Recent experimental evidence suggests that most of the genome is transcribed into non‐coding RNAs. The initial transcripts undergo further processing generating shorter, metabolically stable RNAs with diverse functions. Small nucleolar RNAs (snoRNAs) are non‐coding RNAs that modify rRNAs, tRNAs, and snRNAs that were considered stable. We review evidence that snoRNAs undergo further processing. High‐throughput sequencing and RNase protection experiments showed widespread expression of snoRNA fragments, known as snoRNA‐derived RNAs (sdRNAs). Some sdRNAs resemble miRNAs, these can associate with argonaute proteins and (...) influence translation. Other sdRNAs are longer, form complexes with hnRNPs and influence gene expression. C/D box snoRNA fragmentation patterns are conserved across multiple cell types, suggesting a processing event, rather than degradation. The loss of expression from genetic loci that generate canonical snoRNAs and processed snoRNAs results in diseases, such as Prader‐Willi Syndrome, indicating possible physiological roles for processed snoRNAs. We propose that processed snoRNAs acquire new roles in gene expression and represent a new class of regulatory RNAs distinct from canonical snoRNAs.Also watch the Video Abstract. (shrink)

The aim of this book is to present and analyze philosophical conceptions concerning mathematics and logic as formulated by Polish logicians, mathematicians and philosophers in the 1920s and 1930s. It was a remarkable period in the history of Polish science, in particular in the history of Polish logic and mathematics. Therefore, it is justified to ask whether and to what extent the development of logic and mathematics was accompanied by a philosophical reflection. We try to answer those questions by analyzing (...) both works of Polish logicians and mathematicians who have a philosophical temperament as well as their research practice. Works and philosophical views of the following Polish scientists will be analyzed: Wacław Sierpiński, Zygmunt Janiszewski, Stefan Mazurkiewicz, Stefan Banach Hugo Steinhaus, Eustachy Żylińsk and Leon Chwistek, Jan Łukasiewicz, Zygmunt Zawirski, Stanisław Leśniewski, Tadeusz Kotarbiński, Kazimierz Ajdukiewicz, Alfred Tarski, Andrzej Mostowski and Henryk Mehlberg, Jan Sleszyński, Stanisław Zaremba and Witold Wilkosz. To indicate the background of scientists being active in the 1920s and 1930s we consider in Chapter 1 some predecessors, in particular: Jan Śniadecki, Józef Maria Hoene-Wroński, Samuel Dickstein and Edward Stamm. (shrink)

Process reliabilist accounts claim that a belief is justified when it is the result of a reliable belief-forming process. Yet over what range of possible token processes is this reliability calculated? I argue against the idea that _all_ possible token processes (in the actual world, or some other subset of possible worlds) are to be considered using the case of a user acquiring beliefs based on the output of an AI system, which is typically reliable for a substantial local range (...) but unreliable when all possible inputs are considered. I show that existing solutions to the generality problem imply that these cases cannot be solved by a more fine-grained typing of the belief-forming process. Instead, I suggest that reliability is evaluated over a range restricted by the content of the actual belief and by the similarity of the input to the actual input. (shrink)

Towards a critical posthumanism -- Genealogy of posthumanism -- Our posthuman humanity and the multiplicity of its forms -- Posthumanism and science fiction -- Interdisciplinarity and the posthumanities -- Posthumanism, digitalization, and new media -- Posthumanity, subject, and system -- Other side of life.

This volume features a collection of essays on consciousness, which has become one of the hot topics at the crossroads between neuroscience, philosophy, and religious studies. Is consciousness something the brain produces? How can we study it? Is there just one type of consciousness or are there different states that can be discriminated? Are so called "higher states of consciousness" that some people report during meditation pointing towards a new understanding of consciousness? Meditation research is a new discipline that shows (...) new inroads into the study of consciousness. If a meditative practice changes brain structure itself this is direct proof of the causal influence of consciousness onto its substrate. If different states of consciousness can be linked with properties and states of the brain this can be used to study consciousness more directly. If the sense of self is modifiable through meditative techniques and this can be objectively shown through neuro-imaging, this has profound implications for our understanding of who we are. Can consciousness, in deep states of meditative absorption, actually access some aspect of reality which we normally don't? Meditation research can potentially foster us with a new access to the phenomenological method in general. This has even been branded with a new catch-phrase: Contemplative Science. It brings together the most modern neuroscientific approach and the most advanced phenomenological methodology of studying the mind from within, through highly skilled self-observation that has gone through many thousand hours of honing the capacity to look carefully, without distraction. This book addresses these issues by bringing together some of the leading researchers and thinkers in the field. The scope of the volume reaches from first person neuroscience to Indian philosophy, from pedagogic applications to epistemological aspects and from compassion meditation to the study of brain activity. (shrink)

This paper establishes a theoretical linkage between Antonio Gramsci and Frantz Fanon. Gramsci’s critical-historicist method and its relationship to humanism, his integral understanding of Marxism, and emphasis on the moment of political practice resonate with Fanon’s articulation of the subjective and political-economic aspects of the colonial question, his activistic materialism, and his dialectically humanist universalism forged through anti-colonial struggle. Establishing this linkage presupposes engaging distinct currents of postcolonial Gramscianism in relation to each other and to the philological turn in Gramsci (...) scholarship. In turn, a Gramsci–Fanon convergence helps elucidate the specificities of (post-)colonial contexts without elevating these into a civilisational-ontological difference. Emphasising their geographical sensitivity as a meeting point, pushing Gramsci towards Fanon helps us treat the global South and imperial heartlands relationally, in historico-geographical and specifically political terms. A Fanonian Gramsci (or Gramscian Fanon) thus allows us to tackle Eurocentrism without closing doors to a counter- or postcolonial Marxism. (shrink)

An English double-embedded relative clause from which the middle verb is omitted can often be processed more easily than its grammatical counterpart, a phenomenon known as the grammaticality illusion. This effect has been found to be reversed in German, suggesting that the illusion is language specific rather than a consequence of universal working memory constraints. We present results from three self-paced reading experiments which show that Dutch native speakers also do not show the grammaticality illusion in Dutch, whereas both German (...) and Dutch native speakers do show the illusion when reading English sentences. These findings provide evidence against working memory constraints as an explanation for the observed effect in English. We propose an alternative account based on the statistical patterns of the languages involved. In support of this alternative, a single recurrent neural network model that is trained on both Dutch and English sentences is shown to predict the cross-linguistic difference in the grammaticality effect. (shrink)

The globalization movement in recent decades has meant rapid growth in trade, financial transactions, and cross-country ownership of economic assets. In this article, we examine how the globalization of national business systems has influenced the framing of corporate social responsibility (CSR). This is done using text analysis of CEO letters appearing in the annual reports of 15 major corporations in Sweden during a period of transformational change. The results show that the discourse about CSR in the annual reports has changed (...) from a national and communitarian view of social responsibility (cf. a negotiated view of CSR) toward an international and individualistic view of social responsibility (cf. a self-regulating view of CSR). The article contributes theoretically (1) by adding a national–global dimension to previous conceptualizations of CSR and (2) by showing that the rise of CSR discourse and activities in the last 10 years does not have to imply an increased commitment and interest in corporate responsibility per se, only that there are increased societal expectations that corporations should develop the capability to act more independently as moral agents. (shrink)

I am focusing here on the main counterarguments that were raised against a thesis I put forward in my article “Nietzsche, the Overhuman, and Transhumanism” (2009), namely that significant similarities can be found on a fundamental level between the concept of the posthuman, as put forward by some transhumanists, and Nietzsche’s concept of the overhuman. The articles with the counterarguments were published in the recent “Nietzsche and European Posthumanisms” issue of The Journal of Evolution and Technology (January-July 2010). As several (...) commentators referred to identical issues, I decided that it would be appropriate not to respond to each of the articles individually, but to focus on the central arguments and to deal with the counterarguments mentioned in the various replies. I am concerned with each topic in a separate section. The sections are entitled as follows: 1. Technology and evolution; 2. Overcoming nihilism; 3. Politics and liberalism; 4. Utilitarianism or virtue ethics?; 5. The good Life; 6. Creativity and the will to power; 7. Immortality and longevity; 8. Logocentrism; 9. The Third Reich. When dealing with the various topics, I am not merely responding to counterarguments; I also raise questions concerning transhumanism and put forward my own views concerning some of the questions I am dealing with. (shrink)

A computational model of inference during story comprehension is presented, in which story situations are represented distributively as points in a high‐dimensional “situation‐state space.” This state space organizes itself on the basis of a constructed microworld description. From the same description, causal/temporal world knowledge is extracted. The distributed representation of story situations is more flexible than Golden and Rumelhart's [Discourse Proc 16 (1993) 203] localist representation.A story taking place in the microworld corresponds to a trajectory through situation‐state space. During the (...) inference process, world knowledge is applied to the story trajectory. This results in an adjusted trajectory, reflecting the inference of propositions that are likely to be the case. Although inferences do not result from a search for coherence, they do cause story coherence to increase. The results of simulations correspond to empirical data concerning inference, reading time, and depth of processing.An extension of the model for simulating story retention shows how coherence is preserved during retention without controlling the retention process. Simulation results correspond to empirical data concerning story recall and intrusion. (shrink)

This systematic review identified and evaluated instruments measuring patients' perceptions of patient‐centred nursing care. Of 2629 studies reviewed, 12 were eligible for inclusion. Four instruments were reported: The Individualized Care Scale, the Client‐Centred Care Questionnaire, the Oncology patients' Perceptions of the Quality of Nursing Care Scale and the Smoliner scale. These instruments cover themes addressing patient participation and the clinician–patient relationship. Instruments were shown to have satisfactory psychometric properties, although not all were adequately assessed. More research is needed regarding test–retest (...) reliability, convergent and discriminant validity, validity with known groups and structural validity using confirmatory factor analysis. (shrink)

Topic of the paper is Q-logic – a logic of agency in its temporal and modal context. Q-logic may be considered as a basal logic of agency since the most important stit-operators discussed in the literature can be defined or axiomatized easily within its semantical and syntactical framework. Its basic agent dependent operator, the Q-operator (also known as Δ- or cstit-operator), which has been discussed independently by F. v. Kutschera and B. F. Chellas, is investigated here in respect of its (...) relation to other temporal and modal operators. The main result of the paper, then, is a completeness result for a calculus of Q-logic with respect to a semantics defined on the tree-approach to agency as introduced and developed by, among others, F. v. Kutschera and N. D. Belnap. (shrink)

This book offers a scientific whistleblower’s perspective on current implementation of federal research misconduct regulations. It provides a narrative of general interest that relates current cases of research ethics to philosophical, historical and sociological accounts of fraud in scientific research. The evidence presented suggests that the problems of falsification and fabrication remain as great as ever, but hidden because the current system puts universities in charge of investigations and permits them to use confidentiality regulations to hide the outcomes of investigations. (...) The book documents the significant conflict of interest that arises because federal regulation gives universities the responsibility to conduct investigations of their own faculty with severely limited oversight. The book is intended for young research scientists or anyone who wishes to understand the challenges faced by scientists in the workplace today. The central thread in the book is an exclusive account of an experienced research scientist who was the first to expose the facts that led to the longest running research misconduct investigation in the history of the National Science Foundation. (shrink)

Is there any good reason to believe in Nietzsche's metaphysics even thought he himself claims that it is not "the truth" in correspondence with the world? According to Danto, Nietzsche's metaphysics is only valid for Nietzsche himself. However, this answer does not take into consideration Nietzsche's claim for the general superiority of his philosophy. Nietzsche's view seems inconsistent: on the one hand, he claimed all perspectives are equally false in respect to "the truth," but on the other, he regarded his (...) view as superior. This book explains in which respect Nietzshe justifies his claims, that Nietzsche's position is not inconsistent, and why consistency is important for him. (shrink)

The number of people with dementia is increasing worldwide. At the same time, family and professional caregivers’ resources are limited. A promising approach to relieve these carers’ burden and assist people with dementia is assistive technology. In order to be useful and accepted, such technologies need to respect the values and needs of their intended users. We applied the value sensitive design approach to identify values and needs of patients with dementia and family and professional caregivers in respect to assistive (...) technologies to assist people with dementia in institutionalized care. Based on semi-structured interviews of residents/patients with cognitive impairment, relatives, and healthcare professionals (10 each), we identified 44 values summarized by 18 core values. From these values, we created a values’ network to demonstrate the interplay between the values. The core of this network was caring and empathy as most strongly interacting value. Furthermore, we found 36 needs for assistance belonging to the four action fields of activity, care, management/administration, and nursing. Based on these values and needs for assistance, we created possible use cases for assistive technologies in each of the identified four action fields. All these use cases already are technologically feasible today but are not currently being used in healthcare facilities. This underlines the need for development of value-based technologies to ensure not only technological feasibility but also acceptance and implementation of assistive technologies. Our results help balance conflicting values and provide concrete suggestions for how engineers and designers can incorporate values into assistive technologies. (shrink)

This is an English translation of Swieżawski’s original article titled “Początki nowożytnego arystotelizmu chrześcijańskiego,” published in Roczniki Filozoficzne 19 (1971): 41–56. The paper focuses on four main topics: (a) increased theological standing of Aristotle in the 15th century; (b) critical concerns over the compatibility of Aristotle’s philosophy with Christianity, as well as over its interpretation by Averroes; (c) search for the “historical Aristotle” and an objective assessment of the resultant interpretations of Aristotle’s philosophy; (d) identification of Thomism with Christian Aristotelianism.

La 4e de couverture indique : "La pensée de Chaïm Perelman a profondément marqué la théorie du droit du xxe siècle. S'opposant au positivisme juridique, c'est-à-dire aux théories qui réduisent le droit à la loi, l'essentiel de son apport réside dans une théorie de l'argumentation qui rebat les cartes de la logique juridique, en mettant l'accent sur la manière de raisonner, et plus profondément de discuter. La vérité n'est plus chez Perelman une notion centrale. Elle est remplacée par l'idée d'adhésion, (...) qui permet de rendre compte du caractère progressif de l'assentiment. Loin d'une description désincarnée et décontextualisée, Perelman intègre une série de paramètres : qui parle, à qui, où, quand, dans quelle situation. Les arguments ne sont ainsi jamais totalement contraignants : c'est toujours le contexte qui conditionne leur acceptabilité. Un procédé comme la présomption d'innocence peut être compris, non comme une valeur fondamentale, mais comme un simple outil destiné à compenser l'absence de connaissance. Le droit apparaît ainsi comme un art de gérer les controverses. Cette vision s'inscrit dans une « philosophie du raisonnable » où la valeur d'une idée se mesure à sa capacité d'emporter l'accord des participants à la controverse qui naît de son introduction. Le domaine de l'argumentation est « celui du vraisemblable, du plausible, du probable, dans la mesure où ce dernier échappe aux certitudes du calcul". (shrink)

Musikalische Werke sind keine Personen. Dennoch sagen wir zum Beispiel, ein Werk sei melancholisch, drucke Freude aus oder verbreite eine zuversichtliche Stimmung. Doch mit welchem Recht? Die Beantwortung dieser Frage ist grundlegend fur die Musikphilosophie. In der Monographie wird systematisch das Wesen und, auf den Resultaten dieses ersten Teils aufbauend, im zweiten Teil der Wert der Expressivitat von Musik untersucht. Dabei wird ein historisch und empirisch informierter, integrativer Ansatz musikalischer Expressivitat ausgearbeitet. Die Untersuchung tragt so zu einem besseren Verstandnis des (...) Mediums Musik und seiner Bedeutung fur das menschliche Dasein bei. (shrink)

Two Sides of the Same Coin. Unpacking Rainer Forst’s Basic Right to Justification This paper makes two comments on Rainer Forst’s keynote contribution. It argues, first, that three important distinctions introduced by Forst are, in fact, all different versions of the more primary distinction between the a priori reconstruction of basic rights by philosophers and the discursive construction of basic rights by citizens. It proposes, secondly, an alternative discourse-theoretical reconstruction which makes a distinction between the basic right to justification and (...) the basic right to choose your own ends as two different but inseparable rights – two sides of the same coin – which jointly provide the moral ground for our basic rights as citizens. (shrink)

Drawing on the work of Robert Nozick and Johann Gottlieb Fichte, the author argues that human self-consciousness cannot be explained in naturalistic terms. Instead, it is a spontaneous phenomenon.

Die Fähigkeiten, nachzudenken und sich denkend auf Wirkliches zu beziehen, werden in der heutigen Philosophie des Geistes unter dem Begriff "Intentionalität" zusammengefasst. Wie können diese Fähigkeiten im Rahmen unseres naturwissenschaftlich geprägten Weltbildes erklärt werden? Stefan Kappner beantwortet diese Frage, indem er auf die Zeichentheorie von Charles Sanders Peirce zurückgreift.

This is the first volume of essays on Berkeley's Three Dialogues, a classic of early modern philosophy. Leading experts cover all the central issues in the text: the rejection of material substance, the nature of perception and reality, the limits of human knowledge, and the perceived threats of skepticism, atheism, and immorality.

According to Humean promotionalism about practical reasons, the fact that I have a reason to φ holds in virtue of the fact that φ-ing promotes one or more of my desires. The topic of this discussion note is the question of how best to understand the promotion relation. In particular, I defend a probabilistic understanding of promotion against a line of argument recently brought forth by Jeff Behrends, Joshua DiPaolo, and Nate Sharadin. Roughly, their argument is that probabilistic promotion leads (...) to implausible results in cases in which the relevant desires are certain to be satisfied. In these cases, a probabilistic understanding tells us that we do not have a reason to φ because the probability of desire satisfaction is 1 already. Contrary to Behrends', DiPaolo's, and Sharadin's claims, I argue that this is precisely the result a Humean theory of reasons should generate. According to Humeanism, we have reasons for actions because these actions make a difference to the occurrence of desire satisfaction - where the causal route to desire satisfaction is normatively irrelevant. Thus, if desire satisfaction is dead certain, we have no reason to do anything. (shrink)

Adventure -- Call -- Brother paul -- Transgression -- Two loves -- Freedom -- Interlude -- Freedom again -- Between Heidegger and Derrida -- Dancing in the void -- The advent of weak theology -- Kingdom.

In this article I attempt to find out the appropriate understanding of “liberal education”. Firstly, I distinguish the two most important meanings of the notion “freedom” which I call momentary and lifelong freedom. Momentary freedom is a type of negative freedom, and lifelong freedom a type of positive freedom. Secondly, I show the consequences, which these two meanings of “freedom” have on the practice of a “liberal education”. Finally, I analyse which type of liberal education is the best.

Auxin is a simple molecule but one with a complex and crucial influence on plant development. Accumulation and response to this important plant hormone underlies events as diverse as embryo patterning and growth responses to light and gravity. As such, research on auxin can be traced back to Darwin and has flourished into an immense body of work that has often had implications beyond plant biology. The latest instalment of the auxin story is no different:(1) the solution of the crystal (...) structure of the auxin receptor TIR1 illustrates, in spectacular detail, precisely how auxin is perceived and provides an insight into the working of a new class of receptor, which seems likely to be the first example of a new paradigm in eukaryotic signal transduction. BioEssays 29:953–956, 2007. © 2007 Wiley Periodicals, Inc. (shrink)