The article discusses the accusation advanced by Plutarch and Cicero, according to which the Epicureans are unjust, as they would break the law to pursue pleasure if certain of impunity, and deals with this criticism by analyzing the Epicurean theory of law and justice and comparing it with friendship. The article argues that, from a doctrinal standpoint, philia has a higher place in the Epicurean’s priorities and a stronger efficacy than positive law in serving the naturally just. It thus concludes (...) that, as Plutarch and Cicero suspected, the Epicurean’s ultimate loyalty does not lie with positive law, in spite of its importance for social order, but rather with the naturally just, better secured by friendship. (shrink)

The present study provides an analysis of Socrates’ account of the first polis in Republic 2 as a thought experiment and draws attention to the fact that Socrates combines both explanatory and evaluative aspects in his scenario. The paper further shows how the analysis of the city of pigs as a thought experiment can explain the lack of pleonexia by saving both the letter of the text, according to which there are no “pleonectic” desires in the city of pigs, and (...) the fact that the first polis is nonetheless concerned with human beings. For, in contrast to the account offered by Glaucon earlier in Book 2, Socrates highlights our needs and lack of self-sufficiency as well as our compatibility with an advantageous and happy life in a community. (shrink)

This paper develops and articulates a metaphysics of intersectionality, the idea that multiple axes of social oppression cross-cut each other. Though intersectionality is often described through metaphor, theories of intersectionality can be formulated using the tools of contemporary analytic metaphysics. A central tenet of intersectionality theory, that intersectional identities are inseparable, can be framed in terms of explanatory unity. Further, intersectionality is best understood as metaphysical and explanatory priority of the intersectional category over its constituents, akin to metaphysical priority of (...) the whole over its parts. (shrink)

This paper examines both creepiness and the distinctive reaction had to creepiness, being “creeped out.” The paper defends a response-dependent account of creepiness in terms of this distinctive reaction, contrasting our preferred account to others that might be offered. The paper concludes with a discussion of the value of detecting creepiness.

Implantable neurotechnology devices such as Brain Computer Interfaces and Deep Brain Stimulators are an increasing part of treating or exploring potential treatments for neurological and psychiatric disorders. While only a few devices are approved, many promising prospects for future devices are under investigation. The decision to participate in a clinical trial can be challenging, given a variety of risks to be taken into consideration. During the consent process, prospective participants might lack the language to consider those risks, feel unprepared, or (...) simply not know what questions to ask. One tool to help empower participants to play a more active role during the consent process is a Question Prompt List. QPLs are communication tools that can prompt participants and patients to articulate potential concerns. They offer a structured list of disease, treatment, or research intervention-specific questions that research participants can use as support for question asking. While QPLs have been studied as tools for improving the consent process during cancer treatment, in this paper, we suggest they would be helpful in neurotechnology research, and offer an example of a QPL as a template for an informed consent tool in neurotechnology device trials. (shrink)

Reflections on moral discourse and its contexts are provided and the authors discuss the nature and tasks of moral philosophy. The collection creates a dialogue between different philosophical views.

In lieu of an abstract, here is a brief excerpt of the content:“An Equivocal Couple Overwhelmed by Life”A Phenomenological Analysis of PregnancySara HeinämaaTwo conceptions of human generativity prevail in contemporary feminist philosophy. First, several contributors argue that the experience of pregnancy, when analyzed by phenomenological tools, undermines several distinctions that are central to Western philosophy, most importantly the subject-object distinction and the self-other and own-alien distinctions. This line of argument was already outlined by Iris Marion Young in her influential essay (...) “Pregnant Embodiment: Subjectivity and Alienation” (1984). The other dominant argument is related to the first one, and it states that organic birth is the event that establishes the first experiential separation between the self and the other. On this understanding, the mother-fetus relation would not involve any relations between two corporeal selves; all such relations would be postnatal. This notion has been defended, for example, by Christine Schües (1997; 2000) and Johanna Oksala (2003).1On the other hand, classical phenomenology is dominated by the idea that the rigorous first-person methodology that is essential to phenomenology dictates that the sense of birth must be studied primarily by reflection on the structures of our own recollection or memory. Consequently, the primary sense of human birth would be that of an unattainable limit. This is argued on the basis of the existential fact that we all are born but cannot recall our own birth, or else on the basis of the transcendental fact that the structure [End Page 31] of retention ties each living present to an earlier one and implies that the transcendental ego cannot be subject to generation.2 From this perspective, all analyses and reflections of the experiences of labor, gestation, and pregnancy would be secondary since the sense of birth that these experiences involve is the nativity of another human being and not the nativity of the reflecting self.This paper challenges both the feminist and the classical phenomenological approach. I maintain that careful phenomenological analyses of the experience of pregnancy undermine both notions. Such analyses show, on the one hand, that pregnancy does not imply a nondistinction or self-other fusion but on the contrary involves a specific self-other divide. At the same time, they demonstrate that the sense of birth is more complex than the classical recollection-paradigm suggests and that it includes more components than the signification of an unattainable limit. A proper phenomenology of birth must take into account not only the universal fact that we all are born, but also the equally universal fact that each of us is born from another human being, that is, some other human subject.3 This other human being who “gave” us birth or “from whose flesh we were born” provides us with a unique perspective on our own past, beyond the limits of our own recollection. Her perspective is incomparable to any other external perspective; rather than simply giving us an additional third-person viewpoint on our own organic birth, this one person is able to open a second-person perspective on our pre- and postnatal life and the transition between them—all of which is beyond our own recollection.My argument proceeds by the following steps:First, I develop a fresh discourse on the experience of pregnancy, by studying a set of remarks to be found in Julia Kristeva’s postphenomenological discourse on maternity, on the one hand, and in Simone de Beauvoir’s existential-phenomenological discourse on feminine embodiment, on the other hand. I use these remarks as leading clues for a novel phenomenological study of the experience of pregnancy.4 Contra Young’s influential account mentioned above, I argue that gestation, as experienced by women who live it in the first person, includes a separation between two sensory-motor beings in a nesting relation: the pregnant self and the embryonic other. The alternative account that I provide hinges on my analysis of the experience of fetal movements and the role of touch-sensations and kinesthetic sensations in such experiences. Ultimately, I argue that pregnancy does not erode the self-other boundary or the own-alien boundary but reestablishes both divisions.Second, I compare my account of the experience of pregnancy to Merleau... (shrink)

Background: Growing evidence suggests that collaborative practice improves healthcare outcomes, but the precursors to collaborative behavior between nurses and physicians have not been fully explored. Research question: The purpose of this descriptive correlational study was to describe the professional values held by nurses and their attitudes toward physician–nurse collaboration and to explore the relationships between nurses’ characteristics (e.g. education, type of work) and professional values and their attitudes toward nurse–physician collaboration. Research design: This descriptive correlational study examines the relationship between (...) nurses’ professional values (Nurses Professional Values Scale–Revised) and their attitudes toward nurse–physician collaboration (Jefferson Scale of Attitudes toward Physician–Nurse Collaboration). Ethical considerations: Permission to conduct the study was received from the hospital, and the Institutional Review Boards of the healthcare system and the participating university. Participants/context: A convenience sample of 231 registered nurses from a tertiary hospital in the United States was surveyed. Findings: A significant positive relationship was found between nurses’ professional values and better attitudes toward collaboration with physicians ( r =.26, p <.01). Attitude toward collaboration with physicians was also positively associated with master’s or higher levels of education ( F(3, 224) = 4.379, p =.005). Discussion: The results of this study can be helpful to nurse administrators who are responsible for developing highly collaborative healthcare teams and for nurse educators who are focused on developing professional values in future nurses. (shrink)

In their paper, Chapman and colleagues (2025) argue how key regulations and “data-centric” research practices neglect to address potential group harms. They utilize the case of genomic research on...

Dialogue semantics for logic are two-player logic games between a Proponent who puts forward a logical formula φ as valid or true and an Opponent who disputes this. An advantage of the dialogical approach is that it is a uniform framework from which different logics can be obtained through only small variations of the basic rules. We introduce the composition problem for dialogue games as the problem of resolving, for a set S of rules for dialogue games, whether the set (...) of S-dialogically valid formulas is closed under modus ponens. Solving the composition problem is fundamental for the dialogical approach to logic; despite its simplicity, it often requires an indirect solution with the help of significant logical machinery such as cut-elimination. Direct solutions to the composition problem can, however, sometimes be had. As an example, we give a set N of dialogue rules which is well-justified from the dialogical point of view, but whose set N of dialogically valid formulas is both non-trivial and non-standard. We prove that the composition problem for N can be solved directly, and introduce a tableaux system for N. (shrink)

Some psychological states—paradigmatically, beliefs and intentions—are rationally evaluable: they can be rational or irrational, justified or unjustified. Other states—e.g. sensations and gastrointestinal states—aren't: they're a‐rational. On a familiar but hard‐to‐make‐precise line of thought, at least part of what explains this difference is that we're somehow responsible for (having/being in) states of the former sort, in a way we're not for the others. But this responsibility can't be modeled on the responsibility we have for our (free, intentional) actions. So how should (...) it be understood? In this paper I address that question. The overall shape of my answer is in line with tradition: I take the responsibility to be grounded in certain capacities for reflection and control. Answers in this family have recently been subjected to an interesting challenge. But the version I defend meets that challenge. (shrink)

Though Arthur Prior is now best known for his founding of modern temporal logic and hybrid logic, much of his early philosophical career was devoted to history of logic and historical logic. This interest laid the foundations for both of his ground-breaking innovations in the 1950s and 1960s. Because of the important rôle played by Prior's research in ancient and medieval logic in his development of temporal and hybrid logic, any student of Prior, temporal logic, or hybrid logic should be (...) familiar with the medieval logicians and their work. In this article we give an overview of Prior's work in ancient and medieval logic. (shrink)

Several commentators have argued that with his concept of anonymity Merleau-Ponty breaks away from classical Husserlian phenomenology that is methodologically tied to the first person perspective. Many contemporary commentators see Merleau-Ponty’s discourse on anonymity as a break away from Husserl’s framework that is seen as hopelessly subjectivistic and solipsistic. Some judge and reproach it as a disastrous misunderstanding that leads to a confusion of philosophical and empirical concerns. Both parties agree that Merleau-Ponty’s concepts of anonymity mark a divergence from classical (...) Husserlian phenomenology. I will question this view and demonstrate that Merleau-Ponty’s discourse on anonymity remains Husserlian in two important senses: it analyses senses in terms of constituting selves and communities of such selves, and it accounts for the formation of experience by the temporal sedimentation of intentional activity. The argument proceeds in four steps. The first section argues against the widely spread notion according to which Merleau-Ponty’s anonymous subject is collective. In the second section, I offer an alternative reading by demonstrating that Merleau-Ponty uses the term “anonymous” primarily to characterize the lived body of a personal subject. In section three, I introduce Merleau-Ponty’s idea of trace and show that for him both the perceived thing and the perceiving body are traces and as such refer to earlier constitutive acts of alien subjects. I then argue that Husserl’s concepts of sedimentation are crucial for the understanding of this idea. Finally, in section four, I show how Husserl’s theory of depresentation informs Merleau-Ponty’s discourse on anonymity. (shrink)

The aim of this paper is to investigate, if there is a principal disagreement between Husserl's early concept of expression and his later discussions on gestures. In the early work Logical Investigations (1900–1901), Husserl quite bluntly excludes gestures from the category of meaningful expressions; thirty years later (1928), in the second volume of Ideas, he argues to the contrary that gestures are meaningful and expressive in the very same way as linguistic units, words and sentences. The question of this paper (...) is: What happened in Husserl's thinking in the two decades between Investigations and the last versions of Ideas II? I argue that the disagreement between Husserl's early statement and his later discussion on gestural expressions is due to a refinement in his account of embodiment. I claim that Husserl did not abandon his concept of expression, but dismissed his early analysis of embodiment as simplistic and as motivated by a certain preconception about the relationship between nature and spirit. This change became possible for him as he developed conceptual and methodic tools for distinguishing between different meanings of the body: the physical thing or the mere material body, the perceived body, and the sensuous body. The difference between the body as a physical thing and the body as a sensuous-spiritual unit proves to be crucial to the understanding of gestural expressions. (shrink)

This chapter develops an alternative to the dominant articulation of human existence on the basis of classical phenomenology, arguing that Edmund Husserl's phenomenological inquiries into the structures of embodiment provide a very different and more fruitful starting point for the investigation of sexual difference than the ideas of social gender and biological sex. The ways of classifying sex and gender characteristics mark them out on several different conceptual bases, and thus their categories may not correspond or coincide. Moreover historical and (...) biological inquiries indicate that the dimorphic notion of sex is prescriptive and constructive. Finally the sex/gender paradigm is dominated by the explanatory framework of causes and effects. The phenomenological analysis shows that the causal-functional framework is inadequate for the investigation of the plurality of the bodily existence and sexual difference as a dimension of this existence. In the light of the explication of the concepts of sex and gender, and the phenomenological analysis of embodiment, the sex/gender paradigm cannot offer a basis for a comprehensive philosophy of sexual existence. (shrink)

The aim of this volume is to offer an updated account of the transcendental character of phenomenology. The main question concerns the sense and relevance of transcendental philosophy today: What can such philosophy contribute to contemporary inquiries and debates after the many reasoned attacks against its idealistic, aprioristic, absolutist and universalistic tendencies—voiced most vigorously by late 20th century postmodern thinkers—as well as attacks against its apparently circular arguments and suspicious metaphysics launched by many analytic philosophers? Contributors also aim to clarify (...) the relations of transcendental phenomenology to other post-Kantian philosophies, most importantly to pragmatism and Wittgenstein’s philosophical investigations. Finally, the volume offers a set of reflections on the meaning of post-transcendental phenomenology. (shrink)

Beller, Bender, and Medin (this issue) offer a provocative proposal outlining several reasons why anthropology and the rest of cognitive science might consider parting ways. Among those reasons, they suggest that separation might maintain the diversity needed to address larger problems facing humanity, and that the research strategies used across the disciplines are already so diverse as to be incommensurate. The present paper challenges the view that research strategies are incommensurate and offers a multimethod approach to cultural research that can (...) help to establish common ground while maintaining diversity. (shrink)

At the beginning of Being and Time, Heidegger rejects Husserl’s classical phenomenology on three grounds: he claims that Husserlian phenomenology is impaired by indeterminate concepts, by naïve personalism, and by obscurities in its account of individuation. The paper studies the validity of this early critique by explicating Husserl’s discourse on human persons as bodily-spiritual beings and by clarifying his account of the principles by which such beings can be individuated. The paper offers three types of considerations. After a summary of (...) Heidegger’s early critique of Husserl, the second section of the paper distinguishes between two dimensions of Husserl’s discourse on human persons. It argues that Husserl does not put forward one analysis of the being of humans, but explicates two different accounts and then studies critically their mutual relations of dependency: on the one hand, the naturalistic account of human beings as layered beings and on the other hand the personalistic account of human beings as peculiar kinds of unified wholes in which the mental and the bodily are inextricably intertwined. The third section of the paper clarifies Husserl’s theory of individuation and its consequences for our discourse on human persons. Finally, the fourth section explicates the conceptual means by which Husserl develops his account of human beings as persons. The paper ends in drawing some conclusions for contemporary philosophical anthropology. (shrink)

This paper problematizes the analogy that Hubert Dreyfus has presented between phenomenology and cognitive science. It argues that Dreyfus presents Merleau-Ponty''s modification of Husserl''s phenomenology in a misleading way. He ignores the idea of philosophy as a radical interrogation and self-responsibility that stems from Husserl''s work and recurs in Merleau-Ponty''s Phenomenology of Perception. The paper focuses on Merleau-Ponty''s understanding of the phenomenological reduction. It shows that his critical idea was not to restrict the scope of Husserl''s reductions but to study (...) the conditions of possibility for the thetic acts. Merleau-Ponty argued, following Husserl''s texts, that the thetic acts rest on the basis of primordial pre-thetic experience. This layer of experience cannot, by its nature, be explicated or clarified, but it can be questioned and unveiled. This is the recurrent task of phenomenological philosophy, as Merleau-Ponty understands it. (shrink)

_ Source: _Volume 23, Issue 2, pp 196 - 235 The role of choice in Gersonides’ theory of miracles, as presented in the Wars of the Lord, is discussed. The theory of miracles in Wars vi.2.10 is shown to be another link in his reconciliation of determinism with choice. After a brief review of his ideas about choice, his astral determinism is elucidated. The third part of the essay reviews his treatment of how miracles occur. Gersonides is shown to have (...) established a “conditional miraculous determinism”; his concern for choice is the key to this solution. (shrink)

Summary Ferdinand von Mueller (1825–96), the German-born Government Botanist of Victoria from 1853 until his death, and concurrently Director of the Melbourne Botanic Garden from 1857 until 1873, was a prolific systematic botanist, but also heavily involved in public educational activities. He conceived of the Garden as an educative place of recreation, but ultimately lost control over it. His loss did not stop his popular writing and lecturing, especially in areas related to the application of botany in horticulture, agriculture, and (...) forestry. The structure of his introductory school text—very different from the intensely logical grammar-like botany texts of the period—owed much to his political masters, but it is characterized by careful attention to language and locality. Mueller's work represents a consistent and pervasive example of attention to the ‘public understanding of science’ that resonates with the concerns of early twenty-first-century funders of scientific research. (shrink)

Background: Direct–to–consumer genetic testing (DTCGT) offers risk estimates for a variety of complex diseases and conditions, yet little is known about its impact on actual users, including their decisions about sharing the information gleaned from testing. Ethical considerations include the impact of unsolicited genetic information with variable validity and clinical utility on relatives, and the possible burden to the health care system if revealed to physicians. Aims: The qualitative study explored primary care patients’ views, attitudes, and decision making considerations regarding (...) DTCGT. This article focuses on the disclosure decisions participants made regarding participation, testing, and results of DTCGT, a topic which arose as a secondary aim of the study. Methods: Through four longitudinal interviews (pre–test, results, 3 and 12 months post–test) we examined twenty primary care patients’ decisions, expressed intentions, and actions regarding disclosure to immediate and extended family, friends and coworkers, and physicians about participation in and results of DTCGT. Individual interviews were analyzed using qualitative content analysis and a summative approach to describe the global themes. Results: Most participants disclosed to some immediate family; less than half disclosed to extended family; approximately half talked to friends. Most participants stated they would or might disclose to physicians about DTCGT and a few did. Conceptual themes that emerged from the data analysis include ambivalence about disclosure, consistency between intention and actual disclosure behavior and decisions, and conditional information sharing. Conclusions: Participants’ intentional and actual disclosure patterns offer insight into how they view DTCGT, weigh results, and the potential impact of DTCGT. (shrink)

Recently logic has shifted emphasis from static systems developed for purely theoretical reasons to dynamic systems designed for application to real world situations. The emphasis on the applied aspects of logic and reasoning means that logic has become a pragmatic tool, to be judged against the backdrop of a particular application. This shift in emphasis is, however, not new. A similar shift towards “interactive logic” occurred in the high Middle Ages. We provide a number of different examples of “interactive logic” (...) in the Middle Ages, all species of the disputation game obligatio. These games display a recognition of the importance of interaction in logical contexts and the way that interactive logic differs from single-agent inference. (shrink)

The medieval distinction between categorematic and syncategorematic words is usually given as the distinction between words which have signification or meaning in isolation from other words and those which have signification only when combined with other words . Some words, however, are classified as both categorematic and syncategorematic. One such word is Latin infinita ‘infinite’. Because infinita can be either categorematic or syncategorematic, it is possible to form sophisms using infinita whose solutions turn on the distinction between categorematic and syncategorematic (...) uses of infinita. As a result, medieval logicians were interested in identifying correct logical rules governing the categorematic and syncategorematic uses of the term. In this paper, we look at 13th–15th-century logical discussions of infinita used syncategorematically and categorematically. We also relate the distinction to other medieval distinctions with which it has often been conflated in modern times, and show how and where these conflations go wrong. (shrink)

The current trend in knowledge revision in the Dynamic Epistemic Logic tradition focuses on the addition of new knowledge, rather than the possibility of losing knowledge. Yet there are natural situations, such as an agent who does not want another agent to know that she knows a certain piece of information, where there is a need to be able to model the retraction of a proposition from a knowledge base. One situation where this is systematically required is the variant of (...) the medieval theory of obligationes known as dubitatio, where one of the agents in the dialogue is obliged to hold the initial proposition, the dubitatum, as doubtful, regardless of what other propositions she may concede or deny during the disputation. In this paper, we use dubitatio as a motivation for studying deceitful agents, and we discuss various ways that an agent can move from a model where f is known to one where f is not known. (shrink)

The struggle to delineate the relationship between theology and logic flourished in the thirteenth century and culminated in two condemnations in early 1277, one in Paris and the other in Oxford. To see how much and what kind of effect ecclesiastical actions such as condemnations and prohibitions to teach had on the development of logic in the Middle Ages, we investigate the events leading up to the 1277 actions, the condemned propositions, and the parts of these condemnations connected to modal (...) and temporal logic specifically. We show that because of the specific motivations late thirteenth-century and fourteenth-century logicians had when working in modal and temporal logic, the effect of the 1277 condemnations on the development of those branches was much smaller than might have been supposed. (shrink)

El artículo describe aspectos significativos de la conformación histórica del método clínico y hace referencia a personalidades que influyeron desde la medicina hipocrática hasta el siglo XX, detallándose los valores éticos y morales que lo caracterizaban y sus desafíos ante la sociedad. Se significa la necesidad de una reforma de pensamiento de los profesionales de la Medicina, que permita abrir nuevas perspectivas y contribuya a la reflexión siendo revertido en una conducta humanista y atención médica con calidad, con la respectiva (...) satisfacción de la población tal como se pide en los lineamientos del Partido. The article describes significant aspects of the historical formation of the clinical method and refers to personalities that influenced since The Hippocratic Medicine until the 20th Century, making emphasis on the ethical and moral values that characterized it and its challenges before the society. The need for a reform of the medical professionals thinking is meant, which allows to open new perspectives and contributes to the reflection being reversed in a humanist behaviour and a qualified medical care, with the respective satisfaction of the population as requested in the guidelines of the party. (shrink)

The development of the Area of Freedom, Security and Justice has transformed the European Union and placed fundamental rights at the core of EU integration and its principles of mutual recognition and trust. The impact of the AFSJ in the development of an EU standard of fundamental rights, which has come to the fore since the Treaty of Lisbon, is a topic of great theoretical and practical importance. This is the first systematic academic study of the AFSJ and its implications (...) from the point of view of fundamental rights. The contributions to this collection examine the normative and jurisprudential development of the AFSJ in order to assess its effects on the overall construction of the scope and standards of protection of EU fundamental rights in this particularly complex and sensitive field of integration. The expert contributors systematically map and critically assess this area of EU law, together with the relevant case-law. (shrink)

Research on dyscalculia in neurodegenerative diseases is still scarce, despite high impact on patients’ independence and activities of daily living function. Most studies address Alzheimer’s Disease; however, patients with Parkinson’s Disease also have a higher risk for cognitive impairment while the relation to arithmetic deficits in financial contexts has rarely been studied. Therefore, the current exploratory study investigates deficits in two simple arithmetic tasks in financial contexts administered within the Clinical Dementia Rating in a sample of 100 PD patients. Patients (...) were classified as cognitively normal or mildly impaired according to Level I consensus criteria, and assessed using a comprehensive neuropsychological test battery, neurological motor examination, and sociodemographic and clinical questionnaires. In total, 18% showed arithmetic deficits: they were predominately female, had longer disease duration, more impaired global cognition, but minor signs of depression compared to PD patients without arithmetic deficits. When correcting for clinical and sociodemographic confounders, greater impairments in attention and visuo-spatial/constructional domains predicted occurrence of arithmetic deficits. The type of deficit did not seem to be arbitrary but seemed to involve impaired place × value processing frequently. Our results argue for the importance of further systematic investigations of arithmetic deficits in PD with sensitive tests to confirm the results of our exploratory study that a specific subgroup of PD patients present themselves with dyscalculia. (shrink)

Temporal logic as a modern discipline is separate from classical logic; it is seen as an addition or expansion of the more basic propositional and predicate logics. This approach is in contrast with logic in the Middle Ages, which was primarily intended as a tool for the analysis of natural language. Because all natural language sentences have tensed verbs, medieval logic is inherently a temporal logic. This fact is most clearly exemplified in medieval theories of supposition. As a case study, (...) we look at the supposition theory of Lambert of Lagny, extracting from it a temporal logic and providing a formalization of that logic. (shrink)

Formal dialogue systems model rule-based interaction between agents and as such have multiple applications in multi-agent systems and AI more generally. Their conceptual roots are in formal theories of natural argumentation, of which Hamblin’s formal systems of argumentation in Hamblin (Fallacies. Methuen, London, 1970, Theoria 37:130–135, 1971) are some of the earliest examples. Hamblin cites the medieval theory of obligationes as inspiration for his development of formal argumentation. In an obligatio, two agents, the Opponent and the Respondent, engage in an (...) alternating-move dialogue, where the Respondent’s actions are governed by certain rules, and the goal of the dialogue is establishing the consistency of a proposition. We implement obligationes in the formal dialogue system framework of Prakken (Knowl Eng Rev 21(2):163–188, 2006) using Dynamic Epistemic Logic (van Ditmarsch et al. in Dynamic epistemic logic, Synthese Library Series. Springer, Berlin, 2007). The result is a new type of inter-agent dialogue, for consistency-checking, and analyzing obligationes in this way also sheds light on interpretational and historical questions concerning their use and purpose in medieval academia. (shrink)

We present Prior's discussion of a puzzle about valditity found in the writings of the fourteenth-century French logician Jean Buridan and show how Prior's study of this puzzle may have provided the conceptual inspiration for his development of hybrid logic.

Abnormalities in the ability of cells to properly degrade proteins have been identified in many neurodegenerative diseases. Recent work has implicated synaptojanin 1 (SynJ1) in Alzheimer's disease and Parkinson's disease, although the role of this polyphosphoinositide phosphatase in protein degradation has not been thoroughly described. Here, we dissected in vivo the role of SynJ1 in endolysosomal trafficking in zebrafish cone photoreceptors using a SynJ1‐deficient zebrafish mutant, nrca14. We found that loss of SynJ1 leads to specific accumulation of late endosomes and (...) autophagosomes early in photoreceptor development. An analysis of autophagic flux revealed that autophagosomes accumulate because of a defect in maturation. In addition we found an increase in vesicles that are highly enriched for PI(3)P, but negative for an early endosome marker in nrca14 cones. A mutational analysis of SynJ1 enzymatic domains found that activity of the 5'phosphatase, but not the Sac1 domain, is required to rescue both aberrant late endosomes and autophagosomes. Finally, modulating activity of the PI(4,5)P2 regulator, Arf6, rescued the disrupted trafficking pathways in nrca14 cones. Our study describes a specific role for SynJ1 in autophagosomal and endosomal trafficking and provides evidence that PI(4,5)P2 participates in autophagy in a neuronal cell type. -/- . (shrink)

Journal Name: Apeiron Issue: Ahead of print.

In the 4th century BC, the Greek philosopher Diodoros Chronos gave a temporal definition of necessity. Because it connects modality and temporality, this definition is of interest to philosophers working within branching time or branching space-time models. This definition of necessity can be formalized and treated within a logical framework. We give a survey of the several known modal and temporal logics of abstract space-time structures based on the real numbers and the integers, considering three different accessibility relations between spatio-temporal (...) points. (shrink)