Recent experimental evidence suggests that most of the genome is transcribed into non‐coding RNAs. The initial transcripts undergo further processing generating shorter, metabolically stable RNAs with diverse functions. Small nucleolar RNAs (snoRNAs) are non‐coding RNAs that modify rRNAs, tRNAs, and snRNAs that were considered stable. We review evidence that snoRNAs undergo further processing. High‐throughput sequencing and RNase protection experiments showed widespread expression of snoRNA fragments, known as snoRNA‐derived RNAs (sdRNAs). Some sdRNAs resemble miRNAs, these can associate with argonaute proteins and (...) influence translation. Other sdRNAs are longer, form complexes with hnRNPs and influence gene expression. C/D box snoRNA fragmentation patterns are conserved across multiple cell types, suggesting a processing event, rather than degradation. The loss of expression from genetic loci that generate canonical snoRNAs and processed snoRNAs results in diseases, such as Prader‐Willi Syndrome, indicating possible physiological roles for processed snoRNAs. We propose that processed snoRNAs acquire new roles in gene expression and represent a new class of regulatory RNAs distinct from canonical snoRNAs.Also watch the Video Abstract. (shrink)

The aim of this book is to present and analyze philosophical conceptions concerning mathematics and logic as formulated by Polish logicians, mathematicians and philosophers in the 1920s and 1930s. It was a remarkable period in the history of Polish science, in particular in the history of Polish logic and mathematics. Therefore, it is justified to ask whether and to what extent the development of logic and mathematics was accompanied by a philosophical reflection. We try to answer those questions by analyzing (...) both works of Polish logicians and mathematicians who have a philosophical temperament as well as their research practice. Works and philosophical views of the following Polish scientists will be analyzed: Wacław Sierpiński, Zygmunt Janiszewski, Stefan Mazurkiewicz, Stefan Banach Hugo Steinhaus, Eustachy Żylińsk and Leon Chwistek, Jan Łukasiewicz, Zygmunt Zawirski, Stanisław Leśniewski, Tadeusz Kotarbiński, Kazimierz Ajdukiewicz, Alfred Tarski, Andrzej Mostowski and Henryk Mehlberg, Jan Sleszyński, Stanisław Zaremba and Witold Wilkosz. To indicate the background of scientists being active in the 1920s and 1930s we consider in Chapter 1 some predecessors, in particular: Jan Śniadecki, Józef Maria Hoene-Wroński, Samuel Dickstein and Edward Stamm. (shrink)

The globalization movement in recent decades has meant rapid growth in trade, financial transactions, and cross-country ownership of economic assets. In this article, we examine how the globalization of national business systems has influenced the framing of corporate social responsibility (CSR). This is done using text analysis of CEO letters appearing in the annual reports of 15 major corporations in Sweden during a period of transformational change. The results show that the discourse about CSR in the annual reports has changed (...) from a national and communitarian view of social responsibility (cf. a negotiated view of CSR) toward an international and individualistic view of social responsibility (cf. a self-regulating view of CSR). The article contributes theoretically (1) by adding a national–global dimension to previous conceptualizations of CSR and (2) by showing that the rise of CSR discourse and activities in the last 10 years does not have to imply an increased commitment and interest in corporate responsibility per se, only that there are increased societal expectations that corporations should develop the capability to act more independently as moral agents. (shrink)

I am focusing here on the main counterarguments that were raised against a thesis I put forward in my article “Nietzsche, the Overhuman, and Transhumanism” (2009), namely that significant similarities can be found on a fundamental level between the concept of the posthuman, as put forward by some transhumanists, and Nietzsche’s concept of the overhuman. The articles with the counterarguments were published in the recent “Nietzsche and European Posthumanisms” issue of The Journal of Evolution and Technology (January-July 2010). As several (...) commentators referred to identical issues, I decided that it would be appropriate not to respond to each of the articles individually, but to focus on the central arguments and to deal with the counterarguments mentioned in the various replies. I am concerned with each topic in a separate section. The sections are entitled as follows: 1. Technology and evolution; 2. Overcoming nihilism; 3. Politics and liberalism; 4. Utilitarianism or virtue ethics?; 5. The good Life; 6. Creativity and the will to power; 7. Immortality and longevity; 8. Logocentrism; 9. The Third Reich. When dealing with the various topics, I am not merely responding to counterarguments; I also raise questions concerning transhumanism and put forward my own views concerning some of the questions I am dealing with. (shrink)

A computational model of inference during story comprehension is presented, in which story situations are represented distributively as points in a high‐dimensional “situation‐state space.” This state space organizes itself on the basis of a constructed microworld description. From the same description, causal/temporal world knowledge is extracted. The distributed representation of story situations is more flexible than Golden and Rumelhart's [Discourse Proc 16 (1993) 203] localist representation.A story taking place in the microworld corresponds to a trajectory through situation‐state space. During the (...) inference process, world knowledge is applied to the story trajectory. This results in an adjusted trajectory, reflecting the inference of propositions that are likely to be the case. Although inferences do not result from a search for coherence, they do cause story coherence to increase. The results of simulations correspond to empirical data concerning inference, reading time, and depth of processing.An extension of the model for simulating story retention shows how coherence is preserved during retention without controlling the retention process. Simulation results correspond to empirical data concerning story recall and intrusion. (shrink)

This systematic review identified and evaluated instruments measuring patients' perceptions of patient‐centred nursing care. Of 2629 studies reviewed, 12 were eligible for inclusion. Four instruments were reported: The Individualized Care Scale, the Client‐Centred Care Questionnaire, the Oncology patients' Perceptions of the Quality of Nursing Care Scale and the Smoliner scale. These instruments cover themes addressing patient participation and the clinician–patient relationship. Instruments were shown to have satisfactory psychometric properties, although not all were adequately assessed. More research is needed regarding test–retest (...) reliability, convergent and discriminant validity, validity with known groups and structural validity using confirmatory factor analysis. (shrink)

Topic of the paper is Q-logic – a logic of agency in its temporal and modal context. Q-logic may be considered as a basal logic of agency since the most important stit-operators discussed in the literature can be defined or axiomatized easily within its semantical and syntactical framework. Its basic agent dependent operator, the Q-operator (also known as Δ- or cstit-operator), which has been discussed independently by F. v. Kutschera and B. F. Chellas, is investigated here in respect of its (...) relation to other temporal and modal operators. The main result of the paper, then, is a completeness result for a calculus of Q-logic with respect to a semantics defined on the tree-approach to agency as introduced and developed by, among others, F. v. Kutschera and N. D. Belnap. (shrink)

This book offers a scientific whistleblower’s perspective on current implementation of federal research misconduct regulations. It provides a narrative of general interest that relates current cases of research ethics to philosophical, historical and sociological accounts of fraud in scientific research. The evidence presented suggests that the problems of falsification and fabrication remain as great as ever, but hidden because the current system puts universities in charge of investigations and permits them to use confidentiality regulations to hide the outcomes of investigations. (...) The book documents the significant conflict of interest that arises because federal regulation gives universities the responsibility to conduct investigations of their own faculty with severely limited oversight. The book is intended for young research scientists or anyone who wishes to understand the challenges faced by scientists in the workplace today. The central thread in the book is an exclusive account of an experienced research scientist who was the first to expose the facts that led to the longest running research misconduct investigation in the history of the National Science Foundation. (shrink)

This chapter provides an overview of Bernard Bolzano’s views about grounding. On Bolzano’s account, grounding is an objective priority relation among true propositions that has certain explanatory features. The chapter briefly highlights historical influences on Bolzano’s account of grounding and subsequently provides an overview of the most important aspects of it. Bolzano’s account resembles current accounts of metaphysical grounding in many respects and can thus easily be related to many positions in the current debate. The chapter investigates some Bolzanian ideas (...) about grounding that differ from the current orthodoxy but may constitute interesting additions, challenges or inspirations for those working in the current debate. It is striking that Bolzano accepts a number of principles that seem to be motivated by the same kind of intuition that underlies present work on the logic of ground. Bolzano’s thought is that, for instance, general mathematical truths will never be grounded in truths concerned with any individual concrete object in particular. (shrink)

The number of people with dementia is increasing worldwide. At the same time, family and professional caregivers’ resources are limited. A promising approach to relieve these carers’ burden and assist people with dementia is assistive technology. In order to be useful and accepted, such technologies need to respect the values and needs of their intended users. We applied the value sensitive design approach to identify values and needs of patients with dementia and family and professional caregivers in respect to assistive (...) technologies to assist people with dementia in institutionalized care. Based on semi-structured interviews of residents/patients with cognitive impairment, relatives, and healthcare professionals (10 each), we identified 44 values summarized by 18 core values. From these values, we created a values’ network to demonstrate the interplay between the values. The core of this network was caring and empathy as most strongly interacting value. Furthermore, we found 36 needs for assistance belonging to the four action fields of activity, care, management/administration, and nursing. Based on these values and needs for assistance, we created possible use cases for assistive technologies in each of the identified four action fields. All these use cases already are technologically feasible today but are not currently being used in healthcare facilities. This underlines the need for development of value-based technologies to ensure not only technological feasibility but also acceptance and implementation of assistive technologies. Our results help balance conflicting values and provide concrete suggestions for how engineers and designers can incorporate values into assistive technologies. (shrink)

Is there any good reason to believe in Nietzsche's metaphysics even thought he himself claims that it is not "the truth" in correspondence with the world? According to Danto, Nietzsche's metaphysics is only valid for Nietzsche himself. However, this answer does not take into consideration Nietzsche's claim for the general superiority of his philosophy. Nietzsche's view seems inconsistent: on the one hand, he claimed all perspectives are equally false in respect to "the truth," but on the other, he regarded his (...) view as superior. This book explains in which respect Nietzshe justifies his claims, that Nietzsche's position is not inconsistent, and why consistency is important for him. (shrink)

Two Sides of the Same Coin. Unpacking Rainer Forst’s Basic Right to Justification This paper makes two comments on Rainer Forst’s keynote contribution. It argues, first, that three important distinctions introduced by Forst are, in fact, all different versions of the more primary distinction between the a priori reconstruction of basic rights by philosophers and the discursive construction of basic rights by citizens. It proposes, secondly, an alternative discourse-theoretical reconstruction which makes a distinction between the basic right to justification and (...) the basic right to choose your own ends as two different but inseparable rights – two sides of the same coin – which jointly provide the moral ground for our basic rights as citizens. (shrink)

This paper investigates Bolzano’s views on the distinction between logical and non-logical notions. Even though it is crucial for Bolzano’s definitions of logical consequence and logical analyticity, his remarks on how the distinction is to be drawn are few and far between. Bolzano’s adherence to a traditional, pre-Fregean syntax, complicates interpreting these remarks even further. The paper offers an interpretation of the remarks on which they suggest that Bolzano identified logicality with topic-neutrality. It further discusses Bolzano’s views on the systematic (...) relevance of the notion of logical consequence. (shrink)

The search for ethical guidance in the development of artificial intelligence (AI) systems, especially in healthcare and decision support, remains a crucial effort. So far, principles usually serve as the main reference points to achieve ethically correct implementations. Based on reviewing classical criticism of principle-based ethics and taking into account the severity and potentially life-changing relevance of decisions assisted by AI-driven systems, we argue for strengthening a complementary perspective that focuses on the life-world as ensembles of practices which shape people’s (...) lives. This perspective focuses on the notion of ethical judgment sensitive to life forms, arguing that principles alone do not guarantee ethicality in a moral world that is rather a joint construction of reality than a matter of mere control. We conclude that it is essential to support and supplement the implementation of moral principles in the development of AI systems for decision-making in healthcare by recognizing the normative relevance of life forms and practices in ethical judgment. (shrink)

Drawing on the work of Robert Nozick and Johann Gottlieb Fichte, the author argues that human self-consciousness cannot be explained in naturalistic terms. Instead, it is a spontaneous phenomenon.

This is the first volume of essays on Berkeley's Three Dialogues, a classic of early modern philosophy. Leading experts cover all the central issues in the text: the rejection of material substance, the nature of perception and reality, the limits of human knowledge, and the perceived threats of skepticism, atheism, and immorality.

This survey paper pursues three aims. The first aim is to sketch the overall role that grounding plays in Bolzano’s philosophy and to indicate some historical roots of his views, namely Aristotle’s conception of scientific proofs and the rationalist’s debate about the Principle of Sufficient Reason. The second aim is to provide readers coming from the current debate about metaphysical grounding with an accessible overview of Bolzano’s mature conception of grounding. The third and final aim of the paper is to (...) introduce elements and terminology from Bolzano’s conceptual and ontological framework that are required to understand his theory of grounding. (shrink)

According to Kant, a true judgement can be called a priori in case it can take place absolutely (schlechterdings) independent of experience. Propositions that are knowable in this way are called a priori propositions by him (Kant 1787 B, 3–4). As is well known, the class of those a priori propositions that are synthetic was particularly important for Kant. In contrast to analytic propositions, they are supposed to contain nontrivial information about the world and yet be irrefutable by experience. Not (...) many of his critics were satisfied with Kant’s way of drawing this distinction. (shrink)

Sartre’s description of violence from his often-neglected Notebooks for an Ethics can be analyzed from a psychological point of view in relationship with other negative passions like hatred, fury, pain and sufferance. Literary characters such as Seneca’s Medea or Anouilh’s Antigone seem to embody this fundamental characteristic of violence: the alliance with an ontological striving for destruction. In this paper we provide an interpretation of the Sartrean portrait of the violent man, analyzing its connections with his existential doctrine from Being (...) and Nothingness, and its affinity with modern nihilism (Nietzsche and Cioran) and Gnostic dualism (Catharism and Manicheanism). (shrink)

Rashīd al-Dīn Ṭabīb (d. 1318) has been called the “first world historian” because of how foreign historical sources are treated in the second volume of his Jāmiʿ al-tawārīkh. New manuscript materials have shown, however, that his contemporary courtier and historian, ʿAbd Allāh Qāshānī, is likely the real author of much of the Jāmiʿ. This article advances the discussion about the creation of Jāmiʿ al-tawārīkh by describing and analyzing an alternate version of Rashīd al-Dīn’s introduction to the collection. This alternate introduction, (...) preserved in a single manuscript in Munich, suggests that Rashīd al-Dīn initially had a very different purpose in mind for his world history than what has come down to us, envisioning it not as an ecumenical description of the world but as a programmatic argument for his patrons’ sovereign legitimacy. Examining this alternate introduction forces us to rethink Rashīd al-Dīn’s historiographical motive. It also helps answer open questions about the structure of Jāmiʿ al-tawārīkh, its production, and how Qāshānī’s text came to be included in it. (shrink)

Performativity plays a significant role avant la lettre in Classical German Philosophy. It is, among other things, a central component of original interpretations of the Absolute, the Subject, and Knowledge. Since the 2010s, there has been an increasing number of studies examining the performative in Kant, Fichte, Schelling, Hegel, Kierkegaard, Hölderlin, Novalis, Schliermacher, and Schlegel. This anthology picks up on this development. Through interdisciplinary contributions, performativity within Classical German Philosophy is explained and discussed, highlighting the hermeneutic and systematic insights gained (...) from performative interpretations. [In German: Performativität spielt avant la lettre in der Klassischen Deutschen Philosophie eine bedeutende Rolle. Sie ist u.a. ein zentraler Bestandteil originärer Interpretationen des Absoluten, des Subjekts oder auch des Wissens. Seit den 2010er Jahren mehren sich daher Untersuchungen, die dem Performativen bei Kant, Fichte, Schelling, Hegel, Kierkegaard, Hölderlin, Novalis, Schliermacher, und Schlegel. Dieser Sammelband greift diese Entwicklung auf. Anhand interdisziplinärer Beiträge wird Performativität innerhalb der Klassischen Deutschen Philosophie erläutert und diskutiert. Dabei wird der hermeneutische und systematische Ertrag performativer Interpretationen dargestellt.]. (shrink)

Legal scholars, privacy advocates and major tech corporations all coalesce around one single idea. Data should be considered property. Legal analysts point to the ability of governments to regulate property, privacy advocates argue that personal rights would be better protected through a property model, and large tech companies want to claim ownership over data as a proprietary trade secret. I argue that the tendency to view data as property is a result of the long legacy of enlightenment philosophy surrounding property. (...) In particular, John Locke has a special hold on the public imaginary, and his twin concepts of self-ownership and the labor theory of accumulation lead us to conceptualize data as a special form of property. However, the property model of data has significant drawbacks. By commodifying data, we commodify ourselves and allow for colonial theories of enclosure to dominate the discourse. Instead, I propose an alternative framing of data, drawn from the work of Judith Butler, whose ideas allow us to see data as an extension of the performance of identity. Drawing on both Gender Trouble and Bodies that Matter I argue that viewing data as part of the performance of identity allows us to mitigate the harms of a property model and reconsider our relationship with our data. (shrink)

Adventure -- Call -- Brother paul -- Transgression -- Two loves -- Freedom -- Interlude -- Freedom again -- Between Heidegger and Derrida -- Dancing in the void -- The advent of weak theology -- Kingdom.

According to Humean promotionalism about practical reasons, the fact that I have a reason to φ holds in virtue of the fact that φ-ing promotes one or more of my desires. The topic of this discussion note is the question of how best to understand the promotion relation. In particular, I defend a probabilistic understanding of promotion against a line of argument recently brought forth by Jeff Behrends, Joshua DiPaolo, and Nate Sharadin. Roughly, their argument is that probabilistic promotion leads (...) to implausible results in cases in which the relevant desires are certain to be satisfied. In these cases, a probabilistic understanding tells us that we do not have a reason to φ because the probability of desire satisfaction is 1 already. Contrary to Behrends', DiPaolo's, and Sharadin's claims, I argue that this is precisely the result a Humean theory of reasons should generate. According to Humeanism, we have reasons for actions because these actions make a difference to the occurrence of desire satisfaction - where the causal route to desire satisfaction is normatively irrelevant. Thus, if desire satisfaction is dead certain, we have no reason to do anything. (shrink)

In this article I seek to explain Hegel’s significance to contemporary meta-ethics, in particular to Kantian constructivism. I argue that in the master–slave dialectic in the Phenomenology of Spirit, Hegel shows that self-consciousness and intersubjectivity arise at the same time. This point, I argue, shows that there is no problem with taking other people’s reasons to motivate us since reflection on our aims is necessarily also reflection on the needs of those around us. I further explore Hegel’s contribution to the (...) debate about internal and external reasons. I end by arguing that we should understand reasons as historically constructed in the sense that who counts as an intrinsic bearer of value changes over time. I thus argue that the struggle for recognition is in fact the beginning of the long march toward the idea of recognition and the Kantian kingdom of ends. This march, however, is driven by the need to overcome injustice as it is instantiated at the beginning of history by the master’s absolute domination of the slave. (shrink)

Der Artikel diskutiert Bolzanos Theorie der Abfolge (grounding). Im Mittelpunkt steht eine kritische Untersuchung der These Bolzanos, dass sich eine Vielzahl von Grund-Folge-Beziehungen auf die Beziehung der Abfolge zurückführen lassen.

Amsterdam University Press is a leading publisher of academic books, journals and textbooks in the Humanities and Social Sciences. Our aim is to make current research available to scholars, students, innovators, and the general public. AUP stands for scholarly excellence, global presence, and engagement with the international academic community.

Relativistic accounts of interpretation are widespread in literary studies. According to these accounts, interpretations of works of literature can, at best, be relatively valid. Aiming for objective validity, proponents of relativism say, is an intrinsically flawed approach to the interpretation of literature. The book offers a comprehensive analysis of relativistic theories of literary interpretation. It examines the different forms relativistic theories can take, presents the arguments that were given for their justification, and gives a critical assessment of these arguments. The (...) main part of the book discusses four of the most prevailing argumentative strategies in favor of interpretive relativism: deconstructive relativism, pragmatic relativism, alethic (or logical) relativism, and constructive relativism. These types of relativistic theories are examined through the examples of four actual, fleshed-out theories of interpretation proposed by Jacques Derrida and other deconstructionists, Stanley Fish, Joseph Margolis, and Michael Krausz. Their specific theories are scrutinized in great detail but with an overarching purpose: The study aims at highlighting general problems and difficulties connected to the different justifications for interpretive relativism. The last part of the book deals with a number of theses that enjoy some popularity in literary studies – common assumptions that at least under some reading may have relativistic consequences. In particular, the following theses are discussed: the claim that ‘every reader interprets her/his own text’; the claim that readers should not aim for ‘true’ interpretations but for interpretations that are ‘plausible’ (with plausibility being construed without any appeal to truth); and the claim that the validity of interpretations is, in a non-trivial sense, relativeto the different interpretive aims readers may pursue. Finally, the question is raised (and answered at least in broad outline) to what extent the well-known fact of a vast plurality of divergent and sometimes incompatible theories, approaches, and methods in literary studies has any relativistic implications. (shrink)

Starting from the question whether one has to assign Fichte and Jacobi to the Enlightenment movement, this paper makes the attempt to show that it is the categorical interest in the reality of reason, which is an at least necessary condition for characterizing a certain way of thinking as enlightening. At the center of the study stands the relationship of Jacobi and Fichte to Friedrich Nicolai and the Berlin Enlightenment. In this controversy, all thinkers share the very same interest, namely, (...) the interest in the reality of reason. But what distinguishes Fichte and Jacobi from Nicolai is the absoluteness of their interest in reason, scilicet an interest which is not induced by affects or needs exterior to reason. At the same time, the dispute addresses the relation between absoluteness and conditionality of reason itself. Both Fichte and Jacobi try to elaborate a critical notion of reason mediating between absoluteness and conditionality. Ausgehend von der Frage, ob Jacobi und Fichte der Aufklärung zuzuordnen sind, versucht der Artikel zu zeigen, dass das unbedingte Interesse an der Wirklichkeit der Vernunft eine wenn auch nicht hinreichende, so doch zumindest notwendige Bedingung für die Bezeichnung eines Denkens als aufklärerisch in einem systematischen Sinne ist. Im Zentrum der Untersuchung steht dabei das Verhältnis von Jacobi und Fichte zu Friedrich Nicolai und der Berliner Aufklärung. In ihrer Auseinandersetzung teilen alle Denker nämlich ein gemeinsames Interesse, und zwar das Interesse an der Wirklichkeit der Vernunft. Was Fichte und Jacobi aber von Nicolai unterscheidet, ist die Unbedingtheit ihres Interesses an der Vernunft – also ein Interesse, das nicht durch der Vernunft äußerliche Neigungen oder Bedürfnisse bedingt ist. Der Disput thematisiert dabei zugleich das Verhältnis von Bedingtheit und Unbedingtheit der Vernunft selbst. Fichte und Jacobi bringen jeweils einen zwischen Bedingtheit und Unbedingtheit vermittelnden kritischen Vernunftbegriff zur Geltung. (shrink)

In this article I attempt to find out the appropriate understanding of “liberal education”. Firstly, I distinguish the two most important meanings of the notion “freedom” which I call momentary and lifelong freedom. Momentary freedom is a type of negative freedom, and lifelong freedom a type of positive freedom. Secondly, I show the consequences, which these two meanings of “freedom” have on the practice of a “liberal education”. Finally, I analyse which type of liberal education is the best.

Auxin is a simple molecule but one with a complex and crucial influence on plant development. Accumulation and response to this important plant hormone underlies events as diverse as embryo patterning and growth responses to light and gravity. As such, research on auxin can be traced back to Darwin and has flourished into an immense body of work that has often had implications beyond plant biology. The latest instalment of the auxin story is no different:(1) the solution of the crystal (...) structure of the auxin receptor TIR1 illustrates, in spectacular detail, precisely how auxin is perceived and provides an insight into the working of a new class of receptor, which seems likely to be the first example of a new paradigm in eukaryotic signal transduction. BioEssays 29:953–956, 2007. © 2007 Wiley Periodicals, Inc. (shrink)