Models of gene regulatory networks have proven useful for understanding many aspects of the highly complex behavior of biological control networks. Randomly generated non-Boolean networks were used in experimental simulations to generate data on dynamic phenotypes as a function of several genotypic parameters. We found that predictive relationships between some phenotypes and quantitative genotypic parameters such as number of network genes, interaction density, and initial condition could be derived depending on the strength of the topological genotype on specific phenotypes. We (...) quantitated the strength of the topological genotype effect on a number of phenotypes in multi-gene networks. For phenotypes with a low influence of topological genotype, derived and empirical relationships using quantitative genotype parameters were accurate in phenotypic outcomes. We found a number of dynamic network properties, including oscillation behaviors, that were largely dependent on genotype topology, and for which no such general quantitative relationships were determinable. It remains to be determined if these results are applicable to biological gene regulatory networks. (shrink)

A methodology is proposed as a tool for explanation of form in zoomorphology, in particular its design, diversity, and transformation. An alternate use of descriptive, inductive/comparative, and deductive methods is suggested. The basic concepts required are summarized. Following an extensive anatomical analysis a specific deductive methodology is developed, comprising three major parts: 1) Formal analysis of systems, using optimal design. 2) Transformation of an initial system's model by simulating modifications via maximizing the model for specific functional requirements. 3) Testing by (...) comparison of deduced modifications with real systems having the maximized functional capacity, trends in specific morphoclines, and empirical analogues from technology.The methodology produces a morpho-space of modifications that has the form of branching pathways. That pattern results from innovation, bifurcation, and radiation moments in the deduction. The morpho-space is converted in a mechano-space by including next to constructional characters those of operation and rolefulfilment. If the initial system is verified as the ancestor and the transformation-function is verified as the evolutionary theme of change, the explanation turns -in addition to a function anatomical one- also into an evolutionary one. The method is illustrated by reviewing some recent analyses about avian feeding: maximization of avian pecking for probing and filter feeding capacities. (shrink)

1) vgl.,,50phistes" 248c4 - 253c3 und 254b7-257aI2. 2) Heidegger, Brief über den "Humanismus"; s. in "Platons Lehre von der Wahrheit", Bern 1947,5.53. 3) 5. Diels "Fragmente der Vorsokratiker"6, Berlin 1951; Parmenides B l. 4) Reinhardt "Parmenides und die Geschichte der griechischen Philosophie", Bonn 1916, 5.32 ff.; zu dem Verhältnis der beiden "Teile" des Gedichts ist u.a. zu vergleichen: Fränkel "Parmenidesstudien" (Götting. Nachr. 1930, 5.153 ff.), Abschnitt IV und V; Calogero, 5tudi sull' Eleatismo, Rom 1932; Riezler "Par­ menides", Frankfurt 1934 (dazu (...) die Rezension von Gadamer in "Gnomon" XII 1936,5.77 ff.); Jaeger "Die Theologie der frühen griechischen Denker", 5tutt­ gart 1953,5.123 f.. 5) B 8,1 '"!J.6~o~ i3't;,~ t-'"ü'&?~ o~?,Io AeL7tE'Tct,L w~, e,O'''n~.. ~., 6) B 8,2... "t"lXu··nJI Il zm. (shrink)

C.H. Waddington is today remembered chiefly as a Drosophila developmental geneticist who developed the concepts of “canalization” and “the epigenetic landscape.” In his lifetime, however, he was widely perceived primarily as a critic of Neo-Darwinian evolutionary theory. His criticisms of Neo-Darwinian evolutionary theory were focused on what he saw as unrealistic, “atomistic” models of both gene selection and trait evolution. In particular, he felt that the Neo-Darwinians badly neglected the phenomenon of extensive gene interactions and that the “randomness” of mutational (...) effects, posited in the theory, was a false postulate. This last criticism dealt with the phenomenon known today as “developmental constraints.” Although population genetics itself has evolved considerably from its form at mid-20th century, much of Waddington’s critique, it is argued here, retains cogency. Yet, he did not attempt to develop a full-fledged alternative theory himself. Perhaps most surprisingly, in retrospect, is that he did not try to marry his work on gene interactions in development with his evolutionary interests, to create a theory of “genetic networks” and their evolution. Whether evolutionary genetics today will incorporate “network thinking” as a central element or whether there will be a general retreat to the more atomistic approach offered by genomics, remains an open question. (shrink)

On the life and works of Maṇḍanamiśra, philosopher of Saṅkarācārya tradition.

ch. 1. Istorii︠a︡ sot︠s︡iologicheskikh ucheniĭ -- ch. 2. Nauchnai︠a︡ teorii︠a︡ obshchestva.

The history of the Russian Old Believers who lived in Ukraine, as well as the question of the main methods and features of the power struggle with representatives of this peculiar ethno-confessional group and the ways of their adaptation to the conditions that existed in the Russian Empire in the middle of the XIX century remain a little researched topic. So, we can talk about the scientific relevance of a particular problem.

A version of nonstandard analysis, Internal Set Theory, has been used to provide a resolution of Zeno's paradoxes of motion. This resolution is inadequate because the application of Internal Set Theory to the paradoxes requires a model of the world that is not in accordance with either experience or intuition. A model of standard mathematics in which the ordinary real numbers are defined in terms of rational intervals does provide a formalism for understanding the paradoxes. This model suggests that in (...) discussing motion, only intervals, rather than instants, of time are meaningful. The approach presented here reconciles resolutions of the paradoxes based on considering a finite number of acts with those based on analysis of the full infinite set Zeno seems to require. The paper concludes with a brief discussion of the classical and quantum mechanics of performing an infinite number of acts in a finite time. (shrink)

Several recent papers dealing with Plato's position on the imperfection of the phenomenal world draw heavily on the differences between two kinds of predicates in order to show the following: In the middle dialogues, Plato posits Forms only as referents of what the writers call incomplete predicates. He does not posit Forms as referents for complete predicates. When interpreters ignore the differences between these kinds of predicates, they ascribe too radical a view regarding the imperfection of the phenomenal world to (...) the middle dialogues. The ontology of these dialogues includes sensible particulars which retain their identity over time even though they are continually changing in some respect or other. (shrink)

Confidence ratings have often been integrated into reasoning and intelligence tasks as a means for assessing meta-reasoning processes. Although it is often assumed that eliciting these judgements throughout reasoning tasks has no effect on the underlying performance outcomes, this is yet to be established empirically. The current study examines whether eliciting CR from participants during a fluid-reasoning task influences their performance and how this effect is moderated by their initial self-confidence in their own reasoning abilities. In a first experiment, we (...) found that participants performing CR during Raven's Progressive Matrices significantly outperformed a control group who did not provide ratings. Additionally, a second experiment demonstrated that CR only facilitated performance in participants who have a high level of initial self-confidence in their reasoning ability, whereas they were detrimental to participants low in self-confidence. (shrink)

in a recent article entitled “Hume on the Passions,” Stephen Buckle opens with the claim that Hume’s theory of the passions has largely been neglected. “Apart from a couple of famous sections in the Treatise concerning the sources of action,” he writes, “the subject matter has rarely excited interest.”1 His analysis of why the subject of the passions in Hume has been uninspiring points to the fact that readers have largely misunderstood the point of Hume’s theory. They usually regard the (...) account as yet another mechanistic analysis of the passions in the vein of seventeenth-century science, alongside the offerings of Malebranche, Hobbes, and Spinoza. Buckle is right to point out that there is a.. (shrink)

: Dr. Smith is an internist in private practice who works at an inner city clinic affiliated with a university hospital. He is also a member of the university faculty. Many of Dr. Smith’s patients have type 2 diabetes mellitus and struggle with health care and other costs. Thinking about opportunities to better serve his patients and advance his career, Dr. Smith considers conducting clinical research in his office. ACME is a respected pharmaceutical company that for decades has engaged in (...) research, development, and production of widely used drugs. Several of ACME’s oral agents for type 2 diabetes will soon go off patent. In an effort to retain its market share in this class of drugs, ACME wants to complete clinical trials expeditiously and obtain approval for its new oral hypoglycemic medicine. The company approaches Dr. Smith to be a coinvestigator in its multicenter clinical trial. (shrink)

Ayn Rand's first novel, We the Living, offers an early form of the author's nascent philosophy—the philosophy Rand later called Objectivism. Robert Mayhew's collection of entirely new essays brings together pre-eminent scholars of Rand's writing. In part a history of We the Living, from its earliest drafts to the Italian film later based upon it, Mayhew's collection goes on to explore the enduring significance of Rand's first novel as a work both of philosophy and of literature.

Aim To study the views on the acceptability of physician-assisted-suicide of lay people and health professionals in an African country, Togo.Method In February–June 2012, 312 lay people and 198 health professionals in Togo judged the acceptability of PAS in 36 concrete scenarios composed of all combinations of four factors: the patient's age, the level of incurability of the illness, the type of suffering and the patient's request for PAS. In all scenarios, the patients were women receiving the best possible care. (...) The ratings were subjected to cluster analysis and analyses of variance.Results Most lay people were not systematically opposed to PAS, whereas most health professionals were systematically opposed to it. The most important factors in increasing acceptability among people not systematically opposed were advanced age of the patient and incurability of the illness. Additional acceptability was provided by the patient's request to have her life ended, although much less so than in studies in Western countries, and by suffering characterised by complete dependence rather than by extreme physical pain.Conclusions These empirical findings—the first ones gathered in the African continent—suggest that most Togolese lay people are not categorically for or against PAS, but judge its degree of acceptability as a function of concrete circumstances. (shrink)

In classes that examine entrenched injustices like sexism or racism, students sometimes use “distancing strategies” to dissociate themselves from the injustice being studied. Education researchers argue that distancing is a mechanism through which students, especially students of apparent privilege, deny their complicity in systemic injustice. While I am sympathetic to this analysis, I argue that there is much at stake in student distancing that the current literature fails to recognize. On my view, distancing perpetuates socially sanctioned forms of ignorance and (...) unknowing, through which students misrecognize not only their complicity in injustice, but also the ways that injustice shapes the world, their lives, and their knowledge. Thus, distancing is pedagogically problematic because it prevents students from understanding important social facts, and because it prevents them from engaging with perspectives, analyses, and testimonies that might beneficially challenge their settled views and epistemic habits. To substantiate this new analysis, I draw on recent work on epistemologies of ignorance, especially José Medina’s account of “active ignorance.” In order to respond to student distancing, I argue, it is not sufficient for teachers to make students aware of injustice, or of their potential complicity in it. Beyond this, teachers should cultivate epistemic virtue in the classroom and encourage students to take responsibility for better ways of knowing. The article ends by outlining several classroom practices for beginning this work. (shrink)

Mistaken judgments of fact by sporting officials – blown calls – are ubiquitous in sport and have altered the outcomes of games, championships, and even the record books. I argue that the effect these blown calls have on sports is deplorable, even unjust, and that given both the nature of sport in general and the social and economic importance of sports as they are played today, we ought to use technology to aid officials in making their judgments whenever doing so (...) would prove more effective than relying on unaided human perception. I then briefly address a number of objections to the increased use of technology in officiating. (shrink)