One of the surprises from genome sequencing projects is the apparently small number of predicted genes in different eukaryotic cells, particularly human. One possible reason for this ‘shortage’ of genes is multiple distribution of proteins; a single protein is targeted to more than one subcellular compartment and consequently participates in different biochemical pathways and might have completely different functions. Indeed, in recent years, there have been reports on proteins that were found to be localized in cellular compartments other than those (...) initially attributed to them. Furthermore, the phenomenon of highly uneven isoprotein distribution was recently observed and termed ‘eclipsed distribution’. In these cases, the amount of one of the isoproteins, in one of the locations, is significantly minute and its detection by standard biochemical and visualization methods is masked by the presence of the dominant isoprotein. In fact, the minute amounts of eclipsed proteins can be essential. Since detecting eclipsed distribution is difficult, we assume that this phenomenon is probably more common than currently recorded. Hence, developing methods for localization and functional detection of eclipsed proteins is a challenge in cell biology research. Finally, eclipsed distribution may lead to cellular pathologies as has been suggested to occur in human disorders such as Prion diseases and Alzheimer. This review provides a short description of the eclipsed distribution phenomenon followed by an overview of protein distribution mechanisms, examples of eclipsed distribution and experimental approaches for revealing these elusive proteins. BioEssays 29:772–782, 2007. © 2007 Wiley Periodicals, Inc.. (shrink)

This ambitious book looks into the reasons for the exceptional durability of the Chinese empire, which lasted for more than two millennia (221 B.C.E. - 1911 C.E.). Yuri Pines identifies the roots of the empire's longevity in the activities of thinkers of the Warring States period (453-221 B.C.E.), who, in their search for solutions to an ongoing political crisis, developed ideals, values, and perceptions that would become essential for the future imperial polity. In marked distinction to similar empires worldwide, (...) the Chinese empire was envisioned and to a certain extent 'preplanned' long before it came into being. As a result, it was not only a military and administrative construct, but also an intellectual one. Pines makes the argument that it was precisely its ideological appeal that allowed the survival and regeneration of the empire after repeated periods of turmoil. "Envisioning Eternal Empire" presents a panoptic survey of philosophical and social conflicts in Warring States political culture. By examining the extant corpus of preimperial literature, including transmitted texts and manuscripts uncovered at archaeological sites, Pines locates the common ideas of competing thinkers that underlie their ideological controversies. This bold approach allows him to transcend the once fashionable perspective of competing 'schools of thought' and show that beneath the immense pluralism of Warring States thought one may identify common ideological choices that eventually shaped traditional Chinese political culture. The result is a refreshingly novel look at the foundational period in Chinese intellectual history. (shrink)

_Ideology of Power and Power of Ideology in Early China_ explores Chinese political thought during the centuries surrounding the formation of the empire in 221 BCE, examining devices of legitimation, views of rulers and ministers, economic thought, and administrative practices.

This article surveys the usages of the term de 德 in the Zuozhuan《左傳》. It demonstrates the term’s hermeneutical richness: de could refer to charismatic power, to political potency, to proper decorum, to mildness and kindness in domestic or interstate affairs, to individual morality, and so forth. Behind this richness, though, we may discern a clear predominance of political usages of de and paucity of references to de as personal moral virtue. Notably, Zuozhuan never refers to de in the context of (...) moral self-cultivation. The article discusses the reasons for this peculiarity. (shrink)

The Spring and Autumn Annals of Master Yan. Translated and annotated by Olivia Milburn. Sinica Leidensia, vol. 128. Leiden: Brill, 2016. Pp. xxx + 485. €161, $193.

This monument of rabbinical exegesis written at the end of the twelfth century has exerted an immense and continuing influence upon Jewish thought. Its aim is to liberate people from the tormenting perplexities arising from their understanding of the Bible according only to its literal meaning. This edition contains extensive introductions by Shlomo Pines and Leo Strauss, a leading authority on Maimonides.

: Because an influenza pandemic would create the most serious hardships for those who already face most serious hardships, countries should take special measures to mitigate the effect of a pandemic on existing social inequalities. Unfortunately, there is little evidence that anybody is thinking about that.

"Williams's masterful translation satisfies (at last!) a long-standing need. There are lots of good translations of Augustine's great work, but until now we have been forced to choose between those that strive to replicate in English something of the majesty and beauty of Augustine's Latin style and those that opt instead to convey the careful precision of his philosophical terminology and argumentation. Finally, Williams has succeeded in capturing both sides of Augustine's mind in a richly evocative, impeccably reliable, elegantly readable (...) presentation of one of the most impressive achievements in Western thought--Augustine's Confessions." --Scott MacDonald, Professor of Philosophy and Norma K. Regan Professor in Christian Studies, Cornell University. (shrink)

Essential Logic offers: BL Readability. A dialogue-like yet challenging style makes this introductory logic textbook engaging and interesting. BL Essentials. Deductive and inductive reasoning, formal and informal logic are placed within a philosophical perspective. BL Rigor. A careful sequence of learning steps communicates the essential skills of reasoning and directs students to write, support, and argue by connecting criticism to key concepts. BL Relevance. Explanations and examples take students' lives into consideration and are designed for students with diverse backgrounds and (...) a wide range of experiences. BL A Theme. Traditional concepts are integrated with a discussion of modern technological issues and the world view of modern science. A unique chapter on Logic and Hope addresses questions students often ask and suggests a global perspective. BL Controversy. Students are encouraged to defend and critique positions--including those presented by the author. A unique final chapter on Fuzzy Logic is framed as a debate between Western and Eastern philosophy. BL Exercises. Students gain confidence in recognizing arguments, structuring them into premises and conclusions, identifying and critiquing informal fallacies, while learning to create, follow, and appreciate symbolic reasoning trails. BL Coverage. Chapters cover Argument Recognition and Language Analysis, Inductive Reasoning, Structuring Informal Fallacies, Symbolic Translation, Truth Tables, Formal Proofs of Validity, Quantification, and the basics of Fuzzy Set Theory and Propositional Logic. (shrink)

ABSTRACTThe Book of Lord Shang attributed to Shang Yang is one of the most controversial products of ideological debates in pre-imperial China. Forty years ago, Li Yu-ning summarized previous rounds of debates that peaked with the Shang Yang fervor of the early 1970s. The present article takes over where she ended, further exploring trends in studies of the Book of Lord Shang since the Open-up-and-Reform Era. The paper shows that despite a clear tendency of depoliticization of these studies, scholars are (...) still deeply influenced by the tradition of using the figure of Shang Yang as a foil in contemporary political debates. In their evaluation of Shang Yang’s legacy, many contemporary Chinese scholars continue to use traditional views, but also modern ideas such as the “rule of law,” “progress,” “evolution,” “dialectic,” or the Marxist theory of distinct social stages. They all contribute to the ongoing relevance of Lord Shang to current China. (shrink)

This introduction surveys the biography and major works of Liu Zehua, a leading scholar of China's intellectual history, political thought, and political culture. It explores the impact of Liu Zehua's personal experience, in particular the upheavals of the Cultural Revolution, on his conceptualization of Chinese political culture as subjugated to the overarching principle of monarchism. Liu Zehua's critical engagement with China's past distinguishes him from proponents of revival of traditional values and makes him one of the powerful opponents of cultural (...) conservatives in China. (shrink)

Studies in the philosophy of Abul-Barak t al-Baghd d (R), deals with various aspects of the philosophy of Abul-Barak t al-Baghd d (R). Some of Avicennas physical and psychological doctrines are also discussed.

Shlomo Pines The Philosophical Purport of Maimonides' Halachic Works and the Purport of The Guide of the Perplexed Maimonides' principal halachic works, ...

Having translated The Diamond Sutra and The Heart Sutra, and following with The Platform Sutra, Red Pine now turns his attention to perhaps the greatest Sutra of all. The Lankavatara Sutra is the holy grail of Zen. Zen's First Patriarch, Bodhidharma, gave a copy of this text to his successor, Hui-k'o, and told him everything he needed to know was in this book. Passed down from teacher to student ever since, this is the only Zen sutra ever spoken by the (...) Buddha. Although it covers all the major teachings of Mahayana Buddhism, it contains but two teachings: that everything we perceive as being real is nothing but the perceptions of our own mind and that the knowledge of this is something that must be realized and experienced for oneself and cannot be expressed in words. In the words of Chinese Zen masters, these two teachings became known as "have a cup of tea" and "taste the tea." This is the first translation into English of the original text used by Bodhidharma, which was the Chinese translation made by Gunabhadra in 443 and upon which all Chinese Zen masters have relied ever since. In addition to presenting one of the most difficult of all Buddhist texts in clear English, Red Pine has also added summaries, explanations and notes, including relevant Sanskrit terms on the basis of which the Chinese translation was made. This promises to become an essential text for anyone seeking to deepen their understanding or knowledge of Zen. (shrink)

This volume covers some fifty years of Pines' work in the field of Islamic philosophy, from the very first article he published ("Some Problems of Islamic Philosophy", in 1937") to an article that was found in his paper after his death and is published here for the first time (" The origin of the Tale of Salâmân and Absâl").

The late Shlomo Pines (1908-1990) was this century's outstanding historian of Islamic philosophy and science. This volume offers, for the first time in English. Pines' doctoral dissertation on Islamic atomism; the German version appeared in 1936. Pines presents the atomic theories of matter, time and space, as they are found in the literature of kalam, as well their exposition in the writings of Abŭ Bakr al - Râzî; and then investigates in detail possible sources in the Greek, (...) Indian, and other traditions. The present publication incorporates a few revisions which Pines himself had made in a draft translation. A number of the texts, which Pines consulted in the manuscript, have since been published, and some important studies on the kalam have appeared. Nonetheless, it can be stated in confidence that, sixty years after its first publication, Pines' monograph is till today the most significant work on the subject. (shrink)

Three experiments investigated the nature of visuo-auditory crossmodal cueing in a triadic setting: participants had to detect an auditory signal while observing another agent’s head facing one of the two laterally positioned auditory sources. Experiment 1 showed that when the agent’s eyes were open, sounds originating on the side of the agent’s gaze were detected faster than sounds originating on the side of the agent’s visible ear; when the agent’s eyes were closed this pat-tern of responses was reversed. Two additional (...) experiments showed that the results were sensitive to whether participants could infer a hearing function on the part of the agent. When no ear was depicted on the agent, only a gaze-side advantage was observed , but when the agent’s ear was covered , an ear side advantage was observed only when hearing could still be inferred but not when hearing was inferred to be diminished . The findings are discussed in the context of inferential and simulation processes and joint attention mechanisms. (shrink)

Research has shown that observers automatically align their attention with another’s gaze direction. The present study investigates whether inferring another’s attended location affects the observer’s attention in the same way as observing their gaze direction. In two experiments, we used a laterally oriented virtual human head to prime one of two laterally presented targets. Experiment 1 showed that, in contrast to the agent with closed eyes, observing the agent with open eyes facilitated the observer’s alignment of attention with the primed (...) target location. Experiment 2, where either sunglasses or occluders concealed the agent’s eye direction, showed that only the agent with the sunglasses facilitated the observer’s alignment of attention with the target location. Taken together, the data demonstrate that head orientation alone is not sufficient to trigger a shift in the observer’s attention, that gaze direction is crucial to this process, and that inferring the region to which another person is attending does facilitate the alignment of attention. (shrink)

This article explores textual, paleographic, and archeological evidence for the “Long Wall” of Qi, arguably one of the earliest long walls erected on Chinese soil. It analyzes the possible dates of the Wall’s constructions, its route, its defensive role, and its relation to military, political, economic, and administrative developments of the Warring States period. I argue that the Long Wall played a significant role in Qi’s military strategy in the fifth and fourth centuries BCE, bolstering its defensive capabilities. In the (...) long term, however, the Wall might have inadvertently hindered Qi’s southward expansion, placing it in a disadvantageous position versus its rivals. (shrink)

Volume I : Studies in the Philosophy of Abu'l- Barak t al-Baghd d , deals with various aspects of the philosophy of Abu'l-Barakat al-Baghdadi. Some of Avicenna's physical and psychological doctrines are also discussed.

Among the many strengths of Tao Jiang's magnum opus, Origins of Moral-Political Philosophy in Early China, his analysis of the fa tradition (or the fa school, fajia 法家, often misleadingly dubbed Legalists)1 stands out as a major achievement. This achievement is immediately observable from the depth and seriousness with which the fa tradition is covered. Two out of the book's seven chapters (nine if we count Introduction and Conclusion) deal with fa thinkers: chapter 4 is dedicated to Shen Buhai 申不害 (...) (d. 337 b.c.e.), Shang Yang 商鞅 (d. 338 b.c.e.), and Shen Dao 慎到 (fourth century b.c.e.?); chapter 7 deals with Han Fei 韓非 (d. 233 b.c.e.). These chapters account for 112 pages out of the book's 476 (excluding... Read More. (shrink)

In this study, we apply MOSAIC (model of syntax acquisition in children) to the simulation of the developmental patterning of children's optional infinitive (OI) errors in 4 languages: English, Dutch, German, and Spanish. MOSAIC, which has already simulated this phenomenon in Dutch and English, now implements a learning mechanism that better reflects the theoretical assumptions underlying it, as well as a chunking mechanism that results in frequent phrases being treated as 1 unit. Using 1, identical model that learns from child‐directed (...) speech, we obtain a close quantitative fit to the data from all 4 languages despite there being considerable cross‐linguistic and developmental variation in the OI phenomenon. MOSAIC successfully simulates the difference between Spanish (a pro‐drop language in which OI errors are virtually absent) and obligatory subject languages that do display the OI phenomenon. It also highlights differences in the OI phenomenon across German and Dutch, 2 closely related languages whose grammar is virtually identical with respect to the relation between finiteness and verb placement. Taken together, these results suggest that (a) cross‐linguistic differences in the rates at which children produce OIs are graded, quantitative differences that closely reflect the statistical properties of the input they are exposed to and (b) theories of syntax acquisition need to consider more closely the role of input characteristics as determinants of quantitative differences in the cross‐linguistic patterning of phenomena in language acquisition. (shrink)

This superb abridgement and annotated translation of Maimonides' monumental work includes discussions of divine language, the scope and limits of human knowledge, cosmological doctrines concerning the creation or eternity of the world, prophecy and providence, the nature and purpose of divine law, and moral and political philosophy.