A widely accepted framework governs biomedical research and the practice of medicine in the civilian sector, but no such framework exists to guide the military in how it should treat its own personnel. Civilian bioethical principles are unsuitable because of fundamental differences between civilian and military core values. This paper proposes a framework for military bioethics. It begins by describing core military values, articulating how they differ from civilian goals and values, and explaining how these differences limit the ability of (...) civilian bioethical principles to govern military biomedicine. The paper then puts forward a set of more appropriate principles for the military and discusses how these principles apply in three main areas of controversy within military bioethics: the use of military personnel as research subjects; the deployment use of biomedical agents; and the obligations of military physicians toward their own troops. (shrink)

In this article, we examine how regulators, prosecutors, and courts might support and encourage the efforts of organizations to not only reintegrate after misconduct but also to improve their conduct in a way that reduces their likelihood of re-offense. We explore a novel experiment in creative sentencing in Alberta Canada that aimed to try to change the behaviour of an industry by publicly airing the root causes of a failure of one the industry’s leaders. Drawing on this case and prior (...) work, we articulate a model for a responsive and restorative approach to organizational misconduct that balances the punitive role of regulators and courts with new roles in supporting and overseeing rehabilitation. (shrink)

Interest in the use of medical data for health research is increasing. Yet, as Elizabeth Ford and colleagues rightly note, there are open questions about the suitability of existing ethical and regulatory oversight frameworks for these research approaches. In their feature article, ‘Should free text data in electronic medical records be shared for research? A citizen’s jury study in the United Kingdom’, Ford et al report the results of a deliberative engagement study in which 18 members of the public were (...) asked whether and under what conditions free text data from medical records should be shared for research purposes. The authors’ explicit aim was to inform national policy on sharing medical text. Public attitudes—stated otherwise, the attitudes of patients whose medical information will ultimately be used under any data sharing policy—are a necessary input into ethical and regulatory decision-making about use of medical data for health research. Though public attitudes will rarely be determinative, they must be weighed in order to uphold the ethical principle of respect for persons.1 Ford et al ’s article is, therefore, an important contribution to …. (shrink)

Addiction is increasingly described as a “chronic and relapsing brain disease”. The potential impact of the brain disease model on the treatment of addiction or addicted individuals’ treatment behaviour remains uncertain. We conducted a qualitative study to examine: (i) the extent to which leading Australian addiction neuroscientists and clinicians accept the brain disease view of addiction; and (ii) their views on the likely impacts of this view on addicted individuals’ beliefs and behaviour. Thirty-one Australian addiction neuroscientists and clinicians (10 females (...) and 21 males; 16 with clinical experience and 15 with no clinical experience) took part in 1 h semi-structured interviews. Most addiction neuroscientists and clinicians did not uncritically support the use of brain disease model of addiction. Most were cautious about the potential for adverse impacts on individuals’ recovery and motivation to enter treatment. While some recognised the possibility that the brain disease model of addiction may provide a rationale for addicted persons to seek treatment and motivate behaviour change, Australian addiction neuroscientist and clinicians do not assume that messages about “diseased brains” will always lead to increased treatment-seeking and reduced drug use. Research is needed on how neuroscience research could be used in ways that optimise positive outcomes for addicted persons. (shrink)

One cue that may facilitate children's word learning is iconicity, or the correspondence between a word's form and meaning. Some have even proposed that iconicity in the early lexicon may serve to help children learn how to learn words, supporting the acquisition of even noniconic, or arbitrary, word–referent associations. However, this proposal remains untested. Here, we investigate the iconicity of caregivers’ speech to young children during a naturalistic free‐play session with novel stimuli and ask whether the iconicity of caregivers’ speech (...) facilitates children's learning of the noniconic novel names of those stimuli. Thirty‐four 1.5‐2‐year‐olds (19 girls; half monolingual English learners and half bilingual English‐Spanish learners) participated in a naturalistic free‐play task with their caregivers followed by a test of word‐referent retention. We found that caregivers’ use of iconicity, particularly in utterances in which they named the novel stimuli, was associated with the likelihood that children learned that novel name. This result held even when controlling for other factors associated with word learning, such as the concreteness and frequency of words in caregiver speech. Together, the results demonstrate that iconicity not only can serve to help children identify the referent of novel words (as in previous research) but can also support their ability to retain even noniconic word‐referent mappings. (shrink)

The rationality of means-end reasoning is the bedrock of the Humean account of practical reasons. But the normativity of such reasoning can not be taken for granted. I consider and reject the idea that the normativity of instrumental reasoning can be explained – either in terms of its being constitutive of the very notion of having an end, or solely in terms of instrumental considerations. I argue that the instrumental principle is itself a brute norm, and that this is consistent (...) with a Humean account of practical reasons. (shrink)

Trust is a critical component of research: trust in the work of co-workers and colleagues within the scientific community; trust in the work of research scientists by the non-research community. A wide range of factors, including internally and externally generated pressures and practical and personal limitations, affect the research process. The extent to which these factors are understood and appreciated influence the development of trust in scientific research findings.

On June 12, 2016, the world witnessed one of the deadliest single shooter massacres in U.S. history. Fifty persons were killed and fifty-three were critically injured. Of those fifty, twenty-three were Puerto Rican; 90% of those killed were Latinx. Their faces spanned the racial kaleidoscope of the African, Latinx, and Indigenous diaspora. Most of them were working class and extremely young (Ochoa 2016). However, these particularities went largely omitted from the coverage of the event that swept the nation under the (...) label of an LGBTQ hate crime. The ubiquity of death of color in the U.S. cannot be overstated. Indeed, many pulses have been lost outside of Pulse nightclub. To many, June 12 may seem like a day among many, lost to the memorials of death no one really wants to remember. In this paper I explore June 12 as we turn the page on its sixth year of remembrance. I make the case for a reading of June 12 as more than an LGBTQ hate crime, but rather as emblematic of a battleground of a sacred space (Latin night at the gay bar) for queer bodies of color. The project establishes a more complex framework for understanding what took place on June 12 that can appreciate the ethno-racial, spiritual, and queer dimensions that foregrounded the event. I maintain that the method of analysis necessitates a different model of theorizing, one that can crystalize the sexuality of terrorism, the whiteness of homonationalism, and thereby the importance of creating sacred space for Latinx queer subjects, many of whom, in the context of June 12, form part of the Puerto Rican diaspora. (shrink)

Jecker makes three major points in her article, “A Broader View of Justice” (2008). First, she argues that justice in healthcare relates to justice in the broader social conditions of society as th...

Daniel Kahneman and his colleagues have made an interesting discovery about people's preferences. In several experiments, subjects underwent two separate ordeals of pain, identical except that one ended with an added amount of diminishing pain. When asked to evaluate these episodes after experiencing both, subjects generally preferred the longer episode--even though it had a greater objective quantity of pain. These data raise an ethical question about whether to respect such preferences when acting on another's behalf. John Broome thinks that it (...) is wrong to add extra pain in order to satisfy a person's preference for a better ending. His explanation for this intuition is that pain is intrinsically bad. I argue against this explanation, and raise several doubts about the moral intuition Broome endorses. In doing so, I offer alternate interpretations of Kahneman's data, and show that these each yield different values which are relevant to the ethical question. (shrink)

We very much appreciate the helpful and generous commentaries in response to “Do Clinicians have a Duty to Participate in Pragmatic Clinical Trials?” (Garland, Morain, and Sugarman 2023). In that a...

In this chapter we look at selfhood in contemporary Confucianism and feminism. We will argue that contemporary Confucians and feminists (and, with some caveats, Confucius and Mencius) have three important points in common when considering the self. In our argument, we will reflect on the debate about Chengyang Li's suggestion that there are important similarities between 仁 (ren ), a term that means roughly "humanity;' "human kindness,'' or "humanity at its best;' and the care ethics advocated by feminists Carol Gilligan, (...) Nel Noddings, and others. Our goal here is not to settle the debates between and among differing Confucians and feminists. Instead, we want to argue that the differences among the views of particular contemporary Confucians and feminists in understanding selfhood and relationality may in fact be smaller than the differences between the two looked at categorically. (shrink)

When making decisions on behalf of someone, is asking what they would have wanted a good way to respect their autonomy? Against prevalent assumptions, I argue that in decisions about the care and treatment of those with advanced dementia, the notion of ‘what one would have wanted’ is conceptually, epistemically, and practically problematic. The problem stems from the disparity between the first-person subjectivity of the past person and that of the present person. The transformative nature of dementia renders the very (...) meaning of ‘what the patient would have wanted’ problematic. When applied to those with advanced dementia, the subjunctive notion is either (i) incoherent, (ii) fundamentally indeterminate, or (iii) normatively irrelevant. (shrink)

The theory of consequences was one of the most important developments in logic during the Middle Ages. The distinction between formal consequences and material consequences was probably introduced by Ockham and soon became the main division of consequences, to be found in nearly all 14th-century treatises on the theory of consequences. This paper discusses the concept of a formal and material consequence according to the English tradition. It is based mainly on Richard Bil­lingham’s De consequentiis, but also takes into account (...) other 14th-century authors. Billingham defines the formal consequence as one where the consequent is understood in the antecedent and differentiates this kind of consequence from the material one. The definition is followed by a list of rules for valid consequences. However, with respect to some of these valid consequences the question arises whether they are formal or not and, if they are formal, how it is possible to explain the criterion of the intelligitur in. After explaining the material and the formal consequence and discussing these difficulties, the question is raised whether the intelligitur in is an appropriate structural criterion to distinguish between formal and material consequences. Finally, two interpretations for the intelligitur in compatible with the text situation are proposed. (shrink)

Simone de Beauvoir's The Second Sex has been heralded as a canonical text of feminist theory. The book focuses on providing an account of the lived experience of woman that generates a condition of otherness. However, I contend that it falls short of being able to account for the multidimensionality of identity insofar as Beauvoir's argument rests upon the comparison between racial and gendered oppression that is understood through the black–white binary. The result of this framework is the imperceptibility of (...) identities at the crossroads between categories of race and gender. Hence, the goal of this article is to explore the margins of Beauvoir's work in order to decenter the “other” of The Second Sex and make known what is made imperceptible by its architecture, using Latina identity as an interventional guide. I conclude that given the prominence of The Second Sex in feminist theory, this shortcoming must be addressed if feminist theorists are to use it responsibly. (shrink)

Que serait la philosophie de Platon sans Socrate ou l'écriture des dialogues? Que resterait-il du travail de Montaigne sans le 'maistre des maistres' socratique ou la 'manière' des Essais? Enfin, l'œuvre de Rancière aurait-elle la même teneur sans Joseph Jacotot, figure incontournable de 'maître ignorant'? La pensée de ces trois auteurs n'existe pas indépendamment de ces figures et de ces écritures si particulières. On ne saurait résumer leurs philosophies, par ailleurs très singulières et différentes, à quelques questions, thèses ou concepts, (...) en les amputant de la mise en scène de ces figures de maîtres si frappantes ou de l'invention stylistique qui leur donne corps et redouble, par les choix d'écriture, leurs gestes philosophiques. Ceci reviendrait à les trahir et à s'interdire l'expérience d'un autre rapport au savoir qu'elles nous invitent à vivre, chacune à sa façon. Cet ouvrage étudie comment ces trois philosophes pensent, à travers ces incarnations, leur relation aux savoirs de leur temps et dans quelle mesure les figures et les écritures de maîtres ignorants qu'ils composent et mobilisent dans leurs textes leur permettent de faire expérimenter au lecteur les gestes philosophiques significatifs de ce rapport au savoir."--Page 4 of cover. (shrink)

Alternative splicing is a critical post‐transcriptional event leading to an increase in the transcriptome diversity. Recent bioinformatics studies revealed a high frequency of alternative splicing. Although the extent of AS conservation among mammals is still being discussed, it has been argued that major forms of alternatively spliced transcripts are much better conserved than minor forms.1 It suggests that alternative splicing plays a major role in genome evolution allowing new exons to evolve with less constraint. BioEssays 25:1031–1034, 2003. © 2003 Wiley (...) Periodicals, Inc. (shrink)

Plus d’une trentaine d’années après la création des premières structures dédiées à sa promotion, l’intégrité scientifique s’est progressivement constituée en tant que thématique de recherche à part entière. Aujourd’hui, une communauté scientifique et académique est réunie autour de cet objet, comme en témoignent la publication d’un nombre croissant d’articles, la création de revues spécialisées ou encore l’organisation de conférences spécifiquement dédiées. Néanmoins, rares sont les travaux qui ont cherché à proposer une vue d’ensemble de la littérature académique relative à l’intégrité (...) scientifique. C’est dans cette perspective que cet état de l’art s’inscrit et entend apporter une contribution. Avec la volonté de rendre compte des principales tendances de la recherche en la matière, nous avons principalement ciblé dans ce travail des articles, des commentaires ou encore quelques documents institutionnels qui ont cherché à approfondir la compréhension que l’on a de l’intégrité scientifique, à explorer les diverses façons de la promouvoir, à mieux cerner l’occurrence des manquements qui y sont liés, ou encore à proposer une lecture de ces questions sous un angle spécifique. Certaines des thématiques qui sont abordées dans cet état de l’art sont incontournables dans le paysage de la recherche et font l’objet d’une attention marquée depuis longtemps, à l’image de l’étude des manquements à l’intégrité scientifique. D’autres, à l’instar des études historiques de l’intégrité scientifique, représentent des pistes de recherche un peu moins explorées mais dont l’intérêt nous semble assez important pour appeler à davantage de développements. (shrink)

Organized by Richard Kearney and Joseph S. O’Leary, the 1979 Colloquium Heidegger et la question de Dieu was of critical importance for the development of phenomenology of religion in France. This special issue introduces the event and its ensuing publication to the English-speaking world. The editors’ historical and thematic contextualizing essay is followed by contributions from six leading philosophers. Richard Kearney sets the stage by updating his original foreword, while Jean-Yves Lacoste presents the central moments in the history of Heidegger’s (...) complicated relationship to Christian thinking. Paul Ricoeur’s “Introductory Note” delivers a well-known challenge to Heidegger in a piece whose brevity belies its impact. Finally, three participants of the 1979 Colloquium, Joseph S. O’Leary, Jean Greisch, and Jean-Luc Marion, reflect back on the significance of this event and its role in developing their own groundbreaking work. The special issue closes with a brief reflection on where we find ourselves in philosophy today. (shrink)

Competitive athletes act within cultures of risk in sports and often decide to return to sport despite having acute health problems. The outcomes of such risky return-to-play decisions can not only negatively affect their future health, but also limit their sports performance or even upset their career paths. Following risk-management-decision theory with its focus on active risk defusing, we developed a model for understanding the process of return-to-play decision making from an athlete’s perspective. Based on the method of active information (...) search, a quasi-naturalistic return-to-play decision scenario was created in order to assess amateur team sport athletes’ decision making strategies. The main goals were to identify different information acquisition patterns and to analyze the influence of social pressure to play hurt on decision making. A total of 72 competitive team sport athletes (36 females, 36 males, m= 25.7 years of age, 3rd to 6th league level) out of three disciplines (volleyball, basketball, and handball) participated in the experimental study. Facing the same medical scenario (a partial tear of the supraspinatus tendon), athletes show different approaches to return-to-play decision making. The main focus is on potential sporting consequences of withdrawal from competition due to injury, while only few players favoring well-informed decisions based on thorough risk analysis. The athletes who chose the medically risky alternative to play hurt mostly employed strategies of active risk defusing, which got activated when severe sporting consequences were perceived. Those who chose to withdraw from competition primarily referred to maximin heuristic, particularly when social pressure to play was reduced. The findings can be used to improve rehabilitation. (shrink)

Are there plausible synchronic constraints on how a subject thinks of herself extended over time? At first glance, Bas van Fraassen’s principle of Reflection seems to prescribe the sort of epistemic authority one’s future self should be taken by one to have over one’s current epistemic states. (The gist of this principle is that I should now believe what I’m convinced I will believe tomorrow.) There has been a general consensus that, as a principle concerning epistemic authority, Reflection does not (...) apply to epistemically non-ideal agents. I agree with this, but argue here that it misses the point of Reflection. Rather than an epistemic principle concerning reasons for belief, Reflection concerns the semantics of belief avowal. I present a non-factual interpretation of Reflection, argue that the principle provides a constraint on the ways in which one can reflectively endorse one’s future epistemic self, and say something about the logic governing such an interpretation. (shrink)

Philosophical accounts of altruism that purport to explain helping behavior are vulnerable to empirical falsification. John Campbell argues that the Good Samaritan study adds to a growing body of evidence that helping behavior is not best explained by appeal to altruism, thus jeopardizing those accounts. I propose that philosophical accounts of altruism can be empirically challenged only if it is shown that altruistic motivations are undermined by normative conflict in the agent, and that the relevant studies do not provide this (...) sort of evidence. Non-normative, purely causal, psychological factors would be empirically relevant only if the notion of altruism is broadened to include the requirement that one recognize certain situations as calling for altruism. But even in that case, the relevant studies are not designed in such a way that could threaten philosophical theories of altruism. (shrink)

On June 12, 2016, the world witnessed one of the deadliest single shooter massacres in U.S. history. Fifty persons were killed and fifty-three were critically injured. Of those fifty, twenty-three were Puerto Rican; 90% of those killed were Latinx. Their faces spanned the racial kaleidoscope of the African, Latinx, and Indigenous diaspora. Most of them were working class and extremely young (Ochoa 2016). However, these particularities went largely omitted from the coverage of the event that swept the nation under the (...) label of an LGBTQ hate crime. The ubiquity of death of color in the U.S. cannot be overstated. Indeed, many pulses have been lost outside of Pulse nightclub. To many, June 12 may seem like a day among many, lost to the memorials of death no one really wants to remember. In this paper I explore June 12 as we turn the page on its sixth year of remembrance. I make the case for a reading of June 12 as more than an LGBTQ hate crime, but rather as emblematic of a battleground of a sacred space (Latin night at the gay bar) for queer bodies of color. The project establishes a more complex framework for understanding what took place on June 12 that can appreciate the ethno-racial, spiritual, and queer dimensions that foregrounded the event. I maintain that the method of analysis necessitates a different model of theorizing, one that can crystalize the sexuality of terrorism, the whiteness of homonationalism, and thereby the importance of creating sacred space for Latinx queer subjects, many of whom, in the context of June 12, form part of the Puerto Rican diaspora. (shrink)

A memoir of one womanÆs struggle against breast cancer reveals how she channeled her energy to transform her life, even as she was dying.

As professionals, nurses are engaged in a moral endeavour, and thus confront many challenges in making the right decision and taking the right action. When nurses cannot do what they think is right, they experience moral distress that leaves a moral residue. This article proposes a theory of moral distress and a research agenda to develop a better understanding of moral distress, how to prevent it, and, when it cannot be prevented, how to manage it.

This chapter argues that the best way for a non-naturalist to explain why the normative supervenes on the natural is to claim that, while there are some sui generis normative properties whose essences cannot be fully specified in non-normative terms and do not specify any non-normative sufficient conditions for their instantiation, there are certain hybrid normative properties whose essences specify both naturalistic sufficient conditions for their own instantiation and sufficient conditions for the instantiation of certain sui generis normative properties. This (...) is the only metaphysical explanation for supervenience on offer, the chapter argues, that can both clearly maintain the pre-theoretical commitments of non-naturalism, and provide a metaphysical explanation not just for supervenience, but for all metaphysical necessities involving natural and normative properties. (shrink)