Chronic wounds, such as diabetic foot ulcers, pose significant challenges due to their prolonged inflammation state, slow vascularization, lack of supportive matrix, and frequent recurrence. Biocompatible materials like silk fibroin (SF) and collagen can be promising in chronic wound healing applications due to their biocompatibility, and ability to act as supporting matrix necessary for tissue regeneration. This study explores the development and characterization of SF-based biomaterials in various formats, including gels, lyophilized scaffolds, and films, by combining them with collagen (Col) (...) and heparin (Hep) molecules that are known for the wound-healing properties. SF gels, films, and lyophilized scaffolds were characterized for water retention capacity, porosity, contact angle, and antibacterial properties. Curcumin-loaded films reported moderate wetting behavior but were brittle, thin and hard. Freeze-dried scaffolds possessed higher water retention capacity compared to the sonicated gels and films, and showed a porous network structure, while the fabricated SF gels disintegrated in water. SF with a chelating agent demonstrated mild antibacterial properties, which were retained when combined with Collagen peptides and Heparin. The antimicrobial effect was significantly enhanced when SF+Col+Hep was added with antimicrobial agents such as Gentamicin and Ceftriaxone. The study concludes that SF-based scaffolds, particularly those incorporating collagen peptides and heparin, can be leveraged for molecular delivery application towards wound healing. Future research should focus on improving mechanical properties, measuring release kinetics of heparin and other biomolecules from SF-based lyophilized scaffolds, and conducting in vivo studies to validate the therapeutic value. (shrink)

Kireet Joshi, b. 1931, Indian philosopher and educationist; contributed articles.

The American political landscape exhibits significant polarization. People’s political beliefs cluster around two main camps. However, many of the issues with respect to which these two camps disagree seem to be rationally orthogonal. This feature raises an epistemic challenge for the political partisan. If she is justified in consistently adopting the party line, it must be true that her side is reliable on the issues that are the subject of disagreements. It would then follow that the other side is anti-reliable (...) with respect to a host of orthogonal political issues. Yet, it is difficult to find a psychologically plausible explanation for why one side would get things reliably wrong with respect to a wide range of orthogonal issues. While this project’s empirical discussion focuses on the US context, the argument generalizes to any situation where political polarization exists on a sufficiently large number of orthogonal claims. (shrink)

Political protests, debates on college campuses, and social media tirades make it seem like everyone is speaking their minds today. Surveys, however, reveal that many people increasingly feel like they're walking on eggshells when communicating in public. Speaking your mind can risk relationships and professional opportunities. It can alienate friends and anger colleagues. Isn't it smarter to just put your head down and keep quiet about controversial topics? In this book, Hrishikesh Joshi offers a novel defense of speaking your (...) mind. He explains that because we are social creatures, we never truly think alone. What we know depends on what our community knows. And by bringing our unique perspectives to bear upon public discourse, we enhance our collective ability to reach the truth on a variety of important matters. Speaking your mind is also important for your own sake. It is essential for developing your own thinking. And it's a core aspect of being intellectually courageous and independent. Joshi argues that such independence is a crucial part of a well-lived life. The book draws from Aristotle, John Stuart Mill, Friedrich Nietzsche, Bertrand Russell, and a range of contemporary thinkers to argue that it's OK to speak your mind. Key Features Shows that we have not just a right but a moral duty to publicly share what we know. Argues that discussing your unique ideas with others is essential for developing as a critical thinker. Explores the value of intellectual honesty and independence in the writings of John Stuart Mill and Friedrich Nietzsche and connects their thinking to contemporary problems. Argues that avoiding cultural blind spots today is important for the fate of future generations. (shrink)

This paper argues for the existence of a certain type of defeater for one’s belief that P—the presence of social incentives not to share evidence against P. Such pressure makes it relatively likely that there is unpossessed evidence that would provide defeaters for P because it makes it likely that the evidence we have is a lopsided subset. This offers, I suggest, a rational reconstruction of a core strand of argument in Mill’s On Liberty. A consequence of the argument is (...) that on morally and politically laden issues in particular, a high degree of doxastic openness might be appropriate. (shrink)

According to many philosophers, the world should embrace open borders – that is, let people move around the globe and settle as they wish, with exceptions made only in very specific cases such as fugitives or terrorists. Defenders of open borders have adopted two major argumentative strategies. The first is to claim that immigration restrictions involve coercion, and then show that such coercion cannot be morally justified. The second is to argue that adopting worldwide open borders policies would make the (...) world a much better place, particularly by improving average well-being. This essay contends that both of these argumentative strategies fail. Some immigration restrictions are not only morally justified, but morally required. (shrink)

This paper critically examines moral contractarianism, a moral theory centred on rational agreements among self-interested individuals to establish moral rules and social norms. It explores the challenges faced by moral contractarianism while also highlighting its strengths. Major issues, such as accommodating justice and fairness within the contractarian framework, are discussed, along with other challenges. Additionally, the paper provides a brief discussion of moral contractualism (a theory similar to moral contractarianism in certain aspects), highlighting its strengths in addressing some of the (...) challenges faced by moral contractarianism while also discussing its limitations. The paper concludes by offering a revised framework of moral contractarianism that provides solutions to the major problems of injustice and partiality that the theory faces. (shrink)

Our moral compass is not the only thing that compels us to provide compassionate health care, which also improves patient outcomes and patient and provider satisfaction. In the current era of increasing medical complexity, provider burnout, and value-based reimbursement, health care systems struggle to durably improve their providers’ compassion in the provision of care. A religious retreat curriculum for leaders at OSF HealthCare, in Illinois and Michigan, has led to a significant, long-term increase among employees in their compassion toward patients, (...) colleagues, and self. (shrink)

Are immigration restrictions compatible with liberalism? Recently, Freiman and Hidalgo have argued that immigration restrictions conflict with the core commitments of liberalism. A society with immigration restrictions in place may well be optimal in some desired respects, but it is not liberal, they argue. So if you care about liberalism more deeply than you care about immigration restrictions, you should give up on restrictionism. You can’t hold on to both. I argue here that many restrictions on contractual, economic, and associational (...) liberties seem to be justified by considerations other than liberty – thus the task for Freiman and Hidalgo is to tell us why such restrictions are justified but immigration restrictions are not. Moreover, even if this worry can be addressed, I argue, liberalism is not committed to its own demise in scenarios where there exist large enough numbers of would-be immigrants who accept and endorse illiberal norms in a way that is sufficiently resistant to change. Such a commitment requires thinking of border coercion as violating an absolute deontological constraint. This, I contend, is implausible. (shrink)

Epistemic paternalism involves interfering with the inquiry of others, without their consent, for their own epistemic good. Recently, such paternalism has been discussed as a method of getting the broader public to have more accurate views on important policy relevant matters. In this paper, I discuss a novel problem for such paternalism—what I call epistemic spillovers. The problem arises because what matters for rational belief is one’s total evidence, and further, individual pieces of evidence can have complex interactions with one (...) another. Because of this, I argue that justified epistemic paternalism requires the would-be paternalist to be in an unusually strong epistemic position, one that most would-be paternalists are unlikely to meet. (shrink)

In philosophical work on the ethics of conversational exchange, much has been written regarding the speaker side—i.e., on the rights and duties we have as speakers. This paper explores the relatively neglected topic of the duties pertaining to listeners’ side of the exchange. Following W.K. Clifford, we argue that it’s fruitful to think of our epistemic resources as common property. Furthermore, listeners have a key role in maintaining and improving these resources, perhaps a more important role than speakers. We develop (...) this idea by drawing from Hugo Mercier and Dan Sperber’s “interactionist” picture of reason, which suggests that reasoning is essentially dialogical and relies on the epistemic vigilance of listeners. The paper defends an imperfect, prima facie duty to listen, one that is sufficiently strong to place substantial demands on individuals, but not so overly demanding as to be implausible. (shrink)

Censorship involves, inter alia, adopting a certain type of epistemic policy. While much has been written on the harms and benefits of free expression, and the associated rights thereof, the epistemic preconditions of justified censorship are relatively underexplored. In this paper, I argue that examining intrapersonal norms of how we ought to treat evidence that might come to us over time can shed light on interpersonal norms of evidence generation and sharing that are relevant in the context of censorship. The (...) upshot is that justified censorship requires the censor to meet a very high epistemic burden regarding the target proposition(s)—importantly, one that exceeds knowledge. (shrink)

According to G.A. Cohen, the principles of justice are insensitive to facts about human moral limitations. This assumption allows him to mount a powerful defense of socialism. Here, I present a dilemma for Cohen. On the one hand, if such socialism is to be realized through collective property ownership, then the information problem renders the ideal incoherent, not merely infeasible. On the other hand, if socialism is to incorporate private ownership of productive assets, then Cohen loses the resources to distinguish (...) his view from capitalism. For, if agents were ideally motivated, there would be no need for coercive taxation schemes and limitations on trade. Moreover, incorporating coercion drastically undermines Cohen’s original argument for socialism, which relies on an analogy to a camping trip among friends. (shrink)

A pervasive feature of democracy is disagreement. And in general, when we encounter disagreement from someone who is at least more reliable than chance, this puts some pressure on us to moderate our beliefs. But this raises the specter of asymmetric compliance—it’s not obvious what to do when we moderate our beliefs but the other party refuses to do so. Whereas an elegant solution is available when it comes to how we can to respond to our higher-order evidence while still (...) preserving democratic fairness, I argue that no such solution is forthcoming when we consider zetetic intransigence—that is, asymmetric compliance with regards to how we inquire, or gather evidence. The upshot is that democratic participation can involve messy tradeoffs with no entirely satisfactory resolution. (shrink)

Following Anthony Downs’s classic economic analysis of democracy, it has been widely noted that most voters lack the incentive to be well-informed. Recent empirical work, however, suggests further that political partisans can display selectively lazy or biased reasoning. Unfortunately, political knowledge seems to exacerbate, rather than mitigate, these tendencies. In this paper, I build on these observations to construct a more general skeptical challenge which affects what I call creedal beliefs. Such beliefs share three features: (i) the costs to the (...) individual of being wrong are negligible, (ii) the beliefs are subject to social scrutiny, and (iii) the evidential landscape relevant to the beliefs is sufficiently complex so as to make easy verification difficult. Some philosophers and social scientists have recently argued that under such conditions, beliefs are likely to play a signaling, as opposed to a navigational role, and that our ability to hold beliefs in this way is adaptive. However, if this is right, I argue there is at least a partial debunker for such beliefs. Moreover, this offers, I suggest, one way to develop the skeptical challenge based on etiological explanation that John Stuart Mill presents in On Liberty when he claims that the same causes which lead someone to be a devout Christian in London would have made them a Confucian in Peking. Finally, I contend that this skeptical challenge is appropriately circumscribed so that it does not over-extend in an implausible way. (shrink)

The questions of how human beings produce and comprehend language continue to engage a variety of researchers and scholars, and it is becoming increasingly clear that only interdisciplinary approaches will yield productive answers. This complex issue of discourse processing is the subject of this volume, and the contributors address it from the varying perspectives of cognitive psychology linguistics, and computer science. The chapters provide a fascinating overview of emerging theories in the new discipline of cognitive science. A useful introductory chapter (...) by the editors explains the relationships of chapters to one another and outlines the long-term implications of the work they report. (shrink)

We describe a categorial system (PPTS) based on partial proof trees(PPTs) as the building blocks of the system. The PPTs are obtained byunfolding the arguments of the type that would be associated with a lexicalitem in a simple categorial grammar. The PPTs are the basic types in thesystem and a derivation proceeds by combining PPTs together. We describe theconstruction of the finite set of basic PPTs and the operations forcombining them. PPTS can be viewed as a categorial system incorporating someof (...) the key insights of lexicalized tree adjoining grammar, namely the notionof an extended domain of locality and the consequent factoring of recursionfrom the domain of dependencies. PPTS therefore inherits the linguistic andcomputational properties of that system, and so can be viewed as a middleground between a categorial grammar and a phrase structure grammar. We alsodiscuss the relationship between PPTS, natural deduction, and linear logicproof-nets, and argue that natural deduction rather than a proof-net systemis more appropriate for the construction of the PPTs. We also discuss howthe use of PPTs allows us to localize the management of resources, therebyfreeing us from this management as the PPTs are combined. (shrink)

Within the immigration debate, libertarians have typically come down in favor of open borders by defending two main ideas: i) individuals have a right to free movement; and ii) immigration restrictions are economically inefficient, so that lifting them can make everyone better off. This entry describes the rationale for open borders from a libertarian perspective (in part by analogy to the debate around minimum wage laws). Three main objections within the immigration literature are then discussed: i) the view that states (...) may restrict immigration to protect the interests (e.g. jobs) of their domestic needy; ii) the claim that restrictions are justified as a means of preserving culture; and iii) the influential argument that the right to freedom of association entails a right to exclude. These arguments are well-known, and I describe some of the compelling responses to be found in the recent literature. The essay then turns to more neglected critiques. The first concerns how liberal regimes should think about immigration from countries where the dominant norms are illiberal. The second examines the idea that political and economic institutions are sensitive to immigration policy, especially in the long run. Both of these critiques approach the topic from a non-ideal theory perspective, emphasizing the “public choice” dimensions of immigration policy. The entry closes by suggesting that this form of critique is especially important for open-borders libertarians to respond to given their general commitments to non-ideal, non-romantic theorizing in the context of government institutions and policy. (shrink)

The term Bāul is universally associated with singing. It is a form of folk music that emerges from Bengal in India. However, Bāul does not simply imply singing. It is more of a philosophy which is deeply rooted in the quest for self-realization. The raison d’être for the kind of attraction the music of Bāuls and the poetry of Kabir had for the West is that their music and poetry was essentially a poetry of simplicity, peace and celestial love. Since (...) Bāul music and Kabir’s poetry transcends religious boundaries, it was easily accepted by the Western canon that was looking to the East for newer inspiration and life philosophies. This paper focuses on the oral Indian tradition of Bāulgan and the Dohas of Kabir and how they influenced the writing of the legendary Beat poet Allen Ginsberg. The paper also partially focuses on Purna Das and Laxman Das, two famous Bāul singers who went to live in Woodstock at the house of Bob Dylan in the mid-1960s and their resulting friendship. (shrink)

In eukaryotic cells a specialized organelle called the microtubule organizing center (MTOC) is responsible for disposition of microtubules in a radial, polarized array in interphase cells and in the spindle in mitotic cells. Eukaryotic cells across different species, and different cell types within single species, have morphologically diverse MTOCs, but these share a common function of organizing microtubule arrays. MTOCs effect microtubule organization by initiating microtubule assembly and anchoring microtubules by their slowly growing minus ends, thus ensuring that the rapidly (...) growing plus ends extend distally in each microtubule array. The goal is to define molecular components of the MTOC responsible for regulating microtubule assembly. One approach to defining the molecules responsible for MTOC function is to look for molecules common to all MTOCs. A newly discovered centrosomal protein, γ‐tubulin, is found in MTOCs in cells from many different organisms, and has several properties which make it a candidate for both initiation of microtubule assembly and anchorage. The hypothesis that γ‐tubulin plays a role in MTOCs in microtubule initiation and anchorage is currently being tested by a variety of experimental approaches. (shrink)

This chapter argues that governments have a duty to take reasonably effective and humane steps to minimize the occurrence of unauthorized migration and stay. While the effects of unauthorized migration on a country’s citizens and institutions have been vigorously debated, the literature has largely ignored duties of fairness to would-be immigrants. It is argued here that failing to take reasonable steps to prevent unauthorized migration and stay is deeply unfair to would-be immigrants who are not in a position to bypass (...) visa regulations. Importantly, the argument here is orthogonal to the debate as to how much and what kinds of immigration ought to be allowed. (shrink)

This paper addresses the problem of Twitter sentiment analysis through a hybrid approach in which SentiWordNet (SWN)-based feature vector acts as input to the classification model Support Vector Machine. Our main focus is to handle lexical modifier negation during SWN score calculation for the improvement of classification performance. Thus, we present naive and novel shift approach in which negation acts as both sentiment-bearing word and modifier, and then we shift the score of words from SWN based on their contextual semantic, (...) inferred from neighbouring words. Additionally, we augment negation accounting procedure with a few heuristics for handling the cases in which negation presence does not necessarily mean negation. Experimental results show that the contextual-based SWN feature vector obtained through shift polarity approach alone led to an improved Twitter sentiment analysis system that outperforms the traditional reverse polarity approach by 2–6%. We validate the effectiveness of our hybrid approach considering negation on benchmark Twitter corpus from SemEval-2013 Task 2 competition. (shrink)

Consider a binary afterlife, wherein some people go to Heaven, others to Hell, and nobody goes to both. Would such a system be just? Theodore Sider argues: no. For, any possible criterion of determining where people go will involve treating very similar individuals very differently. Here, I argue that this point has deep and underappreciated implications for moral philosophy. The argument proceeds by analogy: many ethical theories make a sharp and practically significant distinction between persons and non-persons. Yet, just like (...) in the binary afterlife, this involves treating very similar individuals very differently. I propose two ways out. The first is to deny that such theories are strictly speaking true, but to claim that it is practically best if people adopt them. The second is to modify such theories so as to allow for continuous variation in the scope and strength of the moral obligations arising from personhood. (shrink)

The role of antibody-antigen affinity and concentrations in adaptive antibody response is analyzed in a framework of probabilistic inventory model for antibody production. Our results indicate significant differences in optimal behaviours of low, moderate and high affinity groups and offer important implications. Interestingly, the involved approach is also of relevance in other production systems. Directions for its applications in industries and information sciences are also presented.

The word “privilege” has become a part of our everyday conversations. However, it is not evident whether the various interlocutors in discussions on privilege are using it in the same sense. While different instances of privilege like white, male, or caste privilege have been discussed in contemporary academic discourses, we believe there is a lack of clarity regarding the notion of privilege. We critically analyse existing accounts of privilege to show that they leave some room for improvement. We offer an (...) alternative account of privilege as “entitlements that fail to track deserts” that circumvents prevalent definitional ambiguities and emphasises the inherent undeserving nature of privilege. The hitherto underexplored links between privileges, deserts, entitlements, and rights can help us formulate a more accurate grasp of privilege. (shrink)

Where does normativity come from? Or alternatively, in virtue of what do facts about what an agent has reason to do obtain? On one class of views, reason facts obtain in virtue of agents’ motivations. It might seem like a truism that at least some of our reasons depend on what we desire or care about. However, some philosophers, notably Derek Parfit, have convincingly argued that no reasons are grounded in this way. Typically, this latter, externalist view of reasons has (...) been thought to enjoy the advantage of extensional adequacy—that is, the ability to account for all the reasons we intuitively think people have. This paper provides a novel argument against this assumption by considering a type of case wherein the relative strengths of the agent’s reasons can only be adequately explained by reference to what she cares about. Adding some further assumptions yields that there are at least some internally sourced reasons. (shrink)