Recent experimental evidence suggests that most of the genome is transcribed into non‐coding RNAs. The initial transcripts undergo further processing generating shorter, metabolically stable RNAs with diverse functions. Small nucleolar RNAs (snoRNAs) are non‐coding RNAs that modify rRNAs, tRNAs, and snRNAs that were considered stable. We review evidence that snoRNAs undergo further processing. High‐throughput sequencing and RNase protection experiments showed widespread expression of snoRNA fragments, known as snoRNA‐derived RNAs (sdRNAs). Some sdRNAs resemble miRNAs, these can associate with argonaute proteins and (...) influence translation. Other sdRNAs are longer, form complexes with hnRNPs and influence gene expression. C/D box snoRNA fragmentation patterns are conserved across multiple cell types, suggesting a processing event, rather than degradation. The loss of expression from genetic loci that generate canonical snoRNAs and processed snoRNAs results in diseases, such as Prader‐Willi Syndrome, indicating possible physiological roles for processed snoRNAs. We propose that processed snoRNAs acquire new roles in gene expression and represent a new class of regulatory RNAs distinct from canonical snoRNAs.Also watch the Video Abstract. (shrink)

The aim of this book is to present and analyze philosophical conceptions concerning mathematics and logic as formulated by Polish logicians, mathematicians and philosophers in the 1920s and 1930s. It was a remarkable period in the history of Polish science, in particular in the history of Polish logic and mathematics. Therefore, it is justified to ask whether and to what extent the development of logic and mathematics was accompanied by a philosophical reflection. We try to answer those questions by analyzing (...) both works of Polish logicians and mathematicians who have a philosophical temperament as well as their research practice. Works and philosophical views of the following Polish scientists will be analyzed: Wacław Sierpiński, Zygmunt Janiszewski, Stefan Mazurkiewicz, Stefan Banach Hugo Steinhaus, Eustachy Żylińsk and Leon Chwistek, Jan Łukasiewicz, Zygmunt Zawirski, Stanisław Leśniewski, Tadeusz Kotarbiński, Kazimierz Ajdukiewicz, Alfred Tarski, Andrzej Mostowski and Henryk Mehlberg, Jan Sleszyński, Stanisław Zaremba and Witold Wilkosz. To indicate the background of scientists being active in the 1920s and 1930s we consider in Chapter 1 some predecessors, in particular: Jan Śniadecki, Józef Maria Hoene-Wroński, Samuel Dickstein and Edward Stamm. (shrink)

We present the first comprehensive theory of fairness that conceives of fairness as having two dimensions: a comparative and an absolute one. The comparative dimension of fairness has traditionally been the main interest of Broomean fairness theories. It has been analysed as satisfying competing individual claims in proportion to their respective strengths. And yet, many key contributors to Broomean fairness agree that ‘absolute’ fairness is important as well. We make this concern precise by introducing the Fairness formula and the absolute (...) priority rule and analyse their implications for comparative fairness. (shrink)

Machine learning is used more and more in scientific contexts, from the recent breakthroughs with AlphaFold2 in protein fold prediction to the use of ML in parametrization for large climate/astronomy models. Yet it is unclear whether we can obtain scientific explanations from such models. I argue that when machine learning is used to conduct causal inference we can give a new positive answer to this question. However, these ML models are purpose-built models and there are technical results showing that standard (...) machine learning models cannot be used for the same type of causal inference. Instead, there is a pathway to causal explanations from predictive ML models through new explainability techniques; specifically, new methods to extract structural equation models from such ML models. The extracted models are likely to suffer from issues though: they will often fail to account for confounders and colliders, as well as deliver simply incorrect causal graphs due to ML models tendency to violate physical laws such as the conservation of energy. In this case, extracted graphs are a starting point for new explanations, but predictive accuracy is no guarantee for good explanations. (shrink)

In the article ‘How to be absolutely fair, Part I: the Fairness formula’, we presented the first theory of comparative and absolute fairness. Here, we relate the implications of our Fairness formula to economic theories of fair division. Our analysis makes contributions to both philosophy and economics: to the philosophical literature, we add an axiomatic discussion of proportionality and fairness. To the economic literature, we add an appealing normative theory of absolute and comparative fairness that can be used to evaluate (...) axioms and division rules. Also, we provide a novel definition and characterization of the absolute priority rule. (shrink)

This paper critically compares a deliberative system based on parliamentary elections (an electoral system) and a deliberative system based on sortition (a lottocratic system). Both systems are analyzed in three dimensions. The epistemic dimension concerns the rational quality of the democratic process. The power dimension concerns the distribution of power and the extent to which citizens genuinely control all decisions. The motivational dimension, finally, concerns citizens’ identification with the decision-making process and their willingness to abide by its outcomes. We argue (...) that an electoral system is, in all three dimensions, normatively superior to a sortition-based system. Most prominently, we claim that electoral mechanisms provide visibility to the decision-making process. This enables a form of interactive representation in which citizens and their representatives engage in a joint process of opinion and will formation. Sortition, in contrast, is characterized by a democratically much poorer form of descriptive representation. The selected citizens are a representative sample of the wider citizenry, but they deliberate in a forum that remains mostly disconnected from that wider citizenry and therefore cannot shoulder the process of collective self-government. (shrink)

An English double-embedded relative clause from which the middle verb is omitted can often be processed more easily than its grammatical counterpart, a phenomenon known as the grammaticality illusion. This effect has been found to be reversed in German, suggesting that the illusion is language specific rather than a consequence of universal working memory constraints. We present results from three self-paced reading experiments which show that Dutch native speakers also do not show the grammaticality illusion in Dutch, whereas both German (...) and Dutch native speakers do show the illusion when reading English sentences. These findings provide evidence against working memory constraints as an explanation for the observed effect in English. We propose an alternative account based on the statistical patterns of the languages involved. In support of this alternative, a single recurrent neural network model that is trained on both Dutch and English sentences is shown to predict the cross-linguistic difference in the grammaticality effect. (shrink)

I am focusing here on the main counterarguments that were raised against a thesis I put forward in my article “Nietzsche, the Overhuman, and Transhumanism” (2009), namely that significant similarities can be found on a fundamental level between the concept of the posthuman, as put forward by some transhumanists, and Nietzsche’s concept of the overhuman. The articles with the counterarguments were published in the recent “Nietzsche and European Posthumanisms” issue of The Journal of Evolution and Technology (January-July 2010). As several (...) commentators referred to identical issues, I decided that it would be appropriate not to respond to each of the articles individually, but to focus on the central arguments and to deal with the counterarguments mentioned in the various replies. I am concerned with each topic in a separate section. The sections are entitled as follows: 1. Technology and evolution; 2. Overcoming nihilism; 3. Politics and liberalism; 4. Utilitarianism or virtue ethics?; 5. The good Life; 6. Creativity and the will to power; 7. Immortality and longevity; 8. Logocentrism; 9. The Third Reich. When dealing with the various topics, I am not merely responding to counterarguments; I also raise questions concerning transhumanism and put forward my own views concerning some of the questions I am dealing with. (shrink)

A computational model of inference during story comprehension is presented, in which story situations are represented distributively as points in a high‐dimensional “situation‐state space.” This state space organizes itself on the basis of a constructed microworld description. From the same description, causal/temporal world knowledge is extracted. The distributed representation of story situations is more flexible than Golden and Rumelhart's [Discourse Proc 16 (1993) 203] localist representation.A story taking place in the microworld corresponds to a trajectory through situation‐state space. During the (...) inference process, world knowledge is applied to the story trajectory. This results in an adjusted trajectory, reflecting the inference of propositions that are likely to be the case. Although inferences do not result from a search for coherence, they do cause story coherence to increase. The results of simulations correspond to empirical data concerning inference, reading time, and depth of processing.An extension of the model for simulating story retention shows how coherence is preserved during retention without controlling the retention process. Simulation results correspond to empirical data concerning story recall and intrusion. (shrink)

This systematic review identified and evaluated instruments measuring patients' perceptions of patient‐centred nursing care. Of 2629 studies reviewed, 12 were eligible for inclusion. Four instruments were reported: The Individualized Care Scale, the Client‐Centred Care Questionnaire, the Oncology patients' Perceptions of the Quality of Nursing Care Scale and the Smoliner scale. These instruments cover themes addressing patient participation and the clinician–patient relationship. Instruments were shown to have satisfactory psychometric properties, although not all were adequately assessed. More research is needed regarding test–retest (...) reliability, convergent and discriminant validity, validity with known groups and structural validity using confirmatory factor analysis. (shrink)

Topic of the paper is Q-logic – a logic of agency in its temporal and modal context. Q-logic may be considered as a basal logic of agency since the most important stit-operators discussed in the literature can be defined or axiomatized easily within its semantical and syntactical framework. Its basic agent dependent operator, the Q-operator (also known as Δ- or cstit-operator), which has been discussed independently by F. v. Kutschera and B. F. Chellas, is investigated here in respect of its (...) relation to other temporal and modal operators. The main result of the paper, then, is a completeness result for a calculus of Q-logic with respect to a semantics defined on the tree-approach to agency as introduced and developed by, among others, F. v. Kutschera and N. D. Belnap. (shrink)

The standard argument for longtermism assumes that we should care as much about far future people as about our contemporaries. I challenge this assumption. I first consider existing interpretations of ‘temporal discounting’, and argue that such discounting seems either unwarranted or insufficient to block the argument. I then offer two alternative reasons to care less about far future people: caring as much about them as about our contemporaries would make our lives less authentic and less meaningful. If I’m right, this (...) undermines at least the strongest versions of longtermism. Plausibly, we should do much more for the far future than we’re currently doing. Still, we often ought to act for contemporaries’ sakes, even if longtermist actions would expectably do more good. (shrink)

This book offers a scientific whistleblower’s perspective on current implementation of federal research misconduct regulations. It provides a narrative of general interest that relates current cases of research ethics to philosophical, historical and sociological accounts of fraud in scientific research. The evidence presented suggests that the problems of falsification and fabrication remain as great as ever, but hidden because the current system puts universities in charge of investigations and permits them to use confidentiality regulations to hide the outcomes of investigations. (...) The book documents the significant conflict of interest that arises because federal regulation gives universities the responsibility to conduct investigations of their own faculty with severely limited oversight. The book is intended for young research scientists or anyone who wishes to understand the challenges faced by scientists in the workplace today. The central thread in the book is an exclusive account of an experienced research scientist who was the first to expose the facts that led to the longest running research misconduct investigation in the history of the National Science Foundation. (shrink)

Is there any good reason to believe in Nietzsche's metaphysics even thought he himself claims that it is not "the truth" in correspondence with the world? According to Danto, Nietzsche's metaphysics is only valid for Nietzsche himself. However, this answer does not take into consideration Nietzsche's claim for the general superiority of his philosophy. Nietzsche's view seems inconsistent: on the one hand, he claimed all perspectives are equally false in respect to "the truth," but on the other, he regarded his (...) view as superior. This book explains in which respect Nietzshe justifies his claims, that Nietzsche's position is not inconsistent, and why consistency is important for him. (shrink)

Este manuscrito inédito corresponde al capítulo final del libro _Latin America replies to Transhumanism. __A Symposium on Sorgner’s We have always been cyborgs _a publicarse el año 2024 por la editorial Trivent. Budapest, Hungria. Agradecemos a Stefan L. Sorgner y Teodora C. Artimon por los permisos de publicación. Las referencias a los autores mencionados corresponden a otros capítulos de este mismo libro. Traducción de Nicolás Rojas Cortés y Camilo Vergara Ramírez.

So-called Neo-Russellians, such as Salmon, Braun, Crimmins, and Perry, hold that the semantic content of ‘ n is F ’ in a context c is the singular proposition ⟨ o, P ⟩, where o is the referent of the name n in c, and P is the property expressed by the predicate F in c. This is also known as the Neo-Russellian theory. Using truth ascriptions with names designating propositions, such as ‘Goldbach's conjecture’, in this paper, I will argue that, (...) together with highly plausible principles regarding a priori knowledge, the Neo-Russellian theory leads to unacceptable consequences. I will call this ‘the Goldbach puzzle’. Since the solution to the Goldbach puzzle cannot be to reject the discussed principles regarding a priori knowledge, the puzzle will undermine the Neo-Russellian theory. (shrink)

Two Sides of the Same Coin. Unpacking Rainer Forst’s Basic Right to Justification This paper makes two comments on Rainer Forst’s keynote contribution. It argues, first, that three important distinctions introduced by Forst are, in fact, all different versions of the more primary distinction between the a priori reconstruction of basic rights by philosophers and the discursive construction of basic rights by citizens. It proposes, secondly, an alternative discourse-theoretical reconstruction which makes a distinction between the basic right to justification and (...) the basic right to choose your own ends as two different but inseparable rights – two sides of the same coin – which jointly provide the moral ground for our basic rights as citizens. (shrink)

Ludwig Wittgenstein ist zweifellos einer der bedeutendsten und einflussreichsten Philosophen des 20. Jahrhunderts – und das, obwohl er zu Lebzeiten kaum etwas veröffentlicht hat. Bis heute wirken der Stil seines Philosophierens und seine Radikalität auf viele philosophisch außerordentlich inspirierend. Hinzu kommt das Schillernde seiner von Anekdoten umrankten Persönlichkeit, die in etlichen biographischen Werken aufgearbeitet wurde. Stefan Majetschak gibt einen konzisen Überblick über Leben und Gesamtwerk dieser Jahrhundertfigur und spürt ihren Wirkungen nach.

Recent developments in the field of artificial intelligence (AI) present profound challenges for law. These challenges stem from law’s anthropocentrism, which is often left unspoken. This essay examines both the epistemic and normative dimensions of anthropocentrism within German Law, with a focus on Private Law. It defends the proposition that law’s anthropocentrism does not inherently oppose the idea of granting AI some form of legal capacity. Rather, so the essay argues, it is essentially a question of regulatory prudence to determine (...) the conditions and criteria under which the law should grant a legal status, legal capacity, or partial legal capacity to AI entities. Nonetheless, it is crucial to acknowledge that the core principles of private law as well as questions of liability for fault and negligence are rooted in human agency and cannot be directly applied to AI. It will be argued that the legal discourse on the recognition of AI is to be understood as a fundamentally political discourse. The political dimension of that discourse will be analyzed through the lens of the political theories of Hannah Arendt and Jaques Rancière, among others. (shrink)

Drawing on the work of Robert Nozick and Johann Gottlieb Fichte, the author argues that human self-consciousness cannot be explained in naturalistic terms. Instead, it is a spontaneous phenomenon.

This is the first volume of essays on Berkeley's Three Dialogues, a classic of early modern philosophy. Leading experts cover all the central issues in the text: the rejection of material substance, the nature of perception and reality, the limits of human knowledge, and the perceived threats of skepticism, atheism, and immorality.

This article discusses the influence that Schopenhauer’s thought had on Mihai Eminescu’s work with reference to the idea of “pessimism.” It also considers Schopenhauer’s influence on Romanian philosophy and literature at the end of the nineteenth century. We shall examine Eminescu’s alleged “Schopenhauerian pessimism,” considering firstly “pessimism” as a part of Eminescu’s “myth.” Secondly, we shall cover the critical reception of Eminescu’s “Schopenhauerian pessimism,” discussing the existing literary and philosophical scholarship. Finding that there are issues for debate regarding Schopenhauer’s alleged (...) influence upon Eminescu, we argue that Eminescu’s “Schopenhauerian pessimism” may be a “legend.” The article examines the connection between Eminescu and one of Schopenhauer’s most influential followers, Eduard von Hartmann. (shrink)

In this essay, I develop a moderate hierarchical position about the moral status of animals that is based on two factors: on the level of mental development of a being who is affected and on the significance of the interests that are affected. I argue that this view accommodates two different sets of moral intuitions. On one hand, it explains why, in general, humans have the special moral standing that is typically attributed to us. On the other hand, it also (...) allows us to accommodate much of our intuition about how animals ought to be treated. In addition, this view is supported also by plausible general theoretical considerations. Subsequently, I explore some implications of this view for some real-life examples of our interactions with animals, especially, for the practice of raising them for food using industrial methods. I argue that this practice is morally wrong and that the correct approach is to adopt a (nearly) plant-based lifestyle. (shrink)

According to Humean promotionalism about practical reasons, the fact that I have a reason to φ holds in virtue of the fact that φ-ing promotes one or more of my desires. The topic of this discussion note is the question of how best to understand the promotion relation. In particular, I defend a probabilistic understanding of promotion against a line of argument recently brought forth by Jeff Behrends, Joshua DiPaolo, and Nate Sharadin. Roughly, their argument is that probabilistic promotion leads (...) to implausible results in cases in which the relevant desires are certain to be satisfied. In these cases, a probabilistic understanding tells us that we do not have a reason to φ because the probability of desire satisfaction is 1 already. Contrary to Behrends', DiPaolo's, and Sharadin's claims, I argue that this is precisely the result a Humean theory of reasons should generate. According to Humeanism, we have reasons for actions because these actions make a difference to the occurrence of desire satisfaction - where the causal route to desire satisfaction is normatively irrelevant. Thus, if desire satisfaction is dead certain, we have no reason to do anything. (shrink)

In this article I seek to explain Hegel’s significance to contemporary meta-ethics, in particular to Kantian constructivism. I argue that in the master–slave dialectic in the Phenomenology of Spirit, Hegel shows that self-consciousness and intersubjectivity arise at the same time. This point, I argue, shows that there is no problem with taking other people’s reasons to motivate us since reflection on our aims is necessarily also reflection on the needs of those around us. I further explore Hegel’s contribution to the (...) debate about internal and external reasons. I end by arguing that we should understand reasons as historically constructed in the sense that who counts as an intrinsic bearer of value changes over time. I thus argue that the struggle for recognition is in fact the beginning of the long march toward the idea of recognition and the Kantian kingdom of ends. This march, however, is driven by the need to overcome injustice as it is instantiated at the beginning of history by the master’s absolute domination of the slave. (shrink)

Recent developments regarding the pharmacology of psychoactive substances are significant for treating depressions or opioid addictions. Current theories, hypotheses, and models of drug effects assume a cause–effect narrative, which is based on a stimulus/response mechanism. These narratives prioritize effects rather than conscious experiences. In this sense, drug experiences are quickly subsumed into common categories and codes of biological determinism. If subjective experiences are in the focus of the research, it quickly becomes a link to mystical, spiritual, or transcendental narratives. These (...) classifications lead to epistemological doublets (Gadamer). In this article, psychedelic experiences of drug users are analyzed in the frame of the pharmaco-analysis by Deleuze/Guattari. These framed psychedelic experiences are interpreted by means of a non-philosophical approach through philo-fictions (Laruelle), i.e., contradictory assumptions and hyperspeculations. In this respect, the aim of this article is to bring philo-fictions in relation to psychedelic experiences and to discuss them with models of information science, quantum mechanics, new materialism, and the philosophy of immanence. The result will be an open synthesis, with the assumption of further reflections on the agency, immanence, and the wholeness of matter. (shrink)

In contemporary art, a growing number of artists experiment with non-humans in their actual artworks. This paper examines the issues related to such practices with reference to Jakob von Uexküll’s analyses of the configuration of meaningful worlds by non-human animals, as well as Merleau-Ponty’s and Deleuze-Guattari’s interpretations of Uexküll’s ideas. Uexküll maintained that every living being lives in a world with meaning; Merleau-Ponty understood this claim as situating the beginning of culture in the creativity of non-humans; Deleuze and Guattari emphasized (...) the melodic and rhythmic dimension of this creativity, mainly interpreted as territorialization processes. These elements are paramount to understanding what is at stake with artworks featuring non-humans: considering projects proposals from Agnes Meyer-Brandis, Tomas Saraceno, Ana Maria Lopez Gomez and other contemporary artists, the conclusion is that an artwork featuring an encounter between two territorializing movements has the potential to transform the human range of perception. (shrink)

Sprache kann auf äußerst destruktive Weise verwendet werden. Ein Beispiel hierfür ist die Verwendung so genannter Slurs. Slurs sind sprachliche Ausdrücke, die Gruppen und deren individuelle Mitglieder aufgrund ihrer Herkunft, Ethnizität, Religion, sexueller Orientierung etc. abwerten. In den letzten 20 Jahren haben sich Sprachphilosoph*innen zunehmend mit den Fragen beschäftigt, wie anhand von Slurs abgewertet und was dadurch bewirkt wird. Die Beschäftigung mit diesen Fragen ist nicht nur theoretisch-sprachphilosophisch relevant. Ein besseres Verständnis davon, wie anhand von Slurs abgewertet wird, ist auch (...) von praktisch-ethischer Relevanz. Wenn wir verstehen, wie Slurs funktionieren, dann können wir auch verstehen, wie wir die negativen Konsequenzen ihrer Verwendung verhindern bzw. zumindest eindämmen können. In diesem Beitrag werden wir die abwertende Kraft von Slurs sowohl von theoretisch-sprachphilosophischer Seite her als auch unter dem Gesichtspunkt ethisch-praktischer Fragen beleuchten. (shrink)

This article reviews Theorie und Praxis in der Philosophie der Antike. Demokrit, die Sokratiker, Platon und Aristoteles 978-3-7705-6393-7.

In assessing the welfare of dairy cows and laying hens, longevity has recently been introduced as an indicator. This paper presents recent attempts to transfer the normative power of longevity to non-human animals and evaluates this choice systematically. It first shows that the normative power of longevity can be justified by utilitarianism but not by rights-based approaches. The case of the ban to kill day-old chicks in Germany is then used to show that public opinion leans neither to the utilitarian (...) approach nor to the rights-based one but draws a firm line between killing animals before and after reaching an adult age. This may be not so much a desire for longevity among farmed animals but a first sign of empathy that may transform our relationship with farmed animals. (shrink)

In this article I attempt to find out the appropriate understanding of “liberal education”. Firstly, I distinguish the two most important meanings of the notion “freedom” which I call momentary and lifelong freedom. Momentary freedom is a type of negative freedom, and lifelong freedom a type of positive freedom. Secondly, I show the consequences, which these two meanings of “freedom” have on the practice of a “liberal education”. Finally, I analyse which type of liberal education is the best.

Among legal scholars, P. J. A. Feuerbach is considered one of the most important German jurists of the 19th century: not only has he established Germany’s modern doctrine of penal law and the Bavarian penal code of 1813, but he is also the founder of the theory of psychological force, i.e. the idea of the threat of punishment (not punishment itself!) as deterrence. Whereas one cannot comprehend Feuerbach’s legal doctrines without their original philosophical justification, namely his concept of the legal (...) subject as a citizen of two worlds, most contemporary interpreters ignore this aspect of Feuerbach’s theory of punishment. Against this reductionist interpretation of Feuerbach, by reconstructing his philosophy of punishment, this article exposes both the theoretical potential and shortcomings of Feuerbach’s main philosophical concepts. (shrink)

Auxin is a simple molecule but one with a complex and crucial influence on plant development. Accumulation and response to this important plant hormone underlies events as diverse as embryo patterning and growth responses to light and gravity. As such, research on auxin can be traced back to Darwin and has flourished into an immense body of work that has often had implications beyond plant biology. The latest instalment of the auxin story is no different:(1) the solution of the crystal (...) structure of the auxin receptor TIR1 illustrates, in spectacular detail, precisely how auxin is perceived and provides an insight into the working of a new class of receptor, which seems likely to be the first example of a new paradigm in eukaryotic signal transduction. BioEssays 29:953–956, 2007. © 2007 Wiley Periodicals, Inc. (shrink)