketed and that hiding in safe spaces be eschewed. All illegitimate ad hominem/ad feminem attacks are ruled out from the get-go. No dialogical contribution can be down-graded on account of the communicator’s gender, race, or religion. As well, this communicative approach unapologetically privileges reason in full view of theories and strategies that might seek (...) to undermine reasoning as just another illegitimate form of power. On the more positive side, it is argued in this paper that social justice dialogue will be enhanced by a kind of “communicative upgrading,” which amplifies “person perception,” foregrounds the impersonal forces within our common social spaces rather than the “baddies” within, and orients the dialogical trajectory toward the future rather than the past. Finally, it is argued in this paper that educators have a pressing responsibility to guide their students through social justice dialogue so that their speech contributes to the amelioration of injustice, rather than rendering the terrain more treacherous. (shrink)

Women themselves, for the most part, think of themselves as the sensible sex, whose business it is to undo the harm that comes of men's impetuous follies. For my part, I distrust all generalizations about women, favourable and unfavourable, masculine and feminine, ancient and modern; all alike, I should say, result from paucity of experience.

Dandruff is a common scalp condition, which frequently causes psychological distress in those affected. Dandruff is considered to be caused by an interplay of several factors. However, the pathogenesis of dandruff remains under‐investigated, especially with respect to the contribution of the hair follicle. As the hair follicle exhibits unique immune‐modulatory properties, including the creation of an immunoinhibitory, immune‐privileged milieu, we propose a novel hypothesis taking into account the role of the hair follicle. We hypothesize that the changes and imbalance of (...) yeast and bacterial species, along with increasing proinflammatory sebum by‐products, leads to the activation of immune response and inflammation. Hair follicle keratinocytes may then detect these changes in scalp microbiota resulting in the recruitment of leukocytes to the inflammation site. These changes in the scalp skin immune‐microenvironment may impact hair follicle immune privilege status, which opens new avenues into exploring the role of the hair follicle in dandruff pathogenesis. Also see the video abstract here: https://youtu.be/mEZEznCYtNs. (shrink)

Visual stimuli that are made invisible by a following mask can nonetheless affect motor responses. To localize the origin of these target priming effects we used the psychological refractory period paradigm. Participants classified tones as high or low, and responded to the position of a visual target that was preceded by a prime. The stimulus onset asynchrony between both tasks varied. In Experiment 1 the tone task was followed by the position task and SOA dependent target priming effects were observed. (...) When the visual position task preceded the tone task in Experiment 2, with short SOA the priming effect propagated entirely to the tone task yielding faster responses to tones on visually congruent trials and delayed responses to tones on visually incongruent trials. Together, results suggest that target priming effects arise from processing before and at the level of the central bottleneck such as sensory analysis and response selection. (shrink)