Despite the recent discovery that thalidomide causes limb defects by targeting highly angiogenic, immature blood vessels, several challenges still remain and new ones have arisen. These include understanding the drug's species specificity, determining molecular target(s) in the endothelial cell, shedding light on the molecular basis of phocomelia and producing a form of the drug that is clinically effective without having side effects. Now that the trigger of thalidomide‐induced teratogenesis has been uncovered, a framework is proposed, incorporating and uniting previous models (...) of thalidomide action, explaining how thalidomide causes not just limb defects, but also all the other defects it induces. (shrink)

I defend ethical hedonism, the view that pleasure is the sole good thing, by arguing that it offers the only answer to an argument for moral skepticism. The skeptical problem arises from widespread fundamental moral disagreement, which entails the presence of enough moral error to undermine the reliability of most processes generating moral belief. We know that pleasure is good through the reliable process of phenomenal introspection, which reveals what our experiences are like. If knowing of pleasure’s goodness through phenomenal (...) introspection is the only reliable way to form our initial moral beliefs, we should accept ethical hedonism. (shrink)

What is morality? In Practical Expressivism, I argue that morality is a purely natural interpersonal co-ordination device, whereby human beings express their attitudes in order to influence the attitudes and actions of others. -/- The ultimate goal of these expressions is to find acceptable ways of living together. This 'expressivist' model for understanding morality faces well-known challenges concerning 'saving the appearances' of morality, because morality presents itself to us as a practice of objective discovery, not pure expression. -/- This book (...) demonstrates how a properly developed expressivist view can overcome this objection, by showing that even if moral practice is fundamentally expressive, it can still come to possess those features that make it appear objective (features such as talk and thought of moral disagreement, truth and belief, and the applicability of logical notions to moral sentences). The key to this development is to emphasise the unique and intricate practical role that morality plays in our lives. Practical expressivism is also practical in the further sense that it provides repeatable patterns that expressivists can deploy in coming to understand the apparently objective features of morality. (shrink)

We are constantly called upon to evaluate the evidential weight of testimony, and to balance its deliverances against our own independent thinking. ‘Intellectual autonomy’ is the virtue that is supposed to be displayed by those who engage in cognition in this domain well. I argue that this is at best a misleading label for the virtue, because virtuous cognition in this domain consists in thinking with others, and intelligently responding to testimony. I argue that the existing label supports an excessively (...) individualistic conception of good thinking, both within and outside philosophy. I propose replacing ‘intellectual autonomy’ with ‘intellectual interdependence’, which properly emphasises the depth of our reliance on one another, without suggesting we ought ever to be epistemically servile. (shrink)

The widespread conviction that we are living in a post-truth era rests on two claims: that a large number of people believe things that are clearly false, and that their believing these things reflects a lack of respect for truth. In reality, however, fewer people believe clearly false things than surveys or social media suggest. In particular, relatively few people believe things that are widely held to be bizarre. Moreover, accepting false beliefs does not reflect a lack of respect for (...) truth. Almost everyone’s beliefs are explained by rationally warranted trust in some sources rather than others. This allows us to explain why people have false beliefs. (shrink)

Neil Tennant presents an original logical system with unusual philosophical, proof-theoretic, metalogical, computational, and revision-theoretic virtues. Core Logic is the first system that ensures both relevance and adequacy for the formalization of all mathematical and scientific reasoning.

Discussions of virtue signaling to date have focused exclusively on the signaling of the moral virtues. This article focuses on intellectual virtue signaling: the status-seeking advertising of supposed intellectual virtues. Intellectual virtue signaling takes distinctive forms. It is also far more likely to be harmful than moral virtue signaling, because it distracts attention from genuine expertise and gives contrarian opinions an undue prominence in public debate. The article provides a heuristic by which to identify possible instances of intellectual virtue signaling. (...) When people with no relevant expertise rapidly move to offer their opinions on a wide range of topics as soon as these topics become fashionable or newsworthy, and especially when these opinions are contrarian, we should suspect them of intellectual virtue signaling. (shrink)

This paper replies to the contributors to a symposium on the book Bad Beliefs. It groups the criticisms and concerns of the contributors under the headings “Gaps and Holes”, “Rationality”, “Epistemic Virtue”, “Agency and Control” and “Nudges”. It defends the view that bad belief formation and maintenance is very importantly rational, though it also acknowledges gaps, limitations and unanswered questions.

McKenna’s critique (rather than criticisms) of idealized approaches to epistemology is an important contribution to the literature. In this brief discussion, I set out his main concerns about more idealized approaches, within and beyond social epistemology, before turning to some issues I think he neglects. I suggest that it’s important to pay attention to the prestige hierarchy in philosophy, and to how that hierarchy can serve ideological purposes. The greater prestige of more abstract approaches plays a role in determining what (...) issues and what voices we attend to. (shrink)

What grounds facts of the form? One promising answer is: facts of the form. A different promising answer is: x itself. Isaac Wilhelm has recently argued that the second answer is superior to the first. In this paper, I rebut his argument.

Most contemporary theories of perception, including leading forms of representationalism and naive realism, are monistic: they assume that to consciously perceive is to deploy only one kind of sensory awareness. Here I instead argue for rich pluralism, which says that to consciously perceive is to deploy two very different kinds of sensory awareness in concert: representational awareness of particulars, and non-representational, partly essence-revealing awareness of sensory qualities.

This paper argues that qualia share their physical correlates' locations. The first premise comes from the theory of relativity: If something shares a time with a physical event in all reference frames, it shares that physical event’s location. The second premise is that qualia share times with their correlates in all reference frames. Having qualia and correlates share locations makes relations between them easier to explain, improving both physicalist and dualist theories.

This study examines how the Gödel phenomena are to be treated in core logic. We show in formal detail how one can use core logic in the metalanguage to prove Gödel’s incompleteness theorems for arithmetic even when classical logic is used for logical closure in the object language.

The author comments on the article “The Neurobiology of Addiction: Implications for Voluntary Control of Behavior,‘ by S. E. Hyman. Hyman’s article suggests that addicted individuals have impairments in cognitive control of behavior. The author agrees with Hyman’s view that addiction weakens the addict’s ability to align his actions with his judgments. The author states that neuroethics may focus on brains and highlight key aspects of behavior but we still risk missing explanatory elements. Accession Number: 24077912; Authors: Levy, Neil (...) 1,2; Email Address: [email protected]; Affiliations: 1: University of Melbourne, Parkville 3010, Australia; 2: University of Oxford; Subject: ADDICTIONS; Subject: ALCOHOLISM; Subject: COGNITION; Subject: BEHAVIOR; Subject: JUDGMENT; Subject: HYMAN, S. E.; Subject: NEUROBIOLOGY; Number of Pages: 2p. (shrink)

In 2015, in preparation for implementation of the California End of Life Option Act, the UCLA Workgroup dedicated scores of hours to exploring the ethical underpinnings of aid-in-dying and the guid...

This book focuses on the nature and importance of harm by providing a sustained defense of the counterfactual comparative account, in particular by extending the account to allow for a certain kind of plural or collective harm. According to the counterfactual comparative account, an event harms a person provided that she would have been better off had it not occurred. On the account defended in this book, there are cases in which some events harm a given individual even though none (...) of them by itself harms the individual. This account aims to solve the most serious problem facing the counterfactual comparative account, a problem involving cases of preemption. In such cases, an intuitively harmful event does not make the victim worse off, since if it had not occurred, another event would have had a similar adverse influence on the victim’s well-being. The book also contains discussion of various competing accounts of harm, and it replies to other challenges to the counterfactual comparative account. It argues, moreover, that an action that would harm a person does not thereby have a strong moral reason against it; if there is a strong moral reason against a harmful act, the reason is due primarily to some of the act’s other features. (shrink)

In Thus Spoke Zarathustra, Nietzsche presents passion as constituting human agency. He encountered this Humean view in Schopenhauer, and recognized its explanatory advantages over Platonic and Kantian rationalism. Zarathustra's poetic speeches anticipate and address contemporary objections to the view that passion constitutes agency. "On the Despisers of the Body" explains why understanding the self as constituted by passion provides better explanations of reasoning, value judgment, and the unity of the self than Christine Korsgaard's neo-Kantian view. "On Enjoying and Suffering the (...) Passions" explains why understanding virtues as constituted by passions provides a better explanation of moral phenomenology than John McDowell's rationalism. (shrink)

In this paper, I advance a new hypothesis about what the ordinary concept of perceptual experience might be. To a first approximation, my hypothesis is that it is the concept of something that seems to present mind-independent objects. Along the way, I reveal two important errors in Michael Martin’s argument for the very different view that the ordinary concept of perceptual experience is the concept of something that is impersonally introspectively indiscriminable from a veridical perception. This conceptual work is significant (...) because it provides three pieces of good news for the common kind theorist. (shrink)

The independence phenomenon in set theory, while pervasive, can be partially addressed through the use of large cardinal axioms. A commonly assumed idea is that large cardinal axioms are species of maximality principles. In this paper I question this claim. I show that there is a kind of maximality (namely absoluteness) on which large cardinal axioms come out as restrictive relative to a formal notion of restrictiveness. Within this framework, I argue that large cardinal axioms can still play many of (...) their usual foundational roles. (shrink)

Abstractabstract:In his Pragmatism lectures, William James argued that philosophers' temperaments partially determine the theories that they find satisfying, and that their influence explains persistent disagreement within the history of philosophy. Crucially, James was not only making a descriptive claim, but also a normative one: temperaments, he thought, could play a legitimate epistemic role in our philosophical inquiries. This paper aims to evaluate and defend this normative claim.There are three problems for James's view: (1) that allowing temperaments to play a role (...) within inquiry replaces philosophical disagreement with psychological difference; (2) that including temperaments would allow arbitrary elements to influence the outcome of inquiry; and (3) that such a view assumes an implausible metaphysical picture. Through clarifying the nature of temperaments, and what counts as a satisfactory philosophical theory on a pragmatist account, this paper presents an interpretation of James's metaphilosophical claims that can provide satisfactory responses to these problems. (shrink)

Neil Gascoigne provides the first comprehensive introduction Richard Rorty's work. He demonstrates to the general reader and to the student of philosophy alike how the radical views on truth, objectivity and rationality expressed in Rorty's widely-read essays on contemporary culture and politics derive from his earliest work in the philosophy of mind and language. He avoids the partisanship that characterizes much discussion of Rorty's work whilst providing a critical account of some of the dominant concerns of contemporary thought. Beginning (...) with Rorty's early work on concept-change in the philosophy of mind, the book traces his increasing hostility to the idea that philosophy is cognitively privileged with respect to other disciplines. After the publication of Philosophy and the Mirror of Nature, this led to a new emphasis on preserving the moral and political inheritance of the enlightenment by detaching it from the traditional search for rational foundations. This emerging project led Rorty to champion 'ironic' thinkers like Foucault and Derrida, and to his attempt to update the liberalism of J. S. Mill by offering a non-universalistic account of the individual's need to balance their own private interests against their commitments to others. By returning him to his philosophical roots, Gascoigne shows why Rorty's pragmatism is of continuing relevance to anyone interested in ongoing debates about the nature and limits of philosophy, and the implications these debates have for our understanding of what role the intellectual might play in contemporary life. This book serves as both an excellent introduction to Rorty's work and an innovative critique which contributes to ongoing debates in the field. (shrink)

The novice/expert problem is the problem of knowing which apparent expert to trust. Following Alvin Goldman’s lead, a number of philosophers have developed criteria that novices can use to distinguish more from less trustworthy experts. While the criteria the philosophers have identified are indeed useful in guiding expert choice, I argue, they can’t do the work that Goldman and his successors want from them: avoid a kind of testimonial scepticism. We can’t deploy them in the way needed to avoid such (...) scepticism, because it would take genuine expertise to do so. I argue that attempts to deploy them in this sort of deep way involve a kind of transgression akin to, and at least as unreliable as, epistemic trespassing. We should give up trying to solve the novice/expert problem and instead promote better epistemic trust. (shrink)

This article articulates and assesses an imperatival approach to the foundations of mathematics. The core idea for the program is that mathematical domains of interest can fruitfully be viewed as the outputs of construction procedures. We apply this idea to provide a novel formalisation of arithmetic and set theory in terms of such procedures, and discuss the significance of this perspective for the philosophy of mathematics.

As pervasive as the use of the Internet has become in the United States, a huge percentage of the world’s population has yet to ever use a telephone. It seems ironic, then, that there is a concerted effort on the part of industrialized nations to first hook up their traditionally disadvantaged citizens to the Internet and second, to hook up citizens of developing nations. This paper addresses the universal access phenomenon by considering the growth of the Internet in terms of (...) Leaver and Taker users—idioms usually associated with a culture’s interactions with its environment. Leaver cultures interact with their environment in a sustainable manner while Taker cultures produce more than they need and impose their ways upon others. The Internet is explored as a community of users, which in its current state is dominated by Takers. However, realizing the need for a more heterogeneous Internet community, this paper explores incentives for Leaver cultures to assimilate online and methods of improving interface designs to be more intuitive to Leaver communities. It is hoped that a tragedy of the commons of Internet resources can be avoided as more Leavers participate in the sustainment of the Internet as a valuable tool for all communities. (shrink)

The philosopher Jerry Fodor was a key figure alongside Noam Chomsky in the revolution that led to the renaissance of the cognitive sciences from around 1960. This chapter describes key difference between Chomsky and Fodor. It focuses on Chomsky's and Fodor's conceptions of modularity. The chapter discusses two ways of understanding Chomsky's proposal, in particular how it claims an underlying faculty is related to processing and performance. Chomsky is largely agnostic on this question; the commitments of his programme are to (...) be found elsewhere. The most persuasive evidence for Fodorian modules, as for Chomskyan faculties, comes from dissociations. The chapter also reviews the evidential foundation of all versions of modularity: double dissociation (impairments of one or more mental abilities caused by accidents or other pathology which leave other abilities intact). (shrink)

According to the Epistemic Theory of Mind, knowledge is part of the best overall framework for explaining behavior at the psychological level. This theory, which has become increasingly popular in recent decades, has almost always been conjoined with an invariantist theory of “knows.” In this paper, I argue that this is a mistake: the Epistemic Theory of Mind is far more explanatorily powerful when conjoined with contextualism. I conclude that if the Epistemic Theory of Mind is true, then there is (...) a powerful new reason to accept contextualism. (shrink)

I provide an examination and comparison of modal theories for underwriting different non-modal theories of sets. I argue that there is a respect in which the `standard' modal theory for set construction---on which sets are formed via the successive individuation of powersets---raises a significant challenge for some recently proposed `countabilist' modal theories (i.e. ones that imply that every set is countable). I examine how the countabilist can respond to this issue via the use of regularity axioms and raise some questions (...) about this approach. I argue that by comparing them with the `standard' uncountabilist theory, a new approach that brings in arbitrariness rather than the strict controls of forcing is desirable. (shrink)

We are about to see the emergence of religions devoted to the worship of Artificial Intelligence (AI). Such religions pose acute risks, both to their followers and to the public. We should require their creators, and governments, to acknowledge these risks and to manage them as best they can. However, these new religions cannot be stopped altogether, nor should we try to stop them if we could. We must accept that AI worship will become part of our culture, and we (...) must learn to live with it. Indeed, we should do much more than this. We should value it as a new source of meaning in a rapidly-changing world. AI-based religions deserve respect and recognition alongside other, more established ones, and they should be granted the same level of legal protection. (shrink)

Some people argue that the distribution of medical resources should be sensitive to agents’ responsibility for their ill-health. In contrast, others point to the social determinants of health to argue that the collective agents that control the conditions in which agents act should bear responsibility. To a large degree, this is a debate in which those who hold individuals responsible currently have the upper hand: warranted appeals to individual responsibility effectively block allocation of any significant degree of responsibility to collective (...) agents. We suggest that a different understanding of individual responsibility might lead to a fairer allocation of blame. Scaffolded agency is individual agency exercised in a context in which opportunities and affordances are structured by others. Appeals to scaffolded agency at once recognize the role of the individual and of the collective agents who have put the scaffolds in place. (shrink)

This collection of essays, published to coincide with Tony Honore's sixty-fifth birthday, focuses on the areas where Honore's thought has made the most significant contribution: Roman law and jurisprudence. Included are essays by P.S. Atiyah, Zenon Bankowski, John Bell, Peter Birks, John W. Cairs, Hugh Collins, David Daube, W. M. Gordon, J. W. Harris Nicola Lacey, A. D. E. Lewis, Detlef Liebs, G. D. MacCormack, Neil MacCormick, G. Maher, Pieter Norr, Alan Rodger, and Peter Stein.

Clinical ethics consultants are inevitably called to participate in and bear witness to emotionally challenging cases. With the move toward the professionalization of ethics consultants, the responsibility to respond to and address difficult ethical dilemmas is likely to fall to a small set of people or a single clinical ethicist. Combined with time constraints, the urgent nature of these cases, and the moral distress of clinicians and staff encountered during consultation, like other healthcare professionals such as physicians and nurses, clinical (...) ethics consultants could risk burnout. If it is true that clinical ethicists are at risk for burnout, an important strategy to avoid burnout is to develop sound self-care practices. This article reviews the goals and skills of ethics consultation and the role-specific reasons that clinical ethicists may be at risk for burnout, and argues that clinical ethicists may need to engage in self-care practices. Strategies to address burnout are reviewed and opportunities for future research are identified. (shrink)

How does our language relate to reality? This is a question that is especially pertinent in set theory, where we seem to talk of large infinite entities. Based on an analogy with the use of models in the natural sciences, we argue for a threefold correspondence between our language, models, and reality. We argue that so conceived, the existence of models can be underwritten by a weak notion of existence, where weak existence is to be understood as existing in virtue (...) of language. (shrink)

Which is worse: Doing evil or being evil? If we are free to define ourselves through our choices, as existentialism posits, then the latter is worse. This paper attempts to resolve the issue of the difference between religious (group) ethics and the ethics of a person of faith that embraces individuals with an existential understanding. In the existential view, the individual (whether the self or the other) is the primary concern, and so the issue of personal relational morality supersedes religious (...) narratives, social morality and popular ethics (White, 2002). If we think and choose, there is the possibility that we may occasionally make a mistake and do evil. However, if we do not think about our choices, and if the conventions we hold happen to be flawed in some way, then we become defined by a continual cycle of mistakes. Existentialism teaches that we become who we are in the process of making choices; therefore the difference between doing evil and being evil can be found in the small but important flow of thinking, relating and choosing. (shrink)

Following World War II, Viktor Frankl revolutionized the field of psychotherapy with the inception of logotherapy. With Logotherapy: Viktor Frankl, Life and Work, Soggie offers a compelling and comprehensive introduction to both the man and his contribution to psychotherapy. Through the examination of Frankl’s life as a boy to his days in a concentration camp and his post-war work, Soggie paints a rich portrait of Frankl and the origins of logotherapy. Complete with in-depth explanations of logotherapy’s key concepts, including dimensionalism, (...) love, responsibility, and freedom of the will, this book serves as a great complement to Frankl’s own works and a valuable resource to practitioners and therapists in training alike. (shrink)

Neuroethics has two focuses: ethical issues arising from the sciences of the mind, and the ways in which these same sciences can help us to understand normative questions. In this chapter, I pursue a question in the second kind of neuroethics, exploring how the sciences of the mind help us to understand when agents are responsible for their actions. First, I examine the case of the psychopath, and argue that the relevant data suggests that psychopaths do not act with the (...) kind of quality of will that is plausibly taken to underwrite blameworthiness. I then turn to evidence concerning how we attribute quality of will to other agents, and suggest that it predicts a disposition to overattribute a blameworthy quality of will under certain conditions. If these claims are correct, then we are apt to blame some agents, under some conditions, more than they deserve. Attention to the data can therefore enable us to better calibrate our responsibility judgments. (shrink)

This book is based upon a lecture series that took place between September 2013 and May 2014 to inaugurate the new Canadian Museum for Human Rights. It brings together some of the most influential contemporary thinkers on the theory and practice of human rights.