Despite the recent discovery that thalidomide causes limb defects by targeting highly angiogenic, immature blood vessels, several challenges still remain and new ones have arisen. These include understanding the drug's species specificity, determining molecular target(s) in the endothelial cell, shedding light on the molecular basis of phocomelia and producing a form of the drug that is clinically effective without having side effects. Now that the trigger of thalidomide‐induced teratogenesis has been uncovered, a framework is proposed, incorporating and uniting previous models (...) of thalidomide action, explaining how thalidomide causes not just limb defects, but also all the other defects it induces. (shrink)

The Taming of the True poses a broad challenge to realist views of meaning and truth that have been prominent in recent philosophy. Neil Tennant argues compellingly that every truth is knowable, and that an effective logical system can be based on this principle. He lays the foundations for global semantic anti-realism and extends its consequences from the philosophy of mathematics and logic to the theory of meaning, metaphysics, and epistemology.

Informed consent is a central topic in contemporary biomedical ethics. Yet attempts to set defensible and feasible standards for consenting have led to persistent difficulties. In Rethinking Informed Consent in Bioethics Neil Manson and Onora O'Neill set debates about informed consent in medicine and research in a fresh light. They show why informed consent cannot be fully specific or fully explicit, and why more specific consent is not always ethically better. They argue that consent needs distinctive communicative transactions, by (...) which other obligations, prohibitions, and rights can be waived or set aside in controlled and specific ways. Their book offers a coherent, wide-ranging and practical account of the role of consent in biomedicine which will be valuable to readers working in a range of areas in bioethics, medicine and law. (shrink)

We are constantly called upon to evaluate the evidential weight of testimony, and to balance its deliverances against our own independent thinking. ‘Intellectual autonomy’ is the virtue that is supposed to be displayed by those who engage in cognition in this domain well. I argue that this is at best a misleading label for the virtue, because virtuous cognition in this domain consists in thinking with others, and intelligently responding to testimony. I argue that the existing label supports an excessively (...) individualistic conception of good thinking, both within and outside philosophy. I propose replacing ‘intellectual autonomy’ with ‘intellectual interdependence’, which properly emphasises the depth of our reliance on one another, without suggesting we ought ever to be epistemically servile. (shrink)

Neil Tennant presents an original logical system with unusual philosophical, proof-theoretic, metalogical, computational, and revision-theoretic virtues. Core Logic is the first system that ensures both relevance and adequacy for the formalization of all mathematical and scientific reasoning.

The widespread conviction that we are living in a post-truth era rests on two claims: that a large number of people believe things that are clearly false, and that their believing these things reflects a lack of respect for truth. In reality, however, fewer people believe clearly false things than surveys or social media suggest. In particular, relatively few people believe things that are widely held to be bizarre. Moreover, accepting false beliefs does not reflect a lack of respect for (...) truth. Almost everyone’s beliefs are explained by rationally warranted trust in some sources rather than others. This allows us to explain why people have false beliefs. (shrink)

Discussions of virtue signaling to date have focused exclusively on the signaling of the moral virtues. This article focuses on intellectual virtue signaling: the status-seeking advertising of supposed intellectual virtues. Intellectual virtue signaling takes distinctive forms. It is also far more likely to be harmful than moral virtue signaling, because it distracts attention from genuine expertise and gives contrarian opinions an undue prominence in public debate. The article provides a heuristic by which to identify possible instances of intellectual virtue signaling. (...) When people with no relevant expertise rapidly move to offer their opinions on a wide range of topics as soon as these topics become fashionable or newsworthy, and especially when these opinions are contrarian, we should suspect them of intellectual virtue signaling. (shrink)

This paper replies to the contributors to a symposium on the book Bad Beliefs. It groups the criticisms and concerns of the contributors under the headings “Gaps and Holes”, “Rationality”, “Epistemic Virtue”, “Agency and Control” and “Nudges”. It defends the view that bad belief formation and maintenance is very importantly rational, though it also acknowledges gaps, limitations and unanswered questions.

In part one, I identify the core logical structure of the precautionary principle and distinguish it from the various key concepts that appear in the many different formulations of the principle. I survey these concepts and suggest a program of further conceptual analysis. In part two, I examine a particular version of the precautionary principle dubbed “the catastrophe principle” and criticize it in light of its similarities to the principle at work in Pascal’s Wager. I conclude with some suggestions for (...) advocates of the precautionary principle who wish their formulation to avoid the pitfalls confronting the catastrophe principle. (shrink)

On his death in 2007, Richard Rorty was heralded by the New York Times as “one of the world’s most influential contemporary thinkers.” Controversial on the left and the right for his critiques of objectivity and political radicalism, Rorty experienced a renown denied to all but a handful of living philosophers. In this masterly biography, Neil Gross explores the path of Rorty’s thought over the decades in order to trace the intellectual and professional journey that led him to that (...) prominence. The child of a pair of leftist writers who worried that their precocious son “wasn’t rebellious enough,” Rorty enrolled at the University of Chicago at the age of fifteen. There he came under the tutelage of polymath Richard McKeon, whose catholic approach to philosophical systems would profoundly influence Rorty’s own thought. Doctoral work at Yale led to Rorty’s landing a job at Princeton, where his colleagues were primarily analytic philosophers. With a series of publications in the 1960s, Rorty quickly established himself as a strong thinker in that tradition—but by the late 1970s Rorty had eschewed the idea of objective truth altogether, urging philosophers to take a “relaxed attitude” toward the question of logical rigor. Drawing on the pragmatism of John Dewey, he argued that philosophers should instead open themselves up to multiple methods of thought and sources of knowledge—an approach that would culminate in the publication of Philosophy and the Mirror of Nature , one of the most seminal and controversial philosophical works of our time. In clear and compelling fashion, Gross sets that surprising shift in Rorty’s thought in the context of his life and social experiences, revealing the many disparate influences that contribute to the making of knowledge. As much a book about the growth of ideas as it is a biography of a philosopher, Richard Rorty will provide readers with a fresh understanding of both the man and the course of twentieth-century thought. (shrink)

What grounds facts of the form? One promising answer is: facts of the form. A different promising answer is: x itself. Isaac Wilhelm has recently argued that the second answer is superior to the first. In this paper, I rebut his argument.

This paper argues that qualia share their physical correlates' locations. The first premise comes from the theory of relativity: If something shares a time with a physical event in all reference frames, it shares that physical event’s location. The second premise is that qualia share times with their correlates in all reference frames. Having qualia and correlates share locations makes relations between them easier to explain, improving both physicalist and dualist theories.

This study examines how the Gödel phenomena are to be treated in core logic. We show in formal detail how one can use core logic in the metalanguage to prove Gödel’s incompleteness theorems for arithmetic even when classical logic is used for logical closure in the object language.

It is widely held that some kinds of deception into sex (e.g., lying about what pets one likes) do not undermine the moral force of consent while other kinds of deception do (e.g., impersonating the consenter’s partner). Tom Dougherty argues against this: whenever someone is deceived into sex by the concealment of a “deal breaker” fact, the normative situation is the same as there being no consent at all. Here it is argued that this conclusion is unwarranted. Dougherty’s negative arguments (...) against alternative theories of the deceptive undermining of consent are flawed, and his two positive arguments are unjustified. (shrink)

In 2015, in preparation for implementation of the California End of Life Option Act, the UCLA Workgroup dedicated scores of hours to exploring the ethical underpinnings of aid-in-dying and the guid...

I am to grateful to Geoff Keeling for his perceptive response1 to my paper.2 In this brief reply, I will argue that he does not succeed in his goal of showing that nudges to reason do not respect autonomy. At most, he establishes only that such nudges may threaten autonomy when used in certain ways and in certain circumstances. As I will show, this is not a conclusion that should give us grounds for particular concerns about nudges. Before turning to (...) this issue, let me correct some small issues of interpretation of my paper. Keeling takes me to be committed to three descriptive claims: that we have entered a post-truth era, that our problem with the rational assessment of evidence is explained by or stems from the backfire effect and that nudges to reason work by exploiting affective mechanisms. I am not committed to accepting any of these claims. …. (shrink)

This book focuses on the nature and importance of harm by providing a sustained defense of the counterfactual comparative account, in particular by extending the account to allow for a certain kind of plural or collective harm. According to the counterfactual comparative account, an event harms a person provided that she would have been better off had it not occurred. On the account defended in this book, there are cases in which some events harm a given individual even though none (...) of them by itself harms the individual. This account aims to solve the most serious problem facing the counterfactual comparative account, a problem involving cases of preemption. In such cases, an intuitively harmful event does not make the victim worse off, since if it had not occurred, another event would have had a similar adverse influence on the victim’s well-being. The book also contains discussion of various competing accounts of harm, and it replies to other challenges to the counterfactual comparative account. It argues, moreover, that an action that would harm a person does not thereby have a strong moral reason against it; if there is a strong moral reason against a harmful act, the reason is due primarily to some of the act’s other features. (shrink)

In Thus Spoke Zarathustra, Nietzsche presents passion as constituting human agency. He encountered this Humean view in Schopenhauer, and recognized its explanatory advantages over Platonic and Kantian rationalism. Zarathustra's poetic speeches anticipate and address contemporary objections to the view that passion constitutes agency. "On the Despisers of the Body" explains why understanding the self as constituted by passion provides better explanations of reasoning, value judgment, and the unity of the self than Christine Korsgaard's neo-Kantian view. "On Enjoying and Suffering the (...) Passions" explains why understanding virtues as constituted by passions provides a better explanation of moral phenomenology than John McDowell's rationalism. (shrink)

In this paper, I advance a new hypothesis about what the ordinary concept of perceptual experience might be. To a first approximation, my hypothesis is that it is the concept of something that seems to present mind-independent objects. Along the way, I reveal two important errors in Michael Martin’s argument for the very different view that the ordinary concept of perceptual experience is the concept of something that is impersonally introspectively indiscriminable from a veridical perception. This conceptual work is significant (...) because it provides three pieces of good news for the common kind theorist. (shrink)

The independence phenomenon in set theory, while pervasive, can be partially addressed through the use of large cardinal axioms. A commonly assumed idea is that large cardinal axioms are species of maximality principles. In this paper I question this claim. I show that there is a kind of maximality (namely absoluteness) on which large cardinal axioms come out as restrictive relative to a formal notion of restrictiveness. Within this framework, I argue that large cardinal axioms can still play many of (...) their usual foundational roles. (shrink)

Abstractabstract:In his Pragmatism lectures, William James argued that philosophers' temperaments partially determine the theories that they find satisfying, and that their influence explains persistent disagreement within the history of philosophy. Crucially, James was not only making a descriptive claim, but also a normative one: temperaments, he thought, could play a legitimate epistemic role in our philosophical inquiries. This paper aims to evaluate and defend this normative claim.There are three problems for James's view: (1) that allowing temperaments to play a role (...) within inquiry replaces philosophical disagreement with psychological difference; (2) that including temperaments would allow arbitrary elements to influence the outcome of inquiry; and (3) that such a view assumes an implausible metaphysical picture. Through clarifying the nature of temperaments, and what counts as a satisfactory philosophical theory on a pragmatist account, this paper presents an interpretation of James's metaphilosophical claims that can provide satisfactory responses to these problems. (shrink)

I argue that evolutionary debunking arguments are dialectically ineffective against a range of plausible positions regarding moral truth. I first distinguish debunking arguments which target the truth of moral judgements from those which target their justification. I take the latter to rest on the premise that such judgements can be given evolutionary explanations which do not invoke their truth. The challenge for the debunker is to bridge the gap between this premise and the conclusion that moral judgements are unjustified. After (...) briefly discussing older attempts to bridge this gap, I focus on Joyce’s recent attempt, which rests on the claim that ‘we do not have a believable account of how moral facts could explain the mechanisms and forces which give rise to moral judgements’. I argue that whether or not there is such an account depends on what it is permissible to assume about moral truth in this context. Further, I suggest that it is reasonable to make assumptions about moral truth which allow for the possibility of at least partial moral epistemologies. The residual challenge for the debunker is to show that these assumptions are unreasonable in a way which doesn’t render their debunking argument superfluous. (shrink)

Neil Gascoigne provides the first comprehensive introduction Richard Rorty's work. He demonstrates to the general reader and to the student of philosophy alike how the radical views on truth, objectivity and rationality expressed in Rorty's widely-read essays on contemporary culture and politics derive from his earliest work in the philosophy of mind and language. He avoids the partisanship that characterizes much discussion of Rorty's work whilst providing a critical account of some of the dominant concerns of contemporary thought. Beginning (...) with Rorty's early work on concept-change in the philosophy of mind, the book traces his increasing hostility to the idea that philosophy is cognitively privileged with respect to other disciplines. After the publication of Philosophy and the Mirror of Nature, this led to a new emphasis on preserving the moral and political inheritance of the enlightenment by detaching it from the traditional search for rational foundations. This emerging project led Rorty to champion 'ironic' thinkers like Foucault and Derrida, and to his attempt to update the liberalism of J. S. Mill by offering a non-universalistic account of the individual's need to balance their own private interests against their commitments to others. By returning him to his philosophical roots, Gascoigne shows why Rorty's pragmatism is of continuing relevance to anyone interested in ongoing debates about the nature and limits of philosophy, and the implications these debates have for our understanding of what role the intellectual might play in contemporary life. This book serves as both an excellent introduction to Rorty's work and an innovative critique which contributes to ongoing debates in the field. (shrink)

This article articulates and assesses an imperatival approach to the foundations of mathematics. The core idea for the program is that mathematical domains of interest can fruitfully be viewed as the outputs of construction procedures. We apply this idea to provide a novel formalisation of arithmetic and set theory in terms of such procedures, and discuss the significance of this perspective for the philosophy of mathematics.

As pervasive as the use of the Internet has become in the United States, a huge percentage of the world’s population has yet to ever use a telephone. It seems ironic, then, that there is a concerted effort on the part of industrialized nations to first hook up their traditionally disadvantaged citizens to the Internet and second, to hook up citizens of developing nations. This paper addresses the universal access phenomenon by considering the growth of the Internet in terms of (...) Leaver and Taker users—idioms usually associated with a culture’s interactions with its environment. Leaver cultures interact with their environment in a sustainable manner while Taker cultures produce more than they need and impose their ways upon others. The Internet is explored as a community of users, which in its current state is dominated by Takers. However, realizing the need for a more heterogeneous Internet community, this paper explores incentives for Leaver cultures to assimilate online and methods of improving interface designs to be more intuitive to Leaver communities. It is hoped that a tragedy of the commons of Internet resources can be avoided as more Leavers participate in the sustainment of the Internet as a valuable tool for all communities. (shrink)

Culturally diverse liberal democracies on both sides of the Atlantic are currently faced with serious questions about the education of their future citizens. What is the balance between the need for social cohesion, and at the same time dealing justly with the demands for exemptions and accommodations from cultural and religious minorities? In contemporary Britain, the importance of this question has been recently highlighted by the concern to develop political and educational strategies capable of countering the influence of extremist voices, (...) in both the majority and minority communities. Starting from recent debates in North America about possible accommodations to meet the concerns of non-liberal religious groups, the book goes on to examine several issues centered on education in culturally-diverse societies. Neil Burtonwood argues persuasively that the work of Isaiah Berlin, the British philosopher and historian of ideas, has considerable potential for illuminating questions about a properly liberal response to pluralism, and the education of cultural minority children in a liberal democracy. This is the first book to bring his writing to bear on education. Berlin's liberalism is distinctive in attending to the benefits that individuals gain from their memberships of cultural identity groups and religious communities, while remaining committed to Enlightenment values based on individual freedom. Yet his need to find compromises to balance the claims of individuals and groups makes Berlin's version of liberal pluralism so relevant to many vital questions of education policy and practice that concern philosophers of education today. (shrink)

The philosopher Jerry Fodor was a key figure alongside Noam Chomsky in the revolution that led to the renaissance of the cognitive sciences from around 1960. This chapter describes key difference between Chomsky and Fodor. It focuses on Chomsky's and Fodor's conceptions of modularity. The chapter discusses two ways of understanding Chomsky's proposal, in particular how it claims an underlying faculty is related to processing and performance. Chomsky is largely agnostic on this question; the commitments of his programme are to (...) be found elsewhere. The most persuasive evidence for Fodorian modules, as for Chomskyan faculties, comes from dissociations. The chapter also reviews the evidential foundation of all versions of modularity: double dissociation (impairments of one or more mental abilities caused by accidents or other pathology which leave other abilities intact). (shrink)

According to the Epistemic Theory of Mind, knowledge is part of the best overall framework for explaining behavior at the psychological level. This theory, which has become increasingly popular in recent decades, has almost always been conjoined with an invariantist theory of “knows.” In this paper, I argue that this is a mistake: the Epistemic Theory of Mind is far more explanatorily powerful when conjoined with contextualism. I conclude that if the Epistemic Theory of Mind is true, then there is (...) a powerful new reason to accept contextualism. (shrink)

I provide an examination and comparison of modal theories for underwriting different non-modal theories of sets. I argue that there is a respect in which the `standard' modal theory for set construction---on which sets are formed via the successive individuation of powersets---raises a significant challenge for some recently proposed `countabilist' modal theories (i.e. ones that imply that every set is countable). I examine how the countabilist can respond to this issue via the use of regularity axioms and raise some questions (...) about this approach. I argue that by comparing them with the `standard' uncountabilist theory, a new approach that brings in arbitrariness rather than the strict controls of forcing is desirable. (shrink)

This collection of essays, published to coincide with Tony Honore's sixty-fifth birthday, focuses on the areas where Honore's thought has made the most significant contribution: Roman law and jurisprudence. Included are essays by P.S. Atiyah, Zenon Bankowski, John Bell, Peter Birks, John W. Cairs, Hugh Collins, David Daube, W. M. Gordon, J. W. Harris Nicola Lacey, A. D. E. Lewis, Detlef Liebs, G. D. MacCormack, Neil MacCormick, G. Maher, Pieter Norr, Alan Rodger, and Peter Stein.

We are about to see the emergence of religions devoted to the worship of Artificial Intelligence (AI). Such religions pose acute risks, both to their followers and to the public. We should require their creators, and governments, to acknowledge these risks and to manage them as best they can. However, these new religions cannot be stopped altogether, nor should we try to stop them if we could. We must accept that AI worship will become part of our culture, and we (...) must learn to live with it. Indeed, we should do much more than this. We should value it as a new source of meaning in a rapidly-changing world. AI-based religions deserve respect and recognition alongside other, more established ones, and they should be granted the same level of legal protection. (shrink)

Some people argue that the distribution of medical resources should be sensitive to agents’ responsibility for their ill-health. In contrast, others point to the social determinants of health to argue that the collective agents that control the conditions in which agents act should bear responsibility. To a large degree, this is a debate in which those who hold individuals responsible currently have the upper hand: warranted appeals to individual responsibility effectively block allocation of any significant degree of responsibility to collective (...) agents. We suggest that a different understanding of individual responsibility might lead to a fairer allocation of blame. Scaffolded agency is individual agency exercised in a context in which opportunities and affordances are structured by others. Appeals to scaffolded agency at once recognize the role of the individual and of the collective agents who have put the scaffolds in place. (shrink)

Clinical ethics consultants are inevitably called to participate in and bear witness to emotionally challenging cases. With the move toward the professionalization of ethics consultants, the responsibility to respond to and address difficult ethical dilemmas is likely to fall to a small set of people or a single clinical ethicist. Combined with time constraints, the urgent nature of these cases, and the moral distress of clinicians and staff encountered during consultation, like other healthcare professionals such as physicians and nurses, clinical (...) ethics consultants could risk burnout. If it is true that clinical ethicists are at risk for burnout, an important strategy to avoid burnout is to develop sound self-care practices. This article reviews the goals and skills of ethics consultation and the role-specific reasons that clinical ethicists may be at risk for burnout, and argues that clinical ethicists may need to engage in self-care practices. Strategies to address burnout are reviewed and opportunities for future research are identified. (shrink)

How does our language relate to reality? This is a question that is especially pertinent in set theory, where we seem to talk of large infinite entities. Based on an analogy with the use of models in the natural sciences, we argue for a threefold correspondence between our language, models, and reality. We argue that so conceived, the existence of models can be underwritten by a weak notion of existence, where weak existence is to be understood as existing in virtue (...) of language. (shrink)

Which is worse: Doing evil or being evil? If we are free to define ourselves through our choices, as existentialism posits, then the latter is worse. This paper attempts to resolve the issue of the difference between religious (group) ethics and the ethics of a person of faith that embraces individuals with an existential understanding. In the existential view, the individual (whether the self or the other) is the primary concern, and so the issue of personal relational morality supersedes religious (...) narratives, social morality and popular ethics (White, 2002). If we think and choose, there is the possibility that we may occasionally make a mistake and do evil. However, if we do not think about our choices, and if the conventions we hold happen to be flawed in some way, then we become defined by a continual cycle of mistakes. Existentialism teaches that we become who we are in the process of making choices; therefore the difference between doing evil and being evil can be found in the small but important flow of thinking, relating and choosing. (shrink)

The one-page 1978 informal proof of Goodman and Myhill is regimented in a weak constructive set theory in free logic. The decidability of identities in general (⁠|$a\!=\!b\vee\neg a\!=\!b$|⁠) is derived; then, of sentences in general (⁠|$\psi\vee\neg\psi$|⁠). Martin-Löf’s and Bell’s receptions of the latter result are discussed. Regimentation reveals the form of Choice used in deriving Excluded Middle. It also reveals an abstraction principle that the proof employs. It will be argued that the Goodman–Myhill result does not provide the constructive set (...) theorist with a dispositive reason for not adopting (full) Choice. (shrink)

In this article, I survey some philosophical attitudes to talk concerning `the' universe of sets. I separate out four different strands of the debate, namely: (i) Universism, (ii) Multiversism, (iii) Potentialism, and (iv) Pluralism. I discuss standard arguments and counterarguments concerning the positions and some of the natural mathematical programmes that are suggested by the various views.