In the organelles of plants and mammals, recent evidence suggests that genomic instability stems in large part from template switching events taking place during DNA replication. Although more than one mechanism may be responsible for this, some similarities exist between the different proposed models. These can be separated into two main categories, depending on whether they involve a single‐strand‐switching or a reciprocal‐strand‐switching event. Single‐strand‐switching events lead to intermediates containing Y junctions, whereas reciprocal‐strand‐switching creates Holliday junctions. Common features in all the (...) described models include replication stress, fork stalling and the presence of inverted repeats, but no single element appears to be required in all cases. We review the field, and examine the ideas that several mechanisms may take place in any given genome, and that the presence of palindromes or inverted repeats in certain regions may favor specific rearrangements. (shrink)

Pendant plus de dix ans, chacun dans son coin, Marie-Pierre, Gérôme et Samuel ont consacré leur temps libre à des fanzines sur la musique. Jusqu’à ce qu’en 1998 Samuel se lance dans la publication de travaux de jeunes chercheurs en Lettres et en Sciences humaines et fonde les éditions Mélanie Séteun – anagramme et nom de plume de Samuel Étienne. Nombre de manuscrits qu’il reçoit ne sont pas publiables _in extenso. _Il songe alors à un livre (...) collectif. L’IRMA, diffuseur des éditions, rectifie le tir. Aucun périodique n’est consacré aux recherches pluridisciplinaires sur les musiques actuelles et amplifiées? Le livre collectif sera donc une revue. Samuel s’adjoint Marie-Pierre et Gérôme pour diriger les opérations. Et les voilà à l’heure de la parution du premier numéro de _Copyright Volume! _Il présente, toutes disciplines confondues, des articles de réflexion écrits par des universitaires, des témoignages de professionnels et d’institutionnels ainsi que des propositions plastiques d’a... (shrink)

I provide an analysis of sentences of the form ‘To beFis to beG’ in terms of exact truth-maker semantics—an approach that identifies the meanings of sentences with the states of the world directly responsible for their truth-values. Roughly, I argue that these sentences hold just in case that which makes somethingFalso makes itG. This approach is hyperintensional and possesses desirable logical and modal features. In particular, these sentences are reflexive, transitive, and symmetric, and if they are true, then they are (...) necessarily true, and it is necessary that all and onlyFs areGs. I motivate my account over Correia and Skiles’ [11] prominent alternative and close by defining an irreflexive and asymmetric notion of analysis in terms of the symmetric and reflexive notion. (shrink)

In Book II, Chapter xxi of An essay concerning human understanding, Locke claims that a mind's will is its power 'to order the consideration of any Idea, or the forbearing to consider it; or to prefer the motion of any part of the body to its rest, and vice versa in any particular instance' (Il. xxi. 5).l To exercise this power (that is, to will), Locke says, is to perform an act of volition (or: willing), volitions being actions of the (...) mind directed to the performance of other actions (of the mind or body). Locke claims further that a man's being free (or at liberty) with respect to some action A is his having the power to perform or to forbear performing A according to his volition in the matter (8). Thus, X is free with respect to A if and onty if (i) X is able to perform A if he wills to perform A and (ii) X is able not to perform A if he wills not to perform A. This analysis of freedom. (shrink)

Theoretical virtues play an important role in the acceptance and belief of theories in science and philosophy. Philosophers have well-developed views on which virtues ought and ought not to influence one’s acceptance and belief. But what do scientists think? This paper presents the results of a quantitative study with scientists from the natural and social sciences and compares their views to those held by philosophers. Some of the more surprising results are: all three groups have a preference order regarding theoretical (...) virtues, making theory choice a much more determinate matter than what has sometimes been suggested; the preference orders are very similar for the three groups; simplicity is viewed as an epistemic virtue particularly by social scientists ; and syntactic parsimony is preferred to ontological parsimony by all three groups. (shrink)

Marxism has often been associated with two different legacies. The first rests on a strong exposition and critique of the logic of capitalism, grounded in a systematic analysis of the laws of motion of capitalism as a system. The second legacy refers to a strong historicist perspective grounded in a conception of social relations that emphasises the centrality of power and social conflict to the analysis of history. This article challenges the prominence of structural accounts of capitalism by showing how (...) the tension between these legacies has played out within Political Marxism, both orientations already having co-existed, somewhat uneasily, within Robert Brenner’s original contributions to the Transition Debate. Through this internal critique and re-formulation of Political Marxism, we wish to open a broader debate within Marxism on the need for a more agency-based account of capitalism, which builds more explicitly on the concept of social relations, to recover the historicist legacy of Marxism. (shrink)

Essayer de degager l'esprit de la philosophie medievale c'etait se condamner a fournir la preuve de son existence ou a avouer qu'elle n'a jamais existe. C'est en cherchant a la definir dans son essence propre que je me suis vu conduit a la presenter comme la philosophie chretienne par excellence. Il se trouve donc que cet ouvrage converge vers cette conclusion, que le Moyen Age a produit, outre une litterature chretienne et un art chretien, une philosophie chretienne, ce dont on (...) dispute. Mais il ne s'agit pas de soutenir qu'il a cree cette philosophie de rien, pas plus qu'il n'a tire du neant son art et sa litterature. L'esprit de la philosophie medievale, tel qu'on l'entend ici, c'est l'esprit chretien, penetrant la tradition grecque, la travaillant du dedans et lui faisant produire une vue du monde, une Weltanschauung specifiquement chretienne. (shrink)

I argue that Spinoza endorses "conceptual dependence monism," the thesis that all forms of metaphysical dependence (such as causation, inherence, and existential dependence) are conceptual in kind. In the course of explaining the view, I further argue that it is actually presupposed in the proof for his more famed substance monism. Conceptual dependence monism also illuminates several of Spinoza’s most striking metaphysical views, including the intensionality of causal contexts, parallelism, metaphysical perfection, and explanatory rationalism. I also argue that this priority (...) of the conceptual does not commit Spinoza to forms of idealism or mentalism. The question of how to understand different kinds of metaphysical dependence is quite controversial in Spinoza studies; I address major alternative readings in the notes. But there I also try to draw connections to the growing debate in contemporary discussions about metaphysical dependence, as this topic is a happy point of shared interest between Spinoza and contemporary metaphysicians alike. (shrink)

Some philosophers argue that we should eschew cross-explanatory integrations of mechanistic, dynamicist, and psychological explanations in cognitive science, because, unlike integrations of mechanistic explanations, they do not deliver genuine, cognitive scientific explanations. Here I challenge this claim by comparing the theoretical virtues of both kinds of explanatory integrations. I first identify two theoretical virtues of integrations of mechanistic explanations—unification and greater qualitative parsimony—and argue that no cross-explanatory integration could have such virtues. However, I go on to argue that this is (...) only a problem for those who think that cognitive science aims to specify one fundamental structure responsible for cognition. For those who do not, cross-explanatory integration will have at least two theoretical virtues to a greater extent than integrations of mechanistic explanations: explanatory depth and applicability. I conclude that one’s views about explanatory integration in cognitive science cannot be segregated from one’s views about the explanatory task of cognitive science. (shrink)

This flexible introductory textbook explores several key themes in philosophy, and helps the reader learn to engage with the key arguments by introducing and analysing a selection of classic readings. Fully integrated introductory text with readings for beginning students of philosophy. Each chapter focusses on a core philosophical topic, and contains an introduction to the topic, 2 classic readings and interactive commentaries on the readings. An introductory book which doesn't merely _tell_ the reader about the subject, but requires them to (...) engage philosophically with the text. A pedagogical resource developed in the classroom by the authors at the University of London. (shrink)

A discussion of the importance of language in contemporary society.

To be a liberal is, among other things, to grant basic liberties some degree of priority over other aspects of justice. But why do basic liberties warrant this special treatment? For Rawls, the answer has to do with the allegedly special connection between these freedoms and the ‘two moral powers’ of reasonableness and rationality. Basic freedoms are said to be preconditions for the development and exercise of these powers and are held to warrant priority over other justice-relevant values for that (...) reason. In the first half of the article I mount an internal critique of this Rawlsian line, arguing that it is flawed in two main ways. First, it overestimates the contribution of basic freedom to moral personality. Second, it underestimates the contribution of non-liberty resources to moral personality. In the second half of the article I repair these flaws. The result is a new, intriguingly radical version of justice as fairness, one with surprising—yet plausible—implications for economic and gender justice. (shrink)

A new approach to uderstanding the ever-changing information that bombards us. Arbesman is an expert in scientometrics, literally the science of science--how we know what we know. It turns out that knowledge in most fields evolves in systematic and predictable ways, and understanding that evolution can enormously powerful.

First Published in 1999. Routledge is an imprint of Taylor & Francis, an informa company.

Le volume "Images de Platon et lectures de ses oeuvres" rassemble vingt et une contributions consacrees a diverses relectures qui ont ete faites de l'oeuvre ecrite de Platon entre le IIIe siecle (Diogene Laerce, Plotin) et le XXe sievle (K. Popper). Dans l'introduction, Ada Neschke met en lumiere le cheminement de ces relectures et souligne le fait que les lectures de Platon sont constamment alimentees par des preoccupations propres a ses lecteurs. Dans un premier temps, l'oeuvre de Platon est integree (...) dans une optique essentiellement theologique; apres l'avenement du kantisme, elle s'inscrit dans un cadre de pensee qui se veut critique et philosophique, c'est-a-dire emancipe de l'ancienne metaphysique. Ainsi, l'oeuvre de Platon represente, d'une part, pour les penseurs chretiens une source d'inspiration concernant les sujets les plus divers: la theologie chretienne (Clement d'Alexandrie, Ficin, les Platoniciens de Cambridge), la mytho-theologie neo-platonicienne (Plethon), l'iconographie de la trinite (Francisco di Hollanda), la politique catholique et le calviniste (Jean Bodin, Jean de Serres), le scepticisme face aux debats theologiques (Montaigne). D'autre part, Platon a la valeur d'une autorite pour les penseurs postkantiens, que ce soit pour construire une philosophie de la nature (Schelling), une ethique (Hegel), une epistemologie (les neo-kantiens Cohen et Natorp) ou encore une ontologie (Heidegger). Enfin, Platon sert de reference dans les debats politiques modernes et contemporains, en particulier dans les discussions sur le liberalisme (J. St. Mill) et le totalitarisme (Popper et ses successeurs). De l'antiquite jusqu'a nos jours, Platon reste donc un auteur qui interpelle son lecteur et lui lance meme souvent un defi. (shrink)

"Sam Rocha's primer reminds me of a French adage: la philo descends dans la rue--philosophy comes to the street. Rocha's little book can be read and talked about, with profit, on the street, in the home, in the school, in the garden, anywhere the human heart beats and the human mind thinks." --David T. Hansen, Weinburg Professor in the History and Philosophy of Education, Teachers College Columbia University "Rocha gives us a compelling experience of first-hand philosophizing, in which the ordinary (...) is shown in its powerful features, and the discipline of philosophy of education reclaims its necessity." --Cristina Cammarano, Assistant Professor of Philosophy, Salisbury University "Rocha's illustrated primer is an eye-opening introduction to the philosophy of education. And, unlike too many illustrated texts, its pen and ink drawings are a thought provoking complement to this highly readable introduction." --David Mosley, Professor of Philosophy, Bellarmine University "An elegantly written invitation to students and the general reader to a frame of mind where one is ready to learn from and think about philosophy and education. Sam Rocha calls us all back, in heart-felt yet precise prose, to philosophy's ancient role of dialogue, wonder, and reflection. A joy to read and treasure." --AG Rud, Distinguished Professor, Washington State University "A charming and clearly written introduction to the philosophy of education, inspired by the writings of William James." --Graham Harman, Associate Provost for Research Administration and Professor of Philosophy, The American University in Cairo.embed-container { position: relative; padding-bottom: 56.25%; height: 0; overflow: hidden; max-width: 100%; }.embed-container iframe,.embed-container object,.embed-container embed { position: absolute; top: 0; left: 0; width: 100%; height: 100%; }. (shrink)

We propose that, for the purpose of studying theoretical properties of the knowledge of an agent with Artificial General Intelligence (that is, the knowledge of an AGI), a pragmatic way to define such an agent’s knowledge (restricted to the language of Epistemic Arithmetic, or EA) is as follows. We declare an AGI to know an EA-statement φ if and only if that AGI would include φ in the resulting enumeration if that AGI were commanded: “Enumerate all the EA-sentences which you (...) know.” This definition is non-circular because an AGI, being capable of practical English communication, is capable of understanding the everyday English word “know” independently of how any philosopher formally defines knowledge; we elaborate further on the non-circularity of this circular-looking definition. This elegantly solves the problem that different AGIs may have different internal knowledge definitions and yet we want to study knowledge of AGIs in general, without having to study different AGIs separately just because they have separate internal knowledge definitions. Finally, we suggest how this definition of AGI knowledge can be used as a bridge which could allow the AGI research community to import certain abstract results about mechanical knowing agents from mathematical logic. (shrink)

We show that if a countable structure M in a finite relational language is not cellular, then there is an age-preserving $N \supseteq M$ such that $2^{\aleph _0}$ many structures are bi-embeddable with N. The proof proceeds by a case division based on mutual algebraicity.

This essay engages with two large themes in order to address the social and intellectual practices of nyāya scholars in early colonial Bengal. First, I examine networks that connected scholars with each other and, to a lesser extent, students and households. Exemplified in historical documents of the period, these networks demonstrate that nyāya scholars were part of larger scholar communities in Bengal and across India during the eighteenth and nineteenth centuries. I map these networks and examine their relevance for how (...) nyāya scholars were organized in early colonial Bengal. Second, I examine circulation patterns of manuscripts of nyāya texts composed in eighteenth- and nineteenth-century Bengal. I argue that a contraction in the distribution of nyāya manuscripts of works written in Bengal during the eighteenth and nineteenth centuries took place, especially into southern India. The essay concludes by situating nyāya scholars within the context of colonialism and drawing larger conclusions about nyāya intellectual practices in Bengal during the eighteenth and nineteenth centuries. (shrink)