Mammalian mitochondrial DNA (mtDNA) replication and repair have been studied intensively for the last 50 years. Although recently advances in elucidating the molecular mechanisms of mtDNA maintenance and the proteins involved in these have been made, there are disturbing gaps between the existing theoretical models and experimental observations. Conflicting data and hypotheses exist about the role of RNA and ribonucleotides in mtDNA replication, but also about the priming of replication and the formation of pathological rearrangements. In the presented review, we (...) have attempted to match these loose ends and draft consensus where it can be found, while identifying outstanding issues for future research. (shrink)

In this paper, we show that Arrow’s well-known impossibility theorem is instrumental in bringing the ongoing discussion about verisimilitude to a more general level of abstraction. After some preparatory technical steps, we show that Arrow’s requirements for voting procedures in social choice are also natural desiderata for a general verisimilitude definition that places content and likeness considerations on the same footing. Our main result states that no qualitative unifying procedure of a functional form can simultaneously satisfy the requirements of Unanimity, (...) Independence of irrelevant alternatives and Non-dictatorship at the level of sentence variables. By giving a formal account of the incompatibility of the considerations of content and likeness, our impossibility result makes it possible to systematize the discussion about verisimilitude, and to understand it in more general terms. (shrink)

In this article, we develop an approach for the moral assessment of research and development networks on the basis of the reflective equilibrium approach proposed by Rawls and Daniels. The reflective equilibrium approach aims at coherence between moral judgments, principles, and background theories. We use this approach because it takes seriously the moral judgments of the actors involved in R & D, whereas it also leaves room for critical reflection about these judgments. It is shown that two norms, namely reflective (...) learning and openness and inclusiveness, which are used in the literature on policy and technological networks, contribute to achieving a justified overlapping consensus. We apply the approach to a case study about the development of an innovative sewage treatment technology and show how in this case the two norms are or could be instrumental in achieving a justified overlapping consensus on relevant moral issues. (shrink)

Bible and tradition remain silent on intelligent extraterrestrial life, and few modern theologians have expressed themselves on this topic. Scientific insight suggests the possibility, even likelihood, of the development of life on extrasolar earthlike planets. It is argued that such life forms would resemble earthly life and also develop a religious and moral life. As creatures with free will they would be prone to sin and in need of salvation. It is argued that this would not require multiple incarnations, since (...) Jesus is the cosmic Christ. (shrink)

Business Ethics: A European Review, EarlyView.

In this paper we report on our experiences with using network analysis to discern and analyse ethical issues in research into, and the development of, a new wastewater treatment technology. Using network analysis, we preliminarily interpreted some of our observations in a Group Decision Room session where we invited important stakeholders to think about the risks of this new technology. We show how a network approach is useful for understanding the observations, and suggests some relevant ethical issues. We argue that (...) a network approach is also useful for ethical analysis of issues in other fields of research and development. The abandoning of the overarching rationality assumption, which is central to network approaches, does not have to lead to ethical relativism. (shrink)

Sjoerd Griffioen investigates the polemics between Löwith, Blumenberg and Schmitt in the German secularization debate (1950’s-1980’s). ‘Secularization’ is revealed as a contested concept in ideological struggles over modernity and religion, both in this debate and contemporary postsecularism.

The subject of the present inquiry is the approach-to-the-truth research, which started with the publication of Sir Karl Popper's Conjectures and Refutations. In the decade before this publication, Popper fiercely attacked the ideas of Rudolf Carnap about confirmation and induction; and ten years later, in the famous tenth chapter of Conjectures he introduced his own ideas about scientific progress and verisimilitude. Abhorring inductivism for its apprecia tion of logical weakness rather than strength, Popper tried to show that fallibilism could serve (...) the purpose of approach to the truth. To substantiate this idea he formalized the common sense intuition about preferences, that is: B is to be preferred to A if B has more advantages andfewer drawbacks than A. In 1974, however, David Millerand Pavel Tichy proved that Popper's formal explication could not be used to compare false theories. Subsequently, many researchers proposed alternatives or tried to improve Popper's original definition. (shrink)

In the 1980s, philosophical, historical and social studies of science underwent a change which later evolved into a turn to practice. Analysts of science were asked to pay attention to scientific practices in meticulous detail and along multiple dimensions, including the material, social and psychological. Following this turn, the interest in scientific practices continued to increase and had an indelible influence in the various fields of science studies. No doubt, the practice turn changed our conceptions and approaches of science, but (...) what did it really teach us? What does it mean to study scientific practices? What are the general lessons, implications, and new challenges? This volume explores questions about the practice turn using both case studies and theoretical analysis. The case studies examine empirical and mathematical sciences, including the engineering sciences. The volume promotes interactions between acknowledged experts from different, often thought of as conflicting, orientations. It presents contributions in conjunction with critical commentaries that put the theses and assumptions of the former in perspective. Overall, the book offers a unique and diverse range of perspectives on the meanings, methods, lessons, and challenges associated with the practice turn. (shrink)

Abstract.The title question was raised by Philip Hefner in an editorial in the March 2007 issue of Zygon, and answered in various ways in sixteen guest editorials in the June, September, and December 2007 issues. In this article, after defining some pertinent concepts, I comment on these essays. I review critical statements made by the guest editorialists and survey their proposals for further dialogue topics. I conclude with my own views on the future of the dialogue and the role of (...) Zygon therein. (shrink)

Epidemiological studies have shown that environmental green space contributes to the reduction of psychosis incidence in the population. Clarifying the psychological and neuro-functional mechanisms underlying the risk-decreasing effects of green surroundings could help optimize preventive environmental interventions. This perspective article specifically aims to open a new window on the link between environmental green space and psychosis by considering its core psychopathological features. Psychotic disorders, such as schizophrenia, are essentially characterized by self-disturbances. The psychological structure of the self has been described (...) as a multidimensional phenomenon that emerges from the reciprocal interaction with the environment through intrinsic and extrinsic self-processes. The intrinsic self refers to the experience of mental activity and environmental information as inherently related to one’s own person, which involves self-referential processing, self-reflection, memory, interoception, and emotional evaluation. The extrinsic self refers to sensorimotor interactions with the environment and the sense of agency, that is, the experience of being the source of one’s own actions and the multisensory consequences thereof. In psychosis, anomalous self-processing has been related to a functional fragmentation of intrinsic and extrinsic self-processes and related brain networks. Moreover, evidence from cognitive neuroscience suggests that green space could have beneficial effects on self-related processing. Based on the literature, it could be hypothesized that self-processing is involved in mediating the beneficial effects of green space for psychosis. Considering the multidimensionality of the self, it is proposed that urban green space design aimed at improving mental health ideally impacts the complexity of self-facets and thus restores the individual’s self. (shrink)

This is a response to the article published by Silvia Fazzo, ‘A Hypothetical Premise about Eternal Cosmic Motion in Physics VIII 1.250b13’ in a previous issue of Aristotelica, in which she argues on the basis of the sources, Vind. Phil. gr. 100 in particular, that at Physica VIII 1.250b13 one should adopt the hypothetical reading ἀλλ’ εἰ ἦν, καὶ ἀεὶ ἔσται, rather than the categorical reading ἀλλ’ ἀεὶ ἦν καὶ ἀεὶ ἔσται. We argue that a complete and methodologically sound consideration (...) of all the textual evidence available shows that the proposal is implausible. (shrink)

Comparison of the concepts of creation from chaos and creation out of nothing (creatio ex nihilo) leads me to reject the latter for several reasons: it is not the biblical concept, and it presents serious conceptual, scientific, and theological problems. Chaos theology is outlined under the headings creation from chaos; chaos and contingency; chaos, evil, and creativity; chaos and incarnation; chaos and eschatology. It is shown to be well suited for the science‐theology dialogue by some examples of its application to (...) aspects of cosmic and biological evolution: initial mystery, separation and ordering; chaos and entropy; contingency and fine‐tuning of the universe; purpose and progressiveness in evolution; and complexity theory and chaos events. (shrink)

The notion of template has recently been discussed in relation to cross-disciplinary transfer of modeling efforts and in relation to the representational content of models. We further develop and disambiguate the notion of template and find that, suitably developed, it is useful in distinguishing and analyzing different types of transfer, none of which supports a non-representationalist view of models. We illustrate our main findings with the modeling of technology substitution with Lotka-Volterra Competition equations.

In his lectures from 1987, Deleuze draws an analogy between Michelangelo's figures and Leibnizian substances by claiming that neither are essences but rather sources of modifications or manners of being. The best way to explore this analogy, I argue, is by focusing on Michelangelo's preference for serpentine shapes. By putting key passages from The Logic of Sensation, The Fold: Leibniz and the Baroque and What is Philosophy? in resonance with the Leibnizian accounts of corporeal aggregates and possible worlds on the (...) one hand and art history on the other, I will try to develop a Deleuzian concept for the typically Mannerist ideal of the serpentine figure. Although Deleuze usually prefers to speak in musical terms of refrains and counterpoints by which various blocs of sensation resonate with each other, in the visual arts it is the serpentine figure that renders visible sensory becoming as a rhythmic counter-positioning of possible worlds within a single body without organs. (shrink)

In Metaphysics M.2, 1077a9-14, Aristotle appears to argue against the existence of Platonic Forms on the basis of there being certain universal mathematical proofs which are about things that are ‘beyond’ the ordinary objects of mathematics and that cannot be identified with any of these. It is a very effective argument against Platonism, because it provides a counter-example to the core Platonic idea that there are Forms in order to serve as the object of scientific knowledge: the universal of which (...) theorems of universal mathematics are proven in Greek mathematics is neither Quantity in general nor any of the specific quantities, but Quantity-of-type-x. This universal cannot be a Platonic Form, for it is dependent on the types of quantity over which the variable ranges. Since for both Plato and Aristotle the object of scientific knowledge is that F which explains why G holds, as shown in a ‘direct’ proof about an arbitrary F (they merely disagree about the ontological status of this arbitrary F, whether a Form or a particular used in so far as it is F), Plato cannot maintain that Forms must be there as objects of scientific knowledge - unless the mathematics is changed. (shrink)

Aristotle's philosophically most explicit and sophisticated account of the concept of a (primary-)universal proof is found, not in "Analytica Posteriora" 1.4, where he introduces the notion, but in 1.5. In 1.4 Aristotle merely says that a universal proof must be of something arbitrary as well as of something primary and seems to explain primacy in extensional terms, as concerning the largest possible domain. In 1.5 Aristotle improves upon this account after considering three ways in which we may delude ourselves into (...) thinking we have a primary-universal proof. These three sources of delusion are shown to concern situations in which our arguments do establish the desired conclusion for the largest possible domain, but still fail to be real primary-universal proofs. Presupposing the concept of what may be called an immediate proof, in which something is proved of an arbitrary individual, Aristotle in response now demands that a proof be immediate of the primary thing itself and goes on to sketch a framework in which an intensional criterion for primacy can be formulated. For the most part this article is a comprehensive and detailed commentary on Aristotle's very concise exposition in 1.5. One important result is that the famous passage 74a17-25 referring to two ways of proving the alternation of proportions cannot be used as evidence for the development of pre-Euclidean mathematics. (shrink)

In recent years the humanities, social sciences and neuroscience have witnessed an 'affective turn, ' especially in discourses around post-Fordist labor, economic and ecological crises, populism and identity politics, mental health, and political struggle. This new awareness would be unthinkable without the pioneering work of Gilles Deleuze, who replaced judgment with affect as the very material movement of thought: every concept is an affective experience, a becoming. Besides entirely active affects, the highest practice of thought, there is no thought without (...) passive affects or passions. Instead of a calm and rational philosophy of passions, Deleuzian thought is therefore inseparable from "isolated and passionate cries" that deny what everybody knows and what nobody can deny: "every true thought is an aggression." This inseparability of reason and passion is by no means an anti-intellectualist or irrationalist stance. Rather, it is critical, since it protects reason from its self-imposed stupidity (betise) by relating it to the unthought forces that condition it. And it is clinical, because thought becomes possessed by a power of selection. The purely active, i.e. free-floating, unrecorded desire, is never enough to produce a consistent relation to the future, which is why we need the passions to give us an initial orientation, to force and enable us to think. Passions are the beliefs, perceptions, representations, and opinions that attach us to the world; they make up the very material of which our lives and thoughts are composed. Instead of truth as the ultimate criterion of judgment, the only principle according to which affective becomings can be selected and evaluated is the extent to which they proliferate joy. Spinoza and Marx show how the recruitment of desire traditionally takes place through the tyrants and priests who inspire sad passions in us. Similarly, the work of Deleuze and Guattari on capitalism and schizophrenia can be read as an encyclopedia of the passions that constitute the affective infrastructure of the socius of contemporary capitalism. If it takes a lot of inventiveness or imagination to be able to diagnose our present becomings, this is because becomings are always composites of joyful and sad passions. Capitalism could not exist if it did not also inspire happiness, love, courage, and perhaps even beatitude. That is why, today, we witness "the spectacle of the happily dominated" (Frederic Lordon) of the self-entrepreneur, the managerial class, the flex worker, the citizen-consumer, the bean-roasting hipster, and the self-managed team. It is within this field of contradictory and heterogeneous passions that the authors of this volume pursue the diagnosis of our past and present becomings. Their contributions add up to a systematic taxonomy of the passions and indicate their importance for a thinking that reaches beyond itself. (shrink)

Introduction Harry Collins is internationally recognized as a distinguished sociologist of science who writes creatively on a substantial number of varied subjects. He is acknowledged as one of the prominent specialists on the topic of tacit knowledge and has played an important role in the introduction of this topic into science studies. He has investigated the topic extensively, most famously through several case studies of physics [Collins 1974, 1984, 1985, 1990, 2001a,b, 2004], [Collins &...

How do, according to Aristotle, peirastic arguments, which are employed by nonscientists to put professed scientists to the test, work, and how do they differ from genuine scientific arguments? A peirastic argument succeeds in unmasking a would-be scientist if it establishes an inconsistency among the answers given. These answers may only comprise: propositions which are proper to the field and which everybody can know; propositions which only scientists may know; “common” propositions that everybody, including various sciences, uses in all kind (...) of arguments. On the other hand, a peirastic argument fails to do its job if it either features or presupposes in addition propositions which would justify a fallacy, or if it purports to be scientific. The latter type of bad peirastic argument crucially depend on common propositions where scientific arguments explain by reference to combinations of the primitive items of the science in question. (shrink)

In this paper, we discuss and extend the taxonomy of tacit knowledge proposed by Collins in his 2010 book, Tacit and Explicit Knowledge. First, we question the definition and the name of one of Collins’s three categories of TK, namely Relational Tacit Knowledge (RTK). After having explained the true fundamental principle that individuates RTK as one category distinct from the two others (Somatic Tacit Knowledge STK and Collective Tacit Knowledge CTK), we suggest an alternative name for RTK, which fits this (...) principle better. Second, our analyses identify a possible ambiguity in the interpretation of RTK, STK and CTK, and indicate how to avoid the related possible confusions. For this purpose, we introduce several notations that specify Collins’s ones. The corresponding developments strengthen and specify a point implicitly suggested in Collins’s book, namely the existence of a serious asymmetry between RTK on the one hand, and STK/CTK on the other. Third, the paper attempts to elaborate and complete Collins’s framework. In this vein, we introduce the possibility of different sub-types of RTK. One of these sub-cases raises the issue of individual, intellectual tacit knowledge—a case that does not seem to have any place in Collins’s picture. We also look at Collins’s framework in a dynamical perspective, and discuss the possibility—not considered by Collins—of dynamic transformations between some of the three categories. Finally, we make two suggestions in order to avoid confusions or misunderstandings when using Collins’s distinctions. When the qualities “explicit”, “explicable” or “tacit” are attributed to some knowledge, these qualities should always be accompanied by the specification for whom and when. Moreover, the attributions “explicit” and “explicable” should always indicate which of Collins’s four senses is meant—elaboration, transformation, mechanization or scientific explanation. (shrink)

Examining afresh the 16th-century style of mannerism, Sjoerd van Tuinen synthesises philosophy and aesthetics to demonstrate not only the contemporary relevance of mannerism but its broader significance as a form of modal thinking. Beyond a style of art that spurned the balance and proportion of earlier Renaissance painting in favour of compositional instability and tension, this book looks a-historically at mannerism to investigate what it can tell us about continental modal metaphysics, focusing in particular on its artificial and what (...) Van Tuinen calls 'secondary' nature. In three main parts, Van Tuinen first explores the ontology, aesthetics and ethics of mannerism. He then develops this through an extended study of Leibniz as a modal and indeed mannerist philosopher, before outlining in the final part a (neo)-mannerist aesthetics that incorporates diagrammatics, alchemy and contemporary technologies of speculative design. Drawing on Bergson, Simondon, Deleuze, Stengers and Agamben, together with artworks from Lomazzo to Arcimboldo, The Philosophy of Mannerism uncovers the rich new pathways created by the combination of philosophy, art history and contemporary theory. (shrink)

This paper presents the design and first result of a longitudinal case study on the change process from mainstream to sustainability of a Hotel Restaurant in The Netherlands. In this paper, after a brief introduction on the Hotel Restaurant and the chosen theoretical frame, the first steps in the research process will be presented including a sketch of the situation before the new executive chef officially took the insigne of the Hotel Restaurant executive chef; the management hypothesis; the plans of (...) the executive chef and the changes in the first months at HR. (shrink)

In this paper we introduce the overlapping design consensus for the construction of models in design and the related value judgments. The overlapping design consensus is inspired by Rawls’ overlapping consensus. The overlapping design consensus is a well-informed, mutual agreement among all stakeholders based on fairness. Fairness is respected if all stakeholders’ interests are given due and equal attention. For reaching such fair agreement, we apply Rawls’ original position and reflective equilibrium to modeling. We argue that by striving for the (...) original position, stakeholders expel invalid arguments, hierarchies, unwarranted beliefs, and bargaining effects from influencing the consensus. The reflective equilibrium requires that stakeholders’ beliefs cohere with the final agreement and its justification. Therefore, the overlapping design consensus is not only an agreement to decisions, as most other stakeholder approaches, it is also an agreement to their justification and that this justification is consistent with each stakeholders’ beliefs. For supporting fairness, we argue that fairness qualifies as a maxim in modeling. We furthermore distinguish values embedded in a model from values that are implied by its context of application. Finally, we conclude that for reaching an overlapping design consensus communication about properties of and values related to a model is required. (shrink)