Le transfert mitochondrial / nucléaire (M/NT) visant à éviter la transmission de maladies mitochondriales graves soulève des enjeux éthiques, juridiques et sociaux (ELS) complexes. En février 2015, le Royaume-Uni est devenu le premier pays au monde à légaliser le M/NT, rendant le débat houleux sur cette technologie encore plus pertinent. Cette revue d’interprétation critique identifie 95 articles pertinents sur les enjeux ELS du M/NT, y compris des articles de recherche originaux, des rapports gouvernementaux ou commandés par le gouvernement, des éditoriaux, (...) des lettres aux éditeurs et des nouvelles de recherche. La revue présente et synthétise les arguments présents dans la littérature quant aux thèmes les plus fréquemment soulevés: terminologie; identité, relations et parentalité; dommage potentiel; autonomie reproductive; alternatives disponibles; consentement; impact sur des groupes d’intérêt spécifiques; ressources; « pente glissante »; création, utilisation et destruction des embryons humains; et bienfaisance. La revue conclut en identifiant les enjeux ELS spécifiques au M/NT et en appelant à une recherche de suivi longitudinale clinique et psychosociale afin d’alimenter le futur débat sur les enjeux ELS de preuves empiriques. (shrink)

One of the themes that has been widely addressed in both the implicit learning and statistical learning literatures is that of rule learning. While it is widely agreed that the extraction of regularities from the environment is a fundamental facet of cognition, there is still debate about the nature of rule learning. Rey and colleagues show that the comparison between human and non‐human primates can contribute important insights to this debate.

The connective or can be treated as an inclusive disjunction or else as an exclusive disjunction. Although researchers are aware of this distinction, few have examined the conditions under which each interpretation should be anticipated. Based on linguistic-pragmatic analyses, we assume that interpretations are initially inclusive before either (a) remaining so, or (b) becoming exclusive by way of an implicature ( but not both ). We point to a class of situations that ought to predispose disjunctions to inclusive interpretations and (...) to situations that encourage exclusive interpretations. A disjunction's ultimate interpretation is based on its potential informativeness, where the interpretation of the disjunctive utterance having the smallest number of true conditions is considered most informative. Our investigation leads to five experiments employing arbitrary materials. Among the problems expected to encourage inclusive interpretations are those that present disjunctions in the antecedents of conditionals and in question forms. The best candidates to produce implicatures are those disjunctions that underdetermine an expected conjunctive conclusion, although other disjunctive utterances that are more informative as exclusive are discussed and tested. (shrink)

The Gypsies (a misnomer, derived from an early legend about Egyptian origins) defy the conventional definition of a population: they have no nation-state, speak different languages, belong to many religions and comprise a mosaic of socially and culturally divergent groups separated by strict rules of endogamy. Referred to as “the invisible minority”, the Gypsies have for centuries been ignored by Western medicine, and their genetic heritage has only recently attracted attention. Common origins from a small group of ancestors characterise the (...) 8–10 million European Gypsies as an unusual trans-national founder population, whose exodus from India played the role of a profound demographic bottleneck. Social and economic pressures within Europe led to gradual fragmentation, generating multiple genetically differentiated subisolates. The string of population bottlenecks and founder effects have shaped a unique genetic profile, whose potential for genetic research can be met only by study designs that acknowledge cultural tradition and self-identity. BioEssays 27:1084–1094, 2005. © 2005 Wiley Periodicals, Inc. (shrink)

Good Simulation Practice implies that a computational model considered for a simulation task has also been developed according to good practice.

The need for a framework to justify that a model has sufficient credibility to be used as a basis for internal or external (typically regulatory) decision-making is a primary concern when using modelling and simulation (M&S) in healthcare. This chapter reviews published standards on verification, validation, and uncertainty quantification (VVUQ) as well as regulatory guidance that can be used to establish model credibility in this context, providing a potential starting point for a globally harmonised model credibility framework.

All quantum-physical and cosmological causal/non-causal dilemmas have superluminally causal solutions if existents are processual by extension-change impact-transfer. Fixing the extent of applicability of mathematics to physics demonstrates Universal Causality for cosmogenetic theories. Whether the cosmos is of finite or infinite content, the Gravitational Coalescence Paradox in cosmogenetic theories yields a philosophical cosmology of infinite-eternal continuous creation: specifically, the Gravitational Coalescence Cosmology.

There has been much written of late on the topic of panentheism. Dissatisfied with many contemporary descriptions of “panentheism” and the related “pantheism,” which we feel arise out of theistic presuppositions, we produce our own definition of sorts, rooted in and paying respect to the term’s etymology and the concept’s roots in Indian religion and western philosophy. Furthermore, we consider and comment on the arguments and comments concerning panentheism’s definition and plausibility put forth by Göcke, Mullins, and Nickel.

Cicero's philosophical works introduced Latin audiences to the ideas of the Stoics, Epicureans and other schools and figures of the post-Aristotelian period, thus influencing the transmission of those ideas through later history. While Cicero's value as documentary evidence for the Hellenistic schools is unquestioned, Cicero: The Philosophy of a Roman Sceptic explores his writings as works of philosophy that do more than simply synthesize the thought of others, but instead offer a unique viewpoint of their own. In this volume Raphael (...) Woolf describes and evaluates Cicero's philosophical achievements, paying particular attention to his relation to those philosophers he draws upon in his works, his Romanizing of Greek philosophy, and his own sceptical and dialectical outlook. The volume aims, using the best tools of philosophical, philological and historical analysis, to do Cicero justice as a distinctive philosophical voice. Situating Cicero's work in its historical and political context, this volume provides a detailed analysis of the thought of one of the finest orators and writers of the Roman period. Written in an accessible and engaging style, Cicero: The Philosophy of a Roman Sceptic is a key resource for those interested in Cicero's role in shaping Classical philosophy. (shrink)

The aim of this paper is to offer a Henrian interpretation of the debate between Sartre and Merleau-Ponty concerning the place of the imaginary in the perceptive life. The hypothesis is that in Sartre, Merleau-Ponty and Henry, the role of the imaginary in the original affective experience which the perceptive life has of its own intrinsic vulnerability can be investigated on three levels: the articulation between the absolute dimension and the egological dimension of consciousness in Sartre, the genesis of perception (...) in the body in Merleau-Ponty, and the immanent adherence of the perceptive act to the radical suffering of its own force in Henry. From each of these three levels, the paper shows that without an imaginary in charge of bringing it back constantly to the experience of its own original vulnerability, the perceptive life is bound to lose the aff ective density of its relation to the perceived, and therefore is bound to become disincarnate. (shrink)

Contrary to Mendel, who introduced hybridization as a methodology for the study of selected discrete traits, de Vries conceived of organisms to be composed of discrete traits. This introduced into genetic research the dialectics of reductive analysis of genes as instrumental variables versus that of genes as the material atoms of heredity. The latter conception gained support with the analysis of mutations and eventually with high resolution analysis at the genetic and biochemical levels, as achieved in fungi and later in (...) bacteria and their viruses. Attempts to reduce "classical" genetics to "molecular" genetics turned out to be futile. However, this did not necessarily imply that these were two distinct theoretical approaches. On the contrary, it is argued that molecular genetics is an extension of phenomenological deduction, rather than being induction from molecular (DNA) causes to effects. Although conceptually systems direct development, methodologically individual inputs must be studied. (shrink)

This study discusses second generation scientific ontological categories: substance-tradition from Aristotle to Kant, Gödel, Quine, Strawson and others, Being-thinking from Aristotle to Heidegger, and system-building from Plato to Whitehead. The resulting ontology is termed Einaic Ontology for maximalist, mutually collusive, categorial reasons.

Au seuil de la modernité, deux débats dessinent le cadre d'une nouvelle conception de l'esprit, dans son rapport au monde. Ainsi, le tracé du partage entre intériorité et extériorité est au coeur des différends qui opposent René Descartes à Thomas Hobbes d'abord, John Locke à Gottfried Wilhelm Leibniz ensuite. Dans leurs oeuvres, l'intériorité fonctionne comme modèle pour concevoir l'esprit, en tant qu'il contient des idées des choses extérieures. Mais ce motif commun recouvre deux problèmes croisés. Quel est le rapport entre (...) intériorité et matérialité? L'intériorité est-elle subordonné à l'extériorité?"--Page 4 of cover. (shrink)

Many authors claim that being conscious constitutively involves being self-conscious, or conscious of oneself. This claim appears to be threatened by reports of `selfless' episodes, or conscious episodes lacking self-consciousness, recently described in a number of pathological and nonpathological conditions. However, the credibility of these reports has in turn been challenged on the following grounds: remembering and reporting a past conscious episode as an episode that one went through is only possible if one was conscious of oneself while undergoing it. (...) Call this the Memory Challenge. This paper argues that the Memory Challenge fails to undermine the credibility to reports of selfless episodes, because it rests on problematic assumptions about episodic memory. The paper further argues that we should distinguish between several kinds of self-representation that may be involved in the process of episodic remembering, and that once we do so, it is no longer mysterious how one could accurately remember and report a selfless episode as an episode that one went through. Thus, we should take reports of this kind seriously, and view them as credible counter-examples to the claim that consciousness constitutively involves self-consciousness. (shrink)

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Kyle Stanford has recently given substance to the problem of unconceived alternatives, which challenges the reliability of inference to the best explanation (IBE) in remote domains of nature. Conjoined with the view that IBE is the central inferential tool at our disposal in investigating these domains, the problem of unconceived alternatives leads to scientific anti-realism. We argue that, at least within the biological community, scientists are now and have long been aware of the dangers of IBE. We re-analyse the nineteenth-century (...) study of inheritance and development (Stanford’s case study) and extend it into the twentieth century, focusing in particular on both classical Mendelian genetics and the studies by Avery et al. on the chemical nature of the hereditary substance. Our extended case studies show the preference of the biological community for a different methodological standard: the vera causa ideal, which requires that purported causes be shown on non-explanatory grounds to exist and be competent to produce their effects. On this basis, we defend a prospective realism about the biological sciences. 1 Introduction2 Stanford on Unconceived Alternatives3 Pangenesis: A Re-analysis4 The Vera Causa Ideal I: Negative Aspect5 Rendering Heredity Accessible6 The Vera Causa Ideal II: Positive Aspect7 Implications for Scientific Realism8 Conclusion. (shrink)

D. D. Raphael examines the moral philosophy of Adam Smith (1723-90), best known for his famous work on economics, The Wealth of Nations, and shows that his thought still has much to offer philosophers today. Raphael gives particular attention to Smith's original theory of conscience, with its emphasis on the role of 'sympathy' (shared feelings).

According to the "confrontation model," integrated history and philosophy of science operates like an empirical science. It tests philosophical accounts of science against historical case studies much like other sciences test theory against data. However, the confrontation model's critics object that historical facts can neither support generalizations nor genuinely test philosophical theories. Here I argue that most of the model's defects trace to its usual framing in terms of two problematic accounts of empirical inference: the hypothetico-deductive method and enumerative induction. (...) This framing can be taken to suggest an unprofitable one-off confrontation between particular historical facts and general philosophical theories. I outline more recent accounts of empirical inquiry, which describe an iterative back-and-forth movement between concrete empirical exemplars to their abstract descriptions. Reframed along similar lines, the confrontation model continues to offer both conceptual insight and practical guidance for a naturalized philosophy of science. (shrink)

In order to better understand the conditions of the twenty-first century Raphael Sassower and Louis Cicotello revisit the twentieth century in Political Blind Spots: Reading the Ideology of Images. Sassower and Cicotello revisit some of the most significant periods in art and politics in the twentieth century paying close attention to the relationship between aesthetics and politics.