Recent experimental evidence suggests that most of the genome is transcribed into non‐coding RNAs. The initial transcripts undergo further processing generating shorter, metabolically stable RNAs with diverse functions. Small nucleolar RNAs (snoRNAs) are non‐coding RNAs that modify rRNAs, tRNAs, and snRNAs that were considered stable. We review evidence that snoRNAs undergo further processing. High‐throughput sequencing and RNase protection experiments showed widespread expression of snoRNA fragments, known as snoRNA‐derived RNAs (sdRNAs). Some sdRNAs resemble miRNAs, these can associate with argonaute proteins and (...) influence translation. Other sdRNAs are longer, form complexes with hnRNPs and influence gene expression. C/D box snoRNA fragmentation patterns are conserved across multiple cell types, suggesting a processing event, rather than degradation. The loss of expression from genetic loci that generate canonical snoRNAs and processed snoRNAs results in diseases, such as Prader‐Willi Syndrome, indicating possible physiological roles for processed snoRNAs. We propose that processed snoRNAs acquire new roles in gene expression and represent a new class of regulatory RNAs distinct from canonical snoRNAs.Also watch the Video Abstract. (shrink)

The aim of this book is to present and analyze philosophical conceptions concerning mathematics and logic as formulated by Polish logicians, mathematicians and philosophers in the 1920s and 1930s. It was a remarkable period in the history of Polish science, in particular in the history of Polish logic and mathematics. Therefore, it is justified to ask whether and to what extent the development of logic and mathematics was accompanied by a philosophical reflection. We try to answer those questions by analyzing (...) both works of Polish logicians and mathematicians who have a philosophical temperament as well as their research practice. Works and philosophical views of the following Polish scientists will be analyzed: Wacław Sierpiński, Zygmunt Janiszewski, Stefan Mazurkiewicz, Stefan Banach Hugo Steinhaus, Eustachy Żylińsk and Leon Chwistek, Jan Łukasiewicz, Zygmunt Zawirski, Stanisław Leśniewski, Tadeusz Kotarbiński, Kazimierz Ajdukiewicz, Alfred Tarski, Andrzej Mostowski and Henryk Mehlberg, Jan Sleszyński, Stanisław Zaremba and Witold Wilkosz. To indicate the background of scientists being active in the 1920s and 1930s we consider in Chapter 1 some predecessors, in particular: Jan Śniadecki, Józef Maria Hoene-Wroński, Samuel Dickstein and Edward Stamm. (shrink)

Explanatory realism is the view that explanations work by providing information about relations of productive determination such as causation or grounding. The view has gained considerable popularity in the last decades, especially in the context of metaphysical debates about non-causal explanation. What makes the view particularly attractive is that it fits nicely with the idea that not all explanations are causal whilst avoiding an implausible pluralism about explanation. Another attractive feature of the view is that it allows explanation to be (...) a partially epistemic, context-dependent phenomenon. In spite of its attractiveness, explanatory realism has recently been subject to criticism. In particular, Taylor :197–219, 2018). has presented four types of explanation that the view allegedly cannot account for. This paper defends explanatory realism against Taylor’s challenges. We will show that Taylor’s counterexamples are either explanations that turn out to provide information about entities standing in productive determination relations or that they are not genuine explanations in the first place. (shrink)

According to the standard account of forgiveness, you forgive your wrongdoer by overcoming your resentment towards them. But how exactly must you do so? And when is such overcoming fitting? The aim of this paper is to introduce a novel version of the standard account to answer these questions. Its core idea is that the reactive attitudes are a fitting response not just to someone’s blameworthiness, but to their blameworthiness being significant for you, or worthy of your caring, in virtue (...) of your relationship to it. Someone’s blameworthiness is significant for you to the extent you’re bound up with what grounds it––e.g. with the wrongdoer’s being a participant in human relationships, with their attitudes, or with the victim’s being a source of demands. So you may fittingly not care about someone’s blameworthiness if it’s sufficiently insignificant for you in this manner––e.g. if their wrong happened far off in place and time. And forgiveness revolves around this. You forgive your wrongdoer if and only if, partly out of goodwill towards them, you cease to care about their blameworthiness––a bit as if their wrong had happened far off. If I’m right, this agent-relativity-based account can resolve the apparent ‘paradoxy of forgiveness’, satisfies a number of desiderata, and is plausible on an intuitive level. (shrink)

Against content theories of slurs, according to which slurs have some kind of derogatory content, Anderson and Lepore have objected that they cannot explain that even slurs under quotation can cause offense. If slurs had some kind of derogatory content, the argument goes, quotation would render this content inert and, thus, quoted slurs should not be offensive. Following this, Anderson and Lepore propose that slurs are offensive because they are prohibited words. In this paper, we will show that, pace Anderson (...) and Lepore, content theories of slurs do provide an explanation of the fact that quoted slurs can cause offense: even under quotation, the explanation goes, the derogatory content of a slur can still be psychologically efficacious. We will go one step further by pointing out that offensiveness is not the only function of slurs, but that slurs can also be used to create and reinforce negative attitudes towards the target group. While content theories can easily explain this by referring to some kind of derogatory content, Anderson and Lepore’s prohibitionism will lack a satisfactory explanation of this second function of slurs. Concluding, we will argue that, unlike uses of slurs, uses of quoted slurs normally do not derogate the target group. This will again speak in favor of content theories. Accordingly, uses of quoted slurs are not derogatory because quotation renders the derogatory content inert. Hence, rather than speaking against content theories, quoted slurs speak in their favor. (shrink)

Links between musicality and vocal emotion perception skills have only recently emerged as a focus of study. Here we review current evidence for or against such links. Based on a systematic literature search, we identified 33 studies that addressed either (a) vocal emotion perception in musicians and nonmusicians, (b) vocal emotion perception in individuals with congenital amusia, (c) the role of individual differences (e.g., musical interests, psychoacoustic abilities), or (d) effects of musical training interventions on both the normal hearing population (...) and cochlear implant users. Overall, the evidence supports a link between musicality and vocal emotion perception abilities. We discuss potential factors moderating the link between emotions and music, and possible directions for future research. (shrink)

The normative mechanics of promising seem complex. The strength and content of promissory obligations, and the residual duties they entail upon being violated, have various prima facie surprising features. We give an account to explain these features. Promises have a point. The point of a promise to φ is a promise-independent reason to φ for the promisee’s sake. A promise turns this reason into a duty. This explains the mechanics of promises. And it grounds a nuanced picture of immoral promises, (...) an argument against promissory bare wrongings, and a constraint on theories of why we have promissory obligations at all. (shrink)

Nietzsche’s texts contain a puzzle about the role of vulnerability in the creation of intimacy and its function on behalf of human flourishing. I describe the interpretive puzzle and its prima facie paradoxical aspects. On the one hand, there are texts in which Nietzsche expresses a longing for intimacy and other texts where he furnishes details about the possibility of intimacy between equals. On the other hand, Nietzsche is severely critical of certain types of intimacy and advocates for a pathos (...) of distance in human relationships. I claim that Nietzschean intimacy is not an inherently paradoxical concept. A proper understanding of Nietzsche’s anti-humanism provides the resources to resolve the paradox and to use the solution of the puzzle to illuminate Nietzsche’s insights about human psychology. (shrink)

When beliefs are quantified as credences, they are related to each other in terms of closeness and accuracy. The “accuracy first” approach in formal epistemology wants to establish a normative account for credences based entirely on the alethic properties of the credence: how close it is to the truth. To pull off this project, there is a need for a scoring rule. There is widespread agreement about some constraints on this scoring rule, but not whether a unique scoring rule stands (...) above the rest. The Brier score equips credences with a structure similar to metric space and induces a “geometry of reason.” It enjoys great popularity in the current debate. I point out many of its weaknesses in this article. An alternative approach is to reject the geometry of reason and accept information theory in its stead. Information theory comes fully equipped with an axiomatic approach which covers probabilism, standard conditioning, and Jeffrey conditioning. It is not based on an underlying topology of a metric space, but uses a non-commutative divergence instead of a symmetric distance measure. I show that information theory, despite initial promise, also fails to accommodate basic epistemic intuitions; and speculate on its remediation. (shrink)

In analytic philosophy, the concept of trust is often considered primarily to be a three-place relation between trustor, trustee, and the domain of trust. The analysis of trust is unsatisfactory, however, if such a relationship is derivative of other forms of trust, and consequently the analysis has only succeeded in explaining a particular branch of trust rather than explaining the root. Annette Baier considers a climate of trust, with all the moral perils of intimacy, explanatorily superior to contract-based, rational trust (...) between non-intimate equals in modern Western philosophy and thus provides an example of how the traditional analytic model is problematic. In this paper, I propose another account on which the conventional three-place trust relationship investigated in analytic philosophy is derivative. Based on Heidegger's fundamental ontology, humans are constitutively hermeneutic. If Heidegger's fundamental ontology or a similar hermeneutic anthropology is accepted, then trust relationships between humans are explanatorily subordinated to trust relationships between readers and texts rather than the other way around, as traditional accounts suggest. This reversal has a significant impact not only on our analysis of trust, but also on moral theory, personal identity, and scientific method. My paper details both the reversal in explanatory primacy and the implications for these philosophical disciplines. (shrink)

An English double-embedded relative clause from which the middle verb is omitted can often be processed more easily than its grammatical counterpart, a phenomenon known as the grammaticality illusion. This effect has been found to be reversed in German, suggesting that the illusion is language specific rather than a consequence of universal working memory constraints. We present results from three self-paced reading experiments which show that Dutch native speakers also do not show the grammaticality illusion in Dutch, whereas both German (...) and Dutch native speakers do show the illusion when reading English sentences. These findings provide evidence against working memory constraints as an explanation for the observed effect in English. We propose an alternative account based on the statistical patterns of the languages involved. In support of this alternative, a single recurrent neural network model that is trained on both Dutch and English sentences is shown to predict the cross-linguistic difference in the grammaticality effect. (shrink)

A measure of coherence is said to be reliability conducive if and only if a higher degree of coherence (as measured) among testimonies implies a higher probability that the witnesses are reliable. Recently, it has been proved that several coherence measures proposed in the literature are reliability conducive in scenarios of equivalent testimonies (Olsson and Schubert 2007; Schubert, to appear). My aim is to investigate which coherence measures turn out to be reliability conducive in the more general scenario where the (...) testimonies do not have to be equivalent. It is shown that four measures are reliability conducive in the present scenario, all of which are ordinally equivalent to the Shogenji measure. I take that to be an argument for the Shogenji measure being a fruitful explication of coherence. (shrink)

This systematic review identified and evaluated instruments measuring patients' perceptions of patient‐centred nursing care. Of 2629 studies reviewed, 12 were eligible for inclusion. Four instruments were reported: The Individualized Care Scale, the Client‐Centred Care Questionnaire, the Oncology patients' Perceptions of the Quality of Nursing Care Scale and the Smoliner scale. These instruments cover themes addressing patient participation and the clinician–patient relationship. Instruments were shown to have satisfactory psychometric properties, although not all were adequately assessed. More research is needed regarding test–retest (...) reliability, convergent and discriminant validity, validity with known groups and structural validity using confirmatory factor analysis. (shrink)

In this paper, I will present a puzzle for logical analyses, such as Russell’s analysis of definite descriptions and Recanati’s analysis of ‘that’-clauses. I will argue that together with Kripke’s disquotational principles connecting sincere assent and belief such non-trivial logical analyses lead to contradictions. Following this, I will compare the puzzle about logical analysis with Frege’s puzzle about belief ascriptions. We will see that although the two puzzles do have similarities, the solutions to Frege’s puzzle cannot be applied mutatis mutandis (...) to the puzzle about logical analysis. Hence, to say it with Kripke, the main thesis of this paper is that the puzzle is a puzzle. A complete solution to the puzzle promises a better understanding of both logical analyses and belief ascriptions. (shrink)

In 2018 more people than ever—70.8 million—were fleeing war, conflict, and persecution, according to a report from the UNHCR. This was the first time the figure exceeded 70 million. Internal refuge...

Environmental problems do have a universal dimension: they concern entire humanity as well as each human being individually, therefore, a new ecology needs to be developed in which man will play a principal role being a focal point of the study, its creator and executor of its assumptions, the discipline thus understood is one of the aspects of general ecology for it studies relationships between man as a species and its environment, the author believes that, regardless of the standpoint that (...) representatives of various sciences may take, the future of our species depends on the interdisciplinary approach toward the questions that are subject to human ecology studies. (shrink)

The starting point of the article is the thesis that Hippocrates’ rule: “the health of an ill person is the highest right” is not only the main rule of the conduct of medical staff but also includes a defined method of evaluation. According to the author, the consequence of such evaluation is a detailed rule “Firstly, not to harm”. This rule has got a universal character and cannot only be restricted to medical staff. Healthcare is not the domain of doctors (...) alone. It is everybody’s obligation, as it is to ensure that people don’t risk their own health or others’. In support of this approach, Władysław Tatarkiewicz’s considerations have been mentioned in the article, especially those that combine an individual sense of happiness with a state of health. In the end, the author refers to empirical research, which shows dependence on the state of health on and acquired lifestyle and points to the greater rationale of health prevention rather than institutional medical care. (shrink)

This article deals primarily with the examination of two key and exegetically demanding expressions in the text of the General Epistle of James, which relate to fundamental biblical principles on planning the future of the believer and reconciling human life with God’s will expressed in Holy Scripture. The first one is the hapax legomenon Ἄγε νῦν, the significance of which is closely related to updating of the affected principles with practice. The second term is ποιήσοµεν, which, in most translations, translates (...) as ‘remain’ and does not reflect the core idea of the examined verse. We prove that a more authentic and appropriate translation is ‘work’. Our aim was to find out what new interpretive possibilities the original biblical text offers. The constitutive starting point for research is Novum Testamentum Graecum – Editio Critica Maior. We then compared these texts with the Slovak Ecumenical Bible. The method of our exegetical work was not primarily comparison, but a linguistic analysis and historical-critical exegesis, the result of which is a completely new proposal for the translation of the scrutinised texts. Auxiliary materials were the most important patristic and exegetical commentaries. In conclusion, we state that the analysis made it possible to find a new translation of the researched text, which can really contribute to the improvement of further review and publication of the ecumenical translation of the Bible into various languages.Contribution: The article examines the source Greek biblical text of James 4:13–15 and reveals a new interpretation of it. This interpretation brings a new, biblical light into the field of planning, which is one of the most current topics nowadays. With its content and especially its conclusions, it contributes to the goals of this theological journal, the subject of which is also the research of Greek biblical manuscripts. (shrink)

Widespread consideration of the role of the public sector was bound to develop in a society confronted by a serious economic crisis.The reforms of local government carried out in the 60s and 70s have not led to the strengthening of local authorities and their means, as claimed deceptively in politica! speeches, hut towards more influence by central government on these authorities and ultimately to its increased power over the administration of society.There is not doubt that the state in its diligence (...) to run almost everything is not only failing in its task of governing hut is also putting society at risk. The administrations which come under the intermediary authorities could form a useful counterforce against the ever present invasion of the state.For reason of its reduced capabilities local government shows the first virtue of not being able to claim hegemony, but also of being an instrument close to the citizen and his control. Furthermore it could manage many tasks in the best way. (shrink)

An analysis of the epistemological structure of democratic deliberation as a procedure in which legal norms are constructed reveals that deliberation combines procedural and substantive aspects in a unique and inextricable manner. The co-original recognition of the private and public autonomy of all citizens provides the substantive critical standard against which the justice of norms is measured. At the same time, such recognition requires that the particular needs and values of all people concerned be taken into account. Given the privileged (...) epistemic access people have to their own particular perspective, this requirement implies the ineliminability of actual deliberative procedures. The open-ended nature of these constructive procedures is partly due to the fact that the rules of the procedure are counterfactual and themselves subject to interpretation. More importantly, it also reflects the historical nature of our human world and the freedom of moral persons to shape and reshape their preferences. (shrink)

A computational model of inference during story comprehension is presented, in which story situations are represented distributively as points in a high‐dimensional “situation‐state space.” This state space organizes itself on the basis of a constructed microworld description. From the same description, causal/temporal world knowledge is extracted. The distributed representation of story situations is more flexible than Golden and Rumelhart's [Discourse Proc 16 (1993) 203] localist representation.A story taking place in the microworld corresponds to a trajectory through situation‐state space. During the (...) inference process, world knowledge is applied to the story trajectory. This results in an adjusted trajectory, reflecting the inference of propositions that are likely to be the case. Although inferences do not result from a search for coherence, they do cause story coherence to increase. The results of simulations correspond to empirical data concerning inference, reading time, and depth of processing.An extension of the model for simulating story retention shows how coherence is preserved during retention without controlling the retention process. Simulation results correspond to empirical data concerning story recall and intrusion. (shrink)

This book offers a scientific whistleblower’s perspective on current implementation of federal research misconduct regulations. It provides a narrative of general interest that relates current cases of research ethics to philosophical, historical and sociological accounts of fraud in scientific research. The evidence presented suggests that the problems of falsification and fabrication remain as great as ever, but hidden because the current system puts universities in charge of investigations and permits them to use confidentiality regulations to hide the outcomes of investigations. (...) The book documents the significant conflict of interest that arises because federal regulation gives universities the responsibility to conduct investigations of their own faculty with severely limited oversight. The book is intended for young research scientists or anyone who wishes to understand the challenges faced by scientists in the workplace today. The central thread in the book is an exclusive account of an experienced research scientist who was the first to expose the facts that led to the longest running research misconduct investigation in the history of the National Science Foundation. (shrink)

In this paper, I examine the question of the scope of justice, in a not unusual distributive, egalitarian, and universalistic framework. Part I outlines some central features of the egalitarian theory of justice I am proposing. According to such a conception, justice is – at least prima facie – immediately universal, and therefore global. It does not morally recognize any judicial boundaries or limits. Part II examines whether, even from a universalistic perspective, there are moral or pragmatic grounds for rejecting (...) or limiting the global scope of justice. In particular, I scrutinize five universalistic objections: (1) the principle of “moral division of labor”; (2) the connection between cooperation and distributive justice; (3) the primacy of democracy; (4) the dangers of a world state; and (5) political‐pragmatic reasons. I intend to show that these objections cannot undermine the strong normative claims of global justice. At the most, political‐pragmatic reasons speak in favor of initially striving for somewhat less, in order to receive more general backing. (shrink)

There is no consensus as to whether a Liar sentence is meaningful or not. Still, a widespread conviction with respect to Liar sentences (and other ungrounded sentences) is that, whether or not they are meaningful, they are useless . The philosophical contribution of this paper is to put this conviction into question. Using the framework of assertoric semantics , which is a semantic valuation method for languages of self-referential truth that has been developed by the author, we show that certain (...) computational problems, called query structures , can be solved more efficiently by an agent who has self-referential resources (amongst which are Liar sentences) than by an agent who has only classical resources; we establish the computational power of self-referential truth . The paper concludes with some thoughts on the implications of the established result for deflationary accounts of truth. (shrink)

Drawing on the work of Robert Nozick and Johann Gottlieb Fichte, the author argues that human self-consciousness cannot be explained in naturalistic terms. Instead, it is a spontaneous phenomenon.

Die Fähigkeiten, nachzudenken und sich denkend auf Wirkliches zu beziehen, werden in der heutigen Philosophie des Geistes unter dem Begriff "Intentionalität" zusammengefasst. Wie können diese Fähigkeiten im Rahmen unseres naturwissenschaftlich geprägten Weltbildes erklärt werden? Stefan Kappner beantwortet diese Frage, indem er auf die Zeichentheorie von Charles Sanders Peirce zurückgreift.

According to Humean promotionalism about practical reasons, the fact that I have a reason to φ holds in virtue of the fact that φ-ing promotes one or more of my desires. The topic of this discussion note is the question of how best to understand the promotion relation. In particular, I defend a probabilistic understanding of promotion against a line of argument recently brought forth by Jeff Behrends, Joshua DiPaolo, and Nate Sharadin. Roughly, their argument is that probabilistic promotion leads (...) to implausible results in cases in which the relevant desires are certain to be satisfied. In these cases, a probabilistic understanding tells us that we do not have a reason to φ because the probability of desire satisfaction is 1 already. Contrary to Behrends', DiPaolo's, and Sharadin's claims, I argue that this is precisely the result a Humean theory of reasons should generate. According to Humeanism, we have reasons for actions because these actions make a difference to the occurrence of desire satisfaction - where the causal route to desire satisfaction is normatively irrelevant. Thus, if desire satisfaction is dead certain, we have no reason to do anything. (shrink)

Auxin is a simple molecule but one with a complex and crucial influence on plant development. Accumulation and response to this important plant hormone underlies events as diverse as embryo patterning and growth responses to light and gravity. As such, research on auxin can be traced back to Darwin and has flourished into an immense body of work that has often had implications beyond plant biology. The latest instalment of the auxin story is no different:(1) the solution of the crystal (...) structure of the auxin receptor TIR1 illustrates, in spectacular detail, precisely how auxin is perceived and provides an insight into the working of a new class of receptor, which seems likely to be the first example of a new paradigm in eukaryotic signal transduction. BioEssays 29:953–956, 2007. © 2007 Wiley Periodicals, Inc. (shrink)

Along with the Strait of Malacca and the Singapore Straits, the Strait of Hormuz is arguably the most important bottleneck in international navigation because a large part of the global oil production needs to be shipped through this passage, which is only a few kilometers wide. In the context of the dispute about Iran’s nuclear program and new sanctions, Iran has threatened to close the Strait of Hormuz for international shipping, effectively cutting off many Western countries from important oil imports. (...) In this article, the legality of such action as well as the legality of the mere threat to close the Strait of Hormuz are investigated. In addition to the International Law of the Sea, general rules of international law and the international law of armed conflict are taken into consideration. Particular emphasis is put on the sovereignty of other states, which is infringed upon by such threats on the part of the Iranian leadership. First, the question has to be answered whether a passage through these waters would be transit passage through a Strait or normal passage through the coastal state’s territorial sea. The authors of the article conclude that the regime of transit passage applies qua lex specialis, as far as the part of the Strait of Hormuz, which is included in Iran’s territorial waters, is concerned. The next step is to ask the question whether preventing such a passage as well as threatening to prevent such a passage are permissible for Iran. In this context, the potential abuse of otherwise permitted traffic separation schemes is highlighted. Traffic separation schemes are of particular importance in narrow but highly frequented bodies of water, such as the Strait of Hormuz. In addition, the contemporary Iranian state practice has received some attention. One issue to be considered in more detail is the requirement that foreign warships receive authorization from the coastal state prior to entry into the territorial sea. This approach might be incompatible with the right to innocent passage under both the Law of the Sea Convention and customary international law, as there is no clear legal source, which provides for this requirement. Finally, the authors look at the question of the legality of the mere threat to close the Strait of Hormuz as opposed to actually closing the Strait. The sovereignty of other states may be affected to such an extent that such threats already amount to a violation of international law. In light of the historic precedents during the Iran-Iraq War, these threats should not be dismissed lightly. Iran would be well advised to refrain from such rhetoric. (shrink)

En el presente trabajo me ocupo del pensamiento latinoaméricano y su relación con la cultura europea y occidental, en particular me concetro en la teoría (post) colonial. El primer paso es conectar conocimiento y localización para presentar la relación asimétrica de poder entre europa y latinoamérica, tal como fue establecida en el periodo colonial despues de 1492. Esta discusión nos lleva a pensadores como Anibal Quijano, Enrique Dussel y Walter Mignolo, quienes conciben la colonialidad como el discurso de poder y (...) conocimiento que domina la relación entre centro y periferia. En tanto que la colonialidad establece un dualismo entre una posición hegemónica y una subalterna. Los pensadores latinoamericanos usan esta supuesta posición subalterna, tanto para criticar el discurso de la modernidad occidental, como también para clarificar su identidad desde la perspectiva de la liberación. Esto lo hacen desde la perspectiva de la opresión política, económica y epistémica. Aquí se conecta la crítica del discurso colonial del pensamiento latiniamericano con los estudios post-coloniales, donde la pretensión de liberación cultural y material en sentido práctico es la pretención que los divide. (shrink)