Recently it has become clear that integrins and other adhesive receptors play an important role in the control of cell growth and differentiation. In various cell types, anchorage to the extracellular matrix via integrins strongly influences the ability of the cell to respond to soluble mitogens or to differentiation factors. Thus adhesive receptors must generate signals that influence cell behavior. Some of the pathways of adhesion receptor signaling are now beginning to be worked out, but there is still much to (...) learn. In particular, the mechanistic basis for the cooperation between anchorage signals and signals from soluble growth and differentiation factors remains ill‐defined. This review will examine some of the current information linking adhesion receptors to control of mitogenesis and differentiation. (shrink)

In Infinity and the Mind, Rudy Rucker leads an excursion to that stretch of the universe he calls the "Mindscape," where he explores infinity in all its forms: potential and actual, mathematical and physical, theological and mundane. Here Rucker acquaints us with Gödel's rotating universe, in which it is theoretically possible to travel into the past, and explains an interpretation of quantum mechanics in which billions of parallel worlds are produced every microsecond. It is in the realm of infinity, (...) he maintains, that mathematics, science, and logic merge with the fantastic. By closely examining the paradoxes that arise from this merging, we can learn a great deal about the human mind, its powers, and its limitations. Using cartoons, puzzles, and quotations to enliven his text, Rucker guides us through such topics as the paradoxes of set theory, the possibilities of physical infinities, and the results of Gödel's incompleteness theorems. His personal encounters with Gödel the mathematician and philosopher provide a rare glimpse at genius and reveal what very few mathematicians have dared to admit: the transcendent implications of Platonic realism. (shrink)

In public communication contexts, such as when a company announces the proposal for an important organizational change, argumentation typically involves multiple audiences, rather than a single and homogenous group, let alone an individual interlocutor. In such cases, an exhaustive and precise characterization of the audience structure is crucial both for the arguer, who needs to design an effective argumentative strategy, and for the external analyst, who aims at reconstructing such a strategic discourse. While the peculiar relevance of multiple audience is (...) often emphasized in the argumentation literature and in rhetorical studies, proposals for modelling multi-audience argumentative situations remain scarce and unsystematic. To address this gap, we propose an analytical framework which integrates three conceptual constructs: Rigotti and Rocci’s notion of communicative activity type, understood as the implementation of an interaction scheme into a piece of institutional reality, named interaction field; the stakeholder concept, originally developed in strategic management and public relations studies to refer to any actor who affects and/or is affected by the organizational actions and who, accordingly, carries an interest in them; the concept of participant role as it emerges from Goffman’s theory of conversation analysis and related linguistic and media studies. From this integration, we derive the notion of text stakeholder for referring to any organizational actor whose interest becomes an argumentative issue which the organizational text must account for in order to effectively achieve its communicative aim. The text stakeholder notion enables a more comprehensive reconstruction and characterization of multiple audience by eliciting the relevant participants staged in a text and identifying, for each of them, the interactional role they have, the peculiar interest they bear and the related argumentative issue they create. Considering as an illustrative case the defense document issued by a corporation against a hostile takeover attempt made by another corporation, we show how this framework can support the analysis of strategic maneuvering by better defining the audience demand and, so, better explaining how real arguers design and adapt their topical and presentational choices. (shrink)

In spite of successful tests, the standard cosmological model, the $$\varLambda$$ CDM model, possesses the most problematic concept: the initial singularity, also known as the big bang. In this paper—by adopting the Kantian difference between to think of an object and to cognize an object—it is proposed a degree of scientificity using fuzzy sets. Thus, the notion of initial singularity will not be conceived of as a scientific issue because it does not belong to the fuzzy set of what is (...) known. Indeed, the problematic concept of singularity is some sort of what Kant called the noumenon, but science, on the other hand, is constructed in the phenomenon. By applying the fuzzy degree of scientificity in cosmological models, one concludes that cosmologies with a contraction phase before the current expansion phase are potentially more scientific than the standard model. At the end of this article, it is shown that Kant’s first antinomy of pure reason indicates a limit to our cosmological models. (shrink)

Rudi Visker's book is not only a lucid and elegant survey of Foucault's corpus, from his early work on madness to the History of Sexuality, but also a major intervention in this debate.

What does it mean to drive a Cadillac? What does 'cuckoo' suggest about the bird? -- two examples explored in this investigation of the history of language signs and of what philosophers, linguists, and others have had to say about them. Rudi Keller shows how signs emerge, function, and develop in the permanent process of language change. He recombines thoughts and ideas from Plato to the present day to create a new theory of the meaning and evolution of icons and (...) symbols. By assuming no prior knowledge and by developing his argument from first principles, Rudi Keller has written a basic text which includes all the necessary features: easy style, good organization, original scholarship, and historical depth. This is a non-technical book which will interest linguists, philosophers, students of communications and cultural studies, semioticians/semanticists, sociologists, and anthropologists. (shrink)

L’un des philosophes les plus importants de l’histoire, Friedrich Nietzsche, est presque ignoré par les physiciens. L’auteur qui a déclaré la mort de Dieu au xixe siècle était enthousiasmé par la science, principalement durant la deuxième partie de son œuvre. À l’aide de la notion physique de force, Nietzsche a créé son concept de volonté de puissance. En pensant à la conservation de l’énergie, le philosophe allemand a eu une certaine inspiration pour créer son concept de l’éternel retour. Dans cet (...) article, on souligne certaines influences de la physique sur Nietzsche et on discute de l’actualité de sa position épistémologique—le perspectivisme. À partir du concept de volonté de puissance, je propose que le perspectivisme conduise à l’interprétation où la physique et la science en général sont considérées comme un jeu. (shrink)

Introduction: Talking 'bout my generation -- Part I: Looking for difference -- Levinas, multiculturalism, and us -- In respectful contempt : Heidegger, appropriation, facticity -- Whistling in the dark : two approaches to anxiety -- Part II: After Levinas -- The price of being dispossessed : Levinas' God and Freud's trauma -- The mortality of the transcendent : Levinas and evil -- Is ethics fundamental? : questioning Levinas on irresponsibility -- Part III: After Heidegger -- Intransitive facticity : a question (...) to Heidegger -- Demons and the demonic : Kierkegaard and Heidegger on anxiety and sexual difference -- Dissensus communis : how to keep silent "after" Lyotard -- Conclusion: In search of visibility. (shrink)

An encyclopedia article on the epistemic or knowledge condition for moral responsibility, written for the SEP.

It is shown that a notion of natural place is possible within modern physics. For Aristotle, the elements—the primary components of the world—follow to their natural places in the absence of forces. On the other hand, in general relativity, the so-called Carter–Penrose diagrams offer a notion of end for objects along the geodesics. Then, the notion of natural place in Aristotelian physics has an analog in the notion of conformal infinities in general relativity.

O artigo lança um olhar sobre as deficiências físicas, sensoriais e cognitivas da pessoa humana, substituindo a ideia de Deus como seu causador direto ou indireto pela teoria da aleatoriedade. Define a deficiência como expressão do caráter limitado do ser humano em geral. Propõe uma abordagem pastoral e uma postura ética diante das pessoas com deficiência.

Stress-induced brain-mediated immunoregulation is effected by two pathways: autonomic outflow and (neuro)endocrine outflow. Particular attention is given to the interaction-effects of chronic an acute stress. Recent data have established that cells of the immune system produce neuro-peptides and hormones. In concert with cytokines released by these immune cells the brain can be informed on the nature of ongoing immune activity. The significance of conditioning of immune responses is discussed.

O presente artigo investiga a unidade de valor entre ética e moral, proposta por Ronald Dworkin, assumindo, como ponto de partida, o constitucionalismo pluralista latino-americano. Para tanto, o bem viver, afirmado pelas Constituições boliviana e equatoriana mediante o resgate da sabedoria indígena ancestral – pelo reconhecimento respectivamente do suma qamaña e do sumak kawsay como fundamentos da ordem constitucional – é problematizado a partir da relação que possui com o desafio de consolidação de uma vida boa que expresse o comprometimento (...) com os valores de liberdade, igualdade e comunidade. Referido objeto demandou abordagem interdisciplinar, com destaque para a interação entre o Direito Constitucional e a Filosofia. Os resultados da investigação apontam para a convergência entre a concepção de vida boa aludida por Dworkin e o bem viver que fundamenta as constituições pluralistas latino-americanas. A pesquisa se insere na vertente jurídico-sociológica para o desenvolvimento de investigação de tipo jurídico-investigativo e técnica bibliográfica. Para consideração das fontes, foi adotado o procedimento de análise de conteúdo, com a predominância de raciocínios dedutivos e dialéticos. (shrink)

This article builds upon earlier research in which the authors presented case studies focused on the design and development of two original ethical learning video games. Through this case study and a review of relevant literature, the authors explored the content creation of, and theoretical rationale for, the design and development of ethics games. Both games were geared toward an undergraduate student audience as casual learning games to be completed in a few hours of gameplay. To update and expand this (...) original work, the authors reviewed contemporary research on identity, cognition, and self in relation to video game environments as well as literature dealing more specifically with ethics and video games. From this literature base and their applied design experiences, the authors offer ten guidelines as best practices to follow for aspiring ethics game developers. (shrink)

The interactive nature of the Internet is seen by some as a technological innovation that might boost participation in politics and civic affairs. That potential, however, is clouded by imprecise definitions of interactivity found among scholars and practitioners alike. Evaluation of state legislature Web sites found them to not be very interactive under most definitions of the term. Chief technology officers of the legislatures appear to differ as to which site features promote interactivity. The current state of these sites may (...) do more to encourage civic engagement than to promote interactivity. (shrink)

Abstract:This essay establishes a cross-cultural comparison between Kierkegaard's ironist and the figure of the Chan master, with specific reference to Kierkegaard's dissertation The Concept of Irony and the renowned gongan collection Blue Cliff Record (Biyan lu 碧巖錄). The main thesis is that the comparison makes explicit significant aspects of Chan orthopraxis, since Chan masters, as presented in the Blue Cliff Record, exemplify Kierkegaard's portrayal of the ironist. In particular, these aspects pertain to the progressive detachment from the discriminating action of (...) karmic consciousness and self-centered thinking, toward the cultivation of a selfless stance. The first section focuses on Kierkegaard's ironist. The following sections analyze relevant gongan narratives from the Blue Cliff Record with the purpose of expounding on the relation between performative irony and the discriminating mind, playfulness, and selflessness. The final section considers the major incommensurable differences that mark the present cross-cultural dialogue. (shrink)

Web sites of the 50 state legislatures are evaluated on five criteria: content, usability, interactivity, transparency, and audience. An overall quality score for each site was computed. The evaluation revealed a wide range of quality in the sites, including that of features or aspects that could possibly foster citizen participation. The higher rated sites help define “best practices” in this regard and provide suggestions as to how other states' sites might make improvements and possibly increase participation.

This article proposes a more culturalist and variegated conception of the individual than that presented by individualization theorists. Inspired by the approach of the individual advocated by Émile Durkheim, Talcott Parsons and John Meyers, it first outlines the general script of the individual-as-actor that informs modern individualism as well as the generic characteristics that are routinely attributed to persons such as agency and free will. It subsequently reconstructs three predominant interpretations of this general script, i.e. utilitarian, moral and expressive individualism. (...) For each variant, the intellectual genesis and overall definition of the institutionalization in specific societal domains and the dominant articulations in social theory are briefly presented. With this threefold distinction, the aim is to synthesize the extensive literature on individualism and to show the sociological strengths of approaching subjectivity in terms of institutionalized scripts. (shrink)

Non una pacifica esplorazione ma un’avanscoperta bellicosa, in sardonica guerrilla con alcuni baluardi della tradizione filosofica occidentale: le leggi e il linguaggio della metafisica, la concezione stabile e unitaria dell'identità personale, il modello tragico della volontà, il pregiudizio antropocentrico e l’asservimento della natura al dominio della tecnica. Senza la pretesa di comporre un discorso esaustivo o sistematico, Capra recupera soprattutto Nietzsche e il Wittgenstein delle Ricerche Logiche in una (auto)critica comparativa, per mostrare in quali modi il pensiero correlativo delle filosofie (...) orientali possa integrare e talvolta superare le impasse del pensiero antitetico. (shrink)

Construo esta pesquisa para dar visibilidade ao corpo estranho como produtor de arte, cultura e conhecimentos, quando esse encontra sua casa, o “seu corpo”, na escola. Esta se desenvolve epistemologicamente em Arte-educação descolonial a partir da condição na qual sempre fui colocado, de corpo estranho, por ser imperfeito ao modelo de corpo colonial imposto no ocidente, sempre em relação a um Outro. Continuamente, por isso, vivo sendo posto na categoria de “Ser menos”, na cultura, na vida, no aprendizado, como outros (...) tantos corpos estranhos também vivem: ocupando o fundo da cena para deixar a coreografia em dança bonita ou as apresentações teatrais ou musicais harmônicas. (shrink)

The objective of this research is to interaction between perception in job characteristic model, psychological well - being, and performance. Job characteristic model are explained by skill variety, task identity, task significan, autonomy, and feedback about the job. Psychological well - being is explained by autonomy, environment mastery, good relationship with others, self acceptance, and personal growth. Performance measured by how employee done their task according their responsibility. Subject of this research are employees of PT. X. The result of this (...) study shows that all of the variables have positive interaction between each other.  . (shrink)

Graphical AbstractThis recent meeting covered non-bilaterian (e.g., cnidarians, ctenophores, and sponges) animals broadly, but with emphasis in four areas: 1) New genomic resources and tools for functional studies, 2) advances in developmental and regeneration studies, 3) the evolution and function of nervous systems, 4) symbiosis and the holobiome.

In his last papers about deontic logic, von Wright sustained that there is no genuine logic of norms. We argue in this paper that this striking statement by the father of deontic logic should not be understood as a death sentence to the subject. Rather, it indicates a profound change in von Wright's understanding about the epistemic and ontological role of logic in the field of norms. Instead of a logical constructivism of deontic systems revealing a necessary structure of prescriptive (...) discourse, which marked his earlier efforts, he adopted the view that such systems should be seem as mere objects of comparison, i.e. as providing practical standards of rationality for normgiving activity. Within such view he proposed an interpretation of standard deontic logic in such a way to free deontic logicians from the philosophical difficulties related to the so-called Jørgensen's dilemma and deontic paradoxes. This effort, as we claim in the present paper, is an application of Wittgenstein's therapeutic method to dissolve philosophical difficulties caused by the use of logical tools to model relations between norms. (shrink)

Nietzsche colocou-se como um antípoda a Platão. Mas em questões cosmológicas, o eterno retorno nietzschiano tem também alguns pontos em comum à cosmologia platônica descrita no Timeu. A finitude espacial, a ciclicidade cósmica e a ética cosmológica dizem respeito às semelhanças, já a infinitude temporal, a teleologia e a necessidade afastam os filósofos. Então, neste trabalho, aponto proximidades e afastamentos entre os dois filósofos em questões cosmológicas, além de sugerir alguma atualidade de suas concepções em relação à nossa ciência. Como (...) veremos, a relação entre ética e cosmologia ainda se mostra atual. (shrink)

Este artigo apresenta as questões essenciais da teoria crítica de Axel Honneth a partir do quadro referencial teórico hegeliano. Seria preciso, assim, o entendimento das questões fundamentais que Hegel enfrentava em seu tempo, para, então, contextualizar a proposta filosófica de Honneth. Sem o entendimento do quadro referencial teórico hegeliano, a reflexão da teoria crítica de Honneth torna-se incompleta. Apesar da reconhecida influência que Hegel tem na articulação teórica de Honneth, pouco se diz em que momentos específicos as questões postas por (...) Hegel também estão presentes no pensamento de Honneth. A nosso ver, isto é determinante para compreendermos o modelo crítico de Honneth. A partir de Hegel, destaca-se a categoria do reconhecimento que, em Honneth, aparece também como uma categoria central em sua proposta de teoria crítica. Primeiramente, debate-se o quadro referencial teórico hegeliano; em seguida, articula-se como as reflexões de Hegel também são essenciais para o entendimento da filosofia de Honneth. (shrink)

O artigo objetiva investigar, à luz do filósofo Charles Taylor, a questão do reconhecimento dos sujeitos a partir da relação entre secularismo e religião. O fio condutor do pensamento de Taylor é o comunitarismo. Este se relaciona com a ideia de que o contexto das normas que regem uma sociedade deve ser o de uma comunidade que, em seus valores, práticas e instituições formam um horizonte constitutivo para a identidade de seus membros. Somente assim seria possível colocar as questões da (...) justiça e, então, responder sobre o que é bom e o que deve valer para a comunidade. Segundo Taylor, os homens são seres expressivos porque pertencem a uma cultura que é nutrida e transmitida no interior de uma comunidade. Taylor parte da crítica hegeliana ao formalismo kantiano que deslocou o sujeito da comunidade, da história e da cultura, gerando demandas de reconhecimento. Ele enfatiza que a religião, por exemplo, ainda se relaciona com a formação das diversas identidades, tal qual uma esfera essencial na constituição dos sujeitos, mesmo em sociedades secularizadas. Taylor destaca a existência de múltiplas modernidades, uma vez que culturas não ocidentais foram modernizadas à sua maneira, sem a necessária separação entre identidades secularizadas e religiosas. O filósofo também defende uma redefinição do secularismo que valorize as religiões como fontes essenciais e indispensáveis para diversos sujeitos que se formaram a partir de outras linguagens, culturas e tradições diversas da concepção tradicional de secularismo. Como, então, pensar a questão do reconhecimento, no âmbito da relação entre secularismo e religião? (shrink)

Resumo: Esta é uma leitura onto-topológica de Nietzsche inspirada na microesferologia de Peter Sloterdijk. Trabalha com a diferença entre "mergulhar no mundo" e "recuar". Essa diferença permite acessar de modo concreto a posição do avaliador de medidas e genealogista. Palavras-chave: Nietzsche; onto-topologia; estranhamento; Sloterdijk; self negativo.

Previous studies have consistently argued that employees' perception of their leaders as charismatic will positively influence their willingness to commit themselves to the ethical and philanthropic objectives of the organization. However, the empirical relationship between charisma and employee work effort is only modestly explored. This study hypothesizes that in decentralized, professional, and normative organizations characterized by demanding and philanthropic tasks, group belonging, in its capacity to socially and professionally support employees, is better suited to explain employee work effort than leadership (...) charisma. Hierarchical regression analyses based on data from a bishopric supported this assumption. Practical and theoretical consequences are discussed. (shrink)

This article outlines a genealogical profile of an elusive doctrinal concept that, after being discussed in several Mahāyāna sutras, had a significant impact on East Asian Buddhist traditions. This notion is known as ‘playful samādhi’, in Chinese youxi sanmei 遊戲三昧, which translates to Sanskrit vikrīḍita samādhi. The compound youxi 遊戲 (‘playful’ – ‘at play’) was cited in Chinese sutras and Buddhist documents, in renowned and widely diffused collections of gongans/kōans 公案, was expounded and commented on by Dōgen Zenji 道元禅師 (1200–1253) (...) in its Japanese version yuge 遊戲 and was explored by modern scholars and interpreters as Ryōsuke Ōhashi 大橋良介 and Wu Rujun 吳汝均, who compares youxi 遊戲 with Schiller’s Spieltrieb. Given the significance of ‘playful samādhi’ across different epochs and cultures, I believe a clarification of the term is especially needed. Furthermore, explicit reference to contemporary scholarship on play studies can help uncover its philosophical implications, shedding new light on a complex notion that defies a univocal interpretation and reunites in its semantic field both the aesthetic and religious dimensions. (shrink)

I examine the question of whether people are sometimes morally blameworthy for what I call ‘slips’: wrongful actions or omissions that a good-willed agent inadvertently performs due to a non-negligent failure to be aware of relevant considerations. I focus in particular on the capacitarian answer to this question, according to which possession of the requisite capacities to be aware of relevant considerations and respond appropriately explains blameworthiness for slips. I argue, however, that capacitarianism fails to show that agents have responsibility (...) level control over their slips and, consequently, fails to show that it is reasonable to expect agents to avoid this kind of wrongdoing. I conclude that people are typically not blameworthy for their slips, but only regarding the backward-looking, desert-entailing type of blame that has been at issue in this debate. I suggest that ordinary intuitions about blameworthiness for slips can be accommodated by appealing to other types of responsibility and blame. (shrink)

The article explores similarities between the philosophies of Zhuangzi and Aristippus, focusing in particular on play and eudaimonism. The main thesis is that both authors encourage the cultivation of a playful mindset, defined in the paper as the “ludic self”, which operates as a strategy for leading a flourishing life. By shaping a fluid, unstructured identity, the ludic self promotes negative subtraction from the structuring power of social nexus and proactive adaptation to shifting circumstances. Furthermore, some aspects of these philosophies (...) present an inter-disciplinary convergence with scientific findings from the psycho-biology of play, concerned with the mobilization of cathected energies and the prevention, or resolution, of addictive states. These promising connections with the fields of psychology and biology also represent an original contribution in respect to the existing debates within Zhuangzi studies, and scholarship on the Cyrenaics. From a methodological point of view, the article pursues what Rorty defines as a “rational reconstruction”, which involves a re-interpretation of past philosophies in light of present debates, ideas and vocabularies with the aim of engaging a trans-cultural, trans-historical dialogue. The value of this operation relies upon the universality of human experience, which always allows re-interpretation and re-actualization of past philosophies as a dialogical exercise of questioning otherness within a hermeneutic framework. (shrink)

Notwithstanding the general rise of experimental disciplines in biology in the first decades of our century, in Germany and in the Netherlands the interest in the idealistic morphological tradition flourished, and compensated for a reductionistic causal approach to natural phenomena. This article analyses the influence of the German idealistic morphologists W. Lubosch and A. Meyer on the development of C.J. van der Klaauw's epistemology. It discusses the gradual incorporation of non-causal principles into van der Klaauw's concept of biology. Van der (...) Klaauw's epistemological concept of holistic biology was shaped in a critical confrontation with German idealistic morphology, and his early considerations can be interpreted as a direct impulse towards the development of his theory of functional components. Van der Klaauw's theories, being an alternative to the reductionistic experimental sciences, were among the causes of the fact that in the first half of our century biology in the Netherlands took a course deviating from the development of biology in the Anglo-American countries. (shrink)

Ignorance usually excuses from responsibility, unless the person is culpable for the ignorance itself. Since a lot of wrongdoing occurs in ignorance, the question of what makes ignorance culpable is central for a theory of moral responsibility. In this article I examine a prominent answer, which I call the ‘volitionalist tracing account,’ and criticize it on the grounds that it relies on an overly restrictive conception of responsibility‐relevant control. I then propose an alternative, which I call the ‘capacitarian conception of (...) control,’ and on the basis of it I advance an account of culpable ignorance that avoids the skeptical upshots of the volitionalist proposal. If correct, my account establishes three important truths: agents can be directly in control of their ignorance, they can be directly responsible for more than actions and omissions, and their moral obligations extend beyond the performance of intentional actions and omissions. (shrink)

Western philosophy has mainly developed in accordance with the three laws of identity, noncontradiction and excluded middle, also known as “laws of thought”. Since Zen Buddhism often violates these apparently indisputable logical principles, a superficial reading may induce the idea that Zen Buddhism is a completely irrational, illogical doctrine. In this essay, I argue that Zen Buddhism is not absurd or illogical. Conversely, it relies on a different logic, which is perfectly consonant with the Buddhist view of the world.