Melatonin, the neuro‐hormone synthesized during the night, has recently seen an unexpected extension of its functional implications toward type 2 diabetes development, visual functions, sleep disturbances, and depression. Transgenic mouse models were instrumental for the establishment of the link between melatonin and these major human diseases. Most of the actions of melatonin are mediated by two types of G protein‐coupled receptors, named MT1 and MT2, which are expressed in many different organs and tissues. Understanding the pharmacology and function of mouse (...) MT1 and MT2 receptors, including MT1/MT2 heteromers, will be of crucial importance to evaluate the relevance of these mouse models for future therapeutic developments. This review will critically discuss these aspects, and give some perspectives including the generation of new mouse models. (shrink)

There are few commonalities between intraspecific aggression and predation and few convincing arguments for the conceptualisation of blood and pain as rewards for predation. Not cruelty, but ritualised intraspecific aggression is the predominant mechanism of accretion of social power and this, not cruelty, is what bestows reproductive advantages. Enjoyment of media cruelty is not reinforced by “emotional circuits” adapted to predation, but represents transient relief from culturally determined inhibition of aggression.

Name der Zeitschrift: Neue Zeitschrift für Systematische Theologie und Religionsphilosophie Jahrgang: 61 Heft: 1 Seiten: 1-15.

Inductive Metaphysics combines an anti-aprioristic emphasis on an empirical and scientific basis for metaphysics with an insistence on a specifically philosophical abductive theory-building. Since the latter specifically philosophical work is not empirical itself, it may in a liberal sense be called apriori. This paper highlights this apriori dimension within IM by a case study on Structuralism, the view that fundamental reality consists of a network of relations, which a number of philosophers consider to be suggested by modern physics. Focussing on (...) Dasgupta’s algebraic Generalism, the author argues that Structuralism suffers from a severe entailment problem, because the relations-spanning apparatus must stand for metaphysically fundamental forms. Schaffer’s contention that there are no entailment problems is rejected. Advocates of IM are well advised to take seriously their own insistence on metaphysical abduction and not to one-sidedly emphasise the empirical input: the elaboration of exact metaphysical theories and the apriori evaluation of their inherent tenability is a constituent of IM no less important than the consideration of scientific input. More traditional ways of metaphysical reasoning inevitably survive as an essential dimension within IM. (shrink)

This paper assesses the role of the Refutation of Idealism within the Critique of Pure Reason, as well as its relation to the treatment of idealism in the First Edition and to transcendental idealism more generally. It is argued that the Refutation is consistent with the Fourth Paralogism and that it can be considered as an extension of the Transcendental Deduction. While the Deduction, considered on its own, constitutes a 'regressive argument', the Refutation allows us to turn the Transcendental Analytic (...) into a 'progressive argument' that proceeds by the synthetic method. (shrink)

This paper establishes that the occasional identity relation and the contingent identity relation are both non-transitive and as such are not properly classified as identity relations. This is achieved by appealing to cases where multiple fissions and fusions occur simultaneously. These cases show that the contingent and occasional identity relations do not even satisfy the time-indexed and world-indexed versions of the transitivity requirement and hence are non-transitive relations.

Nog nooit waren we met zoveel mensen. En nog nooit leefden we met zovelen in welvaart, vrede en een goede gezondheid. Toch denken we naargeestig over onszelf. Wij, mensen, veroorzaken klimaatverandering, beroven de aarde van haar grondstoffen en zetten de biodiversiteit onder druk. "De aarde heeft kanker en die kanker is de mens", meende de Club van Rome. Daarmee doen we onszelf tekort. Wij, mensen, maken de aarde ook veel rijker, kleurrijker en interessanter. We bouwen steden, componeren muziek en zetten (...) ons in voor een duurzame toekomst. In deze meeslepende vertelling reis je met Ralf Bodelier naar de filosofische wortels van het denken over de mens. En hij neemt je mee op een spannende ontdekkingstocht door het Ruhrgebied, Afrikaanse slums en het Midden-Oosten. Bodelier pleit voor een herwaardering van de mens als schepper, bouwer en beschermer. Want met een optimistisch en veelkleurig mensbeeld kunnen we de toekomst beter aan."--Page 4 of cover. (shrink)

Viele Philosophen sind überzeugt, daß unser Wahrnehmungsbewußtsein phänomenale Charakteristika aufweist, die sich in ein physikalistisches Weltbild entweder gar nicht oder nur mit Schwierigkeiten integrieren lassen. Aber wie ist überhaupt unsere reflexive Einsicht erklärbar, daß unser Bewußtsein solche Charakteristika aufweist? An prominenten Beispielen läßt sich zeigen, daß dazu keineswegs die Annahme ausreicht, sie seien intrinsische Bestimmungen unserer Bewußtseinszustände. Vielmehr ist eine radikalere internalistische Konzeption der Inhalte unseres Bewußtseins erforderlich, wie sie Hector-Neri Castañeda entwickelt hat. Eine kritische Untersuchung von Castañedas Ontologie und (...) Wahrnehmungstheorie liefert die Theorieelemente, mit denen die phänomenologische Reflexion erklärbar wird. (shrink)

Let N be a transitive model of ZFC such that ωN ⊂ N and P(R) ⊂ N. Assume that both V and N satisfy "the core model K exists." Then KN is an iterate of K. i.e., there exists an iteration tree J on K such that J has successor length and $\mathit{M}_{\infty}^{\mathit{J}}=K^{N}$. Moreover, if there exists an elementary embedding π: V → N then the iteration map associated to the main branch of J equals π ↾ K. (This answers (...) a question of W. H. Woodin, M. Gitik, and others.) The hypothesis that P(R) ⊂ N is not needed if there does not exist a transitive model of ZFC with infinitely many Woodin cardinals. (shrink)

This paper provides an account of Kant's categories of freedom, explaining how they fit together and what role they are supposed to play. My interpretation places particular emphasis on the structural features that the table of the categories of freedom shares with the table of judgements and the table of categories laid out by Kant in the Critique of Pure Reason. In this way we can identify two interpretative constraints, namely (i) that the categories falling under each heading must form (...) a synthetic unity whereby the third one derives from the combination of the other two. and (ii) that the first two categories falling under each heading must be morally undetermined and sensibly conditioned, while the third category is sensibly unconditioned and determined only by the moral law. (shrink)

Given the many marvelous things animals can do and moreover the success we have in employing the intentional stance towards animals, it seems to be almost unthinkable to say that animals could not act at all. Nonetheless, this is exactly what I argue for. I claim that strictly speaking there is no animal action, only behaviour. I defend this claim in three steps. Firstly, I recapitulate some of the weighty grounds that speak in favour of animal agency. Secondly, I explain (...) why I still doubt that animals act. The argument is that the account of agency that I take to be the most attractive one entails that animals can't act. Since this account of agency is non-standard, I spend the bulk of the paper with providing a sketch of what, according to it, actions are. Finally, I explain why it is still so natural and promising to regard animals as agents, although in fact they aren't. As one might put it: of course they act, only strictly speaking they don't. (shrink)

First published in 1992. Routledge is an imprint of Taylor & Francis, an informa company.

Most deontologists find bedrock in the Pauline doctrine that it is morally objectionable to do evil in order that good will come of it. Uncontroversially, this doctrine condemns the killing of an innocent person simply in order to maximize the sum total of happiness. It rules out the conscription of a worker to his or her certain death in order to repair a fault that is interfering with the live broadcast of a World Cup match that a billion spectators have (...) been enjoying. It rules out such sacrifice even if it would maximize the sum total of everyone's happiness. An act utilitarian, by contrast, would require the sacrifice of the one whenever this latter condition obtains, since such a utilitarian is committed to the view that one ought always to act so as to bring about the greatest sum total of happiness. An act utilitarian might, however, consistently hold that a large number of rather insignificant pleasures, such as that which a spectator derives from witnessing men in shorts running around and kicking a ball, is never sufficient to justify the infliction of a great harm on a single individual. 4 He might take such a position without abandoning utilitarianism by denying that the sum total of such minor pleasures could ever be sufficiently great to outweigh the harm of death to the one. Under the inspiration of John Stuart Mill, a utilitarian might draw a more general distinction between serious and trivial harms and pleasures and maintain that no amount of a trivial pleasure could ever amount to a sum of happiness that is greater than the disutility of a serious harm. (shrink)

The present paper investigates the power of proper forcings to change the shape of the universe, in a certain well-defined respect. It turns out that the ranking among large cardinals can be used as a measure for that power. However, in order to establish the final result I had to isolate a new large cardinal concept, which I dubbed “remarkability.” Let us approach the exact formulation of the problem—and of its solution—at a slow pace.Breathtaking developments in the mid 1980s found (...) one of its culminations in the theorem, due to Martin, Steel, and Woodin, that the existence of infinitely many Woodin cardinals with a measurable cardinal above them all implies that AD, the axiom of determinacy, holds in the least inner model containing all the reals, L. One of the nice things about AD is that the theory ZF + AD + V = L appears as a choiceless “completion” of ZF in that any interesting question seems to find an at least attractive answer in that theory. Beyond that, AD is very canonical as may be illustrated as follows.Let us say that L is absolute for set-sized forcings if for all posets P ∈ V, for all formulae ϕ, and for all ∈ ℝ do we have thatwhere is a name for the set of reals in the extension. (shrink)

Putnam’s internal realism implies a form of conceptual relativity with respect to ontology. There can be different descriptions of the world which are based on distinct ontologies. It has been argued that this relativity forecloses any possibility of unifying our knowledge and can even lead to inconsistency. If this is true, internal realism should be abandoned because it is compatible with non-rational positions. We will argue that these objections can be dismissed if truth as idealized warranted assertibility is understood as (...) stability of a belief state under new evidence. This view of truth is still compatible with the existence of distinct belief states expressing different views on the world. This understanding of the notion of truth is a consequence of interpreting both our cognitive activities and the notion of meaning dynamically. The meaning of a sentence is no longer given in terms of (static) truth conditions but as a relation between belief sets, that is, as a kind of information change potential. (shrink)

This paper develops co-ordinated multiple-domain supervenience relations to model determination and dependence relations between complex entities and their constituents by appealing to R-related pairs and by making use of associated isomorphisms. Supervenience relations are devised for order-sensitive and repetition-sensitive mereologies, for mereological systems that make room for many-many composition relations, as well as for hierarchical mereologies that incorporate compositional and hylomorphic structure. Finally, mappings are provided for theories that consider wholes to be prior to their parts.

This paper provides an account of the asymmetry in population ethics. The first half of the asymmetry is explicated by means of a person-affecting view, whereas the second half is established by means of a structural consistency constraint. This account can be integrated into a general theory that can handle (i) cases where there are externalities in that members of the original distribution are positively or negatively affected by bringing the miserable life into existence, (ii) cases in which one is (...) concerned not only with bringing individual persons into existence but also groups of people, and (iii) situations in which it is uncertain whether an action will result in the addition of lives that are worth not living. (shrink)

This paper argues that impersonal versions of utilitarianism involve an objectionable axiology that does not take personal good seriously. Rather than attributing ethical significance to personal good, they only consider it to be ethically relevant. As a result, they end up sub-ordinating and sacrificing personal good for the sake of impersonal good and thereby treat persons as mere containers of impersonal good. This gives rise to particularly troubling implications in variable-population cases. The paper then evaluates the prospects for person-affecting versions (...) of utilitarianism. It argues that same-number person-affecting utilitarianism is the only version of utilitarianism that neither involves an objectionable axiology nor requires problematic metaphysical commitments. (shrink)

Gegenstand des Bandes ist eine Profilierung der Kulturphilosophie mit dem Ziel ihrer notigen Selbstbehauptung gegenuber einem gegenwartigen Naturalismus. Ein zentrales Ratsel der Gegenwartsphilosophie ist das Verhaltnis unseres Bewusstseins, der Perspektive der ersten Person machtig und Urheber der Kultur zu sein, zu den Erkenntnissen der Kognitions- sowie der Evolutionswissenschaften seit Darwin. In diesen scheint von der Natur her auf die Kultur ein neues Licht zu fallen. Dies ist ebenso faszinierend wie interessant. Es ist aber auch eine Herausforderung: Der Begriff der "Welt" (...) wird naturwissenschaftlich praokkupiert, Extrapolationen ins Ontologische wie die "kausale Geschlossenheit der Welt" breiten sich auf Kosten fruherer, starker zuruckgenommener Erkenntnis- und Wissenschaftstheorien aus. Wie steht es demgegenuber mit den Beitragen von Kulturphilosophie und Kulturwissenschaften / Geisteswissenschaften? Deutlich wird in den Beitragen im Anschluss an Dilthey, Cassirer, Simmel und weitere Autoren: Die Notwendigkeit und der Eigencharakter kultureller Arbeit mussen offentlich wie in den Wissenschaften wieder bewusst werden. Mit Beitragen von Katharina Bauer, Jorn Bohr, Gunter Dux, Ralf Glitza, Kinga Golus, Julia Gruevska, Ralph Kohnen, Gudrun Kuhne-Bertram, Hans-Ulrich Lessing, Kevin Liggieri, Ernst Wolfgang Orth, Annika Schlitte, Gunter Scholtz und Rene Torkler. (shrink)

Objectives Medical futility at the end of life is a growing challenge to medicine. The goals of the authors were to elucidate how clinicians define futility, when they perceive life-sustaining treatment (LST) to be futile, how they communicate this situation and why LST is sometimes continued despite being recognised as futile. Methods The authors reviewed ethics case consultation protocols and conducted semi-structured interviews with 18 physicians and 11 nurses from adult intensive and palliative care units at a tertiary hospital in (...) Germany. The transcripts were subjected to qualitative content analysis. Results Futility was identified in the majority of case consultations. Interviewees associated futility with the failure to achieve goals of care that offer a benefit to the patient's quality of life and are proportionate to the risks, harms and costs. Prototypic examples mentioned are situations of irreversible dependence on LST, advanced metastatic malignancies and extensive brain injury. Participants agreed that futility should be assessed by physicians after consultation with the care team. Intensivists favoured an indirect and stepwise disclosure of the prognosis. Palliative care clinicians focused on a candid and empathetic information strategy. The reasons for continuing futile LST are primarily emotional, such as guilt, grief, fear of legal consequences and concerns about the family's reaction. Other obstacles are organisational routines, insufficient legal and palliative knowledge and treatment requests by patients or families. Conclusion Managing futility could be improved by communication training, knowledge transfer, organisational improvements and emotional and ethical support systems. The authors propose an algorithm for end-of-life decision making focusing on goals of treatment. (shrink)

Let L[E] be an iterable tame extender model. We analyze to which extent L[E] knows fragments of its own iteration strategy. Specifically, we prove that inside L[E], for every cardinal K which is not a limit of Woodin cardinals there is some cutpoint t K > a>ω1 are cardinals, then ◊$_{K.\lambda }^* $ holds true, and if in addition λ is regular, then ◊$_{K.\lambda }^* $ holds true.

Homology is the similarity between organisms due to common ancestry. Introduced by Richard Owen in 1843 in a paper entitled “Lectures on comparative anatomy and physiology of the invertebrate animals”, the concept of homology predates Darwin's “Origin of Species” and has been very influential throughout the history of evolutionary biology. Although homology is the central concept of all comparative biology and provides a logical basis for it, the definition of the term and the criteria of its application remain controversial. Here, (...) I will discuss homology in the context of the hierarchy of biological organization. I will provide insights gained from an exemplary case study in evolutionary developmental biology that indicates the uncoupling of homology at different levels of biological organization. I argue that continuity and hierarchy are separate but equally important issues of homology. BioEssays 30:653–658, 2008. © 2008 Wiley Periodicals, Inc. (shrink)

School as counter-public" is the hermeneutic key with which Ralf Koerrenz interprets the school model of the Jena Plan. Similar to the Dalton-Plan or the Winnetka-Plan, the Jena Plan is one of the most important concepts of alternative schools developed in the first half of the 20th century as part of the international movement for alternative education, the?World Education Fellowship?. 0Peter Petersen's "Jena Plan" concept must be understood from his educational philosophical foundations. The didactic levels of action at school (...) (teaching, learning) as well as the reflection of theory in pedagogical practice are made understandable by "school as a counter-public". Not least with a view to the today's Jena Plan schools, the question is asked for a context-independent core of what makes a school a Jena Plan school. The opportunities and ambivalences of the model thus become equally visible. (shrink)

Sensationalistic Phenomenalism and Economy of Thought. On Ernst Mach's Concept of Science. Ernst Mach, natural scientist and major precursor of the Vienna Circle, never wants to be a philosopher. Nevertheless his writings are full of valuable hints for a modern theory of human knowledge – with respect to economical, historical and evolutionary aspects. His kind of phenomenalism is sensationalistic, monistic and instrumentalistic. This article deals with some contributions of his approach to actual debates in the general philosophy of science.

Currently, two frameworks of causal reasoning compete: Whereas dependency theories focus on dependencies between causes and effects, dispositional theories model causation as an interaction between agents and patients endowed with intrinsic dispositions. One important finding providing a bridge between these two frameworks is that failures of causes to generate their effects tend to be differentially attributed to agents and patients regardless of their location on either the cause or the effect side. To model different types of error attribution, we augmented (...) a causal Bayes net model with separate error sources for causes and effects. In several experiments, we tested this new model using the size of Markov violations as the empirical indicator of differential assumptions about the sources of error. As predicted by the model, the size of Markov violations was influenced by the location of the agents and was moderated by the causal structure and the type of causal variables. (shrink)

ABSTRACTThis paper addresses the problem of opaque sweetening and argues that one should use stochastic dominance in comparing lotteries even when dealing with incomplete orderings that allow for non-comparable outcomes.