In 1959, the Charles Darwin Station and the Galápagos National Park were established, formally inaugurating conservation on the archipelago. In the same year, a utopian colony from the United States arrived. Whereas scholars have dismissed the latter and focused on the former, this essay unveils the science-inspired utopianism common to both enterprises. Investing science with the exclusive role of producing all knowledge and steering politics, leaders of the two initiatives aspired not only to protect nature but also to forge a (...) new humanity. Describing how such ambitions burst along lines of race, class, and nationality, I argue that these enterprises consolidated the current understanding of the Galápagos as “pristine”: a site fit for research and tourism but unhospitable to people. Drawing on archival and historical documents, this essay aims to reinvigorate two conversations: one between science and technology studies and conservation, and the other between STS and utopian studies. If recent attempts at bridging the divide between science and imagination have emphasized how powerful actors shape human society, this essay considers the long-lasting effects of scientific imaginaries on a politics of nature. (shrink)

Implanting deep brain stimulation (DBS) electrodes in patients with Parkinson’s disease often results in the appearance of a non-infectious, delayed-onset edema that disappears over time. However, the time window between the DBS electrode and DBS stimulating device implant is often used to record local field potentials (LFPs) which are used both to better understand basal ganglia pathophysiology and to improve DBS therapy. In this work, we investigated whether the presence of post-surgery edema correlates with the quality of LFP recordings in (...) eight patients with advanced Parkinson’s disease implanted with subthalamic DBS electrodes. The magnetic resonance scans of the brain after 8.5 ± 1.5 days from the implantation surgery were segmented and the peri-electrode edema volume was calculated for both brain hemispheres. We found a correlation (ρ = −0.81, p < 0.0218, Spearman’s correlation coefficient) between left side local field potentials of the low beta band (11–20 Hz) and the edema volume of the same side. No other significant differences between the hemispheres were found. Despite the limited sample size, our results suggest that the effect on LFPs may be related to the edema localization, thus indicating a mechanism involving brain networks instead of a simple change in the electrode-tissue interface. (shrink)

There is an urgent need in philosophy of mathematics for new approaches which pay closer attention to mathematical practice. This book will blaze the trail: it offers philosophical analyses of important characteristics of contemporary mathematics and of many aspects of mathematical activity which escape purely formal logical treatment.

According to the orthodox account developed by Kaplan, indexicals like I, you, and now invariably refer to elements of the context of speech. This essay argues that the orthodoxy is wrong. I, you, and the like are shifted by certain modal operators and hence can fail to refer to elements of the context, for example, I can fail to refer to the speaker. More precisely, indexicals are syntactically akin to logical variables. They can be free, in which case they work, (...) roughly, on the Kaplan model. But they can also be bound: this happens, in a systematic fashion, when they are in the scope of epistemic modals or attitude verbs. The new view has two interesting philosophical consequences. First, it vindicates a broadly Fregean perspective on referential expressions, essentially refuting the idea that indexicals are rigid designators. Second, it suggests a new picture of the interaction between context and linguistic meaning: compositional semantics does not need to look at the context and hence has no need for a context parameter. (shrink)

On a popular view dating back to Russell, descriptions, both definite and indefinite alike, work syntactically and semantically like quantifiers. I have an argument against Russell's view. The argument supports a different picture: descriptions can behave syntactically and semantically like variables. This basic idea can be implemented in very different systematic analyses, but, whichever way one goes, there will be a significant departure from Russell. The claim that descriptions are variables is not new: what I offer is a new way (...) of defending it. The argument centers on attitude reports. I argue that we should recognize a new reading of descriptions under attitude reports, which I call ‘singular opaque’. The existence of this reading cannot be explained on the traditional Russellian view, and demands a switch to the variable view. Along the way, some interesting new facts about attitude reports come to light. (shrink)

Anti-realist epistemic conceptions of truth imply what is called the knowability principle: All truths are possibly known. The principle can be formalized in a bimodal propositional logic, with an alethic modality ${\diamondsuit}$ and an epistemic modality ${\mathcal{K}}$, by the axiom scheme ${A \supset \diamondsuit \mathcal{K} A}$. The use of classical logic and minimal assumptions about the two modalities lead to the paradoxical conclusion that all truths are known, ${A \supset \mathcal{K} A}$. A Gentzen-style reconstruction of the Church–Fitch paradox is presented (...) following a labelled approach to sequent calculi. First, a cut-free system for classical bimodal logic is introduced as the logical basis for the Church–Fitch paradox and the relationships between ${\mathcal {K}}$ and ${\diamondsuit}$ are taken into account. Afterwards, by exploiting the structural properties of the system, in particular cut elimination, the semantic frame conditions that correspond to KP are determined and added in the form of a block of nonlogical inference rules. Within this new system for classical and intuitionistic “knowability logic”, it is possible to give a satisfactory cut-free reconstruction of the Church–Fitch derivation and to confirm that OP is only classically derivable, but neither intuitionistically derivable nor intuitionistically admissible. Finally, it is shown that in classical knowability logic, the Church–Fitch derivation is nothing else but a fallacy and does not represent a real threat for anti-realism. (shrink)

Pierre de Fermat is known as the inventor of modern number theory. He invented–improved many methods useful in this discipline. Fermat often claimed to have proved his most difficult theorems thanks to a method of his own invention: the infinite descent. He wrote of numerous applications of this procedure. Unfortunately, he left only one almost complete demonstration and an outline of another demonstration. The outline concerns the theorem that every prime number of the form 4n + 1 is the sum (...) of two squares. In this paper, we analyse a recent proof of this theorem. It is interesting because: it follows all the elements of which Fermat wrote in his outline; it represents a good introduction to all logical nuances and mathematical variants concerning this method of which Fermat spoke. The assertions by Fermat will also be framed inside their historical context. Therefore, the aims of this paper are related to the history of mathematics and to the logic of proof-methods. (shrink)

Part one: the act of speaking -- The speaker as performing artist -- The absolute performative -- The repetition of anthropogenesis -- Part two: toward a critic of interiority -- Second-degree sensualism: a physiognomic project -- In praise of reification -- Part three: from the beginning and right now -- Natural history -- The multitude and the principle of individuation -- Appendix: Wittgenstein and the question of atheism.

In the last decades, Systems Biology (including cancer research) has been driven by technology, statistical modelling and bioinformatics. In this paper we try to bring biological and philosophical thinking back. We thus aim at making diferent traditions of thought compatible: (a) causality in epidemiology and in philosophical theorizing—notably, the “sufcient-component-cause framework” and the “mark transmission” approach; (b) new acquisitions about disease pathogenesis, e.g. the “branched model” in cancer, and the role of biomarkers in this process; (c) the burgeoning of omics (...) research, with a large number of “signals” and of associations that need to be interpreted. In the paper we summarize frst the current views on carcinogenesis, and then explore the relevance of current philosophical interpretations of “cancer causes”. We try to ofer a unifying framework to incorporate biomarkers and omic data into causal models, referring to a position called “evidential pluralism”. According to this view, causal reasoning is based on both “evidence of diference-making” (e.g. associations) and on “evidence of underlying biological mechanisms”. We conceptualize the way scientists detect and trace signals in terms of information transmission, which is a generalization of the mark transmission theory developed by philosopher Wesley Salmon. Our approach is capable of helping us conceptualize how heterogeneous factors such as micro and macro-biological and psycho-social—are causally linked. This is important not only to understand cancer etiology, but also to design public health policies that target the right causal factors at the macro-level. (shrink)

Bringing together contributors from philosophy, international relations, security studies, and strategic studies, New Wars and New Soldiers offers a truly interdisciplinary analysis reflective of the nature of modern warfare. This comprehensive approach allows the reader to see the broad scope of modern military ethics, and to understand the numerous questions about modern conflict that require critical scrutiny. Aimed at both military and academic audiences, this paperback will be of significant interest to researchers and students in philosophy, sociology, military and strategic (...) studies, international relations, politics, and security studies, acting as an ideal course text or as supplementary reading. (shrink)

In this article, I draw upon the ‘post-Kantian’ reading of Hegel to examine the consequences Hegel’s idea of God has on his metaphysics. In particular, I apply Hegel’s ‘recognition-theoretic’ approach to his theology. Within the context of this analysis, I focus especially on the incarnation and sacrifice of Christ. First, I argue that Hegel’s philosophy of religion employs a distinctive notion of sacrifice (kenotic sacrifice). Here, sacrifice is conceived as a giving up something of oneself to ‘make room’ for the (...) other. Second, I argue that the idea of kenotic sacrifice plays a fundamental role in Hegel’s account of Christ. Third, I conclude by sketching some of the consequences of Hegel’s idea of a God who renounces his own divinity for an idealistically conceived metaphysics. My main thesis is that the notion of incarnation is conceived by Hegel as the expression of a spirit that advances only insofar as it is willing to withdraw and make room for the other. A kenotic reading of the Hegelian notion of the incarnation is also useful in terms of a clarification of the dispute between ‘left Hegelians’ and ‘right Hegelians’ concerning the status of the idea of God in Hegel’s philosophy. (shrink)

Can we build endogenous expectations about the locus of occurrence of a target without being able to describe them? Participants performed cue–target detection tasks with different proportions of valid and invalid trials, without being informed of these proportions, and demonstrated typical endogenous effects. About half were subsequently able to correctly describe the cue–target relationships . However, even non-verbalizer participants showed endogenous orienting with peripheral cues , not depending solely on practice . Explicit instructions did not bring about dramatic advantages in (...) performance .With central symbolic cues, only verbalizers showed reliable endogenous effects . We concluded that endogenous orienting with peripheral cues can occur independently of participants developing explicit hypotheses about the cue–target relationships. (shrink)

In his book Semantic Relationism, Kit Fine propounds an original and sophisticated semantic theory called ‘semantic relationism’ or ‘relational semantics’, whose peculiarity is the enrichment of Kaplan’s, Salmon’s and Soames’ Russellian semantics (more specifically, the semantic content of simple sentences and the truth-conditions of belief reports) with coordination, “the very strongest relation of synonymy or being semantically the same”. In this paper, my goal is to shed light on an undesirable result of semantic relationism: a report like “Tom believes that (...) Cicero is bald and Tom does not believe that Tully is bald” is correct according to Fine’s provided truth-conditions of belief reports, but its semantic content is (very likely) a contradiction. As I will argue in the paper, even the resort to the notion of token proposition, introduced in Fine’s recent article “Comments on Scott Soames’ ‘Coordination Problems’”, does not suffice to convincingly eliminate the contradiction; moreover, it raises new difficulties. (shrink)

In this paper the PA-completeness of modal logic is studied by syntactical and constructive methods. The main results are theorems on the structure of the PA-proofs of suitable arithmetical interpretationsS of a modal sequentS, which allow the transformation of PA-proofs ofS into proof-trees similar to modal proof-trees. As an application of such theorems, a proof of Solovay's theorem on arithmetical completeness of the modal system G is presented for the class of modal sequents of Boolean combinations of formulas of the (...) form p i,m i=0, 1, 2, ... The paper is the preliminary step for a forthcoming global syntactical resolution of the PA-completeness problem for modal logic. (shrink)

In this paper, I propose the idea that the French mathematician Michel Chasles developed a foundational programme for geometry in the period 1827–1837. The basic concept behind the programme was to show that projective geometry is the foundation of the whole of geometry. In particular, the metric properties can be reduced to specific graphic properties. In the attempt to prove the validity of his conception, Chasles made fundamental contributions to the theory of polarity and also understood that a satisfactory development (...) of projective geometry has to overcome the specificity of that theory itself. In this perspective, he developed his ideas on duality and homography, showing their dependence on the concept that he was going to pose at the basis of geometry: the anharmonic ratio, today called cross-ratio. The conceptual itinerary that starts from Chasles’ studies on polarity and ends with his results based on the cross-ratio represents the itinerary of his foundational programme. I will follow this complex and interesting line of thought, place it in the context of what was then called descriptive geometry, and outline a connection with the later great results of Von Staudt, Cayley, and Klein. (shrink)

La struttura a livelli modella il tutto e le sue parti con grande generalità. Lo dimostrano le argomentazioni teoriche (4.3), (4.4) e (4.5), e lo comprova la casistica che è stata aggiunta. Una tale struttura non presenta affatto i problemi a), b) e c) che sono tipici della struttura ad albero. Essa corregge inoltre deviazioni concettuali che sono diffuse nel settore informatico. L’immediatezza deviazioni concettuali che sono diffuse nel settore informatico. L’immediatezza visiva, infine, ne facilita la diffusione sul piano professionale (...) e tecnico.Per concludere, ritengo che la struttura a livelli possa fornire un contributo anche alle ricerche di ontologia e in particolare possa favorire i tentativi di unificazione condotti sia sul piano teorico, sia su quello applicativo [Uschold 1996]. Le difficoltà ed i limiti che la teoria degli insiemi oppone ad un formalismo generale (ad esempio quando riduce la casistica della relazione concetto di livello possiede una valenza estremamente ampia e ciò lo predispone per gli auspicati sviluppi ontologici. (shrink)

In this study some typical aspects of human behavior are reconsidered in a new evolutionary perspective. Firstly, a theoretical paradigm is introduced, according to which animals show a natural propensity to maintain behavior far beyond the time when the triggering motivation has been removed;, these drifting conducts are defined as Vestigial Drifting Drives or. Such a paradigm is then applied to those human attitudes that once conferred an adaptive advantage on our species but have now become dysfunctional within the framework (...) of the current ecological crisis. In this context, human beings are considered the repository of VDDs that may play out as evolutionary threats. This thesis is supported by many examples and references that, hopefully, could stimulate scientific debate and further research in evolutionary anthropology, psychology, and related disciplines. (shrink)

The two theories of pancreatic enzyme secretion, those of exocytosis and transmembrane flow, are described. Data thought to support the theory of transmembrane flow of single molecules from pancreatic acinar cells are first reviewed, and the conditions which could allow these data to be explained by the theory of exocytosis of enzyme quanta, i.e. secretory granules, are then discussed.The evidence suggesting short‐term modulation of the composition of pancreatic juice is also considered, and its possible explanations at the organ and cellular (...) level are discussed, in the light of suggested theories on enzyme secretion pathways. (shrink)

L’articolo si pone il problema del perché Vico avesse pensato alla sua impresa come ad una scienza e si fosse occupato di confrontarla con la scienza della natura. Si passano in rassegna l’uso di concetti come degnità, assiomi, postulati, tenendo fermo che Vico non fu né un cartesiano, né un galileiano, e come non si lasci racchiudere nelle gabbie dell’apriorismo e del platonismo: egli ha solo fatto sue alcune idee o tesi presenti entro quelle tradizioni. Vico si guarda bene dall’effettuare (...) una scelta precisa e definitiva tra quelle realtà alle quali attribuiamo oggi il nome di razionalismo e empirismo. Si richiama contemporaneamente e negli stessi testi sia alla tradizione del geometrismo cartesiano sia a quella di Bacone e delpensiero dei baconiani del tardo Seicento, facendone un uso alquanto libero. L’articolo contiene inoltre osservazioni su Vico lettore di Cogitata et visa e di De dignitate et augmentis scientarum di Bacone. (shrink)

[Patañjali, Yogasūtras with Bhoja’s Rājamārtaṇḍa Commentary. With an Introduction, Translation, Subcommentary and Notes by Paolo Magnone].

Forms of contemporary life attest to the dissolution of the concept of the ‘people’ and the renewed importance of the idea of the ‘multitude’. Though they took center stage in the seventeenth century debate that spawned much of our ethico-political lexicon, these two notions are polar opposites. The ‘people’ is by its very nature centripetal. Converging towards a general will, it acts as an interface between citizens and the State. The ‘multitude’ is plural. Fleeing all political unity, it shuns negotiations (...) with the sovereign and refuses to delegate its rights to that power; it is a recalcitrant and disobedient entity with a taste for certain forms of non-representative democracy. For example, Hobbes claims that citizens in rebellion against the State represent “the multitude against the people.” But while Hobbes spotted the greatest hindrance to the workings of the State within this multitude, Spinoza found in it the roots of liberty. The political existence of ‘multiples’ as such has been stricken from the horizon of modernity: not only by Absolute State theorists, but also by Rousseau, the liberal tradition, and the socialist movement itself. (shrink)

In his third essay on earthquakes, Kant refers to “Pater Bina’s” electric interpretation of seismic phenomena. Although not a distinguished scholar, and maybe for that reason frequently confused with a certain “Father Isidore Binet”, Bina was nevertheless a noteworthy author. A Cassinese benedictine, Andrea Bina was a philosopher interested in sciences just like Kant; he studied Newton, translated Wolff, invented a seismoscope and was appreciated by his contemporaries at home and beyond the Alps. Kant’s laconic quotation, followed by a value (...) judgement regarding only Bina’s “audacity”, raises some questions, including, in primis those about the meaning of his hasty judgment. A plausible well-grounded answer should be looked for in the bio-bibliographical outline of the neglected author and in the perusal of his writings. The analysis of Bina’s Ragionamento sopra le cagioni de’ terremoti (1751) contributes to our knowledge of the eighteenth-century cultural background and helps us understand the degree of knowledge of the seismic phenomena acquired by men who – amidst many difficulties and hindered by the limits of their science – could only rely on secondhand data often imbued with misconceptions. Comparing Bina’s work – although indirectly – with Kant’s Fortgesetzte Betrachtung der seit einiger Zeit wahrgenommenen Erderschütterungen (1756) may help bring to light some convergences, as well as differences, which might be of use in clarifying some peculiarities of the Prussian Naturforscher. (shrink)

In this article we explore how multinational corporations (MNCs) adopt assurance practices to develop and sustain organizational accountability for sustainability. Using a panel of Fortune Global 250 firms over a period of 10 years, we document the diffusion patterns of third-party assurance of sustainability reports. We specifically investigate how evolving auditing practices, namely diversity of assurance standards and type of assurance providers, shape the quality of sustainability assurance statements. The results illustrate great variability in the adoption of assurance practices in (...) the formative stages of this novel market. Our descriptive analysis indicates the relevance of external institutional pressure as well as internal resources and capabilities as underlying factors driving the adoption of assurance. Our evidence also suggests that several MNCs project a decoupled or symbolic image of accountability through assurance, thereby undermining the credibility of these verification practices. The paper contributes to the emerging literature on international accountability standards and emphasizes the need to enhance theory-based, cross-disciplinary knowledge related to auditing and accountability processes for sustainability. (shrink)

The homeopathic principle of similitude is not based on the principle of vaccination but on the more general principle of inversion of effects, a widespread medical phenomenon. Based on the systemic networks which play an important role in response to stress, this principle concerns the reorganization of regulation systems, through a coherent response to the medicine. This model is backed by a large number of published studies from our laboratory and others, by toxicological evidence such as the emerging fields of (...) ‘hormesis’, of neuropharmacology, and of systems biology. The immune system is just one example of the possible application of this law of similitude, which constitutes the true ‘heart’ of the homeopathic idea, and again ethically justifies the attempt to apply it to experimental pharmacology. (shrink)

This paper addresses the role of the notion of sacrifice in Kant’s theoretical philosophy, practical philosophy, and in his account of religion. First, I argue that kenotic sacrifice, or sacrifice as ‘withdrawal’, plays a hidden and yet important role in the development of Kant’s transcendental philosophy. Second, I focus on Kant’s practical philosophy, arguing that the notion of sacrifice that is both implied and explicitly analyzed by Kant is mainly suppressive sacrifice. However, Kant’s account is fundamentally ambiguous, as sometimes the (...) kenotic meaning of sacrifice seems to resurface, especially in the context of Kant’s discussion of the happiness of others as an end in itself. Because religious notions are regarded by Kant as necessary transitional forms (Darstellungen) to be used to make moral ideas applicable to the world, I then scrutinize Kant’s view of sacrifice as an improper symbol, and I analyze Kant’s arguments for such a dismissal and discuss the subject matter in recent literature. Finally, I examine the role of sacrifice in Kant’s account of Christ as the prototype of pure moral disposition. I conclude by arguing that Kant indeed grasped the importance of including kenotic dynamics in practical philosophy but was somehow unable or unwilling to integrate it into the formal grounding of his ethics. This tension, however, effectively provides an entry point for features that can be found in the post-Kantians. (shrink)