Neural crest cells are multipotent progenitors, capable of producing diverse cell types upon differentiation. Recent studies have identified significant heterogeneity in both the fates produced and genes expressed by different premigratory crest cells. While these cells may be specified toward particular fates prior to migration, transplant studies show that some may still be capable of respecification at this time. Here we summarize evidence that extracellular signals in the local environment may act to specify premigratory crest and thus generate diversity in (...) the population. Three main classes of signals–Wnts, BMP2/BMP4 and TGFβ1,2,3–have been shown to directly influence the production of particular neural crest cell fates, and all are expressed near the premigratory crest. This system may therefore provide a good model for integration of multiple signaling pathways during embryonic cell fate specification. BioEssays 22:708–716, 2000. © 2000 John Wiley & Sons, Inc. (shrink)

Is freedom a Western concept? As a multifaceted human experience it seems fairly transcultural. Freedom is hardly a focus of philosophical discourses in China as it is in the West, and I suppose this partly accounts for the difficulty in tracking freedom and closely related notions of agency, choice, and autonomy in Chinese philosophy.Over four decades ago Herbert Fingarette raised the controversial idea about the absence of freedom in Confucian ethics. Although not intending to denigrate, Fingarette raised a polemic that (...) has lingered to the present.1 A. C. Graham noted the sour upshot of the issue when writing that "the claim that the concept of moral choice is foreign to Confucius has offended... (shrink)

While critically examining the techno-scientific thrust that props the discourse of sustainability, this paper argues for the inclusion of the humanities and the imaginative counterworlds and complex ontological perspectives that literature offers. As Donna Haraway proposes, “we need stories (and theories) that are just big enough to gather up the complexities and keep the edges open and greedy for surprising new and old connections” (2015: 160). The Indian graphic novel Bhimayana and the artisanal aesthetic of the tribal artists is read (...) for the ways in which it mediates current debates on the posthuman, offering the possibility of intimate affirmative relationalities that could create sustainable futures. (shrink)

This book explores the significance of archery as ritual practice and literary metaphor in classical Confucian texts. Archery passages in the Analects, Mencius, and Xunzi are discussed in the light of Zhou culture and the troubled historical circumstances of early followers of the ruist master Confucius.

Emerging empirical evidence indicates that discrete emotions are associated with teaching practices and professional experiences of university instructors. However, further investigations are necessary given that university instructors often face high job demands and compromised well-being. Achievement goals, which frame achievement-related thoughts and actions, have been found to describe motivational differences in university instructors and are hypothesized to be associated with their discrete emotions. Moreover, as variation exists in how university instructors respond to job demands regarding their emotional experiences, certain goals (...) may moderate this relationship on the basis of framing different interpretations and reactions to stressors. To investigate these links, 439 instructors (46.7% female) from German and Austrian universities completed a survey assessing their achievement goals, discrete emotions (enjoyment, pride, anger, anxiety, shame, and boredom), and job demands. As hypothesized, multiple regression analyses revealed that achievement goals were differentially and meaningfully associated with discrete emotions. Specifically, learning approach goals were positively related to enjoyment and negatively related to anger and boredom, while learning avoidance goals were positively related to anger. Performance (appearance) approach goals were positively related to pride, and performance (appearance) avoidance goals were positively related to anxiety and shame. Lastly, relational goals were positively related to shame and boredom, and work avoidance goals were negatively related to enjoyment and positively related to shame and boredom. Conclusive moderation effects on the relations between job demands and emotions were not found. Future research avenues aimed at further understanding the supportive role that achievement goals can have for university instructors’ emotional experiences and well-being are discussed. (shrink)

In 2014, Brett Bailey’s Exhibit B site-specific installation created a media storm and protests throughout Europe. One such protest was in London, leading to the cancellation of his show at the Barbican. Consternation caused by art work is not a new phenomenon, and indeed one of the enduring purposes of art is to push the boundaries of acceptability and to show sights that are normally kept hidden from the public gaze. From some of the Impressionists’ exhibits to twentieth century art (...) works such as Andres Serrano’s Piss Christ in 1987 and Chris Ofili’s The Holy Virgin Mary 1996, art has caused offence in a variety of ways. This article examines Exhibit B to identify the reasons for its reception. In broad outline, as a white artist his presentation of black oppression was regarded at best as naïve and at worse as culturally inappropriate. (shrink)

According to a prominent view of organism persistence, organisms cease to exist at death. According to a rival view, organisms can continue to exist as dead organisms. Most of the arguments in favor of the latter view rely on linguistic and common sense intuitions. I propose a new argument for somaticism by appealing to two other sources that have thus far not figured in the debate: the concept of naturalness, and biological descriptions of organisms, in particular in ethology and ecology. (...) I show that if we hone in on the relevant notion of naturalness, we can show that organisms can continue to instantiate the natural property being an organism after death. (shrink)

Metaphor study is a promising trend in present-day academia. Scholars of antiquity are already profiting from it in their study of early texts. We have yet, however, to harness the potentials of metaphor in East-West comparison. The article discusses what literary metaphors are, in particular how they generate images and perspectives that call into play a broad range of extra-textual information about the speaker and his milieu. Shared metaphors are doubly advantageous: they serve as hermeneutic tools for reading early texts (...) and are fulcrums for comparing views of different traditions. Archery is an example of a shared metaphor in the Confucian Analects and Aristotle’s Nicomachean Ethics. It seems that while both texts employ images that are close together, their meanings are far apart. (shrink)

According to constitution views of persons, we are constituted by spatially coinciding human animals. Constitution views face an ‘overpopulation’ puzzle: if the animal has my brain, there is another thinker where I am. An influential solution to this problem distinguishes between derivative and non‐derivative property possession: persons non‐derivatively have their personal properties, while inheriting others from their constituters. I will show that this solution raises a new problem, by constructing a puzzle with the absurd result that we instantiate certain properties (...) incompatibly. In setting up the puzzle, I demonstrate the relevance of the bodily awareness and self‐awareness literatures to overpopulation puzzles. (shrink)

In the past two decades, Ukraine has significantly deepened its relations with NATO. Following Russia’s seizure of Crimea and instigation of conflict in the eastern Ukrainian region of Donbas in 2014, Ukraine’s interest in NATO entry has particularly intensified. According to public opinion polls in Ukraine, membership in the Alliance is critical to the country’s security. On the other hand, Russia presents the further expansion of NATO to the east as the main threat to its national security. The current developments (...) on the ground and the ongoing war between Ukraine and Russia will affect NATO’s attitude towards Ukraine’s membership prospects in the Alliance. The potential for further escalation of the war in Ukraine is significant, although it is more likely that the war will flare up and target Ukrainian forces and the civilian population, but the likelihood of the involvement of the Western Allies in the conflict is also more certain. Ukrainian authorities will have to limit their expectations for NATO membership and focus only on maximum cooperation with the Alliance. (shrink)

According to the thinking parts problem, any part sufficient for thought—e.g. a head—is a good candidate for being a thinker, and therefore being us. So we can’t assume that we—thinkers—are human beings rather than their proper parts. Many solutions to this problem have been proposed. However, I will show that the views currently on the market all face serious problems. I will then offer a new solution that avoids these problems. The thinking parts problem arises from considerations that seem to (...) be empirically substantiated. One virtue of my solution is that in addition to its theoretical apparatus it appeals to empirically substantiated considerations. (shrink)

ABSTRACTZhi is an important Chinese notion that conveys among other things human capacity to set aims, to determine a course of action, or to persist in a resolve. The term naturally turns up in Chinese contributions to Western Free Will debate. In this paper, I explain zhi by working out a comparison that goes from East to West. I do a three-fold textual analysis of zhi focusing on the Mencius. I outline different usages found in the text, examine a nuanced, (...) dominant meaning suggested in 2A.2, and discuss notional features based on language patterns. My analysis yields a more homegrown understanding of zhi which I shall compare with Western expressions of moral agency. (shrink)

The appropriate understanding and fast processing of lengthy legal documents are computationally challenging problems. Designing efficient automatic summarization techniques can potentially be the key to deal with such issues. Extractive summarization is one of the most popular approaches for forming summaries out of such lengthy documents, via the process of summary-relevant sentence selection. An efficient application of this approach involves appropriate scoring of sentences, which helps in the identification of more informative and essential sentences from the document. In this work, (...) a novel sentence scoring approach DCESumm is proposed which consists of supervised sentence-level summary relevance prediction, as well as unsupervised clustering-based document-level score enhancement. Experimental results on two legal document summarization datasets, BillSum and Forum of Information Retrieval Evaluation (FIRE), reveal that the proposed approach can achieve significant improvements over the current state-of-the-art approaches. More specifically it achieves ROUGE metric F1-score improvements of (1−6)% and (6−12)% for the BillSum and FIRE test sets respectively. Such impressive summarization results suggest the usefulness of the proposed approach in finding the gist of a lengthy legal document, thereby providing crucial assistance to legal practitioners. (shrink)

This paper analyzes the implications that the linguistic formulation of the marriage provision of the Spanish Constitution of 1978 had for securing the passage in 2005 of Law 13/2005, which legalized same-sex marriage. By claiming that a semantic omission in the original legal text was a marker of distributiveness, SSM supporters aimed to avoid a constitutional amendment, and succeeded in doing so. This linguistic argument, based on implicitness, was instrumental as a subsidiary argument of political moral argumentation. Linguistic meaning therefore (...) contributed decisively to both the legal meaning of the marriage provision and the content of the law. I argue, against some assumptions in the literature stating otherwise, that linguistic meaning should not be dismissed in constitutional interpretation and adjudication. (shrink)

Metaphors have long been valued as powerful literary devices. Lately however the discovery of the cognitive content of metaphors is drawing the attention of contemporary scholars. For those of us engaged in comparative philosophy, metaphors seem to promise to be a much-needed hermeneutic tool for understanding independent traditions and working out balanced comparisons. In this paper, I shall examine two metaphors for virtue that are used in both the Confucian Analects and Aristotle’s Nicomachean Ethics. These common metaphors are archery and (...) the middle, or mean. If Confucius and Aristotle use similar images to speak of moral virtue, do they make the same claims about virtue? In other words, do these images convey the same meaning? My paper attempts to unpack the referential meanings of these metaphors by first contextualizing them and then by tracing the associated ideas and structures behind the images. (shrink)

I argue that generic generalizations expressed in language (i.e., “generics”) are apt for good clinical reasoning. I begin by introducing what generics are in language and describe two problems in the use and interpretation of generics: Generics can license inaccurate judgements about the frequency of events or properties within a group (i.e., a problem with the “truth-aptness” of generics) and can facilitate problematic beliefs about social kinds (e.g., prejudice or essentializing). I provide an account of clinical reasoning and describe some (...) features of what I call “good” clinical reasoning. I offer examples of generics in clinical contexts and examine how the two problems with generics (i.e., of truth-aptness and social generics) can be harmful to patients and impair clinical reasoning. However, I ultimately argue that generics are important for good clinical reasoning because they track “conspicuous” features of disease processes (e.g., severe possible outcomes). Further, I argue that prejudicial generics are often irrational to believe, and social generics that are rational to believe need not lead to problematic implicatures about social kinds and can, in principle, instead facilitate meaningfully articulating societal injustices. I then argue that statistical statements, which are tempting alternatives to generics in clinical reasoning, are no better than generics for good clinical reasoning, even with respect to the two problems identified in the use of generics. (shrink)

This paper argues that Samuel Beckett’s interest in functions of the brain is not only evidenced in his notebooks, taken from a number of psychology and psycho-physiognomy texts in the early 1930s, but is also explored and expanded in his fiction and drama. This paper investigates Beckett’s fascination with the limits of “cerebral consciousness” and the brain’s failure to consciously perceive certain bodily modifications especially when processing emotion. Like Antonio Damasio’s definition of emotion as essentially the bodily modifications that include (...) chemical changes, Beckett often exploits the idea of emotion as sorely a bodily phenomenon by creating characters who are unable to consciously perceive and process their emotion. For example, when talking about his own weeping, the narrator of The Unnamable attributes the tears to the malfunctioning of the brain, “liquefied brain”, denying, displacing or making physical the feeling of sadness. By examining the ways in which Beckett emphasizes a somatic dimension of emotion and its relation to the brain function and perception in his writing, this paper reveals how he explores the idea of the self and extends the idea to what he calls the “impenetrable self” that cannot be consciously recognized. I argue that if, for Joseph LeDoux, the “notion of synapses as points of communication between cells is […] essential to our efforts to understand who we are in terms of brain mechanisms”, for Beckett to expose such unconscious biological mechanisms and “gaps” becomes his own artistic challenge. (shrink)

In July 2021, a series of gruesome videos exposed a case of brutal torture perpetrated by a guru or leader of the trans feminine hijra community in eastern India. This guru was allegedly of a Bangladeshi Muslim background, and various community members used the case as an alibi to target hijras of such national and religious origin, sometimes even demanding their expulsion from India. This phenomenon paralleled increasing affiliations between certain sections of trans/hijra communities and the Hindu Right. This article (...) situates this case within the broader rise of queer and trans Hindutva or Hindu nationalism and locates it as indicative of Hindutva’s expansion to its erstwhile ‘elsewheres’: areas outside its traditional strongholds such as eastern India and communities such as hijras who are known for their mixed religious practices and have been historically stigmatised by Hindu society. However, the article also analyses the case to show how hijras and related communities evidence contingently wavering political alliances and complex dynamics of intra-community power and resistance that remain irreducible to typical equations of Hindu right-wing politics. Queer/trans Hindutva might become disrupted by its potential constituents themselves, showing how Hindutva’s ‘elsewheres’ trouble its assimilationist capacities. (shrink)

A major requirement for humans is a breathable atmosphere. In microgravity, despite environmental life support systems regulating air exchange, astronauts complain about air quality, with elevated CO2-levels resulting in detrimental health and performance effects. We extend extant accounts of human respiration to include the role of gravity and buoyancy. Using computational fluid dynamics, we demonstrate that the absence of biothermal convection in microgravity reduces airflow around the human body. This impairs gas exchange by creating an environmental breathing deadspace in front (...) of the face, leading to significant CO2-rebreathing, with implications for astronaut health and countermeasures. In 1g, increasing ambient air temperature can also reduce efficient respiratory exchange, resulting in breathing conditions equivalent to those in microgravity, with implications for treating respiratory disease on Earth. (shrink)

Trope metaphysics tries to explain the world and its features in terms of tropes. Tropes as properties are particulars where as properties, universals are multiply-realizable. The theory of tropes has rejected the existence of Universals. The central claim of this paper is that the trope theory offers comparatively a better metaphysical explanation of the world of everyday experiences than the theory of the Universals. This paper argues that trope metaphysics is better in the sense that (a) it is qualitatively more (...) parsimonious, and (b) its account of the world and its properties is more comprehensive than what the theory of universals offers. (shrink)