Koonin argues that CRISPR-Cas systems present the best-known case in point for Lamarckian evolution because they satisfy his proposed criteria for the specific inheritance of acquired adaptive characteristics. We see two interrelated issues with Koonin’s characterization of CRISPR-Cas systems as Lamarckian. First, at times he appears to confuse an account of the CRISPR-Cas system with an account of the mechanism it employs. We argue there is no evidence for the CRISPR-Cas system being “Lamarckian” in any sense. Second, it is unclear (...) whether the mechanism is more “Lamarckian” than many other forms of genetic change already well-characterized in Darwinian terms. We present three conceptually distinct senses in which the mechanism of IAC may be considered Lamarckian and argue that only the strongest sense of goal-directed IAC would be difficult to accommodate in a Darwinian account. As the CRISPR-Cas mechanism does not qualify as “Lamarckian” in this strong sense, we argue there is no conceptual value in calling it “Lamarckian”. Finally, we suggest that CRISPR-Cas systems do hold the potential for genuinely non-Darwinian, directed evolution in a way that Koonin did not discuss, involving their potential use as a human gene-editing tool. (shrink)

The visual system adapts to a wide range of visual features, from lower-level features like color and motion to higher-level features like causality and, perhaps, number. According to some, adaptation is a strictly perceptual phenomenon, such that the presence of adaptation licenses the claim that a feature is truly perceptual in nature. Given the theoretical importance of claims about adaptation, then, it is important to understand exactly when the visual system does and does not exhibit adaptation. Here, we take as (...) a case study one specific kind of adaptation: visual adaptation to size. Supported by evidence from four experiments, we argue that, despite robust effects of size adaptation in the lab, (1) size adaptation effects are phenomenologically underwhelming (in some cases, hardly appreciable at all), (2) some effects of size adaptation appear contradictory, and difficult to explain given current theories of size adaptation, and (3) prior studies on size adaptation may have failed to isolate size as the adapted dimension. Ultimately, we argue that while there is evidence to license the claim that size adaptation is genuine, size adaptation is a puzzling and poorly understood phenomenon. (shrink)

In this paper we challenge the idea that valid consent is the golden standard by which a sexual encounter is deemed ethical. We begin by reviewing the recent public focus on consent as an ethical standard, and then argue for a standard that goes beyond legalistic and contractual foci. This is the standard of mutuality which extends beyond the assurance that all parties engaging in a sexual encounter are informed, autonomous, and otherwise capable of making a valid choice: one must (...) also encounter the other with care and loving attention. We develop this claim using Iris Murdoch’s concept of an attitude of “loving attention,” which differentiates our view from the duty of due diligence to ensure that each person is a willing participant in sex, that the rights of others have not been violated, as emphasized by Dougherty. We also address three objections to using mutuality as a measure of ethical sex, namely that it is patronizing, that it is a maximalist position that puts too great a burden on individuals and inhibits their freedom, and that it is an ideal rather than a requirement. We then look at three examples that test the construct of mutuality: the typical college hook-up, sex work, and anonymous sex through glory holes and similar set-ups. (shrink)

Does the visual system adapt to number? For more than fifteen years, most have assumed that the answer is an unambiguous “yes”. Against this prevailing orthodoxy, we recently took a critical look at the phenomenon, questioning its existence on both empirical and theoretical grounds, and providing an alternative explanation for extant results (the old news hypothesis). We subsequently received two critical responses. Burr, Anobile, and Arrighi rejected our critiques wholesale, arguing that the evidence for number adaptation remains overwhelming. Durgin questioned (...) our old news hypothesis — preferring instead a theory about density adaptation he has championed for decades — but also highlighted several ways in which our arguments do pose serious challenges for proponents of number adaptation. Here, we reply to both. We first clarify our position regarding number adaptation. Then, we respond to our critics’ concerns, highlighting seven reasons why we remain skeptical about number adaptation. We conclude with some thoughts about where the debate may head from here. (shrink)

Scheinerman (2023) proposes a Citizen’s Jury on human germline genome editing (HGGE) to promote more inclusive public engagement, agenda setting and governance. She argues these juries should work...

In this article we argue that sustainable development is not a socio-ecologically friendly principle. The principle, which is deeply embedded in environmental law, policymaking and governance, drives environmentally destructive neoliberal economic growth that exploits and degrades the vulnerable living order. Despite seemingly well-meaning intentions behind the emergence of sustainable development, it almost invariably facilitates exploitative economic development activities that exacerbate systemic inequalities and injustices without noticeably protecting all life forms in the Anthropocene. We conclude the article by examining an attempt (...) to construct alternatives to sustainable development through the indigenous onto-epistemology of buen vivir. While no panacea, buen vivir is a worldview that offers the potential to critically rethink how environmental law could re-orientate away from its ‘centered’, gendered and anthropocentric, neoliberal sustainable development ontology, to a radically different ontology that embraces ecologically sustainable ways of seeing, being, knowing and caring. (shrink)

In recent years, we have experienced rapid development of advanced technology, machine learning, and artificial intelligence (AI), intended to interact with and augment the abilities of humans in practically every area of life. With the rapid growth of new capabilities, such as those enabled by generative AI (e.g., ChatGPT), AI is increasingly at the center of human communication and collaboration, resulting in a growing recognition of the need to understand how humans and AI can integrate their inputs in collaborative teams. (...) However, there are many unanswered questions regarding how human–AI collective intelligence will emerge and what the barriers might be. Truly integrated collaboration between humans and intelligent agents may result in a different way of working that looks nothing like what we know now, and it is important to keep the essential goal of human societal well-being and prosperity a priority. In this special issue, we begin to scope out the underpinnings of a socio-cognitive architecture for Collective HUman-MAchine INtelligence (COHUMAIN), which is the study of the capability of an integrated human and machine (i.e., intelligent technology) system to achieve goals in a wide range of environments. This topic consists of nine papers including a description of the conceptual foundation for a socio-cognitive architecture for COHUMAIN, empirical tests of some aspects of this architecture, research on proposed representations of intelligent agents that can jointly interact with humans, empirical tests of human–human and human–machine interactions, and philosophical and ethical issues to consider as we develop these systems. (shrink)

Artificial Intelligence (AI) powered machines are increasingly mediating our work and many of our managerial, economic, and cultural interactions. While technology enhances individual capability in many ways, how do we know that the sociotechnical system as a whole, consisting of a complex web of hundreds of human–machine interactions, is exhibiting collective intelligence? Research on human–machine interactions has been conducted within different disciplinary silos, resulting in social science models that underestimate technology and vice versa. Bringing together these different perspectives and methods (...) at this juncture is critical. To truly advance our understanding of this important and quickly evolving area, we need vehicles to help research connect across disciplinary boundaries.This paper advocates for establishing an interdisciplinary research domain—Collective Human-Machine Intelligence (COHUMAIN). It outlines a research agenda for a holistic approach to designing and developing the dynamics of sociotechnical systems. In illustrating the kind of approach, we envision in this domain, we describe recent work on a sociocognitive architecture, the transactive systems model of collective intelligence, that articulates the critical processes underlying the emergence and maintenance of collective intelligence and extend it to human–AI systems. We connect this with synergistic work on a compatible cognitive architecture, instance-based learning theory and apply it to the design of AI agents that collaborate with humans. We present this work as a call to researchers working on related questions to not only engage with our proposal but also develop their own sociocognitive architectures and unlock the real potential of human–machine intelligence. (shrink)

Two important questions arise concerning the properties that constitute the phenomenal characters of our experiences: first, where these properties exist, and, second, whether they are tied to our consciousness of them. Such properties can either exist externally to the perceiving subject, or internally to her. This article argues that phenomenal characters, and specifically the phenomenal characters of colours, may exist independently of consciousness and that they are internal to the subject. We defend this combination of claims against a recent criticism (...) according to which the unconscious phenomenal character of colours exists externally to the subject. We defend internalism about (potentially unconscious) phenomenal character by appealing to recent neuroscientific and behavioural evidence, and by rejecting the claim that externalism about phenomenal character is dialectically in a better position than internalism. In addition, we briefly present certain difficulties for externalist views of phenomenal character. These concern cases where the perceptual relation fails, but a perceptual experience still results. These points suffice to defuse the externalist critique of our view, and support the internalist variant of the consciousness-independence claim as the most plausible account of the unconscious phenomenal character of colours. (shrink)

Is it possible for an individual that has gone out of being to come back into being again? The English Aristotelian, Thomas White, argued that it is not. Thomas Hobbes disagreed, and used the case of the Ship of Theseus to argue that individuals that have gone out of being may come back into being again. This paper provides the first systematic account of their arguments. It is doubtful that Hobbes has a consistent case against White. Still his criticism may (...) have prompted White to clarify his views on identity over time in his later work. (shrink)

This article argues that correctional institutions violate the Eighth Amendment when they refuse to establish MAT programs and prevent doctors from exercising medical judgment to properly treat incarcerated people with OUD.

Background: Randomized controlled trials have been criticized for their inability to identify and differentiate the causal mechanisms that generate the outcomes they measure. One solution is the development of realist trials that combine the empirical precision of trials' outcome data with realism's theoretical capacity to identify the powers that generate outcomes. Main Body: We review arguments for and against this position and conclude that critical realist trials are viable. Using the example of an evaluation of the educational effectiveness of virtual (...) reality simulation, we explore whether Partial Least Squares Structural Equation Modelling can move statistical analysis beyond correlational analysis to support realist identification of the mechanisms that generate correlations. Conclusion: We tentatively conclude that PLS-SEM, with its ability to identify ‘points of action’, has the potential to provide direction for researchers and practitioners in terms of how, for whom, when, where and in what circumstances an intervention has worked. (shrink)

Analyzes cinematic conventions of transparency, and offers an interpretation of Fight Club.

This article is currently available as a free download on ingentaconnect.

In this enlightening book, Sam Harris argues that free will is an illusion but that this truth should not undermine morality or diminish the importance of social and political freedom; indeed, this truth can and should change the way we think about some of the most important questions in life.

In Virtual Worlds, Benjamin Woolley examines the reality of virtual reality.

Much bioethical literature and policy guidances for big data analytics in biomedical research emphasize the importance of trust. It is essential that potential participants trust so they will allow their data to be used to further research. However, comparatively, little guidance is offered as to what trustworthy oversight mechanisms are, or how policy should support them, as data are collected, shared, and used. Generally, “trust” is not characterized well enough, or meaningfully enough, for the term to be systematically applied in (...) policy development. Yet points made in the philosophical literature on trust can help. They allow us, not only to better distinguish the different ways the term “trust” may be interpreted, but also to better determine how different approaches to trust can align with policy and governance—in what ways they may relate to key bioethical concepts and related laws, and in what ways they can help to balance individual and group interests in data sharing. This article draws from the philosophical literature on trust to identify a relationship among consent, trust, and justice. Specifically, parallels are drawn between “character-trustworthiness” and “natural justice,” a set of widely held legal safeguards intended to ensure decision-makers follow a pattern of procedural fairness which protects the rights of the individual and thereby maintains public confidence in the decision-making process. Relevance to traditional bioethical principles, established laws, and consent procedures are addressed throughout. In conclusion, policy actions are suggested. (shrink)

A comment on “Editorial 37” Content Type Journal Article Pages 93-95 DOI 10.1007/s10698-011-9110-4 Authors Brian T. Sutcliffe, Laboratoire de Chimie quantique et Photophysique, Université Libre de Bruxelles, B-1050 Bruxelles, Belgium R. Guy Woolley, School of Biomedical and Natural Sciences, Nottingham Trent University, Nottingham, NG11 8NS UK Journal Foundations of Chemistry Online ISSN 1572-8463 Print ISSN 1386-4238 Journal Volume Volume 13 Journal Issue Volume 13, Number 2.

In his philosophy of ethics and time, Emmanuel Levinas highlighted the tension that exists between the "ontological adventure" of immediate experience and the "ethical adventure" of redemptive relationships-associations in which absolute responsibility engenders a transcendence of being and self. In an original commingling of philosophy and cinema study, Sam B. Girgus applies Levinas's ethics to a variety of international films. His efforts point to a transnational pattern he terms the "cinema of redemption" that portrays the struggle to connect to others (...) in redeeming ways. Girgus not only reveals the power of these films to articulate the crisis between ontological identity and ethical subjectivity. He also locates time and ethics within the structure and content of film itself. Drawing on the work of Luce Irigaray, Tina Chanter, Kelly Oliver, and Ewa Ziarek, Girgus reconsiders Levinas and his relationship to film, engaging with a feminist focus on the sexualized female body. Girgus offers fresh readings of films from several decades and cultures, including Frank Capra's _Mr. Smith Goes to Washington_ (1939), Federico Fellini's _La dolce vita_ (1959), Michelangelo Antonioni's _L'avventura_ (1960), John Huston's _The Misfits_ (1961), and Philip Kaufman's _The Unbearable Lightness of Being_ (1988). (shrink)

Time is woven into the fabric of our lives. Everything we do, we do in and across time. It is not just that our lives are stretched out in time, from the moment of birth to the moment of our death. It is that our lives are stories. We make sense of ourselves, today, by understanding who we were yesterday, and the day before, and the day before that; by understanding what we did and why we did it. Our memories (...) shape our present selves, since we are the product of who we were, and who we remember being. Yet who we are lasts for but a moment. It is who we will be that demands attention. We are forever projecting ourselves into the future. We painstakingly plan for the needs of our future selves, all the while knowing that while what we do will make those future selves who they are, still, our future selves are elusive. So it is not simply that we happen to live our lives in time, the way, say, one might happen to live in Australia, or Singapore. It is hard to fathom how things could be otherwise. What would it be to live a life without time? Yet time itself is intangible. Though we are keenly aware of what has been ‒ of pain and loss, regret and pride ‒ and of what might be ‒ of anticipation, and dread, and longing ‒ time itself seems unaffected by anything we do. Though we can anticipate a future birthday cake, time itself cannot be tasted. Though we can dread a future dentist’s appointment, time itself cannot be touched. Though we remember the crunching of leaves this past autumn, time itself cannot be heard. How can it be that something so central to each of us, to who we are, and what we care about, can be so spectral? What, in the end, is time? Is time real, like a substance in which each of us, like insects in amber, finds ourselves trapped? Is time a dimension through which we can move? Is time not a thing at all, but some connection between events? If time is real, what is it like? Does it flow like a river, taking each of us prisoner in its current, washing us ever closer to the end of our lives? Is time like a cresting wave, coming ever closer to each of us from the future, engulfing us, and then receding into the past? Or is time static? Like a one-way road that each of us might wander, with no chance to turn back? Or perhaps time is like none of these things. Perhaps time is more like space; something we can navigate freely, so that we can visit different times just like we visit different places. Perhaps we can we travel in time the way we can travel in space. These questions, and many more, are the focus of this book. Now, you might wonder what philosophers are doing writing a book about time. Surely that’s a job for physicists! It is true: a great deal of what we know about time stems from our understanding of physics. However, even in physics we find that there are questions about time that go unanswered. Moreover, increasingly, physicists are turning to philosophers for help in understanding the role that time plays in current physical theories. Our goal is to get the reader up to speed on some of the central issues that influence our understanding of time so that they too may play a role in this ongoing discussion between science and philosophy. We hope that in doing so it will become clear what philosophy can bring to the study of time. There is a natural narrative in philosophy regarding the study of time, and we have chosen to organise this book according to that narrative. However, the book may also be approached in a ‘choose-your-own adventure’ spirit. While later chapters build on material introduced in earlier chapters, you can skip around, reading the book in any order you choose. For the instructor, this means that she can design her course around this book in any number of ways, depending on the particular topic she wishes to focus on. (shrink)

This article is currently available as a free download on ingentaconnect.

Gordon Kaufman's “constructive theology” can easily be taken out of context and misunderstood or misrepresented as a denial of God. It is too easily overlooked that in his approach everything is an imaginary construct given no immediate ontological status—the self, the world, and God are “products of the imagination.” This reflects an influence, not only of theories on linguistic and cultural relativism, but also of Kant's “ideas of pure reason.” Kaufman is explicit about this debt to Kant. But I argue (...) there are other aspects of Kant's legacy implicit in his method. These center around Kaufman's engagement with “observed patterns” in nature. With Paul Tillich's aid, I bring this neglected issue to the fore and argue that addressing it allows one to more readily capitalize upon the Kantian influence in Kaufman's method. This, in turn, encourages one to tap more deeply into the epistemic underpinnings of Kaufman's approach to the science–religion dialogue. (shrink)

The idea of forgiveness is omnipresent in the transitional justice literature, yet this body of work, taken as a whole, is marked by conceptual, terminological and argumentative imprecision. Equivocation is common, glossing moral, theological, therapeutic and legal considerations, while arguments proceed from political, apolitical and even antipolitical premises. With forgiveness as a praxis linked to reconciliation processes in at least ten countries, concerns have grown over its negative implications for the relationship between the state and victims of state-authored injustices. Many (...) of these debates reference Hannah Arendt. Drawing from a range of Arendt’s published and unpublished work, this article challenges the academic claim that forgiveness has no place in the politics of reconciliation. Through this ‘returning to the source’, it presents a promising mode of thinking about political forgiveness in contemporary Settler-colonial states. (shrink)

In Time, Existential Presence and the Cinematic Image, Sam B. Girgus relates Laura Mulvey's theory of 'delayed cinema' to ideas on time and the relationship to the other in the writings of Jean-Luc Nancy, Emmanuel Levinas and Julia Kristeva, among others. The sustained tension in film between, in Mulvey's phrase, 'stillness and the moving image' enacts a drama of existential emergence. The stillness of the framed image in relation to the moving image opens 'free' cinematic time and space for a (...) fresh engagement with crucial ethical and cultural issues. With close readings of films such as The Bicycle Thieves, Two Days, One Night, The Three Burials of Melquiades Estrada, The Revenant and The Age of Innocence, this book proposes a fresh approach to reading film in the context of emerging existential presence and the ethical imperative. (shrink)

SAM GREY | : Prevailing connotations of reconciliation orbit concord or harmonious coexistence, meaning that concern for justice is necessarily subordinated to a more casually pragmatic peace. Bringing justice considerations to the fore means focusing on reparations as a key element of reconciliation’s suite of activities—but reparations are necessarily a matter of process, which precludes considering elements of the “package” in isolation from one another, as is the case with traditional evaluative criteria of motivation or proportion. Accordingly, this article proposes (...) that reparations are better framed as a considered reaction to the unjust allocation of burdens, so that subsequent reallocations serve justice by answering the needs and demands of survivors. Taking cues from a variety of sources both within and beyond the transitional justice literature, the work at hand attempts just such a retrospective reframing by looking at a recently completed Canadian reparations process: the Indian Residential Schools Settlement Agreement. | : Les connotations dominantes de la réconciliation gravitent autour de la concorde ou de la coexistence harmonieuse, signifiant que le souci de la justice est nécessairement subordonné à une paix plus pragmatique. Mettre les considérations de justice au premier plan implique de mettre l’accent sur les réparations comme un élément clé de la série d’activités de la réconciliation, mais les réparations sont nécessairement une question de processus, ce qui exclut de considérer ses éléments isolément, comme c’est le cas des critères évaluatifs traditionnels de motivation ou de proportion. En conséquence, cet article propose que les réparations sont mieux conçues comme une réaction réfléchie à l’attribution injuste des charges, de sorte que les réallocations ultérieures servent la justice en répondant aux besoins et aux exigences des survivants. S’inspirant d’une variété de sources à l’intérieur et à l’extérieur de la littérature sur la justice transitionnelle, le présent travail tente un tel recadrage rétrospectif en examinant un processus canadien de réparations récemment terminé : la Convention de règlement relative aux pensionnats indiens. (shrink)

Although parliamentary government is generally taken to be party government and party cohesion is acknowledged a key element thereof, it seems an accepted part of comparative parliamentary research that the effectiveness of parliaments and the level ofparty cohesion are negatively related. This is in part a remnant of the Anglo-American comparative studies that have dominated the discipline for a long time. Within reactive parliaments, this negative relation fails to materialise. Combining results from earlier research and original data, it is demonstrated (...) that a high level ofparty cohesion does not prevent parliaments to be an effective, independent player in government formation, the recruitment of cabinet ministers or policy making. Comparing ten European parliaments, the more effective parliaments do encompass parliamentary parties with the highest level ofcohesion. A more crucial element isperhaps the characteristic of parliamentary parties as essentially oriented to the extra-parliamentary party or as a dominant element in the party-as-a-whole. Further research is however necessary. (shrink)

Inquiry aims at knowledge. Your inquiry into a question succeeds just in case you come to know the answer. However, combined with a common picture on which misleading evidence can lead knowledge to be lost, this view threatens to recommend a novel form of dogmatism. At least in some cases, individuals who know the answer to a question appear required to avoid evidence bearing on it. In this paper, we’ll aim to do two things. First, we’ll present an argument for (...) this novel form of dogmatism and show that it presents a substantive challenge. Second, we’ll consider a way those who take knowledge to be the aim of inquiry can mount a response. In the course of doing so, we’ll try to get clearer on the normative connections between inquiry, knowledge and evidence gathering. (shrink)

As the recent inaugural Ethical, Legal, and Social Issues 2.0 conference made clear, the effects of information communication technology are pervasive in biomedical research. Data initiatives are arising in all corners of biomedicine. Data sharing efforts already promised to surpass even the ambitious goals of the National Human Genome Research Institute, only 5 years after publication of its 10-year vision. ELSI research was established, in part, to address challenges of open data access and data sharing. However, by and large, ELSI (...) research projects address particular concerns of a given population, jurisdiction, type of research practice or type of data. This does not necessarily facilitate coherent data policy for sustainable data stewardship. Forward-looking, data friendly strategies need to be considered. Orchestration strategies are needed which overcome barriers to collective action. Here we present challenges policymakers face, and suggest three basics steps towards meeting them. First, policymakers must recognise the systematic change that occurs when ICT enables dataflow itself to become an organising principle of biomedical research. Second, methods for identifying and gathering types of metadata suitable for ELSI research ought to be developed and regulated. Third, policymakers need to organise in ways that mirror the new vision for data-enabled research that data technologies are making possible, as ELSI 2.0 encourages researchers to do. Taking these steps will help ensure research evolves in ways that warrants trust of the public while still supporting widespread ethical access to necessary data, research subjects, samples and findings. (shrink)

Organizations are increasingly looking for ways to reap the benefits of cognitive diversity for problem solving. A major unanswered question concerns the implications of cognitive diversity for longer-term outcomes such as team learning, with its broader effects on organizational learning and productivity. We study how cognitive style diversity in teams—or diversity in the way that team members encode, organize and process information—indirectly influences team learning through collective intelligence, or the general ability of a team to work together across a wide (...) array of tasks. Synthesizing several perspectives, we predict and find that cognitive style diversity has a curvilinear—inverted U-shaped—relationship with collective intelligence. Collective intelligence is further positively related to the rate at which teams learn, and is a mechanism guiding the indirect relationship between cognitive style diversity and team learning. We test the predictions in 98 teams using ten rounds of the minimum-effort tacit coordination game. Overall, this research advances our understanding of the implications of cognitive diversity for organizations and why some teams demonstrate high levels of team learning in dynamic situations while others do not. (shrink)

Sam Gillespie's The Mathematics of Novelty presents a new account of Alain Badiou and Gilles Deleuze, identifying conceptual impasses in their philosophical ...

Sam Harris dismantles the most common justification for religious faith--that a moral system cannot be based on science.

Standard approaches to counterfactuals in the philosophy of explanation are geared toward causal explanation. We show how to extend the counterfactual theory of explanation to non-causal cases, involving extra-mathematical explanation: the explanation of physical facts by mathematical facts. Using a structural equation framework, we model impossible perturbations to mathematics and the resulting differences made to physical explananda in two important cases of extra-mathematical explanation. We address some objections to our approach.