Over the last decade, our appreciation of the importance of the nucleolus for cellular function has progressed from the ordinary to the extraordinary. We no longer think of the nucleolus as simply the site of ribosome production, or a dynamic subnuclear body noted by pathologists for its changes in size and shape with malignancy. Instead, the nucleolus has emerged as a key controller of many cellular processes that are fundamental to normal cell homeostasis and the target for dysregulation in many (...) human diseases; in some cases, independent of its functions in ribosome biogenesis. These extra‐nucleolar or new functions, which we term “non‐canonical” to distinguish them from the more traditional role of the nucleolus in ribosome synthesis, are the focus of this review. In particular, we explore how these non‐canonical functions may provide novel insights into human disease and in some cases new targets for therapeutic development. (shrink)

Martin Heidegger regnes som den mest innflytelsesrike filosofen i det 20. århundre. Det er også kjent at han hadde nazistiske sympatier og var medlem av NSDAP i perioden 1933-1945. Utgivelsen av Svarte hefter (Schwarze Hefte) - hans filosofiske dagbøker skrevet i perioden fra 1931-1975 - gir et mer detaljert bilde av Heideggers nazisme. Vi får en tydelig dokumentasjon ikke bare av hans dyrking av Hitler og nasjonalsosialismen, men også av et verdenssyn preget av antisemittisme. I heftene kan vi lese flere (...) konspiratoriske passasjer om en ±metafysisk jødedom?, der jødene er representanter for en verdensomspennende instrumentell rasjonalitet som har banet vei for materialisme og kapitalisme.I lys av dette må vi revurdere vårt forhold til Heidegger som filosof og stille oss følgende spørsmål: Skal vi lese alt Heidegger skrev, i lys av hans tid som nazist? Eller er tenkningen av et slikt format at den uansett går fri fra Heideggers politiske engasjement?Denne antologien er et forsøk på å gå inn på disse spørsmålene. Foruten oversettelser av blant annet deler av Svarte hefter fra tysk til norsk, får vi perspektiver fra en rekke internasjonalt anerkjente Heidegger-forskere som analyserer Heideggers politiske engasjement, antisemittisme, sivilisasjonskritikk og religionskritikk. (shrink)

As a subject for philosophizing about education, there are few topics as rich and significant as the role of public schools in fostering respect for sexual and religious diversity. The liberal state, it is said, has a clear mission to teach students to respect the rights of others to lead fundamentally different ways of life, and to provide students with the tools needed to make similarly fundamental choices about their own lives. The liberal state must do this, however, without undue (...) or excessive infringement on the rights of children and parents who believe that some common ways of life are, writ large, morally objectionable. This symposium paper features three arguments, each formulated by a different student in education or a related field. The first argues that LGBTQ role models must be provided in schools (through school resources or in person). The second argues that teachers are being placed in a very difficult position when such provision causes controversy with the surrounding community. The third argues that parents must not be given unchecked power over their children’s exposure to LGBTQ role modeling. (shrink)

This book project intends to serve as a course adoption book unpacking theories of biopolitical life-making and death-making, with chapters dedicated to specific objects that ostensibly affirm life (and argue for life's inextricable links to capital), but that ultimately reify a politics of death and erasure. Specific objects, such as the pink Kommen Foundation-branded handgun, the 'super user' of health care resources, and fat cells allow the authors to discuss the political junctures at which determinations of healthy and unhealthy, life (...) and death, are made. (shrink)

A partir de l’étude de corpus de textes, manuelle et informatique, nous présentons une réflexion sur l’analyse de texte ou de discours à travers l’exemple de l’exposition didactique. Celle-ci peut s’envisager à différents grains. Nous posons la question de la taille du texte, de son style collectif à travers sa disposition et ses marques. Nous interrogeons la pertinence du modèle choisi en relation avec la notion d’échelle. Enfin, nous posons la question de la résolution adéquate pour des logiciels d’analyse, à (...) l’aide d’une dizaine d’exemples. (shrink)

Zusammenfassung Der Beitrag stellt eine differenzierungstheoretische Perspektive auf Sportbeteiligung und Sportinteresse der Erwachsenenbevölkerung vor. Zugrunde liegen empirische Daten aus einer eigenen repräsentativen Bevölkerungsumfrage in Deutschland vom Herbst 2003, in der die Inklusion der Erwachsenen in sämtliche gesellschaftlichen Teilsysteme ermittelt wurde. Die Inklusion in den Sport wird mit Bezug auf die sekundäre Leistungsrolle des Breitensportlers und die Publikumsrolle des Sportzuschauers betrachtet; sodann wird möglichen Zusammenhängen zwischen der Ausprägung der Inklusion in den Sport mit ungleichheitstheoretisch geläufigen Merkmalen sozialer Lage, darüber hinaus dann (...) auch mit der Ausprägung anderer Inklusionsverhältnisse nachgegangen. (shrink)

The artistic work of photographer Gudio Baselgia focuses on landscapes formed by nature s forces and, more recently, on the sky with the stellar and solar movements and phenomena as we see them from earth. Celestial mechanics have fascinated mankind in all known cultures, the Babylonians and ancient Egyptians as well as the Greek and Celts, the Maya, or the ancient Indians and Chinese. Until the present day we look at the sky and keep being amazed, and try to read (...) what it tells us. Many artists throughout history have been captivated by the spectacle we observe above us day and night. The modern term astrodynamics describes all movements of celestial bodies, in particular the solar system including the moon and other satellites, asteroids and comets, but also movements of stars within a stellar system or galaxy, or of galaxies towards each other. They are well understood today and depicted in coordinate systems and elaborate visualizations. Guido Baselgia s artistic project on astrodynamics and celestial phenomena has no scientific or didactic ambition. His analogue camera is used as a recorder inscribing the movement of stars on the light-sensitive surface of photographic paper. Thus Baselgia s images make traceable the trajectory of celestial bodies invisible to the human eye and show us astounding occurrences of light and shadow. Baselgia has been captivated in particular also by the phenomenon of the umbra, planet earth s shadow thrown into space. It becomes visible occasionally on a clear evening at sunset when a slight mist lies at the horizon: looking in opposite direction to the sun, a dark and sharply marked band of shadow can be seen rising while sun sets behind the observer. But also by recording sunrise and sunset at the polar circle or the tropic, Baselgia visualizes the geometry of celestial mechanics and the concurrence of forces, as well as the miracle of light as such that leaves us awestruck today as much as it did our ancestors. The new book "Guido Baselgia Light Fall" presents 80 outstanding black-and-white images from the artist s Light Fall project taken in Norway, the Tierra del Fuego archipelago in Argentina, in Ecuador, and the Swiss Alps. The brilliant tritone plates are complemented with essays by the German scholar Andrea Gnam and Swiss photography critic Nadine Olonetzky. ". (shrink)

Name der Zeitschrift: Klio Jahrgang: 97 Heft: 1 Seiten: 383-386.

ArgumentTextual and material evidence suggests that early Byzantine architects, known asmechanikoi, were comprehensively educated in the mathematical sciences according to contemporary standards. This paper explores the significance of the astronomical and optical sciences for the working methods of the twomechanikoiof Hagia Sophia in Constantinople, Anthemios of Tralles and Isidoros of Miletus. It argues that one major concern in the sixth-century architectural design of the Great Church was the visual effect of its sacred interior, particularly the luminosity within. Anthemios and Isidoros (...) seem to have been thoroughly conversant with the ancient corpus of astronomical and optical writings and, as will be shown, implemented their theoretical knowledge in the design of Hagia Sophia. Specifically, the paper demonstrates that the orientation of the building's longitudinal axis coincides with the sunrise on the winter solstice according to ancient computations, implying that the orientation was intentionally calculated in order to secure an advantageous natural illumination of the interior. Light and visual effects served to reinforce the symbolic significance of the sacred space that furthermore provides evidence for optical considerations with respect to late antique concepts of light and vision. (shrink)

This article re-examines the profession of the late antique mechanikos, who is identified as a practising architect with a sound liberal arts education as well as practical training. Despite the practical orientation of his profession, the mechanikos was of high social standing. This was possible because the practical utility of a vocation was increasingly acknowledged favourably in late antiquity and is reflected in early Byzantine portrayals of patrons, who allegedly invested hard labour in prestigious building campaigns and posed as the (...) supreme architects. (shrink)

Warning research participants and patients about potential risks associated with participation/treatment is a fundamental part of consent. However, such risk warnings might cause negative expectations and subsequent nocebo effects (i.e., negative expectations cause negative outcomes) in participants. Because no existing review documents how past research has quantitatively examined nocebo effects – and negative expectations – arising from consent risk warnings, we conducted a pre-registered scoping review (N = 9). We identified several methodological issues across these studies, which in addition to (...) mixed findings, limit conclusions about whether risk warnings cause nocebo effects. (shrink)

Values and virtues play an important role in military organizations. In particular, armies can be understood as institutions that are guided by values and virtues, endeavoring to promote them. A common understanding within the military organization relating the relevant values and virtues is therefore essential. In many armed forces, there are lists of relevant values and virtues that have mostly grown historically. In the context of this volume, special emphasis has been devoted to the value and virtue culture and its (...) importance within a military organization. Specifically, the dimensional structure of values and virtues was analyzed. Through a systematic survey of the military target groups and a factor analytical assessment within the Swiss Armed Forces, the core values and virtues were categorized and defined. These values and virtues describe the current culture of the Swiss Armed Forces and contribute to a more binding support of the objectives of military education. (shrink)

How do the practices of philosophy and film converge in ethical and political theory? Untimely Affects is an ethical and aesthetic interweaving of Deleuzian philosophy and close film analysis to discern how thought persists productively after the horrors of World War II. In the first extensive analysis of Chris Marker and Alain Resnais' films, Nadine Boljkovac draws on concepts and images that interrogate 'what we are now living through', in the words of Klossowski's Nietzsche. Mindful of the seen and (...) unseen 'that quicken the heart', this book of film-philosophy discerns new and deeply ethical life-affirming possibilities through its weave of cine-philosophy. As such, this book speaks directly to essences of cinema, thought and life through creative untimeliness and the idea of the 'ever new'. (shrink)

In January 2022 the new Dutch Civic Integration programme was launched together with promises of improvements it would bring in facilitating the ‘integration’ of newcomers to the Netherlands. This study presents a critical discourse analysis of texts intended for municipalities to take on their new coordinating role in this programme. The analysis aims to understand the discourse in the texts, which actors are mobilized by them, and the role these texts and these actors play in processes of governmental racialization. The (...) analysis demonstrates shifting complex assemblages are brought into cascades of governance in which all actors are disciplined to accept the problem of integration as a problem of cultural difference and distance, and then furthermore disciplined to adopt new practices deemed necessary to identify and even ‘objectively’ measure the inherent traits contributing to this problematic. Lastly, the analysis displays that all actors are disciplined to accept the solution of ‘spontaneous compliance’; a series of practices and knowledges, which move the civic integration programme beyond an aim of responsibilization, into a programme of internalization, wherein newcomers are expected to own and address their problematic ‘nature’, making ‘modern’ values their own. (shrink)

Pregnancy is thought to be a metabolically very expensive endeavor, yet investigations have produced inconsistent results concerning the responsiveness of human birth weight to maternal nutritional stress or nutritional intervention. These findings have led some researchers to conclude that fetal growth is strongly buffered against fluctuations in maternal energy balance, making the fetus in effect a “nearly perfect parasite.” This buffering would appear to be a reasonable adaptive response given the high risk of morbidity and mortality associated with low birth (...) weight. However, a life-history approach leads to the prediction that maternal investment strategies in pregnancy should be geared toward maximizing lifetime reproductive success rather than simply the success of the current pregnancy, and by extension that maternal investment strategies should vary with reproductive value. The physiology of human pregnancy in fact appears to include a number of mechanisms that protect maternal energy resources from diversion to the fetus and preserve them for future reproductive events. These mechanisms include adjustment of blood flow to the uterus and perhaps minor adjustments in gestation length, although evidence for the latter is scant. Suggestions are made for ways of investigating these maternal options. (shrink)

For more than twenty years, Swiss photographer Tobias Madörin has been working on his photo series Topos. Creating staged tableaux in the manner of nineteenth-century painters, Madörin investigates the interaction between the inhabitants and their surrounding environments in countries as diverse as Spain, Uganda, Indonesia, and Japan. His large-scale images examine communal spaces, the outskirts of metropolises, waste disposals sites, and landscapes marked by agriculture and mining. Madörin's work reveals that these locations are the products of human visions and ideals, (...) yet they are also places of environmental exploitation. This tension, as well as Madörin's intelligent and empathetic approach to his subjects, makes his photographs evocative and complex. This book includes lavish, full-page photographs, many of which have never been published, and an introductory essay by Nadine Olonetzky that explains and contextualizes the photographer's oeuvre. (shrink)

This article explores Professor T.F.J. Dreyer's definition for preaching that he developed for preaching in the Netherdutch Reformed Church of Africa (NRCA) three decades ago. Dreyer's own homiletical perspective towards preaching developed continuously through numerous philosophical paradigm shifts since 1989. His basis theory plays an important role in the theological training of the church's students today. The aim of the research is to reflect on the changes, following Dreyer's homiletical development over three decades. The research discovers a strong prophetical character (...) in the homiletical approach of Dreyer and concludes by asking how a kairos moment of prophetical speech can benefit the NRCA. CONTRIBUTION: This research hopes to contribute to the existing research that was done in the homiletical field of traditional Afrikaans-speaking churches in South Africa. The research also contributes by identifying some homiletical perspectives that can help the church to proclaim the gospel in times of transition. (shrink)

It is widely accepted that Russell wrongly took Wittgenstein to be concerned with the conditions required for an ideal language in his _Tractatus Logico-Philosophicus_. Given Russell’s relatively extensive communications with Wittgenstein, this misunderstanding is puzzling. I argue that Russell’s mistake rests on two prior assumptions for which he had some justification. First, communications with Wittgenstein were plausibly interpreted by Russell as confirming, rather than refuting, the belief that Wittgenstein shared with him the view that psychology, epistemology, and logic are interdependent. (...) Second, results from these areas in turn led Russell to the view that ordinary language is irredeemably vague and, as such, in need of replacement with an ideal language. In truth, however, Wittgenstein severed psychology and epistemology from his work and saw vagueness as a surface phenomenon only. (shrink)

Trois lois ont, entre 1993 et 2002, codifié le dispositif français dit de « l’accouchement sous X », qui autorise une femme à accoucher gratuitement dans une maternité sans révéler son identité. La première a durci ce dispositif en l’insérant dans le code civil, la seconde a tenté de l’assouplir et la dernière a créé un organisme chargé de faciliter, pour les personnes nées « sous X », l’accès à la connaissance de leurs origines. Dans les débats parlementaires qui ont (...) précédé l’adoption de ces lois, l’histoire a largement été utilisée comme argument, mais on est passé de l’histoire nationale à l’histoire personnelle, et de la « tradition française » justifiant le maintien du secret de l’accouchement, au droit à la vérité de la biographie légitimant la possibilité de la réversibilité du secret. (shrink)

Cet important ouvrage de l’historienne Sasha Turner porte sur la période de 1780 à 1834 à la Jamaïque, période pendant laquelle la perspective de l’abolition de la traite (qui interviendra en 1807), puis de l’esclavage lui-même, conduisit, là comme ailleurs, les différents acteurs du système esclavagiste à réviser la politique jusqu’alors menée en matière de reproduction de la main d’œuvre et à adopter, bon gré mal gré, une politique nataliste. La connaissance des conditions de vie des femmes...

La philosophie de Baudrillard est inédite puisqu'il possède une façon originale de voir le monde, ses yeux étant ceux d'un philosophe-critique, d'un sociologue, d'un journaliste et d'un pataphysicien. Ce faisant, il possède une manière fort intéressante de nommer les faits. D'où toute la série de termes qu'il revisite ou invente surtout ceux formés par le préfixe hyper comme hyperconsommation, hypermarché, hyperréel, hypercorps, hyperespace et bien d'autres. Malgré sa quête du sens et du réel, Baudrillard débouche sur le non-sens et proclame (...) moyennement l'absence du réel. C'est comme si tout l'objectif de sa quête était uniquement la description du réel disparu et non la recherche et l'instauration du réel voire d'un nouveau réel. La recherche conduite ici s'attaque à la pensée hyperréelle de Jean Baudrillard tout en présentant l'originalité de cette pensée singulière et controversée. (shrink)

Der Philanthrop Joachim Heinrich Campe publizierte gegen Ende des 18. Jahrhunderts zwei Ratgeber für bürgerliche Mädchen und Jungen. Damit wollte er sie besser auf ihre zukünftigen geschlechtsspezifischen Pflichten vorbereiten. Sein Mädchenratgeber Väterlicher Rath für meine Tochter erhält in der modernen Geschlechterforschung.

A recurrent theme of human–machine interaction is how interaction is defined and what kind of information is relevant for successful communication. In accordance with the theoretical strategies of social cognition and technical philosophy, we propose a pragmatic interactive approach, to understand the concept of information in human–machine interaction. We start with the investigation of interpersonal interaction and human–machine interaction by concerning triangulation as guiding principle. To illustrate human–machine interaction, we will mainly focus on the interactive relationship between human cognitive skills (...) and their technological environments. In triadic interaction, the concept of information cannot only be understood as a syntactic transformation as in the dyadic relationship. We argue that information as pragmatic action patterns can be understood as physically embodied units that is not purely formal but generated in interactive processes and stabilized in use. By exploring how the concept of affordance is applied in psychology, anthropology and human-centered design, we provide a notion of pragmatic information, focusing on users in the development and use of machines or software systems. The triadic interaction of end user, development team, and product leads to a successful human–machine interaction. This theoretical framework enables us to understand how the new socio-technological environments expand our scope of action and how we form, interpret, and learn to deal with patterns of action among ourselves and with machines. (shrink)

Chan Buddhist discourse refers repeatedly to many kinds of animals, particularly dogs and cats, as symbols or in fables in order to comment ironically on human attitudes and behavior. These creatures are appreciated for their positive qualities yet are also scathingly criticized for representing a lack of discipline and self-control. This paper considers how a couple of Chan gongan cases featuring animals are related to the Mahayana doctrine of universal Buddha-nature. Does Chan accept and approve or reject and refute the (...) orthodox view, does it craft a standpoint of ironic inconclusiveness that deliberately bypasses and reorients traditional doctrinal disputes, or do these cases primarily express an allegorical message regarding possibilities or challenges for humans seeking to attain an experience of enlightenment? (shrink)

Increasingly, professionalism has been recognized as a core competency for health service professionals and is the domain in which vexing competence problems are observed in trainees. We begin by describing manifestations of problems of professionalism in accord with the values that fall within the rubric of this multifaceted construct. We provide an approach for evaluating problems of professionalism and discuss intervention for trainees with mild, moderate, or severe problems in this domain. We propose implications for training focused on enhancing the (...) culture of programs; bolstering the education, guidance, and mentoring provided related to professionalism; and encouraging best practices for addressing trainees with problems of professionalism. We conclude by sharing ideas about defining professionalism, identifying problems of professionalism, strengthening our approach to assessing professionalism and intervening when problems are evident, developing strategies for preventing professionalism problems, and ensuring that psychologists take seriously their responsibility to address professionalism concerns with colleagues. (shrink)