Melatonin, the neuro‐hormone synthesized during the night, has recently seen an unexpected extension of its functional implications toward type 2 diabetes development, visual functions, sleep disturbances, and depression. Transgenic mouse models were instrumental for the establishment of the link between melatonin and these major human diseases. Most of the actions of melatonin are mediated by two types of G protein‐coupled receptors, named MT1 and MT2, which are expressed in many different organs and tissues. Understanding the pharmacology and function of mouse (...) MT1 and MT2 receptors, including MT1/MT2 heteromers, will be of crucial importance to evaluate the relevance of these mouse models for future therapeutic developments. This review will critically discuss these aspects, and give some perspectives including the generation of new mouse models. (shrink)

ABSTRACTThis paper addresses the problem of opaque sweetening and argues that one should use stochastic dominance in comparing lotteries even when dealing with incomplete orderings that allow for non-comparable outcomes.

Objectives Medical futility at the end of life is a growing challenge to medicine. The goals of the authors were to elucidate how clinicians define futility, when they perceive life-sustaining treatment (LST) to be futile, how they communicate this situation and why LST is sometimes continued despite being recognised as futile. Methods The authors reviewed ethics case consultation protocols and conducted semi-structured interviews with 18 physicians and 11 nurses from adult intensive and palliative care units at a tertiary hospital in (...) Germany. The transcripts were subjected to qualitative content analysis. Results Futility was identified in the majority of case consultations. Interviewees associated futility with the failure to achieve goals of care that offer a benefit to the patient's quality of life and are proportionate to the risks, harms and costs. Prototypic examples mentioned are situations of irreversible dependence on LST, advanced metastatic malignancies and extensive brain injury. Participants agreed that futility should be assessed by physicians after consultation with the care team. Intensivists favoured an indirect and stepwise disclosure of the prognosis. Palliative care clinicians focused on a candid and empathetic information strategy. The reasons for continuing futile LST are primarily emotional, such as guilt, grief, fear of legal consequences and concerns about the family's reaction. Other obstacles are organisational routines, insufficient legal and palliative knowledge and treatment requests by patients or families. Conclusion Managing futility could be improved by communication training, knowledge transfer, organisational improvements and emotional and ethical support systems. The authors propose an algorithm for end-of-life decision making focusing on goals of treatment. (shrink)

Inductive Metaphysics combines an anti-aprioristic emphasis on an empirical and scientific basis for metaphysics with an insistence on a specifically philosophical abductive theory-building. Since the latter specifically philosophical work is not empirical itself, it may in a liberal sense be called apriori. This paper highlights this apriori dimension within IM by a case study on Structuralism, the view that fundamental reality consists of a network of relations, which a number of philosophers consider to be suggested by modern physics. Focussing on (...) Dasgupta’s algebraic Generalism, the author argues that Structuralism suffers from a severe entailment problem, because the relations-spanning apparatus must stand for metaphysically fundamental forms. Schaffer’s contention that there are no entailment problems is rejected. Advocates of IM are well advised to take seriously their own insistence on metaphysical abduction and not to one-sidedly emphasise the empirical input: the elaboration of exact metaphysical theories and the apriori evaluation of their inherent tenability is a constituent of IM no less important than the consideration of scientific input. More traditional ways of metaphysical reasoning inevitably survive as an essential dimension within IM. (shrink)

Name der Zeitschrift: Neue Zeitschrift für Systematische Theologie und Religionsphilosophie Jahrgang: 61 Heft: 1 Seiten: 1-15.

There are few commonalities between intraspecific aggression and predation and few convincing arguments for the conceptualisation of blood and pain as rewards for predation. Not cruelty, but ritualised intraspecific aggression is the predominant mechanism of accretion of social power and this, not cruelty, is what bestows reproductive advantages. Enjoyment of media cruelty is not reinforced by “emotional circuits” adapted to predation, but represents transient relief from culturally determined inhibition of aggression.

ZusammenfassungDie protestantische Polemik steht beim Thema fides implicita sofort im Raum. Doch was bedeutet fides implicita eigentlich? Welche Verstehensmuster haben sich herausgebildet? Der Versuch der Rekonstruktion des Begriffs, der auch seine entstehungsgeschichtlichen Funktionen analysiert, wird nach Ablösung aus der katholischen Ekklesiologie das evangelische Verständnis freilegen. Das Wahrheitsmoment der fides implicita liegt im Gottvertrauen, das eine Kenntnis immer schon impliziert, sei es intuitiv oder antizipativ und dabei intellektuell noch so begrenzt: Es ist einerseits noch nicht erkennend, andererseits Erkennendes bereits implizierend. Im (...) Glauben ist noch diejenige Erkenntnisweise wirksam, die unmittelbar und ohne den Umweg folgernden Denkens zur Gewissheit kommt. Darauf verweist die fides implicita.SummaryThe protestant polemic is vivid when it comes to fides implicita. But what does the concept really mean? What sorts of patterns of understanding have been developed in the past? The attempt at reconstructing the term will include an analysis of the specific functions that fides implicita have had in history. Taking it out of the context of catholic eccelsiology allows for a protestant understanding, namely that fides implicita is about trust in God, which already implies knowledge per se, whether it is intuitive or anticipatory or even intellectually limited: It is not yet knowing, on the one hand, and implies already knowledge, on the other hand. In faith we find a very special perception of knowledge that arrives at certainty directly rather than discursively. This is the challenge of fides implicita. (shrink)

This paper assesses the role of the Refutation of Idealism within the Critique of Pure Reason, as well as its relation to the treatment of idealism in the First Edition and to transcendental idealism more generally. It is argued that the Refutation is consistent with the Fourth Paralogism and that it can be considered as an extension of the Transcendental Deduction. While the Deduction, considered on its own, constitutes a 'regressive argument', the Refutation allows us to turn the Transcendental Analytic (...) into a 'progressive argument' that proceeds by the synthetic method. (shrink)

This paper provides an account of Kant's categories of freedom, explaining how they fit together and what role they are supposed to play. My interpretation places particular emphasis on the structural features that the table of the categories of freedom shares with the table of judgements and the table of categories laid out by Kant in the Critique of Pure Reason. In this way we can identify two interpretative constraints, namely (i) that the categories falling under each heading must form (...) a synthetic unity whereby the third one derives from the combination of the other two. and (ii) that the first two categories falling under each heading must be morally undetermined and sensibly conditioned, while the third category is sensibly unconditioned and determined only by the moral law. (shrink)

Der vorliegende Beitrag soll das Verständnis von Freuds Traumtheorie erleichtern. Die vorgestellte neue Perspektive basiert auf dem fünften Kapitel von Freuds »Abriß der Psychoanalyse« (1940a). Dieses Kapitel enthält eine kompakte Zusammenfassung von Freuds Traumtheorie unter Anwendung des strukturellen Gesichtspunktes. Die Autoren schlagen vor, dieses Kapitel als eine Art Lesehilfe für die Lektüre der »Traumdeutung« zu verwenden, was durch einige Absätze aus deren siebtem Kapitel illustriert wird. Auf diese Weise soll deutlich gemacht werden, dass »Die Traumdeutung« nicht umgeschrieben werden muss, um (...) den strukturellen Gesichtspunkt zu integrieren. Vielmehr können der topographische und der strukturelle Gesichtspunkt elegant zusammengeführt werden. Anschließend wird die überdachte Lesart mit einigen früheren Publikationen aus der psychoanalytischen Literatur verglichen, und es werden Implikationen für die klinische Anwendung der Traumtheorie diskutiert. Abschließend wird die neue Lesart von Freuds Traumtheorie in zehn Punkten zusammengefasst. (shrink)

Given the many marvelous things animals can do and moreover the success we have in employing the intentional stance towards animals, it seems to be almost unthinkable to say that animals could not act at all. Nonetheless, this is exactly what I argue for. I claim that strictly speaking there is no animal action, only behaviour. I defend this claim in three steps. Firstly, I recapitulate some of the weighty grounds that speak in favour of animal agency. Secondly, I explain (...) why I still doubt that animals act. The argument is that the account of agency that I take to be the most attractive one entails that animals can't act. Since this account of agency is non-standard, I spend the bulk of the paper with providing a sketch of what, according to it, actions are. Finally, I explain why it is still so natural and promising to regard animals as agents, although in fact they aren't. As one might put it: of course they act, only strictly speaking they don't. (shrink)

Gegenstand des Bandes ist eine Profilierung der Kulturphilosophie mit dem Ziel ihrer notigen Selbstbehauptung gegenuber einem gegenwartigen Naturalismus. Ein zentrales Ratsel der Gegenwartsphilosophie ist das Verhaltnis unseres Bewusstseins, der Perspektive der ersten Person machtig und Urheber der Kultur zu sein, zu den Erkenntnissen der Kognitions- sowie der Evolutionswissenschaften seit Darwin. In diesen scheint von der Natur her auf die Kultur ein neues Licht zu fallen. Dies ist ebenso faszinierend wie interessant. Es ist aber auch eine Herausforderung: Der Begriff der "Welt" (...) wird naturwissenschaftlich praokkupiert, Extrapolationen ins Ontologische wie die "kausale Geschlossenheit der Welt" breiten sich auf Kosten fruherer, starker zuruckgenommener Erkenntnis- und Wissenschaftstheorien aus. Wie steht es demgegenuber mit den Beitragen von Kulturphilosophie und Kulturwissenschaften / Geisteswissenschaften? Deutlich wird in den Beitragen im Anschluss an Dilthey, Cassirer, Simmel und weitere Autoren: Die Notwendigkeit und der Eigencharakter kultureller Arbeit mussen offentlich wie in den Wissenschaften wieder bewusst werden. Mit Beitragen von Katharina Bauer, Jorn Bohr, Gunter Dux, Ralf Glitza, Kinga Golus, Julia Gruevska, Ralph Kohnen, Gudrun Kuhne-Bertram, Hans-Ulrich Lessing, Kevin Liggieri, Ernst Wolfgang Orth, Annika Schlitte, Gunter Scholtz und Rene Torkler. (shrink)

School as counter-public" is the hermeneutic key with which Ralf Koerrenz interprets the school model of the Jena Plan. Similar to the Dalton-Plan or the Winnetka-Plan, the Jena Plan is one of the most important concepts of alternative schools developed in the first half of the 20th century as part of the international movement for alternative education, the?World Education Fellowship?. 0Peter Petersen's "Jena Plan" concept must be understood from his educational philosophical foundations. The didactic levels of action at school (...) (teaching, learning) as well as the reflection of theory in pedagogical practice are made understandable by "school as a counter-public". Not least with a view to the today's Jena Plan schools, the question is asked for a context-independent core of what makes a school a Jena Plan school. The opportunities and ambivalences of the model thus become equally visible. (shrink)

Inhalt Einfuhrung - Staat im Wandel. Rudiger Voigt zum 65. Geburtstag I. Konzeptualisierung und Systematisierung von Staatswandel Ralf Walkenhaus: Entwicklungslinien moderner Staatlichkeit.

Viele Philosophen sind überzeugt, daß unser Wahrnehmungsbewußtsein phänomenale Charakteristika aufweist, die sich in ein physikalistisches Weltbild entweder gar nicht oder nur mit Schwierigkeiten integrieren lassen. Aber wie ist überhaupt unsere reflexive Einsicht erklärbar, daß unser Bewußtsein solche Charakteristika aufweist? An prominenten Beispielen läßt sich zeigen, daß dazu keineswegs die Annahme ausreicht, sie seien intrinsische Bestimmungen unserer Bewußtseinszustände. Vielmehr ist eine radikalere internalistische Konzeption der Inhalte unseres Bewußtseins erforderlich, wie sie Hector-Neri Castañeda entwickelt hat. Eine kritische Untersuchung von Castañedas Ontologie und (...) Wahrnehmungstheorie liefert die Theorieelemente, mit denen die phänomenologische Reflexion erklärbar wird. (shrink)

Putnam’s internal realism implies a form of conceptual relativity with respect to ontology. There can be different descriptions of the world which are based on distinct ontologies. It has been argued that this relativity forecloses any possibility of unifying our knowledge and can even lead to inconsistency. If this is true, internal realism should be abandoned because it is compatible with non-rational positions. We will argue that these objections can be dismissed if truth as idealized warranted assertibility is understood as (...) stability of a belief state under new evidence. This view of truth is still compatible with the existence of distinct belief states expressing different views on the world. This understanding of the notion of truth is a consequence of interpreting both our cognitive activities and the notion of meaning dynamically. The meaning of a sentence is no longer given in terms of (static) truth conditions but as a relation between belief sets, that is, as a kind of information change potential. (shrink)

Microinsurance is the provision of insurance services to the poor, usually in developing countries. One of the key criteria of poverty is vulnerability even to minor events. In such cases, even micro coverage can make a major difference, yet still be funded by an affordable contribution by the insured. Like any kind of insurance, microinsurance can cover different risks to life, health, farming, property among other things. Our paper sketches how one could address and develop microinsurance business ethics. First, we (...) introduce microinsurance to the business ethics community and business ethics to the microinsurance community. Our draft of microinsurance ethics is then developed from two angles: as a holistic understanding of ideals and possible ethical conflicts in key stakeholder relationships and by distinguishing eight challenges when targeting the poor and when marketing microinsurance. As an open ending, the article suggests a three-stage action research design focusing on how microinsurance could (and should) internalize ethics, respecting rather than neglecting national- and local-cultural conditions. (shrink)

McMahan and Savulescu have put forward a two-tier view that combines person-affecting and impersonal considerations and that is supposed to both favour gene editing over genetic selection and favour saving an existing person over creating a new person. This note shows that a contrastive construal of person-affecting reasons does favour saving over creating, but fails to favour gene editing over genetic selection, whereas a non-contrastive construal does the reverse. Moreover, it shows that both approaches lead to dynamic inconsistencies and to (...) sub-optimal outcomes being chosen. (shrink)

This paper establishes that the occasional identity relation and the contingent identity relation are both non-transitive and as such are not properly classified as identity relations. This is achieved by appealing to cases where multiple fissions and fusions occur simultaneously. These cases show that the contingent and occasional identity relations do not even satisfy the time-indexed and world-indexed versions of the transitivity requirement and hence are non-transitive relations.

This paper develops co-ordinated multiple-domain supervenience relations to model determination and dependence relations between complex entities and their constituents by appealing to R-related pairs and by making use of associated isomorphisms. Supervenience relations are devised for order-sensitive and repetition-sensitive mereologies, for mereological systems that make room for many-many composition relations, as well as for hierarchical mereologies that incorporate compositional and hylomorphic structure. Finally, mappings are provided for theories that consider wholes to be prior to their parts.

Let L[E] be an iterable tame extender model. We analyze to which extent L[E] knows fragments of its own iteration strategy. Specifically, we prove that inside L[E], for every cardinal K which is not a limit of Woodin cardinals there is some cutpoint t K > a>ω1 are cardinals, then ◊$_{K.\lambda }^* $ holds true, and if in addition λ is regular, then ◊$_{K.\lambda }^* $ holds true.

First published in 1992. Routledge is an imprint of Taylor & Francis, an informa company.

In the three target articles, Ellen Fox et al. present data from their seminal study on ethics consultation in US general hospitals (Fox, Danis, et al. 2022, Fox and Duke 2022, Fox, Tarzian, et al....

Coall & Hertwig (C&H) suggest that, because grandparental investments do not impact on child mortality in low-risk societies, fitness effects are not plausible any more. We found that grandparental investments could very well alleviate contemporary constraints on fertility. Cultural factors may influence both the occurrence and impact of grandparental investments.