Despite the recent discovery that thalidomide causes limb defects by targeting highly angiogenic, immature blood vessels, several challenges still remain and new ones have arisen. These include understanding the drug's species specificity, determining molecular target(s) in the endothelial cell, shedding light on the molecular basis of phocomelia and producing a form of the drug that is clinically effective without having side effects. Now that the trigger of thalidomide‐induced teratogenesis has been uncovered, a framework is proposed, incorporating and uniting previous models (...) of thalidomide action, explaining how thalidomide causes not just limb defects, but also all the other defects it induces. (shrink)

The concept of luck has played an important role in debates concerning free will and moral responsibility, yet participants in these debates have relied upon an intuitive notion of what luck is. Neil Levy develops an account of luck, which is then applied to the free will debate. He argues that the standard luck objection succeeds against common accounts of libertarian free will, but that it is possible to amend libertarian accounts so that they are no more vulnerable to (...) luck than is compatibilism. But compatibilist accounts of luck are themselves vulnerable to a powerful luck objection: historical compatibilisms cannot satisfactorily explain how agents can take responsibility for their constitutive luck; non-historical compatibilisms run into insurmountable difficulties with the epistemic condition on control over action. Levy argues that because epistemic conditions on control are so demanding that they are rarely satisfied, agents are not blameworthy for performing actions that they take to be best in a given situation. It follows that if there are any actions for which agents are responsible, they are akratic actions; but even these are unacceptably subject to luck. Levy goes on to discuss recent non-historical compatibilisms, and argues that they do not offer a viable alternative to control-based compatibilisms. He suggests that luck undermines our freedom and moral responsibility no matter whether determinism is true or not. (shrink)

What makes an argument in a law case good or bad? This book examines this and other questions central to the study of jurisprudence. Care has been taken to make the legal elements of the book readily accessible to non-lawyers, and the philosophical elements to non-philosophers.

Suppose that one thinks that certain symmetries of a theory reveal “surplus structure”. What would a formalism without that surplus structure look like? The conventional answer is that it would be a reduced theory: a theory which traffics only in structures invariant under the relevant symmetry. In this paper, I argue that there is a neglected alternative: one can work with a sophisticated version of the theory, in which the symmetries act as isomorphisms.

Causal exclusion arguments are taken to threaten the autonomy of the special sciences, and the causal efficacy of mental properties. A recent line of response to these arguments has appealed to “independently plausible” and “well grounded” theories of causation to rebut key premises. In this paper I consider two papers which proceed in this vein and show that they share a common feature: they both require causes to be proportional to their effects. I argue that this feature is a bug, (...) and one that generalises: any attempt to rescue the autonomy of the special sciences, or the efficacy of the mental, from exclusion worries had better not look to proportionality for help. (shrink)

The recent debate over the moral responsibility of psychopaths has centered on whether, or in what sense, they understand moral requirements. In this paper, I argue that even if they do understand what morality requires, the content of their actions is not of the right kind to justify full-blown blame. I advance two independent justifications of this claim. First, I argue that if the psychopath comes to know what morality requires via a route that does not involve a proper appreciation (...) of what it means to cause another harm or distress, the content of violations of rules against harm will be of a lower grade than the content of similar actions by normal individuals. Second, I argue that in order to intend a harm to a person—that is, to intend the distinctive kind of harm that can only befall a person—it is necessary to understand what personhood is and what makes it valuable. The psychopath's deficits with regard to mental time travel ensure that s/he cannot intend this kind of harm. (shrink)

In this chapter, we argue for three theses: (1) we lack the power to form beliefs at will (i.e., directly); at very least, we lack the power to form at will beliefs of the kind that proponents of doxastic voluntarism have in mind; but (2) we possess a propensity to form beliefs for non-epistemic reasons; and (3) these propensities—once we come to know we have them—entail that we have obligations similar to those we would have were doxastic voluntarism true. Specifically, (...) we will argue that we have obligations to avoid triggering these propensities to form beliefs that are unwarranted or even immoral. (shrink)

Neil Van Leeuwen argues that many religious people do not act and infer as we would expect believers to act and infer, and on this basis argues that they are not genuine believers. They take some other, nondoxastic, attitude to the claims they profess to believe. In this short commentary, I argue that in many (but far from all) such cases, the content, and not the attitude, explains the departures from the inferential and behavioral stereotype we associate with belief.

This paper outlines a new metasemantic theory of moral reason statements, focused on explaining how the reasons thus stated can be inescapable. The motivation for the theory is in part that it can explain this and other phenomena concerning moral reasons. The account also suggests a general recipe for explanations of conceptual features of moral reason statements. (Published with Open Access.).

This paper examines the prospects for a conceptual or functional role theory of moral concepts. It is argued that such an account is well-placed to explain both the irreducibility and practicality of moral concepts. Several versions of conceptual role semantics for moral concepts are distinguished, depending on whether the concept-constitutive conceptual roles are wide or narrow normative or non-normative and purely doxastic or conative. It is argued that the most plausible version of conceptual role semantics for moral concepts involves only (...) ‘narrow’ conceptual roles, where these include connections to motivational, desire-like, states. In the penultimate section it is argued, contrary to what Wedgwood, Enoch and others have claimed, that such an account of moral concepts cannot plausibly be combined with the claim that moral concepts refer to robust properties. (Published with Open Access.). (shrink)

Nietzsche holds that one should believe what best promotes life, and he also accepts the correspondence theory of truth. I’ll call this conjunction of views Nietzschean pragmatism. This article provides textual evidence for attributing this pragmatist position to Nietzsche and explains how his broader metaethical views led him to it.The following section introduces Nietzschean pragmatism, discussing how Nietzsche expresses it in BGE, and distinguishing it from William James’s pragmatism about truth. The second section explains how Nietzsche’s skepticism about values that (...) can’t be grounded in individual passion attracted him to this kind of pragmatism. The third section explores an early application of Nietzschean... (shrink)

There is an ongoing debate about the “ontology” of consent. Some argue that it is a mental act, some that it is a “hybrid” of a mental act plus behaviour that signifies that act; others argue that consent is a performative, akin to promising or commanding. Here it is argued that all these views are mistaken—though some more so than others. We begin with the question whether a normatively efficacious act of consent can be completed in the mind alone. Standard (...) objections to this “mentalist” account of consent can be rebutted. Here we identify a much deeper problem for mentalism. Normatively transformative acts of consent change others’ reasons for acting in a distinctive—“robust”—way. Robust reason-changing involves acts aimed at fulfilling a distinctive kind of reflexive and recognition-directed intention. Such acts cannot be coherently performed in the mind alone. Consent is not a mental act, but nor is it the signification of such an act. Acts of consent cannot be “completed” in the mind, and it is a mistake to view consent behaviour as making known a completed act of consent. The robust reason-changing account of consent developed here shares something with the performative theory, but is not saddled with a label whose home is philosophy of language. Certain kinds of performative utterance may change reasons robustly, but not all robust reason-changing involves or requires acts of speech, and consent can be effected by a wide range of behavioural acts. (shrink)

What is it for an event not to occur? This is an urgent, yet under explored, question for counterfactual analyses of causation quite generally. In this paper I take a lead from Lewis in identifying two different possible standards of non-occurrence that we might adopt and I argue that we need to apply them asymmetrically: one standard for the cause, another for the effect. This is a surprising result. I then offer a contextualist refinement of the Lewis approach in light (...) of initial problems, and discuss how the asymmetry remained hidden until now. I then relate the non-occurrence problem to issues of transitivity and proportionality in causation, before showing that a parallel problem exists for contrastivist and interventionist approaches to causation too. (shrink)

According to phenomenal particularism, external particulars are sometimes part of the phenomenal character of experience. Mehta criticizes this view, and French and Gomes :451–460, 2016) have attempted to show that phenomenal particularists have the resources to respond to Mehta’s criticisms. We argue that French and Gomes have failed to appreciate the force of Mehta’s original arguments. When properly interpreted, Mehta’s arguments provide a strong case in favor of phenomenal generalism, the view that external particulars are never part of phenomenal character.

This essay explains why partisanship is justified in contemporary America and environments with similar voting systems and coalition structures. It explains how political parties operate, how helping a party succeed can be a goal of genuine ethical significance, and how trusting one party while mistrusting another can be a reliable route to true belief about important political issues.

If we are to understand why psychoanalysis extends ordinary psychology in the precise ways that it does, we must take account of the existence of, and the interplay between, two distinct kinds of explanatory concern: functional and idiographic. The form and content of psychoanalytic explanation and its unusual methodology can, at least in part, be viewed as emerging out of Freud's attempt to reconcile these two types of explanatory concern. We must also acknowledge the role of the background theoretical context (...) that shapes Freud's functional thinking about the mind. A neglect of the role of the background theory in shaping the extension of ordinary psychology leaves us with puzzles about the nature and direction of the psychoanalytic extension and gives rise to an unbelievable history of psychoanalysis. (shrink)

This chapter explains an approach to relevantization of logical reasoning that seeks to maximize epistemic gain. It does so by retaining Disjunctive Syllogism and making admissible only a restricted rule of Cut. The virtue of this approach is that one can show that the resulting relevant logic is adequate for mathematics and science. In the course of explaining this kind of relevant logic, we compare and contrast our approach with the Anderson-Belnap tradition.

The rising profile of the environment in politics reflects growing public concern that we may be facing a large-scale ecological crisis. This unique textbook surveys the politics of the environment, providing a comprehensive and comparative introduction to ideas, activism and policy. Part One explores environmental philosophy and green political thought, assessing the relationship between 'green ideas' and other political doctrines. Part Two considers parties and movements, including the development of green parties from protest parties, the response of established political parties (...) to the environmental challenge, and the evolution of the environmental movement. Part Three analyses public policy-making and environmental issues at the international, national and local levels. As well as considering a wide variety of examples from around the world, this important new textbook includes glossary, lists of key issues, chapter summaries and guides to further study. (shrink)

If we are to understand why psychoanalysis extends ordinary psychology in the precise ways that it does, we must take account of the existence of, and the interplay between, two distinct kinds of explanatory concern: functional and idiographic. The form and content of psychoanalytic explanation and its unusual methodology can, at least in part, be viewed as emerging out of Freud's attempt to reconcile these two types of explanatory concern. We must also acknowledge the role of the background theoretical context (...) that shapes Freud's functional thinking about the mind. A neglect of the role of the background theory in shaping the extension of ordinary psychology leaves us with puzzles about the nature and direction of the psychoanalytic extension and gives rise to an unbelievable history of psychoanalysis. (shrink)

Chance inevitably plays a role in law but it is not often that we consciously try to import an element of randomness into a legal process. Random Justice: On Lotteries and Legal Decision-Making explores the potential for the use of lotteries in social, and particularly legal, decision-making contexts. Utilizing a variety of disciplines and materials, Neil Duxbury considers in detail the history, advantages, and drawbacks of deciding issues of social significance by lot and argues that the value of the (...) lottery as a legal decision-making device has generally been underestimated. The very fact that there exists widespread resistance to the use of lotteries for legal decision-making purposes betrays a commonly held belief that legal processes are generally more important than are legal outcomes. Where, owing to the existence of indeterminacy, the process of reasoning is likely to be excessively protracted and the reasons provided strongly contestable, the most cost-efficient and impartial decision-making strategy may well be recourse to lot. Aversion to this strategy, while generally understandable, is not necessarily rational. Yet in law, as Professor Duxbury demonstrates, reason is generally valued more highly than is rationality. The lottery is often conceived to be a decision-making device that operates in isolation. Yet lotteries can frequently and profitably be incorporated into other decision-frameworks. The book concludes by controversially considering how lotteries might be so incorporated and also advances the thesis that it may sometimes be sensible to require that adjudication takes place in the shadow of a lottery. (shrink)

Moral judgments entail or consist in claims that certain ways of behaving are called for. These actions have expectable consequences. I will argue that these consequences are suspiciously benign: on controversial issues, each side assesses these consequences, measured in dispute-independent goods, as significantly better than the consequences of behaving in the ways their opponents recommend. This remains the case even when we have not formed our moral judgment by assessing consequences. I will suggest that the evidence indicates that our perception (...) of the consequences of acting as recommended by our moral judgments is motivated, such that the warrant of such assessments is lower than we might have thought. The suspicion correlation between our moral judgments and our assessments of the implicated facts provides higher-order evidence that should lead us to reduce our confidence in these assessments. (shrink)

As pervasive as the use of the Internet has become in the United States, a huge percentage of the world’s population has yet to ever use a telephone. It seems ironic, then, that there is a concerted effort on the part of industrialized nations to first hook up their traditionally disadvantaged citizens to the Internet and second, to hook up citizens of developing nations. This paper addresses the universal access phenomenon by considering the growth of the Internet in terms of (...) Leaver and Taker users—idioms usually associated with a culture’s interactions with its environment. Leaver cultures interact with their environment in a sustainable manner while Taker cultures produce more than they need and impose their ways upon others. The Internet is explored as a community of users, which in its current state is dominated by Takers. However, realizing the need for a more heterogeneous Internet community, this paper explores incentives for Leaver cultures to assimilate online and methods of improving interface designs to be more intuitive to Leaver communities. It is hoped that a tragedy of the commons of Internet resources can be avoided as more Leavers participate in the sustainment of the Internet as a valuable tool for all communities. (shrink)

This guide focuses on the content and form of excellent philosophical writing, with further comments on reading, thinking, writing processes, publication strategies, and self-cultivation.

Multiverse Views in set theory advocate the claim that there are many universes of sets, no-one of which is canonical, and have risen to prominence over the last few years. One motivating factor is that such positions are often argued to account very elegantly for technical practice. While there is much discussion of the technical aspects of these views, in this paper I analyse a radical form of Multiversism on largely philosophical grounds. Of particular importance will be an account of (...) reference on the Multiversist conception, and the relativism that it implies. I argue that analysis of this central issue in the Philosophy of Mathematics indicates that Radical Multiversism must be algebraic, and cannot be viewed as an attempt to provide an account of reference without a softening of the position. (shrink)

Journal of Philosophy of Education, Volume 55, Issue 1, Page 83-98, February 2021.

Which is worse: Doing evil or being evil? If we are free to define ourselves through our choices, as existentialism posits, then the latter is worse. This paper attempts to resolve the issue of the difference between religious (group) ethics and the ethics of a person of faith that embraces individuals with an existential understanding. In the existential view, the individual (whether the self or the other) is the primary concern, and so the issue of personal relational morality supersedes religious (...) narratives, social morality and popular ethics (White, 2002). If we think and choose, there is the possibility that we may occasionally make a mistake and do evil. However, if we do not think about our choices, and if the conventions we hold happen to be flawed in some way, then we become defined by a continual cycle of mistakes. Existentialism teaches that we become who we are in the process of making choices; therefore the difference between doing evil and being evil can be found in the small but important flow of thinking, relating and choosing. (shrink)

Scholars from the Global North have consistently facilitated research in the Global South, particularly with war-affected young people (Bragin et al. 2014) living in refugee camps (Cooper 2005). Th...

"16 'On Justification and Interpretation', ARSP-Beiheft, 53, pp. 255-68." -- "17 'Authority Reasons in Legal Interpretation and Moral Reasoning', ARSP Supplementa (III), pp. 144-52." -- "18 'Two Types of Substantive Reasons: The Core of a Theory of Common-Law Justification', Cornell Law Review, 63, pp. 707-88." -- "19 'Reasonableness and Objectivity', Notre Dame Law Review, 74, pp. 1575-603.

There has recently been debate in the literature over whether the metaphysical doctrine popularly known as Humean supervenience can be reconciled—in whole or in part—with certain empirical facts about quantum entanglement. In this paper, I undertake a critical analysis of Humean efforts to effect such a reconciliation. I begin with a discussion of the relationship between Humeanism and quantum mechanics; I suggest that there are some difficulties even when considering single-particle quantum mechanics, but agree that the real problems come when (...) considering many-particle quantum mechanics. I then review the available strategies for overcoming this problem, and find them wanting. (shrink)

He also tells a very interesting personal story of his battles to get these trajectories used, and how he was able to save the Hiten spacecraft and get it to the moon. This is a great story, and he tells it very well.