The mature cerebral cortex contains a staggering variety of projection neuron subtypes, and a number of complementary studies have recently begun to define their identity and embryonic origin. Among the different types of cortical projection neurons, subcerebral projection neurons, including corticospinal motor neurons (CSMN), have been extensively studied and some of the molecular controls over their differentiation have been elucidated. Here, we first provide an overview of the approaches used to purify and molecularly profile neuronal populations of the neocortex and, (...) more broadly, of the central nervous system (CNS). Next, we specifically review recent progress in understanding the genes that define and control development of the CSMN population. Finally, we briefly discuss the relevance of this work to current questions regarding the mechanisms of the establishment of projection neuron subtype identity in the neocortex and its implications to direct the differentiation of CSMN for therapeutic benefit. (shrink)

How much do animals matter--morally? Can we keep considering them as second class beings, to be used merely for our benefit? Or, should we offer them some form of moral egalitarianism? Inserting itself into the passionate debate over animal rights, this fascinating, provocative work by renowned scholar Paola Cavalieri advances a radical proposal: that we extend basic human rights to the nonhuman animals we currently treat as "things." Cavalieri first goes back in time, tracing the roots of the debate (...) from the 1970s, then explores not only the ethical but also the scientific viewpoints, examining the debate's precedents in mainstream Western philosophy. She considers the main proposals of reform that recently have been advanced within the framework of today's prevailing ethical perspectives. Are these proposals satisfying? Cavalieri says no, claiming that it is necessary to go beyond the traditional opposition between utilitarianism and Kantianism and focus on the question of fundamental moral protection. In the case of human beings, such protection is granted within the widely shared moral doctrine of universal human rights' theory. Cavalieri argues that if we examine closely this theory, we will discover that its very logic extends to nonhuman animals as beings who are owed basic moral and legal rights and that, as a result, human rights are not human after all. (shrink)

We invited five Cavell scholars to write on this topic. What follows is a vibrant exchange among Paola Marrati, Andrew Norris, Jörg Volbers, Cary Wolfe and Thomas Dumm addressing the question whether, in the contemporary political context, Cavell’s skepticism and his Emersonian perfectionism amount to a politics at all.

Este trabajo de investigación se ocupa de un análisis sociocrítico de la puesta en forma de la novela Auto de fe del escritor austriaco Elías Canetti. El análisis se centra en el tratamiento crítico de la realidad y la visión desesperanzada que Canetti objetiva en la obra sobre los procesos de modernidad. Elías Canetti, desde una posición realista crítica, evalúa descarnadamente la confianza ciega en el ideal ilustrado, a partir de una modernidad exacerbada que se materializa en la axiología del (...) héroe problemático. (shrink)

Although remote working can involve positive outcomes both for employees and organizations, in the case of the sudden and forced remote working situation that came into place during the COVID-19 crisis there have also been reports of negative aspects, one of which is technostress. In this context of crisis, leadership is crucial in sustainably managing and supporting employees, especially employees with workaholic tendencies who are more prone to developing negative work and health outcomes. However, while research on the role of (...) the positive aspects of leadership during crises does exist, the negative aspects of leadership during the COVID-19 crisis have not yet been studied. The present study aimed to explore the role of authoritarian leadership in a sample of 339 administrative university employees who worked either completely from home or from home and the workplace. The study examined the moderating effect of a manager on this relationship and the connections between workaholism and technostress through conditional process analysis. Results pointed out that high authoritarian leadership had an enhancing effect, whereas low authoritarian leadership had a protective effect on the relationship between workaholism and technostress, only in the group of complete remote workers. Thus, authoritarian leadership should be avoided and training leaders to be aware of its effect appears to be essential. Limitations, future directions for the study, and practical implications are also discussed. (shrink)

In this study, Paola Marrati approaches—in an extremely insightful, rigorous, and well-argued way—the question of the philosophical sources of Derrida's thought through a consideration of his reading of both Husserl and Heidegger. A central focus of the book is the analysis of the concepts of genesis and trace as they define Derrida's thinking of historicity, time, and subjectivity. Notions such as the contamination of the empirical and the transcendental, dissemination and writing, are explained as key categories establishing a guiding (...) thread that runs through Derrida's early and later works. Whereas in his discussion of Husserl Derrida problematizes the relationship between the ideality of meaning and the singularity of its historical production, in his interpretation of Heidegger he challenges the very idea of the originary finitude of temporality. This book is essential reading not only for those interested in the philosophical roots of deconstruction, but for all those interested in the central questions of history and temporality, subjectivity and language, that pervade contemporary debates in cultural, literary, and visual theory alike. (shrink)

While moral perfectionists rank conscious beings according to their cognitive abilities, Paola Cavalieri launches a more inclusive defense of all forms of subjectivity. In concert with Peter Singer, J. M. Coetzee, Harlan B. Miller, and other leading animal studies scholars, she expands our understanding of the nonhuman in such a way that the derogatory category of "the animal" becomes meaningless. In so doing, she presents a nonhierachical approach to ethics that better respects the value of the conscious self. Cavalieri (...) opens with a dialogue between two imagined philosophers, laying out her challenge to moral perfectionism and tracing its influence on our attitudes toward the "unworthy." She then follows with a roundtable "multilogue" which takes on the role of reason in ethics and the boundaries of moral status. Coetzee, Nobel Prize winner for Literature and author of _The Lives of Animals_, emphasizes the animality of human beings; Miller, a prominent analytic philosopher at Virginia Polytechnic Institute, dismantles the rationalizations of human bias; Cary Wolfe, professor of English at Rice University, advocates an active exposure to other worlds and beings; and Matthew Calarco, author of _Zoographies: The Question of the Animal from Heidegger to Derrida_, extends ethical consideration to entities that traditionally have little or no moral status, such as plants and ecosystems. As Peter Singer writes in his foreword, the implications of this conversation extend far beyond the issue of the moral status of animals. They "get to the heart of some important differences about how we should do philosophy, and how philosophy can relate to our everyday life." From the divergences between analytical and continental approaches to the relevance of posthumanist thinking in contemporary ethics, the psychology of speciesism, and the practical consequences of an antiperfectionist stance, _The Death of the Animal_ confronts issues that will concern anyone interested in a serious study of morality. (shrink)

The present study aims at exploring whether the level of well-being vary as a function of fertility status in different phases of the ovulatory cycle. We investigated the multidimensional well-being, including the cognitive component of subjective well-being related to judgments about one’s life satisfaction, the psychological well-being concerning the full growth and self-realization of the individual, and self-esteem, that is the personal judgment of overall self-worth and is recognized as one indicator of well-being. On the basis of the cycle phase (...) estimation at the moment of the experiment, one hundred and sixteen normally cycling women were divided into “fertile” and “non-fertile” groups and were administered the Psychological Well-Being Scale, the Basic Self-Esteem Scale and the Satisfaction with Life Scale. A Multivariate Analysis of Variance has been performed to examine whether there were differences between groups according to their ovulatory phase. All dimensions of psychological well-being, self-esteem and satisfaction with life were found to be stable in the different phases of the menstrual cycle. The implications of these results are discussed. (shrink)

This text was first published in Theory, Culture & Society, May 13, 2015. For a special issue of Body & Society on ‘Rhythm, Movement, Embodiment', Paola Crespi presents two previously untranslated texts, Rudolf Bode's ‘Rhythm and its Importance for Education' and Rudolf Laban's ‘Eurhythmy and Kakorhythmy'. In the following interview she uncovers further unpublished and untranslated sources and she discusses some of the main themes of these texts in relation to the more widely known text - Danse, théâtre et (...) spectacle vivant – GALERIE – Nouvel article. (shrink)

In this paper, we propose meaningfulness as one important evaluative criterion in individual climate ethics and suggest that most of our greenhouse gas emitting actions, behaviours, and lives are the opposite of meaningful: anti-meaningful. We explain why such actions etc. score negatively on three important dimensions of the meaningfulness scale, which we call the agential, narrative, and generative dimensions. We suggest that thinking about individual climate ethics also in terms of (anti-) meaningfulness illuminates important aspects of our troubled ethical involvement (...) with CC and can make a fresh and fruitful contribution to existing discussions, which tend to focus on moral responsibility and obligations. (shrink)

This book takes the reader on a philosophical quest to understand the dark side of emotions. The chapters are devoted to the analysis of negative emotions and are organized in a historical manner, spanning the period from ancient Greece to the present time. Each chapter addresses analytical questions about specific emotions generally considered to be unfavorable and classified as negative. The general aim of the volume is to describe the polymorphous and context-sensitive nature of negative emotions as well as changes (...) in the ways people have interpreted these emotions across different epochs. The editors speak of ‘the dark side of the emotions’ because their goal is to capture the ambivalent – unstable and shadowy – aspects of emotions. A number of studies have taken the categorial distinction between positive and negative emotions for granted, suggesting that negative emotions are especially significant for our psychological experience because they signal difficult situations. For this reason, the editors stress the importance of raising analytical questions about the valence of particular emotions and focussing on the features that make these emotions ambivalent: how – despite their negativity – such emotions may turn out to be positive. This opens up a perspective in which each emotion can be understood as a complex interlacing of negative and positive properties. The collection presents a thoughtful dialogue between philosophy and contemporary scientific research. It offers the reader insight by illuminating the dark side of the emotions. (shrink)

Was ist ein Einzelding? Gibt es ein erstes und letztes Prinzip, das erlaubt, etwas als Einzelnes und Eines anzusprechen? Lasst sich das Einzigartige und Einmalige mit den Mitteln des Denkens erfassen? Ist menschliche Individualitat ein Apriori oder eine empirische Konstruktion? Die Untersuchung erschliesst ontologische und ethische Grundzuge der Individuationsfrage im Gesprach mit drei ihrer Hauptstationen, die ihrerseits in einem dichten Geflecht von Verweisen, Anknupfungen und Anverwandlungen stehen. Sie kann als Beitrag zur Individuationstheorie wie auch als problemorientierte Einfuhrung in die behandelten (...) Positionen gelesen werden.Nietzsches Individuationsgedanke wird einerseits im Willen zur Macht als dem ontologischen principium individuationis der perspektivisch zerstreuten Realitat geortet, andererseits - anhand einer Neulekture zentraler Nachlass-Stellen - in dem abgrundlichsten Gedanken der ewigen Wiederkunft des Gleichen, der eine ethische (im Sinne Nietzsches: esoterische) Selbstpositionierung des Menschen vor dem Ganzen des Seienden erfordert.Als zweite Station erortert die Untersuchung Leibnizens monadologische Theorie einer absoluten Individualitat in ihren ontologischen Wesenszugen und im Hinblick auf das daraus erwachsende moralische Postulat einer universellen Harmonie, mit dem Leibniz die unter umgekehrten Vorzeichen auch Nietzsches Denken umtreibende Frage nach dem ontologisch-ethischen Verhaltnis von Perspektivitat und (moglicher oder negierter) Totalitat beantwortet.Mit der Thematisierung des aristotelischen Individuationsgedankens wird die Individuationsfrage in ihren massgeblich gewordenen Ursprung zuruckverfolgt. Besprochen werden u.a. die Frage nach der Bestimmbarkeit des Einzeldings als erster ousia, die entelechiale Wesensverfassung des Lebens, die Struktur des bestimmend-eingrenzenden logos sowie die Moglichkeit einer ethischen Selbstindividuation des Menschen im Spiel von Entgrenzung und Selbsthaltung. (shrink)

The aim of the article is to analyze the double movement around the legal construct “Señor Natural” that takes place in Las Siete Partidas by Alfonso X, a key concept in the wise King’s political program. On the one hand, the concept of “Señor natural” is reworked and becomes legal, placing the king above any other order; on the other, the obligation regarding the “Señor natural” is established as the best of all “natural obligations”. All this conflates into a new (...) concept of “Señor natural” based on men and the land, which becomes a natural obligation in Partidas, a monarch’s reinforcement to exercise dominium in the totality of the kingdom. (shrink)

In this paper, we examine the problems facing a policy maker who observes inconsistent choices made by agents who are boundedly rational. We contrast a model-less and a model-based approach to welfare economics. We make the case for the model-based approach and examine its advantages as well as some problematic issues associated with it.

The paper discusses some difficulties that life in Anthropocene poses to our ethical thinking. It describes the sort of ethical task that individuals find themselves confronting when dealing with the planetary environmental quandaries that characterise the new epoch. It then asks what, given the situation, would count as environmentally virtuous ways of looking at and going about our lives, and how relevant virtues can be developed. It is argued that the practice of gardening is distinctively conducive to that objective. Finally, (...) some garden virtues that will be of special importance in the Anthropocene, but have so far been largely neglected by environmental ethicists, are listed and described. (shrink)

The article evaluates the Domain Postulate of the Classical Model of Science and the related Aristotelian prohibition rule on kind-crossing as interpretative tools in the history of the development of mathematics into a general science of quantities. Special reference is made to Proclus’ commentary to Euclid’s first book of Elements , to the sixteenth century translations of Euclid’s work into Latin and to the works of Stevin, Wallis, Viète and Descartes. The prohibition rule on kind-crossing formulated by Aristotle in Posterior (...) analytics is used to distinguish between conceptions that share the same name but are substantively different: for example the search for a broader genus including all mathematical objects; the search for a common character of different species of mathematical objects; and the effort to treat magnitudes as numbers. (shrink)

Gilles Deleuze est le premier philosophe français (et l'un des très rares dans le monde) à avoir consacré l'intégralité d'un ouvrage de philosophie au cinéma. S'étant fixé comme objectif de penser le cinéma dans sa singularité, à la fois comme pratique artistique et comme pensée, le philosophe s'est trouvé conduit à reconsidérer certains aspects fondamentaux de son projet philosophique, et à produire des concepts nouveaux. Une synthèse claire et concise.

This paper describes the disorienting aesthetics of some environments that are characteristic of the Anthropocene. We refer to these environments as ‘mashed-up’ and present three dimensions – phenomenological, epistemological and narrative – of the aesthetic disorientation they can trigger. We then advance the suggestion that a rich, nuanced and meaningful aesthetic experience of mashed-up Anthropocene environments (MAEs) calls for a mode of appreciation grounded on performative practices of aesthetic familiarisation with particular MAEs and entities and processes thereof. Familiarisation with MAEs, (...) we further note, can have disorienting codas of its own. It can reveal and highlight, rather than eliminate or alleviate, the solid strangeness of Earth even in the systemically humanised world of the Anthropocene, and it can expose and tie at least some of our agency, identity and sources of meaning in life to the same unstable evolvability of particular MAEs. (shrink)

The depths of the sea, their obscure inhabitants and their mysteries have always been a rich source of myths and metaphors for authors and philosophers. Fables about giant squids and monstrous octopuses run through the history of literature and culture. The vampire squid is only a small phylogenetic relic, but it provides a useful model for Flusser's hybrid philosophical fiction Vampyroteuthis Infernalis. Flusser slips metaphorically into the creature’s gelatinous skin in order to speculate on the paradigms of postmodern life, measuring (...) the abyss from the inside and producing a very peculiar, experimental form of thinking and writing. In the present era of virtual reality and computer simulations, we experience fiction as the only reality. According to Vaihinger's definition, fiction is a useful construct that is precisely not real, but enables human beings to create and manipulate their environments. His philosophy of “as if” is perhaps the fullest expression of fictionalism and shows its ambivalent potential. (shrink)

Lejos de la interpretación de Leon Battista Alberti como prototipo del "hombre universal", GARIN ha reconocido el carácter contradictorio del pensamiento albertiano. En efecto, en la extensa y polifacética obra del humanista genovés coexisten dos visiones antagónicas del hombre y el mundo. A una le corresponde la confianza en la razón, a la otra la constatación del carácter absurdo de la existencia. Este Alberti "sombrío" se expresa en las páginas de Momus y las Intercenales. En ellas, la apelación a una (...) existencia simulada es abordada a través de una risa desacralizadora del ideal humano que alumbró el temprano Renacimiento italiano. Far from the interpretation of Leon Battista Alberti as a prototype of the "universal man", GARIN has analyzed the contradictory nature of Alberti's thought. In fact, in the extensive and versatile work of the Genoese humanist two opposite visions of man and the world coexist: one believes in the power of reason, the other acknowledges the absurdity of life. It is in Momus and the Intercenales that this "somber Alberti" is present. In these texts the appeal to a simulated life is addressed through a form of laughter that demystifies the human ideal of the early Italian Renaissance. (shrink)

Una de las matrices que opera en la construcción roigeana de la Historia de las ideas latinoamericanas radica en la intención de seguir afirmando y haciendo explícito el “sentido” desde el cual se organiza, precisamente, el “a priori antropológico”, el que determina el valor axiológico como imposibl..

En el siguiente documento se presentará una síntesis de las ideas centrales que arguye Antonin Artaud en su obra: El teatro y su doble para establecer, en la discusión sobre el arte, la idea del artista como un héroe desde una perspectiva ontológica, que no implica simplemente las representaciones sensibles de los héroes figurativos de las tradicionales obras trágicas. En esta nueva categorización, el artista se considerará como héroe teniendo en cuenta tres ejes fundamentales: primero, la relación espiritualidad-corporalidad; segundo, la (...) noción de crisis de la cultura como factor esencial en la constitución de un arte metafísico; y tercero, la idea de crueldad del arte como respuesta a lo que presenta el mundo. (shrink)