Despite the recent discovery that thalidomide causes limb defects by targeting highly angiogenic, immature blood vessels, several challenges still remain and new ones have arisen. These include understanding the drug's species specificity, determining molecular target(s) in the endothelial cell, shedding light on the molecular basis of phocomelia and producing a form of the drug that is clinically effective without having side effects. Now that the trigger of thalidomide‐induced teratogenesis has been uncovered, a framework is proposed, incorporating and uniting previous models (...) of thalidomide action, explaining how thalidomide causes not just limb defects, but also all the other defects it induces. (shrink)

The concept of luck has played an important role in debates concerning free will and moral responsibility, yet participants in these debates have relied upon an intuitive notion of what luck is. Neil Levy develops an account of luck, which is then applied to the free will debate. He argues that the standard luck objection succeeds against common accounts of libertarian free will, but that it is possible to amend libertarian accounts so that they are no more vulnerable to (...) luck than is compatibilism. But compatibilist accounts of luck are themselves vulnerable to a powerful luck objection: historical compatibilisms cannot satisfactorily explain how agents can take responsibility for their constitutive luck; non-historical compatibilisms run into insurmountable difficulties with the epistemic condition on control over action. Levy argues that because epistemic conditions on control are so demanding that they are rarely satisfied, agents are not blameworthy for performing actions that they take to be best in a given situation. It follows that if there are any actions for which agents are responsible, they are akratic actions; but even these are unacceptably subject to luck. Levy goes on to discuss recent non-historical compatibilisms, and argues that they do not offer a viable alternative to control-based compatibilisms. He suggests that luck undermines our freedom and moral responsibility no matter whether determinism is true or not. (shrink)

Public support for responses to the coronavirus pandemic has sharply diverged on partisan lines in many countries, with conservatives tending to oppose lockdowns, social distancing, mask mandates and vaccines, and liberals far more supportive. This polarization may arise from the way in which the attitudes of each side is echoed back to them, especially on social media. In this paper, I argue that echo chambers are not to blame for this polarization, even if they are causally responsible for it. They (...) are not to blame, because belief calibration in an echo chamber is a rational process; moreover, the epistemically constitutive properties of echo chambers are not optional for epistemically social animals like us. There is no special problem of echo chambers; rather, there is a problem of misleading evidence (especially higher-order evidence). Accordingly, we ought to respond to misinformation about COVID neither by attempting to dismantle echo chambers nor by attempting to make people more rational, but rather by attempting to supplant unreliable higher-order evidence with better evidence. (shrink)

Much of what we know we know through testimony, and knowing on the basis of testimony requires some degree of trust in speakers. Trust is therefore very valuable. But in trusting, we expose ourselves to risks of harm and betrayal. It is therefore important to trust well. In this paper, I discuss two recent cases of the betrayal of trust in (broadly) academic contexts: one involving hoax submissions to journals, the other faking an identity on social media. I consider whether (...) these betrayals suggest that we ought to be less trusting in contexts like these. I argue that we should not: the acquisition of knowledge is dependent on trust, and we cannot intentionally reduce the extent to which we trust in these kinds of contexts without risking destroying it utterly. Instead, we must trust in our epistemic networks and the way they work to filter out deception. (shrink)

We explain and explore class-theoretic potentialism—the view that one can always individuate more classes over a set-theoretic universe. We examine some motivations for class-theoretic potentialism, before proving some results concerning the relevant potentialist systems (in particular exhibiting failures of the $\mathsf {.2}$ and $\mathsf {.3}$ axioms). We then discuss the significance of these results for the different kinds of class-theoretic potentialists.

What is morality? In Practical Expressivism, I argue that morality is a purely natural interpersonal co-ordination device, whereby human beings express their attitudes in order to influence the attitudes and actions of others. -/- The ultimate goal of these expressions is to find acceptable ways of living together. This 'expressivist' model for understanding morality faces well-known challenges concerning 'saving the appearances' of morality, because morality presents itself to us as a practice of objective discovery, not pure expression. -/- This book (...) demonstrates how a properly developed expressivist view can overcome this objection, by showing that even if moral practice is fundamentally expressive, it can still come to possess those features that make it appear objective (features such as talk and thought of moral disagreement, truth and belief, and the applicability of logical notions to moral sentences). The key to this development is to emphasise the unique and intricate practical role that morality plays in our lives. Practical expressivism is also practical in the further sense that it provides repeatable patterns that expressivists can deploy in coming to understand the apparently objective features of morality. (shrink)

If a person is competent to consent to a treatment, is that person necessarily competent to refuse the very same treatment? Risk relativists answer no to this question. If the refusal of a treatment is risky, we may demand a higher level of decision-making capacity to choose this option. The position is known as asymmetry. Risk relativity rests on the possibility of setting variable levels of competence by reference to variable levels of risk. In an excellent 2016 article inJournal of (...) Medical Ethics(JME), Rob Lawlor defends asymmetry of this kind by defending risk relativity, using and developing arguments and approaches found in earlier work such as that of Wilks. He offers what we call the two-scale approach: a scale of risk is to be used to set a standard of competence on a scale of decision-making difficulty. However, can this be done in any rational way? We argue it cannot, and in this sense, and to this extent, risk relativity is a nonsense. (shrink)

In light of the growing need to pay attention to general public opinions and sentiments toward AI, this paper examines the levels of understandings amongst the Australian public toward the increased societal use of AI technologies. Drawing on a nationally representative survey of 2019 adults across Australia, the paper examines how aware people consider themselves to be of recent developments in AI; variations in popular conceptions of what AI is; and the extent to which levels of support for AI are (...) liable to alter with additional exposure to information about AI. While a majority of respondents consider themselves to have little knowledge and familiarity with the topic of AI, the survey nevertheless finds considerable range of relatively ‘plausible’ basic understandings of what AI is. Significantly, repeated questioning highlights a willingness among many people to reassess their opinions once having received further information about AI, and being asked to think through issues relating to AI and society. These patterns remain relatively consistent, regardless of respondents’ political orientation, income, social class and other demographic characteristics. As such, the paper concludes by considering how these findings provide support for the development of public education efforts to further enhance what might be termed ‘public understanding of AI’. (shrink)

Neil Van Leeuwen argues that many religious people do not act and infer as we would expect believers to act and infer, and on this basis argues that they are not genuine believers. They take some other, nondoxastic, attitude to the claims they profess to believe. In this short commentary, I argue that in many (but far from all) such cases, the content, and not the attitude, explains the departures from the inferential and behavioral stereotype we associate with belief.

Philosophy and Phenomenological Research, Volume 104, Issue 1, Page 209-231, January 2022.

Philosophy Compass, Volume 17, Issue 4, April 2022.

We are all apt to alter our beliefs and even our principles to suit the prevailing winds. Examples abound in public life, but we are all subject to similar reversals. We often accuse one another of hypocrisy when these kinds of reversals occur. Sometimes the accusation is justified. In this paper, however, I will argue that in many such cases, we don’t manifest hypocrisy, even if our change of mind is not in response to new evidence. Marshalling evidence from psychology (...) and evolutionary theory, I will suggest that we are designed to update our beliefs in response to social signals: as these signals change, we change our minds, often without even noticing. (shrink)

Naïve realism is a theory of perception with great explanatory ambitions. It has been influentially argued that, in order to realize these explanatory ambitions, the naïve realist should say that any perception belongs to just one fundamental kind. I think, however, that adopting this commitment does not particularly help the naïve realist to realize her explanatory ambitions, and so is not warranted. This result is significant because once this commitment about fundamental kinds is relinquished, we see that it is possible (...) to develop some new and surprising forms of naïve realism—most notably, what I call pluralist naïve realism. (shrink)

If categorical equivalence is a good criterion of theoretical equivalence, then it would seem that if some class of mathematical structures is represented as a category, then any other class of structures categorically equivalent to it will have the same representational capacities. Hudetz (2019a) has presented an apparent counterexample to this claim; in this note, I argue that the counterexample fails.

This essay discusses the moral costs and benefits of sexual technology. It starts with first-wave sexual technology, such as dating apps, messaging apps, and social networks, and then discusses second-wave sexual technology, which offers users more immersive experiences, such as virtual reality and sex robots. The paper argues that, overall, such technologies provide more benefits than they incur costs. Finally, the paper discusses the rise of a new identity—digisexuality, explaining that digisexuals are people who consider sexual technology an essential part (...) of who they are, and who might forego relationships with other people. The paper argues that the development of this new identity is a good thing, and that reasons against it are not convincing. (shrink)

To date, philosophical discussions of animal ethics and Critical Animal Studies have been dominated by Western perspectives and Western thinkers. This book makes a novel contribution to animal ethics in showing the range and richness of ideas offered to these fields by diverse Asian traditions. Asian Perspectives on Animal Ethics is the first of its kind to include the intersection of Asian and European traditions with respect to human and nonhuman relations. Presenting a series of studies focusing on specific Asian (...) traditions, as well as studies that put those traditions in dialogue with Western thinkers, this book looks at Asian philosophical doctrines concerning compassion and nonviolence as these apply to nonhuman animals, as well as the moral rights and status of nonhuman animals in Asian traditions. Using Asian perspectives to explore ontological, ethical and political questions, contributors analyze humanism and post-humanism in Asian and comparative traditions and offer insight into the special ethical relations between humans and other particular species of animals. This book will be of interest to students and scholars of Asian religion and philosophy, as well as to those interested in animal ethics and Critical Animal Studies. (shrink)

Neil Gascoigne provides the first comprehensive introduction Richard Rorty's work. He demonstrates to the general reader and to the student of philosophy alike how the radical views on truth, objectivity and rationality expressed in Rorty's widely-read essays on contemporary culture and politics derive from his earliest work in the philosophy of mind and language. He avoids the partisanship that characterizes much discussion of Rorty's work whilst providing a critical account of some of the dominant concerns of contemporary thought. Beginning (...) with Rorty's early work on concept-change in the philosophy of mind, the book traces his increasing hostility to the idea that philosophy is cognitively privileged with respect to other disciplines. After the publication of Philosophy and the Mirror of Nature, this led to a new emphasis on preserving the moral and political inheritance of the enlightenment by detaching it from the traditional search for rational foundations. This emerging project led Rorty to champion 'ironic' thinkers like Foucault and Derrida, and to his attempt to update the liberalism of J. S. Mill by offering a non-universalistic account of the individual's need to balance their own private interests against their commitments to others. By returning him to his philosophical roots, Gascoigne shows why Rorty's pragmatism is of continuing relevance to anyone interested in ongoing debates about the nature and limits of philosophy, and the implications these debates have for our understanding of what role the intellectual might play in contemporary life. This book serves as both an excellent introduction to Rorty's work and an innovative critique which contributes to ongoing debates in the field. (shrink)

Robert Kane’s libertarian theory is often attacked on the grounds that undetermined self-forming actions are not amenable to contrastive explanation. I propose that we should understand contrastive explanations in terms of an appeal to structuring causes. Doing so reveals that Kane’s claim that there can be no contrastive explanation for self-forming actions is not an unwanted implication of his appeal to indeterminism, but is actually an implication of the fact that the agent’s will is not yet appropriately structured. I then (...) explain how this can assist Kane with the luck objection. (shrink)

Let mathematical justification be the kind of justification obtained when a mathematician provides a proof of a theorem. Are Gettier cases possible for this kind of justification? At first sight we might think not: The standard for mathematical justification is proof and, since proof is bound at the hip with truth, there is no possibility of having an epistemically lucky justification of a true mathematical proposition. In this paper, I argue that Gettier cases are possible (and indeed actual) in mathematical (...) reasoning. By analysing these cases, I suggest that the Gettier phenomenon indicates some upshots for actual mathematical practice. (shrink)

Nietzsche and Hume agree that desire drives all human action and practical reasoning. This shared view helps them appreciate continuities between human and animal motivation and sets them against a long tradition of rationalist rivals including Kant and Plato. In responding to Kant, Nietzsche further developed the Humean views that Kant himself was responding to. Kantians like Christine Korsgaard argue that reflective endorsement and rejection of options presented by desire demonstrates reason’s ability to independently drive reasoning and action. In Daybreak (...) 109, Nietzsche provides a simpler Humean explanation: reflective endorsement and rejection involve reflecting on one desire from the viewpoint of another, with desire as the only motivational force. This explains the attentional and hedonic phenomenology of reflective endorsement without ascribing any motivational force to rational processes independent of desire. (shrink)

The Cognitive Reflection Test is a widely used measure of the degree to which individuals override an intuitive response and engage in reflection. For both theoretical and practical reasons, it is widely taken to assess an important component of rational thought. In this paper, I will argue that while doing well on the CRT requires valuable cognitive capacities and dispositions, doing badly does not always indicate a lack of such capacities and dispositions. The CRT, I argue, offers respondents implicit (but (...) misleading) testimony: some of those who do badly do so due to a stronger disposition to defer to testimony. Since deference is not irrational, those who do badly need not be irrational, not even in part. (shrink)

RÉSUMÉ: Jaegwon Kim a montré de façon convaincante que les versions habituelles de la survenance décrivent en fait de simples relations de covariance et laissent échapper l’idée de dépendance. Mais puisque la dépendance du mental à l’endroit du physique est requise même par la version la plus faible du physicalisme, il semblerait bien que les notions actuelles de survenance n’accomplissent pas ce qu’on attendait d’elles. Je soutiens qu’en concevant la survenance dans une optique davidsonienne, comme une relation entre prédicats plutôt (...) qu’entre propriétés, on évite les inconvénients des versions plus familières, et que l’on donne prise, de la sorte, à un usage physicaliste de la survenance. (shrink)

Parents play a critical role in their child’s personal development and day-to-day experiences. However, as digital technologies are increasingly embedded in most New Zealand children’s everyday life activities parents face the task of ensuring their child’s online safety. To do so, they need to understand the way their child engages with and through these tools and make sense of the rapidly changing, and more technically complex, nature of digital devices. This presents a digital parenting dilemma: maximising children’s online opportunities while (...) minimising online risks and potential harm. This factsheet presents evidence about digital parenting in New Zealand based on nationally representative data collected from parents, caregivers and whānau and their children aged 9-17. It uses measures from the Global Kids Online project to explore the prevalence of different practices used by New Zealand parents to influence or mediate children’s internet use. (shrink)

Pietro Gori dedicates Nietzsche’s Pragmatism “To the wanderers and Good Europeans,” and Anglophone wanderers into Sarah de Sanctis’s translation will indeed find good European Nietzsche scholarship. The table of contents is a helpful map of the book, with five chapters consisting of twenty-eight sections on a sequence of philosophical and interpretive topics. Perspectival thought, addressed in the subtitle, is the explicit topic of the third chapter. Pragmatism, mentioned in the title, is the explicit topic of the fifth and final chapter. (...) While both topics also are discussed in many other places, the overall focus is on Nietzsche’s views of epistemology and truth.The first chapter discusses Nietzsche’s views of... (shrink)

Chance inevitably plays a role in law but it is not often that we consciously try to import an element of randomness into a legal process. Random Justice: On Lotteries and Legal Decision-Making explores the potential for the use of lotteries in social, and particularly legal, decision-making contexts. Utilizing a variety of disciplines and materials, Neil Duxbury considers in detail the history, advantages, and drawbacks of deciding issues of social significance by lot and argues that the value of the (...) lottery as a legal decision-making device has generally been underestimated. The very fact that there exists widespread resistance to the use of lotteries for legal decision-making purposes betrays a commonly held belief that legal processes are generally more important than are legal outcomes. Where, owing to the existence of indeterminacy, the process of reasoning is likely to be excessively protracted and the reasons provided strongly contestable, the most cost-efficient and impartial decision-making strategy may well be recourse to lot. Aversion to this strategy, while generally understandable, is not necessarily rational. Yet in law, as Professor Duxbury demonstrates, reason is generally valued more highly than is rationality. The lottery is often conceived to be a decision-making device that operates in isolation. Yet lotteries can frequently and profitably be incorporated into other decision-frameworks. The book concludes by controversially considering how lotteries might be so incorporated and also advances the thesis that it may sometimes be sensible to require that adjudication takes place in the shadow of a lottery. (shrink)

Structural realists contend that the properties and relations in the world are more fundamental than the individuals. However, the standard model theory used to analyse the structure of logical theories can make it difficult to see how such an idea could be coherent or workable: for in that theory, properties and relations are constructed as sets of individuals. In this paper, I look at three ways in which structuralists might hope for an alternative: by appealing to predicate-functor logic, Tractarian geometry, (...) or cylindric algebras. I argue that the first two are problematic, but that the third is promising. (shrink)

Introduction. Bert HAMMINGA and Neil DE MARCHI: Préface. Bert HAMMINGA and Neil DE MARCHI: Idealization and the Defence of Economics: Notes Toward a History. Part I: General Observations on Idealization in Economics. Kevin D. HOOVER: Six Queries about Idealization in an Empirical Context. Bernard WALLISER: Three Generalization Processes for Economic Models. Steven COOK and David HENDRY: The Theory of Reduction in Econometrics. Maarten C.W. JANSSEN: Economic Models and Their Applications. Adolfo GARCÍA DE LA SIENRA: Idealization and Empirical Adequacy (...) in Economic Theory. Izabella NOWAKOWA and Leszek NOWAK: On Correspondence between Economic Theories. Uskali MÄKI: Isolation, Idealization and Truth in Economics. Part II: Case Studies of Idealization in Economics. Nancy CARTWRIGHT: Mill and Menger: Ideal Elements and Stable Tendencies. Wolfgang BALZER: Exchange Versus Influence: A Case of Idealization. Kees COOLS, Bert HAMMINGA, Theo A.F. KUIPERS: Truth Approximation by Concretization in Capital Structure Theory. Daniel M. HAUSMAN: Paul Samuelson as Dr. Frankenstein: When an Idealization Runs Amuck. Hugo A. KEUZENKAMP: What if an Idealization is Problematic? The Case of the Homogeneity Condition in Consumer Demand. Werner DIEDERICH: Nowak on Explanation and Idealization in Marx's 'Capital'. Gérard JORLAND: Idealization and Transformation. Jack BIRNER: Idealizations and Theory Development in Economics. Some History and Logic of the Logic Discovery. Discussions. Leszek NOWAK: The Idealizational Methodology and Economics. Replies to Diederich, Hoover, Janssen, Jorland and Mäki. (shrink)

Which is worse: Doing evil or being evil? If we are free to define ourselves through our choices, as existentialism posits, then the latter is worse. This paper attempts to resolve the issue of the difference between religious (group) ethics and the ethics of a person of faith that embraces individuals with an existential understanding. In the existential view, the individual (whether the self or the other) is the primary concern, and so the issue of personal relational morality supersedes religious (...) narratives, social morality and popular ethics (White, 2002). If we think and choose, there is the possibility that we may occasionally make a mistake and do evil. However, if we do not think about our choices, and if the conventions we hold happen to be flawed in some way, then we become defined by a continual cycle of mistakes. Existentialism teaches that we become who we are in the process of making choices; therefore the difference between doing evil and being evil can be found in the small but important flow of thinking, relating and choosing. (shrink)

Zygon®, Volume 57, Issue 1, Page 25-45, March 2022.

The Ethics of Sex: An Introduction systematically and comprehensively examines the ethical issues surrounding the concept of sex. It addresses important questions such as: How to approach questions of sexual ethics in a philosophical way? Must we give affirmative consent to all sexual activity and what would be the impact of implementing an affirmative consent standard into law? Should we promote monogamy as the best way to live? Can the tools of behavioural economics offer insights into the issues of sexual (...) ethics? What constitutes harassment? How does the state involve itself in the private sexual lives of its citizens and is it justified in doing so? What privacy issues arise within relationships due to the development of technology? What ethical issues may arise as the result of future technological developments? Including discussion questions and suggestions for further reading at the end of each chapter The Ethics of Sex is the perfect philosophical introduction to the perennially topical issue, and ideal reading for students taking courses within the fields of applied ethics, sociology, law, religion and politics. (shrink)

This book is based upon a lecture series that took place between September 2013 and May 2014 to inaugurate the new Canadian Museum for Human Rights. It brings together some of the most influential contemporary thinkers on the theory and practice of human rights.

"16 'On Justification and Interpretation', ARSP-Beiheft, 53, pp. 255-68." -- "17 'Authority Reasons in Legal Interpretation and Moral Reasoning', ARSP Supplementa (III), pp. 144-52." -- "18 'Two Types of Substantive Reasons: The Core of a Theory of Common-Law Justification', Cornell Law Review, 63, pp. 707-88." -- "19 'Reasonableness and Objectivity', Notre Dame Law Review, 74, pp. 1575-603.

This collection of essays, published to coincide with Tony Honore's sixty-fifth birthday, focuses on the areas where Honore's thought has made the most significant contribution: Roman law and jurisprudence. Included are essays by P.S. Atiyah, Zenon Bankowski, John Bell, Peter Birks, John W. Cairs, Hugh Collins, David Daube, W. M. Gordon, J. W. Harris Nicola Lacey, A. D. E. Lewis, Detlef Liebs, G. D. MacCormack, Neil MacCormick, G. Maher, Pieter Norr, Alan Rodger, and Peter Stein.

Neil Cooper; V*—Moral Nihilism, Proceedings of the Aristotelian Society, Volume 74, Issue 1, 1 June 1974, Pages 75–90, https://doi.org/10.1093/aristotelian/74.1.