Autophagy and YAP1‐WWTR1/TAZ signalling are tightly linked in a complex control system of forward and feedback pathways which determine different cellular outcomes in differing cell types at different time‐points after perturbations. Here we extend our previous experimental and modelling approaches to consider two possibilities. First, we have performed additional mathematical modelling to explore how the autophagy‐YAP1 crosstalk may be controlled by posttranslational modifications of components of the pathways. Second, since analogous contrasting results have also been reported for autophagy as a (...) regulator of other transduction pathways engaged in tumorigenesis (Wnt/β‐catenin, TGF‐β/Smads, NF‐kB or XIAP/cIAPs), we have considered if such discrepancies may be explicable through situations involving competing pathways and feedback loops in different cell types, analogous to the autophagy‐YAP/TAZ situation. Since distinct posttranslational modifications dominate those pathways in distinct cells, these need to be understood to enable appropriate cell type‐specific therapeutic strategies for cancers and other diseases. (shrink)

The contributors to this volume examine recent controversies about the importance of common sense psychology for our understanding of the human mind. Common sense provides a familiar and friendly psychological scheme by which to talk about the mind. Its categories tend to portray the mind as quite different from the rest of nature, and thus irreducible to physical matters and its laws. In this volume a variety of positions on common sense psychology from critical to supportive, from exegetical to speculative, (...) are represented. Among the questions posed are: Is common sense psychology an empirical theory, a body of analytic knowledge, a practice or a strategy? If it is a legitimate enterprise can it be naturalized or not? If it is not legitimate can it be eliminated? Is its fate tied to our understanding of consciousness? Should we approach its concepts and generalizations from the standpoint of conceptual analysis or from the philosophy of science? (shrink)

Leading invasion biologists sometimes dismiss critics and criticisms of their field by invoking “the straw man” fallacy. Critics of invasion biology are also labelled as a small group of “naysayers” or “contrarians”, who are sometimes engaging in “science denialism”. Such unfortunate labels can be seen as a way to possibly suppress legitimate debates and dismiss or minimize reasonable concerns about some aspects of invasion biology, including the uncertainties about the geographic origins and complex environmental impacts of species, and the control (...) programs against species perceived as “invasive”. In assessing the quality of the debate in this area, we examine the validity of the use of various strategies, including the “straw man” concept, and explore a range of potential logical fallacies present in some recent prominent discussions about invasion biology and so-called “invasive” species. The goal is to add some clarity to the concepts involved, point out some problematic issues, and improve the quality of the debates as the discussions move forward. (shrink)

The theme of this essay is rather simple, though its demonstration is not. It is that humans think reflexively or metamentally because -- and often in the forms in which -- they interpret each other. In this essay ‘metamental’ means ‘about mental’ and ‘reflexive mind’ means ‘a mind thinking about its own thoughts.’ To think reflexively or metamentally is to think about thoughts deliberately and explicitly, as in thinking that my current thoughts about metamentation are right. Thinking about thoughts requires (...) understanding thoughts as thoughts, as mental structures that represent; it also requires an ability to relate thoughts to other thoughts and to recognize such inter-thought relations. Since metamentation is essential to and uniquely distinctive of human minds, the idea that it originates in interpreting other minds can be encapsulated in the slogan that minds are minded because minds mind minds. This word play translates as: minds evolve into reflexive minds because they mind other minds -- where ‘minding other minds’ means interacting and bonding with other minds, being concerned or curious about them, representing their relations to the world, manipulating and using these relations for some purpose, and the like. All of this amounts (in my terminology) to interpreting other minds in social contexts of cooperation, communication, education, politics, and so on. It follows that intermental relations among individuals, handled by a distinct competence for interpretation, are essential to the evolution of abilities to represent intramental relations among thoughts, typical of a reflexive mind. I take ‘interpretation’ to be a convenient, short, and grammatically flexible label for what is known in philosophy as commonsense or folk psychology and in psychology as theory of mind, mindreading, or naive psychology. Interpretation is a cognitive rapport between an interpreter (she, in this book) and a subject (he), whereby she represents his mind-world relations, from the simplest, such as seeing.... (shrink)

Economic profit is produced by entrepreneurs, those special individuals able to detect and seize as yet unexploited market opportunities. Many large capitalist firms manage to deliver positive profits even in the most competitive environments. They can do so, thanks to internal entrepreneurs, a subset of their employees able to drive change and develop innovation in the workplace. This paper argues that the goal of increasing economic profit is fully consistent with the corporation doing good for society. However, there is little (...) justification for corporations to transfer the whole economic profit to shareholders. Economic agents entitled to receive the economic profit are precisely those who create this profit, namely the internal entrepreneurs. (shrink)

Some of the topics presented in this volume of original essays on contemporary approaches to belief include the problem of misrepresentation and false belief, conscious versus unconscious belief, explicit versus tacit belief, and the durable versus ephemeral question of the nature of belief. The contributors, Fred Dretske, Keith Lehrer, William Lycan, Stephen Schiffer, Stephen P. Stich, and the editor, Radu Bogdan, focus on the mental realization of belief, its cognitive and behavioral aspects, and the semantic aspects of its content. (...) This interdisciplinary study takes advantage of many new theories in what has become an important area of research. (shrink)

JUSTIFICATION and knowledge are thought to be closed under known implication..1 This widely shared assumption is embodied in the following principles of epistemic closure.

Starting from the cyclic principle in the process of a society's development, invoking „the end of history" that Hegel mentions, adding the paradoxical principle of Huntington's civilizations, of a unity in diversity, through which we can have a clear and universal image of the conflicts, as actions generated by a cultural-religious interaction, and passing these through the filter of the noble origin of the Occidental civilization, we renew a typology of the inter-societies conflict and we keep the possibility of finding (...) some methods for settling them. (shrink)

The article presents the preliminary results of the author’s study of the unedited homily De transfiguratione et eleemosyna, ascribed to John Chrysostom. The question of the manuscript tradition is first discussed. The article shows that Maurice Sachot is right when he indicates only the manuscript Romanus Angelicus gr. 125 as a manuscript witness of this homily and that the other two witnesses indicated by Pinakes are erroneous. Then, the descriptions of the folios that preserve the homily are analysed in the (...) light of a new examination of them. This re-examination shows that hitherto several sources that inspired the compiler have gone unnoticed. This is followed by a brief summary of the contents of the homily and an analysis of the passages in which almsgiving is mentioned.Contribution: The article offers a re-examination of the folios 353v–361 from the manuscript Romanus Angelicus gr. 125, the first presentation of the content of the homily De transfiguratione et eleemosyna, and tries to shed light on the association of the theme of the Transfiguration with almsgiving. (shrink)

In his inventory of the manuscript tradition of the homilies on the Transfiguration, Maurice Sachot stated that folios 46r-55r of the codex Parisinus graecus 1611 contain the homily In transfigurationem Domini (BHGn 1980a). He also stated that this text is unedited and that it is most probably a recension of the homily In transfigurationem Domini (CPG 5807; BHG 1980) attributed to Proclus of Constantinople. To date, however, this homily has remained unpublished and unstudied. After a brief presentation of the codex (...) Parisinus graecus 1611, this article brings to light a surprise that emerges from examining folios 46r-55r of the Parisian manuscript. CONTRIBUTION: The article proves that the homily In transfigurationem Domini (BHGn 1980a) is not a recension of the homily on the Transfiguration (CPG 5807; BHG 1980), but a compilation for which the beginning of the homily on the Transfiguration attributed to Proclus of Constantinople was used. (shrink)

The purpose of this paper is to assess the emergence of the pirate movements in the European Union. Our goal is to sketch the steps towards a research agenda for this grassroots political movement which gained momentum since 2009. To attain our goal we showed the re-signification of the concept of piracy in the debate around intellectual property and its institutional settlement. Afterwards we analysed the big political themes of several European Pirate Parties and their struggle to follow the preferences (...) of the median voter. We concluded with a set of hypotheses of which the most important is that the pirates will inscribe neither to the left nor to the right part of the political spectrum. (shrink)

Cet article porte sur les images créées à l’aide des intelligences artificielles génératives sur des plateformes telles que DALL-E, Midjourney ou Stable Diffusion à partir de mots saisis en langage naturel. L’article ne s’occupe pas de savoir si les images générées peuvent être considérées comme des œuvres d’art en termes de qualité esthétique, de paternité ou d’originalité artistique. Il s’occupe de savoir si l’intelligence artificielle générative peut créer dans les mêmes conditions que celles qui étaient autrefois prescrites à l’art, notamment (...) la capacité à représenter les choses non seulement telles qu’elles sont, mais aussi (ou surtout) telles qu’elles pourraient et devraient être. Mais l’exploration des possibilités par l’art ou par l’intelligence artificielle peut être comprise de multiples façons : la création selon le critère de la vraisemblance, la capacité à idéaliser la réalité ou à élargir nos concepts, ou encore la capacité à libérer l’imagination afin de produire le fantastique ou le surréel. Bien qu’une intelligence artificielle ait tendance à reproduire les stéréotypes esthétiques ou sociaux qui prévalent dans les bases de données, elle fait néanmoins preuve d’une certaine capacité à produire de la nouveauté au sens onto-logique (et non pas esthétique) du mot, en nous permettant de visualiser des nouveaux exemplaires des notions que nous ne pouvons pas définir autrement, telles que le style d’un artiste ou les concepts vagues aux frontières fluides et aux propriétés probables. (shrink)

AN INTENSIONAL INTERPRETATION OF TRUTH-VALUES* 1. Introduction In a profound and seminal paper of 1956 'Begrundung einer strengen Implikation', JSL), ...

Review of Ștefan Iloaie, Cultura vieții. Aspecte morale în bioetică (Culture of life. Moral aspects in bioethics) (Cluj -Napoca: Editura Renașterea, 2009).

In an attempt to trace the historical origins of Malebranche's reputation as an opponent of imagination, mainly in connection with style and eloquence, the author of this paper maintains that most of the arguments subsequently used against Malebranche may already be found in Bernard Lamy's La Rhétorique ou l'art de parler. Although Lamy might have been influenced by Malebranche, his approach to the use of passions and imagination relies rather on a theory of language and communication than on Malebranche's account (...) of the physiological effects of imagination. Therefore, the opposing views of Malebranche and Lamy on this question could be seen as premises for the French debates on the right and wrong use of the imaginative faculty that emerged at the turn of the 17th century. (shrink)

Cyber risk has become one of the greatest threats to firms in recent years. Accordingly, boards of directors must be continually vigilant about this danger. They have a duty to ensure that the companies adopt appropriate cybersecurity measures to manage the risk of cyber fraud. Boards should also ensure that the firm disclose material cyber risk and breaches. We examine how the board’s gender composition can influence the extent of such disclosure, based on a sample of the companies listed on (...) the S&P/TSX 60 Index over the period 2014–2018. Results show evidence of a positive association between the presence and level of cybersecurity disclosure and board gender diversity. However, the board must boast a critical mass of at least three women before this positive impact can be observed. Our findings contribute to the debate on the importance of gender diversity by adding the concept of the positive influence of heterogeneity on cyber disclosure. We also augment the literature on the critical mass of women in boardrooms by providing empirical evidence that three or more women constitute the threshold for better governance. Our study has important implications for investors, stakeholders and regulators. If investors wish to increase cybersecurity disclosure, they should ask for more diversified boards. Our findings support regulators in their efforts to increase women’s representation on boards by providing empirical evidence of better outcomes with this type of board composition. (shrink)

Aside from brute force, there are several philosophically respectable ways of eliminating the mental. In recent years the most popular elimination strategy has been directed against our common sense or folk psychological understanding of the mental. The strategy goes by the name of eliminative materialism (or eliminativism, in short). The motivation behind this strategy seems to be the following. If common sense psychology can be construed as the principled theory of the mental, whose vocabulary and principles implicitly define what counts (...) as mental, then eliminating the theory is eliminating its subject matter. If the theory is shown to be false, then its subject matter does not exist. If, in other words, common sense psychology can be shown to describe and explain nothing real in human cognition, then the mental itself is a fiction. (shrink)

An important part of responsible business practices is compliance with the law. This article details what actually happens when the laws of the host country fail to ensure adequate protection. The focus here is on land dispossession and loss of livelihood in relation to a gold mine project in central Ghana. How is it that a well‐known international company—Newmont—with its own corporate social responsibility (CSR) statements sets up a project in the year 2003 that displaces subsistence farmers from their land (...) without compensating in cash or with replacement land? The analysis identifies the factors that lead the company to not compensate farmers for their lost land: cost‐cutting, strict adherence to the law, CSR commitment that was new and not internalized, complexities of the Ghanaian land tenure system, peer pressure to preserve the status quo, selection of an “old‐school” CSR manager, and the inadequacy of Ghanaian mining law to account for relatively novel, “open‐pit” mining techniques. However, the specter of famine raised by civil society activism, the involvement of the International Financial Corporation, and a better qualified CSR team constitute another set of factors that lead to a comprehensive package of livelihood improvement measures. There is a contrast between the complexity, long‐term, and advanced type of assistance Newmont currently envisages and the backward, short‐term, formalism, and brutality of denying compensation for land back in 2003. This research is based on the extensive documentation Newmont makes available on its web site, interviews conducted in Ghana, and literature research. (shrink)

Images under Attack: Soup on Paintings and the Decline of Aesthetic Contemplation. In 2022, two cans of tomato soup were thrown over Van Gogh’s Sunflowers at the National Gallery in London by two climate activists. The aim of this paper is not to explain the motives behind the protest in terms of environmental activism, but to address the implications of this phenomenon for the status of artistic images in our time. The protest in question is one of the many symptoms (...) of the fact that images associated with a pure state of gaze have become morally dubious due to a certain moralistic turn in contemporary discourses on art. Consequently, what seems to be lost in today’s movements of moralizing aesthetics, whether in art or in environmental activism, is not only the “aura” of an artwork, but also the idea that the contemplation of beauty in and for itself would provide a foundation for humans’ moral vocation. In a gaseous state of art (Y. Michaud) in which the transient effects of things are more important than their essence, the moralistic tendencies combined with the lack of moral foundations can no longer conceive of the ethical effects of images without explicit moral content, thus calling for a new form of heteronomy in art. (shrink)

Although the Internet is frequently referred to as a global public resource, its functioning remains predominantly controlled by private actors. The Internet brought about significant shifts in the way we conceptualize governance. In particular, the handling of “big data” by private intermediaries has a direct impact on routine practices and personal lives. The implementation of the “right to be forgotten” following the May 2014 decision of the Court of Justice of the European Union against Google blurs the boundaries between the (...) public and the private, and extends the responsibilities of the latter to court-style decision making. This article analyzes the regulatory developments in this area and the implications of outsourcing of important governance practices to private intermediaries. It looks at the decision-making process for the “right to be forgotten” to illustrate the extent to which the hybridization of such procedures results in new arrangements between public and private ordering in Internet governance. (shrink)

Through the efforts of the Institut de Recherche et d’Histoire des Textes (IRHT), a list of manuscripts is available that preserves homilies on the healing of the paralytic. Included in this list is the codex Athonensis, Lauras A 112 (Eustratiadis 112), which, according to those who provided its second description, preserves in the last four folios ‘a homily on the paralytic by John Chrysostom’. After a brief presentation of what is known about this codex, this article offers a detailed examination (...) of the codex’s last four folios, revealing that the description of them by Spyridon Lauriotis and Sophronios Eustratiadis is inaccurate. Contribution: This article provides the first thorough examination of the last four folios of the codex Athonensis, Lauras A 112 (Eustratiadis 112), demonstrating that they do not contain ‘a homily on the paralytic by John Chrysostom’ but rather several fragments of homilies on Thomas, Mid-Pentecost and the Ascension. Thus, the article contributes to the description of the codex and to the identification of a previously unknown manuscript witness to several homilies. (shrink)

Drawing on recent theories and debates concerning the everydayness of non-artistic and even private aesthetic experiences, this article aims at differentiating new ways of dealing with revulsion at the intersection of negative and everyday aesthetics, as another manner of extending or transcending the scope of traditional art-oriented aesthetics. The paradigms that I will trace in the history of negative aesthetics are not mere occurrences of disgust or repulsiveness in art and in everyday life, but ways of addressing the repulsive in (...) relation to the culturally variable scope of art and aesthetics. Besides the classical paradigm that associates repugnant subjects with their pleasure-inducing imitations in art, and the transgressions of modern and contemporary art that increasingly shocked their audience, revulsion can also be regarded as a form of displeasure linked to the quotidian, yet aesthetically relevant forms of life. By virtue of this ordinary nature, which is not unfamiliar to other (non-Western) cultures, revulsion could be placed at the core of everyday aesthetics, since it confirms both the transition from contemplation to action in recent aesthetics, that is, the practical preoccupation with the aesthetic quality of living, and the broader redefinition of aesthetics in terms of sensory reactions. (shrink)

Information is the fuel of cognition. At its most basic level, information is a matter of structures interacting under laws. The notion of information thus reflects the (relational) fact that a structure is created by the impact of another structure. The impacted structure is an encoding, in some concrete form, of the interaction with the impacting structure. Information is, essentially, the structural trace in some system of an interaction with another system; it is also, as a consequence, the structural fuel (...) which drives the impacted system's subsequent processes and behavior. Information takes various forms because the world has many levels of compositional and functional complexity, under different constraints. The key constraints that matter in the understanding of information are natural patterns of organization, or types, and systematic correlations among types, or laws. These level- sensitive constraints, in the form of types and laws, shape the very form in which information is tokened in some structure, that is, the very form in which it is encoded. As a result, the information-producing interactions bring about different sorts of structures, with various sorts of causal effects and functions, whence so many ways in which information is coded and utilized. (shrink)

En tant que modèle cosmologique, les structures mises en place par le platonisme s’apparentent formellement à celles de la cosmologie biblique. C’est laraison pour laquelle le christianisme n’a pas hésité à y trouver un moyen propice pour exprimer son propre mystère. Malgré ces similitudes extérieures, un planplus rapproché permet de constater que les deux ensembles appréhendent l’existence de manière dissemblable. Sur la toile de fond de la création biblique, les mystères connexes de l’Incarnation et de l’Ascension, tels qu’ils sont compris (...) par l’intelligence dogmatique chrétienne, s’écartent radicalement de l’approche métaphysique qui avait présidé à l’élaboration du système de Platon – et ce en dépit des tentations à teinte «platonicienne» qui se font jour dans le christianisme avec l’émergence des doctrines ascétiques. Sans aborder les complexités de cette dernière problématique, cet article entend revisiter, comme en négatif, la valeur positive du corps dans le christianisme. (shrink)

”The Barometer of Flaubert or Literature and Reality”. Discussing the relationship between literature and reality, this study focuses on the analysis of the“reality effect” (effet de réel) which is applied to the narrative technique in Gogol’s novel Dead Souls by revisiting it through a Nabokovian perspective.

Boyer's minimal model of ownership psychology suggests that joint possession triggers representations of collective agency. However, many forms of co-ownership based on cooperation or competition can be represented as a set of P() or L() tags without inferring a unifying collective entity. Moreover, representations of partible ownership are required to engage in cooperative production and distribution of resources.

Our perceptions, beliefs, thoughts and memories have objects. They are about or of things and properties around us. I perceive her, have beliefs about her, think of her and have memories of her. How are we to construe this aboutness (or ofness) of our cognitive states?' There are four major choices on the philosophical market. There is an interaction approach which says that the object of cognition is fixed by and understood in terms of what cognizers physically and sensorily interact (...) with - or, alternatively, in terms of what the information delivered by such interaction is about. There is the satisfactional approach which says that the object of a cognitive state is whatever satisfies the representation constitutive of that state. There is also a hybrid approach which requires both physical/sensory interaction and representational satisfaction in the fixation of the object of cognition. And there is, finally, the direct acquaintance approach which says that only an immediate cognitive contact with things and properties can establish them as objects of cognition. The latter, as far as I can tell, goes the way perception goes, so only the remaining three approaches look like serious contenders. (shrink)

Self-ascriptions of thoughts and attitudes depend on a sense of the intentionality of one’s own mental states, which develops later than, and independently of, the sense of the intentionality of the thoughts and attitudes of others. This sense of the self-intentionality of one’s own mental states grows initially out of executive developments that enable one to simulate one’s own actions and perceptions, as genuine off-line thoughts, and to regulate such simulations.

Kant identified in the “spectators’” enthusiastic response to the French Revolution the clear sign of a moral disposition in humankind. Following Hannah Arendt’s classic interpretation, but departing from it in important respects, I attempt to show in this paper that the “spectatorial” account of Kant’s view of the French Revolution makes sense only if it is understood in terms of a subject’s aesthetic response to objects of natural sublimity, and only if this aesthetic experience is instrumentalized for purposes of moral (...) education. (shrink)