Understanding the clinical significance of variants associated with hereditary cancer risk requires access to a pooled data resource or network of resources—a “cancer gene variant commons”—incorporating representative, well-characterized genetic data, metadata, and, for some purposes, pathways to case-level data. Several initiatives have invested significant resources into collecting and sharing cancer gene variant data, but further progress hinges on identifying and addressing unresolved policy issues. This commentary provides insights from a modified policy Delphi process involving experts from a range of stakeholder (...) groups involved in the data-sharing ecosystem. In particular, we describe policy issues and options generated by Delphi participants in five domains critical to the development of an effective cancer gene variant commons: incentives, financial sustainability, privacy and security, equity, and data quality. Our intention is to stimulate wider discussion and lay a foundation for further work evaluating policy options more in-depth and mapping them to those who have the power to bring about change. Addressing issues in these five domains will contribute to a cancer gene variant commons that supports better care for at-risk and affected patients, empowers patient communities, and advances research on hereditary cancers. (shrink)

In this paper, we explore the perspectives of expert stakeholders about who owns data in a medical information commons and what rights and interests ought to be recognized when developing a governance structure for an MIC. We then examine the legitimacy of these claims based on legal and ethical analysis and explore an alternative framework for thinking about participants' rights and interests in an MIC.

The COVID-19 pandemic has raised a host of ethical challenges, but key among these has been the possibility that health care systems might need to ration scarce critical care resources. Rationing p...

Drawing on a landscape analysis of existing data-sharing initiatives, in-depth interviews with expert stakeholders, and public deliberations with community advisory panels across the U.S., we describe features of the evolving medical information commons. We identify participant-centricity and trustworthiness as the most important features of an MIC and discuss the implications for those seeking to create a sustainable, useful, and widely available collection of linked resources for research and other purposes.

As the federal government continues to expand upon and improve its data sharing policies over the past 20 years, complex challenges remain. Our interviews with U.S. academic genetic researchers (n=23) found that the burden, translation, industry limitations, and consent structure of data sharing remain major governance challenges.

A 2011 National Academies of Sciences report called for an “Information Commons” and a “Knowledge Network” to revolutionize biomedical research and clinical care. We interviewed 41 expert stakeholders to examine governance, access, data collection, and privacy in the context of a medical information commons. Stakeholders' attitudes about MICs align with the NAS vision of an Information Commons; however, differences of opinion regarding clinical use and access warrant further research to explore policy and technological solutions.

Making data broadly accessible is essential to creating a medical information commons. Transparency about data-sharing practices can cultivate trust among prospective and existing MIC participants. We present an analysis of 34 initiatives sharing DNA-derived data based on public information. We describe data-sharing practices captured, including practices related to consent, privacy and security, data access, oversight, and participant engagement. Our results reveal that data-sharing initiatives have some distance to go in achieving transparency.

A medical information commons is a networked data environment utilized for research and clinical applications. At three deliberations across the U.S., we engaged 75 adults in two-day facilitated discussions on the ethical and social issues inherent to sharing data with an MIC. Deliberants made recommendations regarding opt-in consent, transparent data policies, public representation on MIC governing boards, and strict data security and privacy protection. Community engagement is critical to earning the public's trust.

Advances in technologies and biomedical informatics have expanded capacity to generate and share biomedical data. With a lens on genomic data, we present a typology characterizing the data-sharing landscape in biomedical research to advance understanding of the key stakeholders and existing data-sharing practices. The typology highlights the diversity of data-sharing efforts and facilitators and reveals how novel data-sharing efforts are challenging existing norms regarding the role of individuals whom the data describe.

That the central thesis of Donald Davidson’s classic article on metaphor “What Metaphor Means” (WMM) is ambiguous between a weak and a strong interpretation is the primary claim that I sought to establish in my article “Sentence Meaning, Speaker Meaning, and Davidson’s Denial of Metaphorical Meaning.” In addition to this, I argued that the weak claim is trivially true and the strong claim is obviously false. Therefore, I concluded that when the central thesis of WMM is disambiguated, it is insignificant. (...) Finally, I explained the ambiguity in that thesis in terms of Davidson’s neglect in WMM for the concept of speaker meaning and this, in turn, in terms of a certain theoretical orientation to language that Davidson held at the time of writing WMM. In his commentary on my article, “Speaker Meaning and Davidson on Metaphor: A Reply to McGuire,” Robert J. Stainton raises objections to several of the foregoing claims. In this article, I review and defend each of these claims against Stainton’s objections. (shrink)

We argue that Isaac Newton really is best understood as being in the tradition of the Mechanical Philosophy and, further, that Newton saw himself as being in this tradition. But the tradition as Newton understands it is not that of Robert Boyle and many others, for whom the Mechanical Philosophy was defined by contact action and a corpuscularean theory of matter. Instead, as we argue in this paper, Newton interpreted and extended the Mechanical Philosophy's slogan “matter and motion” in (...) reference to the long and distinguished tradition of mixed mathematics and the study of simple machines. (shrink)

If anyone deserves the title "father of social cognition," it is William J. McGuire who, along with his wife and colleague Claire V. McGuire, has written the ...

John Michael McGuire presents a dilemma for Donald Davidson’s denial of metaphorical content in the latter’s “What Metaphors Mean”. Probably, says McGuire, Davidson has simply overlooked the possibility that speakers mean propositions when they speak metaphorically. If so, all Davidson is saying is that expressions do not have additional metaphorical meanings. This is so obvious as to make Davidson’s paper “insignificant”. Besides which, McGuire continues, if Davidson intended to deny that speakers mean propositions in speaking metaphorically, his (...) view is “obviously false”. This again would make Davidson’s supposedly classic paper “insignificant.”. (shrink)

THERE IS WIDESPREAD AGREEMENT among historians that the writings of Robert Boyle (1697-1691) constitute a valuable archive for understanding the concerns of seventeenth-century British natural philosophers. His writings have often been seen as representing, in one fashion or another, all of the leading intellectual currents of his day. ~ There is somewhat less consensus, however, on the proper historiographic method for interpreting these writings, as well as on the specific details of the beliefs expressed in them. Studies seeking to (...) explicate Boyle's thought have been, roughly speaking, of two general sorts. On the one hand there are those studies of a broadly "intellectualist" orientation which situate his natural philosophy within the intellectual context provided by metaphysics, religion, and early modern science. In this connection his corpuscularianism has been shown to be motivated by specific epistemological, theological, as well as empirical concerns. One of the central aims of such studies has been to show that apparently discordant elements in his scientific thought are rendered coherent by referring them to such "non-scientific" commitments. Among studies of this sort might be mentioned the works of John Hedley Brooke, E. A. Burtt, Gary B. Deason, J. E. McGuire, R. Hooykaas, Robert H. Kargon, Eugene M. Klaaren, P. M. Rattansi, and Richard S. Westfall. (shrink)

This fresh and original book argues that the central questions in Hegel's practical philosophy are the central questions in modern accounts of freedom: What is freedom, or what would it be to act freely? Is it possible so to act? And how important is leading a free life? Robert Pippin argues that the core of Hegel's answers is a social theory of agency, the view that agency is not exclusively a matter of the self-relation and self-determination of an individual (...) but requires the right sort of engagement with and recognition by others. Using a detailed analysis of key Hegelian texts, he develops this interpretation to reveal the bearing of Hegel's claims on many contemporary issues, including much-discussed core problems in the liberal democratic tradition. His important study will be valuable for all readers who are interested in Hegel's philosophy and in the modern problems of agency and freedom. (shrink)

This essay presents a version of divine command metaethics inspired by recent work of Donnellan, Kripke, and Putnam on the relation between necessity and conceptual analysis. What we can discover a priori, by conceptual analysis, about the nature of ethical wrongness is that wrongness is the property of actions that best fills a certain role. What property that is cannot be discovered by conceptual analysis. But I suggest that theists should claim it is the property of being contrary to the (...) commands of a loving God. This claim, if true, is a necessary but not an a priori truth. It also is a claim, not about the way in which some believers use the word 'wrong,' but about the wrongness that virtually everyone talks about. This position is distinguished from the author's previous views, and from a holistic development of the latter proposed by Jeffrey Stout. (shrink)

The paper is an interpretation and defense of Kant's conception of things in themselves as noumena, along the following lines. Noumena are transempirical realities. As such they have several important roles in Kant's critical philosophy (Section 1). Our theoretical faculties cannot obtain enough content for a conception of noumena that would assure their real possibility as objects, but can establish their merely formal logical possibility (Sections 2-3). Our practical reason, however, grounds belief in the real possibility of some noumena, and (...) even knowledge of the noumenal reality of a free will (Section 4). Section 5 defends Kant's conception of noumena as a good piece of philosophy, particularly with respect to its distinction between logical and real possibility. Are noumena numerically identical with experienced (phenomenal) objects? Kantian principles yield the answers that human selves are, God isn't, and it's harder to say about bodies (Section 6). (shrink)

This is the first book to explore the cognitive science of effortless attention and action. Attention and action are generally understood to require effort, and the expectation is that under normal circumstances effort increases to meet rising demand. Sometimes, however, attention and action seem to flow effortlessly despite high demand. Effortless attention and action have been documented across a range of normal activities--from rock climbing to chess playing--and yet fundamental questions about the cognitive science of effortlessness have gone largely unasked. (...) -/- This book draws from the disciplines of cognitive psychology, neurophysiology, behavioral psychology, genetics, philosophy, and cross-cultural studies. Starting from the premise that the phenomena of effortless attention and action provide an opportunity to test current models of attention and action, leading researchers from around the world examine topics including effort as a cognitive resource, the role of effort in decision making, the neurophysiology of effortless attention and action, the role of automaticity in effortless action, expert performance in effortless action, and the neurophysiology and benefits of attentional training. -/- Contributors: Joshua M. Ackerman, James H. Austin, John A. Bargh, Roy F. Baumeister, Sian L. Beilock, Chris Blais, Matthew M. Botvinick, Brian Bruya, Mihaly Csikszentmihalyi, Marci S. DeCaro, Arne Dietrich, Yuri Dormashev, László Harmat, Bernhard Hommel, Rebecca Lewthwaite, Örjan de Manzano, Joseph T. McGuire, Brian P. Meier, Arlen C. Moller, Jeanne Nakamura, Evgeny N. Osin, Michael I. Posner, Mary K. Rothbart, M. R. Rueda, Brandon J. Schmeichel, Edward Slingerland, Oliver Stoll, Yiyuan Tang, Töres Theorell, Fredrik Ullén, Robert D. Wall, Gabriele Wulf. (shrink)

Neo-teleology is the two part thesis that, e.g., (i) we have hearts because of what hearts are for: Hearts are for blood circulation, not the production of a pulse, so hearts are there--animals have them--because their function is to circulate the blood, and (ii) that (i) is explained by natural selection: traits spread through populations because of their functions. This paper attacks this popular doctrine. The presence of a biological trait or structure is not explained by appeal to its function. (...) To suppose otherwise is to trivialize natural selection. (shrink)

Mit diesem Buch wird erstmals ein umfassendes und systematisches Referenzwerk zu Christian Wolff vorgelegt, das alle wichtigen Aspekte zu Leben und Werk des Philosophen behandelt. Das Handbuch ist von international renommierten Experten verfasst und behandelt neben der Biographie und der philosophiegeschichtlichen Rolle Wolffs sowohl sein philosophisches als auch sein naturwissenschaftlich-mathematisches Werk.

The book aims to revitalise the interdisciplinary debate about evolutionary ethics and substantiate the idea that evolution science can provide a rational and robust framework for understanding morality. It also traces pathways for knowledge-based choices to be made about directions for future long-term biological evolution and cultural development in view of adaptation to the expected, probable and possible future and the ecological sustainability of our planetary environment The authors discuss ethical challenges associated with the major biosocial sources of human variation: (...) individual variation, inter-personal variation, inter-group variation, and inter-generational variation. This book approaches the long-term challenges of the human species in a holistic way. Researchers will find an extensive discussion of the key theoretical scientific aspects of the relationship between evolution and morality. Policy makers will find information that can help them better understand from where we are coming and inspire them to make choices and take actions in a longer-term perspective. The general public will find food for thoughts. (shrink)

Natural selection is commonly interpreted as the fundamental mechanism of evolution. Questions about how selection theory can claim to be the all-sufficient explanation of evolution often go unanswered by today's neo-Darwinists, perhaps for fear that any criticism of the evolutionary paradigm will encourage creationists and proponents of intelligent design.In Biological Emergences, Robert Reid argues that natural selection is not the cause of evolution. He writes that the causes of variations, which he refers to as natural experiments, are independent of (...) natural selection; indeed, he suggests, natural selection may get in the way of evolution. Reid proposes an alternative theory to explain how emergent novelties are generated and under what conditions they can overcome the resistance of natural selection. He suggests that what causes innovative variation causes evolution, and that these phenomena are environmental as well as organismal.After an extended critique of selectionism, Reid constructs an emergence theory of evolution, first examining the evidence in three causal arenas of emergent evolution: symbiosis/association, evolutionary physiology/behavior, and developmental evolution. Based on this evidence of causation, he proposes some working hypotheses, examining mechanisms and processes common to all three arenas, and arrives at a theoretical framework that accounts for generative mechanisms and emergent qualities. Without selectionism, Reid argues, evolutionary innovation can more easily be integrated into a general thesis. Finally, Reid proposes a biological synthesis of rapid emergent evolutionary phases and the prolonged, dynamically stable, non-evolutionary phases imposed by natural selection. (shrink)

In this paper, we will consider a phenomenon known as inverse linking, a term coined by May (1977) to describe the most salient readings of sentences such as “Someone from every city despises it.”.

Author Robert Wright shows how Buddhist meditative practice can loosen the grip of anxiety, regret, and hatred, and deepen your appreciation of beauty and other people." -- Adapted from book jacket.

Hegel's holistic metaphysics challenges much recent ontology with its atomistic and reductionist assumptions; Stern offers us an original reading of Hegel and contrasts him with his predecessor, Kant.

One of the leading thinkers to emerge in the postwar conservative intellectual revival was the sociologist Robert Nisbet. His book The Quest for Community, published in 1953, stands as one of the most persuasive accounts of the dilemmas confronting modern society. Nearly a half century before Robert Putnam documented the atomization of society in Bowling Alone, Nisbet argued that the rise of the powerful modern state had eroded the sources of community—the family, the neighborhood, the church, the guild. (...) Alienation and loneliness inevitably resulted. But as the traditional ties that bind fell away, the human impulse toward community led people to turn even more to the government itself, allowing statism—even totalitarianism—to flourish. This edition of Nisbet’s magnum opus features a brilliant introduction by New York Times columnist Ross Douthat and three critical essays. Published at a time when our communal life has only grown weaker and when many Americans display cultish enthusiasm for a charismatic president, this new edition of The Quest for Community shows that Nisbet’s insights are as relevant today as ever. (shrink)

The first unquestionably big idea in the history of philosophy was the idea of form. The idea of course belonged to Plato, and was then domesticated at the hands of Aristotle, who paired form with matter as the two chief principles of his metaphysics and natural philosophy. In the medieval period, it was Aristotle’s conception of form and matter that generally dominated. This was true for both the Islamic and the Christian tradition, once the entire Aristotelian corpus became available. For (...) this reason, although there is much to say about the fate of Platonic Forms in medieval thought, the present chapter will focus on the Aristotelian tradition.1 Aristotelian commentators have been puzzled by form and matter for as long as there have been Aristotelian commentators. Indeed, it would not be too much to say that these are topics about which Aristotelians have never formed a very clear conception, and that their failure to do so was the principal reason why Aristotelianism ceased to be a flourishing research program from the seventeenth century onward. For those who aspire to a modern revival of Aristotelianism, the concepts of form and matter can easily take on the aspect of a kind of Holy Grail, such that if only we could get these ideas clearly in focus, we could see our way forward on any number of philosophical fronts, such as the union of mind and body, the coherence and endurance of substances, the nature of causality, and so on. The historical record, however, suggests that this hope is a snare and delusion, insofar as there has never been any such thing as the theory of form and matter. Although medieval philosophers of all kinds used this terminology incessantly, it had no more of a fixed meaning than does the ubiquitous contemporary philosophical talk of “properties.” Hence, the most a general survey of the topic can do is consider some of the more important areas of agreement and disagreement. (shrink)

It is important to distinguish between two ways in which God might be timelessly eternal: eternality as being wholly outside of time, versus the sort of timelessness that consists in lacking temporal parts, and so existing “all at once.” A prominent but neglected historical tradition, most clearly evident in Anselm, advocates putting God in time, but in an all-at-once sort of way that makes God immune to temporal change. This is an intrinsically plausible conception of divine eternality, which also sheds (...) light on the modern dispute over the endurance or perdurance of material objects. (shrink)