The neurobiology and development of human morality in light of evolution -- More than genes : human inheritances and the moral sense -- The dynamic self : emotions and development -- Moral heritage 1 : engagement of the heart -- Moral heritage 2 : communal imagination -- Undercare and the stress response : early life gone wrong -- The morality that stress promotes : self protective ethics -- Shifting moral mindsets -- Culture and imagination: cooperation or competition? -- Paths to (...) moral wisdom -- Common-self wisdom: fostering a good life for self and others -- The road to human excellence and flourishing. (shrink)

Organoids and specifically human cerebral organoids (HCOs) are one of the most relevant novelties in the field of biomedical research. Grown either from embryonic or induced pluripotent stem cells, HCOs can be used as in vitro three-dimensional models, mimicking the developmental process and organization of the developing human brain. Based on that, and despite their current limitations, it cannot be assumed that they will never at any stage of development manifest some rudimentary form of consciousness. In the absence of behavioral (...) indicators of consciousness, the theoretical neurobiology of consciousness being applied to unresponsive brain-injured patients can be considered with respect to HCOs. In clinical neurology, it is difficult to discern a capacity for consciousness in unresponsive brain-injured patients who provide no behavioral indicators of consciousness. In such scenarios, a validated neurobiological theory of consciousness, which tells us what the neural mechanisms of consciousness are, could be used to identify a capacity for consciousness. Like the unresponsive patients that provide a diagnostic difficulty for neurologists, HCOs provide no behavioral indicators of consciousness. Therefore, this article discusses how three prominent neurobiological theories of consciousness apply to human cerebral organoids. From the perspective of the Temporal Circuit Hypothesis, the Global Neuronal Workspace Theory, and the Integrated Information Theory, we discuss what neuronal structures and functions might indicate that cerebral organoids have a neurobiological capacity to be conscious. (shrink)

‘Plant neurobiology’ has emerged in recent years as a multidisciplinary endeavor carried out mainly by steady collaboration within the plant sciences. The field proposes a particular approach to the study of plant intelligence by putting forward an integrated view of plant signaling and adaptive behavior. Its objective is to account for the way plants perceive and act in a purposeful manner. But it is not only the plant sciences that constitute plant neurobiology. Resources from philosophy and cognitive science are central (...) to such an interdisciplinary project, if plant neurobiology is to maintain its target well-focused. This manifesto outlines a road map for the establishment and development of a new subject—the Philosophy of Plant Neurobiology—, a new field of research emerging at the intersection of the philosophy of cognitive science and plant neurobiology. The discipline is herewith presented, introducing challenges and novel lines of engagement with the empirical investigation, and providing an explanatory framework and guiding principles that will hopefully ease the integration of research on the quest for plant intelligence. (shrink)

Are there neurobiological reasons why we are willing to trust other people and why ‘trust’ and moral values such as ‘care’ play a quite pivotal role in our social lives and the judgements we make, including our social interactions and judgements made in the context of schooling? In pursuing this question, this paper largely agrees with claims made by Patricia Churchland in her 2011 book Braintrust. She believes that moral values are rooted in basic brain circuitry and chemistry, which have (...) been shaped over evolutionary time. However, these naturalistic claims raise important issues, including the standard philosophical objection that they fall victim to the naturalistic and/or deontic fallacies. This paper provides an overview of the neurobiology of trust and examines some of the main objections, in the belief that recognising the neurobiological substrate of care and trust can deepen our appreciation of the role these play in education. (shrink)

Paul Churchland has recently argued that empirical evidence strongly suggests that perception is penetrable to the beliefs or theories held by individual perceivers (1988). While there has been much discussion of the sorts of psychological cases he presents, little has been said about his arguments from neurology. I offer a critical examination of his claim that certain efferents in the brain are evidence against perceptual encapsulation. I argue that his neurological evidence is inadequate to his philosophical goals, both by itself (...) and taken in concert with his psychological evidence. (shrink)

Efforts to bridge emotion theory with neurobiology can be facilitated by dynamic systems (DS) modeling. DS principles stipulate higher-order wholes emerging from lower-order constituents through bidirectional causal processes cognition relations. I then present a psychological model based on this reconceptualization, identifying trigger, self-amplification, and self-stabilization phases of emotion-appraisal states, leading to consolidating traits. The article goes on to describe neural structures and functions involved in appraisal and emotion, as well as DS mechanisms of integration by which they interact. These mechanisms (...) include nested feedback interactions, global effects of neuromodulation, vertical integration, action-monitoring, and synaptic plasticity, and they are modeled in terms of both functional integration and temporal synchronization. I end by elaborating the psychological model of emotion–appraisal states with reference to neural processes. (shrink)

Patricia Smith Churchland's Neurophilosophy argues that a mind is the same thing as the complex patterns of neural activity in a human brain and, furthermore, that we will be able to find out interesting things about the mind by studying the brain. I basically agree with this stance and my comments are divided into four sections. First, comparisons between human and non?human primate brains are discussed in the context, roughly, of where one should locate higher functions. Second, I examine Churchland's (...) views on reduction and levels of organization, which I find mostly congenial. Third, a key point of disagreement about the relationship and importance of language to specifically human cognition is taken up. I like Churchland's critique of certain sentential paradigms, but I try to show using an analogy with cellular coding systems why we need to get a better theory of ?sentences?. Finally, I discuss how the models introduced in the last chapter might be extended to make better contact with neurobiology and language. (shrink)

Neurobiological models of language need a level of analysis that can account for the typical range of language phenomena. Because linguistically motivated models have been successful in explaining numerous language properties, it is premature to dismiss them as biologically irrelevant. Models attempting to unify neurobiology and linguistics need to be sensitive to both sources of evidence.

Interpersonal neurobiology (IPNB) is a burgeoning interdisciplinary field that focuses on ways in which relationships shape and transform the architecture and functioning of the human brain. IPNB points to four specific conditions that appear to encourage the emergence of empathy. Further, these conditions, when gathered together, may constitute the core components of a spirituality of compassion. Following definitions and a discussion of interdisciplinary method, this essay delineates IPNB's main tenets and demonstrates ways in which IPNB sheds light on important aspects (...) of human empathy and compassion. Drawing on this analysis, it introduces the four conditions that encourage the emergence of empathy in individuals and groups and shows why they may be central elements of a spirituality of compassion. A case study, in which the Native American Ojibwe practice of the talking circle is described and assessed through the lens of the IPNB-derived spirituality of compassion, demonstrates the evaluative usefulness of this set of conditions. (shrink)

Extraversion has two central characteristics: (1) interpersonalengagement, which consists of affiliation (enjoying and valuing close interpersonal bonds, being warm and affectionate) and agency (being socially dominant, enjoying leadership roles, being assertive, being exhibitionistic, and having a sense of potency in accomplishing goals) and (2) impulsivity, which emerges from the interaction of extraversion and a second, independent trait (constraint). Agency is a more general motivational disposition that includes dominance, ambition, mastery, efficacy, and achievement. Positive affect (a combination of positive feelings and (...) motivation) is closely associated with extraversion. Extraversion is accordingly based on positiveincentivemotivation. (shrink)

This paper outlines the functional capacities of a novel scheme for cognitive representation and computation, and it explores the possible implementation of this scheme in the massively parallel organization of the empirical brain. The suggestion is that the brain represents reality by means of positions in suitably constitutes phase spaces; and the brain performs computations on these representations by means of coordinate transformations from one phase space to another. This scheme may be implemented in the brain in two distinct forms: (...) (1) as a phase-space sandwich, which may explain certain laminar structures, such as cerebral cortex and the superior colliculus; and (2) as a neural matrix, which may explain other structures, such as the beautifully orthogonal architecture of the cerebellum. (shrink)

While life in general can be explained by the mechanisms of physics, chemistry and biology, to many scientists and philosophers it appears that when it comes to explaining consciousness, there is what the philosopher Joseph Levine called an “explanatory gap” between the physical brain and subjective experiences. Here we deduce the living and neural features behind primary consciousness within a naturalistic biological framework, identify which animal taxa have these features (the vertebrates, arthropods, and cephalopod molluscs), then reconstruct when consciousness first (...) evolved and consider its adaptive value. We theorize that consciousness is based on all the complex system features of life, plus the even more complex features of elaborate brains. We argue that the main reason why the explanatory gap between the brain and experience has been so refractory to scientific explanation is that it arises from both life and from varied and diverse brains and brain regions, so bridging the gap requires a complex, multifactorial account that includes the great diversity of consciousness, its personal nature that stems from embodied life, and the special neural features that make consciousness unique in nature. (shrink)

Gold & Stoljar pose a dilemma for linguistics should neurobiology win out as the science of mind. The dilemma can be avoided by reestablishing linguistics as an autonomous discipline, rather than a branch of the science of mind. Independent considerations for doing this are presented.

With the aid of some Scotistic conceptual distinctions, I develop a way of meeting the apparent deterministic sway of neurobiology. I make a careful distinction between formal and material freedom. Formal freedom, the ability to will or not to will a certain state of affairs regardless of whether it can be effectuated, remains, even if our material freedom to effectuate it is hampered by neurobiological mechanisms. These conceptual findings are linked with contemporary empirical research on obsessive-compulsive disorder and the possibility (...) of volitional modulation of cerebral function. (shrink)

The concept of truth arises from puzzling over distinctions between the real and the apparent, while the origin of these distinctions lies in the neurobiology of mammalian cerebral lateralization, that is, in the evolution of brains that can address the world both indicatively and subjunctively; brains that represent the world both categorically and hypothetically. After some 2,500 years of thinking about it, the Western philosophical tradition has come up with three major theories of truth: correspondence, coherence, and pragmatist. Traditional philosophy (...) has nevertheless failed to arbitrate much among these views; certainly no clear winner has emerged. I argue, however, that contemporary neuroscience provides adequate theoretical grounds for a unified theory of truth. More specifically, I contend that the correspondence, the coherence, and the pragmatic utility of symbols are each biological features of our neurophysiological information processing systems—that is to say, our brains. On my view, the traditional trifurcation of philosophical accounts of the predicate, “is true”, stems from a trifurcation of focus on the information latent in sensory, motor, and somatosensory cortices of the human brain. (shrink)

Evolutionary psychologists claim that the mind contains “hundreds or thousands” of “genetically specified” modules, which are evolutionary adaptations for their cognitive functions. We argue that, while the adult human mind/brain typically contains a degree of modularization, its “modules” are neither genetically specified nor evolutionary adaptations. Rather, they result from the brain’s developmental plasticity, which allows environmental task demands a large role in shaping the brain’s information-processing structures. The brain’s developmental plasticity is our fundamental psychological adaptation, and the “modules” that result (...) from it are adaptive responses to local conditions, not past evolutionary environments. If different individuals share common environ- ments, however, they may develop similar “modules,” and this process can mimic the development of genetically specified modules in the evolutionary psychologist’s sense. (shrink)

Neurobiology studies mechanisms of cell signalling. A key question is how cells recognise specific signals. In this context, olfaction has become an important experimental system over the past 25 years. The olfactory system responds to an array of structurally diverse stimuli. The discovery of the olfactory receptors (ORs), recognising these stimuli, established the olfactory pathway as part of a greater group of signalling mechanisms mediated by G-protein-coupled receptors (GPCRs). GPCRs are the largest protein family in the mammalian genome and involved (...) in numerous fundamental physiological processes. The OR family exhibits two characteristics that make them an excellent model system to understand GPCRs: its size and the structural diversity of its members. Research on the OR binding site investigates what amino acid sequences determine the receptor-binding capacity. This promises a better understanding of how the basic genetic makeup of GPCRs relates to their diversification in ligand-binding capacities. (shrink)

_Spiritual practices have been proposed to have many beneficial effects as far as mental health is concerned. The exact neural basis of these effects is slowly coming to light and different imaging techniques have elucidated the neural basis of meditative practices. The evidence though preliminary and based on studies replete with methodological constraints, points toward the involvement of the prefrontal and parietal cortices. The available data on meditation focus on activated frontal attentional network. Neuroimaging studies have shown that meditation results (...) in an activation of the prefrontal cortex, activation of the thalamus and the inhibitory thalamic reticular nucleus and a resultant functional deafferentation of the parietal lobe. The neurochemical change as a result of meditative practices involves all the major neurotransmitter systems. The neurotransmitter changes contribute to the amelioration of anxiety and depressive symptomatology and in part explain the psychotogenic property of meditation. This overview highlights the involvement of multiple neural structures, the neurophysiological and neurochemical alterations observed in meditative practices._. (shrink)

Accounts of causal explanation are standard in philosophy of science. Less common are accounts of experimentation to investigate causal relations: detailed discussions of the specific kinds of experiments scientists design and run. Silva, Landreth, and Bickle’s account of “connection experiments” derives directly from landmark experiments in “molecular and cellular cognition.” We start with its key components, and then using a detailed case study from recent social neuroscience we emphasize and extend three features of SLB’s account: a division of distinct types (...) of connection experiments, each providing a different type of evidence for a hypothesized causal relationship; the typically downward-looking nature of the experimental search for mediating causes in mainstream neurobiology; and most importantly, the centrality of multiple-experiment research programs, with each experiment designed such that if successful its results can be integrated with the others, toward the goal of confirming multiple-phenomena causal pathways. Our extension of SLB’s account complements existing philosophical work on experimentation in neurobiology. (shrink)

There continues to be a debate on whether addiction is best understood as a brain disease or a moral condition. This debate, which may influence both the stigma attached to addiction and access to treatment, is often motivated by the question of whether and to what extent we can justly hold addicted individuals responsible for their actions. In fact, there is substantial evidence for a disease model, but the disease model per se does not resolve the question of voluntary control. (...) Recent research at the intersection of neuroscience and psychology suggests that addicted individuals have substantial impairments in cognitive control of behavior, but this "loss of control" is not complete or simple. Possible mechanisms and implications are briefly reviewed. (shrink)

This paper employs an interventionist framework to elucidate some issues having to do with explanation in neurobiology and with the differences between mechanistic and non-mechanistic explanations.

Analytic and continental philosophies of mind are too long divided. In both traditions there is extensive discussion of consciousness, the mind-body problem, intentionality, subjectivity, perception (especially visual) and so on. Between these two discussions there are substantive disagreements, overlapping points of insight, meaningful differences in emphasis, and points of comparison which seems to offer nothing but confusion. In other words, there are the ideal circumstances for doing philosophy. Yet, there has been little discourse. This paper invites expanding discourse between these (...) two philosophical traditions. The first part briefly describes the existing literature which works across the analytic- phenomenology divide, situating my work within it as a focus on analytic physicalism and phenomenal explanation. In the longer second part, I sketch a model for explanation embedded simultaneously in both traditions. Hopefully, a theoretical framework emerges that the unlikely combination of Maurice Merleau- Ponty and Patricia Churchland could accept. In the third part, I apply the three-tiered model to a discussion of plasticity and suggest that the model both reflects existing research across three levels of analysis and can be a fruitful way to approach future research. My suggestion for a three-tiered model is quite tentative. Much less tentative is my claim that constructive dialogue between phenomeno- logical and physicalist study of consciousness is long-overdue, illuminating, and practical. (shrink)

This chapter contains sections titled: Aesthetics Musical Syntax, Discrepancy and Activation Probability, Expectations, and Learning Dopamine, Discrepancy and the Prediction of Reward Musement and the Play of Ideas Conclusion.

This article focuses on the substantial progress in understanding the psychology and neurobiology of sensory pleasure that has been made over the last decade. The link between pleasure and happiness has a long history in psychology. The growing evidence for the importance of affect in psychology and neuroscience shows a scientific account that involves hedonic pleasures and displeasures. A neurobiological understanding is required of how positive and negative effects are balanced in the brain. The article surveys developments in understanding brain (...) mechanisms of pleasure. It identifies a number of brain regions that are important in the brain's hedonic networks, and speculated on potential interaction with eudaimonic networks. The scientific study of pleasure and affect demonstrates the evolution of emotions and affective expressions, and suggests that these are adaptive responses to environmental situations. (shrink)

With the discovery of the possibility of neurobiologically and genetically interpreting the actions of a moral agent, the issue of the status of morality returned to applied ethics with renewed vigor. The biotechnological understanding of society as a whole has been a long-running trend in technoscience and can be considered as a transgression of (bio-) technologies into the sphere of ethics. The essence of the conflict between bio-conservative ethics and techno-oriented utilitarians lies in the plane of violation of the fundamental (...) value of autonomy (J. Harris) and the destruction of the principle of solidarity and equality (A. Buchanan). Supporters of techno-determined moral action as conditions for the expansion of technology into the field of morality put forward the predictability of consequences as a condition for the legitimation of technology (N. Agar), the need to prevent maximum harm (J. Savulescu, I. Persson) and the right to an autonomous choice of a biotechnological regulation of morality (V. Rakic). At the center of the discussion is the problem of the good, for the practical solution of which moral outsourcing mechanisms have already been envisaged (e.g. the service of triage officers in disaster medicine, extended informed consent for biobanks). The article compares moral action as a choice, moral action as a coercion and moral action as outsourcing, and determines the place of the neurobiological interpretation of good and moral action within the theoretical understanding of a moral act in applied ethics. In particular, the role of a cognitive act in the context of a moral act is examined, the problem of deferred risks and their regulation when making a moral decision is analyzed. It is concluded that one of the manifestations of the impact of (bio) technology on a person is the complicacy and transformation of moral decision-making models, in connection with which the universal methods that formulate a moral action (moral act as a choice) can be supplemented by new models that constitute good and moral action. (shrink)

With a focus on receptive language, we examine the neurobiological evidence for the interdependence of receptive and expressive language processes. While we agree that there is compelling evidence for such interdependence, we suggest that Pickering & Garrod's (P&G's) account would be enhanced by considering more-specific situations in which their model does, and does not, apply.