Drug design methods have made significant new advances over the last ten years, mainly in the areas of molecular modelling. In more recent times important developments in theory have led to a different type of modelling becoming possible, the so‐called de novo or automated design algorithms. In this new method the programs perform much of the chemist's thinking, in finding appropriately sized chemical groups to fit into a target site. However this is a combinatoric problem which has no general analytical (...) solution; it is ripe for optimization. Other advances, such as combinatorial chemical synthesis and screening, will dramatically influence the search for new lead structures for target sites, which at present are poorly understood. Already these methods are being applied to peptide libraries. Peptides do not make good drug compounds because of their poor bioavailability; further, their flexibility reduces their affinity. In some cases peptide backbones can be removed and replaced with rigid non‐peptide scaffolds. (shrink)

Oxford Studies in Philosophy of Religion is an annual volume offering a regular snapshot of state-of-the-art work in this longstanding area of philosophy that has seen an explosive growth of interest over the past half century.

Theories of consciousness have a long and controversial history. One well-known proposal — integrated information theory — has recently been labeled as ‘pseudoscience’, which has caused a heated open debate. Here we discuss the case and argue that the theory is indeed unscientific because its core claims are untestable even in principle.

Philip James Jones, a Fellow of the British Academy, was one of the most distinguished, complex, and challenging of medieval historians. His works on the Italian city-states of the thirteenth to fifteenth centuries and on Italy's agrarian history are monuments built to last, benchmarks that defined the field for a generation. Jones was elected a Fellow of the British Academy in 1984 and was awarded the Serena Medal for Italian studies in 1988. He won a major open scholarship in (...) Modern History at Wadham College, University of Oxford. Jones took a First in Modern History in 1945 and was appointed to a research studentship at Magdalen College. He had also secured a temporary teaching post at Glasgow University. All Jones's previous works flowed into the 700 pages of his mammoth book Italian City-State: from Commune to Signoria. (shrink)

ABSTRACTPresenting information in a coherent fashion has been shown to increase processing fluency, which in turn influences affective responses. The pattern of responses have been explained by two...

Young people have an enormous stake in the present and future state of Earth. Almost half of the human population is under the age of 25. If young people’s resources of energy, time, and knowledge are misdirected towards violence, terrorism, socially-isolating technologies, and unsustainable consumption, civilization risks destabilization. Yet, there is a powerful opportunity for society if young people can participate positively in all aspects of sustainable development. In order to do so, young people need education, political support, resources, skills, (...) and hope. This volume offers a global perspective on education initiatives by and for young people that promote a transition to sustainability. It includes 38 essays co-authored by 68 contributors from 25 nations, representing a diversity of geography, gender, and generation. "The development of youth leadership has been a central concern of my professional work. Young people have a lot to offer to sustainable development and should participate in planning for our planet’s future. This rich collection of theoretical and practical approaches captures the growing response of young people to this challenge. I am particularly pleased with the attention paid to the role of often-underrepresented regions of the world, to the role of women, and to the Earth Charter in the creating of a peaceful and sustainable future." Julia Marton-Lefèvre, Director General of IUCN (International Union for Conversation of Nature), and former Rector of the University for Peace "This book is a rich, global tapestry depicting the inter-linkages among youth, education and sustainable development. What is particularly interesting is that it shows how education, at all levels, can be a powerful engine for promoting sustainability. This work is an important contribution to the United Nations Decade of Education for Sustainable Development." Goolam Mohamedbhai, Secretary-General, Association of African Universities, and Past President, International Association of Universities "This important and skillfully-prepared book comes at a critical time.... A great strength of this volume is that it blends together theoretical and practical insights regarding education for sustainable development by and for young people. It is written from diverse cultural perspectives from all world regions. Readers, from many fields, especially young people and their teachers, will find it timely and relevant. I hope that it will inspire the younger generation to get involved in seeking solutions to the challenges we face." James Gustave Speth, Former Administrator of the United Nations Development Programme, and Dean Emeritus of the School of Forestry and Environmental Studies at Yale University "It is my hope that you are inspired, as I have been, by Young People, Education, and Sustainable Development: Exploring Principles, Perspectives, and Praxis, for the stories in this volume are full of the possibilities that emerge when we honor and support young people." Ruud Lubbers, Former Prime Minister of The Netherlands, and past United Nations High Commissioner for Refugees. (shrink)

Description: Since its inception, the discussion surrounding Open Theism has been dominated by polemics. On crucial philosophical issues, Openness proponents have largely been devoted to explicating the underlying framework and logical arguments supporting their perspective against competing theological and philosophical perspectives. As a result, very little constructive work has been done on the interconnections between Open Theism and the natural sciences. Given the central place of sciences in today's world, any perspective that hopes to have a broad impact must necessarily (...) address such disciplines in a sustained and constructive manner. To date such engagements from the Openness perspective have been rare. God in an Open Universe addresses this deficiency. This book demonstrates that Open Theism makes a distinctive and highly fruitful contribution to the conversation and constructive work occurring between philosophy, theology, and the sciences. The various essays explore subjects ranging from physics to prayer, from special relativity to divine providence, from metaphysics to evolution, and from space-time to God. All who work at the intersection of theology and the sciences will benefit greatly from these essays that break new ground in this important conversation. Endorsements: ""These essays present what is, in my view, the most promising development in theological thinking in our time, and they do so in a way that is both scholarly and accessible. The book is a must for anyone interested in Christian faith and in science."" -Keith Ward University of Oxford ""Open theists affirm the same openness of the future that religious believers assume when they pray and almost all humans assume when they act. The open future is intuitive; but can it be rigorously defended? God in an Open Universe shows that it can. Open theism has always been an attractive view of God; now it becomes a philosophically rigorous one as well. -Philip Clayton Claremont School of Theology About the Contributor(s): William Hasker is Profesor Emeritus of Philosophy at Huntington University. He is the author of numerous articles and five books, including The Emergent Self and The Triumph of God Over Evil. Thomas Jay Oord is Professor of Theology and Philosophy at Northwest Nazarene University. He is the author or editor of more than a dozen books, including Defining Love and Creation Made Free. Dean Zimmerman is Professor in the philosophy department at Rutgers, The State University of New Jersey. He is editor or co-editor of several books, including (with Peter van Inwagen) Persons: Human and Divine. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:BOOK REVIEWS 545 Haroutunian, would have balked at the notion that their " empiricism " could be abstracted from the christological and trinitarian confession 0£ the church. In general, it would seem that a genuinely " empirical" approach would seek to engage the actual truth claims of religious com· munities on their own terms-even when those claims conflict with historicist suppositions. Second, in so far as Dean thinks there (...) is a uniquely American reli· gious experience or style of thought, privileging that style seems a dangerous move indeed. Dean is not unaware of the dangers. He specifically denies that he is engaging in any form of " American exceptionalism " (p. 25) ; it is simply that an " appropriately American historicism, centering on American culture, would have a greater chance of suggesting practices that work for and are true for America " (p. 24). But I am skeptical that such disclaimers address the real problem. Near the very end of the book, Dean suggests that a modi· fied naturalism might lead to " a notion of God that was more genuinely American than anything earlier," culminating in the recognition that " American thought about God is really the thought of a national com· munity" (p. 144). Descriptively that may well be the case; but then the Christian theologian must seek norms elsewhere. History Making History does not show us how historicist insigh~ might be incorporated into ecumenical, trinitarian theology, but that does not mean the attempt will prove unfruitful. Meanwhile, this bit of philosophical tale-telling will hold the interest of readers theological and otherwise. JOSEPH L. MANCINA Yale University New Haven, Connecticut Medical Ethics: Sources of Catholic Teaching. By KEVIN D. O'ROURKE, O.P. and PHILIP BOYLE, O.P. St. Louis: Catholic Health Associa· tion, 1989. Medical Ethics: Common Ground for Understanding. By KEVIN D. O'RouRKE, O.P. and DENNIS BRODEUR. St. Louis: Catholic Health Association, 1989. Healthcare Ethics: A Theological Analysis. By KEVIN D. O'RouRKE, O.P. and BENEDICT ASHLEY, O.P. 3rd ed. St. Louis: Catholic Health Association, 1989. Sources of Catholic Teaching is a compendium of recent "official" statements by Roman Catholic ecclesiastical bodies on issues concern· ing medical ethics. Arranged alphabetically according to topics, this col- 546 BOOK REVIEWS lection of statements from the papacy, the Roman Congregations, and the conferences of Catholic bishops could prove to he a very helpful reference tool. It contains a brief introduction which seeks to explain the role of these statements in the Catholic moral theology and Catholic medical ethics, a table of contents of the statements included, and then the statements themselves. In most instances it does not contain the entire document or statement hut only excerpts therefrom. There are some weaknesses in this work. First, these statements are not self-explanatory; they are in need of interpretation and explanation in many instances. But the authors present only the bald text and do not offer any explanatory comments. They apparently presume that these statements are pellucid to the reader, hut this is an unwarranted pre· sumption. For example, clarifying comments should have been added to the statement from the Declaration on Euthanasia because the allocution of Pius XII about giving lethal doses of analgesia is not entirely clear. A second difficulty with this work is the brief and somewhat insubstantial introduction on conscience and the role these statements should play in the formation of conscience. This sort of work invites a substantial and extended commentary on the nature of moral judgments, the relationship of conscience to the natural law, and the authority of these statements. The authors note that not all of the official statements issued by various organs of the Church are of equal authority, hut they do not try to identify the specific authoritative status of the various statements they include in their work. The reader is thus left to his or her own devices to determine, for example, the relative weight of statements of the administrative hoard of the NCCB versus statements of state episcopal conferences. A still further problem is that some of the statements are of virtually no significant authority for Catholics. For example, the statement of the administrative hoard of the NCCB on AIDS is of questionable... (shrink)

This book consists of fifteen new essays and an introduction by Zimmerman. Most of the authors are Christian philosophers in the ‘analytic’ tradition, and the book is of particular interest to readers of that sort; but there is nothing here that will interest only Christians. As the title suggests, all the essays have at least something to do with persons as such, and most deal with metaphysical issues. Beyond that they are pretty disparate. Seven papers are on substance dualism or (...) idealism, which get a more sympathetic hearing than current fashion would dictate. Lynn Rudder Baker, Hud Hudson, and Peter van Inwagen discuss materialist accounts of human people that they have developed elsewhere. There are papers on specifically Christian doctrines--immortality, divine incarnation, the trinity, and original sin--and one on the value of human people by Philip Quinn. For better or worse, there is almost no discussion of the existence of God. Even so, no one can accuse the authors of avoiding the big questions and retreating to narrow, technical issues. There is as much at stake in these essays as there is in any work of Plato or Kant. (shrink)

This paper argues that the language of rights cannot express distinctively ecofeminist insights into the treatment of nonhuman animals and the environment. An alternative is proposed in the form of a politicized ecological ethic of care which can express ecofeminist insights. The paper concludes with consideration of an ecofeminist moral issue: how we choose to understand ourselves morally in relation to what we are willing to count as food. "Contextual moral vegetarianism" represents a response to a politicized ecological ethic of (...) care. (shrink)

Psychedelic drugs such as psilocybin, LSD and DMT are known to induce powerful alterations in phenomenology. Perhaps of most philosophical and scientific interest is their capacity to disrupt and even “dissolve” one of the most primary features of normal experience: that of being a self. Such “peak” or “mystical” experiences are of increasing interest for their potentially transformative therapeutic value. While empirical research is underway, a theoretical conception of the mechanisms underpinning these experiences remains elusive. In the following paper, psychedelic-induced (...) ego-dissolution is accounted for within an active inference framework, as a collapse in the “temporal thickness” of an agent’s deep temporal model, as a result of lowered precision on high-level priors. The argument here is composed of three moves: first, a view of the self-model is proposed as arising within a temporally deep generative model of an embodied organism navigating an affordance landscape in the service of allostasis. Next, a view of the action of psychedelics as lowering the precision of high-level priors within the generative model is unpacked in terms of a high Bayesian learning rate. Finally, the relaxation of high-level priors is argued to cause a “collapse” in the temporal thickness of the generative model, resulting in a collapse in the self-model and a loss of the ordinary sense of being a self. This account has implications for our understanding of ordinary self-consciousness and disruptions in self-consciousness present in psychosis, autism, depression, and dissociative disorders. The philosophical, theoretical and therapeutic implications of this account are touched upon. (shrink)

A core project for deep ecologists is the reformulation of the concept of self. In searching for a more inclusive understanding of self, deep ecologists often look to Buddhist philosophy, and to the Japanese Buddhist philosopher Dōgen in particular, for inspiration. I argue that, while Dōgen does share a nondualist, nonanthropocentric framework with deep ecology, his phenomenology of the self is fundamentally at odds with the expanded Self found in the deep ecology literature. I suggest, though I do not fully (...) argue for it, that Dōgen’s account of the self is more sympathetic to one version of ecofeminism than to deep ecology. (shrink)

Finding a way to come to terms with the disvalues in the evolutionary world is a particular challenge in the light of Neo‐Darwinian theories. In this article I trace the shift in Christopher Southgate's work from a focus on theodicy to a theologian of glory. I am critical of his rejection of the tradition of the Fall, his incorporation of disvalues into the work of divine Glory, and the specific theological weight given to scientific content. I offer a critique of (...) Holmes Rolston III's approach to the valuation of nature that I believe has influenced Southgate's theology. Constructively, I offer an alternative that seeks to recover an understanding of the origin of evil and the Adamic event that draws on the work of Paul Ricoeur. I also draw on the work of anthropologist Tim Ingold for an alternative philosophical approach to evolution which opens up a space for a recovery of the concepts of creaturely Sophia and shadow Sophia in the work of Sergius Bulgakov. (shrink)

I discuss controversial claims about the status of non-human animals as moral beings in relation to philosophical claims to the contrary. I address questions about the ontology of animals rather than ethical approaches as to how humans need to treat other animals through notions of, for example, animal rights. I explore the evolutionary origins of behavior that can be considered vices or virtues and suggest that Thomas Aquinas is closer to Darwin's view on nonhuman animals than we might suppose. An (...) appreciation of the complexity of the emotional lives of social animals and their cooperative behaviors in light of the work of animal ethologists such as Frans de Waal and Marc Bekoff suggests that social animals can be considered moral in their own terms. I discuss the charge of anthropomorphism, drawing on the work of archaeologist Steven Mithen, and consider arguments for the evolution of conscience in the work of anthropologist Christopher Boehm. Only the biological basis for the development of conscience and religion has evolved in nonhuman animals, and this should not be confused with sophisticated moral systems of analysis or particular religious beliefs found in the human community. (shrink)

In this paper I draw on Thaddeus Metz’s pioneering work in African ethics, and particularly his account of the concept described by the terms ubuntu, botho, hunhu or utu, to sketch an African normative understanding of the act of rebellion against the authority of the state. Most commonly articulated in the phrase “a person is a person through other persons”, ubuntu is interpreted by Metz as a unique communitarian moral principle which can be described in its essence as the claim (...) that “actions are right, or confer ubuntu on a person, insofar as they prize communal relationships, ones in which people identify with each other, or share a way of life, and exhibit solidarity toward one another, or care about each other’s quality of life”. On the face of it, this principle appears at odds with rebellions against state authority. Following Metz, I argue, however, that a deeper grasp of this principle does, in fact, provide a justification for instances of civilian rebellion against state authority, under appropriate circumstances. (shrink)

The possibility of using private military and security companies to bolster the capacity to undertake intervention for human rights purposes has been increasingly debated. The focus of such discussions has, however, largely been on practical issues and the contingent problems posed by private force. By contrast, this article considers the principled case for privatising humanitarian intervention. It focuses on two central issues. First, does outsourcing humanitarian intervention to private military and security companies pose some fundamental, deeper problems in this context, (...) such as an abdication of a state's duties? Second, on the other hand, is there a case for preferring these firms to other, state-based agents of humanitarian intervention? For instance, given a state's duties to their own military personnel, should the use of private military and security contractors be preferred to regular soldiers for humanitarian intervention? (shrink)

While there are no serious arguments in favor of there being no state control whatsoever over the private ownership and employment of firearms, there are significant arguments on the other extreme of the ‘gun control debate’ which contend for bans on the private ownership of firearms or some subset thereof. In this paper I argue that gun ban proponents like Jeff McMahan and Nicholas Dixon confuse the risk or likelihood of being confronted by an attacker intent on serious or lethal (...) harm with the right to defend oneself when faced by such an attacker. When this distinction is properly understood it becomes clear that arguments for the banning of all privately owned guns, or particular classes of guns, cannot stand so long as the firearms in question can be reasonably considered to be an effective means for individuals to defend themselves against attackers intent on serious or lethal harm. (shrink)

abstract David Rodin has recently put forward a compelling but disturbing argument to the effect that the traditional justification in Just War Theory of a state's right to self‐defence (what Rodin calls national‐defence), which is derived from the legitimate case of personal self‐defence, fails. He concludes that the only way to justify forceful responses to aggression against states by other states or non‐state groups is by viewing the right to do so as falling under a form of law‐enforcement, which in (...) turn requires the existence of some overarching universal state. In this paper I argue that there exists a possible justification for national‐defence that Rodin has overlooked due to an underlying commitment to what Charles Taylor calls ‘the primacy of rights thesis’. My claim is that a particular family of views that see human identity as being crucially bound up with society offers the resources to avoid the pitfalls that Rodin points out befall other attempts to justify national‐defence. (shrink)

Arne Naess has come under many influences, most notably Gandhi and Spinoza. The Buddhist influence on his work, though less pervasive, provides the most direct account of key deep ecological concepts such as Self?realization and intrinsic value. I read Ecosophy T as a rigorously phenomenological branch of Deep Ecology. like early Buddhism, Naess responds to the human suffering that causes environmental destruction by challenging us to return to the reality of lived experience. This Buddhist reading clarifies, but it also complicates. (...) It reaffirms Naess's essential vision, but it challenges him at two points: first, to affirm that Self?realization is a process of co?realization with all beings, not just with sentient beings. Second, while this reading accepts that humans do not create the value of nature, it questions whether its value is best expressed in terms of the ?intrinsic value? of radical environmental ethicists. (shrink)

An overwhelming majority of business travelers are now members of frequent flier programs operated by the airline industry. This article addresses relevant ethical issues, particularly employee perceptions of ethical issues, in such programs. A structured questionnaire technique, supported by personal interviews, was used to gather insights into frequent flier practices and attitudes. A fundamental conclusion of the research is that (1) significant ethical dilemmas are posed by frequent flier programs, (2) employees and employers generally choose to ignore these ethical dilemmas, (...) and (3) employee perception of the ethical issues in frequent flier programs is not significantly influenced by employee attributes such as education level, salary, organizational position, age or sex. Recommendations are offered to reduce the inherent ethical dilemmas in frequent flier programs. (shrink)

This article poses a challenge to contemporary theories in psychology that portray empathy as a negative force in the moral life. Instead, drawing on alternative psychological and philosophical literature, especially Martha Nussbaum, I argue that empathy is related to the virtue of compassion and therefore crucial for moral action. Evidence for evolutionary anthropological accounts of compassion in early hominins provides additional arguments for its positive value in deep human history. I discuss this work alongside Thomistic notions of practical wisdom, compassion, (...) misericordia, and the importance of reason in the moral life. The tension between “bottom up” accounts of empathy and that according to a theological interpretation of “infused” virtues also needs to be addressed. From a secular perspective, infused virtue is a projection of the ideal moral life, but from a theological perspective, it is a way of understanding how human capacities through the action of grace can reach beyond what seem to be the limits of psychological moral identity. (shrink)

Philosophy has often been criticized for privileging the abstract; this volume attempts to remedy that situation. Focusing on one of the most concrete of human concerns, food, the editors argue for the existence of a philosophy of food.

Since its inception in the years following World War II, the green revolution has been defended, not just as a technical program designed to alleviate world hunger, but on moral grounds as a program to achieve world peace. In this paper, I dispute the moral claim to a politics of peace, arguing instead that the green revolution is warist in its treatment of the environment and indigenous communities, and that the agricultural practices that the green revolution was designed to supplant—principally (...) indigenous women’s agriculture—are forms of ecological peacemaking, akin to pacifism. I argue, as well, that the warist intentions of the green revolution are characteristic of a form of domination called developmentalism. A complete understanding of domination necessitates linking developmentalism with other forms of domination such as racism, sexism, and naturism. (shrink)

This volume offers a contribution to Teilhardian scholarship with a particular focus in mind, namely his significance in current debates about the human relationship with the natural world. His cosmic mysticism and intense interest in both cosmological and evolutionary sciences are highly relevant to current debates about how best to construct a meaningful spirituality for the twenty first century. not only does this book probe more deeply into his mystical insights in ways that challenge the reader's understanding of spirituality, it (...) also offers a critical revision of aspects of his thought in the light of current debates in evolutionary science, ecotheology and the challenges posed by environmental ethics. By focusing on people, and the planetary context in which people are situated, Teilhard takes us beyond the current debates between anthropocentrism and biocentrism that have characterised contemporary discussion about environmental ethics. The volume highlights areas where scholars have different interpretations of Teilhard's thought, raising new and interesting areas of debate that have been ignored in the past. It also points to the significance of his thought for developing a creative and mutual exchange between Eastern and Western Christian traditions. (shrink)

United States Army Special Forces who deployed to Iraq in mid-2014, and who were seeking to help Iraqi forces to combat Islamic State faced a considerable challenge: how could a force of fewer than 50 operators provide guidance and support to their Iraqi allies while also keeping in line with Washington’s policy of seeking to avoid any possibility of combat casualties among deployed U.S. Special Forces? Their solution to this dilemma came to be dubbed ‘Remote Advise and Assist’. By cobbling (...) together a system of voice and text communications, cameras, interactive maps and mobile handsets, these Special Forces personnel found they could ‘virtually accompany’ their Iraqi partners into hot zones where U.S. boots on the ground were forbidden. This approach seems to have been extremely successful, but potentially raises a range of ethical concerns. Against the backdrop of a general account of the ethics of employing surrogate forces, this paper explores the ethical questions raised by the practice of ‘Remote Advise and Assist’. (shrink)

Abstract This paper argues that a genuine engagement of Christianity with evolution needs to include a discussion of Christology. Further, it develops a particular approach to Christology through a theo-dramatic account of incarnation. The somewhat static post-Chalcedon theological categories of divine and human natures are hard to square with contemporary evolutionary accounts of human origins. Once the divine Logos is portrayed in the active categories of Wisdom it becomes easier to envisage divine and creaturely wisdom coexisting in the person of (...) Christ. I argue, in particular, that a focus on God's agency through a modified version of Hans Urs von Balthasar's account of theo-drama invites participation and affirms human agency in a way that grand narratives do not. More particularly, drawing on examples from hominid evolution, contemporary discussion of paleontology and cooperative evolutionary theories, I suggest that the most convincing accounts of evolutionary biology fit into this theo-dramatic account more readily than alternatives. As such, in the spirit of Robert Boyle, this paper deliberately blurs the categories of revealed and natural theology by arguing that we can make sense of the former through concentration on the latter. (shrink)

Few thinkers have had as much impact on contemporary philosophy as has Alvin Plantinga. The work of this quintessential analytic philosopher has in many respects set the tone for the debate in the fields of modal metaphysics and epistemology and he is arguably the most important philosopher of religion of our time. In this volume, a distinguished team of today's leading philosophers address the central aspects of Plantinga's philosophy - his views on natural theology; his responses to the problem of (...) evil; his contributions to the field of modal metaphysics; the controversial evolutionary argument against naturalism; his model of epistemic warrant and his view of epistemic defeat; and his recent work on mind-body dualism. Also included is an appendix containing Plantinga's often referred to, but previously unpublished, lecture notes entitled 'Two Dozen Theistic Arguments', with a substantial preface to the appendix written by Plantinga specifically for this volume. (shrink)

Abstract This paper addresses the teaching of mandatory ethics courses in a military context, with particular reference to the Service Academies of the United States Armed Forces. In seeking to optimize the core ethics course's potential to develop Midshipmen and Cadets' moral reasoning skills I suggest a model that employs case-based scenarios, woven together into a metanarrative, in place of the traditional historical case study and in a manner that gives students deliberate, guided practice in ethical decision-making. The described model (...) also commends a resource- and pedagogy-driven partnership between civilian philosophers/ethicists and senior military officers in teaching the course. Also proposed is the deliberate use of a simple but formal method of applying the central ethical theories usually taught in such courses, what I call ?ethical triangulation?. The employment of Computer Aided Argument Mapping is also recommended. (shrink)