Despite the recent discovery that thalidomide causes limb defects by targeting highly angiogenic, immature blood vessels, several challenges still remain and new ones have arisen. These include understanding the drug's species specificity, determining molecular target(s) in the endothelial cell, shedding light on the molecular basis of phocomelia and producing a form of the drug that is clinically effective without having side effects. Now that the trigger of thalidomide‐induced teratogenesis has been uncovered, a framework is proposed, incorporating and uniting previous models (...) of thalidomide action, explaining how thalidomide causes not just limb defects, but also all the other defects it induces. (shrink)

Neil Van Leeuwen argues that many religious people do not act and infer as we would expect believers to act and infer, and on this basis argues that they are not genuine believers. They take some other, nondoxastic, attitude to the claims they profess to believe. In this short commentary, I argue that in many (but far from all) such cases, the content, and not the attitude, explains the departures from the inferential and behavioral stereotype we associate with belief.

Noam Chomsky is one of the leading intellectual figures of modern times. He has had a major influence on linguistics, psychology and philosophy, and a significant effect on many other disciplines, from anthropology to mathematics, education to literary criticism. In this rigorous yet accessible account of Chomsky's work and influence, Neil Smith analyses Chomsky's key contributions to the study of language and the study of mind. He gives a detailed exposition of Chomsky's linguistic theorizing, discusses the psychological and philosophical (...) implications of Chomsky's work, and argues that he has fundamentally changed the way we think of ourselves, gaining a position in the history of ideas on a par with that of Darwin or Descartes. This second edition has been thoroughly updated to account for Chomsky's most recent work, including his continued contributions to linguistics, his further discussion on evolution, and his extensive work on the events of September 11th, 2001. (shrink)

This paper presents two cases demonstrating that theories allowing the environment to partially determine the content of moral concepts provide incorrect truth-conditions for moral terms. While typical Moral Twin Earth cases seek to establish that these theories fail to account formoral disagreement, neither case here essentially involves interpersonal disagreement. Both involve a single person retaining moral beliefs despite recognizing actual or potential mismatches with the purportedly content-determining facts. This lets opponents of such theories grant objections that standard Moral Twin Earth (...) cases fail to demonstrate disagreement, and argue more straightforwardly that they generate implausible truth-conditions for moral claims. (shrink)

It is standard in set theory to assume that Cantor's Theorem establishes that the continuum is an uncountable set. A challenge for this position comes from the observation that through forcing one can collapse any cardinal to the countable and that the continuum can be made arbitrarily large. In this paper, we present a different take on the relationship between Cantor's Theorem and extensions of universes, arguing that they can be seen as showing that every set is countable and that (...) the continuum is a proper class. We examine several principles based on maximality considerations in this framework, and show how some (namely Ordinal Inner Model Hypotheses) enable us to incorporate standard set theories (including ZFC with large cardinals added). We conclude that the systems considered raise questions concerning the foundational purposes of set theory. (shrink)

Let's suppose you think that there are no uncountable sets. Have you adopted a restrictive position? It is certainly tempting to say yes---you've prohibited the existence of certain kinds of large set. This paper argues that this intuition can be challenged. Instead, I argue that there are some considerations based on a formal notion of restrictiveness which suggest that it is restrictive to hold that there are uncountable sets.

In the contemporary philosophy of set theory, discussion of new axioms that purport to resolve independence necessitates an explanation of how they come to be justified. Ordinarily, justification is divided into two broad kinds: intrinsic justification relates to how `intuitively plausible' an axiom is, whereas extrinsic justification supports an axiom by identifying certain `desirable' consequences. This paper puts pressure on how this distinction is formulated and construed. In particular, we argue that the distinction as often presented is neither well-demarcated nor (...) sufficiently precise. Instead, we suggest that the process of justification in set theory should not be thought of as neatly divisible in this way, but should rather be understood as a conceptually indivisible notion linked to the goal of explanation. (shrink)

The biobank consent debate is one with deeply held convictions on both the ‘broad’ and ‘specific’ side with little sign of resolution. Recently, Thomas Ploug and Soren Holm have developed an alternative to both specific and broad consent: a meta‐consent framework. The aim here is to consider whether meta‐consent provides a ‘solution’ to the biobank consent debate. We clarify what ‘meta‐consent’ actually is (arguing that the label is a misnomer and ‘consent à la carte’ is more accurate). We identify problems (...) with Ploug and Holm's arguments, and some challenges for meta‐consent. We focus on whether there is any ethical obligation to provide consent à la carte. There may seem to be so, especially if we draw upon an unclear appeal to the ethical significance of ‘respect for autonomy’. Similarly, there might seem to be an intuitive inference from the fact that ethically legitimate research requires informed consent to the conclusion that it thereby requires consent à la carte. It is shown that this line of inference is mistaken. (shrink)

This article considers the following question: What is the relationship between supervenience and reduction? I investigate this formally: first, by introducing a recent argument by Christian List to the effect that one can have supervenience without reduction; then, by considering how the notion of Nagelian reduction can be related to the formal apparatus of definability and translation theory; then, by showing how, in the context of propositional theories, topological constraints on supervenience serve to enforce reducibility; and, finally, by showing how (...) constraints derived from the theory of ultraproducts can enforce reducibility in the context of first-order theories. (shrink)

A pervasive thought in contemporary philosophy of mathematics is that in order to justify reflection principles, one must hold universism: the view that there is a single universe of pure sets. I challenge this kind of reasoning by contrasting universism with a Zermelian form of multiversism. I argue that if extant justifications of reflection principles using notions of richness are acceptable for the universist, then the Zermelian can use similar justifications. However, I note that for some forms of richness argument, (...) the status of reflection principles as axioms is left open for the Zermelian. (shrink)

The independence phenomenon in set theory, while pervasive, can be partially addressed through the use of large cardinal axioms. A commonly assumed idea is that large cardinal axioms are species of maximality principles. In this paper I question this claim. I show that there is a kind of maximality (namely absoluteness) on which large cardinal axioms come out as restrictive relative to a formal notion of restrictiveness. Within this framework, I argue that large cardinal axioms can still play many of (...) their usual foundational roles. (shrink)

The contemporary concept of place rests on a paradox: in order to move seamlessly within and between places (real and virtual), one must possess a secure—primarily, legal and economic—connection to a place. Without this secure connection, being-in-the-world means being displaced. By drawing on examples in literature, anthropology, and the testimonies of displaced persons, this chapter illustrates that an over-insistence on the ontological primordiality of place potentially aligns phenomenology with the exclusionary dimension of place in the globalized 21st century. In response, (...) I construct a critical phenomenology of forced displacement that is at once critical of the phenomenology of place, but also views phenomenology as critical to overcoming the contemporary paradox of place. (shrink)

The current study investigates how native speakers of a morphologically complex language handle uncertainty related to linguistic forms that have gaps in their inflectional paradigms. We analyze their strategies of dealing with paradigmatic defectivity and how these strategies are motivated by subjective contemporaneousness, frequency, acceptability, and other lexical and structural characteristics of words. We administered a verb production task with Finnish native speakers using verbs from a small non-productive inflectional type that has many paradigmatic gaps and asked participants to inflect (...) the verbs in a given context. Inflectional uncertainty was measured by the number of different forms the participants produced for each verb. We classified produced forms that were not expected as either synonymous or novel and measured their optimal string alignment distance to expected forms. Our analyses revealed that a usage-based approach to paradigmatic defectivity fits better with the obtained results than a classical approach typically met in dictionaries and descriptive grammars. Thus, we argue, that paradigmatic defectivity can be better described as a dynamic rather than a static system, where gaps represent a continuum of possible inflectional choices rather than a lack of an inflectional variant. (shrink)

Moral judgments entail or consist in claims that certain ways of behaving are called for. These actions have expectable consequences. I will argue that these consequences are suspiciously benign: on controversial issues, each side assesses these consequences, measured in dispute-independent goods, as significantly better than the consequences of behaving in the ways their opponents recommend. This remains the case even when we have not formed our moral judgment by assessing consequences. I will suggest that the evidence indicates that our perception (...) of the consequences of acting as recommended by our moral judgments is motivated, such that the warrant of such assessments is lower than we might have thought. The suspicion correlation between our moral judgments and our assessments of the implicated facts provides higher-order evidence that should lead us to reduce our confidence in these assessments. (shrink)

In “The Evolutionary Debunking of Quasi-Realism,” Neil Sinclair and James Chamberlain present a novel answer that quasi-realists can pro-vide to a version of the reliability challenge in ethics—which asks for an explanation of why our moral beliefs are generally true—and in so doing, they examine whether evolutionary arguments can debunk quasi-realism. Although reliability challenges differ from EDAs in several respects, there may well be a connection between them. For the explanatory premise of an EDA may state that a particular (...) theory of beliefs of a certain kind does not, or cannot, provide a plausible account of why those beliefs might be generally true, and its epistemic premise may state that, if that is the case, then the beliefs in question have a negative epistemic status or the theory is false inasmuch as, if it were true, it would lead to those beliefs having such a negative epistemic status. The quasi-realist can answer the reli-ability challenge by claiming that, when we form our moral beliefs through a process of well-informed impartial reflection, we form them in response to the non-moral features of things on which depend the moral features they have. Hence, when we form beliefs by means of such a process, we are most likely forming true moral beliefs. (shrink)

ABSTRACT In A Metaphysics for Freedom and related papers, Helen Steward advances a new argument for incompatibilism. Though she concedes that the luck objection is persuasive with regard to existing versions of libertarianism, she claims that agency itself is incompatible with determinism: we are only agents at all if we are able to settle matters concerning our movements, where settling something requires that prior to our settling it lacked sufficient conditions. She argues that genuine agents settle very fine-grained aspects of (...) their movements: when and how they move, even when and how their neurons fire. In this paper, I advance two linked arguments against agency incompatibilism. I argue, first, that we do not exercise direct control over the fine-grained aspects of our movements. Rather, we control these movements indirectly, by intentionally engaging in broadly individuated action types. Second, I argue that these aspects of our movements are lucky for us and, since this is true, they cannot play the role of grounding our agency. (shrink)

As pervasive as the use of the Internet has become in the United States, a huge percentage of the world’s population has yet to ever use a telephone. It seems ironic, then, that there is a concerted effort on the part of industrialized nations to first hook up their traditionally disadvantaged citizens to the Internet and second, to hook up citizens of developing nations. This paper addresses the universal access phenomenon by considering the growth of the Internet in terms of (...) Leaver and Taker users—idioms usually associated with a culture’s interactions with its environment. Leaver cultures interact with their environment in a sustainable manner while Taker cultures produce more than they need and impose their ways upon others. The Internet is explored as a community of users, which in its current state is dominated by Takers. However, realizing the need for a more heterogeneous Internet community, this paper explores incentives for Leaver cultures to assimilate online and methods of improving interface designs to be more intuitive to Leaver communities. It is hoped that a tragedy of the commons of Internet resources can be avoided as more Leavers participate in the sustainment of the Internet as a valuable tool for all communities. (shrink)

I provide an examination and comparison of modal theories for underwriting different non-modal theories of sets. I argue that there is a respect in which the `standard' modal theory for set construction---on which sets are formed via the successive individuation of powersets---raises a significant challenge for some recently proposed `countabilist' modal theories (i.e. ones that imply that every set is countable). I examine how the countabilist can respond to this issue via the use of regularity axioms and raise some questions (...) about this approach. I argue that by comparing them with the `standard' uncountabilist theory, a new approach that brings in arbitrariness rather than the strict controls of forcing is desirable. (shrink)

Of the many futuristic prospects offered by neuroscience, one of the more controversial is ‘brain reading’: the use of functional neuroimaging to gain information about subjects’ mental states or thoughts. This technology has various possible applications, including ‘neuromarketing’ and lie detection. Would such applications violate subjects’ privacy rights? Conversely, if God knows and judges all our secret thoughts, do Christians have any stake in defending a right to mental privacy? This article argues that God’s knowledge of us is different not (...) only in degree but in kind from the knowledge sought through brain reading. This view of divine knowledge supports a theological account of privacy, richer and broader in scope than standard accounts of privacy rights, which can aid the ethical analysis of the use of brain reading technology for purposes such as marketing and lie detection. (shrink)

Journal of Philosophy of Education, Volume 55, Issue 1, Page 83-98, February 2021.

How might Roland Barthes’ posthumously published account of the Neutral invite us to rethink the very activity of cultural analysis? How did Barthes the cultural critic change when, towards the end of his career, he described and desired Neutral Life? Cultural criticism has often taken Barthes’ early semiological work as a guide, but this essay examines how we might need to reorient ourselves as critics, shift our stance, learn to look and live differently in the light of Barthes’ later focus (...) on the Neutral. (shrink)

How does our language relate to reality? This is a question that is especially pertinent in set theory, where we seem to talk of large infinite entities. Based on an analogy with the use of models in the natural sciences, we argue for a threefold correspondence between our language, models, and reality. We argue that so conceived, the existence of models can be underwritten by a weak notion of existence, where weak existence is to be understood as existing in virtue (...) of language. (shrink)

Scholars from the Global North have consistently facilitated research in the Global South, particularly with war-affected young people (Bragin et al. 2014) living in refugee camps (Cooper 2005). Th...

Which is worse: Doing evil or being evil? If we are free to define ourselves through our choices, as existentialism posits, then the latter is worse. This paper attempts to resolve the issue of the difference between religious (group) ethics and the ethics of a person of faith that embraces individuals with an existential understanding. In the existential view, the individual (whether the self or the other) is the primary concern, and so the issue of personal relational morality supersedes religious (...) narratives, social morality and popular ethics (White, 2002). If we think and choose, there is the possibility that we may occasionally make a mistake and do evil. However, if we do not think about our choices, and if the conventions we hold happen to be flawed in some way, then we become defined by a continual cycle of mistakes. Existentialism teaches that we become who we are in the process of making choices; therefore the difference between doing evil and being evil can be found in the small but important flow of thinking, relating and choosing. (shrink)

Laypersons serve at critical junctures in the legal process. This article provides an overview of research about layperson roles and draws attention to the research methodologies used in studying them. It also discusses the jury system because, in addition to the fact that this institution has attracted the greatest quantity of empirical research on lay participation in legal processes, the studies have also involved the greatest range of methodological approaches, thus allowing exploration of their various strengths and weaknesses. Research on (...) mixed tribunals, lay magistrates, justices of the peace and other forms of lay participation are also discussed in the article. There are literally hundreds of empirical studies bearing on jury competence and behavior. More systematic research surveying the extent of layperson roles in different cultures and countries is needed and studies of how laypersons actually perform in these roles is crucial. (shrink)

In this article I examine what happens to the “I” when the other disappears. I elucidate the relationship between ontic – relational ties to specific others – and ontological relationality – the fundamental relationality that facilitates the very existence of the “I.” The loss of an ontic relationality, I contend, ensures that the “I” can never be the same as it was prior to the loss. But the disappearance of an ontic relationality also accentuates that the “I” cannot disavow its (...) ontological relationality, despite the pain and suffering brought about by the loss of a specific other. I argue that exposure to this ontological relationality, through the deprivation of an ontic one, offers us the opportunity to re-think habituated and potentially damaging forms of relationality, particularly in an age when neoliberal rationality encourages us to turn away from the other and to seek shelter in the self. To explicate the chiastic relationship between ontic and ontological relationality, I draw on Maurice Merleau-Ponty’s concept of the “hinge,” Judith Butler’s work on grief and mourning, and Emmanuel Levinas’s notion of the “face.” By looking specifically at remembrance campaigns for victims of forced disappearance – particularly in Guatemala and Argentina – I show how faces of the disappeared continue to haunt the political present in ways that refuse the fantasy of a return to a former order. In doing so, these campaigns keep exposing us to the ontological relationality that underpins all human life, encouraging us to find new ways of relating that transcend our habituated and repetitive relational behaviours. This exposure, I argue, illustrates that no amount of self-sufficiency allows us to escape the ontological necessity of relationality. The disappearance of the other, any other, discloses the fraudulent anti-relationality of the neoliberal era by revealing the ties that connect beings together. This disclosure, I conclude, constitutes the importance of the relationality of disappearance. -/- . (shrink)

This article approaches defective and overabundant paradigm cells as an opportunity and pitfall for usage-based linguistics. Through reference to two production tasks involving native speakers of Czech, we show how definitions of these two categories are problematized when multiple forms per context are entrenched, or when pre-emption seems to occur in the absence of entrenchment: in other words, pre-emption occurs via entrenchment of uncertainty. We explain the results by adopting a broader, usage-based perspective. We examine the relationship between frequency (as (...) proxy for exposure) and reference-work information (as proxy fora prioristructure) to assess their connection with our experimental results. We assign a role to frequency as helping to form perceptions of “suitable” and “unsuitable” forms, but also note places where non-frequency factors predominate. “Structure” as represented by reference-work recommendations appears to have no significant connection to our experimental results; we discuss reasons for this. (shrink)

Rejecting the notion that Picasso's representations of faces should always be considered in a biographical context as portraits, it is argued that in considering them as human faces we encounter a crisis in the idea of an essential humanity. The essay then discusses Picasso's faces relation to Georges Bataille's treatment of vernacular portrait photography and of animality in human emotional expression, arguing that Picasso's human faces court the inhuman. This inhuman countenance, bred so effectively in the artist's work in the (...) 1930s and 1940s, raises in turn the question of the origin of the human in the inhuman. Turning to Bataille's discussion of the cave of Lascaux, discovered in 1940 and made to stand for the question of humanity posed so brutally by the war, the essay analyses the irruption of the origin of the human ideal in the sovereign act of the depiction of animality. A double refusal of destinies, of animality and of humanity, is caught before our eyes in such depictions. This temporal suspension of destinies is read back into Picasso's human faces. (shrink)

This paper addresses the question of how Robertson's History of America depicts the transition of world history from pre-modern disorder to a recognisably modern commercial order. It argues that in his narrative of action he moves beyond the limitations imposed by stadial forms of history, with which America is usually associated, and displays the importance of disordered forms of activity as a creative force in shaping the modern world. It concludes by suggesting that a close reading of his history does (...) not support Robertson's assumptions concerning the formation of a stable, ordered and industrious ‘commercial character’ out of this process, but rather establishes a more complex and less teleological path to modernity. ☆ This paper was presented in abbreviated form at the conference on ‘Political Economy and 18th Century Scottish Culture’ at George Mason University, June 2001. The author wishes to thank all those who contributed to the panel on William Robertson, especially Ingrid Merikoski and Jan Cleaver. (shrink)

This chapter argues that contemporary literary criticism suffers from a reflexive faith in things, conceived broadly as static objects that reflect wider political, social, and cultural practices. Literature is re-imagined here as an open-ended event that demands an immanent materialism in which distinctions between literary objects and human bodies no longer stand up. By reflecting on the ambiguous “thing-ness” of Shakespeare, Vallelly draws attention to the elusive nature of things in theatrical spaces, and explores how this enigmatic materiality can be (...) applied to literary experience more generally. To do so, he draws on Roberto’s Bolaño’s 2666, affect theory, and new materialism to construct a new literary materialism, one in which literary meaning is located neither in the human nor in the non-human world, but in the affective correspondence between these worlds. To illustrate this point, the chapter concludes with a discussion of the relationship between characters and stones in Shakespearean drama. (shrink)

This volume presents those writings of Marx that best reveal his contribution to sociology, particularly to the theory of society and social change. The editor, Neil J. Smelser, has divided these selections into three topical sections and has also included works by Friedrich Engels. The first section, "The Structure of Society," contains Marx's writings on the material basis of classes, the basis of the state, and the basis of the family. Among the writings included in this section are Marx's (...) well-known summary from the Preface of _A Contribution to a Critique of Political Economy_ and his equally famous observations on the functional significance of religion in relation to politics. The second section is titled "The Sweep of Historical Change." The first selection here contains Marx's first statement of the main precapitalist forms of production. The second selection focuses on capitalism, its contradictions, and its impending destruction. Two brief final selections treat the nature of communism, particularly its freedom from the kinds of contradictions that have plagued all earlier forms of societies. The last section, "The Mechanisms of Change," reproduces several parts of Marx's analysis of the mechanisms by which contradictions develop in capitalism and generate group conflicts. Included is an analysis of competition and its effects on the various classes, a discussion of economic crises and their effects on workers, and Marx's presentation of the historical specifics of the class struggle. In his comprehensive Introduction to the selections, Professor Smelser provides a biography of Marx, indentifies the various intellectual traditions which formed the background for Marx's writings, and discusses the selections which follow. The editor describes Marx's conception of society as a social system, the differences between functionalism and Marx's theories, and the dynamics of economic and political change as analyzed by Marx. (shrink)

"16 'On Justification and Interpretation', ARSP-Beiheft, 53, pp. 255-68." -- "17 'Authority Reasons in Legal Interpretation and Moral Reasoning', ARSP Supplementa (III), pp. 144-52." -- "18 'Two Types of Substantive Reasons: The Core of a Theory of Common-Law Justification', Cornell Law Review, 63, pp. 707-88." -- "19 'Reasonableness and Objectivity', Notre Dame Law Review, 74, pp. 1575-603.

This collection of essays, published to coincide with Tony Honore's sixty-fifth birthday, focuses on the areas where Honore's thought has made the most significant contribution: Roman law and jurisprudence. Included are essays by P.S. Atiyah, Zenon Bankowski, John Bell, Peter Birks, John W. Cairs, Hugh Collins, David Daube, W. M. Gordon, J. W. Harris Nicola Lacey, A. D. E. Lewis, Detlef Liebs, G. D. MacCormack, Neil MacCormick, G. Maher, Pieter Norr, Alan Rodger, and Peter Stein.

In this paper, I offer a new argument for the perceptual rationality thesis: the claim that perceptual experiences themselves can be rational or irrational. In her book The Rationality of Perception, Susanna Siegel has offered several intertwined arguments for this same thesis, and, as you will see, one of Siegel’s arguments is what inspires my own. However, I will suggest that the new argument is significantly better-supported than Siegel’s original argument.

James Lasdun’s memoir of being stalked, Give Me Everything You Have, has provoked considerable controversy. Whilst the quality of the writing is widely praised, some critics object to the way Lasdun documents in unsparing detail his experiences without taking any account of the stalker’s apparent mental health problems. There are ethical and conceptual problems with Lasdun’s approach, but side-stepping medical knowledge and relying on what we might call common sense help Lasdun to find ways to interpret his stalker’s actions as (...) meaningful and human. I suggest three interlinked implications concerning: medicalization, stigma, and the relationship between ethics and scientific knowledge. (shrink)

In the light of the publication of Roland Barthes's Mourning Diary, this essay examines how the influential theory of the photographic punctum has cinematic roots which are repressed in Barthes's Camera Lucida. My aim is not to repeat familiar arguments about how Barthes's ‘The Third Meaning’ anticipates the photographic punctum in a cinematic context; it is, rather, to attend specifically to Mourning Diary as a much closer, more precise precursor which has been visible only since 2009, and which casts new (...) light upon the work of Roland Barthes. (shrink)